-- dump date 20111121_010416 -- class Genbank::misc_feature -- table misc_feature_note -- id note 637380000001 Nuclease-related domain; Region: NERD; pfam08378 637380000002 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 637380000003 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 637380000004 putative active site [active] 637380000005 putative NTP binding site [chemical binding]; other site 637380000006 putative nucleic acid binding site [nucleotide binding]; other site 637380000007 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 637380000008 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 637380000009 active site 637380000010 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 637380000011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380000012 S-adenosylmethionine binding site [chemical binding]; other site 637380000013 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 637380000014 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 637380000015 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 637380000016 Int/Topo IB signature motif; other site 637380000017 active site 637380000018 DNA binding site [nucleotide binding] 637380000019 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 637380000020 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 637380000021 Ligand Binding Site [chemical binding]; other site 637380000022 HEPN domain; Region: HEPN; cl00824 637380000023 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 637380000024 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 637380000025 putative active site [active] 637380000026 putative NTP binding site [chemical binding]; other site 637380000027 putative nucleic acid binding site [nucleotide binding]; other site 637380000028 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 637380000029 active site 637380000030 NTP binding site [chemical binding]; other site 637380000031 metal binding triad [ion binding]; metal-binding site 637380000032 antibiotic binding site [chemical binding]; other site 637380000033 Divergent AAA domain; Region: AAA_4; pfam04326 637380000034 30S ribosomal protein S1; Provisional; Region: rpsA; PRK13806 637380000035 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 637380000036 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 637380000037 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380000038 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380000039 potential frameshift: common BLAST hit: gi|227811475|ref|YP_002811486.1| IS231-related, transposase 637380000040 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637380000041 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637380000042 Abi-like protein; Region: Abi_2; cl01988 637380000043 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 637380000044 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380000045 Coenzyme A binding pocket [chemical binding]; other site 637380000046 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637380000047 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637380000048 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637380000049 Transposase [DNA replication, recombination, and repair]; Region: COG5421 637380000050 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380000051 non-specific DNA binding site [nucleotide binding]; other site 637380000052 salt bridge; other site 637380000053 sequence-specific DNA binding site [nucleotide binding]; other site 637380000054 Domain of unknown function (DUF373); Region: DUF373; cl12079 637380000055 AAA-like domain; Region: AAA_10; pfam12846 637380000056 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380000057 Walker B motif; other site 637380000058 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 637380000059 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 637380000060 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 637380000061 DNA binding residues [nucleotide binding] 637380000062 S-layer homology domain; Region: SLH; pfam00395 637380000063 S-layer homology domain; Region: SLH; pfam00395 637380000064 S-layer homology domain; Region: SLH; pfam00395 637380000065 SAF domain; Region: SAF; cl00555 637380000066 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 637380000067 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 637380000068 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 637380000069 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380000070 Walker A motif; other site 637380000071 ATP binding site [chemical binding]; other site 637380000072 Walker B motif; other site 637380000073 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 637380000074 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 637380000075 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 637380000076 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 637380000077 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 637380000078 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380000079 AAA-like domain; Region: AAA_10; pfam12846 637380000080 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 637380000081 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 637380000082 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637380000083 catalytic residue [active] 637380000084 Peptidase family M23; Region: Peptidase_M23; pfam01551 637380000085 NlpC/P60 family; Region: NLPC_P60; cl11438 637380000086 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 637380000087 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 637380000088 Predicted membrane protein [Function unknown]; Region: COG2311 637380000089 Protein of unknown function (DUF418); Region: DUF418; cl12135 637380000090 Protein of unknown function (DUF418); Region: DUF418; cl12135 637380000091 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 637380000092 catalytic residues [active] 637380000093 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 637380000094 heme-binding site [chemical binding]; other site 637380000095 S-layer homology domain; Region: SLH; pfam00395 637380000096 S-layer homology domain; Region: SLH; pfam00395 637380000097 S-layer homology domain; Region: SLH; pfam00395 637380000098 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 637380000099 Acetokinase family; Region: Acetate_kinase; cl01029 637380000100 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 637380000101 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 637380000102 active site 637380000103 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 637380000104 active site 637380000105 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 637380000106 active site 637380000107 tetramer interface [polypeptide binding]; other site 637380000108 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 637380000109 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 637380000110 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 637380000111 putative transposase OrfB; Reviewed; Region: PHA02517 637380000112 Integrase core domain; Region: rve; cl01316 637380000113 putative transposase OrfB; Reviewed; Region: PHA02517 637380000114 putative transposase OrfB; Reviewed; Region: PHA02517 637380000115 Anthrax toxin lethal factor, N- and C-terminal domain; Region: ATLF; pfam07737 637380000116 Anthrax toxin LF subunit; Region: Anthrax_toxA; pfam03497 637380000117 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 637380000118 Transposase domain (DUF772); Region: DUF772; cl12084 637380000119 Domain of unknown function (DUF205); Region: DUF205; cl00410 637380000120 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380000121 PRD domain; Region: PRD; pfam00874 637380000122 PRD domain; Region: PRD; pfam00874 637380000123 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 637380000124 Histidine kinase N terminal; Region: HisK_N; pfam09385 637380000125 potential frameshift: common BLAST hit: gi|21392830|ref|NP_652910.1| transposase X 637380000126 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 637380000127 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 637380000128 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 637380000129 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 637380000130 catalytic residues [active] 637380000131 catalytic nucleophile [active] 637380000132 Presynaptic Site I dimer interface [polypeptide binding]; other site 637380000133 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 637380000134 Synaptic Flat tetramer interface [polypeptide binding]; other site 637380000135 Synaptic Site I dimer interface [polypeptide binding]; other site 637380000136 DNA binding site [nucleotide binding] 637380000137 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380000138 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 637380000139 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 637380000140 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 637380000141 PA14 domain; Region: PA14; cl08459 637380000142 Clostridial binary toxin B/anthrax toxin PA; Region: Binary_toxB; pfam03495 637380000143 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637380000144 dimerization interface [polypeptide binding]; other site 637380000145 putative DNA binding site [nucleotide binding]; other site 637380000146 putative Zn2+ binding site [ion binding]; other site 637380000147 Anthrax toxin lethal factor, N- and C-terminal domain; Region: ATLF; pfam07737 637380000148 Anthrax toxin lethal factor, middle domain; Region: Anthrax-tox_M; pfam09156 637380000149 Anthrax toxin lethal factor, N- and C-terminal domain; Region: ATLF; pfam07737 637380000150 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 637380000151 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 637380000152 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 637380000153 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 637380000154 Phage integrase family; Region: Phage_integrase; pfam00589 637380000155 Int/Topo IB signature motif; other site 637380000156 active site 637380000157 DNA binding site [nucleotide binding] 637380000158 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 637380000159 Proteins of 100 residues with WXG; Region: WXG100; cl02005 637380000160 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 637380000161 putative transposase OrfB; Reviewed; Region: PHA02517 637380000162 Integrase core domain; Region: rve; cl01316 637380000163 putative transposase OrfB; Reviewed; Region: PHA02517 637380000164 Integrase core domain; Region: rve; cl01316 637380000165 putative transposase OrfB; Reviewed; Region: PHA02517 637380000166 YodA lipocalin-like domain; Region: YodA; cl01365 637380000167 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 637380000168 synthetase active site [active] 637380000169 NTP binding site [chemical binding]; other site 637380000170 metal binding site [ion binding]; metal-binding site 637380000171 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 637380000172 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 637380000173 DNA binding site [nucleotide binding] 637380000174 Int/Topo IB signature motif; other site 637380000175 active site 637380000176 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380000177 Walker A motif; other site 637380000178 ATP binding site [chemical binding]; other site 637380000179 Walker B motif; other site 637380000180 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 637380000181 Sm1 motif; other site 637380000182 D3 - B interaction site; other site 637380000183 D1 - D2 interaction site; other site 637380000184 Hfq - Hfq interaction site; other site 637380000185 RNA binding pocket [nucleotide binding]; other site 637380000186 Sm2 motif; other site 637380000187 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637380000188 dimerization interface [polypeptide binding]; other site 637380000189 putative DNA binding site [nucleotide binding]; other site 637380000190 putative Zn2+ binding site [ion binding]; other site 637380000191 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 637380000192 Staphylococcal nuclease homologues; Region: SNc; smart00318 637380000193 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 637380000194 Catalytic site; other site 637380000195 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362 637380000196 DNA topoisomerase III; Provisional; Region: PRK07726 637380000197 active site 637380000198 putative metal-binding site [ion binding]; other site 637380000199 putative interdomain interaction site [polypeptide binding]; other site 637380000200 putative nucleotide binding site [chemical binding]; other site 637380000201 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 637380000202 domain I; other site 637380000203 DNA binding groove [nucleotide binding] 637380000204 phosphate binding site [ion binding]; other site 637380000205 domain II; other site 637380000206 domain III; other site 637380000207 nucleotide binding site [chemical binding]; other site 637380000208 catalytic site [active] 637380000209 domain IV; other site 637380000210 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 637380000211 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 637380000212 DNA topoisomerase III; Validated; Region: PRK08173 637380000213 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 637380000214 NlpC/P60 family; Region: NLPC_P60; cl11438 637380000215 AAA-like domain; Region: AAA_10; pfam12846 637380000216 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 637380000217 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl14888 637380000218 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380000219 Walker A motif; other site 637380000220 ATP binding site [chemical binding]; other site 637380000221 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl14888 637380000222 TrbC/VIRB2 family; Region: TrbC; cl01583 637380000223 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 637380000224 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380000225 Walker A motif; other site 637380000226 ATP binding site [chemical binding]; other site 637380000227 Walker B motif; other site 637380000228 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 637380000229 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 637380000230 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 637380000231 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 637380000232 P-loop; other site 637380000233 Magnesium ion binding site [ion binding]; other site 637380000234 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 637380000235 Magnesium ion binding site [ion binding]; other site 637380000236 S-layer homology domain; Region: SLH; pfam00395 637380000237 S-layer homology domain; Region: SLH; pfam00395 637380000238 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 637380000239 active site 637380000240 metal binding site [ion binding]; metal-binding site 637380000241 Integrase core domain; Region: rve; cl01316 637380000242 putative transposase OrfB; Reviewed; Region: PHA02517 637380000243 Domain of unknown function (DUF74); Region: DUF74; cl00426 637380000244 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 637380000245 Protein of unknown function (DUF523); Region: DUF523; cl00733 637380000246 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380000247 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380000248 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637380000249 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637380000250 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 637380000251 active site 637380000252 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 637380000253 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 637380000254 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380000255 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 637380000256 P-loop; other site 637380000257 active site 637380000258 phosphorylation site [posttranslational modification] 637380000259 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 637380000260 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 637380000261 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 637380000262 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 637380000263 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 637380000264 putative active site [active] 637380000265 putative metal binding site [ion binding]; other site 637380000266 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 637380000267 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 637380000268 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637380000269 dimerization interface [polypeptide binding]; other site 637380000270 putative DNA binding site [nucleotide binding]; other site 637380000271 putative Zn2+ binding site [ion binding]; other site 637380000272 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637380000273 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 637380000274 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637380000275 Catalytic site [active] 637380000276 Histidine kinase N terminal; Region: HisK_N; pfam09385 637380000277 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 637380000278 PRD domain; Region: PRD; pfam00874 637380000279 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 637380000280 LysE type translocator; Region: LysE; cl00565 637380000281 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 637380000282 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 637380000283 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380000284 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 637380000285 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 637380000286 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637380000287 peptide binding site [polypeptide binding]; other site 637380000288 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 637380000289 DNA polymerase IV; Reviewed; Region: PRK03103 637380000290 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 637380000291 active site 637380000292 DNA binding site [nucleotide binding] 637380000293 YolD-like protein; Region: YolD; pfam08863 637380000294 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 637380000295 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 637380000296 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 637380000297 DNA binding site [nucleotide binding] 637380000298 active site 637380000299 Int/Topo IB signature motif; other site 637380000300 catalytic residues [active] 637380000301 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 637380000302 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362 637380000303 DNA topoisomerase III; Provisional; Region: PRK07726 637380000304 active site 637380000305 putative interdomain interaction site [polypeptide binding]; other site 637380000306 putative metal-binding site [ion binding]; other site 637380000307 putative nucleotide binding site [chemical binding]; other site 637380000308 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 637380000309 domain I; other site 637380000310 DNA binding groove [nucleotide binding] 637380000311 phosphate binding site [ion binding]; other site 637380000312 domain II; other site 637380000313 domain III; other site 637380000314 nucleotide binding site [chemical binding]; other site 637380000315 catalytic site [active] 637380000316 domain IV; other site 637380000317 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 637380000318 DNA primase, catalytic core; Region: dnaG; TIGR01391 637380000319 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 637380000320 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 637380000321 DNA binding residues [nucleotide binding] 637380000322 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 637380000323 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 637380000324 Phage-related protein [Function unknown]; Region: COG5412 637380000325 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 637380000326 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 637380000327 catalytic residues [active] 637380000328 catalytic nucleophile [active] 637380000329 Presynaptic Site I dimer interface [polypeptide binding]; other site 637380000330 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 637380000331 Synaptic Flat tetramer interface [polypeptide binding]; other site 637380000332 Synaptic Site I dimer interface [polypeptide binding]; other site 637380000333 DNA binding site [nucleotide binding] 637380000334 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637380000335 DNA-binding interface [nucleotide binding]; DNA binding site 637380000336 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 637380000337 hypothetical protein; Validated; Region: PRK06672 637380000338 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380000339 Walker A motif; other site 637380000340 ATP binding site [chemical binding]; other site 637380000341 Walker B motif; other site 637380000342 arginine finger; other site 637380000343 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 637380000344 DnaA box-binding interface [nucleotide binding]; other site 637380000345 DNA polymerase III subunit beta; Validated; Region: PRK05643 637380000346 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 637380000347 putative DNA binding surface [nucleotide binding]; other site 637380000348 dimer interface [polypeptide binding]; other site 637380000349 beta-clamp/clamp loader binding surface; other site 637380000350 beta-clamp/translesion DNA polymerase binding surface; other site 637380000351 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 637380000352 recombination protein F; Reviewed; Region: recF; PRK00064 637380000353 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 637380000354 Walker A/P-loop; other site 637380000355 ATP binding site [chemical binding]; other site 637380000356 Q-loop/lid; other site 637380000357 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380000358 ABC transporter signature motif; other site 637380000359 Walker B; other site 637380000360 D-loop; other site 637380000361 H-loop/switch region; other site 637380000362 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 637380000363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380000364 Mg2+ binding site [ion binding]; other site 637380000365 G-X-G motif; other site 637380000366 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 637380000367 anchoring element; other site 637380000368 dimer interface [polypeptide binding]; other site 637380000369 ATP binding site [chemical binding]; other site 637380000370 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 637380000371 active site 637380000372 putative metal-binding site [ion binding]; other site 637380000373 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 637380000374 DNA gyrase subunit A; Validated; Region: PRK05560 637380000375 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 637380000376 CAP-like domain; other site 637380000377 Active site [active] 637380000378 primary dimer interface [polypeptide binding]; other site 637380000379 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637380000380 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637380000381 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637380000382 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637380000383 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637380000384 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637380000385 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 637380000386 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 637380000387 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 637380000388 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 637380000389 active site 637380000390 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 637380000391 Beta-lactamase; Region: Beta-lactamase; cl01009 637380000392 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 637380000393 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 637380000394 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 637380000395 active site 637380000396 multimer interface [polypeptide binding]; other site 637380000397 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 637380000398 predicted active site [active] 637380000399 catalytic triad [active] 637380000400 seryl-tRNA synthetase; Provisional; Region: PRK05431 637380000401 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 637380000402 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 637380000403 dimer interface [polypeptide binding]; other site 637380000404 active site 637380000405 motif 1; other site 637380000406 motif 2; other site 637380000407 motif 3; other site 637380000408 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 637380000409 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 637380000410 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 637380000411 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673 637380000412 Substrate-binding site [chemical binding]; other site 637380000413 Substrate specificity [chemical binding]; other site 637380000414 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 637380000415 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673 637380000416 Substrate-binding site [chemical binding]; other site 637380000417 Substrate specificity [chemical binding]; other site 637380000418 Isochorismatase family; Region: Isochorismatase; pfam00857 637380000419 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 637380000420 catalytic triad [active] 637380000421 conserved cis-peptide bond; other site 637380000422 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 637380000423 nucleoside/Zn binding site; other site 637380000424 dimer interface [polypeptide binding]; other site 637380000425 catalytic motif [active] 637380000426 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 637380000427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380000428 Walker A motif; other site 637380000429 ATP binding site [chemical binding]; other site 637380000430 Walker B motif; other site 637380000431 arginine finger; other site 637380000432 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 637380000433 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 637380000434 recombination protein RecR; Reviewed; Region: recR; PRK00076 637380000435 RecR protein; Region: RecR; pfam02132 637380000436 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 637380000437 putative active site [active] 637380000438 putative metal-binding site [ion binding]; other site 637380000439 tetramer interface [polypeptide binding]; other site 637380000440 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 637380000441 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 637380000442 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 637380000443 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 637380000444 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and...; Region: Orn_deC_like; cd00615 637380000445 homodimer interface [polypeptide binding]; other site 637380000446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380000447 catalytic residue [active] 637380000448 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 637380000449 thymidylate kinase; Validated; Region: tmk; PRK00698 637380000450 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 637380000451 TMP-binding site; other site 637380000452 ATP-binding site [chemical binding]; other site 637380000453 DNA polymerase III subunit delta'; Validated; Region: PRK08058 637380000454 PSP1 C-terminal conserved region; Region: PSP1; cl00770 637380000455 Protein of unknown function (DUF972); Region: DUF972; cl01853 637380000456 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 637380000457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380000458 S-adenosylmethionine binding site [chemical binding]; other site 637380000459 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 637380000460 Predicted methyltransferases [General function prediction only]; Region: COG0313 637380000461 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 637380000462 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 637380000463 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 637380000464 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 637380000465 active site 637380000466 HIGH motif; other site 637380000467 KMSKS motif; other site 637380000468 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 637380000469 tRNA binding surface [nucleotide binding]; other site 637380000470 anticodon binding site; other site 637380000471 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 637380000472 dimer interface [polypeptide binding]; other site 637380000473 putative tRNA-binding site [nucleotide binding]; other site 637380000474 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 637380000475 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 637380000476 active site 637380000477 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 637380000478 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in...; Region: TOPRIM_RNase_M5_like; cd01027 637380000479 putative active site [active] 637380000480 putative metal binding site [ion binding]; other site 637380000481 Plant protein of unknown function (DUF825); Region: DUF825; pfam05695 637380000482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380000483 YabG peptidase U57; Region: Peptidase_U57; cl05250 637380000484 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 637380000485 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 637380000486 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 637380000487 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 637380000488 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 637380000489 pur operon repressor; Provisional; Region: PRK09213 637380000490 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 637380000491 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 637380000492 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 637380000493 homotrimer interaction site [polypeptide binding]; other site 637380000494 putative active site [active] 637380000495 SpoVG; Region: SpoVG; cl00915 637380000496 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 637380000497 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 637380000498 Substrate binding site [chemical binding]; other site 637380000499 Mg++ binding site [ion binding]; other site 637380000500 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 637380000501 active site 637380000502 substrate binding site [chemical binding]; other site 637380000503 CoA binding site [chemical binding]; other site 637380000504 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 637380000505 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 637380000506 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 637380000507 putative active site [active] 637380000508 catalytic residue [active] 637380000509 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 637380000510 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 637380000511 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 637380000512 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637380000513 ATP binding site [chemical binding]; other site 637380000514 putative Mg++ binding site [ion binding]; other site 637380000515 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637380000516 nucleotide binding region [chemical binding]; other site 637380000517 ATP-binding site [chemical binding]; other site 637380000518 TRCF domain; Region: TRCF; pfam03461 637380000519 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 637380000520 stage V sporulation protein T; Region: spore_V_T; TIGR02851 637380000521 stage V sporulation protein B; Region: spore_V_B; TIGR02900 637380000522 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 637380000523 potential frameshift: common BLAST hit: gi|218901258|ref|YP_002449092.1| tetrapyrrole methylase family protein/MazG family protein 637380000524 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 637380000525 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 637380000526 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 637380000527 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 637380000528 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 637380000529 YabP family; Region: YabP; cl06766 637380000530 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 637380000531 Septum formation initiator; Region: DivIC; cl11433 637380000532 hypothetical protein; Provisional; Region: PRK08582 637380000533 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 637380000534 RNA binding site [nucleotide binding]; other site 637380000535 stage II sporulation protein E; Region: spore_II_E; TIGR02865 637380000536 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 637380000537 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 637380000538 Ligand Binding Site [chemical binding]; other site 637380000539 TilS substrate binding domain; Region: TilS; pfam09179 637380000540 B3/4 domain; Region: B3_4; cl11458 637380000541 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 637380000542 FtsH Extracellular; Region: FtsH_ext; pfam06480 637380000543 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 637380000544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380000545 Walker A motif; other site 637380000546 ATP binding site [chemical binding]; other site 637380000547 Walker B motif; other site 637380000548 arginine finger; other site 637380000549 Peptidase family M41; Region: Peptidase_M41; pfam01434 637380000550 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 637380000551 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 637380000552 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 637380000553 dimerization interface [polypeptide binding]; other site 637380000554 domain crossover interface; other site 637380000555 redox-dependent activation switch; other site 637380000556 cysteine synthases; Region: cysKM; TIGR01136 637380000557 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 637380000558 dimer interface [polypeptide binding]; other site 637380000559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380000560 catalytic residue [active] 637380000561 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 637380000562 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 637380000563 chorismate binding enzyme; Region: Chorismate_bind; cl10555 637380000564 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 637380000565 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 637380000566 glutamine binding [chemical binding]; other site 637380000567 catalytic triad [active] 637380000568 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 637380000569 homodimer interface [polypeptide binding]; other site 637380000570 substrate-cofactor binding pocket; other site 637380000571 Aminotransferase class IV; Region: Aminotran_4; pfam01063 637380000572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380000573 catalytic residue [active] 637380000574 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 637380000575 dihydropteroate synthase; Region: DHPS; TIGR01496 637380000576 substrate binding pocket [chemical binding]; other site 637380000577 dimer interface [polypeptide binding]; other site 637380000578 inhibitor binding site; inhibition site 637380000579 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534 637380000580 homooctamer interface [polypeptide binding]; other site 637380000581 active site 637380000582 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 637380000583 catalytic center binding site [active] 637380000584 ATP binding site [chemical binding]; other site 637380000585 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380000586 non-specific DNA binding site [nucleotide binding]; other site 637380000587 salt bridge; other site 637380000588 sequence-specific DNA binding site [nucleotide binding]; other site 637380000589 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 637380000590 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 637380000591 FMN binding site [chemical binding]; other site 637380000592 active site 637380000593 catalytic residues [active] 637380000594 substrate binding site [chemical binding]; other site 637380000595 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 637380000596 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 637380000597 dimer interface [polypeptide binding]; other site 637380000598 putative anticodon binding site; other site 637380000599 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 637380000600 motif 1; other site 637380000601 active site 637380000602 motif 2; other site 637380000603 motif 3; other site 637380000604 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 637380000605 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 637380000606 UvrB/uvrC motif; Region: UVR; pfam02151 637380000607 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 637380000608 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 637380000609 ADP binding site [chemical binding]; other site 637380000610 phosphagen binding site; other site 637380000611 substrate specificity loop; other site 637380000612 Clp protease ATP binding subunit; Region: clpC; CHL00095 637380000613 Clp amino terminal domain; Region: Clp_N; pfam02861 637380000614 Clp amino terminal domain; Region: Clp_N; pfam02861 637380000615 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380000616 Walker A motif; other site 637380000617 ATP binding site [chemical binding]; other site 637380000618 Walker B motif; other site 637380000619 arginine finger; other site 637380000620 UvrB/uvrC motif; Region: UVR; pfam02151 637380000621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380000622 Walker A motif; other site 637380000623 ATP binding site [chemical binding]; other site 637380000624 Walker B motif; other site 637380000625 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 637380000626 DNA repair protein RadA; Provisional; Region: PRK11823 637380000627 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 637380000628 Walker A motif/ATP binding site; other site 637380000629 ATP binding site [chemical binding]; other site 637380000630 Walker B motif; other site 637380000631 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 637380000632 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 637380000633 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 637380000634 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 637380000635 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 637380000636 putative active site [active] 637380000637 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 637380000638 substrate binding site [chemical binding]; other site 637380000639 dimer interface [polypeptide binding]; other site 637380000640 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 637380000641 homotrimer interaction site [polypeptide binding]; other site 637380000642 zinc binding site [ion binding]; other site 637380000643 CDP-binding sites; other site 637380000644 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 637380000645 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 637380000646 active site 637380000647 HIGH motif; other site 637380000648 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 637380000649 active site 637380000650 KMSKS motif; other site 637380000651 serine O-acetyltransferase; Region: cysE; TIGR01172 637380000652 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 637380000653 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 637380000654 trimer interface [polypeptide binding]; other site 637380000655 active site 637380000656 substrate binding site [chemical binding]; other site 637380000657 CoA binding site [chemical binding]; other site 637380000658 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 637380000659 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 637380000660 active site 637380000661 HIGH motif; other site 637380000662 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 637380000663 KMSKS motif; other site 637380000664 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 637380000665 tRNA binding surface [nucleotide binding]; other site 637380000666 anticodon binding site; other site 637380000667 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cl00258 637380000668 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 637380000669 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 637380000670 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 637380000671 YacP-like NYN domain; Region: NYN_YacP; cl01491 637380000672 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 637380000673 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637380000674 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 637380000675 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 637380000676 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 637380000677 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 637380000678 putative homodimer interface [polypeptide binding]; other site 637380000679 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 637380000680 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 637380000681 23S rRNA interface [nucleotide binding]; other site 637380000682 L7/L12 interface [polypeptide binding]; other site 637380000683 putative thiostrepton binding site; other site 637380000684 L25 interface [polypeptide binding]; other site 637380000685 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 637380000686 mRNA/rRNA interface [nucleotide binding]; other site 637380000687 BACI_c01250; ribosomal protein L10 leader, RF00557 637380000688 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 637380000689 23S rRNA interface [nucleotide binding]; other site 637380000690 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 637380000691 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 637380000692 core dimer interface [polypeptide binding]; other site 637380000693 peripheral dimer interface [polypeptide binding]; other site 637380000694 L10 interface [polypeptide binding]; other site 637380000695 L11 interface [polypeptide binding]; other site 637380000696 putative EF-Tu interaction site [polypeptide binding]; other site 637380000697 putative EF-G interaction site [polypeptide binding]; other site 637380000698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380000699 S-adenosylmethionine binding site [chemical binding]; other site 637380000700 RNA polymerase beta subunit; Provisional; Region: rpoB; CHL00207 637380000701 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 637380000702 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 637380000703 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 637380000704 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 637380000705 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 637380000706 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 637380000707 RPB10 interaction site [polypeptide binding]; other site 637380000708 RPB1 interaction site [polypeptide binding]; other site 637380000709 RPB11 interaction site [polypeptide binding]; other site 637380000710 RPB3 interaction site [polypeptide binding]; other site 637380000711 RPB12 interaction site [polypeptide binding]; other site 637380000712 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 637380000713 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 637380000714 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 637380000715 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 637380000716 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 637380000717 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 637380000718 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 637380000719 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 637380000720 G-loop; other site 637380000721 DNA binding site [nucleotide binding] 637380000722 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 637380000723 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 637380000724 S17 interaction site [polypeptide binding]; other site 637380000725 S8 interaction site; other site 637380000726 16S rRNA interaction site [nucleotide binding]; other site 637380000727 streptomycin interaction site [chemical binding]; other site 637380000728 23S rRNA interaction site [nucleotide binding]; other site 637380000729 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 637380000730 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 637380000731 elongation factor G; Reviewed; Region: PRK00007 637380000732 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 637380000733 G1 box; other site 637380000734 putative GEF interaction site [polypeptide binding]; other site 637380000735 GTP/Mg2+ binding site [chemical binding]; other site 637380000736 Switch I region; other site 637380000737 G2 box; other site 637380000738 G3 box; other site 637380000739 Switch II region; other site 637380000740 G4 box; other site 637380000741 G5 box; other site 637380000742 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 637380000743 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 637380000744 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 637380000745 elongation factor Tu; Reviewed; Region: PRK00049 637380000746 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 637380000747 G1 box; other site 637380000748 GEF interaction site [polypeptide binding]; other site 637380000749 GTP/Mg2+ binding site [chemical binding]; other site 637380000750 Switch I region; other site 637380000751 G2 box; other site 637380000752 G3 box; other site 637380000753 Switch II region; other site 637380000754 G4 box; other site 637380000755 G5 box; other site 637380000756 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 637380000757 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 637380000758 Antibiotic Binding Site [chemical binding]; other site 637380000759 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 637380000760 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 637380000761 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 637380000762 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 637380000763 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 637380000764 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 637380000765 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 637380000766 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 637380000767 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 637380000768 putative translocon binding site; other site 637380000769 protein-rRNA interface [nucleotide binding]; other site 637380000770 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 637380000771 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 637380000772 G-X-X-G motif; other site 637380000773 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 637380000774 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 637380000775 23S rRNA interface [nucleotide binding]; other site 637380000776 5S rRNA interface [nucleotide binding]; other site 637380000777 putative antibiotic binding site [chemical binding]; other site 637380000778 L25 interface [polypeptide binding]; other site 637380000779 L27 interface [polypeptide binding]; other site 637380000780 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 637380000781 23S rRNA interface [nucleotide binding]; other site 637380000782 putative translocon interaction site; other site 637380000783 signal recognition particle (SRP54) interaction site; other site 637380000784 L23 interface [polypeptide binding]; other site 637380000785 trigger factor interaction site; other site 637380000786 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 637380000787 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 637380000788 KOW motif; Region: KOW; cl00354 637380000789 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 637380000790 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 637380000791 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 637380000792 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 637380000793 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 637380000794 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 637380000795 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 637380000796 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 637380000797 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 637380000798 5S rRNA interface [nucleotide binding]; other site 637380000799 L27 interface [polypeptide binding]; other site 637380000800 23S rRNA interface [nucleotide binding]; other site 637380000801 L5 interface [polypeptide binding]; other site 637380000802 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 637380000803 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 637380000804 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 637380000805 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 637380000806 23S rRNA binding site [nucleotide binding]; other site 637380000807 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 637380000808 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 637380000809 SecY translocase; Region: SecY; pfam00344 637380000810 adenylate kinase; Reviewed; Region: adk; PRK00279 637380000811 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 637380000812 AMP-binding site [chemical binding]; other site 637380000813 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 637380000814 methionine aminopeptidase; Reviewed; Region: PRK07281 637380000815 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 637380000816 active site 637380000817 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 637380000818 rRNA binding site [nucleotide binding]; other site 637380000819 predicted 30S ribosome binding site; other site 637380000820 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 637380000821 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 637380000822 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 637380000823 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 637380000824 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 637380000825 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 637380000826 alphaNTD - beta interaction site [polypeptide binding]; other site 637380000827 alphaNTD homodimer interface [polypeptide binding]; other site 637380000828 alphaNTD - beta' interaction site [polypeptide binding]; other site 637380000829 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 637380000830 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 637380000831 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 637380000832 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 637380000833 Walker A/P-loop; other site 637380000834 ATP binding site [chemical binding]; other site 637380000835 Q-loop/lid; other site 637380000836 ABC transporter signature motif; other site 637380000837 Walker B; other site 637380000838 D-loop; other site 637380000839 H-loop/switch region; other site 637380000840 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 637380000841 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 637380000842 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 637380000843 Walker A/P-loop; other site 637380000844 ATP binding site [chemical binding]; other site 637380000845 Q-loop/lid; other site 637380000846 ABC transporter signature motif; other site 637380000847 Walker B; other site 637380000848 D-loop; other site 637380000849 H-loop/switch region; other site 637380000850 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 637380000851 Cobalt transport protein; Region: CbiQ; cl00463 637380000852 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 637380000853 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 637380000854 dimerization interface 3.5A [polypeptide binding]; other site 637380000855 active site 637380000856 BACI_c01700; ribosomal protein L13 leader, RF00555 637380000857 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 637380000858 23S rRNA interface [nucleotide binding]; other site 637380000859 L3 interface [polypeptide binding]; other site 637380000860 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 637380000861 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 637380000862 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 637380000863 active site 637380000864 metal binding site [ion binding]; metal-binding site 637380000865 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 637380000866 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 637380000867 Glycerate kinase family; Region: Gly_kinase; cl00841 637380000868 Arginase family; Region: Arginase; cl00306 637380000869 Uncharacterized conserved protein [Function unknown]; Region: COG1624 637380000870 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 637380000871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 637380000872 YbbR-like protein; Region: YbbR; pfam07949 637380000873 YbbR-like protein; Region: YbbR; pfam07949 637380000874 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 637380000875 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 637380000876 active site 637380000877 substrate binding site [chemical binding]; other site 637380000878 metal binding site [ion binding]; metal-binding site 637380000879 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 637380000880 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 637380000881 glutaminase active site [active] 637380000882 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 637380000883 dimer interface [polypeptide binding]; other site 637380000884 active site 637380000885 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 637380000886 dimer interface [polypeptide binding]; other site 637380000887 active site 637380000888 Beta-lactamase; Region: Beta-lactamase; cl01009 637380000889 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637380000890 Transcriptional regulators [Transcription]; Region: GntR; COG1802 637380000891 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637380000892 DNA-binding site [nucleotide binding]; DNA binding site 637380000893 FCD domain; Region: FCD; cl11656 637380000894 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 637380000895 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 637380000896 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 637380000897 gluconate transporter; Region: gntP; TIGR00791 637380000898 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380000899 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380000900 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 637380000901 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 637380000902 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 637380000903 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 637380000904 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380000905 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 637380000906 classical (c) SDRs; Region: SDR_c; cd05233 637380000907 NAD(P) binding site [chemical binding]; other site 637380000908 active site 637380000909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380000910 ABC-ATPase subunit interface; other site 637380000911 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 637380000912 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 637380000913 Walker A/P-loop; other site 637380000914 ATP binding site [chemical binding]; other site 637380000915 Q-loop/lid; other site 637380000916 ABC transporter signature motif; other site 637380000917 Walker B; other site 637380000918 D-loop; other site 637380000919 H-loop/switch region; other site 637380000920 NIL domain; Region: NIL; pfam09383 637380000921 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380000922 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 637380000923 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 637380000924 putative NAD(P) binding site [chemical binding]; other site 637380000925 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 637380000926 FAD binding domain; Region: FAD_binding_4; pfam01565 637380000927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380000928 putative substrate translocation pore; other site 637380000929 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 637380000930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380000931 putative substrate translocation pore; other site 637380000932 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 637380000933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380000934 dimer interface [polypeptide binding]; other site 637380000935 conserved gate region; other site 637380000936 putative PBP binding loops; other site 637380000937 ABC-ATPase subunit interface; other site 637380000938 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 637380000939 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 637380000940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380000941 dimer interface [polypeptide binding]; other site 637380000942 conserved gate region; other site 637380000943 putative PBP binding loops; other site 637380000944 ABC-ATPase subunit interface; other site 637380000945 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 637380000946 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 637380000947 Walker A/P-loop; other site 637380000948 ATP binding site [chemical binding]; other site 637380000949 Q-loop/lid; other site 637380000950 ABC transporter signature motif; other site 637380000951 Walker B; other site 637380000952 D-loop; other site 637380000953 H-loop/switch region; other site 637380000954 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 637380000955 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 637380000956 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 637380000957 Walker A/P-loop; other site 637380000958 ATP binding site [chemical binding]; other site 637380000959 Q-loop/lid; other site 637380000960 ABC transporter signature motif; other site 637380000961 Walker B; other site 637380000962 D-loop; other site 637380000963 H-loop/switch region; other site 637380000964 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 637380000965 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 637380000966 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637380000967 peptide binding site [polypeptide binding]; other site 637380000968 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637380000969 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637380000970 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637380000971 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 637380000972 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 637380000973 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637380000974 peptide binding site [polypeptide binding]; other site 637380000975 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 637380000976 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637380000977 peptide binding site [polypeptide binding]; other site 637380000978 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 637380000979 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637380000980 active site 637380000981 catalytic tetrad [active] 637380000982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380000983 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 637380000984 Sugar transport protein; Region: Sugar_transport; pfam06800 637380000985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380000986 dimer interface [polypeptide binding]; other site 637380000987 conserved gate region; other site 637380000988 putative PBP binding loops; other site 637380000989 ABC-ATPase subunit interface; other site 637380000990 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380000991 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 637380000992 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380000993 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637380000994 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380000995 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 637380000996 putative dimerization interface [polypeptide binding]; other site 637380000997 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637380000998 Transposase [DNA replication, recombination, and repair]; Region: COG5421 637380000999 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 637380001000 putative acyl-acceptor binding pocket; other site 637380001001 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637380001002 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637380001003 DNA binding site [nucleotide binding] 637380001004 domain linker motif; other site 637380001005 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 637380001006 putative ligand binding site [chemical binding]; other site 637380001007 putative dimerization interface [polypeptide binding]; other site 637380001008 Uncharacterized conserved protein [Function unknown]; Region: COG1284 637380001009 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637380001010 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637380001011 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 637380001012 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 637380001013 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 637380001014 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 637380001015 active site 637380001016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5298 637380001017 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 637380001018 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 637380001019 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637380001020 catalytic residue [active] 637380001021 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 637380001022 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 637380001023 nucleotide binding site/active site [active] 637380001024 HIT family signature motif; other site 637380001025 catalytic residue [active] 637380001026 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 637380001027 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637380001028 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380001029 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637380001030 ABC transporter; Region: ABC_tran_2; pfam12848 637380001031 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637380001032 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 637380001033 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 637380001034 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 637380001035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380001036 dimer interface [polypeptide binding]; other site 637380001037 conserved gate region; other site 637380001038 putative PBP binding loops; other site 637380001039 ABC-ATPase subunit interface; other site 637380001040 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 637380001041 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 637380001042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380001043 dimer interface [polypeptide binding]; other site 637380001044 conserved gate region; other site 637380001045 putative PBP binding loops; other site 637380001046 ABC-ATPase subunit interface; other site 637380001047 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 637380001048 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 637380001049 Walker A/P-loop; other site 637380001050 ATP binding site [chemical binding]; other site 637380001051 Q-loop/lid; other site 637380001052 ABC transporter signature motif; other site 637380001053 Walker B; other site 637380001054 D-loop; other site 637380001055 H-loop/switch region; other site 637380001056 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 637380001057 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 637380001058 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 637380001059 Walker A/P-loop; other site 637380001060 ATP binding site [chemical binding]; other site 637380001061 Q-loop/lid; other site 637380001062 ABC transporter signature motif; other site 637380001063 Walker B; other site 637380001064 D-loop; other site 637380001065 H-loop/switch region; other site 637380001066 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 637380001067 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637380001068 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637380001069 active site 637380001070 motif I; other site 637380001071 motif II; other site 637380001072 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637380001073 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 637380001074 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 637380001075 dimer interface [polypeptide binding]; other site 637380001076 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 637380001077 active site 637380001078 Fe binding site [ion binding]; other site 637380001079 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 637380001080 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 637380001081 homogentisate 1,2-dioxygenase; Region: HgmA; cl10473 637380001082 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380001083 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 637380001084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380001085 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637380001086 putative substrate translocation pore; other site 637380001087 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 637380001088 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 637380001089 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 637380001090 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 637380001091 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 637380001092 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637380001093 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637380001094 helicase 45; Provisional; Region: PTZ00424 637380001095 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 637380001096 ATP binding site [chemical binding]; other site 637380001097 Mg++ binding site [ion binding]; other site 637380001098 motif III; other site 637380001099 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637380001100 nucleotide binding region [chemical binding]; other site 637380001101 ATP-binding site [chemical binding]; other site 637380001102 UV-endonuclease UvdE; Region: UvdE; cl10036 637380001103 Rhomboid family; Region: Rhomboid; cl11446 637380001104 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 637380001105 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 637380001106 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 637380001107 alanine racemase; Reviewed; Region: alr; PRK00053 637380001108 active site 637380001109 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637380001110 dimer interface [polypeptide binding]; other site 637380001111 substrate binding site [chemical binding]; other site 637380001112 catalytic residues [active] 637380001113 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 637380001114 PemK-like protein; Region: PemK; cl00995 637380001115 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 637380001116 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 637380001117 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 637380001118 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 637380001119 RNA binding site [nucleotide binding]; other site 637380001120 SprT homologues; Region: SprT; cl01182 637380001121 SprT-like family; Region: SprT-like; pfam10263 637380001122 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 637380001123 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 637380001124 Glycoprotease family; Region: Peptidase_M22; pfam00814 637380001125 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 637380001126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380001127 Coenzyme A binding pocket [chemical binding]; other site 637380001128 UGMP family protein; Validated; Region: PRK09604 637380001129 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 637380001130 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 637380001131 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637380001132 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380001133 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637380001134 ABC transporter; Region: ABC_tran_2; pfam12848 637380001135 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637380001136 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 637380001137 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 637380001138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380001139 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 637380001140 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 637380001141 oligomerisation interface [polypeptide binding]; other site 637380001142 mobile loop; other site 637380001143 roof hairpin; other site 637380001144 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 637380001145 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 637380001146 ring oligomerisation interface [polypeptide binding]; other site 637380001147 ATP/Mg binding site [chemical binding]; other site 637380001148 stacking interactions; other site 637380001149 hinge regions; other site 637380001150 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 637380001151 GMP synthase; Reviewed; Region: guaA; PRK00074 637380001152 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 637380001153 AMP/PPi binding site [chemical binding]; other site 637380001154 candidate oxyanion hole; other site 637380001155 catalytic triad [active] 637380001156 potential glutamine specificity residues [chemical binding]; other site 637380001157 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 637380001158 ATP Binding subdomain [chemical binding]; other site 637380001159 Ligand Binding sites [chemical binding]; other site 637380001160 Dimerization subdomain; other site 637380001161 Sulfate transporter family; Region: Sulfate_transp; cl00967 637380001162 Permease family; Region: Xan_ur_permease; pfam00860 637380001163 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380001164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380001165 active site 637380001166 phosphorylation site [posttranslational modification] 637380001167 intermolecular recognition site; other site 637380001168 dimerization interface [polypeptide binding]; other site 637380001169 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380001170 DNA binding site [nucleotide binding] 637380001171 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 637380001172 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380001173 dimer interface [polypeptide binding]; other site 637380001174 phosphorylation site [posttranslational modification] 637380001175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380001176 ATP binding site [chemical binding]; other site 637380001177 Mg2+ binding site [ion binding]; other site 637380001178 G-X-G motif; other site 637380001179 potential frameshift: common BLAST hit: gi|218901470|ref|YP_002449304.1| UDP-glucose 4-epimerase 637380001180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380001181 NAD(P) binding site [chemical binding]; other site 637380001182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380001183 AIR carboxylase; Region: AIRC; cl00310 637380001184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380001185 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 637380001186 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 637380001187 adenylosuccinate lyase; Provisional; Region: PRK07492 637380001188 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 637380001189 tetramer interface [polypeptide binding]; other site 637380001190 active site 637380001191 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 637380001192 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 637380001193 ATP binding site [chemical binding]; other site 637380001194 active site 637380001195 substrate binding site [chemical binding]; other site 637380001196 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 637380001197 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 637380001198 putative active site [active] 637380001199 catalytic triad [active] 637380001200 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 637380001201 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 637380001202 dimerization interface [polypeptide binding]; other site 637380001203 ATP binding site [chemical binding]; other site 637380001204 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 637380001205 dimerization interface [polypeptide binding]; other site 637380001206 ATP binding site [chemical binding]; other site 637380001207 amidophosphoribosyltransferase; Provisional; Region: PRK06781 637380001208 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 637380001209 active site 637380001210 tetramer interface [polypeptide binding]; other site 637380001211 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 637380001212 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 637380001213 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 637380001214 dimerization interface [polypeptide binding]; other site 637380001215 putative ATP binding site [chemical binding]; other site 637380001216 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 637380001217 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 637380001218 active site 637380001219 substrate binding site [chemical binding]; other site 637380001220 cosubstrate binding site; other site 637380001221 catalytic site [active] 637380001222 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 637380001223 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 637380001224 purine monophosphate binding site [chemical binding]; other site 637380001225 dimer interface [polypeptide binding]; other site 637380001226 putative catalytic residues [active] 637380001227 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 637380001228 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 637380001229 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 637380001230 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 637380001231 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 637380001232 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 637380001233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 637380001234 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 637380001235 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 637380001236 Predicted phosphate-binding enzymes, TIM-barrel fold [General function prediction only]; Region: COG1646 637380001237 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between sn-glycerol-1-...; Region: PcrB_like; cd02812 637380001238 substrate binding site [chemical binding]; other site 637380001239 putative active site [active] 637380001240 dimer interface [polypeptide binding]; other site 637380001241 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 637380001242 UvrD/REP helicase; Region: UvrD-helicase; cl14126 637380001243 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 637380001244 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 637380001245 nucleotide binding pocket [chemical binding]; other site 637380001246 K-X-D-G motif; other site 637380001247 catalytic site [active] 637380001248 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 637380001249 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 637380001250 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 637380001251 Dimer interface [polypeptide binding]; other site 637380001252 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 637380001253 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 637380001254 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 637380001255 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 637380001256 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 637380001257 Glutamate binding site [chemical binding]; other site 637380001258 homodimer interface [polypeptide binding]; other site 637380001259 NAD binding site [chemical binding]; other site 637380001260 catalytic residues [active] 637380001261 Isochorismatase family; Region: Isochorismatase; pfam00857 637380001262 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 637380001263 catalytic triad [active] 637380001264 conserved cis-peptide bond; other site 637380001265 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 637380001266 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 637380001267 Walker A/P-loop; other site 637380001268 ATP binding site [chemical binding]; other site 637380001269 Q-loop/lid; other site 637380001270 ABC transporter signature motif; other site 637380001271 Walker B; other site 637380001272 D-loop; other site 637380001273 H-loop/switch region; other site 637380001274 NIL domain; Region: NIL; pfam09383 637380001275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380001276 dimer interface [polypeptide binding]; other site 637380001277 conserved gate region; other site 637380001278 ABC-ATPase subunit interface; other site 637380001279 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380001280 potential frameshift: common BLAST hit: gi|218901507|ref|YP_002449341.1| anion-transporting ATPase family protein 637380001281 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 637380001282 putative dimer interface [polypeptide binding]; other site 637380001283 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 637380001284 ATP binding site [chemical binding]; other site 637380001285 dimerization interface [polypeptide binding]; other site 637380001286 Metal binding site [ion binding]; metal-binding site 637380001287 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380001288 yiaA/B two helix domain; Region: YiaAB; cl01759 637380001289 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 637380001290 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 637380001291 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 637380001292 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 637380001293 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 637380001294 GatB domain; Region: GatB_Yqey; cl11497 637380001295 putative lipid kinase; Reviewed; Region: PRK13337 637380001296 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 637380001297 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 637380001298 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637380001299 motif II; other site 637380001300 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 637380001301 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 637380001302 inhibitor-cofactor binding pocket; inhibition site 637380001303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380001304 catalytic residue [active] 637380001305 PAS fold; Region: PAS_4; pfam08448 637380001306 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637380001307 putative active site [active] 637380001308 heme pocket [chemical binding]; other site 637380001309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380001310 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 637380001311 Walker A motif; other site 637380001312 ATP binding site [chemical binding]; other site 637380001313 Walker B motif; other site 637380001314 arginine finger; other site 637380001315 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 637380001316 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 637380001317 tetramerization interface [polypeptide binding]; other site 637380001318 NAD(P) binding site [chemical binding]; other site 637380001319 catalytic residues [active] 637380001320 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 637380001321 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 637380001322 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 637380001323 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 637380001324 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 637380001325 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 637380001326 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 637380001327 TRAM domain; Region: TRAM; cl01282 637380001328 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 637380001329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380001330 S-adenosylmethionine binding site [chemical binding]; other site 637380001331 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 637380001332 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 637380001333 FMN binding site [chemical binding]; other site 637380001334 active site 637380001335 catalytic residues [active] 637380001336 substrate binding site [chemical binding]; other site 637380001337 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 637380001338 GAF domain; Region: GAF; cl00853 637380001339 sensory histidine kinase AtoS; Provisional; Region: PRK11360 637380001340 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380001341 dimer interface [polypeptide binding]; other site 637380001342 phosphorylation site [posttranslational modification] 637380001343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380001344 ATP binding site [chemical binding]; other site 637380001345 Mg2+ binding site [ion binding]; other site 637380001346 G-X-G motif; other site 637380001347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 637380001348 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 637380001349 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 637380001350 Protein of unknown function DUF45; Region: DUF45; cl00636 637380001351 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 637380001352 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism...; Region: L-Ala-DL-Glu_epimerase; cd03319 637380001353 active site 637380001354 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 637380001355 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380001356 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380001357 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 637380001358 amidohydrolase; Region: amidohydrolases; TIGR01891 637380001359 metal binding site [ion binding]; metal-binding site 637380001360 putative dimer interface [polypeptide binding]; other site 637380001361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380001362 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 637380001363 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the...; Region: AhpF_NTD_N; cd02974 637380001364 catalytic residue [active] 637380001365 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 637380001366 catalytic residues [active] 637380001367 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380001368 peroxiredoxin; Region: AhpC; TIGR03137 637380001369 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 637380001370 dimer interface [polypeptide binding]; other site 637380001371 decamer (pentamer of dimers) interface [polypeptide binding]; other site 637380001372 catalytic triad [active] 637380001373 peroxidatic and resolving cysteines [active] 637380001374 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637380001375 Phosphotransferase enzyme family; Region: APH; pfam01636 637380001376 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 637380001377 Initiation factor 2 subunit family; Region: IF-2B; pfam01008 637380001378 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 637380001379 intersubunit interface [polypeptide binding]; other site 637380001380 active site 637380001381 Zn2+ binding site [ion binding]; other site 637380001382 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 637380001383 ABC-ATPase subunit interface; other site 637380001384 dimer interface [polypeptide binding]; other site 637380001385 putative PBP binding regions; other site 637380001386 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 637380001387 ABC-ATPase subunit interface; other site 637380001388 dimer interface [polypeptide binding]; other site 637380001389 putative PBP binding regions; other site 637380001390 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 637380001391 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: FeuA; cd01138 637380001392 putative ligand binding residues [chemical binding]; other site 637380001393 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 637380001394 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380001395 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 637380001396 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 637380001397 Putative cyclase; Region: Cyclase; cl00814 637380001398 hypothetical protein; Provisional; Region: PRK06851 637380001399 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380001400 Walker A motif; other site 637380001401 ATP binding site [chemical binding]; other site 637380001402 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380001403 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 637380001404 benzoate transport; Region: 2A0115; TIGR00895 637380001405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380001406 putative substrate translocation pore; other site 637380001407 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 637380001408 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 637380001409 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 637380001410 [2Fe-2S] cluster binding site [ion binding]; other site 637380001411 Fatty acid desaturase; Region: FA_desaturase; pfam00487 637380001412 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These...; Region: Delta6-FADS-like; cd03506 637380001413 putative di-iron ligands [ion binding]; other site 637380001414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380001415 dimer interface [polypeptide binding]; other site 637380001416 conserved gate region; other site 637380001417 putative PBP binding loops; other site 637380001418 ABC-ATPase subunit interface; other site 637380001419 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637380001420 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 637380001421 substrate binding pocket [chemical binding]; other site 637380001422 membrane-bound complex binding site; other site 637380001423 hinge residues; other site 637380001424 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637380001425 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 637380001426 Walker A/P-loop; other site 637380001427 ATP binding site [chemical binding]; other site 637380001428 Q-loop/lid; other site 637380001429 ABC transporter signature motif; other site 637380001430 Walker B; other site 637380001431 D-loop; other site 637380001432 H-loop/switch region; other site 637380001433 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 637380001434 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 637380001435 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 637380001436 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 637380001437 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 637380001438 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637380001439 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 637380001440 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 637380001441 active site turn [active] 637380001442 phosphorylation site [posttranslational modification] 637380001443 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 637380001444 putative catalytic site [active] 637380001445 putative metal binding site [ion binding]; other site 637380001446 putative phosphate binding site [ion binding]; other site 637380001447 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 637380001448 Predicted membrane protein [Function unknown]; Region: COG1511 637380001449 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637380001450 DNA topoisomerase III; Provisional; Region: PRK07726 637380001451 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362 637380001452 active site 637380001453 putative interdomain interaction site [polypeptide binding]; other site 637380001454 putative metal-binding site [ion binding]; other site 637380001455 putative nucleotide binding site [chemical binding]; other site 637380001456 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 637380001457 domain I; other site 637380001458 DNA binding groove [nucleotide binding] 637380001459 phosphate binding site [ion binding]; other site 637380001460 domain II; other site 637380001461 domain III; other site 637380001462 nucleotide binding site [chemical binding]; other site 637380001463 catalytic site [active] 637380001464 domain IV; other site 637380001465 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 637380001466 substrate binding site [chemical binding]; other site 637380001467 multimerization interface [polypeptide binding]; other site 637380001468 ATP binding site [chemical binding]; other site 637380001469 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 637380001470 thiamine phosphate binding site [chemical binding]; other site 637380001471 active site 637380001472 pyrophosphate binding site [ion binding]; other site 637380001473 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 637380001474 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 637380001475 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637380001476 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 637380001477 Domain of unknown function DUF77; Region: DUF77; cl00307 637380001478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380001479 dimer interface [polypeptide binding]; other site 637380001480 conserved gate region; other site 637380001481 putative PBP binding loops; other site 637380001482 ABC-ATPase subunit interface; other site 637380001483 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 637380001484 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380001485 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 637380001486 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 637380001487 Walker A/P-loop; other site 637380001488 ATP binding site [chemical binding]; other site 637380001489 Q-loop/lid; other site 637380001490 ABC transporter signature motif; other site 637380001491 Walker B; other site 637380001492 D-loop; other site 637380001493 H-loop/switch region; other site 637380001494 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 637380001495 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380001496 Walker A/P-loop; other site 637380001497 ATP binding site [chemical binding]; other site 637380001498 Q-loop/lid; other site 637380001499 ABC transporter signature motif; other site 637380001500 Walker B; other site 637380001501 D-loop; other site 637380001502 H-loop/switch region; other site 637380001503 ABC transporter; Region: ABC_tran_2; pfam12848 637380001504 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637380001505 Glycosyl hydrolase family 18; Region: Glyco_18; smart00636 637380001506 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is...; Region: GH18_chitinase; cd06548 637380001507 active site 637380001508 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637380001509 Interdomain contacts; other site 637380001510 Cytokine receptor motif; other site 637380001511 Cellulose binding domain; Region: CBM_2; cl02709 637380001512 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 637380001513 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 637380001514 catalytic residues [active] 637380001515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380001516 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 637380001517 H+ Antiporter protein; Region: 2A0121; TIGR00900 637380001518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380001519 putative substrate translocation pore; other site 637380001520 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380001521 non-specific DNA binding site [nucleotide binding]; other site 637380001522 salt bridge; other site 637380001523 sequence-specific DNA binding site [nucleotide binding]; other site 637380001524 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 637380001525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380001526 putative substrate translocation pore; other site 637380001527 Sulfatase; Region: Sulfatase; cl10460 637380001528 prolyl-tRNA synthetase; Provisional; Region: PRK08661 637380001529 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_arch_euk; cd00778 637380001530 dimer interface [polypeptide binding]; other site 637380001531 motif 1; other site 637380001532 active site 637380001533 motif 2; other site 637380001534 motif 3; other site 637380001535 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity...; Region: ProRS_anticodon_zinc; cd00862 637380001536 anticodon binding site; other site 637380001537 zinc-binding site [ion binding]; other site 637380001538 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 637380001539 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 637380001540 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 637380001541 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 637380001542 putative metal binding site [ion binding]; other site 637380001543 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 637380001544 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 637380001545 putative metal binding site [ion binding]; other site 637380001546 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 637380001547 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 637380001548 putative metal binding site [ion binding]; other site 637380001549 Integral membrane protein TerC family; Region: TerC; cl10468 637380001550 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 637380001551 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 637380001552 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 637380001553 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637380001554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637380001555 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 637380001556 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 637380001557 Low molecular weight phosphatase family; Region: LMWPc; cd00115 637380001558 Active site [active] 637380001559 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 637380001560 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 637380001561 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637380001562 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637380001563 EamA-like transporter family; Region: EamA; cl01037 637380001564 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 637380001565 EamA-like transporter family; Region: EamA; cl01037 637380001566 YhhN-like protein; Region: YhhN; cl01505 637380001567 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637380001568 Catalytic site [active] 637380001569 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637380001570 binding surface 637380001571 TPR motif; other site 637380001572 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 637380001573 EamA-like transporter family; Region: EamA; cl01037 637380001574 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 637380001575 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 637380001576 calcium/proton exchanger (cax); Region: cax; TIGR00378 637380001577 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 637380001578 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 637380001579 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 637380001580 YfkB-like domain; Region: YfkB; pfam08756 637380001581 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 637380001582 Fumarase C-terminus; Region: Fumerase_C; cl00795 637380001583 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 637380001584 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 637380001585 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 637380001586 endonuclease III; Region: ENDO3c; smart00478 637380001587 minor groove reading motif; other site 637380001588 helix-hairpin-helix signature motif; other site 637380001589 substrate binding pocket [chemical binding]; other site 637380001590 active site 637380001591 TRAM domain; Region: TRAM; cl01282 637380001592 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 637380001593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380001594 S-adenosylmethionine binding site [chemical binding]; other site 637380001595 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 637380001596 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 637380001597 dimerization interface 3.5A [polypeptide binding]; other site 637380001598 active site 637380001599 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 637380001600 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380001601 Walker A motif; other site 637380001602 ATP binding site [chemical binding]; other site 637380001603 Walker B motif; other site 637380001604 arginine finger; other site 637380001605 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 637380001606 hypothetical protein; Validated; Region: PRK06748; cl11582 637380001607 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380001608 Amino acid permease; Region: AA_permease; pfam00324 637380001609 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 637380001610 M28, and M42; Region: Zinc_peptidase_like; cl14876 637380001611 metal binding site [ion binding]; metal-binding site 637380001612 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380001613 non-specific DNA binding site [nucleotide binding]; other site 637380001614 salt bridge; other site 637380001615 sequence-specific DNA binding site [nucleotide binding]; other site 637380001616 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 637380001617 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 637380001618 Glutaminase; Region: Glutaminase; cl00907 637380001619 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 637380001620 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637380001621 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637380001622 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 637380001623 active site turn [active] 637380001624 phosphorylation site [posttranslational modification] 637380001625 Beta-lactamase; Region: Beta-lactamase; cl01009 637380001626 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 637380001627 Ligand binding site [chemical binding]; other site 637380001628 Putative Catalytic site [active] 637380001629 DXD motif; other site 637380001630 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 637380001631 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 637380001632 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380001633 NAD(P) binding site [chemical binding]; other site 637380001634 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 637380001635 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 637380001636 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 637380001637 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380001638 NAD(P) binding site [chemical binding]; other site 637380001639 active site 637380001640 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 637380001641 active site 637380001642 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 637380001643 active site 637380001644 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 637380001645 Pyruvate formate lyase 1; Region: PFL1; cd01678 637380001646 coenzyme A binding site [chemical binding]; other site 637380001647 active site 637380001648 catalytic residues [active] 637380001649 glycine loop; other site 637380001650 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 637380001651 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 637380001652 FeS/SAM binding site; other site 637380001653 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 637380001654 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 637380001655 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380001656 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 637380001657 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 637380001658 active site 637380001659 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 637380001660 TIGR01777 family protein; Region: yfcH 637380001661 putative NAD(P) binding site [chemical binding]; other site 637380001662 putative active site [active] 637380001663 RecX family; Region: RecX; cl00936 637380001664 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 637380001665 Small acid-soluble spore protein K family; Region: SspK; cl11509 637380001666 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 637380001667 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 637380001668 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 637380001669 minor groove reading motif; other site 637380001670 helix-hairpin-helix signature motif; other site 637380001671 substrate binding pocket [chemical binding]; other site 637380001672 active site 637380001673 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 637380001674 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 637380001675 DNA binding and oxoG recognition site [nucleotide binding] 637380001676 Protein of unknown function (DUF402); Region: DUF402; cl00979 637380001677 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637380001678 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637380001679 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 637380001680 Walker A/P-loop; other site 637380001681 ATP binding site [chemical binding]; other site 637380001682 Q-loop/lid; other site 637380001683 ABC transporter signature motif; other site 637380001684 Walker B; other site 637380001685 D-loop; other site 637380001686 H-loop/switch region; other site 637380001687 Predicted membrane protein [Function unknown]; Region: COG4129 637380001688 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 637380001689 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 637380001690 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 637380001691 active site 637380001692 dimer interface [polypeptide binding]; other site 637380001693 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 637380001694 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 637380001695 active site 637380001696 FMN binding site [chemical binding]; other site 637380001697 substrate binding site [chemical binding]; other site 637380001698 3Fe-4S cluster binding site [ion binding]; other site 637380001699 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 637380001700 domain_subunit interface; other site 637380001701 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 637380001702 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 637380001703 inhibitor-cofactor binding pocket; inhibition site 637380001704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380001705 catalytic residue [active] 637380001706 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 637380001707 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380001708 Walker A/P-loop; other site 637380001709 ATP binding site [chemical binding]; other site 637380001710 Q-loop/lid; other site 637380001711 ABC transporter signature motif; other site 637380001712 Walker B; other site 637380001713 D-loop; other site 637380001714 H-loop/switch region; other site 637380001715 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 637380001716 Protein of unknown function (DUF990); Region: DUF990; cl01496 637380001717 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 637380001718 Protein of unknown function (DUF990); Region: DUF990; cl01496 637380001719 Ion channel; Region: Ion_trans_2; cl11596 637380001720 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 