-- dump date 20140618_212430 -- class Genbank::misc_feature -- table misc_feature_note -- id note 260799000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 260799000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 260799000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799000004 Walker A motif; other site 260799000005 ATP binding site [chemical binding]; other site 260799000006 Walker B motif; other site 260799000007 arginine finger; other site 260799000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 260799000009 DnaA box-binding interface [nucleotide binding]; other site 260799000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 260799000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 260799000012 putative DNA binding surface [nucleotide binding]; other site 260799000013 dimer interface [polypeptide binding]; other site 260799000014 beta-clamp/clamp loader binding surface; other site 260799000015 beta-clamp/translesion DNA polymerase binding surface; other site 260799000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 260799000017 recombination protein F; Reviewed; Region: recF; PRK00064 260799000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 260799000019 Walker A/P-loop; other site 260799000020 ATP binding site [chemical binding]; other site 260799000021 Q-loop/lid; other site 260799000022 ABC transporter signature motif; other site 260799000023 Walker B; other site 260799000024 D-loop; other site 260799000025 H-loop/switch region; other site 260799000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 260799000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799000028 ATP binding site [chemical binding]; other site 260799000029 Mg2+ binding site [ion binding]; other site 260799000030 G-X-G motif; other site 260799000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 260799000032 anchoring element; other site 260799000033 dimer interface [polypeptide binding]; other site 260799000034 ATP binding site [chemical binding]; other site 260799000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 260799000036 active site 260799000037 putative metal-binding site [ion binding]; other site 260799000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 260799000039 DNA gyrase subunit A; Validated; Region: PRK05560 260799000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 260799000041 CAP-like domain; other site 260799000042 active site 260799000043 primary dimer interface [polypeptide binding]; other site 260799000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 260799000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 260799000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 260799000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 260799000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 260799000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 260799000050 YaaC-like Protein; Region: YaaC; pfam14175 260799000051 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 260799000052 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 260799000053 active site 260799000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 260799000055 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 260799000056 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 260799000057 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 260799000058 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 260799000059 active site 260799000060 multimer interface [polypeptide binding]; other site 260799000061 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 260799000062 predicted active site [active] 260799000063 catalytic triad [active] 260799000064 seryl-tRNA synthetase; Provisional; Region: PRK05431 260799000065 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 260799000066 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 260799000067 dimer interface [polypeptide binding]; other site 260799000068 active site 260799000069 motif 1; other site 260799000070 motif 2; other site 260799000071 motif 3; other site 260799000072 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 260799000073 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 260799000074 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 260799000075 DNA binding residues [nucleotide binding] 260799000076 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 260799000077 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 260799000078 Substrate-binding site [chemical binding]; other site 260799000079 Substrate specificity [chemical binding]; other site 260799000080 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 260799000081 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 260799000082 Substrate-binding site [chemical binding]; other site 260799000083 Substrate specificity [chemical binding]; other site 260799000084 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 260799000085 catalytic triad [active] 260799000086 conserved cis-peptide bond; other site 260799000087 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 260799000088 nucleoside/Zn binding site; other site 260799000089 dimer interface [polypeptide binding]; other site 260799000090 catalytic motif [active] 260799000091 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 260799000092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799000093 Walker A motif; other site 260799000094 ATP binding site [chemical binding]; other site 260799000095 Walker B motif; other site 260799000096 arginine finger; other site 260799000097 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 260799000098 hypothetical protein; Validated; Region: PRK00153 260799000099 recombination protein RecR; Reviewed; Region: recR; PRK00076 260799000100 Helix-hairpin-helix domain; Region: HHH_8; pfam14716 260799000101 RecR protein; Region: RecR; pfam02132 260799000102 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 260799000103 putative active site [active] 260799000104 putative metal-binding site [ion binding]; other site 260799000105 tetramer interface [polypeptide binding]; other site 260799000106 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 260799000107 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 260799000108 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 260799000109 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 260799000110 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 260799000111 homodimer interface [polypeptide binding]; other site 260799000112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799000113 catalytic residue [active] 260799000114 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 260799000115 thymidylate kinase; Validated; Region: tmk; PRK00698 260799000116 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 260799000117 TMP-binding site; other site 260799000118 ATP-binding site [chemical binding]; other site 260799000119 DNA polymerase III subunit delta'; Validated; Region: PRK08058 260799000120 DNA polymerase III subunit delta'; Validated; Region: PRK08485 260799000121 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 260799000122 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 260799000123 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 260799000124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799000125 S-adenosylmethionine binding site [chemical binding]; other site 260799000126 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 260799000127 GIY-YIG motif/motif A; other site 260799000128 putative active site [active] 260799000129 putative metal binding site [ion binding]; other site 260799000130 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 260799000131 putative SAM binding site [chemical binding]; other site 260799000132 putative homodimer interface [polypeptide binding]; other site 260799000133 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 260799000134 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 260799000135 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 260799000136 active site 260799000137 HIGH motif; other site 260799000138 KMSKS motif; other site 260799000139 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 260799000140 tRNA binding surface [nucleotide binding]; other site 260799000141 anticodon binding site; other site 260799000142 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 260799000143 dimer interface [polypeptide binding]; other site 260799000144 putative tRNA-binding site [nucleotide binding]; other site 260799000145 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 260799000146 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 260799000147 active site 260799000148 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 260799000149 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 260799000150 putative active site [active] 260799000151 putative metal binding site [ion binding]; other site 260799000152 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 260799000153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799000154 S-adenosylmethionine binding site [chemical binding]; other site 260799000155 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 260799000156 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 260799000157 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 260799000158 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 260799000159 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 260799000160 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 260799000161 pur operon repressor; Provisional; Region: PRK09213 260799000162 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 260799000163 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 260799000164 active site 260799000165 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 260799000166 homotrimer interaction site [polypeptide binding]; other site 260799000167 putative active site [active] 260799000168 regulatory protein SpoVG; Reviewed; Region: PRK13259 260799000169 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 260799000170 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 260799000171 Substrate binding site; other site 260799000172 Mg++ binding site; other site 260799000173 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 260799000174 active site 260799000175 substrate binding site [chemical binding]; other site 260799000176 CoA binding site [chemical binding]; other site 260799000177 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 260799000178 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 260799000179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 260799000180 active site 260799000181 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 260799000182 putative active site [active] 260799000183 catalytic residue [active] 260799000184 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 260799000185 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 260799000186 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 260799000187 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 260799000188 ATP binding site [chemical binding]; other site 260799000189 putative Mg++ binding site [ion binding]; other site 260799000190 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 260799000191 nucleotide binding region [chemical binding]; other site 260799000192 ATP-binding site [chemical binding]; other site 260799000193 TRCF domain; Region: TRCF; pfam03461 260799000194 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 260799000195 stage V sporulation protein T; Region: spore_V_T; TIGR02851 260799000196 stage V sporulation protein B; Region: spore_V_B; TIGR02900 260799000197 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 260799000198 Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; pfam14667 260799000199 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 260799000200 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 260799000201 putative SAM binding site [chemical binding]; other site 260799000202 putative homodimer interface [polypeptide binding]; other site 260799000203 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 260799000204 homodimer interface [polypeptide binding]; other site 260799000205 metal binding site [ion binding]; metal-binding site 260799000206 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 260799000207 homodimer interface [polypeptide binding]; other site 260799000208 active site 260799000209 putative chemical substrate binding site [chemical binding]; other site 260799000210 metal binding site [ion binding]; metal-binding site 260799000211 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 