637380001721 catalytic triad [active] 637380001722 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 637380001723 metal binding site 2 [ion binding]; metal-binding site 637380001724 putative DNA binding helix; other site 637380001725 metal binding site 1 [ion binding]; metal-binding site 637380001726 dimer interface [polypeptide binding]; other site 637380001727 structural Zn2+ binding site [ion binding]; other site 637380001728 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 637380001729 Domain of unknown function DUF28; Region: DUF28; cl00361 637380001730 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 637380001731 nudix motif; other site 637380001732 Transglycosylase; Region: Transgly; cl07896 637380001733 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 637380001734 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 637380001735 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 637380001736 Putative amidase domain; Region: Amidase_6; pfam12671 637380001737 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 637380001738 PAS fold; Region: PAS_4; pfam08448 637380001739 PAS domain S-box; Region: sensory_box; TIGR00229 637380001740 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637380001741 putative active site [active] 637380001742 heme pocket [chemical binding]; other site 637380001743 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637380001744 metal binding site [ion binding]; metal-binding site 637380001745 active site 637380001746 I-site; other site 637380001747 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637380001748 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 637380001749 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380001750 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 637380001751 Protein of unknown function (DUF444); Region: DUF444; pfam04285 637380001752 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 637380001753 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 637380001754 heme-binding site [chemical binding]; other site 637380001755 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 637380001756 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 637380001757 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl14636 637380001758 Leucine-rich repeats; other site 637380001759 Substrate binding site [chemical binding]; other site 637380001760 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 637380001761 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380001762 BCCT family transporter; Region: BCCT; cl00569 637380001763 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 637380001764 Collagenase; Region: Peptidase_M9; pfam01752 637380001765 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 637380001766 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 637380001767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 637380001768 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins...; Region: Band_7_flotillin; cd03399 637380001769 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 637380001770 Cache domain; Region: Cache_1; pfam02743 637380001771 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 637380001772 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637380001773 dimerization interface [polypeptide binding]; other site 637380001774 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637380001775 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 637380001776 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 637380001777 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 637380001778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380001779 ATP binding site [chemical binding]; other site 637380001780 Mg2+ binding site [ion binding]; other site 637380001781 G-X-G motif; other site 637380001782 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 637380001783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380001784 active site 637380001785 phosphorylation site [posttranslational modification] 637380001786 intermolecular recognition site; other site 637380001787 dimerization interface [polypeptide binding]; other site 637380001788 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380001789 Citrate transporter; Region: CitMHS; pfam03600 637380001790 hypothetical protein; Validated; Region: PRK06748; cl11582 637380001791 NosL; Region: NosL; cl01769 637380001792 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 637380001793 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 637380001794 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 637380001795 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 637380001796 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 637380001797 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 637380001798 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 637380001799 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380001800 Walker A/P-loop; other site 637380001801 ATP binding site [chemical binding]; other site 637380001802 Q-loop/lid; other site 637380001803 ABC transporter signature motif; other site 637380001804 Walker B; other site 637380001805 D-loop; other site 637380001806 H-loop/switch region; other site 637380001807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 637380001808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380001809 dimer interface [polypeptide binding]; other site 637380001810 putative PBP binding loops; other site 637380001811 ABC-ATPase subunit interface; other site 637380001812 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637380001813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 637380001814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380001815 dimer interface [polypeptide binding]; other site 637380001816 conserved gate region; other site 637380001817 putative PBP binding loops; other site 637380001818 ABC-ATPase subunit interface; other site 637380001819 potential frameshift: common BLAST hit: gi|49476836|ref|YP_034828.1| glycerol-3-phosphate ABC transporter 637380001820 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380001821 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380001822 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637380001823 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 637380001824 active site 637380001825 metal binding site [ion binding]; metal-binding site 637380001826 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380001827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380001828 active site 637380001829 phosphorylation site [posttranslational modification] 637380001830 intermolecular recognition site; other site 637380001831 dimerization interface [polypeptide binding]; other site 637380001832 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380001833 DNA binding site [nucleotide binding] 637380001834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380001835 dimer interface [polypeptide binding]; other site 637380001836 phosphorylation site [posttranslational modification] 637380001837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380001838 ATP binding site [chemical binding]; other site 637380001839 Mg2+ binding site [ion binding]; other site 637380001840 G-X-G motif; other site 637380001841 leucyl-tRNA synthetase; Reviewed; Region: leuS; PRK12300 637380001842 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 637380001843 putative active site [active] 637380001844 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 637380001845 Cache domain; Region: Cache_1; pfam02743 637380001846 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 637380001847 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637380001848 dimerization interface [polypeptide binding]; other site 637380001849 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637380001850 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 637380001851 sensory histidine kinase DcuS; Provisional; Region: PRK11086 637380001852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380001853 ATP binding site [chemical binding]; other site 637380001854 Mg2+ binding site [ion binding]; other site 637380001855 G-X-G motif; other site 637380001856 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 637380001857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380001858 active site 637380001859 phosphorylation site [posttranslational modification] 637380001860 intermolecular recognition site; other site 637380001861 dimerization interface [polypeptide binding]; other site 637380001862 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 637380001863 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 637380001864 Malic enzyme, N-terminal domain; Region: malic; pfam00390 637380001865 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 637380001866 putative NAD(P) binding site [chemical binding]; other site 637380001867 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 637380001868 EamA-like transporter family; Region: EamA; cl01037 637380001869 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 637380001870 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637380001871 DNA-binding site [nucleotide binding]; DNA binding site 637380001872 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637380001873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380001874 homodimer interface [polypeptide binding]; other site 637380001875 catalytic residue [active] 637380001876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380001877 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380001878 Coenzyme A binding pocket [chemical binding]; other site 637380001879 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 637380001880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380001881 dimer interface [polypeptide binding]; other site 637380001882 phosphorylation site [posttranslational modification] 637380001883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380001884 ATP binding site [chemical binding]; other site 637380001885 Mg2+ binding site [ion binding]; other site 637380001886 G-X-G motif; other site 637380001887 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380001888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380001889 active site 637380001890 phosphorylation site [posttranslational modification] 637380001891 intermolecular recognition site; other site 637380001892 dimerization interface [polypeptide binding]; other site 637380001893 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380001894 DNA binding site [nucleotide binding] 637380001895 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380001896 Arrestin_N terminal like; Region: LDB19; pfam13002 637380001897 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380001898 Coenzyme A binding pocket [chemical binding]; other site 637380001899 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 637380001900 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 637380001901 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 637380001902 4Fe-4S binding domain; Region: Fer4; cl02805 637380001903 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H)...; Region: MopB_Formate-Dh-H; cd02753 637380001904 [4Fe-4S] binding site [ion binding]; other site 637380001905 molybdopterin cofactor binding site; other site 637380001906 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 637380001907 molybdopterin cofactor binding site; other site 637380001908 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 637380001909 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 637380001910 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 637380001911 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 637380001912 putative active site [active] 637380001913 catalytic site [active] 637380001914 putative metal binding site [ion binding]; other site 637380001915 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 637380001916 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 637380001917 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380001918 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 637380001919 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380001920 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637380001921 dimerization interface [polypeptide binding]; other site 637380001922 putative DNA binding site [nucleotide binding]; other site 637380001923 putative Zn2+ binding site [ion binding]; other site 637380001924 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 637380001925 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 637380001926 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 637380001927 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637380001928 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637380001929 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 637380001930 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 637380001931 active site 637380001932 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 637380001933 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 637380001934 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 637380001935 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 637380001936 active site 637380001937 Zn binding site [ion binding]; other site 637380001938 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 637380001939 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 637380001940 VanW like protein; Region: VanW; pfam04294 637380001941 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 637380001942 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 637380001943 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 637380001944 Nucleoside recognition; Region: Gate; cl00486 637380001945 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 637380001946 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 637380001947 putative metal binding site [ion binding]; other site 637380001948 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 637380001949 Domain of unknown function DUF21; Region: DUF21; pfam01595 637380001950 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 637380001951 Transporter associated domain; Region: CorC_HlyC; pfam03471 637380001952 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 637380001953 Aspartase; Region: Aspartase; cd01357 637380001954 active sites [active] 637380001955 tetramer interface [polypeptide binding]; other site 637380001956 glycolate transporter; Provisional; Region: PRK09695 637380001957 L-lactate permease; Region: Lactate_perm; cl00701 637380001958 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637380001959 putative DNA binding site [nucleotide binding]; other site 637380001960 putative Zn2+ binding site [ion binding]; other site 637380001961 Small acid-soluble spore protein H family; Region: SspH; cl06949 637380001962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 637380001963 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637380001964 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 637380001965 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 637380001966 siderophore binding site; other site 637380001967 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 637380001968 ABC-ATPase subunit interface; other site 637380001969 dimer interface [polypeptide binding]; other site 637380001970 putative PBP binding regions; other site 637380001971 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 637380001972 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 637380001973 ABC-ATPase subunit interface; other site 637380001974 dimer interface [polypeptide binding]; other site 637380001975 putative PBP binding regions; other site 637380001976 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 637380001977 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 637380001978 Walker A/P-loop; other site 637380001979 ATP binding site [chemical binding]; other site 637380001980 Q-loop/lid; other site 637380001981 ABC transporter signature motif; other site 637380001982 Walker B; other site 637380001983 D-loop; other site 637380001984 H-loop/switch region; other site 637380001985 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 637380001986 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 637380001987 substrate-cofactor binding pocket; other site 637380001988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380001989 catalytic residue [active] 637380001990 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 637380001991 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 637380001992 NAD binding site [chemical binding]; other site 637380001993 homodimer interface [polypeptide binding]; other site 637380001994 active site 637380001995 putative substrate binding site [chemical binding]; other site 637380001996 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 637380001997 nudix motif; other site 637380001998 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 637380001999 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 637380002000 metal ion-dependent adhesion site (MIDAS); other site 637380002001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380002002 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 637380002003 Walker A motif; other site 637380002004 ATP binding site [chemical binding]; other site 637380002005 Walker B motif; other site 637380002006 arginine finger; other site 637380002007 cardiolipin synthetase; Reviewed; Region: PRK12452 637380002008 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 637380002009 putative active site [active] 637380002010 catalytic site [active] 637380002011 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 637380002012 putative active site [active] 637380002013 catalytic site [active] 637380002014 PAS domain S-box; Region: sensory_box; TIGR00229 637380002015 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637380002016 putative active site [active] 637380002017 heme pocket [chemical binding]; other site 637380002018 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637380002019 metal binding site [ion binding]; metal-binding site 637380002020 active site 637380002021 I-site; other site 637380002022 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637380002023 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 637380002024 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380002025 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637380002026 DNA-binding site [nucleotide binding]; DNA binding site 637380002027 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 637380002028 UTRA domain; Region: UTRA; cl06649 637380002029 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 637380002030 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 637380002031 active site turn [active] 637380002032 phosphorylation site [posttranslational modification] 637380002033 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637380002034 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 637380002035 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 637380002036 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 637380002037 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380002038 potential frameshift: common BLAST hit: gi|227816495|ref|YP_002816504.1| spore germination protein GerKA 637380002039 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 637380002040 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 637380002041 potential frameshift: common BLAST hit: gi|118476318|ref|YP_893469.1| sensor histidine kinase domain-containing protein 637380002042 GAF domain; Region: GAF; cl00853 637380002043 Histidine kinase; Region: HisKA_3; pfam07730 637380002044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380002045 ATP binding site [chemical binding]; other site 637380002046 Mg2+ binding site [ion binding]; other site 637380002047 G-X-G motif; other site 637380002048 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637380002049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380002050 active site 637380002051 phosphorylation site [posttranslational modification] 637380002052 intermolecular recognition site; other site 637380002053 dimerization interface [polypeptide binding]; other site 637380002054 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 637380002055 DNA binding residues [nucleotide binding] 637380002056 dimerization interface [polypeptide binding]; other site 637380002057 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 637380002058 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 637380002059 putative active site [active] 637380002060 catalytic triad [active] 637380002061 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 637380002062 PA/protease domain interface [polypeptide binding]; other site 637380002063 putative integrin binding motif; other site 637380002064 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 637380002065 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 637380002066 dockerin binding interface; other site 637380002067 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 637380002068 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 637380002069 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637380002070 active site 637380002071 ATP binding site [chemical binding]; other site 637380002072 substrate binding site [chemical binding]; other site 637380002073 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 637380002074 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637380002075 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 637380002076 Walker A/P-loop; other site 637380002077 ATP binding site [chemical binding]; other site 637380002078 Q-loop/lid; other site 637380002079 ABC transporter signature motif; other site 637380002080 Walker B; other site 637380002081 D-loop; other site 637380002082 H-loop/switch region; other site 637380002083 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 637380002084 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 637380002085 substrate binding pocket [chemical binding]; other site 637380002086 membrane-bound complex binding site; other site 637380002087 hinge residues; other site 637380002088 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637380002089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380002090 dimer interface [polypeptide binding]; other site 637380002091 conserved gate region; other site 637380002092 putative PBP binding loops; other site 637380002093 ABC-ATPase subunit interface; other site 637380002094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380002095 dimer interface [polypeptide binding]; other site 637380002096 conserved gate region; other site 637380002097 putative PBP binding loops; other site 637380002098 ABC-ATPase subunit interface; other site 637380002099 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380002100 Amino acid permease; Region: AA_permease; pfam00324 637380002101 OsmC-like protein; Region: OsmC; cl00767 637380002102 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 637380002103 nucleotide binding site/active site [active] 637380002104 HIT family signature motif; other site 637380002105 catalytic residue [active] 637380002106 Predicted transcriptional regulator [Transcription]; Region: COG2378 637380002107 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380002108 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 637380002109 folate binding site [chemical binding]; other site 637380002110 NADP+ binding site [chemical binding]; other site 637380002111 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637380002112 dimerization interface [polypeptide binding]; other site 637380002113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380002114 dimer interface [polypeptide binding]; other site 637380002115 phosphorylation site [posttranslational modification] 637380002116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380002117 ATP binding site [chemical binding]; other site 637380002118 Mg2+ binding site [ion binding]; other site 637380002119 G-X-G motif; other site 637380002120 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380002121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380002122 active site 637380002123 phosphorylation site [posttranslational modification] 637380002124 intermolecular recognition site; other site 637380002125 dimerization interface [polypeptide binding]; other site 637380002126 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380002127 DNA binding site [nucleotide binding] 637380002128 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 637380002129 Sulfate transporter family; Region: Sulfate_transp; cl00967 637380002130 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 637380002131 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 637380002132 Ligand Binding Site [chemical binding]; other site 637380002133 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 637380002134 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 637380002135 peptide binding site [polypeptide binding]; other site 637380002136 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 637380002137 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 637380002138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380002139 dimer interface [polypeptide binding]; other site 637380002140 conserved gate region; other site 637380002141 putative PBP binding loops; other site 637380002142 ABC-ATPase subunit interface; other site 637380002143 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 637380002144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380002145 dimer interface [polypeptide binding]; other site 637380002146 conserved gate region; other site 637380002147 putative PBP binding loops; other site 637380002148 ABC-ATPase subunit interface; other site 637380002149 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 637380002150 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 637380002151 Walker A/P-loop; other site 637380002152 ATP binding site [chemical binding]; other site 637380002153 Q-loop/lid; other site 637380002154 ABC transporter signature motif; other site 637380002155 Walker B; other site 637380002156 D-loop; other site 637380002157 H-loop/switch region; other site 637380002158 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 637380002159 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 637380002160 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 637380002161 Walker A/P-loop; other site 637380002162 ATP binding site [chemical binding]; other site 637380002163 Q-loop/lid; other site 637380002164 ABC transporter signature motif; other site 637380002165 Walker B; other site 637380002166 D-loop; other site 637380002167 H-loop/switch region; other site 637380002168 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 637380002169 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 637380002170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380002171 putative substrate translocation pore; other site 637380002172 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380002173 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 637380002174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380002175 putative substrate translocation pore; other site 637380002176 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637380002177 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637380002178 DNA binding site [nucleotide binding] 637380002179 domain linker motif; other site 637380002180 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 637380002181 dimerization interface [polypeptide binding]; other site 637380002182 ligand binding site [chemical binding]; other site 637380002183 sodium binding site [ion binding]; other site 637380002184 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174 637380002185 substrate binding site [chemical binding]; other site 637380002186 dimer interface [polypeptide binding]; other site 637380002187 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 637380002188 ATP binding site [chemical binding]; other site 637380002189 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 637380002190 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 637380002191 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 637380002192 Walker A/P-loop; other site 637380002193 ATP binding site [chemical binding]; other site 637380002194 Q-loop/lid; other site 637380002195 ABC transporter signature motif; other site 637380002196 Walker B; other site 637380002197 D-loop; other site 637380002198 H-loop/switch region; other site 637380002199 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 637380002200 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637380002201 TM-ABC transporter signature motif; other site 637380002202 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 637380002203 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 637380002204 ligand binding site [chemical binding]; other site 637380002205 dimerization interface [polypeptide binding]; other site 637380002206 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 637380002207 active site 637380002208 intersubunit interactions; other site 637380002209 catalytic residue [active] 637380002210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 637380002211 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 637380002212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380002213 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637380002214 putative substrate translocation pore; other site 637380002215 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 637380002216 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 637380002217 putative NAD(P) binding site [chemical binding]; other site 637380002218 catalytic Zn binding site [ion binding]; other site 637380002219 Ion channel; Region: Ion_trans_2; cl11596 637380002220 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; cl03005 637380002221 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 637380002222 putative catalytic site [active] 637380002223 metal binding site A [ion binding]; metal-binding site 637380002224 phosphate binding site [ion binding]; other site 637380002225 metal binding site C [ion binding]; metal-binding site 637380002226 metal binding site B [ion binding]; metal-binding site 637380002227 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 637380002228 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 637380002229 dimer interface [polypeptide binding]; other site 637380002230 active site 637380002231 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637380002232 substrate binding site [chemical binding]; other site 637380002233 catalytic residue [active] 637380002234 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 637380002235 FAD binding domain; Region: FAD_binding_4; pfam01565 637380002236 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 637380002237 VanZ like family; Region: VanZ; cl01971 637380002238 RDD family; Region: RDD; cl00746 637380002239 Bacitracin resistance protein BacA; Region: BacA; cl00858 637380002240 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 637380002241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 637380002242 3D domain; Region: 3D; cl01439 637380002243 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380002244 non-specific DNA binding site [nucleotide binding]; other site 637380002245 salt bridge; other site 637380002246 sequence-specific DNA binding site [nucleotide binding]; other site 637380002247 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 637380002248 active site 637380002249 catalytic site [active] 637380002250 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 637380002251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380002252 putative substrate translocation pore; other site 637380002253 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 637380002254 Archaeal flagella protein; Region: Arch_fla_DE; cl01322 637380002255 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 637380002256 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 637380002257 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 637380002258 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380002259 Amino acid permease; Region: AA_permease; pfam00324 637380002260 Sulfate transporter family; Region: Sulfate_transp; cl00967 637380002261 Permease family; Region: Xan_ur_permease; pfam00860 637380002262 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380002263 non-specific DNA binding site [nucleotide binding]; other site 637380002264 salt bridge; other site 637380002265 sequence-specific DNA binding site [nucleotide binding]; other site 637380002266 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380002267 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 637380002268 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 637380002269 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 637380002270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380002271 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380002272 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 637380002273 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 637380002274 Subunit I/III interface [polypeptide binding]; other site 637380002275 Subunit III/IV interface [polypeptide binding]; other site 637380002276 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 637380002277 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 637380002278 D-pathway; other site 637380002279 Putative ubiquinol binding site [chemical binding]; other site 637380002280 Low-spin heme (heme b) binding site [chemical binding]; other site 637380002281 Putative water exit pathway; other site 637380002282 Binuclear center (heme o3/CuB) [ion binding]; other site 637380002283 K-pathway; other site 637380002284 Putative proton exit pathway; other site 637380002285 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 637380002286 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380002287 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 637380002288 putative active site [active] 637380002289 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 637380002290 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 637380002291 metal binding site [ion binding]; metal-binding site 637380002292 dimer interface [polypeptide binding]; other site 637380002293 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 637380002294 Sodium:solute symporter family; Region: SSF; cl00456 637380002295 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 637380002296 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 637380002297 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380002298 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 637380002299 FeoA domain; Region: FeoA; cl00838 637380002300 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380002301 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 637380002302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380002303 dimer interface [polypeptide binding]; other site 637380002304 conserved gate region; other site 637380002305 putative PBP binding loops; other site 637380002306 ABC-ATPase subunit interface; other site 637380002307 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 637380002308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380002309 dimer interface [polypeptide binding]; other site 637380002310 conserved gate region; other site 637380002311 putative PBP binding loops; other site 637380002312 ABC-ATPase subunit interface; other site 637380002313 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 637380002314 FOG: CBS domain [General function prediction only]; Region: COG0517 637380002315 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_9; cd04622 637380002316 Bacterial SH3 domain; Region: SH3_3; cl02551 637380002317 Bacterial SH3 domain; Region: SH3_3; cl02551 637380002318 Bacterial SH3 domain; Region: SH3_3; cl02551 637380002319 Peptidase family M23; Region: Peptidase_M23; pfam01551 637380002320 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 637380002321 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 637380002322 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 637380002323 Walker A/P-loop; other site 637380002324 ATP binding site [chemical binding]; other site 637380002325 Q-loop/lid; other site 637380002326 ABC transporter signature motif; other site 637380002327 Walker B; other site 637380002328 D-loop; other site 637380002329 H-loop/switch region; other site 637380002330 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 637380002331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 637380002332 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 637380002333 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380002334 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 637380002335 thiamine phosphate binding site [chemical binding]; other site 637380002336 active site 637380002337 pyrophosphate binding site [ion binding]; other site 637380002338 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 637380002339 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 637380002340 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 637380002341 thiS-thiF/thiG interaction site; other site 637380002342 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 637380002343 ThiS interaction site; other site 637380002344 putative active site [active] 637380002345 tetramer interface [polypeptide binding]; other site 637380002346 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 637380002347 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 637380002348 ATP binding site [chemical binding]; other site 637380002349 substrate interface [chemical binding]; other site 637380002350 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 637380002351 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 637380002352 dimer interface [polypeptide binding]; other site 637380002353 substrate binding site [chemical binding]; other site 637380002354 ATP binding site [chemical binding]; other site 637380002355 BACI_c07660; ydaO/yuaA leader, RF00379 637380002356 BACI_c07680; ydaO/yuaA leader, RF00379 637380002357 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; cl00903 637380002358 Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814 637380002359 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 637380002360 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637380002361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637380002362 K+-transporting ATPase, c chain; Region: KdpC; cl00944 637380002363 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 637380002364 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 637380002365 Ligand Binding Site [chemical binding]; other site 637380002366 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 637380002367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380002368 putative substrate translocation pore; other site 637380002369 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380002370 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 637380002371 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 637380002372 active site 637380002373 nucleophile elbow; other site 637380002374 FtsX-like permease family; Region: FtsX; pfam02687 637380002375 FtsX-like permease family; Region: FtsX; pfam02687 637380002376 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637380002377 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637380002378 Walker A/P-loop; other site 637380002379 ATP binding site [chemical binding]; other site 637380002380 Q-loop/lid; other site 637380002381 ABC transporter signature motif; other site 637380002382 Walker B; other site 637380002383 D-loop; other site 637380002384 H-loop/switch region; other site 637380002385 Sulfate transporter family; Region: Sulfate_transp; cl00967 637380002386 Permease family; Region: Xan_ur_permease; pfam00860 637380002387 short chain dehydrogenase; Provisional; Region: PRK06701 637380002388 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 637380002389 NAD binding site [chemical binding]; other site 637380002390 metal binding site [ion binding]; metal-binding site 637380002391 active site 637380002392 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 637380002393 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 637380002394 putative substrate binding site [chemical binding]; other site 637380002395 putative ATP binding site [chemical binding]; other site 637380002396 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 637380002397 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 637380002398 substrate binding [chemical binding]; other site 637380002399 active site 637380002400 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 637380002401 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 637380002402 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 637380002403 active site turn [active] 637380002404 phosphorylation site [posttranslational modification] 637380002405 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637380002406 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637380002407 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637380002408 DNA binding site [nucleotide binding] 637380002409 domain linker motif; other site 637380002410 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 637380002411 dimerization interface [polypeptide binding]; other site 637380002412 ligand binding site [chemical binding]; other site 637380002413 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 637380002414 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 637380002415 catalytic residues [active] 637380002416 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 637380002417 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380002418 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 637380002419 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 637380002420 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a beta-...; Region: Arsenite_oxidase; cd02135 637380002421 putative FMN binding site [chemical binding]; other site 637380002422 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 637380002423 SpoVR like protein; Region: SpoVR; pfam04293 637380002424 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 637380002425 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 637380002426 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380002427 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 637380002428 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar rhodanese-...; Region: RHOD_Pyr_redox; cd01524 637380002429 active site residue [active] 637380002430 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 637380002431 putative homotetramer interface [polypeptide binding]; other site 637380002432 putative homodimer interface [polypeptide binding]; other site 637380002433 putative metal binding site [ion binding]; other site 637380002434 putative homodimer-homodimer interface [polypeptide binding]; other site 637380002435 putative allosteric switch controlling residues; other site 637380002436 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 637380002437 CPxP motif; other site 637380002438 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 637380002439 active site residue [active] 637380002440 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 637380002441 active site residue [active] 637380002442 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380002443 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 637380002444 CPxP motif; other site 637380002445 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 637380002446 CPxP motif; other site 637380002447 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 637380002448 active site residue [active] 637380002449 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 637380002450 active site residue [active] 637380002451 DsrE/DsrF-like family; Region: DrsE; cl00672 637380002452 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 637380002453 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 637380002454 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 637380002455 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 637380002456 NADP binding site [chemical binding]; other site 637380002457 dimer interface [polypeptide binding]; other site 637380002458 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 637380002459 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 637380002460 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 637380002461 PhoU domain; Region: PhoU; pfam01895 637380002462 PhoU domain; Region: PhoU; pfam01895 637380002463 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637380002464 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 637380002465 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 637380002466 Rhodopirellula transposase; Region: DDE_Tnp_ISAZ013; pfam07592 637380002467 Integrase core domain; Region: rve; cl01316 637380002468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380002469 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637380002470 putative substrate translocation pore; other site 637380002471 Uncharacterized conserved protein [Function unknown]; Region: COG3589 637380002472 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 637380002473 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 637380002474 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380002475 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380002476 PRD domain; Region: PRD; pfam00874 637380002477 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 637380002478 P-loop; other site 637380002479 active site 637380002480 phosphorylation site [posttranslational modification] 637380002481 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637380002482 active site 637380002483 phosphorylation site [posttranslational modification] 637380002484 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 637380002485 active site 637380002486 methionine cluster; other site 637380002487 phosphorylation site [posttranslational modification] 637380002488 metal binding site [ion binding]; metal-binding site 637380002489 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 637380002490 active site 637380002491 P-loop; other site 637380002492 phosphorylation site [posttranslational modification] 637380002493 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637380002494 Uncharacterized conserved protein [Function unknown]; Region: COG3589 637380002495 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 637380002496 Bacterial SH3 domain; Region: SH3_3; cl02551 637380002497 Bacterial SH3 domain; Region: SH3_3; cl02551 637380002498 3D domain; Region: 3D; cl01439 637380002499 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380002500 non-specific DNA binding site [nucleotide binding]; other site 637380002501 salt bridge; other site 637380002502 sequence-specific DNA binding site [nucleotide binding]; other site 637380002503 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 637380002504 Holin family; Region: Phage_holin_4; cl01989 637380002505 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required...; Region: GH25_PlyB-like; cd06523 637380002506 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 637380002507 active site 637380002508 NlpC/P60 family; Region: NLPC_P60; cl11438 637380002509 3D domain; Region: 3D; cl01439 637380002510 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 637380002511 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637380002512 FtsX-like permease family; Region: FtsX; pfam02687 637380002513 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637380002514 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637380002515 Walker A/P-loop; other site 637380002516 ATP binding site [chemical binding]; other site 637380002517 Q-loop/lid; other site 637380002518 ABC transporter signature motif; other site 637380002519 Walker B; other site 637380002520 D-loop; other site 637380002521 H-loop/switch region; other site 637380002522 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 637380002523 Predicted integral membrane protein [Function unknown]; Region: COG5522; cl02331 637380002524 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 637380002525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 637380002526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380002527 dimer interface [polypeptide binding]; other site 637380002528 conserved gate region; other site 637380002529 ABC-ATPase subunit interface; other site 637380002530 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 637380002531 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 637380002532 dimanganese center [ion binding]; other site 637380002533 CotJB protein; Region: CotJB; pfam12652 637380002534 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 637380002535 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 637380002536 active site 637380002537 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 637380002538 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 637380002539 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 637380002540 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 637380002541 putative DNA binding site [nucleotide binding]; other site 637380002542 putative homodimer interface [polypeptide binding]; other site 637380002543 BACI_c08470; yybP-ykoY leader, RF00080 637380002544 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 637380002545 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 637380002546 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 637380002547 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637380002548 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 637380002549 active site 637380002550 metal binding site [ion binding]; metal-binding site 637380002551 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637380002552 Interdomain contacts; other site 637380002553 Cytokine receptor motif; other site 637380002554 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 637380002555 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380002556 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 637380002557 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 637380002558 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 637380002559 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 637380002560 putative active site [active] 637380002561 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 637380002562 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 637380002563 putative active site [active] 637380002564 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 637380002565 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 637380002566 active site turn [active] 637380002567 phosphorylation site [posttranslational modification] 637380002568 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637380002569 Uncharacterized conserved protein [Function unknown]; Region: COG3589 637380002570 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 637380002571 DoxX; Region: DoxX; cl00976 637380002572 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 637380002573 hypothetical protein; Provisional; Region: PRK06770 637380002574 EamA-like transporter family; Region: EamA; cl01037 637380002575 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 637380002576 EamA-like transporter family; Region: EamA; cl01037 637380002577 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380002578 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 637380002579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380002580 Coenzyme A binding pocket [chemical binding]; other site 637380002581 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 637380002582 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 637380002583 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380002584 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380002585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380002586 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637380002587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380002588 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380002589 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380002590 Transcriptional regulators [Transcription]; Region: MarR; COG1846 637380002591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380002592 hypothetical protein; Provisional; Region: PRK06847 637380002593 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380002594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380002595 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 637380002596 putative substrate translocation pore; other site 637380002597 Transposase domain (DUF772); Region: DUF772; cl12084 637380002598 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380002599 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 637380002600 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380002601 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 637380002602 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380002603 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380002604 Cytochrome P450; Region: p450; cl12078 637380002605 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 637380002606 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380002607 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 637380002608 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 637380002609 putative NAD(P) binding site [chemical binding]; other site 637380002610 catalytic Zn binding site [ion binding]; other site 637380002611 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 637380002612 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 637380002613 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 637380002614 proposed catalytic triad [active] 637380002615 conserved cys residue [active] 637380002616 hydroperoxidase II; Provisional; Region: katE; PRK11249 637380002617 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 637380002618 tetramer interface [polypeptide binding]; other site 637380002619 heme binding pocket [chemical binding]; other site 637380002620 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 637380002621 domain interactions; other site 637380002622 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 637380002623 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380002624 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 637380002625 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 637380002626 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 637380002627 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 637380002628 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 637380002629 tetrameric interface [polypeptide binding]; other site 637380002630 activator binding site; other site 637380002631 NADP binding site [chemical binding]; other site 637380002632 substrate binding site [chemical binding]; other site 637380002633 catalytic residues [active] 637380002634 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637380002635 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 637380002636 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380002637 Walker A/P-loop; other site 637380002638 ATP binding site [chemical binding]; other site 637380002639 Q-loop/lid; other site 637380002640 ABC transporter signature motif; other site 637380002641 Walker B; other site 637380002642 D-loop; other site 637380002643 H-loop/switch region; other site 637380002644 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637380002645 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 637380002646 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 637380002647 Walker A/P-loop; other site 637380002648 ATP binding site [chemical binding]; other site 637380002649 Q-loop/lid; other site 637380002650 ABC transporter signature motif; other site 637380002651 Walker B; other site 637380002652 D-loop; other site 637380002653 H-loop/switch region; other site 637380002654 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637380002655 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 637380002656 substrate binding pocket [chemical binding]; other site 637380002657 membrane-bound complex binding site; other site 637380002658 hinge residues; other site 637380002659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380002660 dimer interface [polypeptide binding]; other site 637380002661 conserved gate region; other site 637380002662 putative PBP binding loops; other site 637380002663 ABC-ATPase subunit interface; other site 637380002664 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637380002665 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 637380002666 Walker A/P-loop; other site 637380002667 ATP binding site [chemical binding]; other site 637380002668 Q-loop/lid; other site 637380002669 ABC transporter signature motif; other site 637380002670 Walker B; other site 637380002671 D-loop; other site 637380002672 H-loop/switch region; other site 637380002673 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 637380002674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 637380002675 Protein of unknown function (DUF964); Region: DUF964; cl01483 637380002676 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 637380002677 acetolactate synthase; Reviewed; Region: PRK08617 637380002678 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 637380002679 PYR/PP interface [polypeptide binding]; other site 637380002680 dimer interface [polypeptide binding]; other site 637380002681 TPP binding site [chemical binding]; other site 637380002682 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637380002683 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 637380002684 TPP-binding site [chemical binding]; other site 637380002685 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 637380002686 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 637380002687 active site 637380002688 DNA binding site [nucleotide binding] 637380002689 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637380002690 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637380002691 active site 637380002692 motif I; other site 637380002693 motif II; other site 637380002694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637380002695 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 637380002696 amidase catalytic site [active] 637380002697 Zn binding residues [ion binding]; other site 637380002698 substrate binding site [chemical binding]; other site 637380002699 S-layer homology domain; Region: SLH; pfam00395 637380002700 S-layer homology domain; Region: SLH; pfam00395 637380002701 S-layer homology domain; Region: SLH; pfam00395 637380002702 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 637380002703 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 637380002704 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 637380002705 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 637380002706 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 637380002707 Sulfate transporter family; Region: Sulfate_transp; cl00967 637380002708 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 637380002709 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 637380002710 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 637380002711 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 637380002712 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637380002713 nucleotide binding region [chemical binding]; other site 637380002714 ATP-binding site [chemical binding]; other site 637380002715 stage V sporulation protein B; Region: spore_V_B; TIGR02900 637380002716 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 637380002717 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 637380002718 S-layer homology domain; Region: SLH; pfam00395 637380002719 S-layer homology domain; Region: SLH; pfam00395 637380002720 S-layer homology domain; Region: SLH; pfam00395 637380002721 S-layer homology domain; Region: SLH; pfam00395 637380002722 S-layer homology domain; Region: SLH; pfam00395 637380002723 S-layer homology domain; Region: SLH; pfam00395 637380002724 MBOAT family; Region: MBOAT; cl00738 637380002725 enoyl-CoA hydratase; Provisional; Region: PRK07659 637380002726 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 637380002727 substrate binding site [chemical binding]; other site 637380002728 oxyanion hole (OAH) forming residues; other site 637380002729 trimer interface [polypeptide binding]; other site 637380002730 potential frameshift: common BLAST hit: gi|118478839|ref|YP_895990.1| IS605 family transposase 637380002731 N-terminal domain; Region: tspaseT_teng_N; TIGR01765 637380002732 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 637380002733 Uncharacterized conserved protein [Function unknown]; Region: COG4997 637380002734 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 637380002735 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 637380002736 putative oligomer interface [polypeptide binding]; other site 637380002737 putative active site [active] 637380002738 metal binding site [ion binding]; metal-binding site 637380002739 S-layer homology domain; Region: SLH; pfam00395 637380002740 S-layer homology domain; Region: SLH; pfam00395 637380002741 S-layer homology domain; Region: SLH; pfam00395 637380002742 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 637380002743 active site 637380002744 metal binding site [ion binding]; metal-binding site 637380002745 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 637380002746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380002747 proline racemase; Provisional; Region: PRK13969 637380002748 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 637380002749 ornithine cyclodeaminase; Validated; Region: PRK08618 637380002750 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 637380002751 NAD(P) binding site [chemical binding]; other site 637380002752 Yip1 domain; Region: Yip1; cl12048 637380002753 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 637380002754 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 637380002755 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 637380002756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380002757 dimer interface [polypeptide binding]; other site 637380002758 conserved gate region; other site 637380002759 putative PBP binding loops; other site 637380002760 ABC-ATPase subunit interface; other site 637380002761 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 637380002762 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 637380002763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380002764 dimer interface [polypeptide binding]; other site 637380002765 conserved gate region; other site 637380002766 putative PBP binding loops; other site 637380002767 ABC-ATPase subunit interface; other site 637380002768 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 637380002769 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 637380002770 Walker A/P-loop; other site 637380002771 ATP binding site [chemical binding]; other site 637380002772 Q-loop/lid; other site 637380002773 ABC transporter signature motif; other site 637380002774 Walker B; other site 637380002775 D-loop; other site 637380002776 H-loop/switch region; other site 637380002777 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 637380002778 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 637380002779 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 637380002780 Walker A/P-loop; other site 637380002781 ATP binding site [chemical binding]; other site 637380002782 Q-loop/lid; other site 637380002783 ABC transporter signature motif; other site 637380002784 Walker B; other site 637380002785 D-loop; other site 637380002786 H-loop/switch region; other site 637380002787 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 637380002788 Vitamin-D-receptor interacting Mediator subunit 4; Region: Med4; pfam10018 637380002789 Transposase domain (DUF772); Region: DUF772; cl12084 637380002790 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 637380002791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380002792 putative substrate translocation pore; other site 637380002793 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 637380002794 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 637380002795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380002796 ATP binding site [chemical binding]; other site 637380002797 Mg2+ binding site [ion binding]; other site 637380002798 G-X-G motif; other site 637380002799 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 637380002800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380002801 active site 637380002802 phosphorylation site [posttranslational modification] 637380002803 intermolecular recognition site; other site 637380002804 dimerization interface [polypeptide binding]; other site 637380002805 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380002806 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 637380002807 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380002808 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 637380002809 Protein of unknown function (DUF524); Region: DUF524; pfam04411 637380002810 potential frameshift: common BLAST hit: gi|227816207|ref|YP_002816216.1| transcriptional regulator, MerR family 637380002811 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 637380002812 DNA binding residues [nucleotide binding] 637380002813 dimer interface [polypeptide binding]; other site 637380002814 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 637380002815 replicative DNA helicase; Provisional; Region: PRK06749 637380002816 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 637380002817 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 637380002818 Walker A motif; other site 637380002819 ATP binding site [chemical binding]; other site 637380002820 Walker B motif; other site 637380002821 DNA binding loops [nucleotide binding] 637380002822 Domain of Unknown Function with PDB structure; Region: DUF3862; pfam12978 637380002823 Predicted transcriptional regulators [Transcription]; Region: COG1378 637380002824 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380002825 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 637380002826 C-terminal domain interface [polypeptide binding]; other site 637380002827 sugar binding site [chemical binding]; other site 637380002828 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 637380002829 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 637380002830 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380002831 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380002832 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 637380002833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380002834 putative substrate translocation pore; other site 637380002835 Predicted permease; Region: DUF318; cl00487 637380002836 Predicted permease; Region: DUF318; cl00487 637380002837 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380002838 Chlorophyllase enzyme; Region: Chlorophyllase2; cl14889 637380002839 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 637380002840 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 637380002841 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 637380002842 CGNR zinc finger; Region: zf-CGNR; pfam11706 637380002843 HPP family; Region: HPP; pfam04982 637380002844 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 637380002845 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 637380002846 putative NAD(P) binding site [chemical binding]; other site 637380002847 active site 637380002848 putative substrate binding site [chemical binding]; other site 637380002849 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637380002850 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380002851 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380002852 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380002853 Transposase domain (DUF772); Region: DUF772; cl12084 637380002854 Transcriptional regulators [Transcription]; Region: MarR; COG1846 637380002855 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380002856 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 637380002857 ATP synthase I chain; Region: ATP_synt_I; cl09170 637380002858 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637380002859 active site 637380002860 ATP binding site [chemical binding]; other site 637380002861 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637380002862 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 637380002863 VanZ like family; Region: VanZ; cl01971 637380002864 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 637380002865 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 637380002866 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 637380002867 dihydroxyacetone kinase; Provisional; Region: PRK14479 637380002868 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 637380002869 DAK2 domain; Region: Dak2; cl03685 637380002870 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 637380002871 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637380002872 Zn2+ binding site [ion binding]; other site 637380002873 Mg2+ binding site [ion binding]; other site 637380002874 S-layer homology domain; Region: SLH; pfam00395 637380002875 S-layer homology domain; Region: SLH; pfam00395 637380002876 S-layer homology domain; Region: SLH; pfam00395 637380002877 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 637380002878 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380002879 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 637380002880 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 637380002881 Heat induced stress protein YflT; Region: YflT; pfam11181 637380002882 CsbD-like; Region: CsbD; cl01272 637380002883 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 637380002884 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 637380002885 anti sigma factor interaction site; other site 637380002886 regulatory phosphorylation site [posttranslational modification]; other site 637380002887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380002888 ATP binding site [chemical binding]; other site 637380002889 Mg2+ binding site [ion binding]; other site 637380002890 G-X-G motif; other site 637380002891 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 637380002892 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637380002893 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 637380002894 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 637380002895 DNA binding residues [nucleotide binding] 637380002896 Ferritin-like domain; Region: Ferritin; pfam00210 637380002897 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 637380002898 dinuclear metal binding motif [ion binding]; other site 637380002899 Response regulator receiver domain; Region: Response_reg; pfam00072 637380002900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380002901 active site 637380002902 phosphorylation site [posttranslational modification] 637380002903 intermolecular recognition site; other site 637380002904 dimerization interface [polypeptide binding]; other site 637380002905 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 637380002906 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 637380002907 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 637380002908 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 637380002909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380002910 CHASE3 domain; Region: CHASE3; cl05000 637380002911 GAF domain; Region: GAF; cl00853 637380002912 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380002913 dimer interface [polypeptide binding]; other site 637380002914 phosphorylation site [posttranslational modification] 637380002915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380002916 ATP binding site [chemical binding]; other site 637380002917 Mg2+ binding site [ion binding]; other site 637380002918 G-X-G motif; other site 637380002919 Response regulator receiver domain; Region: Response_reg; pfam00072 637380002920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380002921 active site 637380002922 phosphorylation site [posttranslational modification] 637380002923 intermolecular recognition site; other site 637380002924 dimerization interface [polypeptide binding]; other site 637380002925 Domain of unknown function (DUF74); Region: DUF74; cl00426 637380002926 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380002927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380002928 active site 637380002929 phosphorylation site [posttranslational modification] 637380002930 intermolecular recognition site; other site 637380002931 dimerization interface [polypeptide binding]; other site 637380002932 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380002933 DNA binding site [nucleotide binding] 637380002934 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 637380002935 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380002936 dimer interface [polypeptide binding]; other site 637380002937 phosphorylation site [posttranslational modification] 637380002938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380002939 ATP binding site [chemical binding]; other site 637380002940 Mg2+ binding site [ion binding]; other site 637380002941 G-X-G motif; other site 637380002942 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637380002943 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 637380002944 Walker A/P-loop; other site 637380002945 ATP binding site [chemical binding]; other site 637380002946 Q-loop/lid; other site 637380002947 ABC transporter signature motif; other site 637380002948 Walker B; other site 637380002949 D-loop; other site 637380002950 H-loop/switch region; other site 637380002951 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637380002952 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637380002953 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 637380002954 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 637380002955 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 637380002956 NADP binding site [chemical binding]; other site 637380002957 dimer interface [polypeptide binding]; other site 637380002958 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 637380002959 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637380002960 active site 637380002961 metal binding site [ion binding]; metal-binding site 637380002962 DNA binding site [nucleotide binding] 637380002963 Uncharacterized conserved protein [Function unknown]; Region: COG4717 637380002964 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 637380002965 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 637380002966 Probable transposase; Region: OrfB_IS605; pfam01385 637380002967 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 637380002968 Uncharacterized conserved protein [Function unknown]; Region: COG4717 637380002969 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380002970 Q-loop/lid; other site 637380002971 ABC transporter signature motif; other site 637380002972 Walker B; other site 637380002973 D-loop; other site 637380002974 H-loop/switch region; other site 637380002975 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 637380002976 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 637380002977 generic binding surface II; other site 637380002978 generic binding surface I; other site 637380002979 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637380002980 Zn2+ binding site [ion binding]; other site 637380002981 Mg2+ binding site [ion binding]; other site 637380002982 Proteins of 100 residues with WXG; Region: WXG100; cl02005 637380002983 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 637380002984 Zn binding site [ion binding]; other site 637380002985 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 637380002986 Zn binding site [ion binding]; other site 637380002987 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 637380002988 Zn binding site [ion binding]; other site 637380002989 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 637380002990 Zn binding site [ion binding]; other site 637380002991 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637380002992 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380002993 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 637380002994 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 637380002995 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380002996 non-specific DNA binding site [nucleotide binding]; other site 637380002997 salt bridge; other site 637380002998 sequence-specific DNA binding site [nucleotide binding]; other site 637380002999 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 637380003000 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333 637380003001 amphipathic channel; other site 637380003002 Asn-Pro-Ala signature motifs; other site 637380003003 glycerol kinase; Provisional; Region: glpK; PRK00047 637380003004 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 637380003005 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 637380003006 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 637380003007 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 637380003008 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 637380003009 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637380003010 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 637380003011 DNA binding residues [nucleotide binding] 637380003012 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380003013 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 637380003014 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380003015 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 637380003016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380003017 putative substrate translocation pore; other site 637380003018 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 637380003019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380003020 putative substrate translocation pore; other site 637380003021 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 637380003022 UvrD/REP helicase; Region: UvrD-helicase; cl14126 637380003023 UvrD/REP helicase; Region: UvrD-helicase; cl14126 637380003024 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 637380003025 PPIC-type PPIASE domain; Region: Rotamase; cl08278 637380003026 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 637380003027 transcriptional regulator Hpr; Provisional; Region: PRK13777 637380003028 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380003029 YtxH-like protein; Region: YtxH; cl02079 637380003030 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life...; Region: HINT_subgroup; cd01277 637380003031 HIT family signature motif; other site 637380003032 catalytic residue [active] 637380003033 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 637380003034 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 637380003035 Walker A/P-loop; other site 637380003036 ATP binding site [chemical binding]; other site 637380003037 Q-loop/lid; other site 637380003038 ABC transporter signature motif; other site 637380003039 Walker B; other site 637380003040 D-loop; other site 637380003041 H-loop/switch region; other site 637380003042 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 637380003043 EcsC protein family; Region: EcsC; pfam12787 637380003044 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 637380003045 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 637380003046 active site flap/lid [active] 637380003047 nucleophilic elbow; other site 637380003048 catalytic triad [active] 637380003049 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380003050 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380003051 Bacterial membrane flanked domain; Region: DUF304; cl01348 637380003052 Predicted membrane protein [Function unknown]; Region: COG3428 637380003053 Bacterial membrane flanked domain; Region: DUF304; cl01348 637380003054 Bacterial membrane flanked domain; Region: DUF304; cl01348 637380003055 Bacterial membrane flanked domain; Region: DUF304; cl01348 637380003056 S-layer homology domain; Region: SLH; pfam00395 637380003057 S-layer homology domain; Region: SLH; pfam00395 637380003058 S-layer homology domain; Region: SLH; pfam00395 637380003059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 637380003060 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 637380003061 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 637380003062 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 637380003063 DNA binding residues [nucleotide binding] 637380003064 drug binding residues [chemical binding]; other site 637380003065 dimer interface [polypeptide binding]; other site 637380003066 Bacterial membrane flanked domain; Region: DUF304; cl01348 637380003067 Bacterial membrane flanked domain; Region: DUF304; cl01348 637380003068 Bacterial membrane flanked domain; Region: DUF304; cl01348 637380003069 Bacterial membrane flanked domain; Region: DUF304; cl01348 637380003070 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 637380003071 Transglycosylase; Region: Transgly; cl07896 637380003072 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 637380003073 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 637380003074 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 637380003075 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 637380003076 substrate binding site [chemical binding]; other site 637380003077 active site 637380003078 ferrochelatase; Provisional; Region: PRK12435 637380003079 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 637380003080 C-terminal domain interface [polypeptide binding]; other site 637380003081 active site 637380003082 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 637380003083 active site 637380003084 N-terminal domain interface [polypeptide binding]; other site 637380003085 protoporphyrinogen oxidase; Region: proto_IX_ox; TIGR00562 637380003086 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380003087 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; cl01543 637380003088 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 637380003089 generic binding surface II; other site 637380003090 generic binding surface I; other site 637380003091 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 637380003092 putative active site [active] 637380003093 putative catalytic site [active] 637380003094 putative Mg binding site IVb [ion binding]; other site 637380003095 putative phosphate binding site [ion binding]; other site 637380003096 putative DNA binding site [nucleotide binding]; other site 637380003097 putative Mg binding site IVa [ion binding]; other site 637380003098 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380003099 Predicted membrane protein [Function unknown]; Region: COG1511 637380003100 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 637380003101 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 637380003102 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 637380003103 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637380003104 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 637380003105 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380003106 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380003107 Coenzyme A binding pocket [chemical binding]; other site 637380003108 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637380003109 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637380003110 DNA binding site [nucleotide binding] 637380003111 domain linker motif; other site 637380003112 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 637380003113 putative dimerization interface [polypeptide binding]; other site 637380003114 putative ligand binding site [chemical binding]; other site 637380003115 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380003116 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 637380003117 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 637380003118 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 637380003119 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 637380003120 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 637380003121 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 637380003122 heme-binding site [chemical binding]; other site 637380003123 S-layer homology domain; Region: SLH; pfam00395 637380003124 S-layer homology domain; Region: SLH; pfam00395 637380003125 S-layer homology domain; Region: SLH; pfam00395 637380003126 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 637380003127 RHS Repeat; Region: RHS_repeat; cl11982 637380003128 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 637380003129 RHS protein; Region: RHS; pfam03527 637380003130 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 637380003131 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 637380003132 RHS Repeat; Region: RHS_repeat; cl11982 637380003133 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 637380003134 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 637380003135 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 637380003136 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380003137 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 637380003138 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380003139 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380003140 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 637380003141 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637380003142 putative active site [active] 637380003143 putative metal binding site [ion binding]; other site 637380003144 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 637380003145 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 637380003146 RNA polymerase sigma factor; Provisional; Region: PRK12541 637380003147 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637380003148 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 637380003149 DNA binding residues [nucleotide binding] 637380003150 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637380003151 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 637380003152 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 637380003153 active site 637380003154 metal binding site [ion binding]; metal-binding site 637380003155 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380003156 dimer interface [polypeptide binding]; other site 637380003157 phosphorylation site [posttranslational modification] 637380003158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380003159 ATP binding site [chemical binding]; other site 637380003160 Mg2+ binding site [ion binding]; other site 637380003161 G-X-G motif; other site 637380003162 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380003163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380003164 active site 637380003165 phosphorylation site [posttranslational modification] 637380003166 intermolecular recognition site; other site 637380003167 dimerization interface [polypeptide binding]; other site 637380003168 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380003169 DNA binding site [nucleotide binding] 637380003170 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 637380003171 Peptidase family M48; Region: Peptidase_M48; cl12018 637380003172 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 637380003173 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 637380003174 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637380003175 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 637380003176 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 637380003177 EamA-like transporter family; Region: EamA; cl01037 637380003178 EamA-like transporter family; Region: EamA; cl01037 637380003179 S-layer homology domain; Region: SLH; pfam00395 637380003180 S-layer homology domain; Region: SLH; pfam00395 637380003181 S-layer homology domain; Region: SLH; pfam00395 637380003182 S-layer homology domain; Region: SLH; pfam00395 637380003183 S-layer homology domain; Region: SLH; pfam00395 637380003184 S-layer homology domain; Region: SLH; pfam00395 637380003185 malate synthase A; Region: malate_syn_A; TIGR01344 637380003186 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 637380003187 active site 637380003188 isocitrate lyase; Provisional; Region: PRK06498 637380003189 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 637380003190 tetramer interface [polypeptide binding]; other site 637380003191 active site 637380003192 Mg2+/Mn2+ binding site [ion binding]; other site 637380003193 Phosphotransferase enzyme family; Region: APH; pfam01636 637380003194 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 637380003195 active site 637380003196 substrate binding site [chemical binding]; other site 637380003197 ATP binding site [chemical binding]; other site 637380003198 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 637380003199 DNA-binding site [nucleotide binding]; DNA binding site 637380003200 RNA-binding motif; other site 637380003201 ComK protein; Region: ComK; cl11560 637380003202 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 637380003203 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 637380003204 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637380003205 Catalytic site [active] 637380003206 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637380003207 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 637380003208 UvrD/REP helicase; Region: UvrD-helicase; cl14126 637380003209 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 637380003210 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 637380003211 helicase-exonuclease AddAB, AddA subunit; Region: addA_Gpos; TIGR02785 637380003212 UvrD/REP helicase; Region: UvrD-helicase; cl14126 637380003213 UvrD/REP helicase; Region: UvrD-helicase; cl14126 637380003214 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 637380003215 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 637380003216 Transposase domain (DUF772); Region: DUF772; cl12084 637380003217 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 637380003218 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 637380003219 Spore germination protein GerPC; Region: GerPC; pfam10737 637380003220 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 637380003221 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 637380003222 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 637380003223 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 637380003224 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 637380003225 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 637380003226 inhibitor-cofactor binding pocket; inhibition site 637380003227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380003228 catalytic residue [active] 637380003229 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 637380003230 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 637380003231 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 637380003232 active site 637380003233 dimer interface [polypeptide binding]; other site 637380003234 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637380003235 Transposase [DNA replication, recombination, and repair]; Region: COG5421 637380003236 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 637380003237 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 637380003238 Ligand Binding Site [chemical binding]; other site 637380003239 Molecular Tunnel; other site 637380003240 ferrochelatase; Provisional; Region: PRK12435 637380003241 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 637380003242 C-terminal domain interface [polypeptide binding]; other site 637380003243 active site 637380003244 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 637380003245 active site 637380003246 N-terminal domain interface [polypeptide binding]; other site 637380003247 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 637380003248 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 637380003249 tetramer interface [polypeptide binding]; other site 637380003250 heme binding pocket [chemical binding]; other site 637380003251 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 637380003252 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 637380003253 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 637380003254 maltodextrin glucosidase; Provisional; Region: PRK10785 637380003255 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 637380003256 Protein of unknown function (DUF520); Region: DUF520; cl00723 637380003257 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 637380003258 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 637380003259 PPIC-type PPIASE domain; Region: Rotamase; cl08278 637380003260 Uncharacterized conserved protein [Function unknown]; Region: COG1284 637380003261 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637380003262 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637380003263 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 637380003264 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 637380003265 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637380003266 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637380003267 active site 637380003268 motif I; other site 637380003269 motif II; other site 637380003270 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637380003271 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 637380003272 Clp amino terminal domain; Region: Clp_N; pfam02861 637380003273 Clp amino terminal domain; Region: Clp_N; pfam02861 637380003274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380003275 Walker A motif; other site 637380003276 ATP binding site [chemical binding]; other site 637380003277 Walker B motif; other site 637380003278 arginine finger; other site 637380003279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380003280 Walker A motif; other site 637380003281 ATP binding site [chemical binding]; other site 637380003282 Walker B motif; other site 637380003283 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 637380003284 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 637380003285 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 637380003286 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 637380003287 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 637380003288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380003289 NAD(P) binding site [chemical binding]; other site 637380003290 active site 637380003291 ComZ; Region: ComZ; pfam10815 637380003292 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 637380003293 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 637380003294 dimer interface [polypeptide binding]; other site 637380003295 active site 637380003296 CoA binding pocket [chemical binding]; other site 637380003297 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 637380003298 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 637380003299 dimer interface [polypeptide binding]; other site 637380003300 active site 637380003301 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 637380003302 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 637380003303 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 637380003304 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 637380003305 active site 637380003306 HIGH motif; other site 637380003307 dimer interface [polypeptide binding]; other site 637380003308 KMSKS motif; other site 637380003309 potential frameshift: common BLAST hit: gi|227815971|ref|YP_002815980.1| putative oligopeptide ABC transporter, oligopeptide-binding protein 637380003310 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637380003311 peptide binding site [polypeptide binding]; other site 637380003312 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 637380003313 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 637380003314 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 637380003315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380003316 dimer interface [polypeptide binding]; other site 637380003317 conserved gate region; other site 637380003318 putative PBP binding loops; other site 637380003319 ABC-ATPase subunit interface; other site 637380003320 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 637380003321 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 637380003322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380003323 dimer interface [polypeptide binding]; other site 637380003324 conserved gate region; other site 637380003325 putative PBP binding loops; other site 637380003326 ABC-ATPase subunit interface; other site 637380003327 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 637380003328 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 637380003329 Walker A/P-loop; other site 637380003330 ATP binding site [chemical binding]; other site 637380003331 Q-loop/lid; other site 637380003332 ABC transporter signature motif; other site 637380003333 Walker B; other site 637380003334 D-loop; other site 637380003335 H-loop/switch region; other site 637380003336 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 637380003337 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 637380003338 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 637380003339 Walker A/P-loop; other site 637380003340 ATP binding site [chemical binding]; other site 637380003341 Q-loop/lid; other site 637380003342 ABC transporter signature motif; other site 637380003343 Walker B; other site 637380003344 D-loop; other site 637380003345 H-loop/switch region; other site 637380003346 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 637380003347 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 637380003348 Rhodopirellula transposase; Region: DDE_Tnp_ISAZ013; pfam07592 637380003349 Integrase core domain; Region: rve; cl01316 637380003350 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637380003351 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 637380003352 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 637380003353 MatE; Region: MatE; pfam01554 637380003354 MatE; Region: MatE; pfam01554 637380003355 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 637380003356 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637380003357 peptide binding site [polypeptide binding]; other site 637380003358 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting...; Region: ArsC_Spx; cd03032 637380003359 putative catalytic residues [active] 637380003360 thiol/disulfide switch; other site 637380003361 Integral membrane protein TerC family; Region: TerC; cl10468 637380003362 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 637380003363 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 637380003364 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 637380003365 putative active site [active] 637380003366 catalytic site [active] 637380003367 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 637380003368 putative active site [active] 637380003369 catalytic site [active] 637380003370 Competence protein CoiA-like family; Region: CoiA; cl11541 637380003371 oligoendopeptidase F; Region: pepF; TIGR00181 637380003372 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 637380003373 active site 637380003374 Zn binding site [ion binding]; other site 637380003375 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 637380003376 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 637380003377 catalytic residues [active] 637380003378 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 637380003379 apolar tunnel; other site 637380003380 heme binding site [chemical binding]; other site 637380003381 dimerization interface [polypeptide binding]; other site 637380003382 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 637380003383 putative active site [active] 637380003384 putative metal binding residues [ion binding]; other site 637380003385 signature motif; other site 637380003386 putative triphosphate binding site [ion binding]; other site 637380003387 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 637380003388 synthetase active site [active] 637380003389 NTP binding site [chemical binding]; other site 637380003390 metal binding site [ion binding]; metal-binding site 637380003391 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 637380003392 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 637380003393 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 637380003394 active site 637380003395 Domain of unknown function (DUF3476); Region: DUF3476; pfam11962 637380003396 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 637380003397 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 637380003398 active site 637380003399 metal binding site [ion binding]; metal-binding site 637380003400 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 637380003401 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 637380003402 active site 637380003403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380003404 S-adenosylmethionine binding site [chemical binding]; other site 637380003405 Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711 637380003406 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 637380003407 putative metal binding site [ion binding]; other site 637380003408 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637380003409 binding surface 637380003410 TPR motif; other site 637380003411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380003412 S-adenosylmethionine binding site [chemical binding]; other site 637380003413 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 637380003414 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 637380003415 active site 637380003416 Cupin domain; Region: Cupin_2; cl09118 637380003417 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 637380003418 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 637380003419 NAD binding site [chemical binding]; other site 637380003420 substrate binding site [chemical binding]; other site 637380003421 homodimer interface [polypeptide binding]; other site 637380003422 active site 637380003423 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 637380003424 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 637380003425 NADP binding site [chemical binding]; other site 637380003426 active site 637380003427 putative substrate binding site [chemical binding]; other site 637380003428 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 637380003429 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 637380003430 NAD binding site [chemical binding]; other site 637380003431 homotetramer interface [polypeptide binding]; other site 637380003432 homodimer interface [polypeptide binding]; other site 637380003433 substrate binding site [chemical binding]; other site 637380003434 active site 637380003435 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 637380003436 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 637380003437 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 637380003438 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 637380003439 UvrD/REP helicase; Region: UvrD-helicase; cl14126 637380003440 UvrD/REP helicase; Region: UvrD-helicase; cl14126 637380003441 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380003442 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380003443 Coenzyme A binding pocket [chemical binding]; other site 637380003444 hypothetical protein; Provisional; Region: PRK13679 637380003445 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 637380003446 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380003447 Putative esterase; Region: Esterase; pfam00756 637380003448 EamA-like transporter family; Region: EamA; cl01037 637380003449 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 637380003450 EamA-like transporter family; Region: EamA; cl01037 637380003451 Protein of unknown function (DUF1200); Region: DUF1200; pfam06713 637380003452 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 637380003453 Sodium:solute symporter family; Region: SSF; cl00456 637380003454 anthranilate synthase component I; Provisional; Region: PRK13570 637380003455 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 637380003456 chorismate binding enzyme; Region: Chorismate_bind; cl10555 637380003457 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 637380003458 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 637380003459 glutamine binding [chemical binding]; other site 637380003460 catalytic triad [active] 637380003461 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 637380003462 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 637380003463 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 637380003464 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 637380003465 active site 637380003466 ribulose/triose binding site [chemical binding]; other site 637380003467 phosphate binding site [ion binding]; other site 637380003468 substrate (anthranilate) binding pocket [chemical binding]; other site 637380003469 product (indole) binding pocket [chemical binding]; other site 637380003470 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 637380003471 active site 637380003472 tryptophan synthase, beta chain; Region: PLN02618 637380003473 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 637380003474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380003475 catalytic residue [active] 637380003476 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 637380003477 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 637380003478 substrate binding site [chemical binding]; other site 637380003479 active site 637380003480 catalytic residues [active] 637380003481 heterodimer interface [polypeptide binding]; other site 637380003482 L-lactate permease; Region: Lactate_perm; cl00701 637380003483 Uncharacterized conserved protein [Function unknown]; Region: COG5634 637380003484 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 637380003485 Double zinc ribbon; Region: DZR; pfam12773 637380003486 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 637380003487 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380003488 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 637380003489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380003490 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the...; Region: mcbC-like_oxidoreductase; cd02142 637380003491 NADPH bind site [chemical binding]; other site 637380003492 putative FMN binding site [chemical binding]; other site 637380003493 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the...; Region: mcbC-like_oxidoreductase; cd02142 637380003494 putative FMN binding site [chemical binding]; other site 637380003495 NADPH bind site [chemical binding]; other site 637380003496 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 637380003497 YcaO-like family; Region: YcaO; cl09146 637380003498 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 637380003499 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 637380003500 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 637380003501 E3 interaction surface; other site 637380003502 lipoyl attachment site [posttranslational modification]; other site 637380003503 e3 binding domain; Region: E3_binding; pfam02817 637380003504 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 637380003505 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 637380003506 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016 637380003507 TPP-binding site [chemical binding]; other site 637380003508 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 637380003509 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380003510 salt bridge; other site 637380003511 non-specific DNA binding site [nucleotide binding]; other site 637380003512 sequence-specific DNA binding site [nucleotide binding]; other site 637380003513 Proteins of 100 residues with WXG; Region: WXG100; cl02005 637380003514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 637380003515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380003516 S-adenosylmethionine binding site [chemical binding]; other site 637380003517 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 637380003518 Beta-lactamase; Region: Beta-lactamase; cl01009 637380003519 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 637380003520 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 637380003521 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637380003522 Catalytic site [active] 637380003523 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 637380003524 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 637380003525 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380003526 non-specific DNA binding site [nucleotide binding]; other site 637380003527 salt bridge; other site 637380003528 sequence-specific DNA binding site [nucleotide binding]; other site 637380003529 Anti-repressor SinI; Region: SinI; pfam08671 637380003530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 637380003531 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 637380003532 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 637380003533 NAD(P) binding site [chemical binding]; other site 637380003534 catalytic residues [active] 637380003535 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 637380003536 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues...; Region: ABC_PotA_N; cd03300 637380003537 Walker A/P-loop; other site 637380003538 ATP binding site [chemical binding]; other site 637380003539 Q-loop/lid; other site 637380003540 ABC transporter signature motif; other site 637380003541 Walker B; other site 637380003542 D-loop; other site 637380003543 H-loop/switch region; other site 637380003544 TOBE domain; Region: TOBE_2; cl01440 637380003545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380003546 dimer interface [polypeptide binding]; other site 637380003547 conserved gate region; other site 637380003548 putative PBP binding loops; other site 637380003549 ABC-ATPase subunit interface; other site 637380003550 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 637380003551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380003552 dimer interface [polypeptide binding]; other site 637380003553 conserved gate region; other site 637380003554 putative PBP binding loops; other site 637380003555 ABC-ATPase subunit interface; other site 637380003556 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 637380003557 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380003558 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 637380003559 active site 637380003560 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 637380003561 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 637380003562 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 637380003563 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 637380003564 active site 637380003565 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 637380003566 cell division protein DedD; Provisional; Region: PRK11633 637380003567 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 637380003568 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 637380003569 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 637380003570 Cysteine-rich domain; Region: CCG; pfam02754 637380003571 Cysteine-rich domain; Region: CCG; pfam02754 637380003572 FAD binding domain; Region: FAD_binding_4; pfam01565 637380003573 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 637380003574 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 637380003575 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 637380003576 Uncharacterized conserved protein [Function unknown]; Region: COG3391 637380003577 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 637380003578 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 637380003579 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380003580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380003581 active site 637380003582 phosphorylation site [posttranslational modification] 637380003583 intermolecular recognition site; other site 637380003584 dimerization interface [polypeptide binding]; other site 637380003585 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380003586 DNA binding site [nucleotide binding] 637380003587 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637380003588 dimerization interface [polypeptide binding]; other site 637380003589 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380003590 dimer interface [polypeptide binding]; other site 637380003591 phosphorylation site [posttranslational modification] 637380003592 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380003593 ATP binding site [chemical binding]; other site 637380003594 Mg2+ binding site [ion binding]; other site 637380003595 G-X-G motif; other site 637380003596 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637380003597 DNA-binding site [nucleotide binding]; DNA binding site 637380003598 FCD domain; Region: FCD; cl11656 637380003599 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 637380003600 Cysteine-rich domain; Region: CCG; pfam02754 637380003601 Cysteine-rich domain; Region: CCG; pfam02754 637380003602 iron-sulfur cluster-binding protein; Region: TIGR00273 637380003603 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 637380003604 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 637380003605 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 637380003606 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 637380003607 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 637380003608 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 637380003609 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 637380003610 Integral membrane protein TerC family; Region: TerC; cl10468 637380003611 BACI_c13430; yybP-ykoY leader, RF00080 637380003612 Cation transport protein; Region: TrkH; cl10514 637380003613 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 637380003614 Cation transport protein; Region: TrkH; cl10514 637380003615 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 637380003616 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of...; Region: R_hydratase; cd03449 637380003617 dimer interaction site [polypeptide binding]; other site 637380003618 substrate-binding tunnel; other site 637380003619 active site 637380003620 catalytic site [active] 637380003621 substrate binding site [chemical binding]; other site 637380003622 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 637380003623 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380003624 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 637380003625 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 637380003626 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 637380003627 NAD(P) binding site [chemical binding]; other site 637380003628 homotetramer interface [polypeptide binding]; other site 637380003629 homodimer interface [polypeptide binding]; other site 637380003630 active site 637380003631 PhaC subunit; Region: PHA_synth_III_C; TIGR01836 637380003632 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 637380003633 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 637380003634 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 637380003635 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 637380003636 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 637380003637 Cation transport protein; Region: TrkH; cl10514 637380003638 potential frameshift: common BLAST hit: gi|227815836|ref|YP_002815845.1| putative iron compound ABC transporter, iron compound-binding 637380003639 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380003640 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380003641 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 637380003642 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380003643 Walker A/P-loop; other site 637380003644 ATP binding site [chemical binding]; other site 637380003645 Q-loop/lid; other site 637380003646 ABC transporter signature motif; other site 637380003647 Walker B; other site 637380003648 D-loop; other site 637380003649 H-loop/switch region; other site 637380003650 TOBE domain; Region: TOBE_2; cl01440 637380003651 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 637380003652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380003653 dimer interface [polypeptide binding]; other site 637380003654 conserved gate region; other site 637380003655 putative PBP binding loops; other site 637380003656 ABC-ATPase subunit interface; other site 637380003657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380003658 dimer interface [polypeptide binding]; other site 637380003659 conserved gate region; other site 637380003660 putative PBP binding loops; other site 637380003661 ABC-ATPase subunit interface; other site 637380003662 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 637380003663 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637380003664 motif II; other site 637380003665 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637380003666 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637380003667 catalytic residue [active] 637380003668 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 637380003669 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 637380003670 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380003671 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 637380003672 potential frameshift: common BLAST hit: gi|118476901|ref|YP_894052.1| internalin 637380003673 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760 637380003674 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760 637380003675 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl14636 637380003676 Substrate binding site [chemical binding]; other site 637380003677 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637380003678 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637380003679 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637380003680 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637380003681 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637380003682 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637380003683 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 637380003684 S-layer homology domain; Region: SLH; pfam00395 637380003685 S-layer homology domain; Region: SLH; pfam00395 637380003686 S-layer homology domain; Region: SLH; pfam00395 637380003687 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 637380003688 intersubunit interface [polypeptide binding]; other site 637380003689 active site 637380003690 Zn2+ binding site [ion binding]; other site 637380003691 FOG: CBS domain [General function prediction only]; Region: COG0517 637380003692 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 637380003693 Divergent polysaccharide deacetylase; Region: Polysacc_deac_2; cl04721 637380003694 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 637380003695 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 637380003696 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380003697 dimer interface [polypeptide binding]; other site 637380003698 phosphorylation site [posttranslational modification] 637380003699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380003700 ATP binding site [chemical binding]; other site 637380003701 Mg2+ binding site [ion binding]; other site 637380003702 G-X-G motif; other site 637380003703 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380003704 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 637380003705 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 637380003706 active site 637380003707 Zn binding site [ion binding]; other site 637380003708 DinB superfamily; Region: DinB_2; cl00986 637380003709 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 637380003710 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380003711 dimer interface [polypeptide binding]; other site 637380003712 phosphorylation site [posttranslational modification] 637380003713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380003714 ATP binding site [chemical binding]; other site 637380003715 Mg2+ binding site [ion binding]; other site 637380003716 G-X-G motif; other site 637380003717 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 637380003718 Ligand Binding Site [chemical binding]; other site 637380003719 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 637380003720 active site 637380003721 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 637380003722 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 637380003723 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 637380003724 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 637380003725 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 637380003726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380003727 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 637380003728 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 637380003729 Class I ribonucleotide reductase; Region: RNR_I; cd01679 637380003730 active site 637380003731 dimer interface [polypeptide binding]; other site 637380003732 catalytic residues [active] 637380003733 effector binding site; other site 637380003734 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08332 637380003735 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 637380003736 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 637380003737 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 637380003738 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 637380003739 dimer interface [polypeptide binding]; other site 637380003740 putative radical transfer pathway; other site 637380003741 diiron center [ion binding]; other site 637380003742 tyrosyl radical; other site 637380003743 Predicted transcriptional regulators [Transcription]; Region: COG1725 637380003744 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637380003745 DNA-binding site [nucleotide binding]; DNA binding site 637380003746 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 637380003747 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 637380003748 Walker A/P-loop; other site 637380003749 ATP binding site [chemical binding]; other site 637380003750 Q-loop/lid; other site 637380003751 ABC transporter signature motif; other site 637380003752 Walker B; other site 637380003753 D-loop; other site 637380003754 H-loop/switch region; other site 637380003755 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637380003756 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 637380003757 Walker A/P-loop; other site 637380003758 ATP binding site [chemical binding]; other site 637380003759 Q-loop/lid; other site 637380003760 ABC transporter signature motif; other site 637380003761 Walker B; other site 637380003762 D-loop; other site 637380003763 H-loop/switch region; other site 637380003764 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637380003765 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 637380003766 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 637380003767 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 637380003768 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380003769 Uncharacterized conserved protein [Function unknown]; Region: COG2128 637380003770 Isochorismatase family; Region: Isochorismatase; pfam00857 637380003771 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 637380003772 catalytic triad [active] 637380003773 conserved cis-peptide bond; other site 637380003774 SseB protein; Region: SseB; cl06279 637380003775 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 637380003776 dimer interface [polypeptide binding]; other site 637380003777 catalytic triad [active] 637380003778 Nitronate monooxygenase; Region: NMO; pfam03060 637380003779 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 637380003780 FMN binding site [chemical binding]; other site 637380003781 substrate binding site [chemical binding]; other site 637380003782 putative catalytic residue [active] 637380003783 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 637380003784 DltD N-terminal region; Region: DltD_N; pfam04915 637380003785 DltD central region; Region: DltD_M; pfam04918 637380003786 DltD C-terminal region; Region: DltD_C; pfam04914 637380003787 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087; cl07963 637380003788 MBOAT family; Region: MBOAT; cl00738 637380003789 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 637380003790 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 637380003791 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 637380003792 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 637380003793 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 637380003794 metal binding site [ion binding]; metal-binding site 637380003795 dimer interface [polypeptide binding]; other site 637380003796 Transposase domain (DUF772); Region: DUF772; cl12084 637380003797 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 637380003798 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637380003799 Phosphotransferase enzyme family; Region: APH; pfam01636 637380003800 active site 637380003801 substrate binding site [chemical binding]; other site 637380003802 ATP binding site [chemical binding]; other site 637380003803 multidrug efflux protein; Reviewed; Region: PRK01766 637380003804 MatE; Region: MatE; pfam01554 637380003805 MatE; Region: MatE; pfam01554 637380003806 Bacitracin resistance protein BacA; Region: BacA; cl00858 637380003807 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380003808 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 637380003809 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 637380003810 Cation transport protein; Region: TrkH; cl10514 637380003811 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 637380003812 Uncharacterised protein family (UPF0180); Region: UPF0180; cl04214 637380003813 branched-chain amino acid aminotransferase; Provisional; Region: PRK12479 637380003814 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-...; Region: D-AAT_like; cd01558 637380003815 homodimer interface [polypeptide binding]; other site 637380003816 substrate-cofactor binding pocket; other site 637380003817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380003818 catalytic residue [active] 637380003819 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 637380003820 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 637380003821 PYR/PP interface [polypeptide binding]; other site 637380003822 dimer interface [polypeptide binding]; other site 637380003823 TPP binding site [chemical binding]; other site 637380003824 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637380003825 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 637380003826 TPP-binding site [chemical binding]; other site 637380003827 dimer interface [polypeptide binding]; other site 637380003828 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 637380003829 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 637380003830 putative valine binding site [chemical binding]; other site 637380003831 dimer interface [polypeptide binding]; other site 637380003832 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 637380003833 ketol-acid reductoisomerase; Provisional; Region: PRK05479 637380003834 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380003835 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 637380003836 2-isopropylmalate synthase; Validated; Region: PRK00915 637380003837 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 637380003838 active site 637380003839 catalytic residues [active] 637380003840 metal binding site [ion binding]; metal-binding site 637380003841 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 637380003842 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 637380003843 isocitrate dehydrogenase; Validated; Region: PRK06451 637380003844 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 637380003845 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 637380003846 substrate binding site [chemical binding]; other site 637380003847 ligand binding site [chemical binding]; other site 637380003848 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 637380003849 substrate binding site [chemical binding]; other site 637380003850 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 637380003851 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 637380003852 dimer interface [polypeptide binding]; other site 637380003853 motif 1; other site 637380003854 active site 637380003855 motif 2; other site 637380003856 motif 3; other site 637380003857 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380003858 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 637380003859 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 637380003860 NAD binding site [chemical binding]; other site 637380003861 dimerization interface [polypeptide binding]; other site 637380003862 product binding site; other site 637380003863 substrate binding site [chemical binding]; other site 637380003864 zinc binding site [ion binding]; other site 637380003865 catalytic residues [active] 637380003866 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 637380003867 putative active site pocket [active] 637380003868 4-fold oligomerization interface [polypeptide binding]; other site 637380003869 metal binding residues [ion binding]; metal-binding site 637380003870 3-fold/trimer interface [polypeptide binding]; other site 637380003871 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 637380003872 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 637380003873 putative active site [active] 637380003874 oxyanion strand; other site 637380003875 catalytic triad [active] 637380003876 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 637380003877 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 637380003878 catalytic residues [active] 637380003879 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 637380003880 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 637380003881 substrate binding site [chemical binding]; other site 637380003882 glutamase interaction surface [polypeptide binding]; other site 637380003883 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 637380003884 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 637380003885 histidinol-phosphatase; Validated; Region: PRK06740 637380003886 glyoxylate reductase; Reviewed; Region: PRK13243 637380003887 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380003888 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 637380003889 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 637380003890 Sulfatase; Region: Sulfatase; cl10460 637380003891 diaminopimelate decarboxylase; Region: lysA; TIGR01048 637380003892 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 637380003893 active site 637380003894 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637380003895 substrate binding site [chemical binding]; other site 637380003896 catalytic residues [active] 637380003897 dimer interface [polypeptide binding]; other site 637380003898 Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371 637380003899 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 637380003900 Active Sites [active] 637380003901 ATP sulfurylase (sulfate adenylyltransferase) [Inorganic ion transport and metabolism]; Region: MET3; COG2046 637380003902 ATP-sulfurylase; Region: ATPS; cd00517 637380003903 active site 637380003904 HXXH motif; other site 637380003905 flexible loop; other site 637380003906 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 637380003907 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 637380003908 ligand-binding site [chemical binding]; other site 637380003909 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 637380003910 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 637380003911 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 637380003912 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 637380003913 diphthine synthase; Region: dph5; TIGR00522 637380003914 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 637380003915 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416 637380003916 putative active site [active] 637380003917 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_C; cd03414 637380003918 putative active site [active] 637380003919 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 637380003920 precorrin-2 dehydrogenase; Validated; Region: PRK06719 637380003921 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 637380003922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 637380003923 Peptidase family M23; Region: Peptidase_M23; pfam01551 637380003924 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 637380003925 Protein of unknown function (DUF402); Region: DUF402; cl00979 637380003926 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 637380003927 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380003928 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380003929 PspA/IM30 family; Region: PspA_IM30; pfam04012 637380003930 Predicted membrane protein (DUF2154); Region: DUF2154; cl12089 637380003931 Histidine kinase; Region: HisKA_3; pfam07730 637380003932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380003933 ATP binding site [chemical binding]; other site 637380003934 Mg2+ binding site [ion binding]; other site 637380003935 G-X-G motif; other site 637380003936 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637380003937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380003938 active site 637380003939 phosphorylation site [posttranslational modification] 637380003940 intermolecular recognition site; other site 637380003941 dimerization interface [polypeptide binding]; other site 637380003942 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 637380003943 DNA binding residues [nucleotide binding] 637380003944 dimerization interface [polypeptide binding]; other site 637380003945 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 637380003946 E3 interaction surface; other site 637380003947 lipoyl attachment site [posttranslational modification]; other site 637380003948 potential frameshift: common BLAST hit: gi|118477000|ref|YP_894151.1| branched-chain amino acid transport protein 637380003949 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 637380003950 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 637380003951 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 637380003952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380003953 S-adenosylmethionine binding site [chemical binding]; other site 637380003954 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 637380003955 active site 637380003956 putative substrate binding region [chemical binding]; other site 637380003957 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 637380003958 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 637380003959 heme-binding site [chemical binding]; other site 637380003960 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 637380003961 FAD binding pocket [chemical binding]; other site 637380003962 FAD binding motif [chemical binding]; other site 637380003963 phosphate binding motif [ion binding]; other site 637380003964 beta-alpha-beta structure motif; other site 637380003965 NAD binding pocket [chemical binding]; other site 637380003966 Heme binding pocket [chemical binding]; other site 637380003967 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 637380003968 ligand binding site [chemical binding]; other site 637380003969 flexible hinge region; other site 637380003970 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 637380003971 Phosphate transporter family; Region: PHO4; cl00396 637380003972 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 637380003973 Transglycosylase; Region: Transgly; cl07896 637380003974 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 637380003975 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 637380003976 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 637380003977 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 637380003978 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 637380003979 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380003980 dimer interface [polypeptide binding]; other site 637380003981 phosphorylation site [posttranslational modification] 637380003982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380003983 ATP binding site [chemical binding]; other site 637380003984 Mg2+ binding site [ion binding]; other site 637380003985 G-X-G motif; other site 637380003986 Protein of unknown function DUF72; Region: DUF72; cl00777 637380003987 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 637380003988 Phage integrase family; Region: Phage_integrase; pfam00589 637380003989 DNA binding site [nucleotide binding] 637380003990 Int/Topo IB signature motif; other site 637380003991 active site 637380003992 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637380003993 dimerization interface [polypeptide binding]; other site 637380003994 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380003995 dimer interface [polypeptide binding]; other site 637380003996 phosphorylation site [posttranslational modification] 637380003997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380003998 ATP binding site [chemical binding]; other site 637380003999 Mg2+ binding site [ion binding]; other site 637380004000 G-X-G motif; other site 637380004001 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 637380004002 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 637380004003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 637380004004 Probable transposase; Region: OrfB_IS605; pfam01385 637380004005 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 637380004006 Predicted integral membrane protein [Function unknown]; Region: COG0392 637380004007 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 637380004008 Uncharacterized conserved protein [Function unknown]; Region: COG2898 637380004009 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 637380004010 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 637380004011 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 637380004012 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 637380004013 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 637380004014 Beta-lactamase; Region: Beta-lactamase; cl01009 637380004015 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 637380004016 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 637380004017 Nucleoside recognition; Region: Gate; cl00486 637380004018 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 637380004019 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637380004020 RNA binding surface [nucleotide binding]; other site 637380004021 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 637380004022 active site 637380004023 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 637380004024 catalytic residues [active] 637380004025 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 637380004026 ResB-like family; Region: ResB; pfam05140 637380004027 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 637380004028 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 637380004029 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380004030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380004031 active site 637380004032 phosphorylation site [posttranslational modification] 637380004033 intermolecular recognition site; other site 637380004034 dimerization interface [polypeptide binding]; other site 637380004035 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380004036 DNA binding site [nucleotide binding] 637380004037 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 637380004038 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637380004039 dimerization interface [polypeptide binding]; other site 637380004040 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 637380004041 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380004042 dimer interface [polypeptide binding]; other site 637380004043 phosphorylation site [posttranslational modification] 637380004044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380004045 ATP binding site [chemical binding]; other site 637380004046 Mg2+ binding site [ion binding]; other site 637380004047 G-X-G motif; other site 637380004048 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 637380004049 Peptidase family M23; Region: Peptidase_M23; pfam01551 637380004050 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 637380004051 putative peptidoglycan binding site; other site 637380004052 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 637380004053 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 637380004054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 637380004055 DEAD-like helicases superfamily; Region: DEXDc; smart00487 637380004056 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637380004057 ATP binding site [chemical binding]; other site 637380004058 putative Mg++ binding site [ion binding]; other site 637380004059 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637380004060 nucleotide binding region [chemical binding]; other site 637380004061 ATP-binding site [chemical binding]; other site 637380004062 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 637380004063 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 637380004064 putative peptidoglycan binding site; other site 637380004065 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 637380004066 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637380004067 putative active site [active] 637380004068 putative metal binding site [ion binding]; other site 637380004069 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 637380004070 DNA binding residues [nucleotide binding] 637380004071 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 637380004072 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 637380004073 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 637380004074 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 637380004075 NAD(P) binding site [chemical binding]; other site 637380004076 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 637380004077 amidase catalytic site [active] 637380004078 Zn binding residues [ion binding]; other site 637380004079 substrate binding site [chemical binding]; other site 637380004080 putative bacillithiol system thiol disulfide oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 637380004081 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380004082 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380004083 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 637380004084 active site/substrate binding site [active] 637380004085 tetramer interface [polypeptide binding]; other site 637380004086 cytidylate kinase; Provisional; Region: cmk; PRK00023 637380004087 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 637380004088 CMP-binding site; other site 637380004089 The sites determining sugar specificity; other site 637380004090 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 637380004091 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 637380004092 RNA binding site [nucleotide binding]; other site 637380004093 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 637380004094 RNA binding site [nucleotide binding]; other site 637380004095 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 637380004096 RNA binding site [nucleotide binding]; other site 637380004097 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 637380004098 RNA binding site [nucleotide binding]; other site 637380004099 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 637380004100 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal...; Region: IDI-2_FMN; cd02811 637380004101 homotetramer interface [polypeptide binding]; other site 637380004102 FMN binding site [chemical binding]; other site 637380004103 homodimer contacts [polypeptide binding]; other site 637380004104 putative active site [active] 637380004105 putative substrate binding site [chemical binding]; other site 637380004106 GTP-binding protein Der; Reviewed; Region: PRK00093 637380004107 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 637380004108 G1 box; other site 637380004109 GTP/Mg2+ binding site [chemical binding]; other site 637380004110 Switch I region; other site 637380004111 G2 box; other site 637380004112 Switch II region; other site 637380004113 G3 box; other site 637380004114 G4 box; other site 637380004115 G5 box; other site 637380004116 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 637380004117 G1 box; other site 637380004118 GTP/Mg2+ binding site [chemical binding]; other site 637380004119 Switch I region; other site 637380004120 G2 box; other site 637380004121 G3 box; other site 637380004122 Switch II region; other site 637380004123 G4 box; other site 637380004124 G5 box; other site 637380004125 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 637380004126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380004127 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 637380004128 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 637380004129 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 637380004130 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 637380004131 IHF dimer interface [polypeptide binding]; other site 637380004132 IHF - DNA interface [nucleotide binding]; other site 637380004133 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 637380004134 homodecamer interface [polypeptide binding]; other site 637380004135 GTP cyclohydrolase I; Provisional; Region: PLN03044 637380004136 active site 637380004137 putative catalytic site residues [active] 637380004138 zinc binding site [ion binding]; other site 637380004139 GTP-CH-I/GFRP interaction surface; other site 637380004140 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 637380004141 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 637380004142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380004143 S-adenosylmethionine binding site [chemical binding]; other site 637380004144 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 637380004145 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 637380004146 substrate binding pocket [chemical binding]; other site 637380004147 chain length determination region; other site 637380004148 substrate-Mg2+ binding site; other site 637380004149 catalytic residues [active] 637380004150 aspartate-rich region 1; other site 637380004151 active site lid residues [active] 637380004152 aspartate-rich region 2; other site 637380004153 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 637380004154 active site 637380004155 multimer interface [polypeptide binding]; other site 637380004156 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 637380004157 Tetramer interface [polypeptide binding]; other site 637380004158 Active site [active] 637380004159 FMN-binding site [chemical binding]; other site 637380004160 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 637380004161 active site 637380004162 dimer interface [polypeptide binding]; other site 637380004163 metal binding site [ion binding]; metal-binding site 637380004164 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 637380004165 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637380004166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380004167 homodimer interface [polypeptide binding]; other site 637380004168 catalytic residue [active] 637380004169 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 637380004170 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 637380004171 binding surface 637380004172 TPR motif; other site 637380004173 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637380004174 binding surface 637380004175 TPR motif; other site 637380004176 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637380004177 binding surface 637380004178 TPR motif; other site 637380004179 hypothetical protein; Provisional; Region: PRK03636 637380004180 UPF0302 domain; Region: UPF0302; pfam08864 637380004181 IDEAL domain; Region: IDEAL; pfam08858 637380004182 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 637380004183 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 637380004184 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 637380004185 iron-sulfur cluster [ion binding]; other site 637380004186 [2Fe-2S] cluster binding site [ion binding]; other site 637380004187 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cd00284 637380004188 interchain domain interface [polypeptide binding]; other site 637380004189 intrachain domain interface; other site 637380004190 heme bH binding site [chemical binding]; other site 637380004191 Qi binding site; other site 637380004192 heme bL binding site [chemical binding]; other site 637380004193 Qo binding site; other site 637380004194 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: cytochrome_b_C; cl00193 637380004195 Cytochrome c; Region: Cytochrom_C; cl11414 637380004196 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 637380004197 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 637380004198 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 637380004199 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 637380004200 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 637380004201 Uncharacterized conserved protein [Function unknown]; Region: COG1284 637380004202 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637380004203 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637380004204 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 637380004205 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 637380004206 dihydrodipicolinate reductase; Provisional; Region: PRK00048 637380004207 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380004208 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 637380004209 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 637380004210 active site 637380004211 dimer interfaces [polypeptide binding]; other site 637380004212 catalytic residues [active] 637380004213 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 637380004214 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 637380004215 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_5; cd04962 637380004216 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 637380004217 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 637380004218 active site 637380004219 NTP binding site [chemical binding]; other site 637380004220 metal binding triad [ion binding]; metal-binding site 637380004221 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 637380004222 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380004223 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 637380004224 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 637380004225 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 637380004226 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 637380004227 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 637380004228 oligomerization interface [polypeptide binding]; other site 637380004229 active site 637380004230 metal binding site [ion binding]; metal-binding site 637380004231 pantoate--beta-alanine ligase; Region: panC; TIGR00018 637380004232 Pantoate-beta-alanine ligase; Region: PanC; cd00560 637380004233 active site 637380004234 ATP-binding site [chemical binding]; other site 637380004235 pantoate-binding site; other site 637380004236 HXXH motif; other site 637380004237 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 637380004238 tetramerization interface [polypeptide binding]; other site 637380004239 active site 637380004240 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 637380004241 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 637380004242 active site 637380004243 substrate binding site [chemical binding]; other site 637380004244 catalytic site [active] 637380004245 DEAD_2; Region: DEAD_2; cl14887 637380004246 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250 637380004247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 637380004248 aspartate aminotransferase; Provisional; Region: PRK08361 637380004249 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637380004250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380004251 homodimer interface [polypeptide binding]; other site 637380004252 catalytic residue [active] 637380004253 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380004254 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 637380004255 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 637380004256 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 637380004257 minor groove reading motif; other site 637380004258 helix-hairpin-helix signature motif; other site 637380004259 substrate binding pocket [chemical binding]; other site 637380004260 active site 637380004261 FES domain; Region: FES; smart00525 637380004262 Transglycosylase; Region: Transgly; cl07896 637380004263 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 637380004264 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 637380004265 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637380004266 Interdomain contacts; other site 637380004267 Cytokine receptor motif; other site 637380004268 Recombination protein U; Region: RecU; cl01314 637380004269 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 637380004270 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 637380004271 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 637380004272 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 637380004273 cell division protein GpsB; Provisional; Region: PRK14127 637380004274 DivIVA domain; Region: DivI1A_domain; TIGR03544 637380004275 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 637380004276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380004277 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 637380004278 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250 637380004279 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250 637380004280 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 637380004281 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 637380004282 active site 637380004283 Zn binding site [ion binding]; other site 637380004284 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380004285 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: MPH2'; cd05152 637380004286 Phosphotransferase enzyme family; Region: APH; pfam01636 637380004287 putative active site [active] 637380004288 putative substrate binding site [chemical binding]; other site 637380004289 ATP binding site [chemical binding]; other site 637380004290 methionine aminopeptidase; Reviewed; Region: PRK07281 637380004291 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 637380004292 active site 637380004293 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 637380004294 Permease family; Region: Xan_ur_permease; pfam00860 637380004295 Sulfate transporter family; Region: Sulfate_transp; cl00967 637380004296 Predicted membrane protein [Function unknown]; Region: COG2311 637380004297 Protein of unknown function (DUF418); Region: DUF418; cl12135 637380004298 Protein of unknown function (DUF418); Region: DUF418; cl12135 637380004299 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 637380004300 G1 box; other site 637380004301 GTP/Mg2+ binding site [chemical binding]; other site 637380004302 Switch I region; other site 637380004303 G2 box; other site 637380004304 Switch II region; other site 637380004305 G3 box; other site 637380004306 G4 box; other site 637380004307 GTPase [General function prediction only]; Region: Era; COG1159 637380004308 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 637380004309 G1 box; other site 637380004310 GTP/Mg2+ binding site [chemical binding]; other site 637380004311 Switch I region; other site 637380004312 G2 box; other site 637380004313 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380004314 Coenzyme A binding pocket [chemical binding]; other site 637380004315 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 637380004316 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 637380004317 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 637380004318 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 637380004319 active site residue [active] 637380004320 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 637380004321 active site residue [active] 637380004322 Glutathionylspermidine synthase; Region: GSP_synth; cl00503 637380004323 Predicted membrane protein [Function unknown]; Region: COG3766 637380004324 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 637380004325 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 637380004326 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637380004327 5'-3' exonuclease; Region: 53EXOc; smart00475 637380004328 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 637380004329 active site 637380004330 metal binding site 1 [ion binding]; metal-binding site 637380004331 putative 5' ssDNA interaction site; other site 637380004332 metal binding site 3; metal-binding site 637380004333 metal binding site 2 [ion binding]; metal-binding site 637380004334 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 637380004335 putative DNA binding site [nucleotide binding]; other site 637380004336 putative metal binding site [ion binding]; other site 637380004337 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 637380004338 Chain length determinant protein; Region: Wzz; cl01623 637380004339 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 637380004340 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 637380004341 Bacterial sugar transferase; Region: Bac_transf; cl00939 637380004342 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 637380004343 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 637380004344 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 637380004345 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 637380004346 O-Antigen ligase; Region: Wzy_C; cl04850 637380004347 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 637380004348 active site 637380004349 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 637380004350 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 637380004351 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004352 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004353 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004354 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004355 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004356 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004357 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004358 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004359 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004360 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004361 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004362 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004363 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004364 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004365 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004366 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004367 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004368 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004369 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004370 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004371 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004372 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004373 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004374 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004375 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004376 Domain of unknown function DUF11; Region: DUF11; cl03172 637380004377 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 637380004378 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380004379 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 637380004380 catalytic triad [active] 637380004381 conserved cis-peptide bond; other site 637380004382 EamA-like transporter family; Region: EamA; cl01037 637380004383 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 637380004384 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 637380004385 RNA/DNA hybrid binding site [nucleotide binding]; other site 637380004386 active site 637380004387 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 637380004388 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 637380004389 active site 637380004390 catalytic residues [active] 637380004391 QueT transporter; Region: QueT; cl01932 637380004392 hypothetical protein; Validated; Region: PRK07708 637380004393 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 637380004394 RNA/DNA hybrid binding site [nucleotide binding]; other site 637380004395 active site 637380004396 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 637380004397 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 637380004398 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 637380004399 DNA-binding site [nucleotide binding]; DNA binding site 637380004400 RNA-binding motif; other site 637380004401 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 637380004402 LysE type translocator; Region: LysE; cl00565 637380004403 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 637380004404 Protein of unknown function, DUF485; Region: DUF485; cl01231 637380004405 Sodium:solute symporter family; Region: SSF; cl00456 637380004406 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 637380004407 aminotransferase; Validated; Region: PRK07678 637380004408 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 637380004409 inhibitor-cofactor binding pocket; inhibition site 637380004410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380004411 catalytic residue [active] 637380004412 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 637380004413 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 637380004414 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 637380004415 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380004416 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 637380004417 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 637380004418 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 637380004419 DNA binding residues [nucleotide binding] 637380004420 drug binding residues [chemical binding]; other site 637380004421 dimer interface [polypeptide binding]; other site 637380004422 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 637380004423 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 637380004424 MatE; Region: MatE; pfam01554 637380004425 MatE; Region: MatE; pfam01554 637380004426 Protein of unknown function (DUF421); Region: DUF421; cl00990 637380004427 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 637380004428 putative active site [active] 637380004429 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH...; Region: NfsA_FRP; cd02146 637380004430 dimer interface [polypeptide binding]; other site 637380004431 FMN binding site [chemical binding]; other site 637380004432 NADPH bind site [chemical binding]; other site 637380004433 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 637380004434 conserved cys residue [active] 637380004435 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 637380004436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380004437 H+ Antiporter protein; Region: 2A0121; TIGR00900 637380004438 putative substrate translocation pore; other site 637380004439 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637380004440 dimerization interface [polypeptide binding]; other site 637380004441 putative DNA binding site [nucleotide binding]; other site 637380004442 putative Zn2+ binding site [ion binding]; other site 637380004443 H+ Antiporter protein; Region: 2A0121; TIGR00900 637380004444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380004445 putative substrate translocation pore; other site 637380004446 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 637380004447 active site 637380004448 metal binding site [ion binding]; metal-binding site 637380004449 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 637380004450 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 637380004451 Sm1 motif; other site 637380004452 D3 - B interaction site; other site 637380004453 D1 - D2 interaction site; other site 637380004454 Hfq - Hfq interaction site; other site 637380004455 RNA binding pocket [nucleotide binding]; other site 637380004456 Sm2 motif; other site 637380004457 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 637380004458 flagellar motor protein MotP; Reviewed; Region: PRK06926 637380004459 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 637380004460 flagellar motor protein MotS; Reviewed; Region: PRK06742 637380004461 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 637380004462 ligand binding site [chemical binding]; other site 637380004463 Response regulator receiver domain; Region: Response_reg; pfam00072 637380004464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380004465 active site 637380004466 phosphorylation site [posttranslational modification] 637380004467 intermolecular recognition site; other site 637380004468 dimerization interface [polypeptide binding]; other site 637380004469 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 637380004470 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 637380004471 putative binding surface; other site 637380004472 active site 637380004473 P2 response regulator binding domain; Region: P2; pfam07194 637380004474 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 637380004475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380004476 ATP binding site [chemical binding]; other site 637380004477 Mg2+ binding site [ion binding]; other site 637380004478 G-X-G motif; other site 637380004479 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 637380004480 flagellar motor switch protein; Reviewed; Region: PRK06782 637380004481 CheC-like family; Region: CheC; pfam04509 637380004482 CheC-like family; Region: CheC; pfam04509 637380004483 CheC-like family; Region: CheC; pfam04509 637380004484 CheC-like family; Region: CheC; pfam04509 637380004485 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 637380004486 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 637380004487 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 637380004488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380004489 Protein of unknown function (DUF327); Region: DUF327; cl00753 637380004490 Glutamate-cysteine ligase; Region: GshA; pfam08886 637380004491 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 637380004492 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 637380004493 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 637380004494 flagellar capping protein; Validated; Region: fliD; PRK06798 637380004495 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 637380004496 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 637380004497 Flagellar protein FliS; Region: FliS; cl00654 637380004498 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 637380004499 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 637380004500 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 637380004501 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 637380004502 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 637380004503 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 637380004504 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 637380004505 FliG C-terminal domain; Region: FliG_C; pfam01706 637380004506 flagellar assembly protein H; Validated; Region: fliH; PRK06800 637380004507 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 637380004508 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380004509 Walker A motif; other site 637380004510 ATP binding site [chemical binding]; other site 637380004511 Walker B motif; other site 637380004512 Flagellar hook-length control protein FliK; Region: Flg_hook; cl14669 637380004513 Flagellar hook capping protein; Region: FlgD; cl04347 637380004514 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 637380004515 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 637380004516 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 637380004517 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 637380004518 putative CheA interaction surface; other site 637380004519 Response regulator receiver domain; Region: Response_reg; pfam00072 637380004520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380004521 active site 637380004522 phosphorylation site [posttranslational modification] 637380004523 intermolecular recognition site; other site 637380004524 dimerization interface [polypeptide binding]; other site 637380004525 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 637380004526 flagellin; Provisional; Region: PRK12807 637380004527 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 637380004528 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 637380004529 flagellin; Reviewed; Region: PRK08869 637380004530 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 637380004531 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 637380004532 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 637380004533 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 637380004534 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637380004535 catalytic residue [active] 637380004536 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 637380004537 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 637380004538 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 637380004539 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 637380004540 FliP family; Region: FliP; cl00593 637380004541 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 637380004542 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 637380004543 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 637380004544 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 637380004545 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 637380004546 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 637380004547 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889 637380004548 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 637380004549 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 637380004550 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 637380004551 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 637380004552 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 637380004553 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 637380004554 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 637380004555 Predicted transcriptional regulators [Transcription]; Region: COG1378 637380004556 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380004557 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 637380004558 C-terminal domain interface [polypeptide binding]; other site 637380004559 sugar binding site [chemical binding]; other site 637380004560 AzlC protein; Region: AzlC; cl00570 637380004561 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 637380004562 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380004563 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380004564 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 637380004565 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 637380004566 Small acid-soluble spore protein H family; Region: SspH; cl06949 637380004567 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380004568 non-specific DNA binding site [nucleotide binding]; other site 637380004569 salt bridge; other site 637380004570 sequence-specific DNA binding site [nucleotide binding]; other site 637380004571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380004572 H+ Antiporter protein; Region: 2A0121; TIGR00900 637380004573 putative substrate translocation pore; other site 637380004574 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637380004575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380004576 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637380004577 dimerization interface [polypeptide binding]; other site 637380004578 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 637380004579 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380004580 Walker A/P-loop; other site 637380004581 ATP binding site [chemical binding]; other site 637380004582 Q-loop/lid; other site 637380004583 ABC transporter signature motif; other site 637380004584 Walker B; other site 637380004585 D-loop; other site 637380004586 H-loop/switch region; other site 637380004587 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 637380004588 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380004589 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 637380004590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380004591 dimer interface [polypeptide binding]; other site 637380004592 conserved gate region; other site 637380004593 putative PBP binding loops; other site 637380004594 ABC-ATPase subunit interface; other site 637380004595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380004596 dimer interface [polypeptide binding]; other site 637380004597 conserved gate region; other site 637380004598 putative PBP binding loops; other site 637380004599 ABC-ATPase subunit interface; other site 637380004600 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 637380004601 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380004602 Beta-Casp domain; Region: Beta-Casp; pfam10996 637380004603 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 637380004604 Uncharacterised protein from bacillus cereus group; Region: YfmQ; pfam10787 637380004605 Cupin domain; Region: Cupin_2; cl09118 637380004606 Beta-lactamase; Region: Beta-lactamase; cl01009 637380004607 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637380004608 catalytic core [active] 637380004609 hypothetical protein; Provisional; Region: PRK09272 637380004610 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380004611 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 637380004612 active site 637380004613 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 637380004614 dimer interface [polypeptide binding]; other site 637380004615 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 637380004616 Ligand Binding Site [chemical binding]; other site 637380004617 Molecular Tunnel; other site 637380004618 RNA polymerase factor sigma-70; Validated; Region: PRK06811 637380004619 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637380004620 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 637380004621 DNA binding residues [nucleotide binding] 637380004622 VPS10 domain; Region: VPS10; smart00602 637380004623 Cation efflux family; Region: Cation_efflux; cl00316 637380004624 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637380004625 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 637380004626 DNA-binding site [nucleotide binding]; DNA binding site 637380004627 FCD domain; Region: FCD; cl11656 637380004628 potential frameshift: common BLAST hit: gi|227815416|ref|YP_002815425.1| transporter, EamA family 637380004629 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 637380004630 EamA-like transporter family; Region: EamA; cl01037 637380004631 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 637380004632 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 637380004633 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 637380004634 G4 box; other site 637380004635 G5 box; other site 637380004636 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 637380004637 Predicted permease; Region: DUF318; cl00487 637380004638 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 637380004639 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 637380004640 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380004641 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380004642 fumarate hydratase; Reviewed; Region: fumC; PRK00485 637380004643 Class II fumarases; Region: Fumarase_classII; cd01362 637380004644 active site 637380004645 tetramer interface [polypeptide binding]; other site 637380004646 Protein of unknown function (DUF1200); Region: DUF1200; pfam06713 637380004647 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 637380004648 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 637380004649 MatE; Region: MatE; pfam01554 637380004650 MatE; Region: MatE; pfam01554 637380004651 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 637380004652 active site pocket [active] 637380004653 oxyanion hole [active] 637380004654 catalytic triad [active] 637380004655 active site nucleophile [active] 637380004656 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380004657 Peptidase family M48; Region: Peptidase_M48; cl12018 637380004658 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 637380004659 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 637380004660 catalytic residues [active] 637380004661 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 637380004662 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 637380004663 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380004664 non-specific DNA binding site [nucleotide binding]; other site 637380004665 salt bridge; other site 637380004666 sequence-specific DNA binding site [nucleotide binding]; other site 637380004667 Cupin domain; Region: Cupin_2; cl09118 637380004668 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 637380004669 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 637380004670 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637380004671 catalytic residue [active] 637380004672 Protein of unknown function (DUF445); Region: DUF445; pfam04286 637380004673 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 637380004674 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637380004675 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 637380004676 DNA binding residues [nucleotide binding] 637380004677 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637380004678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380004679 active site 637380004680 phosphorylation site [posttranslational modification] 637380004681 intermolecular recognition site; other site 637380004682 dimerization interface [polypeptide binding]; other site 637380004683 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 637380004684 DNA binding residues [nucleotide binding] 637380004685 dimerization interface [polypeptide binding]; other site 637380004686 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 637380004687 Histidine kinase; Region: HisKA_3; pfam07730 637380004688 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380004689 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 637380004690 Walker A/P-loop; other site 637380004691 ATP binding site [chemical binding]; other site 637380004692 Q-loop/lid; other site 637380004693 ABC transporter signature motif; other site 637380004694 Walker B; other site 637380004695 D-loop; other site 637380004696 H-loop/switch region; other site 637380004697 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 637380004698 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637380004699 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637380004700 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 637380004701 putative active site [active] 637380004702 catalytic site [active] 637380004703 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 637380004704 putative active site [active] 637380004705 catalytic site [active] 637380004706 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 637380004707 putative nucleotide binding site [chemical binding]; other site 637380004708 uridine monophosphate binding site [chemical binding]; other site 637380004709 homohexameric interface [polypeptide binding]; other site 637380004710 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 637380004711 aspartate ammonia-lyase; Provisional; Region: PRK14515 637380004712 Aspartase; Region: Aspartase; cd01357 637380004713 active sites [active] 637380004714 tetramer interface [polypeptide binding]; other site 637380004715 malate dehydrogenase; Provisional; Region: PRK13529 637380004716 Malic enzyme, N-terminal domain; Region: malic; pfam00390 637380004717 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 637380004718 NAD(P) binding site [chemical binding]; other site 637380004719 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637380004720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380004721 ATP binding site [chemical binding]; other site 637380004722 Mg2+ binding site [ion binding]; other site 637380004723 G-X-G motif; other site 637380004724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380004725 Response regulator receiver domain; Region: Response_reg; pfam00072 637380004726 active site 637380004727 phosphorylation site [posttranslational modification] 637380004728 intermolecular recognition site; other site 637380004729 dimerization interface [polypeptide binding]; other site 637380004730 YcbB domain; Region: YcbB; pfam08664 637380004731 Uncharacterized conserved protein [Function unknown]; Region: COG4715 637380004732 SWIM zinc finger; Region: SWIM; cl11618 637380004733 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 637380004734 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 637380004735 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637380004736 ATP binding site [chemical binding]; other site 637380004737 putative Mg++ binding site [ion binding]; other site 637380004738 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 637380004739 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637380004740 nucleotide binding region [chemical binding]; other site 637380004741 ATP-binding site [chemical binding]; other site 637380004742 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 637380004743 dimer interface [polypeptide binding]; other site 637380004744 active site 637380004745 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 637380004746 aspartate kinase; Reviewed; Region: PRK06635 637380004747 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 637380004748 putative nucleotide binding site [chemical binding]; other site 637380004749 putative catalytic residues [active] 637380004750 putative Mg ion binding site [ion binding]; other site 637380004751 putative aspartate binding site [chemical binding]; other site 637380004752 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 637380004753 putative allosteric regulatory site; other site 637380004754 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 637380004755 putative allosteric regulatory residue; other site 637380004756 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 637380004757 putative active site [active] 637380004758 nucleotide binding site [chemical binding]; other site 637380004759 nudix motif; other site 637380004760 putative metal binding site [ion binding]; other site 637380004761 S-layer homology domain; Region: SLH; pfam00395 637380004762 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 637380004763 active site 637380004764 metal binding site [ion binding]; metal-binding site 637380004765 S-layer homology domain; Region: SLH; pfam00395 637380004766 S-layer homology domain; Region: SLH; pfam00395 637380004767 S-layer homology domain; Region: SLH; pfam00395 637380004768 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 637380004769 H+ Antiporter protein; Region: 2A0121; TIGR00900 637380004770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380004771 putative substrate translocation pore; other site 637380004772 Carbon starvation protein CstA; Region: CstA; cl00856 637380004773 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380004774 Active site [active] 637380004775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380004776 putative substrate translocation pore; other site 637380004777 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 637380004778 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 637380004779 dimer interface [polypeptide binding]; other site 637380004780 active site 637380004781 CoA binding pocket [chemical binding]; other site 637380004782 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 637380004783 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 637380004784 G1 box; other site 637380004785 GTP/Mg2+ binding site [chemical binding]; other site 637380004786 Switch I region; other site 637380004787 G2 box; other site 637380004788 G3 box; other site 637380004789 Switch II region; other site 637380004790 G4 box; other site 637380004791 G5 box; other site 637380004792 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 637380004793 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637380004794 peptide binding site [polypeptide binding]; other site 637380004795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380004796 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637380004797 putative substrate translocation pore; other site 637380004798 cysteine synthases; Region: cysKM; TIGR01136 637380004799 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 637380004800 dimer interface [polypeptide binding]; other site 637380004801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380004802 catalytic residue [active] 637380004803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380004804 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 637380004805 stage V sporulation protein B; Region: spore_V_B; TIGR02900 637380004806 MatE; Region: MatE; pfam01554 637380004807 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 637380004808 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 637380004809 Protein of unknown function (DUF421); Region: DUF421; cl00990 637380004810 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 637380004811 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 637380004812 short chain dehydrogenase; Provisional; Region: PRK12746 637380004813 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 637380004814 NADP binding site [chemical binding]; other site 637380004815 homodimer interface [polypeptide binding]; other site 637380004816 active site 637380004817 substrate binding site [chemical binding]; other site 637380004818 branched-chain amino acid aminotransferase; Provisional; Region: PRK12479 637380004819 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-...; Region: D-AAT_like; cd01558 637380004820 homodimer interface [polypeptide binding]; other site 637380004821 substrate-cofactor binding pocket; other site 637380004822 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380004823 catalytic residue [active] 637380004824 potential frameshift: common BLAST hit: gi|227815330|ref|YP_002815339.1| acetolactate synthase 3 catalytic subunit 637380004825 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 637380004826 PYR/PP interface [polypeptide binding]; other site 637380004827 dimer interface [polypeptide binding]; other site 637380004828 TPP binding site [chemical binding]; other site 637380004829 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637380004830 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637380004831 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 637380004832 TPP-binding site [chemical binding]; other site 637380004833 dimer interface [polypeptide binding]; other site 637380004834 ketol-acid reductoisomerase; Provisional; Region: PRK05479 637380004835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380004836 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 637380004837 Dehydratase family; Region: ILVD_EDD; cl00340 637380004838 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 637380004839 threonine dehydratase; Validated; Region: PRK08639 637380004840 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 637380004841 tetramer interface [polypeptide binding]; other site 637380004842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380004843 catalytic residue [active] 637380004844 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 637380004845 putative Ile/Val binding site [chemical binding]; other site 637380004846 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 637380004847 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 637380004848 putative active site [active] 637380004849 putative metal binding site [ion binding]; other site 637380004850 Protein of unknown function (DUF554); Region: DUF554; cl00784 637380004851 drug efflux system protein MdtG; Provisional; Region: PRK09874 637380004852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380004853 putative substrate translocation pore; other site 637380004854 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 637380004855 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 637380004856 putative active site [active] 637380004857 metal binding site [ion binding]; metal-binding site 637380004858 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 637380004859 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380004860 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 637380004861 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 637380004862 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 637380004863 LytTr DNA-binding domain; Region: LytTR; cl04498 637380004864 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 637380004865 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 637380004866 Coenzyme A transferase; Region: CoA_trans; cl00773 637380004867 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 637380004868 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 637380004869 active site 637380004870 putative substrate binding pocket [chemical binding]; other site 637380004871 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 637380004872 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380004873 ABC transporter signature motif; other site 637380004874 Walker B; other site 637380004875 D-loop; other site 637380004876 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 637380004877 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637380004878 peptide binding site [polypeptide binding]; other site 637380004879 Proteins of 100 residues with WXG; Region: WXG100; cl02005 637380004880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 637380004881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380004882 S-adenosylmethionine binding site [chemical binding]; other site 637380004883 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 637380004884 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 637380004885 FeS/SAM binding site; other site 637380004886 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 637380004887 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380004888 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380004889 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380004890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380004891 active site 637380004892 phosphorylation site [posttranslational modification] 637380004893 intermolecular recognition site; other site 637380004894 dimerization interface [polypeptide binding]; other site 637380004895 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380004896 DNA binding site [nucleotide binding] 637380004897 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637380004898 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637380004899 dimerization interface [polypeptide binding]; other site 637380004900 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380004901 dimer interface [polypeptide binding]; other site 637380004902 phosphorylation site [posttranslational modification] 637380004903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380004904 ATP binding site [chemical binding]; other site 637380004905 Mg2+ binding site [ion binding]; other site 637380004906 G-X-G motif; other site 637380004907 hypothetical protein; Provisional; Region: PRK12361 637380004908 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 637380004909 Peptidase family M23; Region: Peptidase_M23; pfam01551 637380004910 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 637380004911 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 637380004912 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 637380004913 active site residue [active] 637380004914 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 637380004915 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 637380004916 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380004917 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 637380004918 BACI_c18720; ydaO/yuaA leader, RF00379 637380004919 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380004920 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 637380004921 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 637380004922 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 637380004923 LysE type translocator; Region: LysE; cl00565 637380004924 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 637380004925 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 637380004926 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 637380004927 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 637380004928 intersubunit interface [polypeptide binding]; other site 637380004929 active site 637380004930 catalytic residue [active] 637380004931 nucleoside transporter; Region: nupC; TIGR00804 637380004932 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 637380004933 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 637380004934 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 637380004935 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 637380004936 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 637380004937 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 637380004938 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 637380004939 active site 637380004940 catalytic motif [active] 637380004941 Zn binding site [ion binding]; other site 637380004942 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 637380004943 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 637380004944 proline aminopeptidase P II; Provisional; Region: PRK10879 637380004945 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 637380004946 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087 637380004947 active site 637380004948 DNA topoisomerase III; Provisional; Region: PRK07726 637380004949 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362 637380004950 active site 637380004951 putative interdomain interaction site [polypeptide binding]; other site 637380004952 putative metal-binding site [ion binding]; other site 637380004953 putative nucleotide binding site [chemical binding]; other site 637380004954 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 637380004955 domain I; other site 637380004956 DNA binding groove [nucleotide binding] 637380004957 phosphate binding site [ion binding]; other site 637380004958 domain II; other site 637380004959 domain III; other site 637380004960 nucleotide binding site [chemical binding]; other site 637380004961 catalytic site [active] 637380004962 domain IV; other site 637380004963 DNA topoisomerase III; Validated; Region: PRK08173 637380004964 H+ Antiporter protein; Region: 2A0121; TIGR00900 637380004965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380004966 putative substrate translocation pore; other site 637380004967 Membrane transport protein; Region: Mem_trans; cl09117 637380004968 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 637380004969 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 637380004970 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 637380004971 dimer interface [polypeptide binding]; other site 637380004972 substrate binding site [chemical binding]; other site 637380004973 metal binding site [ion binding]; metal-binding site 637380004974 Copper resistance protein CopC; Region: CopC; cl01012 637380004975 Copper resistance protein D; Region: CopD; cl00563 637380004976 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 637380004977 EamA-like transporter family; Region: EamA; cl01037 637380004978 EamA-like transporter family; Region: EamA; cl01037 637380004979 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637380004980 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380004981 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637380004982 dimerization interface [polypeptide binding]; other site 637380004983 Predicted transcriptional regulator [Transcription]; Region: COG1959 637380004984 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380004985 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 637380004986 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 637380004987 catalytic residues [active] 637380004988 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 637380004989 dimer interface [polypeptide binding]; other site 637380004990 FMN binding site [chemical binding]; other site 637380004991 amidase; Provisional; Region: PRK06707 637380004992 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 637380004993 Domain of unknown function DUF20; Region: UPF0118; cl00465 637380004994 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 637380004995 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 637380004996 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637380004997 NAD binding site [chemical binding]; other site 637380004998 dimer interface [polypeptide binding]; other site 637380004999 substrate binding site [chemical binding]; other site 637380005000 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380005001 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 637380005002 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 637380005003 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 637380005004 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 637380005005 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 637380005006 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 637380005007 putative ligand binding site [chemical binding]; other site 637380005008 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 637380005009 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 637380005010 Walker A/P-loop; other site 637380005011 ATP binding site [chemical binding]; other site 637380005012 Q-loop/lid; other site 637380005013 ABC transporter signature motif; other site 637380005014 Walker B; other site 637380005015 D-loop; other site 637380005016 H-loop/switch region; other site 637380005017 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 637380005018 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 637380005019 Walker A/P-loop; other site 637380005020 ATP binding site [chemical binding]; other site 637380005021 Q-loop/lid; other site 637380005022 ABC transporter signature motif; other site 637380005023 Walker B; other site 637380005024 D-loop; other site 637380005025 H-loop/switch region; other site 637380005026 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 637380005027 TM-ABC transporter signature motif; other site 637380005028 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 637380005029 TM-ABC transporter signature motif; other site 637380005030 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380005031 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380005032 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 637380005033 Transcriptional regulators [Transcription]; Region: MarR; COG1846 637380005034 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380005035 CE1758 family; Region: LLM_CE1758_fam; TIGR04036 637380005036 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 637380005037 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 637380005038 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 637380005039 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 637380005040 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 637380005041 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637380005042 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380005043 Walker A/P-loop; other site 637380005044 ATP binding site [chemical binding]; other site 637380005045 Q-loop/lid; other site 637380005046 ABC transporter signature motif; other site 637380005047 Walker B; other site 637380005048 D-loop; other site 637380005049 H-loop/switch region; other site 637380005050 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 637380005051 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637380005052 The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247 637380005053 Walker A/P-loop; other site 637380005054 ATP binding site [chemical binding]; other site 637380005055 Q-loop/lid; other site 637380005056 ABC transporter signature motif; other site 637380005057 Walker B; other site 637380005058 D-loop; other site 637380005059 H-loop/switch region; other site 637380005060 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 637380005061 putative dimer interface [polypeptide binding]; other site 637380005062 catalytic triad [active] 637380005063 Beta-lactamase; Region: Beta-lactamase; cl01009 637380005064 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 637380005065 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 637380005066 dimer interface [polypeptide binding]; other site 637380005067 FMN binding site [chemical binding]; other site 637380005068 Bacterial SH3 domain; Region: SH3_3; cl02551 637380005069 Bacterial SH3 domain; Region: SH3_3; cl02551 637380005070 Bacterial SH3 domain; Region: SH3_3; cl02551 637380005071 NlpC/P60 family; Region: NLPC_P60; cl11438 637380005072 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637380005073 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637380005074 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637380005075 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380005076 Walker A/P-loop; other site 637380005077 ATP binding site [chemical binding]; other site 637380005078 Q-loop/lid; other site 637380005079 ABC transporter signature motif; other site 637380005080 Walker B; other site 637380005081 D-loop; other site 637380005082 H-loop/switch region; other site 637380005083 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380005084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380005085 active site 637380005086 phosphorylation site [posttranslational modification] 637380005087 intermolecular recognition site; other site 637380005088 dimerization interface [polypeptide binding]; other site 637380005089 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380005090 DNA binding site [nucleotide binding] 637380005091 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637380005092 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 637380005093 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380005094 dimer interface [polypeptide binding]; other site 637380005095 phosphorylation site [posttranslational modification] 637380005096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380005097 ATP binding site [chemical binding]; other site 637380005098 Mg2+ binding site [ion binding]; other site 637380005099 G-X-G motif; other site 637380005100 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 637380005101 classical (c) SDRs; Region: SDR_c; cd05233 637380005102 NAD(P) binding site [chemical binding]; other site 637380005103 active site 637380005104 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 637380005105 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 637380005106 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 637380005107 nudix motif; other site 637380005108 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 637380005109 homoserine dehydrogenase; Provisional; Region: PRK06349 637380005110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380005111 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 637380005112 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 637380005113 threonine synthase; Reviewed; Region: PRK06721 637380005114 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 637380005115 homodimer interface [polypeptide binding]; other site 637380005116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380005117 catalytic residue [active] 637380005118 homoserine kinase; Provisional; Region: PRK01212 637380005119 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 637380005120 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 637380005121 Protein of unknown function (DUF3111); Region: DUF3111; pfam11308 637380005122 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 637380005123 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380005124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380005125 active site 637380005126 phosphorylation site [posttranslational modification] 637380005127 intermolecular recognition site; other site 637380005128 dimerization interface [polypeptide binding]; other site 637380005129 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380005130 DNA binding site [nucleotide binding] 637380005131 sensory histidine kinase AtoS; Provisional; Region: PRK11360 637380005132 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637380005133 dimerization interface [polypeptide binding]; other site 637380005134 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380005135 dimer interface [polypeptide binding]; other site 637380005136 phosphorylation site [posttranslational modification] 637380005137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380005138 ATP binding site [chemical binding]; other site 637380005139 Mg2+ binding site [ion binding]; other site 637380005140 G-X-G motif; other site 637380005141 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 637380005142 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 637380005143 MgtC family; Region: MgtC; cl12207 637380005144 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 637380005145 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380005146 Coenzyme A binding pocket [chemical binding]; other site 637380005147 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 637380005148 IucA / IucC family; Region: IucA_IucC; pfam04183 637380005149 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 637380005150 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 637380005151 IucA / IucC family; Region: IucA_IucC; pfam04183 637380005152 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 637380005153 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 637380005154 Phosphopantetheine attachment site; Region: PP-binding; cl09936 637380005155 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 