260799000212 RNA binding surface [nucleotide binding]; other site 260799000213 sporulation protein YabP; Region: spore_yabP; TIGR02892 260799000214 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 260799000215 Septum formation initiator; Region: DivIC; pfam04977 260799000216 hypothetical protein; Provisional; Region: PRK08582 260799000217 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 260799000218 RNA binding site [nucleotide binding]; other site 260799000219 stage II sporulation protein E; Region: spore_II_E; TIGR02865 260799000220 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 260799000221 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 260799000222 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 260799000223 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 260799000224 Ligand Binding Site [chemical binding]; other site 260799000225 TilS substrate binding domain; Region: TilS; pfam09179 260799000226 TilS substrate C-terminal domain; Region: TilS_C; smart00977 260799000227 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 260799000228 active site 260799000229 FtsH Extracellular; Region: FtsH_ext; pfam06480 260799000230 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 260799000231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799000232 Walker A motif; other site 260799000233 ATP binding site [chemical binding]; other site 260799000234 Walker B motif; other site 260799000235 arginine finger; other site 260799000236 Peptidase family M41; Region: Peptidase_M41; pfam01434 260799000237 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 260799000238 nucleotide binding site [chemical binding]; other site 260799000239 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 260799000240 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 260799000241 dimerization interface [polypeptide binding]; other site 260799000242 domain crossover interface; other site 260799000243 redox-dependent activation switch; other site 260799000244 cysteine synthase; Region: PLN02565 260799000245 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 260799000246 dimer interface [polypeptide binding]; other site 260799000247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799000248 catalytic residue [active] 260799000249 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 260799000250 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 260799000251 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 260799000252 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 260799000253 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 260799000254 glutamine binding [chemical binding]; other site 260799000255 catalytic triad [active] 260799000256 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 260799000257 homodimer interface [polypeptide binding]; other site 260799000258 substrate-cofactor binding pocket; other site 260799000259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799000260 catalytic residue [active] 260799000261 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 260799000262 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 260799000263 substrate binding pocket [chemical binding]; other site 260799000264 dimer interface [polypeptide binding]; other site 260799000265 inhibitor binding site; inhibition site 260799000266 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 260799000267 homooctamer interface [polypeptide binding]; other site 260799000268 active site 260799000269 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 260799000270 catalytic center binding site [active] 260799000271 ATP binding site [chemical binding]; other site 260799000272 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 260799000273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799000274 non-specific DNA binding site [nucleotide binding]; other site 260799000275 salt bridge; other site 260799000276 sequence-specific DNA binding site [nucleotide binding]; other site 260799000277 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 260799000278 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 260799000279 FMN binding site [chemical binding]; other site 260799000280 active site 260799000281 catalytic residues [active] 260799000282 substrate binding site [chemical binding]; other site 260799000283 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 260799000284 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 260799000285 dimer interface [polypeptide binding]; other site 260799000286 putative anticodon binding site; other site 260799000287 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 260799000288 motif 1; other site 260799000289 active site 260799000290 motif 2; other site 260799000291 motif 3; other site 260799000292 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 260799000293 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 260799000294 UvrB/uvrC motif; Region: UVR; pfam02151 260799000295 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 260799000296 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 260799000297 ADP binding site [chemical binding]; other site 260799000298 phosphagen binding site; other site 260799000299 substrate specificity loop; other site 260799000300 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 260799000301 Clp amino terminal domain; Region: Clp_N; pfam02861 260799000302 Clp amino terminal domain; Region: Clp_N; pfam02861 260799000303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799000304 Walker A motif; other site 260799000305 ATP binding site [chemical binding]; other site 260799000306 Walker B motif; other site 260799000307 arginine finger; other site 260799000308 UvrB/uvrC motif; Region: UVR; pfam02151 260799000309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799000310 Walker A motif; other site 260799000311 ATP binding site [chemical binding]; other site 260799000312 Walker B motif; other site 260799000313 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 260799000314 DNA repair protein RadA; Provisional; Region: PRK11823 260799000315 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 260799000316 Walker A motif/ATP binding site; other site 260799000317 ATP binding site [chemical binding]; other site 260799000318 Walker B motif; other site 260799000319 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 260799000320 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 260799000321 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 260799000322 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 260799000323 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 260799000324 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 260799000325 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 260799000326 putative active site [active] 260799000327 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 260799000328 substrate binding site; other site 260799000329 dimer interface; other site 260799000330 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 260799000331 homotrimer interaction site [polypeptide binding]; other site 260799000332 zinc binding site [ion binding]; other site 260799000333 CDP-binding sites; other site 260799000334 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 260799000335 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 260799000336 active site 260799000337 HIGH motif; other site 260799000338 KMSKS motif; other site 260799000339 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 260799000340 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 260799000341 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 260799000342 trimer interface [polypeptide binding]; other site 260799000343 active site 260799000344 substrate binding site [chemical binding]; other site 260799000345 CoA binding site [chemical binding]; other site 260799000346 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 260799000347 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 260799000348 active site 260799000349 HIGH motif; other site 260799000350 KMSKS motif; other site 260799000351 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 260799000352 tRNA binding surface [nucleotide binding]; other site 260799000353 anticodon binding site; other site 260799000354 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 260799000355 active site 260799000356 metal binding site [ion binding]; metal-binding site 260799000357 dimerization interface [polypeptide binding]; other site 260799000358 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 260799000359 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 260799000360 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 260799000361 YacP-like NYN domain; Region: NYN_YacP; pfam05991 260799000362 RNA polymerase factor sigma-70; Validated; Region: PRK08295 260799000363 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799000364 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 260799000365 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 260799000366 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 260799000367 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 260799000368 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 260799000369 putative homodimer interface [polypeptide binding]; other site 260799000370 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 260799000371 heterodimer interface [polypeptide binding]; other site 260799000372 homodimer interface [polypeptide binding]; other site 260799000373 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 260799000374 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 260799000375 23S rRNA interface [nucleotide binding]; other site 260799000376 L7/L12 interface [polypeptide binding]; other site 260799000377 putative thiostrepton binding site; other site 260799000378 L25 interface [polypeptide binding]; other site 260799000379 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 260799000380 mRNA/rRNA interface [nucleotide binding]; other site 260799000381 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 260799000382 23S rRNA interface [nucleotide binding]; other site 260799000383 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 260799000384 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 260799000385 core dimer interface [polypeptide binding]; other site 260799000386 peripheral dimer interface [polypeptide binding]; other site 260799000387 L10 interface [polypeptide binding]; other site 260799000388 L11 interface [polypeptide binding]; other site 260799000389 putative EF-Tu interaction site [polypeptide binding]; other site 260799000390 putative EF-G interaction site [polypeptide binding]; other site 260799000391 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 260799000392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799000393 S-adenosylmethionine binding site [chemical binding]; other site 260799000394 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 260799000395 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 260799000396 RPB12 interaction site [polypeptide binding]; other site 260799000397 RPB1 interaction site [polypeptide binding]; other site 260799000398 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 260799000399 RPB10 interaction site [polypeptide binding]; other site 260799000400 RPB11 interaction site [polypeptide binding]; other site 260799000401 RPB3 interaction site [polypeptide binding]; other site 260799000402 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 260799000403 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 260799000404 beta and beta' interface [polypeptide binding]; other site 260799000405 beta' and sigma factor interface [polypeptide binding]; other site 260799000406 Zn-binding [ion binding]; other site 260799000407 active site region [active] 260799000408 catalytic site [active] 260799000409 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 260799000410 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 260799000411 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 260799000412 G-loop; other site 260799000413 DNA binding site [nucleotide binding] 260799000414 hypothetical protein; Provisional; Region: PRK06683 260799000415 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 260799000416 S17 interaction site [polypeptide binding]; other site 260799000417 S8 interaction site; other site 260799000418 16S rRNA interaction site [nucleotide binding]; other site 260799000419 streptomycin interaction site [chemical binding]; other site 260799000420 23S rRNA interaction site [nucleotide binding]; other site 260799000421 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 260799000422 30S ribosomal protein S7; Validated; Region: PRK05302 260799000423 elongation factor G; Reviewed; Region: PRK00007 260799000424 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 260799000425 G1 box; other site 260799000426 putative GEF interaction site [polypeptide binding]; other site 260799000427 GTP/Mg2+ binding site [chemical binding]; other site 260799000428 Switch I region; other site 260799000429 G2 box; other site 260799000430 G3 box; other site 260799000431 Switch II region; other site 260799000432 G4 box; other site 260799000433 G5 box; other site 260799000434 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 260799000435 Elongation Factor G, domain II; Region: EFG_II; pfam14492 260799000436 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 260799000437 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 260799000438 elongation factor Tu; Reviewed; Region: PRK00049 260799000439 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 260799000440 G1 box; other site 260799000441 GEF interaction site [polypeptide binding]; other site 260799000442 GTP/Mg2+ binding site [chemical binding]; other site 260799000443 Switch I region; other site 260799000444 G2 box; other site 260799000445 G3 box; other site 260799000446 Switch II region; other site 260799000447 G4 box; other site 260799000448 G5 box; other site 260799000449 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 260799000450 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 260799000451 Antibiotic Binding Site [chemical binding]; other site 260799000452 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 260799000453 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 260799000454 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 260799000455 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 260799000456 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 260799000457 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 260799000458 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 260799000459 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 260799000460 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 260799000461 putative translocon binding site; other site 260799000462 protein-rRNA interface [nucleotide binding]; other site 260799000463 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 260799000464 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 260799000465 G-X-X-G motif; other site 260799000466 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 260799000467 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 260799000468 23S rRNA interface [nucleotide binding]; other site 260799000469 5S rRNA interface [nucleotide binding]; other site 260799000470 putative antibiotic binding site [chemical binding]; other site 260799000471 L25 interface [polypeptide binding]; other site 260799000472 L27 interface [polypeptide binding]; other site 260799000473 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 260799000474 23S rRNA interface [nucleotide binding]; other site 260799000475 putative translocon interaction site; other site 260799000476 signal recognition particle (SRP54) interaction site; other site 260799000477 L23 interface [polypeptide binding]; other site 260799000478 trigger factor interaction site; other site 260799000479 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 260799000480 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 260799000481 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 260799000482 RNA binding site [nucleotide binding]; other site 260799000483 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 260799000484 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 260799000485 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 260799000486 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 260799000487 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 260799000488 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 260799000489 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 260799000490 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 260799000491 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 260799000492 5S rRNA interface [nucleotide binding]; other site 260799000493 L27 interface [polypeptide binding]; other site 260799000494 23S rRNA interface [nucleotide binding]; other site 260799000495 L5 interface [polypeptide binding]; other site 260799000496 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 260799000497 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 260799000498 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 260799000499 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 260799000500 23S rRNA binding site [nucleotide binding]; other site 260799000501 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 260799000502 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 260799000503 SecY translocase; Region: SecY; pfam00344 260799000504 adenylate kinase; Reviewed; Region: adk; PRK00279 260799000505 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 260799000506 AMP-binding site [chemical binding]; other site 260799000507 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 260799000508 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 260799000509 active site 260799000510 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 260799000511 rRNA binding site [nucleotide binding]; other site 260799000512 predicted 30S ribosome binding site; other site 260799000513 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 260799000514 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 260799000515 30S ribosomal protein S11; Validated; Region: PRK05309 260799000516 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 260799000517 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 260799000518 alphaNTD - beta interaction site [polypeptide binding]; other site 260799000519 alphaNTD homodimer interface [polypeptide binding]; other site 260799000520 alphaNTD - beta' interaction site [polypeptide binding]; other site 260799000521 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 260799000522 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 260799000523 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 260799000524 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 260799000525 Walker A/P-loop; other site 260799000526 ATP binding site [chemical binding]; other site 260799000527 Q-loop/lid; other site 260799000528 ABC transporter signature motif; other site 260799000529 Walker B; other site 260799000530 D-loop; other site 260799000531 H-loop/switch region; other site 260799000532 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 260799000533 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 260799000534 Walker A/P-loop; other site 260799000535 ATP binding site [chemical binding]; other site 260799000536 Q-loop/lid; other site 260799000537 ABC transporter signature motif; other site 260799000538 Walker B; other site 260799000539 D-loop; other site 260799000540 H-loop/switch region; other site 260799000541 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 260799000542 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 260799000543 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 260799000544 dimerization interface 3.5A [polypeptide binding]; other site 260799000545 active site 260799000546 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 260799000547 23S rRNA interface [nucleotide binding]; other site 260799000548 L3 interface [polypeptide binding]; other site 260799000549 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 260799000550 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 260799000551 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 260799000552 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 260799000553 active site 260799000554 metal binding site [ion binding]; metal-binding site 260799000555 Domain of unknown function DUF59; Region: DUF59; cl00941 260799000556 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 260799000557 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 260799000558 Walker A motif; other site 260799000559 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 260799000560 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 260799000561 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 260799000562 NodB motif; other site 260799000563 putative active site [active] 260799000564 putative catalytic site [active] 260799000565 Arginase family; Region: Arginase; cd09989 260799000566 active site 260799000567 Mn binding site [ion binding]; other site 260799000568 oligomer interface [polypeptide binding]; other site 260799000569 Uncharacterized conserved protein [Function unknown]; Region: COG1624 260799000570 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 260799000571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 260799000572 YbbR-like protein; Region: YbbR; pfam07949 260799000573 YbbR-like protein; Region: YbbR; pfam07949 260799000574 YbbR-like protein; Region: YbbR; pfam07949 260799000575 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 260799000576 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 260799000577 active site 260799000578 substrate binding site [chemical binding]; other site 260799000579 metal binding site [ion binding]; metal-binding site 260799000580 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 260799000581 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 260799000582 glutaminase active site [active] 260799000583 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 260799000584 dimer interface [polypeptide binding]; other site 260799000585 active site 260799000586 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 260799000587 dimer interface [polypeptide binding]; other site 260799000588 active site 260799000589 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799000590 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 260799000591 Transcriptional regulators [Transcription]; Region: GntR; COG1802 260799000592 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 260799000593 DNA-binding site [nucleotide binding]; DNA binding site 260799000594 FCD domain; Region: FCD; pfam07729 260799000595 gluconate transporter; Region: gntP; TIGR00791 260799000596 GntP family permease; Region: GntP_permease; pfam02447 260799000597 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 260799000598 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 260799000599 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 260799000600 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 260799000601 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 260799000602 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 260799000603 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 260799000604 Predicted membrane protein [Function unknown]; Region: COG2259 260799000605 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 260799000606 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 260799000607 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 260799000608 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799000609 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 260799000610 DNA binding residues [nucleotide binding] 260799000611 ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Region: ectoine_ehuD; TIGR03003 260799000612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799000613 dimer interface [polypeptide binding]; other site 260799000614 conserved gate region; other site 260799000615 putative PBP binding loops; other site 260799000616 ABC-ATPase subunit interface; other site 260799000617 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 260799000618 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 260799000619 Walker A/P-loop; other site 260799000620 ATP binding site [chemical binding]; other site 260799000621 Q-loop/lid; other site 260799000622 ABC transporter signature motif; other site 260799000623 Walker B; other site 260799000624 D-loop; other site 260799000625 H-loop/switch region; other site 260799000626 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 260799000627 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 260799000628 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 260799000629 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 260799000630 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 260799000631 putative NAD(P) binding site [chemical binding]; other site 260799000632 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 