637380005156 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 637380005157 AP (apurinic/apyrimidinic) site pocket; other site 637380005158 DNA interaction; other site 637380005159 Metal-binding active site; metal-binding site 637380005160 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 637380005161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380005162 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637380005163 putative substrate translocation pore; other site 637380005164 LysE type translocator; Region: LysE; cl00565 637380005165 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 637380005166 active site 637380005167 nucleophile elbow; other site 637380005168 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 637380005169 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 637380005170 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 637380005171 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 637380005172 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 637380005173 nudix motif; other site 637380005174 NAD+ synthetase; Region: nadE; TIGR00552 637380005175 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 637380005176 homodimer interface [polypeptide binding]; other site 637380005177 NAD binding pocket [chemical binding]; other site 637380005178 ATP binding pocket [chemical binding]; other site 637380005179 Mg binding site [ion binding]; other site 637380005180 active-site loop [active] 637380005181 FtsX-like permease family; Region: FtsX; pfam02687 637380005182 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637380005183 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 637380005184 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 637380005185 active site 637380005186 catalytic residues [active] 637380005187 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380005188 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 637380005189 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 637380005190 active site 637380005191 catalytic tetrad [active] 637380005192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380005193 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 637380005194 putative substrate translocation pore; other site 637380005195 DinB superfamily; Region: DinB_2; cl00986 637380005196 GTPase RsgA; Reviewed; Region: PRK01889 637380005197 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 637380005198 GTPase/OB domain interface [polypeptide binding]; other site 637380005199 GTPase/Zn-binding domain interface [polypeptide binding]; other site 637380005200 GTP/Mg2+ binding site [chemical binding]; other site 637380005201 G4 box; other site 637380005202 G5 box; other site 637380005203 G1 box; other site 637380005204 Switch I region; other site 637380005205 G2 box; other site 637380005206 G3 box; other site 637380005207 Switch II region; other site 637380005208 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 637380005209 Cache domain; Region: Cache_1; pfam02743 637380005210 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 637380005211 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637380005212 dimerization interface [polypeptide binding]; other site 637380005213 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637380005214 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 637380005215 Uncharacterized membrane protein [Function unknown]; Region: COG3949 637380005216 Ferritin-like domain; Region: Ferritin; pfam00210 637380005217 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 637380005218 dimerization interface [polypeptide binding]; other site 637380005219 DPS ferroxidase diiron center [ion binding]; other site 637380005220 ion pore; other site 637380005221 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 637380005222 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 637380005223 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 637380005224 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380005225 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 637380005226 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380005227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380005228 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 637380005229 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637380005230 active site 637380005231 catalytic tetrad [active] 637380005232 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 637380005233 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 637380005234 P-loop, Walker A motif; other site 637380005235 Base recognition motif; other site 637380005236 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 637380005237 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380005238 Coenzyme A binding pocket [chemical binding]; other site 637380005239 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 637380005240 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 637380005241 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 637380005242 metal binding site [ion binding]; metal-binding site 637380005243 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 637380005244 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 637380005245 NAD binding site [chemical binding]; other site 637380005246 active site 637380005247 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 637380005248 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 637380005249 active site 637380005250 FMN binding site [chemical binding]; other site 637380005251 substrate binding site [chemical binding]; other site 637380005252 homotetramer interface [polypeptide binding]; other site 637380005253 catalytic residue [active] 637380005254 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 637380005255 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 637380005256 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 637380005257 DNA binding site [nucleotide binding] 637380005258 active site 637380005259 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 637380005260 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 637380005261 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637380005262 peptide binding site [polypeptide binding]; other site 637380005263 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 637380005264 active site 637380005265 metal binding site [ion binding]; metal-binding site 637380005266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380005267 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637380005268 catalytic core [active] 637380005269 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 637380005270 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 637380005271 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 637380005272 nudix motif; other site 637380005273 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 637380005274 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 637380005275 integral membrane protein MviN; Region: mviN; TIGR01695 637380005276 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 637380005277 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 637380005278 Predicted permease; Region: DUF318; cl00487 637380005279 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 637380005280 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 637380005281 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 637380005282 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 637380005283 putative active site [active] 637380005284 catalytic site [active] 637380005285 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 637380005286 putative active site [active] 637380005287 catalytic site [active] 637380005288 Coat F domain; Region: Coat_F; cl02368 637380005289 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 637380005290 NAD binding site [chemical binding]; other site 637380005291 substrate binding site [chemical binding]; other site 637380005292 putative active site [active] 637380005293 Protein of unknown function (DUF456); Region: DUF456; cl01069 637380005294 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 637380005295 Domain of unknown function DUF21; Region: DUF21; pfam01595 637380005296 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 637380005297 Transporter associated domain; Region: CorC_HlyC; pfam03471 637380005298 FOG: CBS domain [General function prediction only]; Region: COG0517 637380005299 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 637380005300 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 637380005301 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 637380005302 dimer interface [polypeptide binding]; other site 637380005303 putative tRNA-binding site [nucleotide binding]; other site 637380005304 DinB superfamily; Region: DinB_2; cl00986 637380005305 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 637380005306 stage II sporulation protein P; Region: spore_II_P; TIGR02867 637380005307 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 637380005308 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380005309 Coenzyme A binding pocket [chemical binding]; other site 637380005310 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380005311 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 637380005312 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 637380005313 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+ for their activity and contain a highly...; Region: Nudix_Hydrolase_6; cd04663 637380005314 nudix motif; other site 637380005315 amidase; Provisional; Region: PRK06828 637380005316 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 637380005317 H+ Antiporter protein; Region: 2A0121; TIGR00900 637380005318 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 637380005319 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 637380005320 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 637380005321 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637380005322 catalytic core [active] 637380005323 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637380005324 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637380005325 active site 637380005326 motif I; other site 637380005327 motif II; other site 637380005328 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637380005329 DinB superfamily; Region: DinB_2; cl00986 637380005330 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 637380005331 alanine racemase; Reviewed; Region: alr; PRK00053 637380005332 active site 637380005333 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637380005334 dimer interface [polypeptide binding]; other site 637380005335 substrate binding site [chemical binding]; other site 637380005336 catalytic residues [active] 637380005337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380005338 S-adenosylmethionine binding site [chemical binding]; other site 637380005339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380005340 Coenzyme A binding pocket [chemical binding]; other site 637380005341 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380005342 Coenzyme A binding pocket [chemical binding]; other site 637380005343 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 637380005344 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 637380005345 glycosyltransferase, MGT family; Region: MGT; TIGR01426 637380005346 active site 637380005347 TDP-binding site; other site 637380005348 acceptor substrate-binding pocket; other site 637380005349 homodimer interface [polypeptide binding]; other site 637380005350 Uncharacterized conserved protein [Function unknown]; Region: COG1284 637380005351 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637380005352 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 637380005353 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 637380005354 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637380005355 DNA-binding site [nucleotide binding]; DNA binding site 637380005356 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637380005357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380005358 homodimer interface [polypeptide binding]; other site 637380005359 catalytic residue [active] 637380005360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380005361 Coenzyme A binding pocket [chemical binding]; other site 637380005362 potential frameshift: common BLAST hit: gi|225864065|ref|YP_002749443.1| putative serine/threonine protein phosphatase 637380005363 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 637380005364 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637380005365 active site 637380005366 metal binding site [ion binding]; metal-binding site 637380005367 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 637380005368 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380005369 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380005370 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 637380005371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380005372 Coenzyme A binding pocket [chemical binding]; other site 637380005373 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380005374 Coenzyme A binding pocket [chemical binding]; other site 637380005375 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637380005376 active site 637380005377 ATP binding site [chemical binding]; other site 637380005378 substrate binding site [chemical binding]; other site 637380005379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 637380005380 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 637380005381 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 637380005382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380005383 S-adenosylmethionine binding site [chemical binding]; other site 637380005384 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 637380005385 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 637380005386 Potassium binding sites [ion binding]; other site 637380005387 Cesium cation binding sites [ion binding]; other site 637380005388 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 637380005389 DEAD-like helicases superfamily; Region: DEXDc; smart00487 637380005390 ATP binding site [chemical binding]; other site 637380005391 Mg++ binding site [ion binding]; other site 637380005392 motif III; other site 637380005393 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637380005394 nucleotide binding region [chemical binding]; other site 637380005395 ATP-binding site [chemical binding]; other site 637380005396 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 637380005397 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 637380005398 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 637380005399 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 637380005400 NADP binding site [chemical binding]; other site 637380005401 dimer interface [polypeptide binding]; other site 637380005402 RNA polymerase sigma factor; Provisional; Region: PRK12543 637380005403 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637380005404 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 637380005405 DNA binding residues [nucleotide binding] 637380005406 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 637380005407 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380005408 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 637380005409 catalytic residues [active] 637380005410 dimer interface [polypeptide binding]; other site 637380005411 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 637380005412 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 637380005413 Protein of unknown function DUF58; Region: DUF58; pfam01882 637380005414 MoxR-like ATPases [General function prediction only]; Region: COG0714 637380005415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380005416 Walker A motif; other site 637380005417 ATP binding site [chemical binding]; other site 637380005418 Walker B motif; other site 637380005419 arginine finger; other site 637380005420 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 637380005421 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate...; Region: MopB_Nitrate-R-NarG-like; cd02750 637380005422 [4Fe-4S] binding site [ion binding]; other site 637380005423 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 637380005424 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 637380005425 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 637380005426 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 637380005427 molybdopterin cofactor binding site; other site 637380005428 nitrate reductase, beta subunit; Region: narH; TIGR01660 637380005429 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 637380005430 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 637380005431 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 637380005432 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 637380005433 ligand binding site [chemical binding]; other site 637380005434 flexible hinge region; other site 637380005435 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 637380005436 putative switch regulator; other site 637380005437 non-specific DNA interactions [nucleotide binding]; other site 637380005438 DNA binding site [nucleotide binding] 637380005439 sequence specific DNA binding site [nucleotide binding]; other site 637380005440 putative cAMP binding site [chemical binding]; other site 637380005441 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 637380005442 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 637380005443 FeS/SAM binding site; other site 637380005444 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 637380005445 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 637380005446 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 637380005447 ATP binding site [chemical binding]; other site 637380005448 substrate interface [chemical binding]; other site 637380005449 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 637380005450 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 637380005451 dimer interface [polypeptide binding]; other site 637380005452 putative functional site; other site 637380005453 putative MPT binding site; other site 637380005454 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 637380005455 MoaE homodimer interface [polypeptide binding]; other site 637380005456 MoaD interaction [polypeptide binding]; other site 637380005457 active site residues [active] 637380005458 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 637380005459 MoaE interaction surface [polypeptide binding]; other site 637380005460 MoeB interaction surface [polypeptide binding]; other site 637380005461 thiocarboxylated glycine; other site 637380005462 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 637380005463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380005464 putative substrate translocation pore; other site 637380005465 Membrane transport protein; Region: Mem_trans; cl09117 637380005466 precorrin-2 dehydrogenase; Validated; Region: PRK06719 637380005467 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416 637380005468 putative active site [active] 637380005469 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_C; cd03414 637380005470 putative active site [active] 637380005471 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 637380005472 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 637380005473 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 637380005474 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 637380005475 [2Fe-2S] cluster binding site [ion binding]; other site 637380005476 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 637380005477 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380005478 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 637380005479 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 637380005480 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 637380005481 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 637380005482 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 637380005483 N-acetyltransferase; Region: Acetyltransf_2; cl00949 637380005484 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 637380005485 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380005486 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 637380005487 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 637380005488 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 637380005489 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 637380005490 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 637380005491 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380005492 Walker A/P-loop; other site 637380005493 ATP binding site [chemical binding]; other site 637380005494 Q-loop/lid; other site 637380005495 ABC transporter signature motif; other site 637380005496 Walker B; other site 637380005497 D-loop; other site 637380005498 H-loop/switch region; other site 637380005499 ABC transporter; Region: ABC_tran_2; pfam12848 637380005500 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637380005501 BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cl00473 637380005502 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 637380005503 dimer interface [polypeptide binding]; other site 637380005504 ssDNA binding site [nucleotide binding]; other site 637380005505 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637380005506 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 637380005507 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 637380005508 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 637380005509 Protein of unknown function, DUF393; Region: DUF393; cl01136 637380005510 Protein of unknown function (DUF1094); Region: DUF1094; pfam06491 637380005511 Brix domain; Region: Brix; cl00935 637380005512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380005513 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 637380005514 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 637380005515 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 637380005516 active site 637380005517 HIGH motif; other site 637380005518 KMSK motif region; other site 637380005519 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 637380005520 tRNA binding surface [nucleotide binding]; other site 637380005521 anticodon binding site; other site 637380005522 Predicted membrane protein (DUF2085); Region: DUF2085; cl01570 637380005523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380005524 hypothetical protein; Provisional; Region: PRK08317 637380005525 potential frameshift: common BLAST hit: gi|225864162|ref|YP_002749540.1| tetratricopeptide repeat protein 637380005526 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 637380005527 putative active site [active] 637380005528 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637380005529 binding surface 637380005530 TPR motif; other site 637380005531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637380005532 binding surface 637380005533 TPR motif; other site 637380005534 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 637380005535 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637380005536 binding surface 637380005537 TPR motif; other site 637380005538 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637380005539 binding surface 637380005540 TPR motif; other site 637380005541 isoleucyl-tRNA synthetase; Region: ileS; TIGR00392 637380005542 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 637380005543 HIGH motif; other site 637380005544 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 637380005545 active site 637380005546 KMSKS motif; other site 637380005547 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 637380005548 tRNA binding surface [nucleotide binding]; other site 637380005549 anticodon binding site; other site 637380005550 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 637380005551 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 637380005552 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 637380005553 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 637380005554 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 637380005555 Zn binding site [ion binding]; other site 637380005556 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 637380005557 Rhodopirellula transposase; Region: DDE_Tnp_ISAZ013; pfam07592 637380005558 Integrase core domain; Region: rve; cl01316 637380005559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637380005560 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 637380005561 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 637380005562 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637380005563 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 637380005564 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 637380005565 Dimer interface [polypeptide binding]; other site 637380005566 anticodon binding site; other site 637380005567 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776 637380005568 homodimer interface [polypeptide binding]; other site 637380005569 motif 1; other site 637380005570 motif 2; other site 637380005571 active site 637380005572 motif 3; other site 637380005573 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 637380005574 metal ion-dependent adhesion site (MIDAS); other site 637380005575 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 637380005576 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380005577 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380005578 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380005579 Proteins of 100 residues with WXG; Region: WXG100; cl02005 637380005580 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637380005581 active site 637380005582 ATP binding site [chemical binding]; other site 637380005583 substrate binding site [chemical binding]; other site 637380005584 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637380005585 binding surface 637380005586 TPR motif; other site 637380005587 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637380005588 binding surface 637380005589 TPR motif; other site 637380005590 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637380005591 binding surface 637380005592 TPR motif; other site 637380005593 potential frameshift: common BLAST hit: gi|218903328|ref|YP_002451162.1| group-specific protein 637380005594 SseB protein; Region: SseB; cl06279 637380005595 Proteins of 100 residues with WXG; Region: WXG100; cl02005 637380005596 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 637380005597 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 637380005598 catalytic residues [active] 637380005599 catalytic nucleophile [active] 637380005600 Recombinase; Region: Recombinase; pfam07508 637380005601 Uncharacterized conserved protein [Function unknown]; Region: COG5444 637380005602 Protein of unknown function, DUF600; Region: DUF600; cl04640 637380005603 Glycerate kinase family; Region: Gly_kinase; cl00841 637380005604 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 637380005605 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380005606 transmembrane helices; other site 637380005607 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380005608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380005609 active site 637380005610 phosphorylation site [posttranslational modification] 637380005611 intermolecular recognition site; other site 637380005612 dimerization interface [polypeptide binding]; other site 637380005613 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380005614 DNA binding site [nucleotide binding] 637380005615 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637380005616 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 637380005617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380005618 dimer interface [polypeptide binding]; other site 637380005619 phosphorylation site [posttranslational modification] 637380005620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380005621 ATP binding site [chemical binding]; other site 637380005622 Mg2+ binding site [ion binding]; other site 637380005623 G-X-G motif; other site 637380005624 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 637380005625 Predicted membrane protein [Function unknown]; Region: COG3212 637380005626 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 637380005627 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 637380005628 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637380005629 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 637380005630 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 637380005631 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 637380005632 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637380005633 motif II; other site 637380005634 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637380005635 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380005636 Citrate transporter; Region: CitMHS; pfam03600 637380005637 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 637380005638 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 637380005639 active site 637380005640 NAD binding site [chemical binding]; other site 637380005641 metal binding site [ion binding]; metal-binding site 637380005642 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 637380005643 aspartate racemase; Region: asp_race; TIGR00035 637380005644 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 637380005645 homodimer interaction site [polypeptide binding]; other site 637380005646 cofactor binding site; other site 637380005647 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637380005648 active site 637380005649 motif I; other site 637380005650 motif II; other site 637380005651 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 637380005652 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380005653 Coenzyme A binding pocket [chemical binding]; other site 637380005654 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 637380005655 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 637380005656 Walker A/P-loop; other site 637380005657 ATP binding site [chemical binding]; other site 637380005658 Q-loop/lid; other site 637380005659 ABC transporter signature motif; other site 637380005660 Walker B; other site 637380005661 D-loop; other site 637380005662 H-loop/switch region; other site 637380005663 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 637380005664 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 637380005665 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637380005666 motif II; other site 637380005667 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 637380005668 active site 637380005669 metal binding site [ion binding]; metal-binding site 637380005670 Phosphotransferase enzyme family; Region: APH; pfam01636 637380005671 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 637380005672 active site 637380005673 ATP binding site [chemical binding]; other site 637380005674 substrate binding site [chemical binding]; other site 637380005675 Beta-lactamase; Region: Beta-lactamase; cl01009 637380005676 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 637380005677 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 637380005678 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 637380005679 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 637380005680 dimerization interface [polypeptide binding]; other site 637380005681 active site 637380005682 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 637380005683 folate binding site [chemical binding]; other site 637380005684 NADP+ binding site [chemical binding]; other site 637380005685 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 637380005686 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637380005687 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 637380005688 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 637380005689 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 637380005690 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 637380005691 putative acyl-acceptor binding pocket; other site 637380005692 Haemolysin-III related; Region: HlyIII; cl03831 637380005693 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 637380005694 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 637380005695 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 637380005696 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 637380005697 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380005698 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 637380005699 Cu(I) binding site [ion binding]; other site 637380005700 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 637380005701 putative dimer interface [polypeptide binding]; other site 637380005702 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 637380005703 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 637380005704 active site 637380005705 dimer interface [polypeptide binding]; other site 637380005706 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 637380005707 Ligand Binding Site [chemical binding]; other site 637380005708 Molecular Tunnel; other site 637380005709 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380005710 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 637380005711 active site 637380005712 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 637380005713 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 637380005714 siderophore binding site; other site 637380005715 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-...; Region: D-AAT_like; cd01558 637380005716 homodimer interface [polypeptide binding]; other site 637380005717 substrate-cofactor binding pocket; other site 637380005718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380005719 Aminotransferase class IV; Region: Aminotran_4; pfam01063 637380005720 catalytic residue [active] 637380005721 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 637380005722 FMN binding site [chemical binding]; other site 637380005723 dimer interface [polypeptide binding]; other site 637380005724 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 637380005725 catalytic triad [active] 637380005726 conserved cis-peptide bond; other site 637380005727 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 637380005728 catalytic triad [active] 637380005729 conserved cis-peptide bond; other site 637380005730 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 637380005731 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 637380005732 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 637380005733 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 637380005734 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 637380005735 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 637380005736 DNA binding site [nucleotide binding] 637380005737 Int/Topo IB signature motif; other site 637380005738 active site 637380005739 catalytic residues [active] 637380005740 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 637380005741 nudix motif; other site 637380005742 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 637380005743 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 637380005744 putative dimer interface [polypeptide binding]; other site 637380005745 Mechanosensitive ion channel; Region: MS_channel; pfam00924 637380005746 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 637380005747 GAF domain; Region: GAF; cl00853 637380005748 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 637380005749 Histidine kinase; Region: HisKA_3; pfam07730 637380005750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380005751 ATP binding site [chemical binding]; other site 637380005752 Mg2+ binding site [ion binding]; other site 637380005753 G-X-G motif; other site 637380005754 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637380005755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380005756 active site 637380005757 phosphorylation site [posttranslational modification] 637380005758 intermolecular recognition site; other site 637380005759 dimerization interface [polypeptide binding]; other site 637380005760 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 637380005761 DNA binding residues [nucleotide binding] 637380005762 dimerization interface [polypeptide binding]; other site 637380005763 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 637380005764 putative active site [active] 637380005765 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 637380005766 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 637380005767 NAD binding site [chemical binding]; other site 637380005768 substrate binding site [chemical binding]; other site 637380005769 catalytic Zn binding site [ion binding]; other site 637380005770 tetramer interface [polypeptide binding]; other site 637380005771 structural Zn binding site [ion binding]; other site 637380005772 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 637380005773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380005774 dimer interface [polypeptide binding]; other site 637380005775 conserved gate region; other site 637380005776 ABC-ATPase subunit interface; other site 637380005777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 637380005778 Beta-lactamase; Region: Beta-lactamase; cl01009 637380005779 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 637380005780 Erythromycin esterase; Region: Erythro_esteras; pfam05139 637380005781 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 637380005782 active site 637380005783 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 637380005784 M28, and M42; Region: Zinc_peptidase_like; cl14876 637380005785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380005786 H+ Antiporter protein; Region: 2A0121; TIGR00900 637380005787 putative substrate translocation pore; other site 637380005788 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 637380005789 putative active site [active] 637380005790 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 637380005791 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 637380005792 Walker A/P-loop; other site 637380005793 ATP binding site [chemical binding]; other site 637380005794 Q-loop/lid; other site 637380005795 ABC transporter signature motif; other site 637380005796 Walker B; other site 637380005797 D-loop; other site 637380005798 H-loop/switch region; other site 637380005799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380005800 dimer interface [polypeptide binding]; other site 637380005801 conserved gate region; other site 637380005802 ABC-ATPase subunit interface; other site 637380005803 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380005804 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 637380005805 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380005806 MoxR-like ATPases [General function prediction only]; Region: COG0714 637380005807 Protein of unknown function (DUF524); Region: DUF524; pfam04411 637380005808 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 637380005809 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 637380005810 Domain of unknown function DUF21; Region: DUF21; pfam01595 637380005811 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 637380005812 Transporter associated domain; Region: CorC_HlyC; pfam03471 637380005813 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 637380005814 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 637380005815 NAD(P) binding site [chemical binding]; other site 637380005816 catalytic residues [active] 637380005817 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 637380005818 Histidine kinase N terminal; Region: HisK_N; pfam09385 637380005819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380005820 dimer interface [polypeptide binding]; other site 637380005821 phosphorylation site [posttranslational modification] 637380005822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380005823 ATP binding site [chemical binding]; other site 637380005824 Mg2+ binding site [ion binding]; other site 637380005825 G-X-G motif; other site 637380005826 hypothetical protein; Provisional; Region: PRK06917 637380005827 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 637380005828 inhibitor-cofactor binding pocket; inhibition site 637380005829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380005830 catalytic residue [active] 637380005831 Coenzyme A transferase; Region: CoA_trans; cl00773 637380005832 Coenzyme A transferase; Region: CoA_trans; cl00773 637380005833 acetylornithine deacetylase; Validated; Region: PRK06915 637380005834 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 637380005835 metal binding site [ion binding]; metal-binding site 637380005836 dimer interface [polypeptide binding]; other site 637380005837 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 637380005838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380005839 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 637380005840 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380005841 Walker A motif; other site 637380005842 ATP binding site [chemical binding]; other site 637380005843 Walker B motif; other site 637380005844 arginine finger; other site 637380005845 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 637380005846 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 637380005847 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 637380005848 FeS/SAM binding site; other site 637380005849 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 637380005850 uncharacterized protein, YokU family; Region: YokU_near_AblA; TIGR03829 637380005851 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 637380005852 Catalytic domain of Protein Kinases; Region: PKc; cd00180 637380005853 active site 637380005854 ATP binding site [chemical binding]; other site 637380005855 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 637380005856 substrate binding site [chemical binding]; other site 637380005857 activation loop (A-loop); other site 637380005858 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 637380005859 SpoOM protein; Region: Spo0M; pfam07070 637380005860 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 637380005861 active site 637380005862 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 637380005863 Cation efflux family; Region: Cation_efflux; cl00316 637380005864 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 637380005865 catalytic residues [active] 637380005866 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 637380005867 homotrimer interaction site [polypeptide binding]; other site 637380005868 putative active site [active] 637380005869 CHRD domain; Region: CHRD; cl06473 637380005870 C1q domain; Region: C1q; cl02466 637380005871 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 637380005872 PPIC-type PPIASE domain; Region: Rotamase; cl08278 637380005873 YolD-like protein; Region: YolD; pfam08863 637380005874 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 637380005875 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 637380005876 classical (c) SDRs; Region: SDR_c; cd05233 637380005877 NAD(P) binding site [chemical binding]; other site 637380005878 active site 637380005879 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 637380005880 Transglycosylase; Region: Transgly; cl07896 637380005881 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 637380005882 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 637380005883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380005884 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637380005885 putative substrate translocation pore; other site 637380005886 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 637380005887 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the...; Region: citrate_synt_like_1; cd06118 637380005888 dimer interface [polypeptide binding]; other site 637380005889 Citrate synthase; Region: Citrate_synt; pfam00285 637380005890 active site 637380005891 coenzyme A binding site [chemical binding]; other site 637380005892 citrylCoA binding site [chemical binding]; other site 637380005893 oxalacetate/citrate binding site [chemical binding]; other site 637380005894 catalytic triad [active] 637380005895 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 637380005896 2-methylcitrate dehydratase; Region: prpD; TIGR02330 637380005897 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 637380005898 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 637380005899 tetramer interface [polypeptide binding]; other site 637380005900 active site 637380005901 Mg2+/Mn2+ binding site [ion binding]; other site 637380005902 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 637380005903 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 637380005904 active site 637380005905 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 637380005906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380005907 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 637380005908 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 637380005909 tetrameric interface [polypeptide binding]; other site 637380005910 NAD binding site [chemical binding]; other site 637380005911 catalytic residues [active] 637380005912 LysE type translocator; Region: LysE; cl00565 637380005913 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 637380005914 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 637380005915 substrate binding site [chemical binding]; other site 637380005916 oxyanion hole (OAH) forming residues; other site 637380005917 trimer interface [polypeptide binding]; other site 637380005918 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 637380005919 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 637380005920 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 637380005921 active site 637380005922 metal binding site [ion binding]; metal-binding site 637380005923 DNA binding site [nucleotide binding] 637380005924 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 637380005925 exonuclease SbcC; Region: sbcc; TIGR00618 637380005926 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 637380005927 Walker A/P-loop; other site 637380005928 ATP binding site [chemical binding]; other site 637380005929 Q-loop/lid; other site 637380005930 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 637380005931 ABC transporter signature motif; other site 637380005932 Walker B; other site 637380005933 D-loop; other site 637380005934 H-loop/switch region; other site 637380005935 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637380005936 dimerization interface [polypeptide binding]; other site 637380005937 putative DNA binding site [nucleotide binding]; other site 637380005938 putative Zn2+ binding site [ion binding]; other site 637380005939 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 637380005940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380005941 putative substrate translocation pore; other site 637380005942 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 637380005943 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 637380005944 putative NAD(P) binding site [chemical binding]; other site 637380005945 active site 637380005946 isochorismate synthase DhbC; Validated; Region: PRK06923 637380005947 chorismate binding enzyme; Region: Chorismate_bind; cl10555 637380005948 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 637380005949 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 637380005950 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in...; Region: isochorismatase; cd01013 637380005951 hydrophobic substrate binding pocket; other site 637380005952 Isochorismatase family; Region: Isochorismatase; pfam00857 637380005953 active site 637380005954 conserved cis-peptide bond; other site 637380005955 Phosphopantetheine attachment site; Region: PP-binding; cl09936 637380005956 Condensation domain; Region: Condensation; cl09290 637380005957 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 637380005958 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 637380005959 Phosphopantetheine attachment site; Region: PP-binding; cl09936 637380005960 peptide synthase; Provisional; Region: PRK12467 637380005961 Condensation domain; Region: Condensation; cl09290 637380005962 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 637380005963 Phosphopantetheine attachment site; Region: PP-binding; cl09936 637380005964 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 637380005965 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380005966 MbtH-like protein; Region: MbtH; cl01279 637380005967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380005968 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637380005969 putative substrate translocation pore; other site 637380005970 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 637380005971 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 637380005972 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 637380005973 IHF dimer interface [polypeptide binding]; other site 637380005974 IHF - DNA interface [nucleotide binding]; other site 637380005975 DinB superfamily; Region: DinB_2; cl00986 637380005976 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 637380005977 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 637380005978 active site 637380005979 catalytic triad [active] 637380005980 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 637380005981 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 637380005982 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 637380005983 PseudoU_synth_RluF_like: Pseudouridine synthase, Escherichia coli RluF like. This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluF; cd02554 637380005984 probable active site [active] 637380005985 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 637380005986 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 637380005987 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 637380005988 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 637380005989 active site 637380005990 dimer interface [polypeptide binding]; other site 637380005991 motif 1; other site 637380005992 motif 2; other site 637380005993 motif 3; other site 637380005994 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 637380005995 anticodon binding site; other site 637380005996 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637380005997 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637380005998 Walker A/P-loop; other site 637380005999 ATP binding site [chemical binding]; other site 637380006000 Q-loop/lid; other site 637380006001 ABC transporter signature motif; other site 637380006002 Walker B; other site 637380006003 D-loop; other site 637380006004 H-loop/switch region; other site 637380006005 potential frameshift: common BLAST hit: gi|118477790|ref|YP_894941.1| ABC transporter, permease component 637380006006 FtsX-like permease family; Region: FtsX; pfam02687 637380006007 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 637380006008 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380006009 H+ Antiporter protein; Region: 2A0121; TIGR00900 637380006010 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637380006011 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 637380006012 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 637380006013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 637380006014 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 637380006015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380006016 S-adenosylmethionine binding site [chemical binding]; other site 637380006017 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; cl01543 637380006018 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 637380006019 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380006020 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base...; Region: nuc_hydro_TvIAG; cd02647 637380006021 active site 637380006022 dimerization interface [polypeptide binding]; other site 637380006023 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 637380006024 Protein of unknown function, DUF606; Region: DUF606; cl01273 637380006025 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 637380006026 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 637380006027 ligand binding site [chemical binding]; other site 637380006028 flexible hinge region; other site 637380006029 Protein of unknown function, DUF606; Region: DUF606; cl01273 637380006030 potential frameshift: common BLAST hit: gi|222095988|ref|YP_002530045.1| ribosomal-protein-alanine acetyltransferase 637380006031 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380006032 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380006033 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380006034 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 637380006035 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 637380006036 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 637380006037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380006038 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 637380006039 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380006040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380006041 Coenzyme A binding pocket [chemical binding]; other site 637380006042 EamA-like transporter family; Region: EamA; cl01037 637380006043 EamA-like transporter family; Region: EamA; cl01037 637380006044 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 637380006045 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380006046 non-specific DNA binding site [nucleotide binding]; other site 637380006047 salt bridge; other site 637380006048 sequence-specific DNA binding site [nucleotide binding]; other site 637380006049 Cupin domain; Region: Cupin_2; cl09118 637380006050 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 637380006051 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637380006052 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380006053 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380006054 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 637380006055 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380006056 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380006057 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 637380006058 DNA-binding site [nucleotide binding]; DNA binding site 637380006059 RNA-binding motif; other site 637380006060 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 637380006061 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380006062 Active site [active] 637380006063 Arginase family; Region: Arginase; cl00306 637380006064 hypothetical protein; Provisional; Region: PRK06770 637380006065 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637380006066 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380006067 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637380006068 dimerization interface [polypeptide binding]; other site 637380006069 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 637380006070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380006071 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 637380006072 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 637380006073 active site 637380006074 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 637380006075 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 637380006076 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380006077 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637380006078 dimerization interface [polypeptide binding]; other site 637380006079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 637380006080 MOSC domain; Region: MOSC; pfam03473 637380006081 3-alpha domain; Region: 3-alpha; pfam03475 637380006082 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 637380006083 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380006084 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 637380006085 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637380006086 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637380006087 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380006088 Walker A/P-loop; other site 637380006089 ATP binding site [chemical binding]; other site 637380006090 Q-loop/lid; other site 637380006091 ABC transporter signature motif; other site 637380006092 Walker B; other site 637380006093 D-loop; other site 637380006094 H-loop/switch region; other site 637380006095 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637380006096 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637380006097 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 637380006098 Walker A/P-loop; other site 637380006099 ATP binding site [chemical binding]; other site 637380006100 Q-loop/lid; other site 637380006101 ABC transporter signature motif; other site 637380006102 Walker B; other site 637380006103 D-loop; other site 637380006104 H-loop/switch region; other site 637380006105 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 637380006106 active site 637380006107 metal binding site [ion binding]; metal-binding site 637380006108 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 637380006109 LysE type translocator; Region: LysE; cl00565 637380006110 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 637380006111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380006112 non-specific DNA binding site [nucleotide binding]; other site 637380006113 salt bridge; other site 637380006114 sequence-specific DNA binding site [nucleotide binding]; other site 637380006115 Cupin domain; Region: Cupin_2; cl09118 637380006116 BclB C-terminal domain; Region: exospore_TM; TIGR03721 637380006117 Cupin domain; Region: Cupin_2; cl09118 637380006118 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 637380006119 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 637380006120 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 637380006121 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 637380006122 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 637380006123 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380006124 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 637380006125 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637380006126 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 637380006127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380006128 S-adenosylmethionine binding site [chemical binding]; other site 637380006129 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 637380006130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 637380006131 Uncharacterised BCR, COG1649; Region: DUF187; pfam02638 637380006132 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 637380006133 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637380006134 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 637380006135 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 637380006136 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 637380006137 Domain of unknown function (DUF205); Region: DUF205; cl00410 637380006138 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637380006139 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637380006140 catalytic residue [active] 637380006141 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 637380006142 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 637380006143 tetramer interface [polypeptide binding]; other site 637380006144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380006145 catalytic residue [active] 637380006146 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 637380006147 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380006148 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 637380006149 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 637380006150 ATP binding site [chemical binding]; other site 637380006151 Mg++ binding site [ion binding]; other site 637380006152 motif III; other site 637380006153 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637380006154 nucleotide binding region [chemical binding]; other site 637380006155 ATP-binding site [chemical binding]; other site 637380006156 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380006157 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380006158 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380006159 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 637380006160 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 637380006161 DNA binding site [nucleotide binding] 637380006162 Int/Topo IB signature motif; other site 637380006163 active site 637380006164 H+ Antiporter protein; Region: 2A0121; TIGR00900 637380006165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 637380006166 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 637380006167 FtsX-like permease family; Region: FtsX; pfam02687 637380006168 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637380006169 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637380006170 Walker A/P-loop; other site 637380006171 ATP binding site [chemical binding]; other site 637380006172 Q-loop/lid; other site 637380006173 ABC transporter signature motif; other site 637380006174 Walker B; other site 637380006175 D-loop; other site 637380006176 H-loop/switch region; other site 637380006177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380006178 S-adenosylmethionine binding site [chemical binding]; other site 637380006179 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 637380006180 dimer interface [polypeptide binding]; other site 637380006181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380006182 S-adenosylmethionine binding site [chemical binding]; other site 637380006183 cell division protein FtsZ; Region: ftsZ; TIGR00065 637380006184 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 637380006185 Phage integrase family; Region: Phage_integrase; pfam00589 637380006186 Int/Topo IB signature motif; other site 637380006187 C1q domain; Region: C1q; cl02466 637380006188 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 637380006189 Phage Terminase; Region: Terminase_1; pfam03354 637380006190 Cytochrome P450; Region: p450; cl12078 637380006191 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 637380006192 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637380006193 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380006194 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637380006195 catalytic core [active] 637380006196 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 637380006197 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 637380006198 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 637380006199 aminoacyl-histidine dipeptidase; Region: aa-his-dipept; TIGR01893 637380006200 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 637380006201 metal binding site [ion binding]; metal-binding site 637380006202 dimer interface [polypeptide binding]; other site 637380006203 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 637380006204 Rhodopirellula transposase; Region: DDE_Tnp_ISAZ013; pfam07592 637380006205 Integrase core domain; Region: rve; cl01316 637380006206 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637380006207 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 637380006208 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 637380006209 trimer interface [polypeptide binding]; other site 637380006210 active site 637380006211 substrate binding site [chemical binding]; other site 637380006212 CoA binding site [chemical binding]; other site 637380006213 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 637380006214 active site 637380006215 catalytic triad [active] 637380006216 oxyanion hole [active] 637380006217 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 637380006218 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637380006219 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 637380006220 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 637380006221 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 637380006222 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637380006223 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 637380006224 DNA binding residues [nucleotide binding] 637380006225 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637380006226 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 637380006227 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 637380006228 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637380006229 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637380006230 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 637380006231 Beta-lactamase; Region: Beta-lactamase; cl01009 637380006232 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 637380006233 active site 637380006234 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637380006235 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637380006236 DNA binding site [nucleotide binding] 637380006237 domain linker motif; other site 637380006238 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 637380006239 ligand binding site [chemical binding]; other site 637380006240 dimerization interface [polypeptide binding]; other site 637380006241 polyol permease family; Region: 2A0118; TIGR00897 637380006242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380006243 putative substrate translocation pore; other site 637380006244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380006245 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637380006246 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 637380006247 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 637380006248 substrate binding site [chemical binding]; other site 637380006249 ATP binding site [chemical binding]; other site 637380006250 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 637380006251 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 637380006252 tetrameric interface [polypeptide binding]; other site 637380006253 NAD binding site [chemical binding]; other site 637380006254 catalytic residues [active] 637380006255 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 637380006256 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 637380006257 PYR/PP interface [polypeptide binding]; other site 637380006258 dimer interface [polypeptide binding]; other site 637380006259 TPP binding site [chemical binding]; other site 637380006260 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637380006261 TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 637380006262 TPP-binding site; other site 637380006263 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 637380006264 hypothetical protein; Provisional; Region: PRK08185 637380006265 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 637380006266 intersubunit interface [polypeptide binding]; other site 637380006267 active site 637380006268 zinc binding site [ion binding]; other site 637380006269 Na+ binding site [ion binding]; other site 637380006270 KduI/IolB family; Region: KduI; cl01508 637380006271 DinB superfamily; Region: DinB_2; cl00986 637380006272 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 637380006273 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 637380006274 active site 637380006275 metal binding site [ion binding]; metal-binding site 637380006276 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 637380006277 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380006278 non-specific DNA binding site [nucleotide binding]; other site 637380006279 salt bridge; other site 637380006280 sequence-specific DNA binding site [nucleotide binding]; other site 637380006281 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 637380006282 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 637380006283 S-layer homology domain; Region: SLH; pfam00395 637380006284 S-layer homology domain; Region: SLH; pfam00395 637380006285 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 637380006286 active site 637380006287 metal binding site [ion binding]; metal-binding site 637380006288 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 637380006289 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380006290 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380006291 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 637380006292 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637380006293 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637380006294 Nuclease-related domain; Region: NERD; pfam08378 637380006295 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 637380006296 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 637380006297 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380006298 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380006299 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 637380006300 Cache domain; Region: Cache_1; pfam02743 637380006301 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637380006302 dimerization interface [polypeptide binding]; other site 637380006303 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637380006304 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 637380006305 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 637380006306 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380006307 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 637380006308 active site residue [active] 637380006309 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 637380006310 active site residue [active] 637380006311 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 637380006312 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 637380006313 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380006314 Walker A/P-loop; other site 637380006315 ATP binding site [chemical binding]; other site 637380006316 Q-loop/lid; other site 637380006317 ABC transporter signature motif; other site 637380006318 Walker B; other site 637380006319 D-loop; other site 637380006320 H-loop/switch region; other site 637380006321 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 637380006322 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637380006323 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 637380006324 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380006325 Protein of unknown function (DUF523); Region: DUF523; cl00733 637380006326 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 637380006327 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 637380006328 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 637380006329 FAD binding site [chemical binding]; other site 637380006330 homotetramer interface [polypeptide binding]; other site 637380006331 substrate binding pocket [chemical binding]; other site 637380006332 catalytic base [active] 637380006333 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 637380006334 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 637380006335 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 637380006336 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 637380006337 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 637380006338 carboxyltransferase (CT) interaction site; other site 637380006339 biotinylation site [posttranslational modification]; other site 637380006340 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 637380006341 active site 637380006342 catalytic residues [active] 637380006343 metal binding site [ion binding]; metal-binding site 637380006344 enoyl-CoA hydratase; Provisional; Region: PRK07657 637380006345 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 637380006346 substrate binding site [chemical binding]; other site 637380006347 oxyanion hole (OAH) forming residues; other site 637380006348 trimer interface [polypeptide binding]; other site 637380006349 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 637380006350 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 637380006351 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 637380006352 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 637380006353 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 637380006354 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 637380006355 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380006356 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380006357 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 637380006358 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380006359 Active site [active] 637380006360 DinB superfamily; Region: DinB_2; cl00986 637380006361 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 637380006362 Beta-lactamase; Region: Beta-lactamase; cl01009 637380006363 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380006364 dimer interface [polypeptide binding]; other site 637380006365 phosphorylation site [posttranslational modification] 637380006366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380006367 ATP binding site [chemical binding]; other site 637380006368 Mg2+ binding site [ion binding]; other site 637380006369 G-X-G motif; other site 637380006370 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380006371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380006372 active site 637380006373 phosphorylation site [posttranslational modification] 637380006374 intermolecular recognition site; other site 637380006375 dimerization interface [polypeptide binding]; other site 637380006376 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380006377 DNA binding site [nucleotide binding] 637380006378 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 637380006379 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 637380006380 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 637380006381 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 637380006382 NAD binding site [chemical binding]; other site 637380006383 substrate binding site [chemical binding]; other site 637380006384 putative active site [active] 637380006385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380006386 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380006387 Coenzyme A binding pocket [chemical binding]; other site 637380006388 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 637380006389 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 637380006390 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 637380006391 active site 637380006392 Zn binding site [ion binding]; other site 637380006393 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 637380006394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380006395 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 637380006396 putative hydrophobic ligand binding site [chemical binding]; other site 637380006397 Transposase domain (DUF772); Region: DUF772; cl12084 637380006398 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380006399 excinuclease ABC, A subunit; Region: uvra; TIGR00630 637380006400 Walker A/P-loop; other site 637380006401 ATP binding site [chemical binding]; other site 637380006402 Predicted ATPase, RNase L inhibitor (RLI) homolog [General function prediction only]; Region: COG1245 637380006403 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380006404 ABC transporter signature motif; other site 637380006405 Walker B; other site 637380006406 D-loop; other site 637380006407 H-loop/switch region; other site 637380006408 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637380006409 The excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-...; Region: ABC_UvrA; cd03238 637380006410 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 637380006411 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380006412 Beta-lactamase; Region: Beta-lactamase; cl01009 637380006413 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 637380006414 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 637380006415 DNA binding residues [nucleotide binding] 637380006416 drug binding residues [chemical binding]; other site 637380006417 dimer interface [polypeptide binding]; other site 637380006418 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 637380006419 potential frameshift: common BLAST hit: gi|227814610|ref|YP_002814619.1| putative permease 637380006420 H+ Antiporter protein; Region: 2A0121; TIGR00900 637380006421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380006422 putative substrate translocation pore; other site 637380006423 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 637380006424 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 637380006425 metal binding site [ion binding]; metal-binding site 637380006426 Phosphotransferase enzyme family; Region: APH; pfam01636 637380006427 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637380006428 active site 637380006429 ATP binding site [chemical binding]; other site 637380006430 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637380006431 active site 637380006432 ATP binding site [chemical binding]; other site 637380006433 substrate binding site [chemical binding]; other site 637380006434 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 637380006435 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637380006436 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 637380006437 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 637380006438 active site 637380006439 Zn binding site [ion binding]; other site 637380006440 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 637380006441 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637380006442 DNA-binding site [nucleotide binding]; DNA binding site 637380006443 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637380006444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380006445 homodimer interface [polypeptide binding]; other site 637380006446 catalytic residue [active] 637380006447 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 637380006448 Predicted membrane protein (DUF2079); Region: DUF2079; cl01374 637380006449 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 637380006450 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 637380006451 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 637380006452 putative NAD(P) binding site [chemical binding]; other site 637380006453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380006454 S-adenosylmethionine binding site [chemical binding]; other site 637380006455 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 637380006456 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 637380006457 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637380006458 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637380006459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380006460 S-adenosylmethionine binding site [chemical binding]; other site 637380006461 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 637380006462 potential frameshift: common BLAST hit: gi|49477784|ref|YP_036701.1| lysine--tRNA ligase (lysyl-tRNA synthetase) 637380006463 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 637380006464 active site 637380006465 HIGH motif; other site 637380006466 nucleotide binding site [chemical binding]; other site 637380006467 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 637380006468 Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: CysS; COG0215 637380006469 active site 637380006470 KMSKS motif; other site 637380006471 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 637380006472 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 637380006473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 637380006474 Rhodopirellula transposase; Region: DDE_Tnp_ISAZ013; pfam07592 637380006475 Integrase core domain; Region: rve; cl01316 637380006476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637380006477 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 637380006478 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380006479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380006480 active site 637380006481 phosphorylation site [posttranslational modification] 637380006482 intermolecular recognition site; other site 637380006483 dimerization interface [polypeptide binding]; other site 637380006484 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380006485 DNA binding site [nucleotide binding] 637380006486 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637380006487 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 637380006488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380006489 ATP binding site [chemical binding]; other site 637380006490 Mg2+ binding site [ion binding]; other site 637380006491 G-X-G motif; other site 637380006492 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 637380006493 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637380006494 ABC transporter; Region: ABC_tran_2; pfam12848 637380006495 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637380006496 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380006497 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380006498 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 637380006499 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637380006500 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637380006501 Walker A/P-loop; other site 637380006502 ATP binding site [chemical binding]; other site 637380006503 Q-loop/lid; other site 637380006504 ABC transporter signature motif; other site 637380006505 Walker B; other site 637380006506 D-loop; other site 637380006507 H-loop/switch region; other site 637380006508 FtsX-like permease family; Region: FtsX; pfam02687 637380006509 hypothetical protein; Provisional; Region: PRK06760; cl11698 637380006510 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 637380006511 homoserine dehydrogenase; Validated; Region: PRK06813 637380006512 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380006513 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 637380006514 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 637380006515 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637380006516 DNA-binding site [nucleotide binding]; DNA binding site 637380006517 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637380006518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380006519 homodimer interface [polypeptide binding]; other site 637380006520 catalytic residue [active] 637380006521 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 637380006522 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 637380006523 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 637380006524 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 637380006525 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 637380006526 Protein of unknown function; Region: DUF3658; pfam12395 637380006527 Cytochrome P450; Region: p450; cl12078 637380006528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380006529 H+ Antiporter protein; Region: 2A0121; TIGR00900 637380006530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380006531 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 637380006532 trimer interface [polypeptide binding]; other site 637380006533 active site 637380006534 substrate binding site [chemical binding]; other site 637380006535 CoA binding site [chemical binding]; other site 637380006536 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 637380006537 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380006538 Cytochrome P450; Region: p450; cl12078 637380006539 Cysteine dioxygenase type I; Region: CDO_I; cl02350 637380006540 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637380006541 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637380006542 active site 637380006543 motif I; other site 637380006544 motif II; other site 637380006545 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637380006546 PAS domain S-box; Region: sensory_box; TIGR00229 637380006547 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 637380006548 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 637380006549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380006550 dimer interface [polypeptide binding]; other site 637380006551 phosphorylation site [posttranslational modification] 637380006552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380006553 ATP binding site [chemical binding]; other site 637380006554 Mg2+ binding site [ion binding]; other site 637380006555 G-X-G motif; other site 637380006556 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 637380006557 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637380006558 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637380006559 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 637380006560 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 637380006561 glycosyltransferase, MGT family; Region: MGT; TIGR01426 637380006562 active site 637380006563 TDP-binding site; other site 637380006564 acceptor substrate-binding pocket; other site 637380006565 homodimer interface [polypeptide binding]; other site 637380006566 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 637380006567 aspartate racemase; Region: asp_race; TIGR00035 637380006568 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 637380006569 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 637380006570 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 637380006571 Walker A/P-loop; other site 637380006572 ATP binding site [chemical binding]; other site 637380006573 Q-loop/lid; other site 637380006574 ABC transporter signature motif; other site 637380006575 Walker B; other site 637380006576 D-loop; other site 637380006577 H-loop/switch region; other site 637380006578 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 637380006579 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 637380006580 Walker A/P-loop; other site 637380006581 ATP binding site [chemical binding]; other site 637380006582 Q-loop/lid; other site 637380006583 ABC transporter signature motif; other site 637380006584 Walker B; other site 637380006585 D-loop; other site 637380006586 H-loop/switch region; other site 637380006587 Cobalt transport protein; Region: CbiQ; cl00463 637380006588 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 637380006589 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637380006590 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380006591 dimer interface [polypeptide binding]; other site 637380006592 phosphorylation site [posttranslational modification] 637380006593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380006594 ATP binding site [chemical binding]; other site 637380006595 Mg2+ binding site [ion binding]; other site 637380006596 G-X-G motif; other site 637380006597 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637380006598 active site 637380006599 ATP binding site [chemical binding]; other site 637380006600 substrate binding site [chemical binding]; other site 637380006601 activation loop (A-loop); other site 637380006602 Uncharacterised protein family (UPF0157); Region: UPF0157; cl00987 637380006603 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 637380006604 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 637380006605 NAD(P) binding site [chemical binding]; other site 637380006606 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 637380006607 active site 637380006608 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 637380006609 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637380006610 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 637380006611 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 637380006612 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 637380006613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380006614 H+ Antiporter protein; Region: 2A0121; TIGR00900 637380006615 putative substrate translocation pore; other site 637380006616 Beta-lactamase; Region: Beta-lactamase; cl01009 637380006617 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 637380006618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380006619 Coenzyme A binding pocket [chemical binding]; other site 637380006620 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 637380006621 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 637380006622 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 637380006623 conserved cys residue [active] 637380006624 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 637380006625 Predicted transcriptional regulator [Transcription]; Region: COG2378 637380006626 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380006627 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 637380006628 conserved cys residue [active] 637380006629 Beta-lactamase; Region: Beta-lactamase; cl01009 637380006630 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637380006631 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 637380006632 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777 637380006633 DNA binding residues [nucleotide binding] 637380006634 putative dimer interface [polypeptide binding]; other site 637380006635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380006636 H+ Antiporter protein; Region: 2A0121; TIGR00900 637380006637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380006638 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 637380006639 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380006640 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 637380006641 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 637380006642 active site 637380006643 catalytic site [active] 637380006644 metal binding site [ion binding]; metal-binding site 637380006645 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 637380006646 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637380006647 DNA-binding site [nucleotide binding]; DNA binding site 637380006648 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637380006649 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380006650 homodimer interface [polypeptide binding]; other site 637380006651 catalytic residue [active] 637380006652 EamA-like transporter family; Region: EamA; cl01037 637380006653 EamA-like transporter family; Region: EamA; cl01037 637380006654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380006655 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 637380006656 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 637380006657 nudix motif; other site 637380006658 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 637380006659 Beta-lactamase; Region: Beta-lactamase; cl01009 637380006660 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 637380006661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380006662 putative substrate translocation pore; other site 637380006663 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 637380006664 Cadmium resistance transporter; Region: Cad; cl04177 637380006665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380006666 Coenzyme A binding pocket [chemical binding]; other site 637380006667 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 637380006668 nudix motif; other site 637380006669 DNA polymerase III subunit beta; Validated; Region: PRK06673 637380006670 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 637380006671 putative DNA binding surface [nucleotide binding]; other site 637380006672 dimer interface [polypeptide binding]; other site 637380006673 beta-clamp/clamp loader binding surface; other site 637380006674 beta-clamp/translesion DNA polymerase binding surface; other site 637380006675 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 637380006676 putative active site [active] 637380006677 nucleotide binding site [chemical binding]; other site 637380006678 nudix motif; other site 637380006679 putative metal binding site [ion binding]; other site 637380006680 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380006681 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 637380006682 homotrimer interaction site [polypeptide binding]; other site 637380006683 putative active site [active] 637380006684 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 637380006685 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 637380006686 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 637380006687 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380006688 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 637380006689 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 637380006690 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 637380006691 active site 637380006692 nucleophile elbow; other site 637380006693 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 637380006694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380006695 DinB superfamily; Region: DinB_2; cl00986 637380006696 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380006697 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 637380006698 Bacitracin resistance protein BacA; Region: BacA; cl00858 637380006699 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 637380006700 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380006701 Coenzyme A binding pocket [chemical binding]; other site 637380006702 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637380006703 active site 637380006704 ATP binding site [chemical binding]; other site 637380006705 substrate binding site [chemical binding]; other site 637380006706 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 637380006707 nudix motif; other site 637380006708 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 637380006709 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 637380006710 Domain of unknown function (DU1801); Region: DUF1801; cl01838 637380006711 N-acetyltransferase; Region: Acetyltransf_2; cl00949 637380006712 MepB protein; Region: MepB; cl01985 637380006713 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 637380006714 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637380006715 motif II; other site 637380006716 DinB superfamily; Region: DinB_2; cl00986 637380006717 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 637380006718 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 637380006719 active site 637380006720 Bacterial pullanase-associated domain; Region: PUD; pfam03714 637380006721 pullulanase, type I; Region: pulA_typeI; TIGR02104 637380006722 Pullulanase domain N-terminus. Pullulanase (AKA dextrinase; alpha-dextrin endo-1,6-alpha glucosidase) is an enzyme with action similar to that of isoamylase; it cleaves 1,6-alpha-glucosidic linkages in pullulan, amylopectin, and glycogen, and in alpha-...; Region: Pullulanase_N_term; cd02860 637380006723 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 637380006724 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 637380006725 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 637380006726 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 637380006727 active site 637380006728 Zn binding site [ion binding]; other site 637380006729 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl11829 637380006730 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 637380006731 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637380006732 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 637380006733 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 637380006734 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 637380006735 SecY translocase; Region: SecY; pfam00344 637380006736 hypothetical protein; Validated; Region: PRK06672 637380006737 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 637380006738 EamA-like transporter family; Region: EamA; cl01037 637380006739 EamA-like transporter family; Region: EamA; cl01037 637380006740 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 637380006741 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637380006742 DNA-binding site [nucleotide binding]; DNA binding site 637380006743 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637380006744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380006745 homodimer interface [polypeptide binding]; other site 637380006746 catalytic residue [active] 637380006747 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 637380006748 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380006749 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 637380006750 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 637380006751 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380006752 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 637380006753 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 637380006754 germination protein YpeB; Region: spore_YpeB; TIGR02889 637380006755 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 637380006756 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 637380006757 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 637380006758 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 637380006759 Beta-lactamase; Region: Beta-lactamase; cl01009 637380006760 potential frameshift: common BLAST hit: gi|225864728|ref|YP_002750106.1| tryptophan 2,3-dioxygenase 637380006761 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 637380006762 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 637380006763 Putative cyclase; Region: Cyclase; cl00814 637380006764 kynureninase; Region: kynureninase; TIGR01814 637380006765 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637380006766 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637380006767 catalytic residue [active] 637380006768 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380006769 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380006770 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 637380006771 hydrophobic ligand binding site; other site 637380006772 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 637380006773 GAF domain; Region: GAF; cl00853 637380006774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380006775 Walker A motif; other site 637380006776 ATP binding site [chemical binding]; other site 637380006777 Walker B motif; other site 637380006778 arginine finger; other site 637380006779 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 637380006780 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380006781 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380006782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380006783 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 637380006784 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380006785 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 637380006786 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 637380006787 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380006788 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380006789 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 637380006790 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 637380006791 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 637380006792 E3 interaction surface; other site 637380006793 lipoyl attachment site [posttranslational modification]; other site 637380006794 e3 binding domain; Region: E3_binding; pfam02817 637380006795 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 637380006796 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 637380006797 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 637380006798 alpha subunit interface [polypeptide binding]; other site 637380006799 TPP binding site [chemical binding]; other site 637380006800 heterodimer interface [polypeptide binding]; other site 637380006801 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637380006802 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 637380006803 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 637380006804 tetramer interface [polypeptide binding]; other site 637380006805 TPP-binding site [chemical binding]; other site 637380006806 heterodimer interface [polypeptide binding]; other site 637380006807 phosphorylation loop region [posttranslational modification] 637380006808 DinB superfamily; Region: DinB_2; cl00986 637380006809 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 637380006810 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 637380006811 NADP binding site [chemical binding]; other site 637380006812 active site 637380006813 steroid binding site; other site 637380006814 Uncharacterised protein family (UPF0157); Region: UPF0157; cl00987 637380006815 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380006816 Active site [active] 637380006817 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 637380006818 nudix motif; other site 637380006819 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 637380006820 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 637380006821 nucleotide binding site/active site [active] 637380006822 HIT family signature motif; other site 637380006823 catalytic residue [active] 637380006824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380006825 dimer interface [polypeptide binding]; other site 637380006826 conserved gate region; other site 637380006827 putative PBP binding loops; other site 637380006828 ABC-ATPase subunit interface; other site 637380006829 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 637380006830 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 637380006831 Walker A/P-loop; other site 637380006832 ATP binding site [chemical binding]; other site 637380006833 Q-loop/lid; other site 637380006834 ABC transporter signature motif; other site 637380006835 Walker B; other site 637380006836 D-loop; other site 637380006837 H-loop/switch region; other site 637380006838 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 637380006839 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380006840 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 637380006841 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 637380006842 oligomer interface [polypeptide binding]; other site 637380006843 active site residues [active] 637380006844 RNA polymerase factor sigma-70; Validated; Region: PRK06704 637380006845 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637380006846 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 637380006847 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 637380006848 catalytic loop [active] 637380006849 iron binding site [ion binding]; other site 637380006850 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 637380006851 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637380006852 active site 637380006853 dimer interface [polypeptide binding]; other site 637380006854 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380006855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 637380006856 Chitin binding domain; Region: Chitin_bind_3; cl03871 637380006857 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 637380006858 Interdomain contacts; other site 637380006859 Cytokine receptor motif; other site 637380006860 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 637380006861 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 637380006862 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380006863 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 637380006864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380006865 S-adenosylmethionine binding site [chemical binding]; other site 637380006866 Protein of unknown function (DUF419); Region: DUF419; cl09948 637380006867 Protein of unknown function (DUF419); Region: DUF419; cl09948 637380006868 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380006869 S-layer homology domain; Region: SLH; pfam00395 637380006870 S-layer homology domain; Region: SLH; pfam00395 