260799000633 FAD binding domain; Region: FAD_binding_4; pfam01565 260799000634 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 260799000635 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799000636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799000637 putative substrate translocation pore; other site 260799000638 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 260799000639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799000640 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 260799000641 putative substrate translocation pore; other site 260799000642 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 260799000643 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 260799000644 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 260799000645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799000646 dimer interface [polypeptide binding]; other site 260799000647 conserved gate region; other site 260799000648 putative PBP binding loops; other site 260799000649 ABC-ATPase subunit interface; other site 260799000650 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 260799000651 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 260799000652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799000653 dimer interface [polypeptide binding]; other site 260799000654 conserved gate region; other site 260799000655 putative PBP binding loops; other site 260799000656 ABC-ATPase subunit interface; other site 260799000657 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 260799000658 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 260799000659 Walker A/P-loop; other site 260799000660 ATP binding site [chemical binding]; other site 260799000661 Q-loop/lid; other site 260799000662 ABC transporter signature motif; other site 260799000663 Walker B; other site 260799000664 D-loop; other site 260799000665 H-loop/switch region; other site 260799000666 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 260799000667 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 260799000668 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 260799000669 Walker A/P-loop; other site 260799000670 ATP binding site [chemical binding]; other site 260799000671 Q-loop/lid; other site 260799000672 ABC transporter signature motif; other site 260799000673 Walker B; other site 260799000674 D-loop; other site 260799000675 H-loop/switch region; other site 260799000676 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 260799000677 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 260799000678 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 260799000679 peptide binding site [polypeptide binding]; other site 260799000680 YusW-like protein; Region: YusW; pfam14039 260799000681 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 260799000682 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 260799000683 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 260799000684 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 260799000685 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 260799000686 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 260799000687 peptide binding site [polypeptide binding]; other site 260799000688 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 260799000689 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 260799000690 peptide binding site [polypeptide binding]; other site 260799000691 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 260799000692 active site 260799000693 catalytic tetrad [active] 260799000694 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 260799000695 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 260799000696 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 260799000697 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 260799000698 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 260799000699 Sugar transport protein; Region: Sugar_transport; pfam06800 260799000700 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 260799000701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799000702 dimer interface [polypeptide binding]; other site 260799000703 conserved gate region; other site 260799000704 putative PBP binding loops; other site 260799000705 ABC-ATPase subunit interface; other site 260799000706 DNA binding domain, excisionase family; Region: excise; TIGR01764 260799000707 PBP superfamily domain; Region: PBP_like; pfam12727 260799000708 Transcriptional regulator [Transcription]; Region: LysR; COG0583 260799000709 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 260799000710 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 260799000711 putative dimerization interface [polypeptide binding]; other site 260799000712 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 260799000713 EamA-like transporter family; Region: EamA; pfam00892 260799000714 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 260799000715 putative acyl-acceptor binding pocket; other site 260799000716 Transcriptional regulators [Transcription]; Region: PurR; COG1609 260799000717 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 260799000718 DNA binding site [nucleotide binding] 260799000719 domain linker motif; other site 260799000720 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 260799000721 putative ligand binding site [chemical binding]; other site 260799000722 putative dimerization interface [polypeptide binding]; other site 260799000723 Bacterial PH domain; Region: bPH_3; pfam14470 260799000724 Uncharacterized conserved protein [Function unknown]; Region: COG1284 260799000725 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 260799000726 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 260799000727 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 260799000728 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 260799000729 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 260799000730 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 260799000731 active site 260799000732 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 260799000733 NodB motif; other site 260799000734 putative active site [active] 260799000735 putative catalytic site [active] 260799000736 putative Zn binding site [ion binding]; other site 260799000737 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 260799000738 C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441 260799000739 lysozyme catalytic site [active] 260799000740 catalytic residue [active] 260799000741 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 260799000742 nucleotide binding site/active site [active] 260799000743 HIT family signature motif; other site 260799000744 catalytic residue [active] 260799000745 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 260799000746 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 260799000747 ABC transporter; Region: ABC_tran_2; pfam12848 260799000748 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 260799000749 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 260799000750 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 260799000751 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 260799000752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799000753 dimer interface [polypeptide binding]; other site 260799000754 conserved gate region; other site 260799000755 putative PBP binding loops; other site 260799000756 ABC-ATPase subunit interface; other site 260799000757 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 260799000758 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 260799000759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799000760 dimer interface [polypeptide binding]; other site 260799000761 conserved gate region; other site 260799000762 putative PBP binding loops; other site 260799000763 ABC-ATPase subunit interface; other site 260799000764 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 260799000765 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 260799000766 Walker A/P-loop; other site 260799000767 ATP binding site [chemical binding]; other site 260799000768 Q-loop/lid; other site 260799000769 ABC transporter signature motif; other site 260799000770 Walker B; other site 260799000771 D-loop; other site 260799000772 H-loop/switch region; other site 260799000773 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 260799000774 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 260799000775 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 260799000776 Walker A/P-loop; other site 260799000777 ATP binding site [chemical binding]; other site 260799000778 Q-loop/lid; other site 260799000779 ABC transporter signature motif; other site 260799000780 Walker B; other site 260799000781 D-loop; other site 260799000782 H-loop/switch region; other site 260799000783 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 260799000784 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 260799000785 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 260799000786 dimer interface [polypeptide binding]; other site 260799000787 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 260799000788 active site 260799000789 Fe binding site [ion binding]; other site 260799000790 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 260799000791 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 260799000792 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 260799000793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799000794 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799000795 putative substrate translocation pore; other site 260799000796 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 260799000797 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 260799000798 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 260799000799 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 260799000800 helicase 45; Provisional; Region: PTZ00424 260799000801 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 260799000802 ATP binding site [chemical binding]; other site 260799000803 Mg++ binding site [ion binding]; other site 260799000804 motif III; other site 260799000805 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 260799000806 nucleotide binding region [chemical binding]; other site 260799000807 ATP-binding site [chemical binding]; other site 260799000808 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 260799000809 Rhomboid family; Region: Rhomboid; pfam01694 260799000810 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 260799000811 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 260799000812 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 260799000813 alanine racemase; Reviewed; Region: alr; PRK00053 260799000814 active site 260799000815 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 260799000816 dimer interface [polypeptide binding]; other site 260799000817 substrate binding site [chemical binding]; other site 260799000818 catalytic residues [active] 260799000819 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 260799000820 PemK-like protein; Region: PemK; pfam02452 260799000821 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 260799000822 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 260799000823 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 260799000824 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 260799000825 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 260799000826 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 260799000827 RNA binding site [nucleotide binding]; other site 260799000828 hypothetical protein; Provisional; Region: PRK04351 260799000829 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 260799000830 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 260799000831 Glycoprotease family; Region: Peptidase_M22; pfam00814 260799000832 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 260799000833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799000834 Coenzyme A binding pocket [chemical binding]; other site 260799000835 UGMP family protein; Validated; Region: PRK09604 260799000836 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 260799000837 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 260799000838 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 260799000839 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 260799000840 ABC transporter; Region: ABC_tran_2; pfam12848 260799000841 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 260799000842 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 260799000843 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 260799000844 CoA binding domain; Region: CoA_binding; pfam02629 260799000845 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 260799000846 CAAX protease self-immunity; Region: Abi; pfam02517 260799000847 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 260799000848 oligomerisation interface [polypeptide binding]; other site 260799000849 mobile loop; other site 260799000850 roof hairpin; other site 260799000851 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 260799000852 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 260799000853 ring oligomerisation interface [polypeptide binding]; other site 260799000854 ATP/Mg binding site [chemical binding]; other site 260799000855 stacking interactions; other site 260799000856 hinge regions; other site 260799000857 GMP synthase; Reviewed; Region: guaA; PRK00074 260799000858 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 260799000859 AMP/PPi binding site [chemical binding]; other site 260799000860 candidate oxyanion hole; other site 260799000861 catalytic triad [active] 260799000862 potential glutamine specificity residues [chemical binding]; other site 260799000863 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 260799000864 ATP Binding subdomain [chemical binding]; other site 260799000865 Ligand Binding sites [chemical binding]; other site 260799000866 Dimerization subdomain; other site 260799000867 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 260799000868 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799000869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799000870 active site 260799000871 phosphorylation site [posttranslational modification] 260799000872 intermolecular recognition site; other site 260799000873 dimerization interface [polypeptide binding]; other site 260799000874 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799000875 DNA binding site [nucleotide binding] 260799000876 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799000877 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799000878 dimerization interface [polypeptide binding]; other site 260799000879 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799000880 dimer interface [polypeptide binding]; other site 260799000881 phosphorylation site [posttranslational modification] 260799000882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799000883 ATP binding site [chemical binding]; other site 260799000884 Mg2+ binding site [ion binding]; other site 260799000885 G-X-G motif; other site 260799000886 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 260799000887 putative ligand binding site [chemical binding]; other site 260799000888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799000889 S-adenosylmethionine binding site [chemical binding]; other site 260799000890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799000891 S-adenosylmethionine binding site [chemical binding]; other site 260799000892 Sulfotransferase family; Region: Sulfotransfer_2; cl19526 260799000893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799000894 S-adenosylmethionine binding site [chemical binding]; other site 260799000895 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 260799000896 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 260799000897 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 260799000898 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 260799000899 active site 260799000900 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 260799000901 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 260799000902 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 260799000903 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 260799000904 Walker A/P-loop; other site 260799000905 ATP binding site [chemical binding]; other site 260799000906 Q-loop/lid; other site 260799000907 ABC transporter signature motif; other site 260799000908 Walker B; other site 260799000909 D-loop; other site 260799000910 H-loop/switch region; other site 260799000911 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799000912 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799000913 dimer interface [polypeptide binding]; other site 260799000914 phosphorylation site [posttranslational modification] 260799000915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799000916 ATP binding site [chemical binding]; other site 260799000917 Mg2+ binding site [ion binding]; other site 260799000918 G-X-G motif; other site 260799000919 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799000920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799000921 active site 260799000922 phosphorylation site [posttranslational modification] 260799000923 intermolecular recognition site; other site 260799000924 dimerization interface [polypeptide binding]; other site 260799000925 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799000926 DNA binding site [nucleotide binding] 260799000927 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 260799000928 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 260799000929 ATP-grasp domain; Region: ATP-grasp; pfam02222 260799000930 adenylosuccinate lyase; Provisional; Region: PRK07492 260799000931 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 260799000932 tetramer interface [polypeptide binding]; other site 260799000933 active site 260799000934 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 260799000935 ATP binding site [chemical binding]; other site 260799000936 active site 260799000937 substrate binding site [chemical binding]; other site 260799000938 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 260799000939 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 260799000940 putative active site [active] 260799000941 catalytic triad [active] 260799000942 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 260799000943 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 260799000944 dimerization interface [polypeptide binding]; other site 260799000945 ATP binding site [chemical binding]; other site 260799000946 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 260799000947 dimerization interface [polypeptide binding]; other site 260799000948 ATP binding site [chemical binding]; other site 260799000949 amidophosphoribosyltransferase; Provisional; Region: PRK06781 260799000950 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 260799000951 active site 260799000952 tetramer interface [polypeptide binding]; other site 260799000953 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 260799000954 active site 260799000955 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 260799000956 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 260799000957 dimerization interface [polypeptide binding]; other site 260799000958 putative ATP binding site [chemical binding]; other site 260799000959 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 260799000960 active site 260799000961 substrate binding site [chemical binding]; other site 260799000962 cosubstrate binding site; other site 260799000963 catalytic site [active] 260799000964 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 260799000965 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 260799000966 purine monophosphate binding site [chemical binding]; other site 260799000967 dimer interface [polypeptide binding]; other site 260799000968 putative catalytic residues [active] 260799000969 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 260799000970 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 260799000971 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 260799000972 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 260799000973 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 260799000974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 260799000975 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u2; cd03402 260799000976 prohibitin homologues; Region: PHB; smart00244 260799000977 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 260799000978 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 260799000979 substrate binding site [chemical binding]; other site 260799000980 putative active site [active] 260799000981 dimer interface [polypeptide binding]; other site 260799000982 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 260799000983 Part of AAA domain; Region: AAA_19; pfam13245 260799000984 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 260799000985 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 260799000986 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 260799000987 nucleotide binding pocket [chemical binding]; other site 260799000988 K-X-D-G motif; other site 260799000989 catalytic site [active] 260799000990 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 260799000991 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 260799000992 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 260799000993 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 260799000994 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 260799000995 Dimer interface [polypeptide binding]; other site 260799000996 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 260799000997 putative dimer interface [polypeptide binding]; other site 260799000998 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 260799000999 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 260799001000 putative dimer interface [polypeptide binding]; other site 260799001001 hypothetical protein; Provisional; Region: PRK10621 260799001002 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 260799001003 Glutamate binding site [chemical binding]; other site 260799001004 homodimer interface [polypeptide binding]; other site 260799001005 NAD binding site [chemical binding]; other site 260799001006 catalytic residues [active] 260799001007 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 260799001008 catalytic triad [active] 260799001009 conserved cis-peptide bond; other site 260799001010 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 260799001011 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 260799001012 Walker A/P-loop; other site 260799001013 ATP binding site [chemical binding]; other site 260799001014 Q-loop/lid; other site 260799001015 ABC transporter signature motif; other site 260799001016 Walker B; other site 260799001017 D-loop; other site 260799001018 H-loop/switch region; other site 260799001019 NIL domain; Region: NIL; pfam09383 260799001020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799001021 dimer interface [polypeptide binding]; other site 260799001022 conserved gate region; other site 260799001023 putative PBP binding loops; other site 260799001024 ABC-ATPase subunit interface; other site 260799001025 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 260799001026 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 260799001027 Protein of unknown function (DUF3926); Region: DUF3926; pfam13080 260799001028 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 260799001029 Transcriptional regulators [Transcription]; Region: MarR; COG1846 260799001030 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 260799001031 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 260799001032 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 260799001033 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 260799001034 GatB domain; Region: GatB_Yqey; pfam02637 260799001035 putative lipid kinase; Reviewed; Region: PRK13337 260799001036 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 260799001037 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 260799001038 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 260799001039 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799001040 motif II; other site 260799001041 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 260799001042 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 260799001043 inhibitor-cofactor binding pocket; inhibition site 260799001044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799001045 catalytic residue [active] 260799001046 PAS domain; Region: PAS_9; pfam13426 260799001047 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 260799001048 putative active site [active] 260799001049 heme pocket [chemical binding]; other site 260799001050 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 260799001051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799001052 Walker A motif; other site 260799001053 ATP binding site [chemical binding]; other site 260799001054 Walker B motif; other site 260799001055 arginine