637380006871 S-layer homology domain; Region: SLH; pfam00395 637380006872 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380006873 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 637380006874 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 637380006875 Rhodopirellula transposase; Region: DDE_Tnp_ISAZ013; pfam07592 637380006876 Integrase core domain; Region: rve; cl01316 637380006877 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637380006878 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 637380006879 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required...; Region: GH25_PlyB-like; cd06523 637380006880 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 637380006881 active site 637380006882 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 637380006883 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380006884 Coenzyme A binding pocket [chemical binding]; other site 637380006885 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380006886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380006887 Coenzyme A binding pocket [chemical binding]; other site 637380006888 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380006889 Protein of unknown function (DUF952); Region: DUF952; cl01393 637380006890 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 637380006891 UvrD/REP helicase; Region: UvrD-helicase; cl14126 637380006892 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 637380006893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380006894 S-adenosylmethionine binding site [chemical binding]; other site 637380006895 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 637380006896 putative active site pocket [active] 637380006897 dimerization interface [polypeptide binding]; other site 637380006898 putative catalytic residue [active] 637380006899 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 637380006900 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637380006901 ATP binding site [chemical binding]; other site 637380006902 putative Mg++ binding site [ion binding]; other site 637380006903 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637380006904 nucleotide binding region [chemical binding]; other site 637380006905 ATP-binding site [chemical binding]; other site 637380006906 RQC domain; Region: RQC; pfam09382 637380006907 HRDC domain; Region: HRDC; cl02578 637380006908 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 637380006909 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 637380006910 active site 637380006911 Zn binding site [ion binding]; other site 637380006912 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 637380006913 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 637380006914 DHHA2 domain; Region: DHHA2; pfam02833 637380006915 Chitin binding domain; Region: Chitin_bind_3; cl03871 637380006916 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380006917 Coenzyme A binding pocket [chemical binding]; other site 637380006918 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380006919 BACI_c27920; putative PyrR binding site, RF00515 637380006920 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 637380006921 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 637380006922 potential frameshift: common BLAST hit: gi|227814357|ref|YP_002814366.1| aldehyde dehydrogenase (NAD) family protein 637380006923 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 637380006924 NAD(P) binding site [chemical binding]; other site 637380006925 catalytic residues [active] 637380006926 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 637380006927 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 637380006928 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 637380006929 inhibitor site; inhibition site 637380006930 active site 637380006931 dimer interface [polypeptide binding]; other site 637380006932 catalytic residue [active] 637380006933 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 637380006934 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 637380006935 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 637380006936 Proline racemase; Region: Pro_racemase; pfam05544 637380006937 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 637380006938 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 637380006939 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 637380006940 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380006941 Walker A motif; other site 637380006942 ATP binding site [chemical binding]; other site 637380006943 Walker B motif; other site 637380006944 arginine finger; other site 637380006945 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 637380006946 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 637380006947 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 637380006948 catalytic loop [active] 637380006949 iron binding site [ion binding]; other site 637380006950 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 637380006951 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380006952 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 637380006953 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 637380006954 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637380006955 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 637380006956 active site 637380006957 metal binding site [ion binding]; metal-binding site 637380006958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380006959 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 637380006960 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 637380006961 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 637380006962 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 637380006963 DinB superfamily; Region: DinB_2; cl00986 637380006964 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 637380006965 DltD N-terminal region; Region: DltD_N; pfam04915 637380006966 DltD central region; Region: DltD_M; pfam04918 637380006967 DltD C-terminal region; Region: DltD_C; pfam04914 637380006968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380006969 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 637380006970 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637380006971 peptide binding site [polypeptide binding]; other site 637380006972 NlpC/P60 family; Region: NLPC_P60; cl11438 637380006973 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism...; Region: L-Ala-DL-Glu_epimerase; cd03319 637380006974 o-succinylbenzoic acid (OSB) synthetase; Region: menC_lowGC/arch; TIGR01928 637380006975 active site 637380006976 Septum formation initiator; Region: DivIC; cl11433 637380006977 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 637380006978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380006979 S-adenosylmethionine binding site [chemical binding]; other site 637380006980 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 637380006981 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 637380006982 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 637380006983 PPIC-type PPIASE domain; Region: Rotamase; cl08278 637380006984 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637380006985 dimerization interface [polypeptide binding]; other site 637380006986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380006987 dimer interface [polypeptide binding]; other site 637380006988 phosphorylation site [posttranslational modification] 637380006989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380006990 ATP binding site [chemical binding]; other site 637380006991 Mg2+ binding site [ion binding]; other site 637380006992 G-X-G motif; other site 637380006993 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380006994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380006995 active site 637380006996 phosphorylation site [posttranslational modification] 637380006997 intermolecular recognition site; other site 637380006998 dimerization interface [polypeptide binding]; other site 637380006999 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380007000 DNA binding site [nucleotide binding] 637380007001 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380007002 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 637380007003 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637380007004 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 637380007005 5'-methylthioadenosine nucleosidase; Region: PLN02584 637380007006 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637380007007 Phosphotransferase enzyme family; Region: APH; pfam01636 637380007008 active site 637380007009 substrate binding site [chemical binding]; other site 637380007010 ATP binding site [chemical binding]; other site 637380007011 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 637380007012 Zn binding site [ion binding]; other site 637380007013 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 637380007014 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 637380007015 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 637380007016 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 637380007017 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380007018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380007019 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 637380007020 putative substrate translocation pore; other site 637380007021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380007022 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 637380007023 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 637380007024 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 637380007025 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 637380007026 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 637380007027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380007028 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637380007029 putative substrate translocation pore; other site 637380007030 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 637380007031 active site 637380007032 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637380007033 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 637380007034 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 637380007035 Rhodopirellula transposase; Region: DDE_Tnp_ISAZ013; pfam07592 637380007036 Integrase core domain; Region: rve; cl01316 637380007037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380007038 S-adenosylmethionine binding site [chemical binding]; other site 637380007039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380007040 putative substrate translocation pore; other site 637380007041 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637380007042 aspartate aminotransferase; Provisional; Region: PRK07681 637380007043 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637380007044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380007045 homodimer interface [polypeptide binding]; other site 637380007046 catalytic residue [active] 637380007047 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 637380007048 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 637380007049 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 637380007050 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 637380007051 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637380007052 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 637380007053 Walker A/P-loop; other site 637380007054 ATP binding site [chemical binding]; other site 637380007055 Q-loop/lid; other site 637380007056 ABC transporter signature motif; other site 637380007057 Walker B; other site 637380007058 D-loop; other site 637380007059 H-loop/switch region; other site 637380007060 Predicted transcriptional regulators [Transcription]; Region: COG1725 637380007061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637380007062 DNA-binding site [nucleotide binding]; DNA binding site 637380007063 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 637380007064 Domain of unknown function DUF20; Region: UPF0118; cl00465 637380007065 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 637380007066 active site 637380007067 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 637380007068 dimer interface [polypeptide binding]; other site 637380007069 non-prolyl cis peptide bond; other site 637380007070 insertion regions; other site 637380007071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 637380007072 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 637380007073 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 637380007074 substrate binding pocket [chemical binding]; other site 637380007075 membrane-bound complex binding site; other site 637380007076 hinge residues; other site 637380007077 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 637380007078 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 637380007079 Walker A/P-loop; other site 637380007080 ATP binding site [chemical binding]; other site 637380007081 Q-loop/lid; other site 637380007082 ABC transporter signature motif; other site 637380007083 Walker B; other site 637380007084 D-loop; other site 637380007085 H-loop/switch region; other site 637380007086 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380007087 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380007088 Protein of unknown function (DUF402); Region: DUF402; cl00979 637380007089 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X...; Region: Nudix_Hydrolase_25; cd04684 637380007090 nudix motif; other site 637380007091 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637380007092 binding surface 637380007093 TPR motif; other site 637380007094 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 637380007095 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 637380007096 Glutathionylspermidine synthase; Region: GSP_synth; cl00503 637380007097 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380007098 DinB superfamily; Region: DinB_2; cl00986 637380007099 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380007100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380007101 Coenzyme A binding pocket [chemical binding]; other site 637380007102 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380007103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380007104 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 637380007105 active site 637380007106 NTP binding site [chemical binding]; other site 637380007107 metal binding triad [ion binding]; metal-binding site 637380007108 antibiotic binding site [chemical binding]; other site 637380007109 A new structural DNA glycosylase; Region: AlkD_like; cd06561 637380007110 Active site [active] 637380007111 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 637380007112 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 637380007113 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 637380007114 Integral membrane protein TerC family; Region: TerC; cl10468 637380007115 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 637380007116 Sulfatase; Region: Sulfatase; cl10460 637380007117 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 637380007118 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380007119 Walker A/P-loop; other site 637380007120 ATP binding site [chemical binding]; other site 637380007121 Q-loop/lid; other site 637380007122 ABC transporter signature motif; other site 637380007123 Walker B; other site 637380007124 D-loop; other site 637380007125 H-loop/switch region; other site 637380007126 ABC transporter; Region: ABC_tran_2; pfam12848 637380007127 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637380007128 hypothetical protein; Provisional; Region: PRK06761 637380007129 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 637380007130 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 637380007131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380007132 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380007133 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 637380007134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380007135 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 637380007136 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 637380007137 hinge; other site 637380007138 active site 637380007139 prephenate dehydrogenase; Validated; Region: PRK06545 637380007140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380007141 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 637380007142 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 637380007143 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637380007144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380007145 homodimer interface [polypeptide binding]; other site 637380007146 catalytic residue [active] 637380007147 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 637380007148 Tetramer interface [polypeptide binding]; other site 637380007149 Active site [active] 637380007150 FMN-binding site [chemical binding]; other site 637380007151 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 637380007152 Chorismate mutase type II; Region: CM_2; cl00693 637380007153 NeuB family; Region: NeuB; cl00496 637380007154 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 637380007155 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 637380007156 Isochorismatase family; Region: Isochorismatase; pfam00857 637380007157 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 637380007158 catalytic triad [active] 637380007159 conserved cis-peptide bond; other site 637380007160 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380007161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380007162 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380007163 Bacterial SH3 domain; Region: SH3_3; cl02551 637380007164 Bacterial SH3 domain; Region: SH3_3; cl02551 637380007165 3D domain; Region: 3D; cl01439 637380007166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380007167 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380007168 Citrate transporter; Region: CitMHS; pfam03600 637380007169 enoyl-CoA hydratase; Provisional; Region: PRK06688 637380007170 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 637380007171 substrate binding site [chemical binding]; other site 637380007172 oxyanion hole (OAH) forming residues; other site 637380007173 trimer interface [polypeptide binding]; other site 637380007174 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 637380007175 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 637380007176 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 637380007177 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 637380007178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380007179 Walker A motif; other site 637380007180 ATP binding site [chemical binding]; other site 637380007181 Walker B motif; other site 637380007182 arginine finger; other site 637380007183 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 637380007184 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 637380007185 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 637380007186 Predicted dehydrogenase [General function prediction only]; Region: COG0579 637380007187 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 637380007188 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 637380007189 ligand binding site [chemical binding]; other site 637380007190 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637380007191 TM-ABC transporter signature motif; other site 637380007192 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637380007193 TM-ABC transporter signature motif; other site 637380007194 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 637380007195 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 637380007196 Walker A/P-loop; other site 637380007197 ATP binding site [chemical binding]; other site 637380007198 Q-loop/lid; other site 637380007199 ABC transporter signature motif; other site 637380007200 Walker B; other site 637380007201 D-loop; other site 637380007202 H-loop/switch region; other site 637380007203 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 637380007204 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 637380007205 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 637380007206 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 637380007207 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 637380007208 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 637380007209 Cupin domain; Region: Cupin_2; cl09118 637380007210 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 637380007211 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 637380007212 putative active site; other site 637380007213 catalytic residue [active] 637380007214 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380007215 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 637380007216 active site 637380007217 NTP binding site [chemical binding]; other site 637380007218 metal binding triad [ion binding]; metal-binding site 637380007219 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 637380007220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380007221 H+ Antiporter protein; Region: 2A0121; TIGR00900 637380007222 putative substrate translocation pore; other site 637380007223 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637380007224 putative DNA binding site [nucleotide binding]; other site 637380007225 putative Zn2+ binding site [ion binding]; other site 637380007226 DinB superfamily; Region: DinB_2; cl00986 637380007227 nucleoside transporter; Region: nupC; TIGR00804 637380007228 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 637380007229 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 637380007230 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 637380007231 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 637380007232 putative catalytic cysteine [active] 637380007233 gamma-glutamyl kinase; Provisional; Region: PRK05429 637380007234 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 637380007235 nucleotide binding site [chemical binding]; other site 637380007236 homotetrameric interface [polypeptide binding]; other site 637380007237 putative phosphate binding site [ion binding]; other site 637380007238 putative allosteric binding site; other site 637380007239 PUA domain; Region: PUA; cl00607 637380007240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380007241 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 637380007242 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 637380007243 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 637380007244 putative metal binding site [ion binding]; other site 637380007245 putative dimer interface [polypeptide binding]; other site 637380007246 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380007247 Transcriptional regulator [Transcription]; Region: IclR; COG1414 637380007248 Bacterial transcriptional regulator; Region: IclR; pfam01614 637380007249 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380007250 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 637380007251 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 637380007252 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 637380007253 putative di-iron ligands [ion binding]; other site 637380007254 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cd00016 637380007255 dimer interface [polypeptide binding]; other site 637380007256 Alkaline phosphatase homologues; Region: alkPPc; smart00098 637380007257 active site 637380007258 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 637380007259 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 637380007260 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 637380007261 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 637380007262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 637380007263 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 637380007264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 637380007265 active site 637380007266 phosphorylation site [posttranslational modification] 637380007267 intermolecular recognition site; other site 637380007268 dimerization interface [polypeptide binding]; other site 637380007269 LytTr DNA-binding domain; Region: LytTR; cl04498 637380007270 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380007271 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380007272 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380007273 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 637380007274 active site 637380007275 metal binding site [ion binding]; metal-binding site 637380007276 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 637380007277 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380007278 MoxR-like ATPases [General function prediction only]; Region: COG0714 637380007279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380007280 Walker A motif; other site 637380007281 ATP binding site [chemical binding]; other site 637380007282 Walker B motif; other site 637380007283 arginine finger; other site 637380007284 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 637380007285 Protein of unknown function DUF58; Region: DUF58; pfam01882 637380007286 proline/glycine betaine transporter; Provisional; Region: PRK10642 637380007287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380007288 putative substrate translocation pore; other site 637380007289 potential frameshift: common BLAST hit: gi|227814177|ref|YP_002814186.1| glycosyl transferase, group 2 family protein 637380007290 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 637380007291 active site 637380007292 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 637380007293 active site 637380007294 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 637380007295 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 637380007296 Ligand binding site [chemical binding]; other site 637380007297 Putative Catalytic site [active] 637380007298 DXD motif; other site 637380007299 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 637380007300 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 637380007301 Ligand binding site [chemical binding]; other site 637380007302 Putative Catalytic site [active] 637380007303 DXD motif; other site 637380007304 acetylornithine aminotransferase; Provisional; Region: PRK02627 637380007305 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 637380007306 inhibitor-cofactor binding pocket; inhibition site 637380007307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380007308 catalytic residue [active] 637380007309 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 637380007310 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 637380007311 tetramer interface [polypeptide binding]; other site 637380007312 heme binding pocket [chemical binding]; other site 637380007313 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 637380007314 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 637380007315 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen...; Region: AdeC; cd01295 637380007316 active site 637380007317 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 637380007318 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 637380007319 putative trimer interface [polypeptide binding]; other site 637380007320 putative CoA binding site [chemical binding]; other site 637380007321 LysE type translocator; Region: LysE; cl00565 637380007322 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 637380007323 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 637380007324 putative deacylase active site [active] 637380007325 Beta-lactamase; Region: Beta-lactamase; cl01009 637380007326 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 637380007327 Protein of unknown function DUF58; Region: DUF58; pfam01882 637380007328 MoxR-like ATPases [General function prediction only]; Region: COG0714 637380007329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380007330 Walker A motif; other site 637380007331 ATP binding site [chemical binding]; other site 637380007332 Walker B motif; other site 637380007333 arginine finger; other site 637380007334 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 637380007335 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 637380007336 dimer interface [polypeptide binding]; other site 637380007337 FMN binding site [chemical binding]; other site 637380007338 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380007339 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 637380007340 Tet(M)-like subfamily. Tet(M), Tet(O), Tet(W), and OtrA are tetracycline resistance genes found in Gram-positive and Gram-negative bacteria. Tetracyclines inhibit protein synthesis by preventing aminoacyl-tRNA from binding to the ribosomal acceptor...; Region: TetM_like; cd04168 637380007341 putative GEF interaction site [polypeptide binding]; other site 637380007342 Switch I region; other site 637380007343 G2 box; other site 637380007344 G3 box; other site 637380007345 Switch II region; other site 637380007346 GTP/Mg2+ binding site [chemical binding]; other site 637380007347 G4 box; other site 637380007348 G5 box; other site 637380007349 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 637380007350 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines...; Region: Tet_like_IV; cd01684 637380007351 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a GTP-...; Region: Tet_C; cd03711 637380007352 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 637380007353 nudix motif; other site 637380007354 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637380007355 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 637380007356 Walker A/P-loop; other site 637380007357 ATP binding site [chemical binding]; other site 637380007358 Q-loop/lid; other site 637380007359 ABC transporter signature motif; other site 637380007360 Walker B; other site 637380007361 D-loop; other site 637380007362 H-loop/switch region; other site 637380007363 Predicted transcriptional regulators [Transcription]; Region: COG1725 637380007364 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637380007365 DNA-binding site [nucleotide binding]; DNA binding site 637380007366 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 637380007367 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 637380007368 putative NAD(P) binding site [chemical binding]; other site 637380007369 active site 637380007370 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637380007371 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637380007372 Walker A/P-loop; other site 637380007373 ATP binding site [chemical binding]; other site 637380007374 Q-loop/lid; other site 637380007375 ABC transporter signature motif; other site 637380007376 Walker B; other site 637380007377 D-loop; other site 637380007378 H-loop/switch region; other site 637380007379 FtsX-like permease family; Region: FtsX; pfam02687 637380007380 FtsX-like permease family; Region: FtsX; pfam02687 637380007381 Beta-lactamase; Region: Beta-lactamase; cl01009 637380007382 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 637380007383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637380007384 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 637380007385 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 637380007386 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380007387 Coenzyme A binding pocket [chemical binding]; other site 637380007388 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X...; Region: Nudix_Hydrolase_25; cd04684 637380007389 nudix motif; other site 637380007390 EamA-like transporter family; Region: EamA; cl01037 637380007391 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 637380007392 EamA-like transporter family; Region: EamA; cl01037 637380007393 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 637380007394 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637380007395 DNA-binding site [nucleotide binding]; DNA binding site 637380007396 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637380007397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380007398 homodimer interface [polypeptide binding]; other site 637380007399 catalytic residue [active] 637380007400 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 637380007401 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 637380007402 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 637380007403 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380007404 Active site [active] 637380007405 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637380007406 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 637380007407 active site 637380007408 metal binding site [ion binding]; metal-binding site 637380007409 Phosphotransferase enzyme family; Region: APH; pfam01636 637380007410 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637380007411 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 637380007412 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 637380007413 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380007414 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380007415 Amino acid permease; Region: AA_permease; pfam00324 637380007416 A new structural DNA glycosylase; Region: AlkD_like; cl11434 637380007417 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 637380007418 DNA binding residues [nucleotide binding] 637380007419 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 637380007420 dimer interface [polypeptide binding]; other site 637380007421 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 637380007422 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 637380007423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380007424 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 637380007425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380007426 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 637380007427 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637380007428 Catalytic site [active] 637380007429 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 637380007430 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637380007431 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637380007432 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 637380007433 NAD-dependent deacetylase; Provisional; Region: PRK14138 637380007434 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 637380007435 NAD+ binding site [chemical binding]; other site 637380007436 substrate binding site [chemical binding]; other site 637380007437 Zn binding site [ion binding]; other site 637380007438 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 637380007439 putative substrate binding pocket [chemical binding]; other site 637380007440 AC domain interface; other site 637380007441 catalytic triad [active] 637380007442 AB domain interface; other site 637380007443 interchain disulfide; other site 637380007444 N-terminal domain; Region: tspaseT_teng_N; TIGR01765 637380007445 Protein of unknown function (DUF979); Region: DUF979; cl01572 637380007446 Protein of unknown function (DUF969); Region: DUF969; cl01573 637380007447 LamB/YcsF family; Region: LamB_YcsF; cl00664 637380007448 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 637380007449 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 637380007450 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 637380007451 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 637380007452 Transcriptional regulator [Transcription]; Region: IclR; COG1414 637380007453 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380007454 Bacterial transcriptional regulator; Region: IclR; pfam01614 637380007455 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 637380007456 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637380007457 Catalytic site [active] 637380007458 CutC family; Region: CutC; cl01218 637380007459 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 637380007460 stage II sporulation protein P; Region: spore_II_P; TIGR02867 637380007461 Probable transposase; Region: OrfB_IS605; pfam01385 637380007462 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 637380007463 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637380007464 dimerization interface [polypeptide binding]; other site 637380007465 putative DNA binding site [nucleotide binding]; other site 637380007466 putative Zn2+ binding site [ion binding]; other site 637380007467 DinB superfamily; Region: DinB_2; cl00986 637380007468 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 637380007469 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 637380007470 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 637380007471 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 637380007472 putative active site [active] 637380007473 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380007474 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380007475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 637380007476 Nucleoside recognition; Region: Gate; cl00486 637380007477 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 637380007478 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such...; Region: APH_ChoK_like_1; cd05155 637380007479 putative active site [active] 637380007480 putative substrate binding site [chemical binding]; other site 637380007481 ATP binding site [chemical binding]; other site 637380007482 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380007483 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 637380007484 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 637380007485 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 637380007486 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380007487 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380007488 phosphoenolpyruvate synthase; Validated; Region: PRK06241 637380007489 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 637380007490 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 637380007491 potential frameshift: common BLAST hit: gi|118478415|ref|YP_895566.1| metallo-beta-lactamase family protein 637380007492 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380007493 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 637380007494 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 637380007495 Coat F domain; Region: Coat_F; cl02368 637380007496 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 637380007497 LysE type translocator; Region: LysE; cl00565 637380007498 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380007499 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 637380007500 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 637380007501 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 637380007502 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 637380007503 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 637380007504 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 637380007505 NAD binding site [chemical binding]; other site 637380007506 catalytic Zn binding site [ion binding]; other site 637380007507 structural Zn binding site [ion binding]; other site 637380007508 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 637380007509 dimanganese center [ion binding]; other site 637380007510 aspartate ammonia-lyase; Provisional; Region: PRK14515 637380007511 Aspartase; Region: Aspartase; cd01357 637380007512 active sites [active] 637380007513 tetramer interface [polypeptide binding]; other site 637380007514 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 637380007515 active site/substrate binding site [active] 637380007516 tetramer interface [polypeptide binding]; other site 637380007517 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637380007518 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380007519 non-specific DNA binding site [nucleotide binding]; other site 637380007520 salt bridge; other site 637380007521 sequence-specific DNA binding site [nucleotide binding]; other site 637380007522 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 637380007523 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 637380007524 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380007525 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 637380007526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380007527 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 637380007528 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 637380007529 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380007530 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 637380007531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380007532 Response regulator receiver domain; Region: Response_reg; pfam00072 637380007533 active site 637380007534 phosphorylation site [posttranslational modification] 637380007535 intermolecular recognition site; other site 637380007536 dimerization interface [polypeptide binding]; other site 637380007537 YcbB domain; Region: YcbB; pfam08664 637380007538 potential frameshift: common BLAST hit: gi|222096615|ref|YP_002530672.1| sensor histidine kinase 637380007539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380007540 ATP binding site [chemical binding]; other site 637380007541 Mg2+ binding site [ion binding]; other site 637380007542 G-X-G motif; other site 637380007543 Glutaminase; Region: Glutaminase; cl00907 637380007544 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 637380007545 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to...; Region: YbiR_permease; cd01117 637380007546 transmembrane helices; other site 637380007547 Cytochrome P450; Region: p450; cl12078 637380007548 Beta-lactamase; Region: Beta-lactamase; cl01009 637380007549 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 637380007550 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 637380007551 [2Fe-2S] cluster binding site [ion binding]; other site 637380007552 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 637380007553 MatE; Region: MatE; pfam01554 637380007554 MatE; Region: MatE; pfam01554 637380007555 potential frameshift: common BLAST hit: gi|217960564|ref|YP_002339128.1| amino acid permease 637380007556 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380007557 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380007558 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 637380007559 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 637380007560 putative active site [active] 637380007561 putative metal binding site [ion binding]; other site 637380007562 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 637380007563 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 637380007564 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 637380007565 tetramer interface [polypeptide binding]; other site 637380007566 heme binding pocket [chemical binding]; other site 637380007567 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637380007568 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380007569 Isochorismatase family; Region: Isochorismatase; pfam00857 637380007570 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012 637380007571 catalytic triad [active] 637380007572 dimer interface [polypeptide binding]; other site 637380007573 conserved cis-peptide bond; other site 637380007574 Isochorismatase family; Region: Isochorismatase; pfam00857 637380007575 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012 637380007576 catalytic triad [active] 637380007577 dimer interface [polypeptide binding]; other site 637380007578 conserved cis-peptide bond; other site 637380007579 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 637380007580 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 637380007581 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 637380007582 active site 637380007583 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637380007584 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380007585 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637380007586 dimerization interface [polypeptide binding]; other site 637380007587 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 637380007588 plasmid segregation protein ParM; Provisional; Region: PRK13917 637380007589 Heat induced stress protein YflT; Region: YflT; pfam11181 637380007590 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 637380007591 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 637380007592 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 637380007593 TspO/MBR family; Region: TspO_MBR; cl01379 637380007594 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 637380007595 DNA photolyase; Region: DNA_photolyase; pfam00875 637380007596 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 637380007597 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 637380007598 active site clefts [active] 637380007599 zinc binding site [ion binding]; other site 637380007600 dimer interface [polypeptide binding]; other site 637380007601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 637380007602 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 637380007603 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 637380007604 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 637380007605 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 637380007606 potential frameshift: common BLAST hit: gi|225865109|ref|YP_002750487.1| group-specific protein 637380007607 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 637380007608 Protein of unknown function DUF58; Region: DUF58; pfam01882 637380007609 MoxR-like ATPases [General function prediction only]; Region: COG0714 637380007610 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380007611 MoxR-like ATPases [General function prediction only]; Region: COG0714 637380007612 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 637380007613 UbiA prenyltransferase family; Region: UbiA; cl00337 637380007614 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637380007615 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637380007616 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637380007617 Walker A/P-loop; other site 637380007618 ATP binding site [chemical binding]; other site 637380007619 Q-loop/lid; other site 637380007620 ABC transporter signature motif; other site 637380007621 Walker B; other site 637380007622 D-loop; other site 637380007623 H-loop/switch region; other site 637380007624 FtsX-like permease family; Region: FtsX; pfam02687 637380007625 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 637380007626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380007627 ATP binding site [chemical binding]; other site 637380007628 Mg2+ binding site [ion binding]; other site 637380007629 G-X-G motif; other site 637380007630 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637380007631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380007632 active site 637380007633 dimerization interface [polypeptide binding]; other site 637380007634 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 637380007635 DNA binding residues [nucleotide binding] 637380007636 dimerization interface [polypeptide binding]; other site 637380007637 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 637380007638 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 637380007639 metal binding site [ion binding]; metal-binding site 637380007640 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 637380007641 ABC-ATPase subunit interface; other site 637380007642 dimer interface [polypeptide binding]; other site 637380007643 putative PBP binding regions; other site 637380007644 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 637380007645 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 637380007646 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 637380007647 conserved cys residue [active] 637380007648 Phosphotransferase enzyme family; Region: APH; pfam01636 637380007649 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637380007650 active site 637380007651 ATP binding site [chemical binding]; other site 637380007652 substrate binding site [chemical binding]; other site 637380007653 potential frameshift: common BLAST hit: gi|229604576|ref|YP_002867395.1| putative lipoprotein 637380007654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380007655 Low molecular weight phosphatase family; Region: LMWPc; cd00115 637380007656 Active site [active] 637380007657 Membrane transport protein; Region: Mem_trans; cl09117 637380007658 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 637380007659 putative metal binding site [ion binding]; other site 637380007660 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637380007661 dimerization interface [polypeptide binding]; other site 637380007662 putative DNA binding site [nucleotide binding]; other site 637380007663 putative Zn2+ binding site [ion binding]; other site 637380007664 Protein of unknown function (DUF1266); Region: DUF1266; cl14673 637380007665 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637380007666 binding surface 637380007667 TPR motif; other site 637380007668 Hsp70 protein; Region: HSP70; pfam00012 637380007669 short chain dehydrogenase; Provisional; Region: PRK12746 637380007670 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 637380007671 NADP binding site [chemical binding]; other site 637380007672 homodimer interface [polypeptide binding]; other site 637380007673 active site 637380007674 substrate binding site [chemical binding]; other site 637380007675 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380007676 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 637380007677 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 637380007678 metal binding site [ion binding]; metal-binding site 637380007679 DNA helicase, putative; Region: TIGR00376 637380007680 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 637380007681 putative active site [active] 637380007682 catalytic site [active] 637380007683 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 637380007684 active site 637380007685 metal binding site [ion binding]; metal-binding site 637380007686 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 637380007687 Beta-lactamase; Region: Beta-lactamase; cl01009 637380007688 hypothetical protein; Provisional; Region: PRK06770 637380007689 Putative mono-oxygenase ydhR; Region: ydhR; cl07420 637380007690 Transcriptional regulators [Transcription]; Region: MarR; COG1846 637380007691 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380007692 Cytochrome P450; Region: p450; cl12078 637380007693 ent-kaurene oxidase; Region: PLN02655 637380007694 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 637380007695 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 637380007696 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 637380007697 FAD binding pocket [chemical binding]; other site 637380007698 FAD binding motif [chemical binding]; other site 637380007699 catalytic residues [active] 637380007700 NAD binding pocket [chemical binding]; other site 637380007701 phosphate binding motif [ion binding]; other site 637380007702 beta-alpha-beta structure motif; other site 637380007703 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 637380007704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380007705 putative substrate translocation pore; other site 637380007706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380007707 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 637380007708 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 637380007709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380007710 active site 637380007711 phosphorylation site [posttranslational modification] 637380007712 intermolecular recognition site; other site 637380007713 dimerization interface [polypeptide binding]; other site 637380007714 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380007715 DNA binding site [nucleotide binding] 637380007716 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 637380007717 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 637380007718 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380007719 dimer interface [polypeptide binding]; other site 637380007720 phosphorylation site [posttranslational modification] 637380007721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380007722 ATP binding site [chemical binding]; other site 637380007723 G-X-G motif; other site 637380007724 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 637380007725 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 637380007726 D-cysteine desulfhydrase; Validated; Region: PRK03910 637380007727 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 637380007728 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637380007729 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 637380007730 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637380007731 active site 637380007732 metal binding site [ion binding]; metal-binding site 637380007733 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 637380007734 Beta-lactamase; Region: Beta-lactamase; cl01009 637380007735 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 637380007736 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380007737 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 637380007738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380007739 NAD(P) binding site [chemical binding]; other site 637380007740 active site 637380007741 hypothetical protein; Provisional; Region: PRK06849 637380007742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380007743 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 637380007744 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 637380007745 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 637380007746 dimer interface [polypeptide binding]; other site 637380007747 active site 637380007748 CoA binding pocket [chemical binding]; other site 637380007749 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 637380007750 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 637380007751 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 637380007752 DNA binding residues [nucleotide binding] 637380007753 Leucine carboxyl methyltransferase; Region: LCM; cl01306 637380007754 polynucleotide kinase; Provisional; Region: pseT; PHA02530 637380007755 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 637380007756 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 637380007757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 637380007758 Rhodopirellula transposase; Region: DDE_Tnp_ISAZ013; pfam07592 637380007759 Integrase core domain; Region: rve; cl01316 637380007760 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637380007761 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 637380007762 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637380007763 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637380007764 Walker A/P-loop; other site 637380007765 ATP binding site [chemical binding]; other site 637380007766 Q-loop/lid; other site 637380007767 ABC transporter signature motif; other site 637380007768 Walker B; other site 637380007769 D-loop; other site 637380007770 H-loop/switch region; other site 637380007771 FtsX-like permease family; Region: FtsX; pfam02687 637380007772 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637380007773 dimerization interface [polypeptide binding]; other site 637380007774 putative DNA binding site [nucleotide binding]; other site 637380007775 Predicted transcriptional regulator [Transcription]; Region: COG2345 637380007776 putative Zn2+ binding site [ion binding]; other site 637380007777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380007778 H+ Antiporter protein; Region: 2A0121; TIGR00900 637380007779 putative substrate translocation pore; other site 637380007780 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 637380007781 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637380007782 dimerization interface [polypeptide binding]; other site 637380007783 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380007784 dimer interface [polypeptide binding]; other site 637380007785 phosphorylation site [posttranslational modification] 637380007786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380007787 ATP binding site [chemical binding]; other site 637380007788 Mg2+ binding site [ion binding]; other site 637380007789 G-X-G motif; other site 637380007790 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380007791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380007792 active site 637380007793 phosphorylation site [posttranslational modification] 637380007794 intermolecular recognition site; other site 637380007795 dimerization interface [polypeptide binding]; other site 637380007796 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380007797 DNA binding site [nucleotide binding] 637380007798 Predicted membrane protein [Function unknown]; Region: COG2364 637380007799 Transcriptional regulators [Transcription]; Region: MarR; COG1846 637380007800 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380007801 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 637380007802 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380007803 Coenzyme A binding pocket [chemical binding]; other site 637380007804 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 637380007805 Uncharacterized conserved protein [Function unknown]; Region: COG1284 637380007806 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637380007807 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 637380007808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380007809 D-galactonate transporter; Region: 2A0114; TIGR00893 637380007810 putative substrate translocation pore; other site 637380007811 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 637380007812 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 637380007813 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 637380007814 4Fe-4S binding domain; Region: Fer4; cl02805 637380007815 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 637380007816 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 637380007817 Cysteine-rich domain; Region: CCG; pfam02754 637380007818 Cysteine-rich domain; Region: CCG; pfam02754 637380007819 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637380007820 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380007821 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637380007822 dimerization interface [polypeptide binding]; other site 637380007823 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 637380007824 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 637380007825 putative dimer interface [polypeptide binding]; other site 637380007826 catalytic triad [active] 637380007827 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 637380007828 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 637380007829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380007830 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 637380007831 L-serine binding site [chemical binding]; other site 637380007832 ACT domain interface; other site 637380007833 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active...; Region: PSAT_like; cd00611 637380007834 homodimer interface [polypeptide binding]; other site 637380007835 substrate-cofactor binding pocket; other site 637380007836 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380007837 catalytic residue [active] 637380007838 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 637380007839 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637380007840 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 637380007841 Domain of unknown function (DUF378); Region: DUF378; cl00943 637380007842 Cupin domain; Region: Cupin_2; cl09118 637380007843 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637380007844 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637380007845 potential frameshift: common BLAST hit: gi|229603249|ref|YP_002867502.1| beta-lactam antibiotic acylase family protein 637380007846 Penicillin amidase; Region: Penicil_amidase; pfam01804 637380007847 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-...; Region: Ntn_PGA_like; cd03747 637380007848 active site 637380007849 potential frameshift: common BLAST hit: gi|218904424|ref|YP_002452258.1| beta-lactam antibiotic acylase family protein 637380007850 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 637380007851 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 637380007852 active site 637380007853 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 637380007854 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 637380007855 amidase catalytic site [active] 637380007856 Zn binding residues [ion binding]; other site 637380007857 substrate binding site [chemical binding]; other site 637380007858 Bacterial SH3 domain; Region: SH3_3; cl02551 637380007859 S-layer homology domain; Region: SLH; pfam00395 637380007860 S-layer homology domain; Region: SLH; pfam00395 637380007861 S-layer homology domain; Region: SLH; pfam00395 637380007862 A new structural DNA glycosylase; Region: AlkD_like; cd06561 637380007863 Active site [active] 637380007864 S-layer homology domain; Region: SLH; pfam00395 637380007865 S-layer homology domain; Region: SLH; pfam00395 637380007866 S-layer homology domain; Region: SLH; pfam00395 637380007867 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 637380007868 putative metal binding site [ion binding]; other site 637380007869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380007870 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637380007871 putative substrate translocation pore; other site 637380007872 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380007873 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637380007874 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380007875 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380007876 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637380007877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380007878 putative substrate translocation pore; other site 637380007879 Beta-lactamase; Region: Beta-lactamase; cl01009 637380007880 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 637380007881 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380007882 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380007883 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 637380007884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380007885 putative substrate translocation pore; other site 637380007886 Transcriptional regulators [Transcription]; Region: MarR; COG1846 637380007887 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380007888 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 637380007889 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380007890 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 637380007891 Uncharacterized conserved protein [Function unknown]; Region: COG4715 637380007892 SWIM zinc finger; Region: SWIM; cl11618 637380007893 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 637380007894 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 637380007895 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 637380007896 Walker A/P-loop; other site 637380007897 ATP binding site [chemical binding]; other site 637380007898 Q-loop/lid; other site 637380007899 ABC transporter signature motif; other site 637380007900 Walker B; other site 637380007901 D-loop; other site 637380007902 H-loop/switch region; other site 637380007903 Domain II of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. The...; Region: ABC_cobalt_CbiO_domain2; cd03226 637380007904 Walker A/P-loop; other site 637380007905 ATP binding site [chemical binding]; other site 637380007906 Q-loop/lid; other site 637380007907 ABC transporter signature motif; other site 637380007908 Walker B; other site 637380007909 D-loop; other site 637380007910 H-loop/switch region; other site 637380007911 Cobalt transport protein; Region: CbiQ; cl00463 637380007912 Calreticulin family; Region: Calreticulin; pfam00262 637380007913 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 637380007914 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 637380007915 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380007916 Predicted membrane protein [Function unknown]; Region: COG1288 637380007917 Endonuclease I; Region: Endonuclease_1; cl01003 637380007918 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637380007919 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380007920 non-specific DNA binding site [nucleotide binding]; other site 637380007921 salt bridge; other site 637380007922 sequence-specific DNA binding site [nucleotide binding]; other site 637380007923 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002 637380007924 putative deacylase active site [active] 637380007925 histidyl-tRNA synthetase; Provisional; Region: PRK12420 637380007926 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 637380007927 dimer interface [polypeptide binding]; other site 637380007928 motif 1; other site 637380007929 active site 637380007930 motif 2; other site 637380007931 motif 3; other site 637380007932 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 637380007933 anticodon binding site; other site 637380007934 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380007935 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 637380007936 dimer interface [polypeptide binding]; other site 637380007937 FMN binding site [chemical binding]; other site 637380007938 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 637380007939 active site 637380007940 domain interfaces; other site 637380007941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380007942 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 637380007943 NAD(P) binding site [chemical binding]; other site 637380007944 active site 637380007945 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 637380007946 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 637380007947 Walker A/P-loop; other site 637380007948 ATP binding site [chemical binding]; other site 637380007949 Q-loop/lid; other site 637380007950 ABC transporter signature motif; other site 637380007951 Walker B; other site 637380007952 D-loop; other site 637380007953 H-loop/switch region; other site 637380007954 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 637380007955 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380007956 non-specific DNA binding site [nucleotide binding]; other site 637380007957 salt bridge; other site 637380007958 sequence-specific DNA binding site [nucleotide binding]; other site 637380007959 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 637380007960 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637380007961 motif II; other site 637380007962 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 637380007963 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 637380007964 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 637380007965 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 637380007966 nudix motif; other site 637380007967 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 637380007968 putative metal binding site [ion binding]; other site 637380007969 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 637380007970 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 637380007971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380007972 putative substrate translocation pore; other site 637380007973 maltose O-acetyltransferase; Provisional; Region: PRK10092 637380007974 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 637380007975 active site 637380007976 substrate binding site [chemical binding]; other site 637380007977 trimer interface [polypeptide binding]; other site 637380007978 CoA binding site [chemical binding]; other site 637380007979 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 637380007980 FtsX-like permease family; Region: FtsX; pfam02687 637380007981 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 637380007982 FtsX-like permease family; Region: FtsX; pfam02687 637380007983 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637380007984 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637380007985 Walker A/P-loop; other site 637380007986 ATP binding site [chemical binding]; other site 637380007987 Q-loop/lid; other site 637380007988 ABC transporter signature motif; other site 637380007989 Walker B; other site 637380007990 D-loop; other site 637380007991 H-loop/switch region; other site 637380007992 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 637380007993 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 637380007994 active site 637380007995 HIGH motif; other site 637380007996 dimer interface [polypeptide binding]; other site 637380007997 KMSKS motif; other site 637380007998 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 637380007999 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 637380008000 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 637380008001 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 637380008002 Domain of unknown function DUF20; Region: UPF0118; cl00465 637380008003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380008004 BACI_c33090; ydaO/yuaA leader, RF00379 637380008005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380008006 S-adenosylmethionine binding site [chemical binding]; other site 637380008007 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 637380008008 CGNR zinc finger; Region: zf-CGNR; pfam11706 637380008009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380008010 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637380008011 putative substrate translocation pore; other site 637380008012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637380008013 binding surface 637380008014 TPR motif; other site 637380008015 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 637380008016 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 637380008017 hypothetical protein; Provisional; Region: PRK04164 637380008018 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 637380008019 Domain of unknown function DUF21; Region: DUF21; pfam01595 637380008020 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 637380008021 Transporter associated domain; Region: CorC_HlyC; pfam03471 637380008022 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 637380008023 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 637380008024 DNA binding residues [nucleotide binding] 637380008025 putative dimer interface [polypeptide binding]; other site 637380008026 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 637380008027 substrate binding site [chemical binding]; other site 637380008028 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 637380008029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380008030 NAD(P) binding site [chemical binding]; other site 637380008031 active site 637380008032 Hypothetical methyltransferase; Region: Methyltransf_13; pfam08421 637380008033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380008034 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 637380008035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380008036 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 637380008037 NAD(P) binding site [chemical binding]; other site 637380008038 active site 637380008039 Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization...; Region: SH3; cl09950 637380008040 EamA-like transporter family; Region: EamA; cl01037 637380008041 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 637380008042 EamA-like transporter family; Region: EamA; cl01037 637380008043 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 637380008044 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 637380008045 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 637380008046 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 637380008047 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 637380008048 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 637380008049 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380008050 gluconate transporter; Region: gntP; TIGR00791 637380008051 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 637380008052 active site 637380008053 intersubunit interactions; other site 637380008054 catalytic residue [active] 637380008055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380008056 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 637380008057 transketolase; Reviewed; Region: PRK05899 637380008058 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 637380008059 TPP-binding site [chemical binding]; other site 637380008060 dimer interface [polypeptide binding]; other site 637380008061 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637380008062 PYR/PP interface [polypeptide binding]; other site 637380008063 dimer interface [polypeptide binding]; other site 637380008064 TPP binding site [chemical binding]; other site 637380008065 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637380008066 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 637380008067 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 637380008068 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 637380008069 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 637380008070 potential frameshift: common BLAST hit: gi|227813788|ref|YP_002813797.1| alcohol dehydrogenase, zinc-containing 637380008071 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 637380008072 putative NAD(P) binding site [chemical binding]; other site 637380008073 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 637380008074 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 637380008075 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 637380008076 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 637380008077 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 637380008078 putative NAD(P) binding site [chemical binding]; other site 637380008079 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 637380008080 classical (c) SDRs; Region: SDR_c; cd05233 637380008081 NAD(P) binding site [chemical binding]; other site 637380008082 active site 637380008083 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 637380008084 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 637380008085 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 637380008086 active site 637380008087 Zn binding site [ion binding]; other site 637380008088 Viral enhancin protein; Region: Enhancin; pfam03272 637380008089 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 637380008090 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637380008091 dimerization interface [polypeptide binding]; other site 637380008092 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 637380008093 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl01869 637380008094 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 637380008095 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 637380008096 catalytic motif [active] 637380008097 Zn binding site [ion binding]; other site 637380008098 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 637380008099 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 637380008100 dimerization interface [polypeptide binding]; other site 637380008101 active site 637380008102 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380008103 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 637380008104 dimer interface [polypeptide binding]; other site 637380008105 FMN binding site [chemical binding]; other site 637380008106 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 637380008107 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637380008108 active site 637380008109 catalytic tetrad [active] 637380008110 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 637380008111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380008112 putative substrate translocation pore; other site 637380008113 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 637380008114 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 637380008115 Domain of unknown function (DUF336); Region: DUF336; cl01249 637380008116 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 637380008117 active site 637380008118 metal binding site [ion binding]; metal-binding site 637380008119 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 637380008120 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380008121 IDEAL domain; Region: IDEAL; pfam08858 637380008122 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380008123 Rrf2 family protein; Region: rrf2_super; TIGR00738 637380008124 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting...; Region: ArsC_Spx; cd03032 637380008125 putative catalytic residues [active] 637380008126 thiol/disulfide switch; other site 637380008127 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380008128 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 637380008129 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637380008130 DNA-binding site [nucleotide binding]; DNA binding site 637380008131 UTRA domain; Region: UTRA; cl06649 637380008132 putative oxidoreductase; Provisional; Region: PRK10206 637380008133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380008134 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 637380008135 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 637380008136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380008137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380008138 S-adenosylmethionine binding site [chemical binding]; other site 637380008139 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380008140 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380008141 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637380008142 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 637380008143 active site 637380008144 catalytic tetrad [active] 637380008145 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 637380008146 putative hydrophobic ligand binding site [chemical binding]; other site 637380008147 protein interface [polypeptide binding]; other site 637380008148 gate; other site 637380008149 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380008150 Phosphotransferase enzyme family; Region: APH; pfam01636 637380008151 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl10490 637380008152 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 637380008153 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 637380008154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380008155 Coenzyme A binding pocket [chemical binding]; other site 637380008156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380008157 short chain dehydrogenase; Provisional; Region: PRK12828 637380008158 NAD(P) binding site [chemical binding]; other site 637380008159 active site 637380008160 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380008161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380008162 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 637380008163 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 637380008164 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 637380008165 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380008166 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637380008167 dimerization interface [polypeptide binding]; other site 637380008168 putative DNA binding site [nucleotide binding]; other site 637380008169 putative Zn2+ binding site [ion binding]; other site 637380008170 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 637380008171 active site 637380008172 Glycosyl hydrolase family 18; Region: Glyco_18; smart00636 637380008173 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 637380008174 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 637380008175 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 637380008176 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 637380008177 DXD motif; other site 637380008178 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 637380008179 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 637380008180 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637380008181 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 637380008182 active site 637380008183 Domain of unknown function (DUF74); Region: DUF74; cl00426 637380008184 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 637380008185 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380008186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380008187 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 637380008188 Predicted transcriptional regulator [Transcription]; Region: COG2378 637380008189 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380008190 Protein of unknown function (DUF805); Region: DUF805; cl01224 637380008191 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637380008192 PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 637380008193 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380008194 Walker A/P-loop; other site 637380008195 ATP binding site [chemical binding]; other site 637380008196 Q-loop/lid; other site 637380008197 ABC transporter signature motif; other site 637380008198 Walker B; other site 637380008199 D-loop; other site 637380008200 H-loop/switch region; other site 637380008201 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 637380008202 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380008203 hydroxylamine reductase; Provisional; Region: PRK12310 637380008204 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 637380008205 ACS interaction site; other site 637380008206 CODH interaction site; other site 637380008207 metal cluster binding site [ion binding]; other site 637380008208 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380008209 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the...; Region: GH25_muramidase_1; cd06413 637380008210 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 637380008211 active site 637380008212 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 637380008213 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 637380008214 hypothetical protein; Provisional; Region: PRK06771 637380008215 Beta-lactamase; Region: Beta-lactamase; cl01009 637380008216 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 637380008217 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380008218 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637380008219 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 637380008220 active site 637380008221 metal binding site [ion binding]; metal-binding site 637380008222 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 637380008223 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 637380008224 ligand binding site [chemical binding]; other site 637380008225 flexible hinge region; other site 637380008226 Protein of unknown function, DUF606; Region: DUF606; cl01273 637380008227 Protein of unknown function, DUF606; Region: DUF606; cl01273 637380008228 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380008229 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 637380008230 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 637380008231 putative NAD(P) binding site [chemical binding]; other site 637380008232 dimer interface [polypeptide binding]; other site 637380008233 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380008234 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 637380008235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380008236 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 637380008237 putative substrate translocation pore; other site 637380008238 Haemolysin XhlA; Region: XhlA; pfam10779 637380008239 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 637380008240 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 637380008241 Citrate transporter; Region: CitMHS; pfam03600 637380008242 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 637380008243 transmembrane helices; other site 637380008244 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380008245 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380008246 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 637380008247 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: FeuA; cd01138 637380008248 putative ligand binding residues [chemical binding]; other site 637380008249 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 637380008250 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 637380008251 ABC-ATPase subunit interface; other site 637380008252 dimer interface [polypeptide binding]; other site 637380008253 putative PBP binding regions; other site 637380008254 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 637380008255 ABC-ATPase subunit interface; other site 637380008256 dimer interface [polypeptide binding]; other site 637380008257 putative PBP binding regions; other site 637380008258 Protein of unknown function (DUF817); Region: DUF817; cl01520 637380008259 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 637380008260 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 637380008261 DinB superfamily; Region: DinB_2; cl00986 637380008262 DinB superfamily; Region: DinB_2; cl00986 637380008263 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 637380008264 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 637380008265 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637380008266 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380008267 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637380008268 dimerization interface [polypeptide binding]; other site 637380008269 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 637380008270 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 637380008271 NADP binding site [chemical binding]; other site 637380008272 dimer interface [polypeptide binding]; other site 637380008273 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637380008274 catalytic core [active] 637380008275 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380008276 Coenzyme A binding pocket [chemical binding]; other site 637380008277 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 637380008278 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380008279 Walker A/P-loop; other site 637380008280 ATP binding site [chemical binding]; other site 637380008281 Q-loop/lid; other site 637380008282 ABC transporter signature motif; other site 637380008283 Walker B; other site 637380008284 D-loop; other site 637380008285 H-loop/switch region; other site 637380008286 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 637380008287 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 637380008288 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 637380008289 N-acetyltransferase; Region: Acetyltransf_2; cl00949 637380008290 oligoendopeptidase F; Region: pepF; TIGR00181 637380008291 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 637380008292 active site 637380008293 Zn binding site [ion binding]; other site 637380008294 Beta-lactamase; Region: Beta-lactamase; cl01009 637380008295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380008296 putative substrate translocation pore; other site 637380008297 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637380008298 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637380008299 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380008300 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 637380008301 putative dimerization interface [polypeptide binding]; other site 637380008302 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 637380008303 putative active site [active] 637380008304 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 637380008305 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 637380008306 active site 637380008307 catalytic site [active] 637380008308 metal binding site [ion binding]; metal-binding site 637380008309 FAD binding domain; Region: FAD_binding_3; pfam01494 637380008310 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380008311 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 637380008312 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637380008313 dimerization interface [polypeptide binding]; other site 637380008314 putative DNA binding site [nucleotide binding]; other site 637380008315 putative Zn2+ binding site [ion binding]; other site 637380008316 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 637380008317 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 637380008318 putative NAD(P) binding site [chemical binding]; other site 637380008319 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 637380008320 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 637380008321 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 637380008322 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 637380008323 Uncharacterised protein family (UPF0157); Region: UPF0157; cl00987 637380008324 Membrane transport protein; Region: Mem_trans; cl09117 637380008325 Membrane transport protein; Region: Mem_trans; cl09117 637380008326 D-lactate dehydrogenase [cytochrome]; Region: PLN02805 637380008327 FAD binding domain; Region: FAD_binding_4; pfam01565 637380008328 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 637380008329 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 637380008330 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 637380008331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380008332 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-...; Region: LbH_MAT_like; cd04647 637380008333 trimer interface [polypeptide binding]; other site 637380008334 active site 637380008335 substrate binding site [chemical binding]; other site 637380008336 CoA binding site [chemical binding]; other site 637380008337 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 637380008338 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 637380008339 inhibitor-cofactor binding pocket; inhibition site 637380008340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380008341 catalytic residue [active] 637380008342 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 637380008343 active site 637380008344 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 637380008345 active site 637380008346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380008347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380008348 enoyl-CoA hydratase; Provisional; Region: PRK06688 637380008349 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 637380008350 substrate binding site [chemical binding]; other site 637380008351 oxyanion hole (OAH) forming residues; other site 637380008352 trimer interface [polypeptide binding]; other site 637380008353 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 637380008354 Collagenase; Region: Peptidase_M9; pfam01752 637380008355 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 637380008356 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 637380008357 MgtC family; Region: MgtC; cl12207 637380008358 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380008359 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 637380008360 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 637380008361 putative metal binding site [ion binding]; other site 637380008362 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 637380008363 active site 637380008364 metal binding site [ion binding]; metal-binding site 637380008365 VanW like protein; Region: VanW; pfam04294 637380008366 exonuclease; Provisional; Region: PRK06722 637380008367 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 637380008368 active site 637380008369 substrate binding site [chemical binding]; other site 637380008370 catalytic site [active] 637380008371 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 637380008372 DNA-binding site [nucleotide binding]; DNA binding site 637380008373 RNA-binding motif; other site 637380008374 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 637380008375 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 637380008376 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 637380008377 nudix motif; other site 637380008378 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 637380008379 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 637380008380 trimer interface [polypeptide binding]; other site 637380008381 active site 637380008382 substrate binding site [chemical binding]; other site 637380008383 CoA binding site [chemical binding]; other site 637380008384 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008385 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008386 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008387 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008388 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008389 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008390 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008391 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008392 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008393 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008394 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008395 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008396 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008397 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008398 short chain dehydrogenase; Provisional; Region: PRK06924 637380008399 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 637380008400 NADP binding site [chemical binding]; other site 637380008401 homodimer interface [polypeptide binding]; other site 637380008402 active site 637380008403 Predicted acetyltransferase [General function prediction only]; Region: COG3393 637380008404 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380008405 argininosuccinate lyase; Provisional; Region: PRK06705 637380008406 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 637380008407 active sites [active] 637380008408 tetramer interface [polypeptide binding]; other site 637380008409 Beta-lactamase; Region: Beta-lactamase; cl01009 637380008410 Beta-lactamase; Region: Beta-lactamase; cl01009 637380008411 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 637380008412 active site 637380008413 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 637380008414 Sodium:solute symporter family; Region: SSF; cl00456 637380008415 Protein of unknown function (DUF997); Region: DUF997; cl01614 637380008416 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 637380008417 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 637380008418 NAD(P) binding site [chemical binding]; other site 637380008419 catalytic residues [active] 637380008420 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 637380008421 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 637380008422 NAD(P) binding site [chemical binding]; other site 637380008423 homotetramer interface [polypeptide binding]; other site 637380008424 homodimer interface [polypeptide binding]; other site 637380008425 active site 637380008426 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 637380008427 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 637380008428 Divergent PAP2 family; Region: DUF212; cl00855 637380008429 Predicted permeases [General function prediction only]; Region: RarD; COG2962 637380008430 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 637380008431 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 637380008432 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 637380008433 Walker A motif; other site 637380008434 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 637380008435 MoaE interaction surface [polypeptide binding]; other site 637380008436 thiocarboxylated glycine; other site 637380008437 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 637380008438 MoaE homodimer interface [polypeptide binding]; other site 637380008439 MoaD interaction [polypeptide binding]; other site 637380008440 active site residues [active] 637380008441 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 637380008442 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 637380008443 dimer interface [polypeptide binding]; other site 637380008444 putative functional site; other site 637380008445 putative MPT binding site; other site 637380008446 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 637380008447 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 637380008448 ATP binding site [chemical binding]; other site 637380008449 substrate interface [chemical binding]; other site 637380008450 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 637380008451 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 637380008452 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 637380008453 FeS/SAM binding site; other site 637380008454 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 637380008455 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 637380008456 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 637380008457 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 637380008458 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 637380008459 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 637380008460 catalytic loop [active] 637380008461 iron binding site [ion binding]; other site 637380008462 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 637380008463 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 637380008464 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H)...; Region: MopB_Formate-Dh-H; cd02753 637380008465 [4Fe-4S] binding site [ion binding]; other site 637380008466 molybdopterin cofactor binding site; other site 637380008467 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 637380008468 molybdopterin cofactor binding site; other site 637380008469 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 637380008470 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380008471 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 637380008472 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 637380008473 metal ion-dependent adhesion site (MIDAS); other site 637380008474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380008475 S-adenosylmethionine binding site [chemical binding]; other site 637380008476 O-methyltransferase; Region: Methyltransf_2; pfam00891 637380008477 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 637380008478 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637380008479 peptide binding site [polypeptide binding]; other site 637380008480 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 637380008481 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637380008482 peptide binding site [polypeptide binding]; other site 637380008483 potential frameshift: common BLAST hit: gi|222098303|ref|YP_002532360.1| Transposase 637380008484 putative transposase OrfB; Reviewed; Region: PHA02517 637380008485 Rhodopirellula transposase; Region: DDE_Tnp_ISAZ013; pfam07592 637380008486 Integrase core domain; Region: rve; cl01316 637380008487 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 637380008488 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637380008489 peptide binding site [polypeptide binding]; other site 637380008490 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 637380008491 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 637380008492 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 637380008493 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637380008494 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 637380008495 DNA binding residues [nucleotide binding] 637380008496 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 637380008497 active site 637380008498 metal binding site [ion binding]; metal-binding site 637380008499 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637380008500 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637380008501 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 637380008502 Walker A/P-loop; other site 637380008503 ATP binding site [chemical binding]; other site 637380008504 Q-loop/lid; other site 637380008505 ABC transporter signature motif; other site 637380008506 Walker B; other site 637380008507 D-loop; other site 637380008508 H-loop/switch region; other site 637380008509 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380008510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380008511 putative oxidoreductase; Provisional; Region: PRK11579 637380008512 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380008513 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 637380008514 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 637380008515 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 637380008516 CAP-like domain; other site 637380008517 Active site [active] 637380008518 primary dimer interface [polypeptide binding]; other site 637380008519 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637380008520 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637380008521 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 637380008522 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380008523 ATP binding site [chemical binding]; other site 637380008524 Mg2+ binding site [ion binding]; other site 637380008525 G-X-G motif; other site 637380008526 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 637380008527 anchoring element; other site 637380008528 dimer interface [polypeptide binding]; other site 637380008529 ATP binding site [chemical binding]; other site 637380008530 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 637380008531 active site 637380008532 putative metal-binding site [ion binding]; other site 637380008533 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 637380008534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380008535 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 637380008536 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 637380008537 protein binding site [polypeptide binding]; other site 637380008538 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380008539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380008540 active site 637380008541 phosphorylation site [posttranslational modification] 637380008542 intermolecular recognition site; other site 637380008543 dimerization interface [polypeptide binding]; other site 637380008544 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380008545 DNA binding site [nucleotide binding] 637380008546 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 637380008547 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 637380008548 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 637380008549 Class III ribonucleotide reductase; Region: RNR_III; cd01675 637380008550 effector binding site; other site 637380008551 active site 637380008552 Zn binding site [ion binding]; other site 637380008553 glycine loop; other site 637380008554 Domain of unknown function (DUF205); Region: DUF205; cl00410 637380008555 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 637380008556 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 637380008557 active site 637380008558 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 637380008559 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 637380008560 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 637380008561 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 637380008562 putative peptidoglycan binding site; other site 637380008563 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 637380008564 active site 