finger; other site 260799001056 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 260799001057 tetramerization interface [polypeptide binding]; other site 260799001058 NAD(P) binding site [chemical binding]; other site 260799001059 catalytic residues [active] 260799001060 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 260799001061 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 260799001062 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 260799001063 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 260799001064 putative active site [active] 260799001065 putative metal binding site [ion binding]; other site 260799001066 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 260799001067 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 260799001068 putative active site [active] 260799001069 putative metal binding site [ion binding]; other site 260799001070 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 260799001071 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 260799001072 Nucleoside recognition; Region: Gate; pfam07670 260799001073 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 260799001074 TRAM domain; Region: TRAM; cl01282 260799001075 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 260799001076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799001077 S-adenosylmethionine binding site [chemical binding]; other site 260799001078 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 260799001079 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 260799001080 FMN binding site [chemical binding]; other site 260799001081 active site 260799001082 catalytic residues [active] 260799001083 substrate binding site [chemical binding]; other site 260799001084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 260799001085 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 260799001086 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 260799001087 Protein of unknown function DUF45; Region: DUF45; pfam01863 260799001088 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 260799001089 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 260799001090 active site 260799001091 Predicted transcriptional regulator [Transcription]; Region: COG3355 260799001092 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 260799001093 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 260799001094 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 260799001095 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 260799001096 amidohydrolase; Region: amidohydrolases; TIGR01891 260799001097 metal binding site [ion binding]; metal-binding site 260799001098 putative dimer interface [polypeptide binding]; other site 260799001099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799001100 S-adenosylmethionine binding site [chemical binding]; other site 260799001101 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 260799001102 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 260799001103 catalytic residue [active] 260799001104 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 260799001105 catalytic residues [active] 260799001106 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 260799001107 peroxiredoxin; Region: AhpC; TIGR03137 260799001108 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 260799001109 dimer interface [polypeptide binding]; other site 260799001110 decamer (pentamer of dimers) interface [polypeptide binding]; other site 260799001111 catalytic triad [active] 260799001112 peroxidatic and resolving cysteines [active] 260799001113 5-methylribose kinase; Reviewed; Region: PRK12396 260799001114 Phosphotransferase enzyme family; Region: APH; pfam01636 260799001115 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 260799001116 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 260799001117 intersubunit interface [polypeptide binding]; other site 260799001118 active site 260799001119 Zn2+ binding site [ion binding]; other site 260799001120 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 260799001121 ABC-ATPase subunit interface; other site 260799001122 dimer interface [polypeptide binding]; other site 260799001123 putative PBP binding regions; other site 260799001124 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 260799001125 ABC-ATPase subunit interface; other site 260799001126 dimer interface [polypeptide binding]; other site 260799001127 putative PBP binding regions; other site 260799001128 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 260799001129 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 260799001130 putative ligand binding residues [chemical binding]; other site 260799001131 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 260799001132 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 260799001133 DNA binding domain, excisionase family; Region: excise; TIGR01764 260799001134 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 260799001135 Sm and related proteins; Region: Sm_like; cl00259 260799001136 Sm1 motif; other site 260799001137 RNA binding site [nucleotide binding]; other site 260799001138 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 260799001139 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 260799001140 hypothetical protein; Provisional; Region: PRK06851 260799001141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799001142 Walker A motif; other site 260799001143 ATP binding site [chemical binding]; other site 260799001144 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 260799001145 G1 box; other site 260799001146 GTP/Mg2+ binding site [chemical binding]; other site 260799001147 G2 box; other site 260799001148 Switch I region; other site 260799001149 G3 box; other site 260799001150 Switch II region; other site 260799001151 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 260799001152 benzoate transport; Region: 2A0115; TIGR00895 260799001153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799001154 putative substrate translocation pore; other site 260799001155 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 260799001156 FAD dependent oxidoreductase; Region: DAO; pfam01266 260799001157 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 260799001158 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 260799001159 [2Fe-2S] cluster binding site [ion binding]; other site 260799001160 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 260799001161 putative di-iron ligands [ion binding]; other site 260799001162 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 260799001163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799001164 dimer interface [polypeptide binding]; other site 260799001165 conserved gate region; other site 260799001166 putative PBP binding loops; other site 260799001167 ABC-ATPase subunit interface; other site 260799001168 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 260799001169 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 260799001170 substrate binding pocket [chemical binding]; other site 260799001171 membrane-bound complex binding site; other site 260799001172 hinge residues; other site 260799001173 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 260799001174 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 260799001175 Walker A/P-loop; other site 260799001176 ATP binding site [chemical binding]; other site 260799001177 Q-loop/lid; other site 260799001178 ABC transporter signature motif; other site 260799001179 Walker B; other site 260799001180 D-loop; other site 260799001181 H-loop/switch region; other site 260799001182 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 260799001183 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799001184 dimerization interface [polypeptide binding]; other site 260799001185 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 260799001186 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 260799001187 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 260799001188 dimer interface [polypeptide binding]; other site 260799001189 putative CheW interface [polypeptide binding]; other site 260799001190 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 260799001191 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799001192 dimerization interface [polypeptide binding]; other site 260799001193 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 260799001194 dimer interface [polypeptide binding]; other site 260799001195 putative CheW interface [polypeptide binding]; other site 260799001196 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 260799001197 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 260799001198 Ca binding site [ion binding]; other site 260799001199 active site 260799001200 catalytic site [active] 260799001201 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 260799001202 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 260799001203 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 260799001204 active site turn [active] 260799001205 phosphorylation site [posttranslational modification] 260799001206 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 260799001207 putative catalytic site [active] 260799001208 putative metal binding site [ion binding]; other site 260799001209 putative phosphate binding site [ion binding]; other site 260799001210 Predicted membrane protein [Function unknown]; Region: COG1511 260799001211 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 260799001212 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 260799001213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799001214 DNA topoisomerase III; Provisional; Region: PRK07726 260799001215 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 260799001216 active site 260799001217 putative interdomain interaction site [polypeptide binding]; other site 260799001218 putative metal-binding site [ion binding]; other site 260799001219 putative nucleotide binding site [chemical binding]; other site 260799001220 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 260799001221 domain I; other site 260799001222 DNA binding groove [nucleotide binding] 260799001223 phosphate binding site [ion binding]; other site 260799001224 domain II; other site 260799001225 domain III; other site 260799001226 nucleotide binding site [chemical binding]; other site 260799001227 catalytic site [active] 260799001228 domain IV; other site 260799001229 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 260799001230 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 260799001231 substrate binding site [chemical binding]; other site 260799001232 multimerization interface [polypeptide binding]; other site 260799001233 ATP binding site [chemical binding]; other site 260799001234 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 260799001235 thiamine phosphate binding site [chemical binding]; other site 260799001236 active site 260799001237 pyrophosphate binding site [ion binding]; other site 260799001238 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 260799001239 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799001240 dimerization interface [polypeptide binding]; other site 260799001241 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 260799001242 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 260799001243 dimer interface [polypeptide binding]; other site 260799001244 putative CheW interface [polypeptide binding]; other site 260799001245 Domain of unknown function DUF77; Region: DUF77; pfam01910 260799001246 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 260799001247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799001248 dimer interface [polypeptide binding]; other site 260799001249 conserved gate region; other site 260799001250 putative PBP binding loops; other site 260799001251 ABC-ATPase subunit interface; other site 260799001252 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 260799001253 NMT1/THI5 like; Region: NMT1; pfam09084 260799001254 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 260799001255 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 260799001256 Walker A/P-loop; other site 260799001257 ATP binding site [chemical binding]; other site 260799001258 Q-loop/lid; other site 260799001259 ABC transporter signature motif; other site 260799001260 Walker B; other site 260799001261 D-loop; other site 260799001262 H-loop/switch region; other site 260799001263 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 260799001264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 260799001265 Walker A/P-loop; other site 260799001266 ATP binding site [chemical