637380008565 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830; cl07951 637380008566 Small acid-soluble spore protein N family; Region: SspN; cl11659 637380008567 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 637380008568 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 637380008569 active site 637380008570 substrate binding site [chemical binding]; other site 637380008571 catalytic site [active] 637380008572 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 637380008573 catalytic residues [active] 637380008574 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637380008575 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637380008576 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380008577 Walker A/P-loop; other site 637380008578 ATP binding site [chemical binding]; other site 637380008579 Q-loop/lid; other site 637380008580 ABC transporter signature motif; other site 637380008581 Walker B; other site 637380008582 D-loop; other site 637380008583 H-loop/switch region; other site 637380008584 aconitate hydratase; Validated; Region: PRK09277 637380008585 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 637380008586 substrate binding site [chemical binding]; other site 637380008587 ligand binding site [chemical binding]; other site 637380008588 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 637380008589 substrate binding site [chemical binding]; other site 637380008590 Small acid-soluble spore protein O family; Region: SspO; cl07943 637380008591 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 637380008592 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 637380008593 putative dimer interface [polypeptide binding]; other site 637380008594 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637380008595 alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902 637380008596 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 637380008597 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 637380008598 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 637380008599 nudix motif; other site 637380008600 SAP domain; Region: SAP; cl02640 637380008601 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 637380008602 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 637380008603 dimer interface [polypeptide binding]; other site 637380008604 active site 637380008605 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 637380008606 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637380008607 Transposase [DNA replication, recombination, and repair]; Region: COG5421 637380008608 acyl-CoA synthetase; Validated; Region: PRK06164 637380008609 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 637380008610 BioY family; Region: BioY; cl00560 637380008611 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 637380008612 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 637380008613 S-layer homology domain; Region: SLH; pfam00395 637380008614 S-layer homology domain; Region: SLH; pfam00395 637380008615 S-layer homology domain; Region: SLH; pfam00395 637380008616 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 637380008617 active site 637380008618 catalytic motif [active] 637380008619 Zn binding site [ion binding]; other site 637380008620 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 637380008621 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 637380008622 amidase catalytic site [active] 637380008623 Zn binding residues [ion binding]; other site 637380008624 substrate binding site [chemical binding]; other site 637380008625 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 637380008626 Active site [active] 637380008627 Uncharacterized conserved protein [Function unknown]; Region: COG1284 637380008628 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 637380008629 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 637380008630 dimer interface [polypeptide binding]; other site 637380008631 putative metal binding site [ion binding]; other site 637380008632 PAS domain S-box; Region: sensory_box; TIGR00229 637380008633 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 637380008634 sensory histidine kinase AtoS; Provisional; Region: PRK11360 637380008635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 637380008636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380008637 ATP binding site [chemical binding]; other site 637380008638 Mg2+ binding site [ion binding]; other site 637380008639 G-X-G motif; other site 637380008640 Predicted esterase [General function prediction only]; Region: COG0400 637380008641 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380008642 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 637380008643 Zn binding site [ion binding]; other site 637380008644 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 637380008645 Zn binding site [ion binding]; other site 637380008646 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 637380008647 Sodium:solute symporter family; Region: SSF; cl00456 637380008648 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 637380008649 active site 637380008650 FMN binding site [chemical binding]; other site 637380008651 substrate binding site [chemical binding]; other site 637380008652 3Fe-4S cluster binding site [ion binding]; other site 637380008653 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 637380008654 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 637380008655 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 637380008656 FMN binding site [chemical binding]; other site 637380008657 active site 637380008658 substrate binding site [chemical binding]; other site 637380008659 catalytic residue [active] 637380008660 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 637380008661 Arginase family; Region: Arginase; cl00306 637380008662 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 637380008663 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria...; Region: Imidazolone-5PH; cd01296 637380008664 active site 637380008665 urocanate hydratase; Region: hutU; TIGR01228 637380008666 urocanate hydratase; Provisional; Region: PRK05414 637380008667 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 637380008668 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 637380008669 active sites [active] 637380008670 tetramer interface [polypeptide binding]; other site 637380008671 HutP; Region: HutP; cl07944 637380008672 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380008673 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 637380008674 conserved cys residue [active] 637380008675 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380008676 Active site [active] 637380008677 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 637380008678 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008679 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008680 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008681 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008682 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008683 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008684 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008685 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008686 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008687 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008688 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008689 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008690 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008691 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008692 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008693 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008694 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008695 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008696 Domain of unknown function DUF11; Region: DUF11; cl03172 637380008697 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 637380008698 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 637380008699 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 637380008700 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 637380008701 EamA-like transporter family; Region: EamA; cl01037 637380008702 YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 637380008703 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 637380008704 metal binding site [ion binding]; metal-binding site 637380008705 dimer interface [polypeptide binding]; other site 637380008706 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637380008707 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637380008708 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380008709 Walker A/P-loop; other site 637380008710 ATP binding site [chemical binding]; other site 637380008711 Q-loop/lid; other site 637380008712 ABC transporter signature motif; other site 637380008713 Walker B; other site 637380008714 D-loop; other site 637380008715 H-loop/switch region; other site 637380008716 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 637380008717 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380008718 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 637380008719 putative dimerization interface [polypeptide binding]; other site 637380008720 putative substrate binding pocket [chemical binding]; other site 637380008721 LrgA family; Region: LrgA; cl00608 637380008722 LrgB-like family; Region: LrgB; cl00596 637380008723 potential frameshift: common BLAST hit: gi|118478907|ref|YP_896058.1| MutT/NUDIX family protein 637380008724 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 637380008725 nudix motif; other site 637380008726 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 637380008727 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 637380008728 amidase catalytic site [active] 637380008729 Zn binding residues [ion binding]; other site 637380008730 substrate binding site [chemical binding]; other site 637380008731 S-layer homology domain; Region: SLH; pfam00395 637380008732 S-layer homology domain; Region: SLH; pfam00395 637380008733 S-layer homology domain; Region: SLH; pfam00395 637380008734 Nuclease-related domain; Region: NERD; pfam08378 637380008735 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 637380008736 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637380008737 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 637380008738 Walker A/P-loop; other site 637380008739 ATP binding site [chemical binding]; other site 637380008740 Q-loop/lid; other site 637380008741 ABC transporter signature motif; other site 637380008742 Walker B; other site 637380008743 D-loop; other site 637380008744 H-loop/switch region; other site 637380008745 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 637380008746 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637380008747 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380008748 Walker A/P-loop; other site 637380008749 ATP binding site [chemical binding]; other site 637380008750 Q-loop/lid; other site 637380008751 ABC transporter signature motif; other site 637380008752 Walker B; other site 637380008753 D-loop; other site 637380008754 H-loop/switch region; other site 637380008755 Uncharacterised protein family (UPF0154); Region: UPF0154; cl01536 637380008756 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 637380008757 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 637380008758 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 637380008759 TPP-binding site [chemical binding]; other site 637380008760 dimer interface [polypeptide binding]; other site 637380008761 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637380008762 PYR/PP interface [polypeptide binding]; other site 637380008763 dimer interface [polypeptide binding]; other site 637380008764 TPP binding site [chemical binding]; other site 637380008765 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637380008766 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 637380008767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380008768 dimer interface [polypeptide binding]; other site 637380008769 conserved gate region; other site 637380008770 ABC-ATPase subunit interface; other site 637380008771 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 637380008772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 637380008773 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 637380008774 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 637380008775 Walker A/P-loop; other site 637380008776 ATP binding site [chemical binding]; other site 637380008777 Q-loop/lid; other site 637380008778 ABC transporter signature motif; other site 637380008779 Walker B; other site 637380008780 D-loop; other site 637380008781 H-loop/switch region; other site 637380008782 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 637380008783 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 637380008784 membrane-bound complex binding site; other site 637380008785 hinge residues; other site 637380008786 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 637380008787 active site 637380008788 metal binding site [ion binding]; metal-binding site 637380008789 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637380008790 Transposase [DNA replication, recombination, and repair]; Region: COG5421 637380008791 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 637380008792 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 637380008793 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 637380008794 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 637380008795 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 637380008796 catalytic residues [active] 637380008797 catalytic nucleophile [active] 637380008798 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380008799 LexA repressor; Validated; Region: PRK00215 637380008800 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 637380008801 Catalytic site [active] 637380008802 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 637380008803 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380008804 Proteins of 100 residues with WXG; Region: WXG100; cl02005 637380008805 Phage Terminase; Region: Terminase_1; pfam03354 637380008806 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 637380008807 Phage Terminase; Region: Terminase_1; pfam03354 637380008808 glutamine synthetase, type I; Region: GlnA; TIGR00653 637380008809 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 637380008810 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 637380008811 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 637380008812 DNA binding residues [nucleotide binding] 637380008813 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 637380008814 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637380008815 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637380008816 catalytic residue [active] 637380008817 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 637380008818 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 637380008819 G1 box; other site 637380008820 GTP/Mg2+ binding site [chemical binding]; other site 637380008821 Switch I region; other site 637380008822 G2 box; other site 637380008823 G3 box; other site 637380008824 Switch II region; other site 637380008825 G4 box; other site 637380008826 G5 box; other site 637380008827 Predicted membrane protein [Function unknown]; Region: COG2860 637380008828 UPF0126 domain; Region: UPF0126; pfam03458 637380008829 UPF0126 domain; Region: UPF0126; pfam03458 637380008830 stage V sporulation protein K; Region: spore_V_K; TIGR02881 637380008831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380008832 Walker A motif; other site 637380008833 ATP binding site [chemical binding]; other site 637380008834 Walker B motif; other site 637380008835 arginine finger; other site 637380008836 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 637380008837 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 637380008838 DNA binding site [nucleotide binding] 637380008839 active site 637380008840 Int/Topo IB signature motif; other site 637380008841 catalytic residues [active] 637380008842 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 637380008843 Sm1 motif; other site 637380008844 intra - hexamer interaction site; other site 637380008845 inter - hexamer interaction site [polypeptide binding]; other site 637380008846 nucleotide binding pocket [chemical binding]; other site 637380008847 Sm2 motif; other site 637380008848 IPP transferase; Region: IPPT; cl00403 637380008849 Bacterial SH3 domain; Region: SH3_3; cl02551 637380008850 Bacterial SH3 domain; Region: SH3_3; cl02551 637380008851 3D domain; Region: 3D; cl01439 637380008852 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637380008853 active site 637380008854 phosphorylation site [posttranslational modification] 637380008855 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 637380008856 P-loop; other site 637380008857 active site 637380008858 phosphorylation site [posttranslational modification] 637380008859 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637380008860 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 637380008861 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 637380008862 putative substrate binding site [chemical binding]; other site 637380008863 putative ATP binding site [chemical binding]; other site 637380008864 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 637380008865 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380008866 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 637380008867 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 637380008868 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 637380008869 dimer interface [polypeptide binding]; other site 637380008870 active site 637380008871 metal binding site [ion binding]; metal-binding site 637380008872 Protein of unknown function (DUF420); Region: DUF420; cl00989 637380008873 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380008874 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18 (...; Region: GH18_chitinase_D-like; cd02871 637380008875 Glycosyl hydrolase family 18; Region: Glyco_18; smart00636 637380008876 putative active site [active] 637380008877 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 637380008878 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637380008879 putative active site [active] 637380008880 putative metal binding site [ion binding]; other site 637380008881 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 637380008882 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 637380008883 IHF dimer interface [polypeptide binding]; other site 637380008884 IHF - DNA interface [nucleotide binding]; other site 637380008885 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380008886 Coenzyme A binding pocket [chemical binding]; other site 637380008887 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 637380008888 metal-binding site [ion binding] 637380008889 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 637380008890 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 637380008891 metal-binding site [ion binding] 637380008892 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637380008893 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637380008894 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 637380008895 metal-binding site [ion binding] 637380008896 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 637380008897 putative homotetramer interface [polypeptide binding]; other site 637380008898 putative homodimer interface [polypeptide binding]; other site 637380008899 putative allosteric switch controlling residues; other site 637380008900 putative metal binding site [ion binding]; other site 637380008901 putative homodimer-homodimer interface [polypeptide binding]; other site 637380008902 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380008903 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 637380008904 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 637380008905 Walker A/P-loop; other site 637380008906 ATP binding site [chemical binding]; other site 637380008907 Q-loop/lid; other site 637380008908 ABC transporter signature motif; other site 637380008909 Walker B; other site 637380008910 D-loop; other site 637380008911 H-loop/switch region; other site 637380008912 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 637380008913 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 637380008914 ABC-ATPase subunit interface; other site 637380008915 dimer interface [polypeptide binding]; other site 637380008916 putative PBP binding regions; other site 637380008917 ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605 637380008918 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 637380008919 ABC-ATPase subunit interface; other site 637380008920 dimer interface [polypeptide binding]; other site 637380008921 putative PBP binding regions; other site 637380008922 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 637380008923 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: FeuA; cd01138 637380008924 putative ligand binding residues [chemical binding]; other site 637380008925 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 637380008926 active site 637380008927 DNA binding site [nucleotide binding] 637380008928 putative phosphate binding site [ion binding]; other site 637380008929 putative catalytic site [active] 637380008930 metal binding site A [ion binding]; metal-binding site 637380008931 AP binding site [nucleotide binding]; other site 637380008932 metal binding site B [ion binding]; metal-binding site 637380008933 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 637380008934 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 637380008935 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637380008936 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637380008937 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 637380008938 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 637380008939 DNA binding site [nucleotide binding] 637380008940 active site 637380008941 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 637380008942 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 637380008943 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 637380008944 minor groove reading motif; other site 637380008945 helix-hairpin-helix signature motif; other site 637380008946 substrate binding pocket [chemical binding]; other site 637380008947 active site 637380008948 peptidase T; Region: peptidase-T; TIGR01882 637380008949 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 637380008950 metal binding site [ion binding]; metal-binding site 637380008951 dimer interface [polypeptide binding]; other site 637380008952 Predicted membrane protein [Function unknown]; Region: COG2364 637380008953 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637380008954 hypothetical protein; Provisional; Region: PRK06764 637380008955 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637380008956 catalytic core [active] 637380008957 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637380008958 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 637380008959 active site 637380008960 metal binding site [ion binding]; metal-binding site 637380008961 PAS domain S-box; Region: sensory_box; TIGR00229 637380008962 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 637380008963 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637380008964 metal binding site [ion binding]; metal-binding site 637380008965 active site 637380008966 I-site; other site 637380008967 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637380008968 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 637380008969 Uncharacterised protein from bacillus cereus group; Region: YfmQ; pfam10787 637380008970 LrgA family; Region: LrgA; cl00608 637380008971 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 637380008972 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637380008973 DNA-binding site [nucleotide binding]; DNA binding site 637380008974 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637380008975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380008976 homodimer interface [polypeptide binding]; other site 637380008977 catalytic residue [active] 637380008978 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 637380008979 active site 637380008980 catalytic site [active] 637380008981 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 637380008982 putative active site [active] 637380008983 putative catalytic triad [active] 637380008984 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 637380008985 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 637380008986 putative peptidoglycan binding site; other site 637380008987 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 637380008988 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 637380008989 putative peptidoglycan binding site; other site 637380008990 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 637380008991 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 637380008992 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380008993 potential frameshift: common BLAST hit: gi|218904892|ref|YP_002452726.1| sulfatase 637380008994 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 637380008995 Sulfatase; Region: Sulfatase; cl10460 637380008996 Sulfatase; Region: Sulfatase; cl10460 637380008997 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 637380008998 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 637380008999 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 637380009000 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 637380009001 G3 box; other site 637380009002 Switch II region; other site 637380009003 GTP/Mg2+ binding site [chemical binding]; other site 637380009004 G4 box; other site 637380009005 G5 box; other site 637380009006 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 637380009007 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-...; Region: Ntn_PVA; cd00542 637380009008 active site 637380009009 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637380009010 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380009011 dimer interface [polypeptide binding]; other site 637380009012 phosphorylation site [posttranslational modification] 637380009013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380009014 ATP binding site [chemical binding]; other site 637380009015 Mg2+ binding site [ion binding]; other site 637380009016 G-X-G motif; other site 637380009017 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380009018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380009019 active site 637380009020 phosphorylation site [posttranslational modification] 637380009021 intermolecular recognition site; other site 637380009022 dimerization interface [polypeptide binding]; other site 637380009023 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380009024 DNA binding site [nucleotide binding] 637380009025 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637380009026 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 637380009027 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637380009028 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 637380009029 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 637380009030 Walker A/P-loop; other site 637380009031 ATP binding site [chemical binding]; other site 637380009032 Q-loop/lid; other site 637380009033 ABC transporter signature motif; other site 637380009034 Walker B; other site 637380009035 D-loop; other site 637380009036 H-loop/switch region; other site 637380009037 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 637380009038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380009039 ATP binding site [chemical binding]; other site 637380009040 Mg2+ binding site [ion binding]; other site 637380009041 G-X-G motif; other site 637380009042 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 637380009043 ATP binding site [chemical binding]; other site 637380009044 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 637380009045 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 637380009046 MutS domain I; Region: MutS_I; pfam01624 637380009047 MutS domain II; Region: MutS_II; pfam05188 637380009048 MutS family domain IV; Region: MutS_IV; pfam05190 637380009049 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 637380009050 Walker A/P-loop; other site 637380009051 ATP binding site [chemical binding]; other site 637380009052 Q-loop/lid; other site 637380009053 ABC transporter signature motif; other site 637380009054 Walker B; other site 637380009055 D-loop; other site 637380009056 H-loop/switch region; other site 637380009057 Outer spore coat protein E (CotE); Region: CotE; pfam10628 637380009058 Protein of unknown function (DUF964); Region: DUF964; cl01483 637380009059 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 637380009060 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 637380009061 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 637380009062 FeS/SAM binding site; other site 637380009063 TRAM domain; Region: TRAM; cl01282 637380009064 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 637380009065 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 637380009066 TPP-binding site [chemical binding]; other site 637380009067 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 637380009068 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 637380009069 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 637380009070 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 637380009071 dimer interface [polypeptide binding]; other site 637380009072 PYR/PP interface [polypeptide binding]; other site 637380009073 TPP binding site [chemical binding]; other site 637380009074 substrate binding site [chemical binding]; other site 637380009075 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637380009076 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics...; Region: rDP_like; cd01301 637380009077 active site 637380009078 dimer interface [polypeptide binding]; other site 637380009079 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 637380009080 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637380009081 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 637380009082 putative active site [active] 637380009083 metal binding site [ion binding]; metal-binding site 637380009084 homodimer binding site [polypeptide binding]; other site 637380009085 phosphodiesterase; Provisional; Region: PRK12704 637380009086 Outer membrane protein (OmpH-like); Region: OmpH; cl08146 637380009087 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 637380009088 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380009089 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380009090 Walker A motif; other site 637380009091 ATP binding site [chemical binding]; other site 637380009092 Walker B motif; other site 637380009093 competence damage-inducible protein A; Provisional; Region: PRK00549 637380009094 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 637380009095 putative MPT binding site; other site 637380009096 Competence-damaged protein; Region: CinA; cl00666 637380009097 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 637380009098 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 637380009099 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 637380009100 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 637380009101 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 637380009102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380009103 NAD(P) binding site [chemical binding]; other site 637380009104 active site 637380009105 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 637380009106 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 637380009107 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 637380009108 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 637380009109 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 637380009110 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 637380009111 TM-ABC transporter signature motif; other site 637380009112 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 637380009113 TM-ABC transporter signature motif; other site 637380009114 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 637380009115 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 637380009116 Walker A/P-loop; other site 637380009117 ATP binding site [chemical binding]; other site 637380009118 Q-loop/lid; other site 637380009119 ABC transporter signature motif; other site 637380009120 Walker B; other site 637380009121 D-loop; other site 637380009122 H-loop/switch region; other site 637380009123 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 637380009124 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 637380009125 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 637380009126 ligand binding site [chemical binding]; other site 637380009127 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 637380009128 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637380009129 DNA-binding site [nucleotide binding]; DNA binding site 637380009130 UTRA domain; Region: UTRA; cl06649 637380009131 Tetraspanin family; Region: Tetraspannin; pfam00335 637380009132 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 637380009133 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380009134 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 637380009135 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl14780 637380009136 active site 637380009137 potential frameshift: common BLAST hit: gi|227813294|ref|YP_002813303.1| metallo-beta-lactamase family protein 637380009138 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 637380009139 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 637380009140 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380009141 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 637380009142 dihydrodipicolinate synthase; Region: dapA; TIGR00674 637380009143 dimer interface [polypeptide binding]; other site 637380009144 active site 637380009145 catalytic residue [active] 637380009146 aspartate kinase I; Reviewed; Region: PRK08210 637380009147 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 637380009148 nucleotide binding site [chemical binding]; other site 637380009149 substrate binding site [chemical binding]; other site 637380009150 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 637380009151 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 637380009152 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 637380009153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380009154 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 637380009155 Flavoprotein; Region: Flavoprotein; cl08021 637380009156 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 637380009157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380009158 NAD(P) binding pocket [chemical binding]; other site 637380009159 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 637380009160 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 637380009161 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 637380009162 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 637380009163 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 637380009164 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 637380009165 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 637380009166 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 637380009167 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 637380009168 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 637380009169 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 637380009170 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 637380009171 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 637380009172 putative nucleic acid binding region [nucleotide binding]; other site 637380009173 G-X-X-G motif; other site 637380009174 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 637380009175 RNA binding site [nucleotide binding]; other site 637380009176 domain interface; other site 637380009177 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 637380009178 16S/18S rRNA binding site [nucleotide binding]; other site 637380009179 S13e-L30e interaction site [polypeptide binding]; other site 637380009180 25S rRNA binding site [nucleotide binding]; other site 637380009181 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 637380009182 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 637380009183 active site 637380009184 Riboflavin kinase; Region: Flavokinase; pfam01687 637380009185 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 637380009186 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 637380009187 RNA binding site [nucleotide binding]; other site 637380009188 active site 637380009189 Ribosome-binding factor A; Region: RBFA; cl00542 637380009190 Protein of unknown function (DUF503); Region: DUF503; cl00669 637380009191 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 637380009192 translation initiation factor IF-2; Region: IF-2; TIGR00487 637380009193 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 637380009194 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 637380009195 G1 box; other site 637380009196 putative GEF interaction site [polypeptide binding]; other site 637380009197 GTP/Mg2+ binding site [chemical binding]; other site 637380009198 Switch I region; other site 637380009199 G2 box; other site 637380009200 G3 box; other site 637380009201 Switch II region; other site 637380009202 G4 box; other site 637380009203 G5 box; other site 637380009204 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 637380009205 Translation-initiation factor 2; Region: IF-2; pfam11987 637380009206 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 637380009207 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 637380009208 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 637380009209 putative RNA binding cleft [nucleotide binding]; other site 637380009210 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 637380009211 NusA N-terminal domain; Region: NusA_N; pfam08529 637380009212 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 637380009213 RNA binding site [nucleotide binding]; other site 637380009214 homodimer interface [polypeptide binding]; other site 637380009215 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 637380009216 G-X-X-G motif; other site 637380009217 ribosome maturation protein RimP; Reviewed; Region: PRK00092 637380009218 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 637380009219 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 637380009220 Sm1 motif; other site 637380009221 predicted subunit interaction site [polypeptide binding]; other site 637380009222 RNA binding pocket [nucleotide binding]; other site 637380009223 Sm2 motif; other site 637380009224 DNA polymerase III PolC; Validated; Region: polC; PRK00448 637380009225 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 637380009226 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 637380009227 generic binding surface II; other site 637380009228 generic binding surface I; other site 637380009229 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 637380009230 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 637380009231 active site 637380009232 substrate binding site [chemical binding]; other site 637380009233 catalytic site [active] 637380009234 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 637380009235 prolyl-tRNA synthetase; Provisional; Region: PRK09194 637380009236 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 637380009237 dimer interface [polypeptide binding]; other site 637380009238 motif 1; other site 637380009239 active site 637380009240 motif 2; other site 637380009241 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 637380009242 putative deacylase active site [active] 637380009243 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 637380009244 active site 637380009245 motif 3; other site 637380009246 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 637380009247 anticodon binding site; other site 637380009248 RIP metalloprotease RseP; Region: TIGR00054 637380009249 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 637380009250 active site 637380009251 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 637380009252 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 637380009253 protein binding site [polypeptide binding]; other site 637380009254 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 637380009255 putative substrate binding region [chemical binding]; other site 637380009256 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 637380009257 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 637380009258 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 637380009259 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 637380009260 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 637380009261 catalytic residue [active] 637380009262 putative FPP diphosphate binding site; other site 637380009263 putative FPP binding hydrophobic cleft; other site 637380009264 dimer interface [polypeptide binding]; other site 637380009265 putative IPP diphosphate binding site; other site 637380009266 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 637380009267 hinge region; other site 637380009268 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 637380009269 putative nucleotide binding site [chemical binding]; other site 637380009270 uridine monophosphate binding site [chemical binding]; other site 637380009271 homohexameric interface [polypeptide binding]; other site 637380009272 elongation factor Ts; Provisional; Region: tsf; PRK09377 637380009273 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 637380009274 Elongation factor TS; Region: EF_TS; pfam00889 637380009275 Elongation factor TS; Region: EF_TS; pfam00889 637380009276 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 637380009277 rRNA interaction site [nucleotide binding]; other site 637380009278 S8 interaction site; other site 637380009279 putative laminin-1 binding site; other site 637380009280 transcriptional repressor CodY; Validated; Region: PRK04158 637380009281 CodY GAF-like domain; Region: CodY; pfam06018 637380009282 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 637380009283 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 637380009284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380009285 Walker A motif; other site 637380009286 ATP binding site [chemical binding]; other site 637380009287 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380009288 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 637380009289 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 637380009290 active site 637380009291 HslU subunit interaction site [polypeptide binding]; other site 637380009292 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 637380009293 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798 637380009294 Int/Topo IB signature motif; other site 637380009295 active site 637380009296 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 637380009297 Glucose inhibited division protein A; Region: GIDA; pfam01134 637380009298 DNA topoisomerase I; Validated; Region: PRK05582 637380009299 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 637380009300 active site 637380009301 interdomain interaction site; other site 637380009302 putative metal-binding site [ion binding]; other site 637380009303 nucleotide binding site [chemical binding]; other site 637380009304 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 637380009305 domain I; other site 637380009306 DNA binding groove [nucleotide binding] 637380009307 phosphate binding site [ion binding]; other site 637380009308 domain II; other site 637380009309 domain III; other site 637380009310 nucleotide binding site [chemical binding]; other site 637380009311 catalytic site [active] 637380009312 domain IV; other site 637380009313 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 637380009314 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 637380009315 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 637380009316 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 637380009317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380009318 CoA-ligase; Region: Ligase_CoA; pfam00549 637380009319 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 637380009320 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 637380009321 CoA-ligase; Region: Ligase_CoA; pfam00549 637380009322 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 637380009323 RNA/DNA hybrid binding site [nucleotide binding]; other site 637380009324 active site 637380009325 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 637380009326 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases...; Region: YlqF; cd01856 637380009327 GTP/Mg2+ binding site [chemical binding]; other site 637380009328 G4 box; other site 637380009329 G5 box; other site 637380009330 G1 box; other site 637380009331 Switch I region; other site 637380009332 G2 box; other site 637380009333 G3 box; other site 637380009334 Switch II region; other site 637380009335 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 637380009336 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637380009337 Catalytic site [active] 637380009338 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637380009339 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 637380009340 BACI_c37920; ribosomal protein L19 leader, RF00556 637380009341 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 637380009342 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 637380009343 RimM N-terminal domain; Region: RimM; pfam01782 637380009344 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 637380009345 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 637380009346 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 637380009347 signal recognition particle protein; Provisional; Region: PRK10867 637380009348 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 637380009349 P loop; other site 637380009350 GTP binding site [chemical binding]; other site 637380009351 Signal peptide binding domain; Region: SRP_SPB; pfam02978 637380009352 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 637380009353 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 637380009354 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 637380009355 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 637380009356 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 637380009357 P loop; other site 637380009358 GTP binding site [chemical binding]; other site 637380009359 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 637380009360 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 637380009361 Walker A/P-loop; other site 637380009362 ATP binding site [chemical binding]; other site 637380009363 Q-loop/lid; other site 637380009364 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 637380009365 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 637380009366 ABC transporter signature motif; other site 637380009367 Walker B; other site 637380009368 D-loop; other site 637380009369 H-loop/switch region; other site 637380009370 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 637380009371 dsRNA binding site [nucleotide binding]; other site 637380009372 Phosphopantetheine attachment site; Region: PP-binding; cl09936 637380009373 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 637380009374 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 637380009375 NAD(P) binding site [chemical binding]; other site 637380009376 homotetramer interface [polypeptide binding]; other site 637380009377 homodimer interface [polypeptide binding]; other site 637380009378 active site 637380009379 Acyl transferase domain; Region: Acyl_transf_1; cl08282 637380009380 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 637380009381 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 637380009382 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 637380009383 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 637380009384 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 637380009385 generic binding surface II; other site 637380009386 ssDNA binding site; other site 637380009387 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637380009388 ATP binding site [chemical binding]; other site 637380009389 putative Mg++ binding site [ion binding]; other site 637380009390 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637380009391 nucleotide binding region [chemical binding]; other site 637380009392 ATP-binding site [chemical binding]; other site 637380009393 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 637380009394 DAK2 domain; Region: Dak2; cl03685 637380009395 Protein of unknown function (DUF322); Region: DUF322; cl00574 637380009396 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 637380009397 Thiamine pyrophosphokinase; Region: TPK; cd07995 637380009398 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 637380009399 active site 637380009400 dimerization interface [polypeptide binding]; other site 637380009401 thiamine binding site [chemical binding]; other site 637380009402 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 637380009403 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 637380009404 substrate binding site [chemical binding]; other site 637380009405 hexamer interface [polypeptide binding]; other site 637380009406 metal binding site [ion binding]; metal-binding site 637380009407 GTPase RsgA; Reviewed; Region: PRK00098 637380009408 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 637380009409 GTPase/OB domain interface [polypeptide binding]; other site 637380009410 GTPase/Zn-binding domain interface [polypeptide binding]; other site 637380009411 GTP/Mg2+ binding site [chemical binding]; other site 637380009412 G4 box; other site 637380009413 G5 box; other site 637380009414 G1 box; other site 637380009415 Switch I region; other site 637380009416 G2 box; other site 637380009417 G3 box; other site 637380009418 Switch II region; other site 637380009419 Catalytic domain of Protein Kinases; Region: PKc; cd00180 637380009420 active site 637380009421 ATP binding site [chemical binding]; other site 637380009422 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 637380009423 substrate binding site [chemical binding]; other site 637380009424 activation loop (A-loop); other site 637380009425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 637380009426 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 637380009427 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 637380009428 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 637380009429 Protein phosphatase 2C; Region: PP2C; pfam00481 637380009430 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 637380009431 Active site [active] 637380009432 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 637380009433 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 637380009434 FeS/SAM binding site; other site 637380009435 16S rRNA methyltransferase B; Provisional; Region: PRK14902 637380009436 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 637380009437 putative RNA binding site [nucleotide binding]; other site 637380009438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380009439 S-adenosylmethionine binding site [chemical binding]; other site 637380009440 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 637380009441 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 637380009442 putative active site [active] 637380009443 substrate binding site [chemical binding]; other site 637380009444 putative cosubstrate binding site; other site 637380009445 catalytic site [active] 637380009446 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 637380009447 substrate binding site [chemical binding]; other site 637380009448 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 637380009449 active site 637380009450 catalytic residues [active] 637380009451 metal binding site [ion binding]; metal-binding site 637380009452 primosome assembly protein PriA; Validated; Region: PRK05580 637380009453 primosome assembly protein PriA; Validated; Region: PRK05580 637380009454 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637380009455 ATP binding site [chemical binding]; other site 637380009456 putative Mg++ binding site [ion binding]; other site 637380009457 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 637380009458 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 637380009459 Flavoprotein; Region: Flavoprotein; cl08021 637380009460 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 637380009461 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 637380009462 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 637380009463 catalytic site [active] 637380009464 G-X2-G-X-G-K; other site 637380009465 Domain of unknown function (DUF370); Region: DUF370; cl00898 637380009466 hypothetical protein; Provisional; Region: PRK11820 637380009467 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 637380009468 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 637380009469 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 637380009470 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 637380009471 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637380009472 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637380009473 motif II; other site 637380009474 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 637380009475 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 637380009476 Domain of unknown function (DUF814); Region: DUF814; pfam05670 637380009477 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 637380009478 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 637380009479 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 637380009480 active site 637380009481 DinB superfamily; Region: DinB_2; cl00986 637380009482 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380009483 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 637380009484 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 637380009485 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 637380009486 active site 637380009487 dimer interface [polypeptide binding]; other site 637380009488 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 637380009489 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 637380009490 heterodimer interface [polypeptide binding]; other site 637380009491 active site 637380009492 FMN binding site [chemical binding]; other site 637380009493 homodimer interface [polypeptide binding]; other site 637380009494 substrate binding site [chemical binding]; other site 637380009495 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 637380009496 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 637380009497 FAD binding pocket [chemical binding]; other site 637380009498 FAD binding motif [chemical binding]; other site 637380009499 phosphate binding motif [ion binding]; other site 637380009500 beta-alpha-beta structure motif; other site 637380009501 NAD binding pocket [chemical binding]; other site 637380009502 Iron coordination center [ion binding]; other site 637380009503 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 637380009504 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 637380009505 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 637380009506 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 637380009507 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 637380009508 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 637380009509 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 637380009510 IMP binding site; other site 637380009511 dimer interface [polypeptide binding]; other site 637380009512 interdomain contacts; other site 637380009513 partial ornithine binding site; other site 637380009514 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 637380009515 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 637380009516 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 637380009517 catalytic site [active] 637380009518 subunit interface [polypeptide binding]; other site 637380009519 dihydroorotase; Validated; Region: pyrC; PRK09357 637380009520 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 637380009521 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 637380009522 active site 637380009523 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 637380009524 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 637380009525 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 637380009526 Sulfate transporter family; Region: Sulfate_transp; cl00967 637380009527 Permease family; Region: Xan_ur_permease; pfam00860 637380009528 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 637380009529 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 637380009530 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637380009531 RNA binding surface [nucleotide binding]; other site 637380009532 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 637380009533 active site 637380009534 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 637380009535 lipoprotein signal peptidase; Provisional; Region: PRK14787 637380009536 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 637380009537 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 637380009538 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 637380009539 active site 637380009540 HIGH motif; other site 637380009541 nucleotide binding site [chemical binding]; other site 637380009542 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 637380009543 active site 637380009544 KMSKS motif; other site 637380009545 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 637380009546 tRNA binding surface [nucleotide binding]; other site 637380009547 anticodon binding site; other site 637380009548 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 637380009549 DivIVA protein; Region: DivIVA; pfam05103 637380009550 DivIVA domain; Region: DivI1A_domain; TIGR03544 637380009551 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 637380009552 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 637380009553 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637380009554 RNA binding surface [nucleotide binding]; other site 637380009555 YGGT family; Region: YGGT; cl00508 637380009556 Protein of unknown function (DUF552); Region: DUF552; cl00775 637380009557 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 637380009558 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637380009559 catalytic residue [active] 637380009560 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 637380009561 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 637380009562 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 637380009563 sporulation sigma factor SigG; Reviewed; Region: PRK08215 637380009564 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637380009565 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 637380009566 DNA binding residues [nucleotide binding] 637380009567 sporulation sigma factor SigE; Reviewed; Region: PRK08301 637380009568 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637380009569 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 637380009570 DNA binding residues [nucleotide binding] 637380009571 Sporulation factor SpoIIGA; Region: Peptidase_U4; cl04058 637380009572 cell division protein FtsZ; Validated; Region: PRK09330 637380009573 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 637380009574 nucleotide binding site [chemical binding]; other site 637380009575 SulA interaction site; other site 637380009576 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 637380009577 Cell division protein FtsA; Region: FtsA; cl11496 637380009578 Cell division protein FtsA; Region: FtsA; cl11496 637380009579 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 637380009580 Cell division protein FtsQ; Region: FtsQ; pfam03799 637380009581 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 637380009582 FAD binding domain; Region: FAD_binding_4; pfam01565 637380009583 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 637380009584 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 637380009585 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 637380009586 active site 637380009587 homodimer interface [polypeptide binding]; other site 637380009588 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 637380009589 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380009590 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 637380009591 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637380009592 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637380009593 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 637380009594 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 637380009595 Mg++ binding site [ion binding]; other site 637380009596 putative catalytic motif [active] 637380009597 putative substrate binding site [chemical binding]; other site 637380009598 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 637380009599 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 637380009600 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637380009601 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637380009602 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 637380009603 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637380009604 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 637380009605 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 637380009606 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 637380009607 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637380009608 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 637380009609 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 637380009610 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 637380009611 Septum formation initiator; Region: DivIC; cl11433 637380009612 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 637380009613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380009614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 637380009615 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 637380009616 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 637380009617 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380009618 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 637380009619 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380009620 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 637380009621 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 637380009622 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 637380009623 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 637380009624 hypothetical protein; Provisional; Region: PRK13670 637380009625 hypothetical protein; Provisional; Region: PRK13671 637380009626 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 637380009627 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 637380009628 protein binding site [polypeptide binding]; other site 637380009629 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 637380009630 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 637380009631 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 637380009632 active site 637380009633 nucleophile elbow; other site 637380009634 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 637380009635 Nucleoside recognition; Region: Gate; cl00486 637380009636 Nucleoside recognition; Region: Gate; cl00486 637380009637 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 637380009638 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 637380009639 active site 637380009640 (T/H)XGH motif; other site 637380009641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380009642 BACI_c38870; ylbH leader, RF00516 637380009643 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 637380009644 Protein of unknown function (DUF964); Region: DUF964; cl01483 637380009645 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637380009646 catalytic core [active] 637380009647 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 637380009648 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 637380009649 YugN-like family; Region: YugN; pfam08868 637380009650 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 637380009651 multimer interface [polypeptide binding]; other site 637380009652 active site 637380009653 catalytic triad [active] 637380009654 dimer interface [polypeptide binding]; other site 637380009655 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 637380009656 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 637380009657 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 637380009658 Subunit I/III interface [polypeptide binding]; other site 637380009659 Subunit III/IV interface [polypeptide binding]; other site 637380009660 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 637380009661 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 637380009662 D-pathway; other site 637380009663 Putative ubiquinol binding site [chemical binding]; other site 637380009664 Low-spin heme (heme b) binding site [chemical binding]; other site 637380009665 Putative water exit pathway; other site 637380009666 Binuclear center (heme o3/CuB) [ion binding]; other site 637380009667 K-pathway; other site 637380009668 Putative proton exit pathway; other site 637380009669 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 637380009670 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 637380009671 Cytochrome c; Region: Cytochrom_C; cl11414 637380009672 UbiA prenyltransferase family; Region: UbiA; cl00337 637380009673 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 637380009674 cytochrome c oxidase assembly protein; Provisional; Region: PTZ00127 637380009675 pyruvate carboxylase; Reviewed; Region: PRK12999 637380009676 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 637380009677 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 637380009678 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 637380009679 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 637380009680 active site 637380009681 catalytic residues [active] 637380009682 metal binding site [ion binding]; metal-binding site 637380009683 homodimer binding site [polypeptide binding]; other site 637380009684 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 637380009685 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 637380009686 carboxyltransferase (CT) interaction site; other site 637380009687 biotinylation site [posttranslational modification]; other site 637380009688 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 637380009689 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 637380009690 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 637380009691 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 637380009692 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 637380009693 putative active site [active] 637380009694 PhoH-like protein; Region: PhoH; cl12134 637380009695 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 637380009696 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 637380009697 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 637380009698 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 637380009699 G1 box; other site 637380009700 putative GEF interaction site [polypeptide binding]; other site 637380009701 GTP/Mg2+ binding site [chemical binding]; other site 637380009702 Switch I region; other site 637380009703 G2 box; other site 637380009704 G3 box; other site 637380009705 Switch II region; other site 637380009706 G4 box; other site 637380009707 G5 box; other site 637380009708 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 637380009709 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 637380009710 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1,6-; Region: IMPase_like; cd01637 637380009711 active site 637380009712 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 637380009713 Uncharacterised protein family (UPF0223); Region: UPF0223; cl11484 637380009714 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 637380009715 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and...; Region: Orn_deC_like; cd00615 637380009716 homodimer interface [polypeptide binding]; other site 637380009717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380009718 catalytic residue [active] 637380009719 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 637380009720 transglutaminase; Provisional; Region: tgl; PRK03187 637380009721 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 637380009722 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 637380009723 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 637380009724 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380009725 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 637380009726 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 637380009727 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 637380009728 E3 interaction surface; other site 637380009729 lipoyl attachment site [posttranslational modification]; other site 637380009730 e3 binding domain; Region: E3_binding; pfam02817 637380009731 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 637380009732 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 637380009733 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 637380009734 alpha subunit interface [polypeptide binding]; other site 637380009735 TPP binding site [chemical binding]; other site 637380009736 heterodimer interface [polypeptide binding]; other site 637380009737 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637380009738 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 637380009739 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 637380009740 TPP-binding site [chemical binding]; other site 637380009741 heterodimer interface [polypeptide binding]; other site 637380009742 tetramer interface [polypeptide binding]; other site 637380009743 phosphorylation loop region [posttranslational modification] 637380009744 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 637380009745 active site 637380009746 catalytic residues [active] 637380009747 metal binding site [ion binding]; metal-binding site 637380009748 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637380009749 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637380009750 active site 637380009751 motif I; other site 637380009752 motif II; other site 637380009753 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637380009754 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 637380009755 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 637380009756 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380009757 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 637380009758 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 637380009759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380009760 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380009761 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 637380009762 M28, and M42; Region: Zinc_peptidase_like; cl14876 637380009763 metal binding site [ion binding]; metal-binding site 637380009764 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapD_N; pfam08503 637380009765 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 637380009766 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA...; Region: LbH_THP_succinylT; cd03350 637380009767 trimer interface [polypeptide binding]; other site 637380009768 active site 637380009769 substrate binding site [chemical binding]; other site 637380009770 CoA binding site [chemical binding]; other site 637380009771 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637380009772 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380009773 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637380009774 dimerization interface [polypeptide binding]; other site 637380009775 FOG: CBS domain [General function prediction only]; Region: COG0517 637380009776 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_30; cd04643 637380009777 Protein of unknown function (DUF458); Region: DUF458; cl00861 637380009778 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 637380009779 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 637380009780 catalytic residues [active] 637380009781 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637380009782 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 637380009783 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 637380009784 short chain dehydrogenase; Provisional; Region: PRK07677 637380009785 NAD(P) binding site [chemical binding]; other site 637380009786 substrate binding site [chemical binding]; other site 637380009787 homotetramer interface [polypeptide binding]; other site 637380009788 active site 637380009789 homodimer interface [polypeptide binding]; other site 637380009790 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 637380009791 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637380009792 putative active site [active] 637380009793 putative metal binding site [ion binding]; other site 637380009794 potential frameshift: common BLAST hit: gi|118479202|ref|YP_896353.1| polyphosphate kinase 637380009795 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 637380009796 putative active site [active] 637380009797 catalytic site [active] 637380009798 Polyphosphate kinase; Region: PP_kinase; pfam02503 637380009799 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 637380009800 putative domain interface [polypeptide binding]; other site 637380009801 putative active site [active] 637380009802 catalytic site [active] 637380009803 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 637380009804 exopolyphosphatase; Region: exo_poly_only; TIGR03706 637380009805 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 637380009806 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 637380009807 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637380009808 I-site; other site 637380009809 active site 637380009810 metal binding site [ion binding]; metal-binding site 637380009811 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637380009812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380009813 putative substrate translocation pore; other site 637380009814 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380009815 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 637380009816 N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312 637380009817 THF binding site; other site 637380009818 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 637380009819 substrate binding site [chemical binding]; other site 637380009820 THF binding site; other site 637380009821 zinc-binding site [ion binding]; other site 637380009822 Competence protein J (ComJ); Region: ComJ; pfam11033 637380009823 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637380009824 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380009825 dimer interface [polypeptide binding]; other site 637380009826 phosphorylation site [posttranslational modification] 637380009827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380009828 ATP binding site [chemical binding]; other site 637380009829 Mg2+ binding site [ion binding]; other site 637380009830 G-X-G motif; other site 637380009831 aspartate aminotransferase; Provisional; Region: PRK08361 637380009832 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637380009833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380009834 homodimer interface [polypeptide binding]; other site 637380009835 catalytic residue [active] 637380009836 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637380009837 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637380009838 DNA binding site [nucleotide binding] 637380009839 domain linker motif; other site 637380009840 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 637380009841 putative dimerization interface [polypeptide binding]; other site 637380009842 putative ligand binding site [chemical binding]; other site 637380009843 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637380009844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380009845 dimer interface [polypeptide binding]; other site 637380009846 conserved gate region; other site 637380009847 putative PBP binding loops; other site 637380009848 ABC-ATPase subunit interface; other site 637380009849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380009850 dimer interface [polypeptide binding]; other site 637380009851 conserved gate region; other site 637380009852 putative PBP binding loops; other site 637380009853 ABC-ATPase subunit interface; other site 637380009854 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 637380009855 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380009856 CD and pullulan-degrading enzymes N-terminus domain. Members of this subgroup include: Cyclomaltodextrinase (CDase), maltogenic amylase, and neopullulanase all of which are capable of hydrolyzing all or two of the following three types of substrates:...; Region: CD_pullulan_degrading_enzymes_N_term; cd02857 637380009857 maltodextrin glucosidase; Provisional; Region: PRK10785 637380009858 homodimer; other site 637380009859 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 637380009860 Transposase domain (DUF772); Region: DUF772; cl12084 637380009861 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 637380009862 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 637380009863 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 637380009864 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 637380009865 Walker A/P-loop; other site 637380009866 ATP binding site [chemical binding]; other site 637380009867 Q-loop/lid; other site 637380009868 ABC transporter signature motif; other site 637380009869 Walker B; other site 637380009870 D-loop; other site 637380009871 H-loop/switch region; other site 637380009872 TOBE domain; Region: TOBE_2; cl01440 637380009873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380009874 NAD(P) binding site [chemical binding]; other site 637380009875 RDD family; Region: RDD; cl00746 637380009876 Predicted ATPase [General function prediction only]; Region: COG3910 637380009877 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380009878 Walker A/P-loop; other site 637380009879 ATP binding site [chemical binding]; other site 637380009880 Q-loop/lid; other site 637380009881 ABC transporter signature motif; other site 637380009882 Walker B; other site 637380009883 D-loop; other site 637380009884 H-loop/switch region; other site 637380009885 putative acyltransferase; Provisional; Region: PRK05790 637380009886 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 637380009887 dimer interface [polypeptide binding]; other site 637380009888 active site 637380009889 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 637380009890 nudix motif; other site 637380009891 hypothetical protein; Validated; Region: PRK07668 637380009892 hypothetical protein; Validated; Region: PRK07668 637380009893 hypothetical protein; Validated; Region: PRK07668 637380009894 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380009895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380009896 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 637380009897 NAD(P) binding site [chemical binding]; other site 637380009898 active site 637380009899 YvrJ protein family; Region: YvrJ; pfam12841 637380009900 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 637380009901 Initiation factor 2 subunit family; Region: IF-2B; pfam01008 637380009902 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637380009903 Predicted amidohydrolase [General function prediction only]; Region: COG0388 637380009904 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 637380009905 putative active site [active] 637380009906 catalytic triad [active] 637380009907 putative dimer interface [polypeptide binding]; other site 637380009908 aspartate aminotransferase; Provisional; Region: PRK07681 637380009909 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637380009910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380009911 homodimer interface [polypeptide binding]; other site 637380009912 catalytic residue [active] 637380009913 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 637380009914 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 637380009915 dimer interface [polypeptide binding]; other site 637380009916 active site 637380009917 catalytic residue [active] 637380009918 metal binding site [ion binding]; metal-binding site 637380009919 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637380009920 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 637380009921 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 637380009922 intersubunit interface [polypeptide binding]; other site 637380009923 active site 637380009924 Zn2+ binding site [ion binding]; other site 637380009925 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 637380009926 Cupin domain; Region: Cupin_2; cl09118 637380009927 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 637380009928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380009929 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637380009930 metal binding site [ion binding]; metal-binding site 637380009931 active site 637380009932 I-site; other site 637380009933 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 637380009934 dimer interface [polypeptide binding]; other site 637380009935 FMN binding site [chemical binding]; other site 637380009936 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 637380009937 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 637380009938 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 637380009939 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 637380009940 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 637380009941 dimerization domain swap beta strand [polypeptide binding]; other site 637380009942 regulatory protein interface [polypeptide binding]; other site 637380009943 active site 637380009944 regulatory phosphorylation site [posttranslational modification]; other site 637380009945 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637380009946 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 637380009947 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 637380009948 active site turn [active] 637380009949 phosphorylation site [posttranslational modification] 637380009950 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cd00210 637380009951 HPr interaction site; other site 637380009952 glycerol kinase (GK) interaction site [polypeptide binding]; other site 637380009953 active site 637380009954 phosphorylation site [posttranslational modification] 637380009955 transcriptional antiterminator BglG; Provisional; Region: PRK09772 637380009956 CAT RNA binding domain; Region: CAT_RBD; pfam03123 637380009957 PRD domain; Region: PRD; pfam00874 637380009958 PRD domain; Region: PRD; pfam00874 637380009959 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637380009960 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637380009961 active site 637380009962 motif I; other site 637380009963 motif II; other site 637380009964 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637380009965 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637380009966 DNA-binding site [nucleotide binding]; DNA binding site 637380009967 UTRA domain; Region: UTRA; cl06649 637380009968 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 637380009969 active site 637380009970 trimer interface [polypeptide binding]; other site 637380009971 allosteric site; other site 637380009972 active site lid [active] 637380009973 hexamer (dimer of trimers) interface [polypeptide binding]; other site 637380009974 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 637380009975 active site 637380009976 dimer interface [polypeptide binding]; other site 637380009977 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380009978 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 637380009979 ScpA/B protein; Region: ScpA_ScpB; cl00598 637380009980 Domain of unknown function (DUF309); Region: DUF309; cl00667 637380009981 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380009982 Coenzyme A binding pocket [chemical binding]; other site 637380009983 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 637380009984 active site 637380009985 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 637380009986 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637380009987 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637380009988 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637380009989 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 637380009990 SpoVA protein; Region: SpoVA; cl04298 637380009991 stage V sporulation protein AD; Validated; Region: PRK08304 637380009992 SpoVA protein; Region: SpoVA; cl04298 637380009993 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 637380009994 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 637380009995 sporulation sigma factor SigF; Validated; Region: PRK05572 637380009996 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637380009997 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 637380009998 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 637380009999 DNA binding residues [nucleotide binding] 637380010000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380010001 ATP binding site [chemical binding]; other site 637380010002 Mg2+ binding site [ion binding]; other site 637380010003 G-X-G motif; other site 637380010004 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 637380010005 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 637380010006 Beta-lactamase; Region: Beta-lactamase; cl01009 637380010007 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 637380010008 Predicted transcriptional regulators [Transcription]; Region: COG1725 637380010009 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637380010010 DNA-binding site [nucleotide binding]; DNA binding site 637380010011 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637380010012 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 637380010013 Walker A/P-loop; other site 637380010014 ATP binding site [chemical binding]; other site 637380010015 Q-loop/lid; other site 637380010016 ABC transporter signature motif; other site 637380010017 Walker B; other site 637380010018 D-loop; other site 637380010019 H-loop/switch region; other site 637380010020 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380010021 Protein of unknown function (DUF541); Region: SIMPL; cl01077 637380010022 Sulfate transporter family; Region: Sulfate_transp; cl00967 637380010023 Transposase domain (DUF772); Region: DUF772; cl12084 637380010024 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 637380010025 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 637380010026 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 637380010027 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 637380010028 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 637380010029 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 637380010030 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 637380010031 Sulfatase; Region: Sulfatase; cl10460 637380010032 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 637380010033 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798 637380010034 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 637380010035 Int/Topo IB signature motif; other site 637380010036 active site 637380010037 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 637380010038 metal binding site 2 [ion binding]; metal-binding site 637380010039 putative DNA binding helix; other site 637380010040 metal binding site 1 [ion binding]; metal-binding site 637380010041 dimer interface [polypeptide binding]; other site 637380010042 structural Zn2+ binding site [ion binding]; other site 637380010043 Integral membrane protein DUF95; Region: DUF95; cl00572 637380010044 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380010045 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380010046 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 637380010047 dimer interface [polypeptide binding]; other site 637380010048 ADP-ribose binding site [chemical binding]; other site 637380010049 active site 637380010050 nudix motif; other site 637380010051 metal binding site [ion binding]; metal-binding site 637380010052 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 637380010053 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 637380010054 active site 637380010055 catalytic tetrad [active] 637380010056 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 637380010057 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637380010058 active site 637380010059 catalytic tetrad [active] 637380010060 Uncharacterised protein family (UPF0157); Region: UPF0157; cl00987 637380010061 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 637380010062 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 637380010063 putative active site [active] 637380010064 putative metal binding site [ion binding]; other site 637380010065 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 637380010066 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 637380010067 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380010068 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637380010069 Predicted permease [General function prediction only]; Region: COG2056 637380010070 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380010071 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637380010072 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637380010073 DNA binding site [nucleotide binding] 637380010074 domain linker motif; other site 637380010075 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 637380010076 potential frameshift: common BLAST hit: gi|52141388|ref|YP_085441.1| acetyltransferase 637380010077 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380010078 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 637380010079 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 637380010080 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 637380010081 potential frameshift: common BLAST hit: gi|227816888|ref|YP_002816897.1| riboflavin biosynthesis protein RibD 637380010082 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 637380010083 catalytic motif [active] 637380010084 Zn binding site [ion binding]; other site 637380010085 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 637380010086 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 637380010087 Lumazine binding domain; Region: Lum_binding; pfam00677 637380010088 Lumazine binding domain; Region: Lum_binding; pfam00677 637380010089 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 637380010090 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 637380010091 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 637380010092 dimerization interface [polypeptide binding]; other site 637380010093 active site 637380010094 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 637380010095 homopentamer interface [polypeptide binding]; other site 637380010096 active site 637380010097 biotin synthase; Validated; Region: PRK06256 637380010098 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 637380010099 FeS/SAM binding site; other site 637380010100 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 637380010101 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 637380010102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380010103 S-adenosylmethionine binding site [chemical binding]; other site 637380010104 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637380010105 Protein of unknown function (DUF452); Region: DUF452; cl01062 637380010106 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 637380010107 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 637380010108 substrate-cofactor binding pocket; other site 637380010109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380010110 catalytic residue [active] 637380010111 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 637380010112 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 637380010113 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 637380010114 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 637380010115 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 637380010116 inhibitor-cofactor binding pocket; inhibition site 637380010117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380010118 catalytic residue [active] 637380010119 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 637380010120 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380010121 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380010122 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 637380010123 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 637380010124 active site 637380010125 metal binding site [ion binding]; metal-binding site 637380010126 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 637380010127 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 637380010128 active site 637380010129 catalytic triad [active] 637380010130 oxyanion hole [active] 637380010131 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380010132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 637380010133 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 637380010134 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 637380010135 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 637380010136 inhibitor-cofactor binding pocket; inhibition site 637380010137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380010138 catalytic residue [active] 637380010139 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 637380010140 nucleotide binding site [chemical binding]; other site 637380010141 N-acetyl-L-glutamate binding site [chemical binding]; other site 637380010142 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 637380010143 heterotetramer interface [polypeptide binding]; other site 637380010144 active site pocket [active] 637380010145 cleavage site 637380010146 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 637380010147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380010148 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 637380010149 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 637380010150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380010151 NAD(P) binding site [chemical binding]; other site 637380010152 active site 637380010153 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380010154 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 637380010155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380010156 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 637380010157 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 637380010158 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 637380010159 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 637380010160 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 637380010161 putative L-serine binding site [chemical binding]; other site 637380010162 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380010163 DNA polymerase IV; Validated; Region: PRK01810 637380010164 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 637380010165 active site 637380010166 DNA binding site [nucleotide binding] 637380010167 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 637380010168 peptidase T-like protein; Region: PepT-like; TIGR01883 637380010169 metal binding site [ion binding]; metal-binding site 637380010170 putative dimer interface [polypeptide binding]; other site 637380010171 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380010172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380010173 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 637380010174 Predicted membrane protein [Function unknown]; Region: COG4129 637380010175 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 637380010176 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 637380010177 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637380010178 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 637380010179 Walker A/P-loop; other site 637380010180 ATP binding site [chemical binding]; other site 637380010181 Q-loop/lid; other site 637380010182 ABC transporter signature motif; other site 637380010183 Walker B; other site 637380010184 D-loop; other site 637380010185 H-loop/switch region; other site 637380010186 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637380010187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380010188 dimer interface [polypeptide binding]; other site 637380010189 conserved gate region; other site 637380010190 putative PBP binding loops; other site 637380010191 ABC-ATPase subunit interface; other site 637380010192 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637380010193 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 637380010194 substrate binding pocket [chemical binding]; other site 637380010195 membrane-bound complex binding site; other site 637380010196 hinge residues; other site 637380010197 Protein of unknown function (DUF1094); Region: DUF1094; pfam06491 637380010198 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 637380010199 nudix motif; other site 637380010200 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 637380010201 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 637380010202 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 637380010203 E3 interaction surface; other site 637380010204 lipoyl attachment site [posttranslational modification]; other site 637380010205 e3 binding domain; Region: E3_binding; pfam02817 637380010206 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 637380010207 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 637380010208 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 637380010209 alpha subunit interface [polypeptide binding]; other site 637380010210 TPP binding site [chemical binding]; other site 637380010211 heterodimer interface [polypeptide binding]; other site 637380010212 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637380010213 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 637380010214 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 637380010215 tetramer interface [polypeptide binding]; other site 637380010216 TPP-binding site [chemical binding]; other site 637380010217 heterodimer interface [polypeptide binding]; other site 637380010218 phosphorylation loop region [posttranslational modification] 637380010219 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 637380010220 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380010221 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380010222 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 637380010223 Acetokinase family; Region: Acetate_kinase; cl01029 637380010224 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 637380010225 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 637380010226 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 637380010227 NAD binding site [chemical binding]; other site 637380010228 Phe binding site; other site 637380010229 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 637380010230 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 637380010231 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 637380010232 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637380010233 putative active site [active] 637380010234 heme pocket [chemical binding]; other site 637380010235 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 637380010236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380010237 Walker A motif; other site 637380010238 ATP binding site [chemical binding]; other site 637380010239 Walker B motif; other site 637380010240 arginine finger; other site 637380010241 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 637380010242 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 637380010243 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 637380010244 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 637380010245 active site 637380010246 catalytic site [active] 637380010247 metal binding site [ion binding]; metal-binding site 637380010248 dimer interface [polypeptide binding]; other site 637380010249 conserved hypothetical integral membrane protein; Region: TIGR03766 637380010250 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 637380010251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380010252 active site 637380010253 phosphorylation site [posttranslational modification] 637380010254 intermolecular recognition site; other site 637380010255 dimerization interface [polypeptide binding]; other site 637380010256 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 637380010257 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 637380010258 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 637380010259 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 637380010260 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 637380010261 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 637380010262 Walker A/P-loop; other site 637380010263 ATP binding site [chemical binding]; other site 637380010264 Q-loop/lid; other site 637380010265 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 637380010266 ABC transporter signature motif; other site 637380010267 Walker B; other site 637380010268 D-loop; other site 637380010269 H-loop/switch region; other site 637380010270 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 637380010271 arginine repressor; Provisional; Region: PRK04280 637380010272 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 637380010273 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 637380010274 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 637380010275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380010276 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 637380010277 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 637380010278 TPP-binding site; other site 637380010279 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637380010280 PYR/PP interface [polypeptide binding]; other site 637380010281 dimer interface [polypeptide binding]; other site 637380010282 TPP binding site [chemical binding]; other site 637380010283 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637380010284 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 637380010285 substrate binding pocket [chemical binding]; other site 637380010286 chain length determination region; other site 637380010287 substrate-Mg2+ binding site; other site 637380010288 catalytic residues [active] 637380010289 aspartate-rich region 1; other site 637380010290 active site lid residues [active] 637380010291 aspartate-rich region 2; other site 637380010292 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 637380010293 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 637380010294 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 637380010295 generic binding surface II; other site 637380010296 generic binding surface I; other site 637380010297 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 637380010298 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 637380010299 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 637380010300 homodimer interface [polypeptide binding]; other site 637380010301 NADP binding site [chemical binding]; other site 637380010302 substrate binding site [chemical binding]; other site 637380010303 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 637380010304 putative RNA binding site [nucleotide binding]; other site 637380010305 Protein of unknown function (DUF322); Region: DUF322; cl00574 637380010306 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 637380010307 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 637380010308 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 637380010309 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 637380010310 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 637380010311 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 637380010312 carboxyltransferase (CT) interaction site; other site 637380010313 biotinylation site [posttranslational modification]; other site 637380010314 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 637380010315 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 637380010316 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; cl09803 637380010317 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 637380010318 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 637380010319 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 637380010320 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 637380010321 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 637380010322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380010323 Walker A motif; other site 637380010324 ATP binding site [chemical binding]; other site 637380010325 Walker B motif; other site 637380010326 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 637380010327 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380010328 elongation factor P; Validated; Region: PRK00529 637380010329 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 637380010330 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 637380010331 RNA binding site [nucleotide binding]; other site 637380010332 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 637380010333 RNA binding site [nucleotide binding]; other site 637380010334 aminopeptidase; Provisional; Region: PRK09795 637380010335 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 637380010336 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 637380010337 active site 637380010338 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 637380010339 trimer interface [polypeptide binding]; other site 637380010340 active site 637380010341 dimer interface [polypeptide binding]; other site 637380010342 Conserved membrane protein YqhR; Region: YqhR; pfam11085 637380010343 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 637380010344 CCC1-related family of proteins; Region: CCC1_like; cl00278 637380010345 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 637380010346 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637380010347 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637380010348 motif II; other site 637380010349 manganese transport transcriptional regulator; Provisional; Region: PRK03902 637380010350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380010351 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 637380010352 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 637380010353 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 637380010354 FeS/SAM binding site; other site 637380010355 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380010356 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 637380010357 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 637380010358 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 637380010359 active site residue [active] 637380010360 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637380010361 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637380010362 DNA binding site [nucleotide binding] 637380010363 domain linker motif; other site 637380010364 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 637380010365 putative dimerization interface [polypeptide binding]; other site 637380010366 putative ligand binding site [chemical binding]; other site 637380010367 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380010368 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380010369 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 637380010370 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 637380010371 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637380010372 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 637380010373 Walker A/P-loop; other site 637380010374 ATP binding site [chemical binding]; other site 637380010375 Q-loop/lid; other site 637380010376 ABC transporter signature motif; other site 637380010377 Walker B; other site 637380010378 D-loop; other site 637380010379 H-loop/switch region; other site 637380010380 Predicted transcriptional regulators [Transcription]; Region: COG1725 637380010381 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637380010382 DNA-binding site [nucleotide binding]; DNA binding site 637380010383 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 637380010384 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 637380010385 tetramer interface [polypeptide binding]; other site 637380010386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380010387 catalytic residue [active] 637380010388 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 637380010389 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 637380010390 tetramer interface [polypeptide binding]; other site 637380010391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380010392 catalytic residue [active] 637380010393 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 637380010394 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 637380010395 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 637380010396 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 637380010397 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637380010398 ATP binding site [chemical binding]; other site 637380010399 putative Mg++ binding site [ion binding]; other site 637380010400 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637380010401 nucleotide binding region [chemical binding]; other site 637380010402 ATP-binding site [chemical binding]; other site 637380010403 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 637380010404 shikimate kinase; Reviewed; Region: aroK; PRK00131 637380010405 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 637380010406 ADP binding site [chemical binding]; other site 637380010407 magnesium binding site [ion binding]; other site 637380010408 putative shikimate binding site; other site 637380010409 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 637380010410 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 637380010411 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 637380010412 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 637380010413 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 637380010414 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 637380010415 Type II/IV secretion system protein; Region: GSPII_E; pfam00437 637380010416 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380010417 Walker A motif; other site 637380010418 ATP binding site [chemical binding]; other site 637380010419 Walker B motif; other site 637380010420 Predicted transcriptional regulator [Transcription]; Region: COG2345 637380010421 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380010422 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 637380010423 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 637380010424 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 637380010425 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 637380010426 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 637380010427 active site 637380010428 homodimer interface [polypeptide binding]; other site 637380010429 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 637380010430 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 637380010431 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 637380010432 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 637380010433 Pterin binding enzyme; Region: Pterin_bind; pfam00809 637380010434 substrate binding pocket [chemical binding]; other site 637380010435 dimer interface [polypeptide binding]; other site 637380010436 inhibitor binding site; inhibition site 637380010437 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 637380010438 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 637380010439 B12 binding site [chemical binding]; other site 637380010440 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 637380010441 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 637380010442 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 637380010443 FAD binding site [chemical binding]; other site 637380010444 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637380010445 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637380010446 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637380010447 catalytic residue [active] 637380010448 cystathionine beta-lyase; Provisional; Region: PRK08064 637380010449 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 637380010450 homodimer interface [polypeptide binding]; other site 637380010451 substrate-cofactor binding pocket; other site 637380010452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380010453 catalytic residue [active] 637380010454 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 637380010455 catalytic triad [active] 637380010456 conserved cis-peptide bond; other site 637380010457 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637380010458 dimerization interface [polypeptide binding]; other site 637380010459 putative DNA binding site [nucleotide binding]; other site 637380010460 putative Zn2+ binding site [ion binding]; other site 637380010461 Uncharacterized conserved protein [Function unknown]; Region: COG1565 637380010462 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636 637380010463 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380010464 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 637380010465 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 637380010466 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 637380010467 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 637380010468 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 637380010469 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 637380010470 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2)...; Region: phosphohexomutase; cl03757 637380010471 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 637380010472 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 637380010473 active site 637380010474 Substrate binding site [chemical binding]; other site 637380010475 Mg++ binding site [ion binding]; other site 637380010476 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 637380010477 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2)...; Region: phosphohexomutase; cl03757 637380010478 metal binding site [ion binding]; metal-binding site 637380010479 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 637380010480 PhoU domain; Region: PhoU; pfam01895 637380010481 PhoU domain; Region: PhoU; pfam01895 637380010482 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 637380010483 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 637380010484 Walker A/P-loop; other site 637380010485 ATP binding site [chemical binding]; other site 637380010486 Q-loop/lid; other site 637380010487 ABC transporter signature motif; other site 637380010488 Walker B; other site 637380010489 D-loop; other site 637380010490 H-loop/switch region; other site 637380010491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380010492 dimer interface [polypeptide binding]; other site 637380010493 conserved gate region; other site 637380010494 putative PBP binding loops; other site 637380010495 ABC-ATPase subunit interface; other site 637380010496 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 637380010497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380010498 dimer interface [polypeptide binding]; other site 637380010499 conserved gate region; other site 637380010500 putative PBP binding loops; other site 637380010501 ABC-ATPase subunit interface; other site 637380010502 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380010503 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 637380010504 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637380010505 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 637380010506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380010507 putative substrate translocation pore; other site 637380010508 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 637380010509 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 637380010510 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 637380010511 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 637380010512 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 637380010513 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 637380010514 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 637380010515 metal binding site 2 [ion binding]; metal-binding site 637380010516 putative DNA binding helix; other site 637380010517 metal binding site 1 [ion binding]; metal-binding site 637380010518 dimer interface [polypeptide binding]; other site 637380010519 structural Zn2+ binding site [ion binding]; other site 637380010520 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 637380010521 ABC-ATPase subunit interface; other site 637380010522 dimer interface [polypeptide binding]; other site 637380010523 putative PBP binding regions; other site 637380010524 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 637380010525 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 637380010526 Uncharacterized conserved protein [Function unknown]; Region: COG1284 637380010527 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 637380010528 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 637380010529 endonuclease IV; Provisional; Region: PRK01060 637380010530 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019 637380010531 AP (apurinic/apyrimidinic) site pocket; other site 637380010532 DNA interaction; other site 637380010533 Metal-binding active site; metal-binding site 637380010534 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 637380010535 DEAD-like helicases superfamily; Region: DEXDc; smart00487 637380010536 ATP binding site [chemical binding]; other site 637380010537 Mg++ binding site [ion binding]; other site 637380010538 motif III; other site 637380010539 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637380010540 nucleotide binding region [chemical binding]; other site 637380010541 ATP-binding site [chemical binding]; other site 637380010542 LytB protein; Region: LYTB; cl00507 637380010543 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 637380010544 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 637380010545 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 637380010546 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 637380010547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380010548 Cytochrome c; Region: Cytochrom_C; cl11414 637380010549 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 637380010550 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 637380010551 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 637380010552 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637380010553 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 637380010554 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 637380010555 DNA binding residues [nucleotide binding] 637380010556 DNA primase; Validated; Region: dnaG; PRK05667 637380010557 CHC2 zinc finger; Region: zf-CHC2; cl02597 637380010558 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 637380010559 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 637380010560 active site 637380010561 metal binding site [ion binding]; metal-binding site 637380010562 interdomain interaction site; other site 637380010563 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 637380010564 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 637380010565 Domain of unknown function (DUF299); Region: DUF299; cl00780 637380010566 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380010567 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_4; cd04617 637380010568 FOG: CBS domain [General function prediction only]; Region: COG0517 637380010569 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 637380010570 Recombination protein O N terminal; Region: RecO_N; pfam11967 637380010571 Recombination protein O C terminal; Region: RecO_C; pfam02565 637380010572 GTPase Era; Reviewed; Region: era; PRK00089 637380010573 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 637380010574 G1 box; other site 637380010575 GTP/Mg2+ binding site [chemical binding]; other site 637380010576 Switch I region; other site 637380010577 G2 box; other site 637380010578 Switch II region; other site 637380010579 G3 box; other site 637380010580 G4 box; other site 637380010581 G5 box; other site 637380010582 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 637380010583 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 637380010584 active site 637380010585 catalytic motif [active] 637380010586 Zn binding site [ion binding]; other site 637380010587 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 637380010588 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 637380010589 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 637380010590 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 637380010591 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637380010592 Zn2+ binding site [ion binding]; other site 637380010593 Mg2+ binding site [ion binding]; other site 637380010594 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 637380010595 PhoH-like protein; Region: PhoH; cl12134 637380010596 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 637380010597 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 637380010598 YabP family; Region: YabP; cl06766 637380010599 GatB domain; Region: GatB_Yqey; cl11497 637380010600 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 637380010601 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 637380010602 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 637380010603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 637380010604 FeS/SAM binding site; other site 637380010605 TRAM domain; Region: TRAM; cl01282 637380010606 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 637380010607 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 637380010608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380010609 S-adenosylmethionine binding site [chemical binding]; other site 637380010610 chaperone protein DnaJ; Provisional; Region: PRK14280 637380010611 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 637380010612 HSP70 interaction site [polypeptide binding]; other site 637380010613 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 637380010614 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 637380010615 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 637380010616 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 637380010617 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 637380010618 dimer interface [polypeptide binding]; other site 637380010619 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 637380010620 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 637380010621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380010622 HrcA protein C terminal domain; Region: HrcA; pfam01628 637380010623 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 637380010624 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 637380010625 FeS/SAM binding site; other site 637380010626 HemN C-terminal region; Region: HemN_C; pfam06969 637380010627 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380010628 GTP-binding protein LepA; Provisional; Region: PRK05433 637380010629 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 637380010630 G1 box; other site 637380010631 putative GEF interaction site [polypeptide binding]; other site 637380010632 GTP/Mg2+ binding site [chemical binding]; other site 637380010633 Switch I region; other site 637380010634 G2 box; other site 637380010635 G3 box; other site 637380010636 Switch II region; other site 637380010637 G4 box; other site 637380010638 G5 box; other site 637380010639 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 637380010640 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 637380010641 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 637380010642 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 637380010643 Germination protease; Region: Peptidase_A25; cl04057 637380010644 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 637380010645 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 637380010646 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 637380010647 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 637380010648 Competence protein; Region: Competence; cl00471 637380010649 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380010650 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 637380010651 catalytic motif [active] 637380010652 Zn binding site [ion binding]; other site 637380010653 SLBB domain; Region: SLBB; pfam10531 637380010654 comEA protein; Region: comE; TIGR01259 637380010655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380010656 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 637380010657 ubiquinone biosynthesis O-methyltransferase; Region: UbiG; TIGR01983 637380010658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380010659 S-adenosylmethionine binding site [chemical binding]; other site 637380010660 Domain of unknown function DUF143; Region: DUF143; cl00519 637380010661 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 637380010662 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 637380010663 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 637380010664 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 637380010665 active site 637380010666 (T/H)XGH motif; other site 637380010667 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 637380010668 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 637380010669 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 637380010670 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 637380010671 shikimate binding site; other site 637380010672 NAD(P) binding site [chemical binding]; other site 637380010673 GTPase YqeH; Provisional; Region: PRK13796 637380010674 YqeH. YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically...; Region: YqeH; cd01855 637380010675 GTP/Mg2+ binding site [chemical binding]; other site 637380010676 G4 box; other site 637380010677 G5 box; other site 637380010678 G1 box; other site 637380010679 Switch I region; other site 637380010680 G2 box; other site 637380010681 G3 box; other site 637380010682 Switch II region; other site 637380010683 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637380010684 active site 637380010685 motif I; other site 637380010686 motif II; other site 637380010687 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 637380010688 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637380010689 aconitate hydratase; Validated; Region: PRK09277 637380010690 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 637380010691 DNA binding residues [nucleotide binding] 637380010692 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 637380010693 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380010694 Walker A/P-loop; other site 637380010695 ATP binding site [chemical binding]; other site 637380010696 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380010697 ABC transporter signature motif; other site 637380010698 Walker B; other site 637380010699 D-loop; other site 637380010700 H-loop/switch region; other site 637380010701 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 637380010702 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 637380010703 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637380010704 ATP binding site [chemical binding]; other site 637380010705 putative Mg++ binding site [ion binding]; other site 637380010706 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 637380010707 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 637380010708 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 637380010709 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 637380010710 HsdM N-terminal domain; Region: HsdM_N; pfam12161 637380010711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380010712 LAGLIDADG endonuclease; Region: LAGLIDADG_1; pfam00961 637380010713 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380010714 non-specific DNA binding site [nucleotide binding]; other site 637380010715 salt bridge; other site 637380010716 sequence-specific DNA binding site [nucleotide binding]; other site 637380010717 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 637380010718 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 637380010719 catalytic residues [active] 637380010720 catalytic nucleophile [active] 637380010721 Recombinase; Region: Recombinase; pfam07508 637380010722 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380010723 non-specific DNA binding site [nucleotide binding]; other site 637380010724 salt bridge; other site 637380010725 sequence-specific DNA binding site [nucleotide binding]; other site 637380010726 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 637380010727 catalytic residues [active] 637380010728 catalytic nucleophile [active] 637380010729 Recombinase; Region: Recombinase; pfam07508 637380010730 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 637380010731 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 637380010732 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 637380010733 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 637380010734 dimer interface [polypeptide binding]; other site 637380010735 FMN binding site [chemical binding]; other site 637380010736 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 637380010737 synthetase active site [active] 637380010738 NTP binding site [chemical binding]; other site 637380010739 metal binding site [ion binding]; metal-binding site 637380010740 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cd00016 637380010741 dimer interface [polypeptide binding]; other site 637380010742 Alkaline phosphatase homologues; Region: alkPPc; smart00098 637380010743 active site 637380010744 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380010745 Coenzyme A binding pocket [chemical binding]; other site 637380010746 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380010747 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380010748 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637380010749 CHAT domain; Region: CHAT; cl02083 637380010750 potential frameshift: common BLAST hit: gi|227817131|ref|YP_002817140.1| putative phosphoglycerate mutase family 637380010751 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 637380010752 catalytic core [active] 637380010753 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 637380010754 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 637380010755 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 637380010756 putative active site [active] 637380010757 catalytic triad [active] 637380010758 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 637380010759 putative integrin binding motif; other site 637380010760 PA/protease domain interface [polypeptide binding]; other site 637380010761 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 637380010762 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 637380010763 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 637380010764 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 637380010765 cofactor binding site; other site 637380010766 metal binding site [ion binding]; metal-binding site 637380010767 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 637380010768 aromatic arch; other site 637380010769 DCoH dimer interaction site [polypeptide binding]; other site 637380010770 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 637380010771 DCoH tetramer interaction site [polypeptide binding]; other site 637380010772 substrate binding site [chemical binding]; other site 637380010773 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 637380010774 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 637380010775 putative metal binding site [ion binding]; other site 637380010776 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 637380010777 active site 637380010778 metal binding site [ion binding]; metal-binding site 637380010779 DoxX; Region: DoxX; cl00976 637380010780 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 637380010781 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380010782 non-specific DNA binding site [nucleotide binding]; other site 637380010783 salt bridge; other site 637380010784 sequence-specific DNA binding site [nucleotide binding]; other site 637380010785 Cupin domain; Region: Cupin_2; cl09118 637380010786 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of...; Region: R_hydratase; cd03449 637380010787 dimer interaction site [polypeptide binding]; other site 637380010788 substrate-binding tunnel; other site 637380010789 active site 637380010790 catalytic site [active] 637380010791 substrate binding site [chemical binding]; other site 637380010792 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380010793 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380010794 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380010795 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 637380010796 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 637380010797 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 637380010798 Walker A/P-loop; other site 637380010799 ATP binding site [chemical binding]; other site 637380010800 Q-loop/lid; other site 637380010801 ABC transporter signature motif; other site 637380010802 Walker B; other site 637380010803 D-loop; other site 637380010804 H-loop/switch region; other site 637380010805 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 637380010806 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 637380010807 ABC-ATPase subunit interface; other site 637380010808 dimer interface [polypeptide binding]; other site 637380010809 putative PBP binding regions; other site 637380010810 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 637380010811 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 637380010812 intersubunit interface [polypeptide binding]; other site 637380010813 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 637380010814 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 637380010815 putative catalytic cysteine [active] 637380010816 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 637380010817 putative active site [active] 637380010818 metal binding site [ion binding]; metal-binding site 637380010819 cystathionine beta-lyase; Provisional; Region: PRK07671 637380010820 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 637380010821 homodimer interface [polypeptide binding]; other site 637380010822 substrate-cofactor binding pocket; other site 637380010823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380010824 catalytic residue [active] 637380010825 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 637380010826 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 637380010827 dimer interface [polypeptide binding]; other site 637380010828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380010829 catalytic residue [active] 637380010830 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 637380010831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380010832 S-adenosylmethionine binding site [chemical binding]; other site 637380010833 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 637380010834 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 637380010835 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 637380010836 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637380010837 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 637380010838 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 637380010839 domain; Region: GreA_GreB_N; pfam03449 637380010840 C-term; Region: GreA_GreB; pfam01272 637380010841 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage...; Region: UMPK; cd02023 637380010842 ATP-binding site [chemical binding]; other site 637380010843 Sugar specificity; other site 637380010844 Pyrimidine base specificity; other site 637380010845 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 637380010846 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 637380010847 Peptidase family U32; Region: Peptidase_U32; cl03113 637380010848 Protein of unknown function (DUF556); Region: DUF556; cl00822 637380010849 Peptidase family U32; Region: Peptidase_U32; cl03113 637380010850 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 637380010851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380010852 S-adenosylmethionine binding site [chemical binding]; other site 637380010853 YceG-like family; Region: YceG; pfam02618 637380010854 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 637380010855 dimerization interface [polypeptide binding]; other site 637380010856 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 637380010857 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 637380010858 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 637380010859 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 637380010860 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 637380010861 motif 1; other site 637380010862 active site 637380010863 motif 2; other site 637380010864 motif 3; other site 637380010865 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 637380010866 DHHA1 domain; Region: DHHA1; pfam02272 637380010867 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 637380010868 Domain of unknown function DUF20; Region: UPF0118; cl00465 637380010869 RecD/TraA family; Region: recD_rel; TIGR01448 637380010870 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637380010871 binding surface 637380010872 TPR motif; other site 637380010873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637380010874 binding surface 637380010875 TPR motif; other site 637380010876 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 637380010877 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 637380010878 Ligand Binding Site [chemical binding]; other site 637380010879 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637380010880 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 637380010881 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637380010882 catalytic residue [active] 637380010883 Predicted transcriptional regulator [Transcription]; Region: COG1959 637380010884 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380010885 recombination factor protein RarA; Reviewed; Region: PRK13342 637380010886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380010887 Walker A motif; other site 637380010888 ATP binding site [chemical binding]; other site 637380010889 Walker B motif; other site 637380010890 arginine finger; other site 637380010891 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440 637380010892 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 637380010893 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 637380010894 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 637380010895 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-...; Region: YgdL_like; cd00755 637380010896 putative ATP binding site [chemical binding]; other site 637380010897 putative substrate interface [chemical binding]; other site 637380010898 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 637380010899 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 637380010900 dimer interface [polypeptide binding]; other site 637380010901 anticodon binding site; other site 637380010902 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 637380010903 homodimer interface [polypeptide binding]; other site 637380010904 motif 1; other site 637380010905 active site 637380010906 motif 2; other site 637380010907 GAD domain; Region: GAD; pfam02938 637380010908 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 637380010909 motif 3; other site 637380010910 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 637380010911 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 637380010912 dimer interface [polypeptide binding]; other site 637380010913 motif 1; other site 637380010914 active site 637380010915 motif 2; other site 637380010916 motif 3; other site 637380010917 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 637380010918 anticodon binding site; other site 637380010919 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 637380010920 putative active site [active] 637380010921 dimerization interface [polypeptide binding]; other site 637380010922 putative tRNAtyr binding site [nucleotide binding]; other site 637380010923 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 637380010924 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 637380010925 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 637380010926 synthetase active site [active] 637380010927 NTP binding site [chemical binding]; other site 637380010928 metal binding site [ion binding]; metal-binding site 637380010929 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 637380010930 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 637380010931 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 637380010932 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 637380010933 DHH family; Region: DHH; pfam01368 637380010934 DHHA1 domain; Region: DHHA1; pfam02272 637380010935 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 637380010936 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 637380010937 Cation efflux family; Region: Cation_efflux; cl00316 637380010938 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 637380010939 Protein export membrane protein; Region: SecD_SecF; cl14618 637380010940 Protein export membrane protein; Region: SecD_SecF; cl14618 637380010941 stage V sporulation protein B; Region: spore_V_B; TIGR02900 637380010942 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 637380010943 MatE; Region: MatE; pfam01554 637380010944 Protein of unknown function (DUF421); Region: DUF421; cl00990 637380010945 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 637380010946 Preprotein translocase subunit; Region: YajC; cl00806 637380010947 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 637380010948 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 637380010949 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 637380010950 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 637380010951 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 637380010952 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380010953 Walker A motif; other site 637380010954 ATP binding site [chemical binding]; other site 637380010955 Walker B motif; other site 637380010956 arginine finger; other site 637380010957 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 637380010958 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 637380010959 RuvA N terminal domain; Region: RuvA_N; pfam01330 637380010960 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 637380010961 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 637380010962 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: FeuA; cd01138 637380010963 putative ligand binding residues [chemical binding]; other site 637380010964 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 637380010965 BofC C-terminal domain; Region: BofC_C; pfam08955 637380010966 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 637380010967 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 637380010968 putative peptidoglycan binding site; other site 637380010969 Quinolinate synthetase A protein; Region: NadA; cl00420 637380010970 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 637380010971 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 637380010972 dimerization interface [polypeptide binding]; other site 637380010973 active site 637380010974 L-aspartate oxidase; Provisional; Region: PRK08071 637380010975 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380010976 domain; Region: Succ_DH_flav_C; pfam02910 637380010977 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637380010978 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637380010979 catalytic residue [active] 637380010980 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 637380010981 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380010982 3H domain; Region: 3H; pfam02829 637380010983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 637380010984 MOSC domain; Region: MOSC; pfam03473 637380010985 3-alpha domain; Region: 3-alpha; pfam03475 637380010986 prephenate dehydratase; Provisional; Region: PRK11898 637380010987 Prephenate dehydratase; Region: PDT; pfam00800 637380010988 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 637380010989 putative L-Phe binding site [chemical binding]; other site 637380010990 FtsX-like permease family; Region: FtsX; pfam02687 637380010991 FtsX-like permease family; Region: FtsX; pfam02687 637380010992 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637380010993 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637380010994 Walker A/P-loop; other site 637380010995 ATP binding site [chemical binding]; other site 637380010996 Q-loop/lid; other site 637380010997 ABC transporter signature motif; other site 637380010998 Walker B; other site 637380010999 D-loop; other site 637380011000 H-loop/switch region; other site 637380011001 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637380011002 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380011003 ATP binding site [chemical binding]; other site 637380011004 Mg2+ binding site [ion binding]; other site 637380011005 G-X-G motif; other site 637380011006 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380011007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380011008 active site 637380011009 phosphorylation site [posttranslational modification] 637380011010 intermolecular recognition site; other site 637380011011 dimerization interface [polypeptide binding]; other site 637380011012 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380011013 DNA binding site [nucleotide binding] 637380011014 GTPase CgtA; Reviewed; Region: obgE; PRK12297 637380011015 GTP1/OBG; Region: GTP1_OBG; pfam01018 637380011016 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 637380011017 G1 box; other site 637380011018 GTP/Mg2+ binding site [chemical binding]; other site 637380011019 Switch I region; other site 637380011020 G2 box; other site 637380011021 G3 box; other site 637380011022 Switch II region; other site 637380011023 G4 box; other site 637380011024 G5 box; other site 637380011025 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 637380011026 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 637380011027 Protein of unknown function (DUF464); Region: DUF464; cl01080 637380011028 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 637380011029 BACI_c44320; ribosomal protein L21 leader, RF00559 637380011030 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 637380011031 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 637380011032 homodimer interface [polypeptide binding]; other site 637380011033 oligonucleotide binding site [chemical binding]; other site 637380011034 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 637380011035 active site 637380011036 putative substrate binding region [chemical binding]; other site 637380011037 Peptidase family M23; Region: Peptidase_M23; pfam01551 637380011038 septum site-determining protein MinD; Region: minD_bact; TIGR01968 637380011039 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036 637380011040 Switch I; other site 637380011041 Switch II; other site 637380011042 septum formation inhibitor; Reviewed; Region: minC; PRK00513 637380011043 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 637380011044 rod shape-determining protein MreD; Region: MreD; cl01087 637380011045 rod shape-determining protein MreC; Provisional; Region: PRK13922 637380011046 rod shape-determining protein MreC; Region: MreC; pfam04085 637380011047 rod shape-determining protein MreB; Provisional; Region: PRK13927 637380011048 Cell division protein FtsA; Region: FtsA; cl11496 637380011049 hypothetical protein; Reviewed; Region: PRK00024 637380011050 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 637380011051 MPN+ (JAMM) motif; other site 637380011052 Zinc-binding site [ion binding]; other site 637380011053 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 637380011054 active site 637380011055 dimer interface [polypeptide binding]; other site 637380011056 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 637380011057 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637380011058 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637380011059 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 637380011060 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 637380011061 active site 637380011062 HIGH motif; other site 637380011063 nucleotide binding site [chemical binding]; other site 637380011064 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 637380011065 active site 637380011066 KMSKS motif; other site 637380011067 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 637380011068 tRNA binding surface [nucleotide binding]; other site 637380011069 anticodon binding site; other site 637380011070 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 637380011071 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637380011072 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 637380011073 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 637380011074 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 637380011075 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 637380011076 inhibitor-cofactor binding pocket; inhibition site 637380011077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380011078 catalytic residue [active] 637380011079 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 637380011080 dimer interface [polypeptide binding]; other site 637380011081 active site 637380011082 Schiff base residues; other site 637380011083 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 637380011084 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 637380011085 active site 637380011086 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 637380011087 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 637380011088 domain interfaces; other site 637380011089 active site 637380011090 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 637380011091 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 637380011092 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 637380011093 tRNA; other site 637380011094 putative tRNA binding site [nucleotide binding]; other site 637380011095 putative NADP binding site [chemical binding]; other site 637380011096 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 637380011097 Transcriptional regulators [Transcription]; Region: MarR; COG1846 637380011098 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380011099 OsmC-like protein; Region: OsmC; cl00767 637380011100 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 637380011101 G1 box; other site 637380011102 GTP/Mg2+ binding site [chemical binding]; other site 637380011103 Switch I region; other site 637380011104 G2 box; other site 637380011105 G3 box; other site 637380011106 Switch II region; other site 637380011107 G4 box; other site 637380011108 G5 box; other site 637380011109 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 637380011110 Found in ATP-dependent protease La (LON); Region: LON; cl01056 637380011111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380011112 Walker A motif; other site 637380011113 ATP binding site [chemical binding]; other site 637380011114 Walker B motif; other site 637380011115 arginine finger; other site 637380011116 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 637380011117 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 637380011118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380011119 Walker A motif; other site 637380011120 ATP binding site [chemical binding]; other site 637380011121 Walker B motif; other site 637380011122 arginine finger; other site 637380011123 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 637380011124 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 637380011125 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 637380011126 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380011127 Walker A motif; other site 637380011128 ATP binding site [chemical binding]; other site 637380011129 Walker B motif; other site 637380011130 arginine finger; other site 637380011131 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 637380011132 trigger factor; Provisional; Region: tig; PRK01490 637380011133 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 637380011134 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 637380011135 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 637380011136 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 637380011137 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 637380011138 active site 637380011139 metal binding site [ion binding]; metal-binding site 637380011140 homotetramer interface [polypeptide binding]; other site 637380011141 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 637380011142 active site 637380011143 dimerization interface [polypeptide binding]; other site 637380011144 ribonuclease PH; Reviewed; Region: rph; PRK00173 637380011145 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 637380011146 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 637380011147 Sporulation and spore germination; Region: Germane; pfam10646 637380011148 Spore germination protein [General function prediction only]; Region: COG5401 637380011149 Sporulation and spore germination; Region: Germane; pfam10646 637380011150 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 637380011151 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 637380011152 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 637380011153 potential catalytic triad [active] 637380011154 conserved cys residue [active] 637380011155 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380011156 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380011157 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 637380011158 potential catalytic triad [active] 637380011159 conserved cys residue [active] 637380011160 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 637380011161 DNA binding residues [nucleotide binding] 637380011162 dimerization interface [polypeptide binding]; other site 637380011163 Sulfate transporter family; Region: Sulfate_transp; cl00967 637380011164 Permease family; Region: Xan_ur_permease; pfam00860 637380011165 EamA-like transporter family; Region: EamA; cl01037 637380011166 EamA-like transporter family; Region: EamA; cl01037 637380011167 cytosine deaminase; Provisional; Region: PRK05985 637380011168 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and...; Region: Bact_CD; cd01293 637380011169 active site 637380011170 cytosine deaminase; Provisional; Region: PRK05985 637380011171 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and...; Region: Bact_CD; cd01293 637380011172 active site 637380011173 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 637380011174 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 637380011175 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 637380011176 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 637380011177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380011178 dimer interface [polypeptide binding]; other site 637380011179 conserved gate region; other site 637380011180 ABC-ATPase subunit interface; other site 637380011181 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 637380011182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380011183 dimer interface [polypeptide binding]; other site 637380011184 conserved gate region; other site 637380011185 putative PBP binding loops; other site 637380011186 ABC-ATPase subunit interface; other site 637380011187 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 637380011188 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 637380011189 Walker A/P-loop; other site 637380011190 ATP binding site [chemical binding]; other site 637380011191 Q-loop/lid; other site 637380011192 ABC transporter signature motif; other site 637380011193 Walker B; other site 637380011194 D-loop; other site 637380011195 H-loop/switch region; other site 637380011196 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 637380011197 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 637380011198 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 637380011199 Walker A/P-loop; other site 637380011200 ATP binding site [chemical binding]; other site 637380011201 Q-loop/lid; other site 637380011202 ABC transporter signature motif; other site 637380011203 Walker B; other site 637380011204 D-loop; other site 637380011205 H-loop/switch region; other site 637380011206 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 637380011207 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 637380011208 Histidine kinase; Region: His_kinase; pfam06580 637380011209 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 637380011210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380011211 active site 637380011212 phosphorylation site [posttranslational modification] 637380011213 intermolecular recognition site; other site 637380011214 dimerization interface [polypeptide binding]; other site 637380011215 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637380011216 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637380011217 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637380011218 PspC domain; Region: PspC; cl00864 637380011219 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 637380011220 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380011221 non-specific DNA binding site [nucleotide binding]; other site 637380011222 salt bridge; other site 637380011223 sequence-specific DNA binding site [nucleotide binding]; other site 637380011224 Cupin domain; Region: Cupin_2; cl09118 637380011225 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cl00200 637380011226 amphipathic channel; other site 637380011227 Asn-Pro-Ala signature motifs; other site 637380011228 Predicted transcriptional regulator [Transcription]; Region: COG1959 637380011229 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380011230 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 637380011231 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 637380011232 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380011233 Walker A/P-loop; other site 637380011234 ATP binding site [chemical binding]; other site 637380011235 Q-loop/lid; other site 637380011236 ABC transporter signature motif; other site 637380011237 Walker B; other site 637380011238 D-loop; other site 637380011239 H-loop/switch region; other site 637380011240 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637380011241 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 637380011242 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 637380011243 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 637380011244 ligand binding site [chemical binding]; other site 637380011245 flagellar motor protein MotA; Validated; Region: PRK08124 637380011246 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 637380011247 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 637380011248 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 637380011249 active site 637380011250 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 637380011251 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 637380011252 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 637380011253 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380011254 domain; Region: Succ_DH_flav_C; pfam02910 637380011255 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 637380011256 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus...; Region: SQR_TypeB_1_TM; cd03497 637380011257 putative Iron-sulfur protein interface [polypeptide binding]; other site 637380011258 proximal heme binding site [chemical binding]; other site 637380011259 distal heme binding site [chemical binding]; other site 637380011260 putative dimer interface [polypeptide binding]; other site 637380011261 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 637380011262 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 637380011263 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 637380011264 UvrB/uvrC motif; Region: UVR; pfam02151 637380011265 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 637380011266 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 637380011267 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 637380011268 catalytic residues [active] 637380011269 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 637380011270 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 637380011271 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 637380011272 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 637380011273 Ligand binding site [chemical binding]; other site 637380011274 enoyl-CoA hydratase; Provisional; Region: PRK07658 637380011275 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 637380011276 substrate binding site [chemical binding]; other site 637380011277 oxyanion hole (OAH) forming residues; other site 637380011278 trimer interface [polypeptide binding]; other site 637380011279 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380011280 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 637380011281 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 637380011282 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 637380011283 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 637380011284 DinB superfamily; Region: DinB_2; cl00986 637380011285 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637380011286 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 637380011287 Walker A/P-loop; other site 637380011288 ATP binding site [chemical binding]; other site 637380011289 Q-loop/lid; other site 637380011290 ABC transporter signature motif; other site 637380011291 Walker B; other site 637380011292 D-loop; other site 637380011293 H-loop/switch region; other site 637380011294 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380011295 dimer interface [polypeptide binding]; other site 637380011296 phosphorylation site [posttranslational modification] 637380011297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380011298 ATP binding site [chemical binding]; other site 637380011299 Mg2+ binding site [ion binding]; other site 637380011300 G-X-G motif; other site 637380011301 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380011302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380011303 active site 637380011304 phosphorylation site [posttranslational modification] 637380011305 intermolecular recognition site; other site 637380011306 dimerization interface [polypeptide binding]; other site 637380011307 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380011308 DNA binding site [nucleotide binding] 637380011309 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 637380011310 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 637380011311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380011312 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 637380011313 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 637380011314 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 637380011315 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 637380011316 active site 637380011317 catalytic site [active] 637380011318 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 637380011319 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 637380011320 Walker A/P-loop; other site 637380011321 ATP binding site [chemical binding]; other site 637380011322 Q-loop/lid; other site 637380011323 ABC transporter signature motif; other site 637380011324 Walker B; other site 637380011325 D-loop; other site 637380011326 H-loop/switch region; other site 637380011327 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 637380011328 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 637380011329 ABC-ATPase subunit interface; other site 637380011330 dimer interface [polypeptide binding]; other site 637380011331 putative PBP binding regions; other site 637380011332 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 637380011333 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 637380011334 intersubunit interface [polypeptide binding]; other site 637380011335 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 637380011336 heme-binding site [chemical binding]; other site 637380011337 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 637380011338 heme-binding site [chemical binding]; other site 637380011339 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 637380011340 heme-binding site [chemical binding]; other site 637380011341 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 637380011342 heme-binding site [chemical binding]; other site 637380011343 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 637380011344 heme-binding site [chemical binding]; other site 637380011345 heme uptake protein IsdC; Region: IsdC; TIGR03656 637380011346 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 637380011347 heme-binding site [chemical binding]; other site 637380011348 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 637380011349 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 637380011350 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 637380011351 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637380011352 RNA binding surface [nucleotide binding]; other site 637380011353 PseudoU_synth_RluF_like: Pseudouridine synthase, Escherichia coli RluF like. This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluF; cd02554 637380011354 probable active site [active] 637380011355 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 637380011356 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 637380011357 Walker A/P-loop; other site 637380011358 ATP binding site [chemical binding]; other site 637380011359 Q-loop/lid; other site 637380011360 ABC transporter signature motif; other site 637380011361 Walker B; other site 637380011362 D-loop; other site 637380011363 H-loop/switch region; other site 637380011364 Smr domain; Region: Smr; cl02619 637380011365 hypothetical protein; Provisional; Region: PRK08609 637380011366 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 637380011367 active site 637380011368 primer binding site [nucleotide binding]; other site 637380011369 NTP binding site [chemical binding]; other site 637380011370 metal binding triad [ion binding]; metal-binding site 637380011371 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 637380011372 Colicin V production protein; Region: Colicin_V; cl00567 637380011373 Cell division protein ZapA; Region: ZapA; cl01146 637380011374 ribonuclease HIII; Provisional; Region: PRK00996 637380011375 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 637380011376 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 637380011377 RNA/DNA hybrid binding site [nucleotide binding]; other site 637380011378 active site 637380011379 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 637380011380 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (...; Region: EcAsnRS_like_N; cd04318 637380011381 putative dimer interface [polypeptide binding]; other site 637380011382 putative anticodon binding site; other site 637380011383 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776 637380011384 homodimer interface [polypeptide binding]; other site 637380011385 motif 1; other site 637380011386 motif 2; other site 637380011387 active site 637380011388 motif 3; other site 637380011389 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 637380011390 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 637380011391 putative tRNA-binding site [nucleotide binding]; other site 637380011392 B3/4 domain; Region: B3_4; cl11458 637380011393 tRNA synthetase B5 domain; Region: B5; cl08394 637380011394 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 637380011395 dimer interface [polypeptide binding]; other site 637380011396 motif 1; other site 637380011397 motif 3; other site 637380011398 motif 2; other site 637380011399 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 637380011400 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 637380011401 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 637380011402 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 637380011403 dimer interface [polypeptide binding]; other site 637380011404 motif 1; other site 637380011405 active site 637380011406 motif 2; other site 637380011407 motif 3; other site 637380011408 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 637380011409 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 637380011410 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 637380011411 small acid-soluble spore protein SspI; Provisional; Region: PRK02955; cl07940 637380011412 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 637380011413 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 637380011414 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 637380011415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380011416 putative substrate translocation pore; other site 637380011417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380011418 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 637380011419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380011420 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380011421 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 637380011422 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 637380011423 oligomer interface [polypeptide binding]; other site 637380011424 active site 637380011425 metal binding site [ion binding]; metal-binding site 637380011426 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 637380011427 dUTPase; Region: dUTPase_2; pfam08761 637380011428 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 637380011429 23S rRNA binding site [nucleotide binding]; other site 637380011430 L21 binding site [polypeptide binding]; other site 637380011431 L13 binding site [polypeptide binding]; other site 637380011432 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 637380011433 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 637380011434 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 637380011435 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 637380011436 BACI_c45680; ribosomal protein L20 leader, RF00558 637380011437 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 637380011438 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 637380011439 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 637380011440 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 637380011441 active site 637380011442 dimer interface [polypeptide binding]; other site 637380011443 motif 1; other site 637380011444 motif 2; other site 637380011445 motif 3; other site 637380011446 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 637380011447 anticodon binding site; other site 637380011448 YtxC-like family; Region: YtxC; cl08500 637380011449 primosomal protein DnaI; Reviewed; Region: PRK08939 637380011450 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 637380011451 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380011452 Walker A motif; other site 637380011453 ATP binding site [chemical binding]; other site 637380011454 Walker B motif; other site 637380011455 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 637380011456 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 637380011457 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 637380011458 ATP cone domain; Region: ATP-cone; pfam03477 637380011459 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 637380011460 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 637380011461 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380011462 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 637380011463 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 637380011464 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 637380011465 CoA-binding site [chemical binding]; other site 637380011466 ATP-binding [chemical binding]; other site 637380011467 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 637380011468 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 637380011469 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 637380011470 DNA binding site [nucleotide binding] 637380011471 catalytic residue [active] 637380011472 H2TH interface [polypeptide binding]; other site 637380011473 putative catalytic residues [active] 637380011474 turnover-facilitating residue; other site 637380011475 intercalation triad [nucleotide binding]; other site 637380011476 8OG recognition residue [nucleotide binding]; other site 637380011477 putative reading head residues; other site 637380011478 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 637380011479 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 637380011480 DNA polymerase I; Provisional; Region: PRK05755 637380011481 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 637380011482 active site 637380011483 metal binding site 1 [ion binding]; metal-binding site 637380011484 putative 5' ssDNA interaction site; other site 637380011485 metal binding site 3; metal-binding site 637380011486 metal binding site 2 [ion binding]; metal-binding site 637380011487 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 637380011488 putative DNA binding site [nucleotide binding]; other site 637380011489 putative metal binding site [ion binding]; other site 637380011490 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 637380011491 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 637380011492 active site 637380011493 DNA binding site [nucleotide binding] 637380011494 catalytic site [active] 637380011495 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 637380011496 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 637380011497 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 637380011498 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380011499 dimer interface [polypeptide binding]; other site 637380011500 phosphorylation site [posttranslational modification] 637380011501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380011502 ATP binding site [chemical binding]; other site 637380011503 Mg2+ binding site [ion binding]; other site 637380011504 G-X-G motif; other site 637380011505 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380011506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380011507 active site 637380011508 phosphorylation site [posttranslational modification] 637380011509 intermolecular recognition site; other site 637380011510 dimerization interface [polypeptide binding]; other site 637380011511 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380011512 DNA binding site [nucleotide binding] 637380011513 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of...; Region: R_hydratase; cd03449 637380011514 dimer interaction site [polypeptide binding]; other site 637380011515 substrate-binding tunnel; other site 637380011516 active site 637380011517 catalytic site [active] 637380011518 substrate binding site [chemical binding]; other site 637380011519 malate dehydrogenase; Reviewed; Region: PRK06223 637380011520 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 637380011521 NAD(P) binding site [chemical binding]; other site 637380011522 dimer interface [polypeptide binding]; other site 637380011523 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637380011524 substrate binding site [chemical binding]; other site 637380011525 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 637380011526 isocitrate dehydrogenase; Validated; Region: PRK07362 637380011527 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes...; Region: BSuCS-II_like; cd06110 637380011528 dimer interface [polypeptide binding]; other site 637380011529 Citrate synthase; Region: Citrate_synt; pfam00285 637380011530 active site 637380011531 citrylCoA binding site [chemical binding]; other site 637380011532 oxalacetate/citrate binding site [chemical binding]; other site 637380011533 coenzyme A binding site [chemical binding]; other site 637380011534 catalytic triad [active] 637380011535 Protein of unknown function (DUF441); Region: DUF441; cl01041 637380011536 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 637380011537 Domain of unknown function DUF20; Region: UPF0118; cl00465 637380011538 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 637380011539 pyruvate kinase; Provisional; Region: PRK06354 637380011540 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 637380011541 domain interfaces; other site 637380011542 active site 637380011543 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 637380011544 6-phosphofructokinase; Provisional; Region: PRK03202 637380011545 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 637380011546 active site 637380011547 ADP/pyrophosphate binding site [chemical binding]; other site 637380011548 dimerization interface [polypeptide binding]; other site 637380011549 allosteric effector site; other site 637380011550 fructose-1,6-bisphosphate binding site; other site 637380011551 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 637380011552 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 637380011553 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 637380011554 Transcriptional regulators [Transcription]; Region: FadR; COG2186 637380011555 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637380011556 DNA-binding site [nucleotide binding]; DNA binding site 637380011557 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 637380011558 Malic enzyme, N-terminal domain; Region: malic; pfam00390 637380011559 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 637380011560 putative NAD(P) binding site [chemical binding]; other site 637380011561 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 637380011562 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 637380011563 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 637380011564 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 637380011565 generic binding surface II; other site 637380011566 generic binding surface I; other site 637380011567 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 637380011568 DHH family; Region: DHH; pfam01368 637380011569 DHHA1 domain; Region: DHHA1; pfam02272 637380011570 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 637380011571 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637380011572 DNA-binding site [nucleotide binding]; DNA binding site 637380011573 DRTGG domain; Region: DRTGG; cl12147 637380011574 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 637380011575 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 637380011576 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380011577 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 637380011578 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 637380011579 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 637380011580 active site 637380011581 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 637380011582 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 637380011583 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 637380011584 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 637380011585 Probable transposase; Region: OrfB_IS605; pfam01385 637380011586 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 637380011587 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 637380011588 DNA binding residues [nucleotide binding] 637380011589 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 637380011590 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637380011591 Coenzyme A binding pocket [chemical binding]; other site 637380011592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380011593 Cupin domain; Region: Cupin_2; cl09118 637380011594 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380011595 non-specific DNA binding site [nucleotide binding]; other site 637380011596 salt bridge; other site 637380011597 sequence-specific DNA binding site [nucleotide binding]; other site 637380011598 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 637380011599 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 637380011600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380011601 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 637380011602 classical (c) SDRs; Region: SDR_c; cd05233 637380011603 NAD(P) binding site [chemical binding]; other site 637380011604 active site 637380011605 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 637380011606 Ligand Binding Site [chemical binding]; other site 637380011607 argininosuccinate lyase; Provisional; Region: PRK00855 637380011608 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 637380011609 active sites [active] 637380011610 tetramer interface [polypeptide binding]; other site 637380011611 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 637380011612 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 637380011613 ANP binding site [chemical binding]; other site 637380011614 Substrate Binding Site II [chemical binding]; other site 637380011615 Substrate Binding Site I [chemical binding]; other site 637380011616 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637380011617 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637380011618 EcsC protein family; Region: EcsC; pfam12787 637380011619 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 637380011620 nudix motif; other site 637380011621 Acetokinase family; Region: Acetate_kinase; cl01029 637380011622 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 637380011623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380011624 S-adenosylmethionine binding site [chemical binding]; other site 637380011625 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 637380011626 dimer interface [polypeptide binding]; other site 637380011627 catalytic triad [active] 637380011628 peroxidatic and resolving cysteines [active] 637380011629 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 637380011630 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 637380011631 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 637380011632 ATP-NAD kinase; Region: NAD_kinase; pfam01513 637380011633 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 637380011634 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 637380011635 active site 637380011636 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 637380011637 dimer interface [polypeptide binding]; other site 637380011638 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 637380011639 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 637380011640 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 637380011641 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 637380011642 THUMP domain; Region: THUMP; cl12076 637380011643 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 637380011644 Ligand Binding Site [chemical binding]; other site 637380011645 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 637380011646 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637380011647 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637380011648 catalytic residue [active] 637380011649 septation ring formation regulator EzrA; Provisional; Region: PRK04778 637380011650 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637380011651 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380011652 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637380011653 dimerization interface [polypeptide binding]; other site 637380011654 EamA-like transporter family; Region: EamA; cl01037 637380011655 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 637380011656 EamA-like transporter family; Region: EamA; cl01037 637380011657 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380011658 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380011659 GAF domain; Region: GAF; cl00853 637380011660 methionine gamma-lyase; Provisional; Region: PRK06767 637380011661 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 637380011662 homodimer interface [polypeptide binding]; other site 637380011663 substrate-cofactor binding pocket; other site 637380011664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380011665 catalytic residue [active] 637380011666 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 637380011667 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 637380011668 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637380011669 RNA binding surface [nucleotide binding]; other site 637380011670 Proteins of 100 residues with WXG; Region: WXG100; cl02005 637380011671 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 637380011672 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 637380011673 active site 637380011674 HIGH motif; other site 637380011675 dimer interface [polypeptide binding]; other site 637380011676 KMSKS motif; other site 637380011677 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637380011678 RNA binding surface [nucleotide binding]; other site 637380011679 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 637380011680 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637380011681 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 637380011682 DNA binding residues [nucleotide binding] 637380011683 acetyl-CoA synthetase; Provisional; Region: PRK04319 637380011684 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 637380011685 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 637380011686 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380011687 FOG: CBS domain [General function prediction only]; Region: COG0517 637380011688 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 637380011689 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 637380011690 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 637380011691 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 637380011692 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637380011693 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380011694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380011695 active site 637380011696 phosphorylation site [posttranslational modification] 637380011697 intermolecular recognition site; other site 637380011698 dimerization interface [polypeptide binding]; other site 637380011699 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380011700 DNA binding site [nucleotide binding] 637380011701 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637380011702 dimerization interface [polypeptide binding]; other site 637380011703 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380011704 dimer interface [polypeptide binding]; other site 637380011705 phosphorylation site [posttranslational modification] 637380011706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380011707 ATP binding site [chemical binding]; other site 637380011708 Mg2+ binding site [ion binding]; other site 637380011709 G-X-G motif; other site 637380011710 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 637380011711 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 637380011712 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 637380011713 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637380011714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380011715 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 637380011716 catabolite control protein A; Region: ccpA; TIGR01481 637380011717 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637380011718 DNA binding site [nucleotide binding] 637380011719 domain linker motif; other site 637380011720 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 637380011721 dimerization interface [polypeptide binding]; other site 637380011722 effector binding site; other site 637380011723 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 637380011724 Protein of unknown function (DUF2847); Region: DUF2847; cl12579 637380011725 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 637380011726 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 637380011727 Protein of unknown function (DUF1200); Region: DUF1200; pfam06713 637380011728 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380011729 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380011730 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 637380011731 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 637380011732 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637380011733 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637380011734 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 637380011735 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_B; cd01571 637380011736 active site 637380011737 ribonuclease E; Reviewed; Region: rne; PRK10811 637380011738 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380011739 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 637380011740 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 637380011741 putative tRNA-binding site [nucleotide binding]; other site 637380011742 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 637380011743 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 637380011744 catalytic residues [active] 637380011745 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 637380011746 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 637380011747 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 637380011748 oligomer interface [polypeptide binding]; other site 637380011749 active site 637380011750 metal binding site [ion binding]; metal-binding site 637380011751 Predicted small secreted protein [Function unknown]; Region: COG5584 637380011752 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380011753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380011754 S-adenosylmethionine binding site [chemical binding]; other site 637380011755 Phosphotransferase enzyme family; Region: APH; pfam01636 637380011756 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637380011757 active site 637380011758 substrate binding site [chemical binding]; other site 637380011759 ATP binding site [chemical binding]; other site 637380011760 pullulanase, type I; Region: pulA_typeI; TIGR02104 637380011761 Pullulanase domain N-terminus. Pullulanase (AKA dextrinase; alpha-dextrin endo-1,6-alpha glucosidase) is an enzyme with action similar to that of isoamylase; it cleaves 1,6-alpha-glucosidic linkages in pullulan, amylopectin, and glycogen, and in alpha-...; Region: Pullulanase_N_term; cd02860 637380011762 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 637380011763 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 637380011764 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 637380011765 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 637380011766 dipeptidase PepV; Reviewed; Region: PRK07318 637380011767 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 637380011768 active site 637380011769 metal binding site [ion binding]; metal-binding site 637380011770 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380011771 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 637380011772 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 637380011773 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 637380011774 active site 637380011775 uracil binding [chemical binding]; other site 637380011776 stage V sporulation protein B; Region: spore_V_B; TIGR02900 637380011777 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 637380011778 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380011779 flavoprotein, HI0933 family; Region: TIGR00275 637380011780 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637380011781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380011782 putative substrate translocation pore; other site 637380011783 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637380011784 dimerization interface [polypeptide binding]; other site 637380011785 putative DNA binding site [nucleotide binding]; other site 637380011786 putative Zn2+ binding site [ion binding]; other site 637380011787 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 637380011788 putative hydrophobic ligand binding site [chemical binding]; other site 637380011789 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 637380011790 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 637380011791 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 637380011792 glucose-1-dehydrogenase; Provisional; Region: PRK08936 637380011793 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 637380011794 NAD binding site [chemical binding]; other site 637380011795 homodimer interface [polypeptide binding]; other site 637380011796 active site 637380011797 Sugar transport protein; Region: Sugar_transport; pfam06800 637380011798 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 637380011799 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 637380011800 MoaE interaction surface [polypeptide binding]; other site 637380011801 MoeB interaction surface [polypeptide binding]; other site 637380011802 thiocarboxylated glycine; other site 637380011803 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 637380011804 MoaE homodimer interface [polypeptide binding]; other site 637380011805 MoaD interaction [polypeptide binding]; other site 637380011806 active site residues [active] 637380011807 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 637380011808 Probable transposase; Region: OrfB_IS605; pfam01385 637380011809 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 637380011810 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa...; Region: MobB; cd03116 637380011811 Walker A motif; other site 637380011812 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 637380011813 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 637380011814 dimer interface [polypeptide binding]; other site 637380011815 putative functional site; other site 637380011816 putative MPT binding site; other site 637380011817 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 637380011818 trimer interface [polypeptide binding]; other site 637380011819 dimer interface [polypeptide binding]; other site 637380011820 putative active site [active] 637380011821 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 637380011822 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 637380011823 ATP binding site [chemical binding]; other site 637380011824 substrate interface [chemical binding]; other site 637380011825 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 637380011826 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 637380011827 FeS/SAM binding site; other site 637380011828 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 637380011829 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 637380011830 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 637380011831 active site residue [active] 637380011832 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380011833 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 637380011834 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 637380011835 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380011836 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 637380011837 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 637380011838 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 637380011839 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 637380011840 HIGH motif; other site 637380011841 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 637380011842 active site 637380011843 KMSKS motif; other site 637380011844 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 637380011845 tRNA binding surface [nucleotide binding]; other site 637380011846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380011847 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637380011848 putative substrate translocation pore; other site 637380011849 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 637380011850 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 637380011851 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 637380011852 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380011853 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 637380011854 Phage integrase family; Region: Phage_integrase; pfam00589 637380011855 Int/Topo IB signature motif; other site 637380011856 FtsX-like permease family; Region: FtsX; pfam02687 637380011857 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637380011858 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637380011859 Walker A/P-loop; other site 637380011860 ATP binding site [chemical binding]; other site 637380011861 Q-loop/lid; other site 637380011862 ABC transporter signature motif; other site 637380011863 Walker B; other site 637380011864 D-loop; other site 637380011865 H-loop/switch region; other site 637380011866 Protein of unknown function (DUF418); Region: DUF418; cl12135 637380011867 Protein of unknown function (DUF418); Region: DUF418; cl12135 637380011868 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 637380011869 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 637380011870 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 637380011871 FeS/SAM binding site; other site 637380011872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380011873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380011874 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 637380011875 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 637380011876 Walker A/P-loop; other site 637380011877 ATP binding site [chemical binding]; other site 637380011878 Q-loop/lid; other site 637380011879 ABC transporter signature motif; other site 637380011880 Walker B; other site 637380011881 D-loop; other site 637380011882 H-loop/switch region; other site 637380011883 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 637380011884 aspartate racemase; Region: asp_race; TIGR00035 637380011885 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 637380011886 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 637380011887 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 637380011888 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380011889 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380011890 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 637380011891 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 637380011892 trimer interface [polypeptide binding]; other site 637380011893 putative metal binding site [ion binding]; other site 637380011894 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 637380011895 active site 637380011896 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 637380011897 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814 637380011898 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 637380011899 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 637380011900 GTP binding site [chemical binding]; other site 637380011901 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 637380011902 MPT binding site; other site 637380011903 trimer interface [polypeptide binding]; other site 637380011904 S-adenosylmethionine synthetase; Validated; Region: PRK05250 637380011905 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 637380011906 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 637380011907 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 637380011908 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 637380011909 active site 637380011910 substrate-binding site [chemical binding]; other site 637380011911 metal-binding site [ion binding] 637380011912 ATP binding site [chemical binding]; other site 637380011913 ATP synthase I chain; Region: ATP_synt_I; cl09170 637380011914 EamA-like transporter family; Region: EamA; cl01037 637380011915 EamA-like transporter family; Region: EamA; cl01037 637380011916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 637380011917 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 637380011918 sensory histidine kinase AtoS; Provisional; Region: PRK11360 637380011919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380011920 ATP binding site [chemical binding]; other site 637380011921 Mg2+ binding site [ion binding]; other site 637380011922 G-X-G motif; other site 637380011923 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380011924 dimer interface [polypeptide binding]; other site 637380011925 phosphorylation site [posttranslational modification] 637380011926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380011927 ATP binding site [chemical binding]; other site 637380011928 Mg2+ binding site [ion binding]; other site 637380011929 G-X-G motif; other site 637380011930 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380011931 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637380011932 Secretory lipase; Region: LIP; pfam03583 637380011933 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 637380011934 Sulfatase; Region: Sulfatase; cl10460 637380011935 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 637380011936 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380011937 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 637380011938 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 637380011939 Walker A/P-loop; other site 637380011940 ATP binding site [chemical binding]; other site 637380011941 Q-loop/lid; other site 637380011942 ABC transporter signature motif; other site 637380011943 Walker B; other site 637380011944 D-loop; other site 637380011945 H-loop/switch region; other site 637380011946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 637380011947 dimer interface [polypeptide binding]; other site 637380011948 conserved gate region; other site 637380011949 putative PBP binding loops; other site 637380011950 ABC-ATPase subunit interface; other site 637380011951 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 637380011952 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637380011953 motif II; other site 637380011954 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 637380011955 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 637380011956 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 637380011957 nudix motif; other site 637380011958 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 637380011959 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 637380011960 Domain of unknown function DUF37; Region: DUF37; cl00506 637380011961 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 637380011962 active site clefts [active] 637380011963 zinc binding site [ion binding]; other site 637380011964 dimer interface [polypeptide binding]; other site 637380011965 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 637380011966 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 637380011967 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 637380011968 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 637380011969 S-layer homology domain; Region: SLH; pfam00395 637380011970 S-layer homology domain; Region: SLH; pfam00395 637380011971 S-layer homology domain; Region: SLH; pfam00395 637380011972 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 637380011973 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 637380011974 putative active site [active] 637380011975 Uncharacterized conserved protein [Function unknown]; Region: COG1284 637380011976 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637380011977 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 637380011978 Predicted membrane protein [Function unknown]; Region: COG3766 637380011979 phage shock protein PspA; Provisional; Region: PRK10698 637380011980 PspA/IM30 family; Region: PspA_IM30; pfam04012 637380011981 hypothetical protein; Provisional; Region: PRK06760; cl11698 637380011982 Proteins of 100 residues with WXG; Region: WXG100; cl02005 637380011983 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 637380011984 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 637380011985 G1 box; other site 637380011986 GTP/Mg2+ binding site [chemical binding]; other site 637380011987 Switch I region; other site 637380011988 G2 box; other site 637380011989 G3 box; other site 637380011990 Switch II region; other site 637380011991 G4 box; other site 637380011992 G5 box; other site 637380011993 Nucleoside recognition; Region: Gate; cl00486 637380011994 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 637380011995 Nucleoside recognition; Region: Gate; cl00486 637380011996 FeoA domain; Region: FeoA; cl00838 637380011997 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl01588 637380011998 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637380011999 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637380012000 dimerization interface [polypeptide binding]; other site 637380012001 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380012002 dimer interface [polypeptide binding]; other site 637380012003 phosphorylation site [posttranslational modification] 637380012004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380012005 ATP binding site [chemical binding]; other site 637380012006 Mg2+ binding site [ion binding]; other site 637380012007 G-X-G motif; other site 637380012008 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380012009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380012010 active site 637380012011 phosphorylation site [posttranslational modification] 637380012012 intermolecular recognition site; other site 637380012013 dimerization interface [polypeptide binding]; other site 637380012014 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380012015 DNA binding site [nucleotide binding] 637380012016 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase_D_4; cd05828 637380012017 active site 637380012018 catalytic site [active] 637380012019 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 637380012020 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 637380012021 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 637380012022 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 637380012023 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 637380012024 FtsX-like permease family; Region: FtsX; pfam02687 637380012025 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637380012026 