binding]; other site 260799001267 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 260799001268 ATP binding site [chemical binding]; other site 260799001269 Q-loop/lid; other site 260799001270 Q-loop/lid; other site 260799001271 ABC transporter signature motif; other site 260799001272 ABC transporter signature motif; other site 260799001273 Walker B; other site 260799001274 Walker B; other site 260799001275 D-loop; other site 260799001276 D-loop; other site 260799001277 H-loop/switch region; other site 260799001278 ABC transporter; Region: ABC_tran_2; pfam12848 260799001279 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 260799001280 Glyco_18 domain; Region: Glyco_18; smart00636 260799001281 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 260799001282 active site 260799001283 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 260799001284 Interdomain contacts; other site 260799001285 Cytokine receptor motif; other site 260799001286 Cellulose binding domain; Region: CBM_2; pfam00553 260799001287 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 260799001288 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 260799001289 catalytic residues [active] 260799001290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799001291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799001292 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 260799001293 H+ Antiporter protein; Region: 2A0121; TIGR00900 260799001294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799001295 putative substrate translocation pore; other site 260799001296 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 260799001297 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799001298 non-specific DNA binding site [nucleotide binding]; other site 260799001299 salt bridge; other site 260799001300 sequence-specific DNA binding site [nucleotide binding]; other site 260799001301 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 260799001302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799001303 putative substrate translocation pore; other site 260799001304 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 260799001305 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 260799001306 YesK-like protein; Region: YesK; pfam14150 260799001307 prolyl-tRNA synthetase; Provisional; Region: PRK08661 260799001308 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 260799001309 dimer interface [polypeptide binding]; other site 260799001310 motif 1; other site 260799001311 active site 260799001312 motif 2; other site 260799001313 motif 3; other site 260799001314 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 260799001315 anticodon binding site; other site 260799001316 zinc-binding site [ion binding]; other site 260799001317 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 260799001318 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 260799001319 nucleotide binding site [chemical binding]; other site 260799001320 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 260799001321 putative metal binding site [ion binding]; other site 260799001322 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 260799001323 putative metal binding site [ion binding]; other site 260799001324 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 260799001325 putative metal binding site [ion binding]; other site 260799001326 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 260799001327 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 260799001328 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 260799001329 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 260799001330 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 260799001331 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 260799001332 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 260799001333 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 260799001334 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 260799001335 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 260799001336 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 260799001337 Low molecular weight phosphatase family; Region: LMWPc; cd00115 260799001338 active site 260799001339 YtxH-like protein; Region: YtxH; pfam12732 260799001340 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 260799001341 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 260799001342 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 260799001343 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 260799001344 Soluble P-type ATPase [General function prediction only]; Region: COG4087 260799001345 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 260799001346 EamA-like transporter family; Region: EamA; pfam00892 260799001347 EamA-like transporter family; Region: EamA; pfam00892 260799001348 YhhN-like protein; Region: YhhN; pfam07947 260799001349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799001350 binding surface 260799001351 Tetratricopeptide repeat; Region: TPR_16; pfam13432 260799001352 TPR motif; other site 260799001353 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 260799001354 Predicted membrane protein [Function unknown]; Region: COG2510 260799001355 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 260799001356 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 260799001357 calcium/proton exchanger (cax); Region: cax; TIGR00378 260799001358 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 260799001359 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 260799001360 YfkD-like protein; Region: YfkD; pfam14167 260799001361 Radical SAM superfamily; Region: Radical_SAM; pfam04055 260799001362 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 260799001363 FeS/SAM binding site; other site 260799001364 YfkB-like domain; Region: YfkB; pfam08756 260799001365 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 260799001366 Fumarase C-terminus; Region: Fumerase_C; pfam05683 260799001367 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 260799001368 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 260799001369 NodB motif; other site 260799001370 active site 260799001371 catalytic site [active] 260799001372 Cd binding site [ion binding]; other site 260799001373 TRAM domain; Region: TRAM; pfam01938 260799001374 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 260799001375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799001376 S-adenosylmethionine binding site [chemical binding]; other site 260799001377 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 260799001378 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 260799001379 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 260799001380 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 260799001381 Int/Topo IB signature motif; other site 260799001382 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 260799001383 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799001384 non-specific DNA binding site [nucleotide binding]; other site 260799001385 salt bridge; other site 260799001386 sequence-specific DNA binding site [nucleotide binding]; other site 260799001387 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 260799001388 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799001389 non-specific DNA binding site [nucleotide binding]; other site 260799001390 salt bridge; other site 260799001391 sequence-specific DNA binding site [nucleotide binding]; other site 260799001392 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 260799001393 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799001394 non-specific DNA binding site [nucleotide binding]; other site 260799001395 salt bridge; other site 260799001396 sequence-specific DNA binding site [nucleotide binding]; other site 260799001397 phage regulatory protein, rha family; Region: phage_pRha; TIGR02681 260799001398 ORF6C domain; Region: ORF6C; pfam10552 260799001399 Helix-turn-helix domain; Region: HTH_17; cl17695 260799001400 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 260799001401 hypothetical protein; Validated; Region: PRK08116 260799001402 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799001403 Walker A motif; other site 260799001404 ATP binding site [chemical binding]; other site 260799001405 Walker B motif; other site 260799001406 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 260799001407 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 260799001408 putative metal binding site [ion binding]; other site 260799001409 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 260799001410 HNH endonuclease; Region: HNH; pfam01844 260799001411 Helix-turn-helix domain; Region: HTH_17; pfam12728 260799001412 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 260799001413 Phage Terminase; Region: Terminase_1; cl19862 260799001414 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 260799001415 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 260799001416 Phage capsid family; Region: Phage_capsid; pfam05065 260799001417 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 260799001418 oligomerization interface [polypeptide binding]; other site 260799001419 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 260799001420 Bacteriophage HK97-gp10, putative tail-component; Region: HK97-gp10_like; pfam04883 260799001421 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 260799001422 Phage-related minor tail protein [Function unknown]; Region: COG5280 260799001423 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl19842 260799001424 Domain of unknown function (DUF4515); Region: DUF4515; pfam14988 260799001425 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 260799001426 Phage tail protein; Region: Sipho_tail; pfam05709 260799001427 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 260799001428 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 260799001429 Haemolysin XhlA; Region: XhlA; pfam10779 260799001430 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 260799001431 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 260799001432 active site 260799001433 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 260799001434 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 260799001435 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 260799001436 dimerization interface 3.5A [polypeptide binding]; other site 260799001437 active site 260799001438 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 260799001439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799001440 Walker A motif; other site 260799001441 ATP binding site [chemical binding]; other site 260799001442 Walker B motif; other site 260799001443 arginine finger; other site 260799001444 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 260799001445 hypothetical protein; Validated; Region: PRK06748 260799001446 S-methylmethionine transporter; Provisional; Region: PRK11387 260799001447 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 260799001448 acetylornithine deacetylase; Validated; Region: PRK08596 260799001449 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 260799001450 metal binding site [ion binding]; metal-binding site 260799001451 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 260799001452 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799001453 sequence-specific DNA binding site [nucleotide binding]; other site 260799001454 salt bridge; other site 260799001455 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 260799001456 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 260799001457 Domain of unknown function DUF; Region: DUF204; pfam02659 260799001458 Domain of unknown function DUF; Region: DUF204; pfam02659 260799001459 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 260799001460 glutaminase A; Region: Gln_ase; TIGR03814 260799001461 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 260799001462 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 260799001463 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 260799001464 active site turn [active] 260799001465 phosphorylation site [posttranslational modification] 260799001466 Beta-lactamase; Region: Beta-lactamase; pfam00144 260799001467 Sm and related proteins; Region: Sm_like; cl00259 260799001468 heptamer interface [polypeptide binding]; other site 260799001469 Sm1 motif; other site 260799001470 hexamer interface [polypeptide binding]; other site 260799001471 RNA binding site [nucleotide binding]; other site 260799001472 Sm2 motif; other site 260799001473 Sm and related proteins; Region: Sm_like; cl00259 260799001474 heptamer interface [polypeptide