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637380012027 Walker A/P-loop; other site 637380012028 ATP binding site [chemical binding]; other site 637380012029 Q-loop/lid; other site 637380012030 ABC transporter signature motif; other site 637380012031 Walker B; other site 637380012032 D-loop; other site 637380012033 H-loop/switch region; other site 637380012034 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 637380012035 putative hydrophobic ligand binding site [chemical binding]; other site 637380012036 protein interface [polypeptide binding]; other site 637380012037 gate; other site 637380012038 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637380012039 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 637380012040 active site 637380012041 catalytic tetrad [active] 637380012042 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 637380012043 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 637380012044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380012045 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 637380012046 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637380012047 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637380012048 YolD-like protein; Region: YolD; pfam08863 637380012049 FtsX-like permease family; Region: FtsX; pfam02687 637380012050 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637380012051 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637380012052 Walker A/P-loop; other site 637380012053 ATP binding site [chemical binding]; other site 637380012054 Q-loop/lid; other site 637380012055 ABC transporter signature motif; other site 637380012056 Walker B; other site 637380012057 D-loop; other site 637380012058 H-loop/switch region; other site 637380012059 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637380012060 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637380012061 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 637380012062 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 637380012063 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 637380012064 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 637380012065 Walker A/P-loop; other site 637380012066 ATP binding site [chemical binding]; other site 637380012067 Q-loop/lid; other site 637380012068 ABC transporter signature motif; other site 637380012069 Walker B; other site 637380012070 D-loop; other site 637380012071 H-loop/switch region; other site 637380012072 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 637380012073 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637380012074 dimerization interface [polypeptide binding]; other site 637380012075 putative DNA binding site [nucleotide binding]; other site 637380012076 putative Zn2+ binding site [ion binding]; other site 637380012077 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380012078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380012079 active site 637380012080 phosphorylation site [posttranslational modification] 637380012081 intermolecular recognition site; other site 637380012082 dimerization interface [polypeptide binding]; other site 637380012083 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380012084 DNA binding site [nucleotide binding] 637380012085 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637380012086 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 637380012087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380012088 ATP binding site [chemical binding]; other site 637380012089 Mg2+ binding site [ion binding]; other site 637380012090 G-X-G motif; other site 637380012091 FtsX-like permease family; Region: FtsX; pfam02687 637380012092 FtsX-like permease family; Region: FtsX; pfam02687 637380012093 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637380012094 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637380012095 Walker A/P-loop; other site 637380012096 ATP binding site [chemical binding]; other site 637380012097 Q-loop/lid; other site 637380012098 ABC transporter signature motif; other site 637380012099 Walker B; other site 637380012100 D-loop; other site 637380012101 H-loop/switch region; other site 637380012102 FtsX-like permease family; Region: FtsX; pfam02687 637380012103 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 637380012104 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380012105 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380012106 gluconate transporter; Region: gntP; TIGR00791 637380012107 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 637380012108 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637380012109 DNA-binding site [nucleotide binding]; DNA binding site 637380012110 UTRA domain; Region: UTRA; cl06649 637380012111 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 637380012112 substrate binding site [chemical binding]; other site 637380012113 ATP binding site [chemical binding]; other site 637380012114 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 637380012115 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637380012116 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 637380012117 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 637380012118 active site 637380012119 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 637380012120 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 637380012121 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 637380012122 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380012123 dimer interface [polypeptide binding]; other site 637380012124 phosphorylation site [posttranslational modification] 637380012125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380012126 ATP binding site [chemical binding]; other site 637380012127 Mg2+ binding site [ion binding]; other site 637380012128 G-X-G motif; other site 637380012129 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380012130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380012131 active site 637380012132 phosphorylation site [posttranslational modification] 637380012133 intermolecular recognition site; other site 637380012134 dimerization interface [polypeptide binding]; other site 637380012135 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380012136 DNA binding site [nucleotide binding] 637380012137 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 637380012138 o-succinylbenzoic acid (OSB) synthetase; Region: menC_lowGC/arch; TIGR01928 637380012139 active site 637380012140 octamer interface [polypeptide binding]; other site 637380012141 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 637380012142 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 637380012143 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 637380012144 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 637380012145 substrate binding site [chemical binding]; other site 637380012146 oxyanion hole (OAH) forming residues; other site 637380012147 trimer interface [polypeptide binding]; other site 637380012148 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 637380012149 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 637380012150 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380012151 nucleophilic elbow; other site 637380012152 catalytic triad; other site 637380012153 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 637380012154 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 637380012155 dimer interface [polypeptide binding]; other site 637380012156 tetramer interface [polypeptide binding]; other site 637380012157 PYR/PP interface [polypeptide binding]; other site 637380012158 TPP binding site [chemical binding]; other site 637380012159 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637380012160 TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key role in the menaquinone biosynthetic pathway, converting...; Region: TPP_SHCHC_synthase; cd02009 637380012161 TPP-binding site; other site 637380012162 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 637380012163 chorismate binding enzyme; Region: Chorismate_bind; cl10555 637380012164 UbiA prenyltransferase family; Region: UbiA; cl00337 637380012165 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 637380012166 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 637380012167 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 637380012168 DNA-binding site [nucleotide binding]; DNA binding site 637380012169 RNA-binding motif; other site 637380012170 Protein of unknown function DUF124; Region: DUF124; cl00884 637380012171 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 637380012172 active site flap/lid [active] 637380012173 nucleophilic elbow; other site 637380012174 catalytic triad [active] 637380012175 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 637380012176 homodimer interface [polypeptide binding]; other site 637380012177 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 637380012178 active site pocket [active] 637380012179 glycogen synthase; Provisional; Region: glgA; PRK00654 637380012180 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 637380012181 ADP-binding pocket [chemical binding]; other site 637380012182 homodimer interface [polypeptide binding]; other site 637380012183 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 637380012184 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 637380012185 ligand binding site [chemical binding]; other site 637380012186 oligomer interface [polypeptide binding]; other site 637380012187 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 637380012188 dimer interface [polypeptide binding]; other site 637380012189 N-terminal domain interface [polypeptide binding]; other site 637380012190 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 637380012191 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 637380012192 ligand binding site [chemical binding]; other site 637380012193 oligomer interface [polypeptide binding]; other site 637380012194 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 637380012195 dimer interface [polypeptide binding]; other site 637380012196 N-terminal domain interface [polypeptide binding]; other site 637380012197 sulfate 1 binding site; other site 637380012198 glycogen branching enzyme; Provisional; Region: PRK12313 637380012199 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 637380012200 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 637380012201 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 637380012202 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 637380012203 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 637380012204 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 637380012205 putative active site [active] 637380012206 catalytic triad [active] 637380012207 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 637380012208 PA/protease domain interface [polypeptide binding]; other site 637380012209 putative integrin binding motif; other site 637380012210 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 637380012211 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 637380012212 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 637380012213 dockerin binding interface; other site 637380012214 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 637380012215 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 637380012216 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637380012217 NAD binding site [chemical binding]; other site 637380012218 dimer interface [polypeptide binding]; other site 637380012219 substrate binding site [chemical binding]; other site 637380012220 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 637380012221 MgtC family; Region: MgtC; cl12207 637380012222 Ion channel; Region: Ion_trans_2; cl11596 637380012223 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 637380012224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380012225 YugN-like family; Region: YugN; pfam08868 637380012226 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 637380012227 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 637380012228 active site 637380012229 dimer interface [polypeptide binding]; other site 637380012230 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 637380012231 dimer interface [polypeptide binding]; other site 637380012232 active site 637380012233 Domain of unknown function (DUF378); Region: DUF378; cl00943 637380012234 general stress protein 13; Validated; Region: PRK08059 637380012235 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 637380012236 RNA binding site [nucleotide binding]; other site 637380012237 aspartate aminotransferase; Provisional; Region: PRK08361 637380012238 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637380012239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380012240 homodimer interface [polypeptide binding]; other site 637380012241 catalytic residue [active] 637380012242 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380012243 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 637380012244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380012245 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380012246 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637380012247 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 637380012248 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 637380012249 aspartate aminotransferase; Provisional; Region: PRK08361 637380012250 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637380012251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380012252 homodimer interface [polypeptide binding]; other site 637380012253 catalytic residue [active] 637380012254 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 637380012255 E-class dimer interface [polypeptide binding]; other site 637380012256 P-class dimer interface [polypeptide binding]; other site 637380012257 active site 637380012258 Cu2+ binding site [ion binding]; other site 637380012259 Zn2+ binding site [ion binding]; other site 637380012260 Kinase associated protein B; Region: KapB; pfam08810 637380012261 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 637380012262 active site 637380012263 substrate binding site [chemical binding]; other site 637380012264 catalytic site [active] 637380012265 arsenical pump membrane protein; Provisional; Region: PRK15445 637380012266 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 637380012267 transmembrane helices; other site 637380012268 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 637380012269 Active site [active] 637380012270 glycyl-tRNA synthetase; Provisional; Region: PRK04173 637380012271 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 637380012272 motif 1; other site 637380012273 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the...; Region: GlyRS-like_core; cd00774 637380012274 active site 637380012275 motif 2; other site 637380012276 motif 3; other site 637380012277 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 637380012278 anticodon binding site; other site 637380012279 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 637380012280 CoenzymeA binding site [chemical binding]; other site 637380012281 subunit interaction site [polypeptide binding]; other site 637380012282 PHB binding site; other site 637380012283 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 637380012284 BioY family; Region: BioY; cl00560 637380012285 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 637380012286 active site 637380012287 tetramer interface [polypeptide binding]; other site 637380012288 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 637380012289 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 637380012290 active site 637380012291 substrate binding site [chemical binding]; other site 637380012292 metal binding site [ion binding]; metal-binding site 637380012293 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 637380012294 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 637380012295 multifunctional aminopeptidase A; Provisional; Region: PRK00913 637380012296 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 637380012297 interface (dimer of trimers) [polypeptide binding]; other site 637380012298 Substrate-binding/catalytic site; other site 637380012299 Zn-binding sites [ion binding]; other site 637380012300 3D domain; Region: 3D; cl01439 637380012301 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 637380012302 nudix motif; other site 637380012303 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 637380012304 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380012305 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 637380012306 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380012307 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380012308 Domain of unknown function DUF11; Region: DUF11; cl03172 637380012309 Domain of unknown function DUF11; Region: DUF11; cl03172 637380012310 Domain of unknown function DUF11; Region: DUF11; cl03172 637380012311 Domain of unknown function DUF11; Region: DUF11; cl03172 637380012312 Domain of unknown function DUF11; Region: DUF11; cl03172 637380012313 Domain of unknown function DUF11; Region: DUF11; cl03172 637380012314 Domain of unknown function DUF11; Region: DUF11; cl03172 637380012315 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 637380012316 Transposase domain (DUF772); Region: DUF772; cl12084 637380012317 H+ Antiporter protein; Region: 2A0121; TIGR00900 637380012318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380012319 putative substrate translocation pore; other site 637380012320 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 637380012321 Protein of unknown function (DUF523); Region: DUF523; cl00733 637380012322 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 637380012323 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 637380012324 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 637380012325 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 637380012326 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 637380012327 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 637380012328 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380012329 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 637380012330 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 637380012331 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380012332 Walker A/P-loop; other site 637380012333 ATP binding site [chemical binding]; other site 637380012334 Q-loop/lid; other site 637380012335 ABC transporter signature motif; other site 637380012336 Walker B; other site 637380012337 D-loop; other site 637380012338 H-loop/switch region; other site 637380012339 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 637380012340 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 637380012341 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 637380012342 PhnA protein; Region: PhnA; pfam03831 637380012343 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 637380012344 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 637380012345 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 637380012346 active site 637380012347 NTP binding site [chemical binding]; other site 637380012348 metal binding triad [ion binding]; metal-binding site 637380012349 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 637380012350 NifU-like domain; Region: NifU; cl00484 637380012351 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 637380012352 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 637380012353 tetramer interfaces [polypeptide binding]; other site 637380012354 binuclear metal-binding site [ion binding]; other site 637380012355 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380012356 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 637380012357 FtsX-like permease family; Region: FtsX; pfam02687 637380012358 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 637380012359 FtsX-like permease family; Region: FtsX; pfam02687 637380012360 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637380012361 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637380012362 Walker A/P-loop; other site 637380012363 ATP binding site [chemical binding]; other site 637380012364 Q-loop/lid; other site 637380012365 ABC transporter signature motif; other site 637380012366 Walker B; other site 637380012367 D-loop; other site 637380012368 H-loop/switch region; other site 637380012369 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 637380012370 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 637380012371 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637380012372 active site 637380012373 motif I; other site 637380012374 motif II; other site 637380012375 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637380012376 Predicted transcriptional regulator [Transcription]; Region: COG2345 637380012377 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380012378 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 637380012379 Protein of unknown function DUF86; Region: DUF86; cl01031 637380012380 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins [Carbohydrate transport and metabolism]; Region: GlpX; COG1494 637380012381 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 637380012382 putative active site [active] 637380012383 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 637380012384 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 637380012385 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637380012386 RNA binding surface [nucleotide binding]; other site 637380012387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380012388 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 637380012389 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 637380012390 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 637380012391 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 637380012392 DNA binding residues [nucleotide binding] 637380012393 dimer interface [polypeptide binding]; other site 637380012394 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 637380012395 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 637380012396 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637380012397 catalytic core [active] 637380012398 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 637380012399 putative deacylase active site [active] 637380012400 lipoyl synthase; Provisional; Region: PRK05481 637380012401 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 637380012402 FeS/SAM binding site; other site 637380012403 Peptidase family M23; Region: Peptidase_M23; pfam01551 637380012404 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 637380012405 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 637380012406 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 637380012407 active site 637380012408 metal binding site [ion binding]; metal-binding site 637380012409 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 637380012410 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380012411 VanZ like family; Region: VanZ; cl01971 637380012412 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 637380012413 FeS assembly protein SufB; Region: sufB; TIGR01980 637380012414 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 637380012415 trimerization site [polypeptide binding]; other site 637380012416 active site 637380012417 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 637380012418 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 637380012419 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637380012420 catalytic residue [active] 637380012421 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 637380012422 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 637380012423 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 637380012424 FeS assembly ATPase SufC; Region: sufC; TIGR01978 637380012425 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 637380012426 Walker A/P-loop; other site 637380012427 ATP binding site [chemical binding]; other site 637380012428 Q-loop/lid; other site 637380012429 ABC transporter signature motif; other site 637380012430 Walker B; other site 637380012431 D-loop; other site 637380012432 H-loop/switch region; other site 637380012433 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380012434 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380012435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 637380012436 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 637380012437 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 637380012438 Walker A/P-loop; other site 637380012439 ATP binding site [chemical binding]; other site 637380012440 Q-loop/lid; other site 637380012441 ABC transporter signature motif; other site 637380012442 Walker B; other site 637380012443 D-loop; other site 637380012444 H-loop/switch region; other site 637380012445 NIL domain; Region: NIL; pfam09383 637380012446 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 637380012447 catalytic residues [active] 637380012448 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in...; Region: TOPRIM_RNase_M5_like; cd01027 637380012449 putative active site [active] 637380012450 putative metal binding site [ion binding]; other site 637380012451 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 637380012452 lipoyl attachment site [posttranslational modification]; other site 637380012453 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 637380012454 putative ArsC-like catalytic residues; other site 637380012455 putative TRX-like catalytic residues [active] 637380012456 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 637380012457 active site 637380012458 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637380012459 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 637380012460 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 637380012461 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637380012462 NAD binding site [chemical binding]; other site 637380012463 dimer interface [polypeptide binding]; other site 637380012464 substrate binding site [chemical binding]; other site 637380012465 Coat F domain; Region: Coat_F; cl02368 637380012466 tetracycline repressor protein TetR; Provisional; Region: PRK13756 637380012467 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380012468 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 637380012469 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 637380012470 active site 637380012471 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 637380012472 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 637380012473 dimer interface [polypeptide binding]; other site 637380012474 active site 637380012475 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 637380012476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380012477 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 637380012478 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 637380012479 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 637380012480 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 637380012481 substrate binding site [chemical binding]; other site 637380012482 oxyanion hole (OAH) forming residues; other site 637380012483 Beta-lactamase; Region: Beta-lactamase; cl01009 637380012484 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 637380012485 Proline dehydrogenase; Region: Pro_dh; cl03282 637380012486 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 637380012487 Domain of unknown function DUF77; Region: DUF77; cl00307 637380012488 Cache domain; Region: Cache_1; pfam02743 637380012489 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 637380012490 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637380012491 dimerization interface [polypeptide binding]; other site 637380012492 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637380012493 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 637380012494 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380012495 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 637380012496 C-terminal domain interface [polypeptide binding]; other site 637380012497 sugar binding site [chemical binding]; other site 637380012498 TQXA domain; Region: TQXA_dom; TIGR03934 637380012499 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380012500 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380012501 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380012502 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380012503 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 637380012504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380012505 putative substrate translocation pore; other site 637380012506 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 637380012507 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 637380012508 MAEBL; Provisional; Region: PTZ00121 637380012509 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 637380012510 Uncharacterized conserved protein [Function unknown]; Region: COG1284 637380012511 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 637380012512 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 637380012513 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380012514 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380012515 hypothetical protein; Provisional; Region: PRK06758 637380012516 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 637380012517 active site 637380012518 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380012519 non-specific DNA binding site [nucleotide binding]; other site 637380012520 salt bridge; other site 637380012521 sequence-specific DNA binding site [nucleotide binding]; other site 637380012522 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 637380012523 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 637380012524 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380012525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380012526 active site 637380012527 phosphorylation site [posttranslational modification] 637380012528 intermolecular recognition site; other site 637380012529 dimerization interface [polypeptide binding]; other site 637380012530 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380012531 DNA binding site [nucleotide binding] 637380012532 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637380012533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380012534 dimer interface [polypeptide binding]; other site 637380012535 phosphorylation site [posttranslational modification] 637380012536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380012537 ATP binding site [chemical binding]; other site 637380012538 Mg2+ binding site [ion binding]; other site 637380012539 G-X-G motif; other site 637380012540 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 637380012541 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 637380012542 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 637380012543 active site 637380012544 HIGH motif; other site 637380012545 KMSKS motif; other site 637380012546 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 637380012547 tRNA binding surface [nucleotide binding]; other site 637380012548 anticodon binding site; other site 637380012549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380012550 S-adenosylmethionine binding site [chemical binding]; other site 637380012551 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 637380012552 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637380012553 dimerization interface [polypeptide binding]; other site 637380012554 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637380012555 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 637380012556 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 637380012557 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637380012558 dimerization interface [polypeptide binding]; other site 637380012559 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637380012560 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 637380012561 Domain of unknown function DUF59; Region: DUF59; cl00941 637380012562 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 637380012563 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 637380012564 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 637380012565 active site 637380012566 Zn binding site [ion binding]; other site 637380012567 Cupin domain; Region: Cupin_2; cl09118 637380012568 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380012569 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 637380012570 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 637380012571 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 637380012572 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380012573 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 637380012574 Ferritin-like domain; Region: Ferritin; pfam00210 637380012575 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 637380012576 dimerization interface [polypeptide binding]; other site 637380012577 DPS ferroxidase diiron center [ion binding]; other site 637380012578 ion pore; other site 637380012579 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 637380012580 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 637380012581 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 637380012582 Ferritin-like domain; Region: Ferritin; pfam00210 637380012583 ferroxidase diiron center [ion binding]; other site 637380012584 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 637380012585 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 637380012586 Nucleoside recognition; Region: Gate; cl00486 637380012587 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 637380012588 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 637380012589 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 637380012590 Nucleoside recognition; Region: Gate; cl00486 637380012591 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 637380012592 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 637380012593 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 637380012594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380012595 active site 637380012596 Viral enhancin protein; Region: Enhancin; pfam03272 637380012597 Viral enhancin protein; Region: Enhancin; pfam03272 637380012598 TQXA domain; Region: TQXA_dom; TIGR03934 637380012599 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 637380012600 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637380012601 active site 637380012602 catalytic tetrad [active] 637380012603 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 637380012604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380012605 putative substrate translocation pore; other site 637380012606 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380012607 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 637380012608 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 637380012609 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380012610 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 637380012611 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 637380012612 active site 637380012613 HIGH motif; other site 637380012614 dimer interface [polypeptide binding]; other site 637380012615 KMSKS motif; other site 637380012616 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637380012617 RNA binding surface [nucleotide binding]; other site 637380012618 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 637380012619 FAD binding domain; Region: FAD_binding_4; pfam01565 637380012620 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 637380012621 SET domain; Region: SET; cl02566 637380012622 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637380012623 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 637380012624 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 637380012625 putative catalytic site [active] 637380012626 putative metal binding site [ion binding]; other site 637380012627 putative phosphate binding site [ion binding]; other site 637380012628 CrcB-like protein; Region: CRCB; cl09114 637380012629 CrcB-like protein; Region: CRCB; cl09114 637380012630 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637380012631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380012632 Phosphate-starvation-inducible E; Region: PsiE; cl01264 637380012633 Nuclease-related domain; Region: NERD; pfam08378 637380012634 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 637380012635 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 637380012636 Walker A/P-loop; other site 637380012637 ATP binding site [chemical binding]; other site 637380012638 Q-loop/lid; other site 637380012639 ABC transporter signature motif; other site 637380012640 Walker B; other site 637380012641 D-loop; other site 637380012642 H-loop/switch region; other site 637380012643 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 637380012644 ABC-ATPase subunit interface; other site 637380012645 dimer interface [polypeptide binding]; other site 637380012646 putative PBP binding regions; other site 637380012647 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 637380012648 ABC-ATPase subunit interface; other site 637380012649 dimer interface [polypeptide binding]; other site 637380012650 putative PBP binding regions; other site 637380012651 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 637380012652 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 637380012653 putative ligand binding residues [chemical binding]; other site 637380012654 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380012655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380012656 active site 637380012657 phosphorylation site [posttranslational modification] 637380012658 intermolecular recognition site; other site 637380012659 dimerization interface [polypeptide binding]; other site 637380012660 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380012661 DNA binding site [nucleotide binding] 637380012662 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637380012663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380012664 ATP binding site [chemical binding]; other site 637380012665 Mg2+ binding site [ion binding]; other site 637380012666 G-X-G motif; other site 637380012667 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380012668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380012669 active site 637380012670 phosphorylation site [posttranslational modification] 637380012671 intermolecular recognition site; other site 637380012672 dimerization interface [polypeptide binding]; other site 637380012673 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380012674 DNA binding site [nucleotide binding] 637380012675 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637380012676 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637380012677 Walker A/P-loop; other site 637380012678 ATP binding site [chemical binding]; other site 637380012679 Q-loop/lid; other site 637380012680 ABC transporter signature motif; other site 637380012681 Walker B; other site 637380012682 D-loop; other site 637380012683 H-loop/switch region; other site 637380012684 VanZ like family; Region: VanZ; cl01971 637380012685 RDD family; Region: RDD; cl00746 637380012686 Predicted membrane protein [Function unknown]; Region: COG2311 637380012687 Protein of unknown function (DUF418); Region: DUF418; cl12135 637380012688 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637380012689 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637380012690 Walker A/P-loop; other site 637380012691 ATP binding site [chemical binding]; other site 637380012692 Q-loop/lid; other site 637380012693 ABC transporter signature motif; other site 637380012694 Walker B; other site 637380012695 D-loop; other site 637380012696 H-loop/switch region; other site 637380012697 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 637380012698 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 637380012699 SmpB-tmRNA interface; other site 637380012700 ribonuclease R; Region: RNase_R; TIGR02063 637380012701 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 637380012702 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 637380012703 RNB domain; Region: RNB; pfam00773 637380012704 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 637380012705 RNA binding site [nucleotide binding]; other site 637380012706 Esterase/lipase [General function prediction only]; Region: COG1647 637380012707 Preprotein translocase SecG subunit; Region: SecG; cl09123 637380012708 LrgB-like family; Region: LrgB; cl00596 637380012709 LrgA family; Region: LrgA; cl00608 637380012710 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 637380012711 active site 637380012712 enolase; Provisional; Region: eno; PRK00077 637380012713 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 637380012714 dimer interface [polypeptide binding]; other site 637380012715 metal binding site [ion binding]; metal-binding site 637380012716 substrate binding pocket [chemical binding]; other site 637380012717 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 637380012718 Sulfatase; Region: Sulfatase; cl10460 637380012719 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 637380012720 substrate binding site [chemical binding]; other site 637380012721 dimer interface [polypeptide binding]; other site 637380012722 catalytic triad [active] 637380012723 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 637380012724 substrate binding site [chemical binding]; other site 637380012725 hinge regions; other site 637380012726 ADP binding site [chemical binding]; other site 637380012727 catalytic site [active] 637380012728 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 637380012729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380012730 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 637380012731 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 637380012732 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 637380012733 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 637380012734 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 637380012735 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 637380012736 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 637380012737 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 637380012738 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 637380012739 SpoVA protein; Region: SpoVA; cl04298 637380012740 stage V sporulation protein AD; Provisional; Region: PRK12404 637380012741 SpoVA protein; Region: SpoVA; cl04298 637380012742 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 637380012743 Protein of unknown function (DUF421); Region: DUF421; cl00990 637380012744 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 637380012745 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 637380012746 oligomer interface [polypeptide binding]; other site 637380012747 active site residues [active] 637380012748 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 637380012749 dimerization domain swap beta strand [polypeptide binding]; other site 637380012750 regulatory protein interface [polypeptide binding]; other site 637380012751 active site 637380012752 regulatory phosphorylation site [posttranslational modification]; other site 637380012753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 637380012754 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 637380012755 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 637380012756 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 637380012757 phosphate binding site [ion binding]; other site 637380012758 putative substrate binding pocket [chemical binding]; other site 637380012759 dimer interface [polypeptide binding]; other site 637380012760 P-loop ATPase protein family; Region: ATP_bind_2; cl10035 637380012761 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 637380012762 putative active site [active] 637380012763 nucleotide binding site [chemical binding]; other site 637380012764 nudix motif; other site 637380012765 putative metal binding site [ion binding]; other site 637380012766 Domain of unknown function (DUF368); Region: DUF368; cl00893 637380012767 Domain of unknown function (DUF368); Region: DUF368; cl00893 637380012768 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 637380012769 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380012770 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 637380012771 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637380012772 binding surface 637380012773 TPR motif; other site 637380012774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 637380012775 binding surface 637380012776 TPR motif; other site 637380012777 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-...; Region: LbH_MAT_like; cd04647 637380012778 trimer interface [polypeptide binding]; other site 637380012779 active site 637380012780 substrate binding site [chemical binding]; other site 637380012781 CoA binding site [chemical binding]; other site 637380012782 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 637380012783 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637380012784 active site 637380012785 motif I; other site 637380012786 motif II; other site 637380012787 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 637380012788 HPr kinase/phosphorylase; Provisional; Region: PRK05428 637380012789 DRTGG domain; Region: DRTGG; cl12147 637380012790 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918 637380012791 Hpr binding site; other site 637380012792 active site 637380012793 homohexamer subunit interaction site [polypeptide binding]; other site 637380012794 Membrane protein of unknown function; Region: DUF360; cl00850 637380012795 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 637380012796 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 637380012797 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 637380012798 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 637380012799 excinuclease ABC subunit B; Provisional; Region: PRK05298 637380012800 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637380012801 ATP binding site [chemical binding]; other site 637380012802 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637380012803 nucleotide binding region [chemical binding]; other site 637380012804 ATP-binding site [chemical binding]; other site 637380012805 Ultra-violet resistance protein B; Region: UvrB; pfam12344 637380012806 Transposase domain (DUF772); Region: DUF772; cl12084 637380012807 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 637380012808 DNA binding residues [nucleotide binding] 637380012809 dimer interface [polypeptide binding]; other site 637380012810 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 637380012811 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380012812 non-specific DNA binding site [nucleotide binding]; other site 637380012813 salt bridge; other site 637380012814 sequence-specific DNA binding site [nucleotide binding]; other site 637380012815 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 637380012816 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637380012817 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380012818 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 637380012819 putative dimerization interface [polypeptide binding]; other site 637380012820 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 637380012821 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 637380012822 DNA binding residues [nucleotide binding] 637380012823 putative dimer interface [polypeptide binding]; other site 637380012824 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 637380012825 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 637380012826 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380012827 D-loop; other site 637380012828 H-loop/switch region; other site 637380012829 Domain of unknown function (DUF74); Region: DUF74; cl00426 637380012830 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 637380012831 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 637380012832 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 637380012833 Walker A/P-loop; other site 637380012834 ATP binding site [chemical binding]; other site 637380012835 Q-loop/lid; other site 637380012836 ABC transporter signature motif; other site 637380012837 Walker B; other site 637380012838 D-loop; other site 637380012839 H-loop/switch region; other site 637380012840 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 637380012841 protein binding site [polypeptide binding]; other site 637380012842 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 637380012843 C-terminal peptidase (prc); Region: prc; TIGR00225 637380012844 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 637380012845 protein binding site [polypeptide binding]; other site 637380012846 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 637380012847 Catalytic dyad [active] 637380012848 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 637380012849 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 637380012850 FtsX-like permease family; Region: FtsX; pfam02687 637380012851 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 637380012852 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380012853 Walker A/P-loop; other site 637380012854 ATP binding site [chemical binding]; other site 637380012855 Q-loop/lid; other site 637380012856 ABC transporter signature motif; other site 637380012857 Walker B; other site 637380012858 D-loop; other site 637380012859 H-loop/switch region; other site 637380012860 Cytochrome c; Region: Cytochrom_C; cl11414 637380012861 peptide chain release factor 2; Provisional; Region: PRK06746 637380012862 RF-1 domain; Region: RF-1; cl02875 637380012863 RF-1 domain; Region: RF-1; cl02875 637380012864 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 637380012865 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 637380012866 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 637380012867 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 637380012868 SEC-C motif; Region: SEC-C; cl12132 637380012869 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 637380012870 30S subunit binding site; other site 637380012871 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 637380012872 DNA-binding site [nucleotide binding]; DNA binding site 637380012873 RNA-binding motif; other site 637380012874 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 637380012875 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 637380012876 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 637380012877 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637380012878 ATP binding site [chemical binding]; other site 637380012879 putative Mg++ binding site [ion binding]; other site 637380012880 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637380012881 nucleotide binding region [chemical binding]; other site 637380012882 ATP-binding site [chemical binding]; other site 637380012883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 637380012884 NlpC/P60 family; Region: NLPC_P60; cl11438 637380012885 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380012886 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 637380012887 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 637380012888 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 637380012889 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 637380012890 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 637380012891 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 637380012892 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 637380012893 active site 637380012894 homodimer interface [polypeptide binding]; other site 637380012895 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 637380012896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380012897 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 637380012898 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 637380012899 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 637380012900 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 637380012901 Mg++ binding site [ion binding]; other site 637380012902 putative catalytic motif [active] 637380012903 substrate binding site [chemical binding]; other site 637380012904 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 637380012905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 637380012906 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 637380012907 Walker A motif; other site 637380012908 ATP binding site [chemical binding]; other site 637380012909 Walker B motif; other site 637380012910 arginine finger; other site 637380012911 Transcriptional antiterminator [Transcription]; Region: COG3933 637380012912 PRD domain; Region: PRD; pfam00874 637380012913 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 637380012914 active pocket/dimerization site; other site 637380012915 active site 637380012916 phosphorylation site [posttranslational modification] 637380012917 PRD domain; Region: PRD; pfam00874 637380012918 CHRD domain; Region: CHRD; cl06473 637380012919 Chromate transporter; Region: Chromate_transp; pfam02417 637380012920 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 637380012921 Chromate transporter; Region: Chromate_transp; pfam02417 637380012922 YdjC-like protein; Region: YdjC; cl01344 637380012923 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 637380012924 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 637380012925 NAD binding site [chemical binding]; other site 637380012926 sugar binding site [chemical binding]; other site 637380012927 divalent metal binding site [ion binding]; other site 637380012928 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637380012929 dimer interface [polypeptide binding]; other site 637380012930 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 637380012931 active site 637380012932 methionine cluster; other site 637380012933 phosphorylation site [posttranslational modification] 637380012934 metal binding site [ion binding]; metal-binding site 637380012935 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637380012936 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 637380012937 active site 637380012938 P-loop; other site 637380012939 phosphorylation site [posttranslational modification] 637380012940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380012941 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 637380012942 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 637380012943 methionine cluster; other site 637380012944 active site 637380012945 phosphorylation site [posttranslational modification] 637380012946 metal binding site [ion binding]; metal-binding site 637380012947 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637380012948 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 637380012949 active site 637380012950 P-loop; other site 637380012951 phosphorylation site [posttranslational modification] 637380012952 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 637380012953 Acyltransferase family; Region: Acyl_transf_3; pfam01757 637380012954 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 637380012955 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 637380012956 Predicted membrane protein [Function unknown]; Region: COG1511 637380012957 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 637380012958 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 637380012959 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637380012960 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 637380012961 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 637380012962 putative dimerization interface [polypeptide binding]; other site 637380012963 N-terminal domain; Region: tspaseT_teng_N; TIGR01765 637380012964 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 637380012965 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 637380012966 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 637380012967 arsenical pump membrane protein; Provisional; Region: PRK15445 637380012968 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 637380012969 transmembrane helices; other site 637380012970 ThiC family; Region: ThiC; cl08031 637380012971 L-lactate permease; Region: Lactate_perm; cl00701 637380012972 Transposase; Region: DDE_Tnp_ISL3; pfam01610 637380012973 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons...; Region: RT_like; cl02808 637380012974 L-lactate permease; Region: Lactate_perm; cl00701 637380012975 glycolate transporter; Provisional; Region: PRK09695 637380012976 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017 637380012977 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 637380012978 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 637380012979 Sulfatase; Region: Sulfatase; cl10460 637380012980 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-...; Region: D-AAT_like; cd01558 637380012981 homodimer interface [polypeptide binding]; other site 637380012982 substrate-cofactor binding pocket; other site 637380012983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380012984 Aminotransferase class IV; Region: Aminotran_4; pfam01063 637380012985 catalytic residue [active] 637380012986 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 637380012987 Bacterial SH3 domain; Region: SH3_3; cl02551 637380012988 Bacterial SH3 domain; Region: SH3_3; cl02551 637380012989 Bacterial SH3 domain; Region: SH3_3; cl02551 637380012990 Bacterial SH3 domain; Region: SH3_3; cl02551 637380012991 Bacterial SH3 domain; Region: SH3_3; cl02551 637380012992 NlpC/P60 family; Region: NLPC_P60; cl11438 637380012993 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 637380012994 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 637380012995 Nucleoside recognition; Region: Gate; cl00486 637380012996 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 637380012997 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 637380012998 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 637380012999 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 637380013000 DXD motif; other site 637380013001 BCCT family transporter; Region: BCCT; cl00569 637380013002 Bacterial SH3 domain; Region: SH3_3; cl02551 637380013003 Bacterial SH3 domain; Region: SH3_3; cl02551 637380013004 3D domain; Region: 3D; cl01439 637380013005 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 637380013006 Predicted membrane protein [Function unknown]; Region: COG4640 637380013007 Double zinc ribbon; Region: DZR; pfam12773 637380013008 Double zinc ribbon; Region: DZR; pfam12773 637380013009 SNF2 Helicase protein; Region: DUF3670; pfam12419 637380013010 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 637380013011 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637380013012 ATP binding site [chemical binding]; other site 637380013013 putative Mg++ binding site [ion binding]; other site 637380013014 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637380013015 nucleotide binding region [chemical binding]; other site 637380013016 ATP-binding site [chemical binding]; other site 637380013017 VanZ like family; Region: VanZ; cl01971 637380013018 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 637380013019 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 637380013020 ComK protein; Region: ComK; cl11560 637380013021 RNA polymerase factor sigma-70; Validated; Region: PRK06759 637380013022 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637380013023 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 637380013024 DNA binding residues [nucleotide binding] 637380013025 Yip1 domain; Region: Yip1; cl12048 637380013026 Yip1 domain; Region: Yip1; cl12048 637380013027 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 637380013028 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637380013029 FtsX-like permease family; Region: FtsX; pfam02687 637380013030 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 637380013031 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 637380013032 Walker A/P-loop; other site 637380013033 ATP binding site [chemical binding]; other site 637380013034 Q-loop/lid; other site 637380013035 ABC transporter signature motif; other site 637380013036 Walker B; other site 637380013037 D-loop; other site 637380013038 H-loop/switch region; other site 637380013039 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 637380013040 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380013041 non-specific DNA binding site [nucleotide binding]; other site 637380013042 salt bridge; other site 637380013043 sequence-specific DNA binding site [nucleotide binding]; other site 637380013044 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 637380013045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380013046 putative substrate translocation pore; other site 637380013047 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637380013048 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 637380013049 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380013050 dimer interface [polypeptide binding]; other site 637380013051 phosphorylation site [posttranslational modification] 637380013052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380013053 ATP binding site [chemical binding]; other site 637380013054 Mg2+ binding site [ion binding]; other site 637380013055 G-X-G motif; other site 637380013056 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380013057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380013058 active site 637380013059 phosphorylation site [posttranslational modification] 637380013060 intermolecular recognition site; other site 637380013061 dimerization interface [polypeptide binding]; other site 637380013062 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380013063 DNA binding site [nucleotide binding] 637380013064 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 637380013065 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 637380013066 NAD binding site [chemical binding]; other site 637380013067 homodimer interface [polypeptide binding]; other site 637380013068 active site 637380013069 substrate binding site [chemical binding]; other site 637380013070 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 637380013071 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 637380013072 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 637380013073 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 637380013074 active site 637380013075 homodimer interface [polypeptide binding]; other site 637380013076 teichoic acids export protein ATP-binding subunit; Provisional; Region: tagH; PRK13545 637380013077 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 637380013078 Walker A/P-loop; other site 637380013079 ATP binding site [chemical binding]; other site 637380013080 Q-loop/lid; other site 637380013081 ABC transporter signature motif; other site 637380013082 Walker B; other site 637380013083 D-loop; other site 637380013084 H-loop/switch region; other site 637380013085 Bacterial SH3 domain; Region: SH3_3; cl02551 637380013086 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637380013087 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 637380013088 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 637380013089 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 637380013090 Heparinase II/III-like protein; Region: Hepar_II_III; cl02215 637380013091 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 637380013092 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 637380013093 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 637380013094 active site 637380013095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380013096 S-adenosylmethionine binding site [chemical binding]; other site 637380013097 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 637380013098 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 637380013099 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 637380013100 putative glycosyl transferase; Provisional; Region: PRK10307 637380013101 rod shape-determining protein Mbl; Provisional; Region: PRK13928 637380013102 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 637380013103 ATP binding site [chemical binding]; other site 637380013104 profilin binding site; other site 637380013105 Stage III sporulation protein D; Region: SpoIIID; cl11824 637380013106 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 637380013107 Peptidase family M23; Region: Peptidase_M23; pfam01551 637380013108 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637380013109 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637380013110 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 637380013111 Walker A/P-loop; other site 637380013112 ATP binding site [chemical binding]; other site 637380013113 Q-loop/lid; other site 637380013114 ABC transporter signature motif; other site 637380013115 Walker B; other site 637380013116 D-loop; other site 637380013117 H-loop/switch region; other site 637380013118 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 637380013119 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 637380013120 Walker A/P-loop; other site 637380013121 ATP binding site [chemical binding]; other site 637380013122 Q-loop/lid; other site 637380013123 ABC transporter signature motif; other site 637380013124 Walker B; other site 637380013125 D-loop; other site 637380013126 H-loop/switch region; other site 637380013127 LytTr DNA-binding domain; Region: LytTR; cl04498 637380013128 Stage II sporulation protein; Region: SpoIID; cl07201 637380013129 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 637380013130 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 637380013131 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 637380013132 hinge; other site 637380013133 active site 637380013134 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 637380013135 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 637380013136 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 637380013137 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 637380013138 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 637380013139 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 637380013140 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 637380013141 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 637380013142 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 637380013143 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 637380013144 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 637380013145 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 637380013146 4Fe-4S binding domain; Region: Fer4; cl02805 637380013147 NADH dehydrogenase; Region: NADHdh; cl00469 637380013148 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 637380013149 NADH dehydrogenase subunit C; Validated; Region: PRK07735 637380013150 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 637380013151 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 637380013152 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 637380013153 PAS domain S-box; Region: sensory_box; TIGR00229 637380013154 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637380013155 putative active site [active] 637380013156 heme pocket [chemical binding]; other site 637380013157 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637380013158 metal binding site [ion binding]; metal-binding site 637380013159 active site 637380013160 I-site; other site 637380013161 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637380013162 Protein of unknown function (DUF975); Region: DUF975; cl10504 637380013163 Protein of unknown function (DUF975); Region: DUF975; cl10504 637380013164 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 637380013165 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 637380013166 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 637380013167 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 637380013168 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 637380013169 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 637380013170 alpha subunit interaction interface [polypeptide binding]; other site 637380013171 Walker A motif; other site 637380013172 ATP binding site [chemical binding]; other site 637380013173 Walker B motif; other site 637380013174 inhibitor binding site; inhibition site 637380013175 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 637380013176 ATP synthase; Region: ATP-synt; cl00365 637380013177 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 637380013178 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 637380013179 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 637380013180 beta subunit interaction interface [polypeptide binding]; other site 637380013181 Walker A motif; other site 637380013182 ATP binding site [chemical binding]; other site 637380013183 Walker B motif; other site 637380013184 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 637380013185 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 637380013186 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 637380013187 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 637380013188 ATP synthase subunit C; Region: ATP-synt_C; cl00466 637380013189 ATP synthase A chain; Region: ATP-synt_A; cl00413 637380013190 ATP synthase I chain; Region: ATP_synt_I; cl09170 637380013191 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 637380013192 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 637380013193 dimer interface [polypeptide binding]; other site 637380013194 glycine-pyridoxal phosphate binding site [chemical binding]; other site 637380013195 active site 637380013196 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 637380013197 folate binding site [chemical binding]; other site 637380013198 Protein of unknown function (DUF436); Region: DUF436; cl01860 637380013199 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 637380013200 Low molecular weight phosphatase family; Region: LMWPc; cd00115 637380013201 Active site [active] 637380013202 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cd00210 637380013203 HPr interaction site; other site 637380013204 glycerol kinase (GK) interaction site [polypeptide binding]; other site 637380013205 active site 637380013206 phosphorylation site [posttranslational modification] 637380013207 DoxX; Region: DoxX; cl00976 637380013208 Flavin Reductases; Region: FlaRed; cl00801 637380013209 Domain of unknown function DUF; Region: DUF204; pfam02659 637380013210 Domain of unknown function DUF; Region: DUF204; pfam02659 637380013211 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 637380013212 SUA5 domain; Region: SUA5; pfam03481 637380013213 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 637380013214 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 637380013215 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 637380013216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380013217 S-adenosylmethionine binding site [chemical binding]; other site 637380013218 peptide chain release factor 1; Validated; Region: prfA; PRK00591 637380013219 RF-1 domain; Region: RF-1; cl02875 637380013220 RF-1 domain; Region: RF-1; cl02875 637380013221 Thymidine kinase; Region: TK; cl00631 637380013222 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 637380013223 transcription termination factor Rho; Provisional; Region: rho; PRK09376 637380013224 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 637380013225 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 637380013226 RNA binding site [nucleotide binding]; other site 637380013227 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 637380013228 multimer interface [polypeptide binding]; other site 637380013229 Walker A motif; other site 637380013230 ATP binding site [chemical binding]; other site 637380013231 Walker B motif; other site 637380013232 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins [Carbohydrate transport and metabolism]; Region: GlpX; COG1494 637380013233 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 637380013234 putative active site [active] 637380013235 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 637380013236 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 637380013237 hinge; other site 637380013238 active site 637380013239 hypothetical protein; Provisional; Region: PRK08185 637380013240 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 637380013241 intersubunit interface [polypeptide binding]; other site 637380013242 active site 637380013243 zinc binding site [ion binding]; other site 637380013244 Na+ binding site [ion binding]; other site 637380013245 Response regulator receiver domain; Region: Response_reg; pfam00072 637380013246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380013247 active site 637380013248 phosphorylation site [posttranslational modification] 637380013249 intermolecular recognition site; other site 637380013250 dimerization interface [polypeptide binding]; other site 637380013251 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 637380013252 CTP synthetase; Validated; Region: pyrG; PRK05380 637380013253 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 637380013254 Catalytic site [active] 637380013255 Active site [active] 637380013256 UTP binding site [chemical binding]; other site 637380013257 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 637380013258 active site 637380013259 putative oxyanion hole; other site 637380013260 catalytic triad [active] 637380013261 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 637380013262 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380013263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380013264 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 637380013265 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 637380013266 FAD binding site [chemical binding]; other site 637380013267 homotetramer interface [polypeptide binding]; other site 637380013268 substrate binding pocket [chemical binding]; other site 637380013269 catalytic base [active] 637380013270 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 637380013271 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 637380013272 FAD binding site [chemical binding]; other site 637380013273 homotetramer interface [polypeptide binding]; other site 637380013274 substrate binding pocket [chemical binding]; other site 637380013275 catalytic base [active] 637380013276 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 637380013277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380013278 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 637380013279 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 637380013280 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 637380013281 dimer interface [polypeptide binding]; other site 637380013282 active site 637380013283 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 637380013284 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 637380013285 Cysteine-rich domain; Region: CCG; pfam02754 637380013286 Cysteine-rich domain; Region: CCG; pfam02754 637380013287 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 637380013288 putative active site [active] 637380013289 catalytic site [active] 637380013290 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 637380013291 putative active site [active] 637380013292 catalytic site [active] 637380013293 UV-endonuclease UvdE; Region: UvdE; cl10036 637380013294 PAS domain S-box; Region: sensory_box; TIGR00229 637380013295 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637380013296 putative active site [active] 637380013297 heme pocket [chemical binding]; other site 637380013298 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637380013299 metal binding site [ion binding]; metal-binding site 637380013300 active site 637380013301 I-site; other site 637380013302 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637380013303 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 637380013304 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637380013305 non-specific DNA binding site [nucleotide binding]; other site 637380013306 salt bridge; other site 637380013307 sequence-specific DNA binding site [nucleotide binding]; other site 637380013308 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 637380013309 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637380013310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380013311 active site 637380013312 phosphorylation site [posttranslational modification] 637380013313 intermolecular recognition site; other site 637380013314 dimerization interface [polypeptide binding]; other site 637380013315 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 637380013316 DNA binding residues [nucleotide binding] 637380013317 dimerization interface [polypeptide binding]; other site 637380013318 Q-cell neuroblast polarisation; Region: Dpy19; pfam10034 637380013319 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 637380013320 Histidine kinase; Region: HisKA_3; pfam07730 637380013321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 637380013322 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 637380013323 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637380013324 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 637380013325 Walker A/P-loop; other site 637380013326 ATP binding site [chemical binding]; other site 637380013327 Q-loop/lid; other site 637380013328 ABC transporter signature motif; other site 637380013329 Walker B; other site 637380013330 D-loop; other site 637380013331 H-loop/switch region; other site 637380013332 methionine aminopeptidase; Reviewed; Region: PRK07281 637380013333 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 637380013334 active site 637380013335 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 637380013336 Collagen binding domain; Region: Collagen_bind; pfam05737 637380013337 Collagen binding domain; Region: Collagen_bind; pfam05737 637380013338 Collagen binding domain; Region: Collagen_bind; pfam05737 637380013339 Collagen binding domain; Region: Collagen_bind; pfam05737 637380013340 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380013341 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380013342 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380013343 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380013344 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380013345 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380013346 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380013347 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380013348 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380013349 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380013350 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380013351 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380013352 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380013353 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380013354 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380013355 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380013356 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380013357 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380013358 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380013359 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380013360 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380013361 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380013362 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 637380013363 M28, and M42; Region: Zinc_peptidase_like; cl14876 637380013364 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain...; Region: PA; cd00538 637380013365 PA/protease or protease-like domain interface [polypeptide binding]; other site 637380013366 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 637380013367 metal binding site [ion binding]; metal-binding site 637380013368 RNA polymerase sigma factor; Provisional; Region: PRK12522 637380013369 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637380013370 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 637380013371 DNA binding residues [nucleotide binding] 637380013372 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 637380013373 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 637380013374 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 637380013375 active site 637380013376 HIGH motif; other site 637380013377 KMSK motif region; other site 637380013378 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 637380013379 tRNA binding surface [nucleotide binding]; other site 637380013380 anticodon binding site; other site 637380013381 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 637380013382 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 637380013383 putative dimer interface [polypeptide binding]; other site 637380013384 catalytic triad [active] 637380013385 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 637380013386 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 637380013387 Arginase family; Region: Arginase; cl00306 637380013388 spermidine synthase; Provisional; Region: PRK00811 637380013389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 637380013390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380013391 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637380013392 putative substrate translocation pore; other site 637380013393 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 637380013394 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 637380013395 DNA binding residues [nucleotide binding] 637380013396 putative dimer interface [polypeptide binding]; other site 637380013397 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 637380013398 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 637380013399 active site 637380013400 catalytic site [active] 637380013401 metal binding site [ion binding]; metal-binding site 637380013402 dimer interface [polypeptide binding]; other site 637380013403 Transglycosylase; Region: Transgly; cl07896 637380013404 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 637380013405 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 637380013406 YwhD family; Region: YwhD; pfam08741 637380013407 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 637380013408 active site 637380013409 putative substrate binding region [chemical binding]; other site 637380013410 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 637380013411 active site 1 [active] 637380013412 dimer interface [polypeptide binding]; other site 637380013413 hexamer interface [polypeptide binding]; other site 637380013414 active site 2 [active] 637380013415 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 637380013416 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637380013417 Zn2+ binding site [ion binding]; other site 637380013418 Mg2+ binding site [ion binding]; other site 637380013419 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 637380013420 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 637380013421 intersubunit interface [polypeptide binding]; other site 637380013422 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 637380013423 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 637380013424 Walker A/P-loop; other site 637380013425 ATP binding site [chemical binding]; other site 637380013426 Q-loop/lid; other site 637380013427 ABC transporter signature motif; other site 637380013428 Walker B; other site 637380013429 D-loop; other site 637380013430 H-loop/switch region; other site 637380013431 ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605 637380013432 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 637380013433 ABC-ATPase subunit interface; other site 637380013434 dimer interface [polypeptide binding]; other site 637380013435 putative PBP binding regions; other site 637380013436 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 637380013437 ABC-ATPase subunit interface; other site 637380013438 dimer interface [polypeptide binding]; other site 637380013439 putative PBP binding regions; other site 637380013440 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 637380013441 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 637380013442 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 637380013443 hypothetical protein; Provisional; Region: PRK06760; cl11698 637380013444 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 637380013445 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 637380013446 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 637380013447 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 637380013448 Chlorite dismutase; Region: Chlor_dismutase; cl01280 637380013449 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 637380013450 Beta-lactamase; Region: Beta-lactamase; cl01009 637380013451 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 637380013452 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 637380013453 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881 637380013454 Protein of unknown function (DUF423); Region: DUF423; cl01008 637380013455 Ion channel; Region: Ion_trans_2; cl11596 637380013456 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 637380013457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380013458 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 637380013459 Permease family; Region: Xan_ur_permease; pfam00860 637380013460 Sulfate transporter family; Region: Sulfate_transp; cl00967 637380013461 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 637380013462 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637380013463 motif II; other site 637380013464 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 637380013465 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 637380013466 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 637380013467 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 637380013468 ABC-2 type transporter; Region: ABC2_membrane; cl11417 637380013469 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637380013470 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 637380013471 Walker A/P-loop; other site 637380013472 ATP binding site [chemical binding]; other site 637380013473 Q-loop/lid; other site 637380013474 ABC transporter signature motif; other site 637380013475 Walker B; other site 637380013476 D-loop; other site 637380013477 H-loop/switch region; other site 637380013478 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 637380013479 active site 637380013480 catalytic triad [active] 637380013481 oxyanion hole [active] 637380013482 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637380013483 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637380013484 DNA binding site [nucleotide binding] 637380013485 domain linker motif; other site 637380013486 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 637380013487 putative dimerization interface [polypeptide binding]; other site 637380013488 putative ligand binding site [chemical binding]; other site 637380013489 Predicted membrane protein [Function unknown]; Region: COG2364 637380013490 homoserine dehydrogenase; Provisional; Region: PRK06349 637380013491 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380013492 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 637380013493 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 637380013494 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 637380013495 proposed active site lysine [active] 637380013496 conserved cys residue [active] 637380013497 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 637380013498 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 637380013499 homodimer interface [polypeptide binding]; other site 637380013500 substrate-cofactor binding pocket; other site 637380013501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637380013502 catalytic residue [active] 637380013503 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 637380013504 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 637380013505 active site 637380013506 motif I; other site 637380013507 motif II; other site 637380013508 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 637380013509 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 637380013510 ligand binding site [chemical binding]; other site 637380013511 flexible hinge region; other site 637380013512 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 637380013513 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637380013514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380013515 active site 637380013516 phosphorylation site [posttranslational modification] 637380013517 intermolecular recognition site; other site 637380013518 dimerization interface [polypeptide binding]; other site 637380013519 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 637380013520 DNA binding residues [nucleotide binding] 637380013521 dimerization interface [polypeptide binding]; other site 637380013522 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 637380013523 GAF domain; Region: GAF; cl00853 637380013524 GAF domain; Region: GAF; cl00853 637380013525 Histidine kinase; Region: HisKA_3; pfam07730 637380013526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 637380013527 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 637380013528 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 637380013529 dimer interface [polypeptide binding]; other site 637380013530 substrate binding site [chemical binding]; other site 637380013531 ATP binding site [chemical binding]; other site 637380013532 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 637380013533 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637380013534 metal binding site [ion binding]; metal-binding site 637380013535 active site 637380013536 I-site; other site 637380013537 Protein of unknown function (DUF466); Region: DUF466; cl01082 637380013538 Carbon starvation protein CstA; Region: CstA; cl00856 637380013539 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 637380013540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380013541 active site 637380013542 phosphorylation site [posttranslational modification] 637380013543 intermolecular recognition site; other site 637380013544 dimerization interface [polypeptide binding]; other site 637380013545 LytTr DNA-binding domain; Region: LytTR; cl04498 637380013546 benzoate transport; Region: 2A0115; TIGR00895 637380013547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380013548 putative substrate translocation pore; other site 637380013549 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 637380013550 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 637380013551 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 637380013552 Predicted membrane protein [Function unknown]; Region: COG2860 637380013553 UPF0126 domain; Region: UPF0126; pfam03458 637380013554 UPF0126 domain; Region: UPF0126; pfam03458 637380013555 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are...; Region: sensor_globin; cd01068 637380013556 heme-binding site [chemical binding]; other site 637380013557 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 637380013558 conserved hypothetical integral membrane protein; Region: TIGR03766 637380013559 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 637380013560 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 637380013561 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 637380013562 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 637380013563 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 637380013564 active site 637380013565 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 637380013566 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637380013567 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637380013568 ABC transporter; Region: ABC_tran_2; pfam12848 637380013569 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 637380013570 conserved hypothetical integral membrane protein; Region: TIGR03766 637380013571 GtrA-like protein; Region: GtrA; cl00971 637380013572 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 637380013573 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 637380013574 Ligand binding site [chemical binding]; other site 637380013575 Putative Catalytic site [active] 637380013576 DXD motif; other site 637380013577 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637380013578 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637380013579 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 637380013580 Protein export membrane protein; Region: SecD_SecF; cl14618 637380013581 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 637380013582 SelR domain; Region: SelR; cl00369 637380013583 Domain of unknown function DUF20; Region: UPF0118; cl00465 637380013584 LrgB-like family; Region: LrgB; cl00596 637380013585 LrgA family; Region: LrgA; cl00608 637380013586 two-component response regulator; Provisional; Region: PRK14084 637380013587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380013588 active site 637380013589 phosphorylation site [posttranslational modification] 637380013590 intermolecular recognition site; other site 637380013591 dimerization interface [polypeptide binding]; other site 637380013592 LytTr DNA-binding domain; Region: LytTR; cl04498 637380013593 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 637380013594 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 637380013595 GAF domain; Region: GAF; cl00853 637380013596 Histidine kinase; Region: His_kinase; pfam06580 637380013597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380013598 ATP binding site [chemical binding]; other site 637380013599 Mg2+ binding site [ion binding]; other site 637380013600 G-X-G motif; other site 637380013601 benzoate transport; Region: 2A0115; TIGR00895 637380013602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637380013603 putative substrate translocation pore; other site 637380013604 BCCT family transporter; Region: BCCT; cl00569 637380013605 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(...; Region: NOS_oxygenase_prok; cd00794 637380013606 active site 637380013607 dimer interface [polypeptide binding]; other site 637380013608 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 637380013609 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 637380013610 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 637380013611 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 637380013612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637380013613 NAD(P) binding site [chemical binding]; other site 637380013614 active site 637380013615 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 637380013616 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 637380013617 UDP-glucose 4-epimerase; Region: PLN02240 637380013618 NAD binding site [chemical binding]; other site 637380013619 homodimer interface [polypeptide binding]; other site 637380013620 active site 637380013621 substrate binding site [chemical binding]; other site 637380013622 Haemolysin-III related; Region: HlyIII; cl03831 637380013623 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 637380013624 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 637380013625 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 637380013626 ATP binding site [chemical binding]; other site 637380013627 Mg++ binding site [ion binding]; other site 637380013628 motif III; other site 637380013629 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637380013630 nucleotide binding region [chemical binding]; other site 637380013631 ATP-binding site [chemical binding]; other site 637380013632 DbpA RNA binding domain; Region: DbpA; pfam03880 637380013633 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 637380013634 Acyltransferase family; Region: Acyl_transf_3; pfam01757 637380013635 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 637380013636 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 637380013637 active site 637380013638 oligoendopeptidase F; Region: pepF; TIGR00181 637380013639 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 637380013640 active site 637380013641 Zn binding site [ion binding]; other site 637380013642 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 637380013643 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 637380013644 FeS/SAM binding site; other site 637380013645 DNA helicase TIP49, TBP-interacting protein [Transcription]; Region: TIP49; COG1224 637380013646 NC domain; Region: NC; pfam04970 637380013647 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 637380013648 catalytic residues [active] 637380013649 catalytic nucleophile [active] 637380013650 Recombinase; Region: Recombinase; pfam07508 637380013651 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 637380013652 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 637380013653 P-loop; other site 637380013654 Magnesium ion binding site [ion binding]; other site 637380013655 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 637380013656 Magnesium ion binding site [ion binding]; other site 637380013657 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 637380013658 putative active site [active] 637380013659 putative NTP binding site [chemical binding]; other site 637380013660 putative nucleic acid binding site [nucleotide binding]; other site 637380013661 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 637380013662 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 637380013663 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 637380013664 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 637380013665 protein binding site [polypeptide binding]; other site 637380013666 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637380013667 YycH protein; Region: YycI; cl02015 637380013668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 637380013669 YycH protein; Region: YycH; pfam07435 637380013670 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 637380013671 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 637380013672 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 637380013673 dimerization interface [polypeptide binding]; other site 637380013674 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 637380013675 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 637380013676 dimer interface [polypeptide binding]; other site 637380013677 phosphorylation site [posttranslational modification] 637380013678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637380013679 ATP binding site [chemical binding]; other site 637380013680 Mg2+ binding site [ion binding]; other site 637380013681 G-X-G motif; other site 637380013682 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637380013683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 637380013684 active site 637380013685 phosphorylation site [posttranslational modification] 637380013686 intermolecular recognition site; other site 637380013687 dimerization interface [polypeptide binding]; other site 637380013688 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 637380013689 DNA binding site [nucleotide binding] 637380013690 adenylosuccinate synthetase; Provisional; Region: PRK01117 637380013691 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 637380013692 GDP-binding site [chemical binding]; other site 637380013693 ACT binding site; other site 637380013694 IMP binding site; other site 637380013695 replicative DNA helicase; Provisional; Region: PRK05748 637380013696 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 637380013697 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 637380013698 Walker A motif; other site 637380013699 ATP binding site [chemical binding]; other site 637380013700 Walker B motif; other site 637380013701 DNA binding loops [nucleotide binding] 637380013702 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 637380013703 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 637380013704 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 637380013705 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 637380013706 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 637380013707 DHH family; Region: DHH; pfam01368 637380013708 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 637380013709 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 637380013710 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 637380013711 dimer interface [polypeptide binding]; other site 637380013712 ssDNA binding site [nucleotide binding]; other site 637380013713 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637380013714 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 637380013715 GTP-binding protein YchF; Reviewed; Region: PRK09601 637380013716 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 637380013717 G1 box; other site 637380013718 GTP/Mg2+ binding site [chemical binding]; other site 637380013719 Switch I region; other site 637380013720 G2 box; other site 637380013721 Switch II region; other site 637380013722 G3 box; other site 637380013723 G4 box; other site 637380013724 G5 box; other site 637380013725 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 637380013726 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 637380013727 Mechanosensitive ion channel; Region: MS_channel; pfam00924 637380013728 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 637380013729 ParB-like partition proteins; Region: parB_part; TIGR00180 637380013730 ParB-like nuclease domain; Region: ParBc; cl02129 637380013731 KorB domain; Region: KorB; pfam08535 637380013732 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 637380013733 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 637380013734 P-loop; other site 637380013735 Magnesium ion binding site [ion binding]; other site 637380013736 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 637380013737 Magnesium ion binding site [ion binding]; other site 637380013738 ParB-like partition proteins; Region: parB_part; TIGR00180 637380013739 ParB-like nuclease domain; Region: ParBc; cl02129 637380013740 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 637380013741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 637380013742 S-adenosylmethionine binding site [chemical binding]; other site 637380013743 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 637380013744 glucose-inhibited division protein A; Region: gidA; TIGR00136 637380013745 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 637380013746 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 637380013747 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 637380013748 G1 box; other site 637380013749 GTP/Mg2+ binding site [chemical binding]; other site 637380013750 Switch I region; other site 637380013751 G2 box; other site 637380013752 Switch II region; other site 637380013753 G3 box; other site 637380013754 G4 box; other site 637380013755 G5 box; other site 637380013756 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 637380013757 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 637380013758 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 637380013759 G-X-X-G motif; other site 637380013760 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 637380013761 RxxxH motif; other site 637380013762 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 637380013763 Ribonuclease P; Region: Ribonuclease_P; cl00457 637380013764 Ribosomal protein L34; Region: Ribosomal_L34; cl00370