binding]; other site 260799001475 Sm1 motif; other site 260799001476 hexamer interface [polypeptide binding]; other site 260799001477 RNA binding site [nucleotide binding]; other site 260799001478 Sm2 motif; other site 260799001479 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 260799001480 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 260799001481 active site 260799001482 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 260799001483 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 260799001484 active site 260799001485 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 260799001486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 260799001487 NAD(P) binding site [chemical binding]; other site 260799001488 active site 260799001489 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 260799001490 active site 260799001491 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 260799001492 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 260799001493 active site 260799001494 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 260799001495 Pyruvate formate lyase 1; Region: PFL1; cd01678 260799001496 coenzyme A binding site [chemical binding]; other site 260799001497 active site 260799001498 catalytic residues [active] 260799001499 glycine loop; other site 260799001500 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 260799001501 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 260799001502 FeS/SAM binding site; other site 260799001503 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 260799001504 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 260799001505 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 260799001506 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799001507 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 260799001508 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 260799001509 active site 260799001510 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 260799001511 TIGR01777 family protein; Region: yfcH 260799001512 putative NAD(P) binding site [chemical binding]; other site 260799001513 putative active site [active] 260799001514 recombination regulator RecX; Provisional; Region: recX; PRK14135 260799001515 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 260799001516 YpzG-like protein; Region: YpzG; pfam14139 260799001517 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 260799001518 WVELL protein; Region: WVELL; pfam14043 260799001519 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 260799001520 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 260799001521 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 260799001522 minor groove reading motif; other site 260799001523 helix-hairpin-helix signature motif; other site 260799001524 substrate binding pocket [chemical binding]; other site 260799001525 active site 260799001526 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 260799001527 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 260799001528 DNA binding and oxoG recognition site [nucleotide binding] 260799001529 small, acid-soluble spore protein, gamma-type; Region: SASP_gamma; TIGR01442 260799001530 YgaB-like protein; Region: YgaB; pfam14182 260799001531 hypothetical protein; Provisional; Region: PRK13662 260799001532 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 260799001533 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 260799001534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 260799001535 Walker A/P-loop; other site 260799001536 ATP binding site [chemical binding]; other site 260799001537 Q-loop/lid; other site 260799001538 ABC transporter signature motif; other site 260799001539 Walker B; other site 260799001540 D-loop; other site 260799001541 H-loop/switch region; other site 260799001542 Predicted membrane protein [Function unknown]; Region: COG4129 260799001543 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 260799001544 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 260799001545 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 260799001546 active site 260799001547 dimer interface [polypeptide binding]; other site 260799001548 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 260799001549 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 260799001550 active site 260799001551 FMN binding site [chemical binding]; other site 260799001552 substrate binding site [chemical binding]; other site 260799001553 3Fe-4S cluster binding site [ion binding]; other site 260799001554 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 260799001555 domain_subunit interface; other site 260799001556 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 260799001557 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 260799001558 inhibitor-cofactor binding pocket; inhibition site 260799001559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799001560 catalytic residue [active] 260799001561 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 260799001562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 260799001563 Walker A/P-loop; other site 260799001564 ATP binding site [chemical binding]; other site 260799001565 Q-loop/lid; other site 260799001566 ABC transporter signature motif; other site 260799001567 Walker B; other site 260799001568 D-loop; other site 260799001569 H-loop/switch region; other site 260799001570 ABC-2 type transporter; Region: ABC2_membrane; cl17235 260799001571 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 260799001572 Ion channel; Region: Ion_trans_2; pfam07885 260799001573 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 260799001574 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 260799001575 catalytic triad [active] 260799001576 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 260799001577 metal binding site 2 [ion binding]; metal-binding site 260799001578 putative DNA binding helix; other site 260799001579 metal binding site 1 [ion binding]; metal-binding site 260799001580 dimer interface [polypeptide binding]; other site 260799001581 structural Zn2+ binding site [ion binding]; other site 260799001582 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 260799001583 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 260799001584 hypothetical protein; Provisional; Region: PRK12378 260799001585 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 260799001586 nudix motif; other site 260799001587 Transglycosylase; Region: Transgly; pfam00912 260799001588 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 260799001589 Thioredoxin; Region: Thioredoxin_4; pfam13462 260799001590 epoxyqueuosine reductase; Region: TIGR00276 260799001591 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 260799001592 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 260799001593 HEAT-like repeat; Region: HEAT_EZ; pfam13513 260799001594 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 260799001595 Putative amidase domain; Region: Amidase_6; pfam12671 260799001596 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 260799001597 PAS fold; Region: PAS_4; pfam08448 260799001598 PAS domain S-box; Region: sensory_box; TIGR00229 260799001599 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 260799001600 putative active site [active] 260799001601 heme pocket [chemical binding]; other site 260799001602 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 260799001603 metal binding site [ion binding]; metal-binding site 260799001604 active site 260799001605 I-site; other site 260799001606 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 260799001607 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 260799001608 PrkA AAA domain; Region: AAA_PrkA; smart00763 260799001609 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 260799001610 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 260799001611 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 260799001612 heme-binding site [chemical binding]; other site 260799001613 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 260799001614 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 260799001615 Leucine rich repeat; Region: LRR_8; pfam13855 260799001616 Substrate binding site [chemical binding]; other site 260799001617 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 260799001618 Leucine rich repeat; Region: LRR_8; pfam13855 260799001619 Leucine rich repeat; Region: LRR_8; pfam13855 260799001620 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 260799001621 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 260799001622 Leucine rich repeat; Region: LRR_8; pfam13855 260799001623 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 260799001624 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 260799001625 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 260799001626 Leucine rich repeat; Region: LRR_8; pfam13855 260799001627 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 260799001628 Neuromodulin; Region: Neuromodulin; pfam06614 260799001629 RCSD region; Region: RCSD; pfam05177 260799001630 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 260799001631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799001632 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 260799001633 Coenzyme A binding pocket [chemical binding]; other site 260799001634 BCCT family transporter; Region: BCCT; pfam02028 260799001635 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 260799001636 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 260799001637 FOG: PKD repeat [General function prediction only]; Region: COG3291 260799001638 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 260799001639 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 260799001640 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 260799001641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 260799001642 Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399 260799001643 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 260799001644 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 260799001645 Cache domain; Region: Cache_1; pfam02743 260799001646 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799001647 dimerization interface [polypeptide binding]; other site 260799001648 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 260799001649 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 260799001650 dimer interface [polypeptide binding]; other site 260799001651 putative CheW interface [polypeptide binding]; other site 260799001652 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 260799001653 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 260799001654 PAS domain; Region: PAS; smart00091 260799001655 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 260799001656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799001657 ATP binding site [chemical binding]; other site 260799001658 Mg2+ binding site [ion binding]; other site 260799001659 G-X-G motif; other site 260799001660 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 260799001661 Citrate transporter; Region: CitMHS; pfam03600 260799001662 hypothetical protein; Provisional; Region: PRK12784 260799001663 NosL; Region: NosL; cl01769 260799001664 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 260799001665 Ankyrin repeat; Region: Ank; pfam00023 260799001666 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 260799001667 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 260799001668 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 260799001669 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 260799001670 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 260799001671 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 260799001672 Walker A/P-loop; other site 260799001673 ATP binding site [chemical binding]; other site 260799001674 Q-loop/lid; other site 260799001675 ABC transporter signature motif; other site 260799001676 Walker B; other site 260799001677 D-loop; other site 260799001678 H-loop/switch region; other site 260799001679 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 260799001680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799001681 dimer interface [polypeptide binding]; other site 260799001682 conserved gate region; other site 260799001683 putative PBP binding loops; other site 260799001684 ABC-ATPase subunit interface; other site 260799001685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 260799001686 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 260799001687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799001688 dimer interface [polypeptide binding]; other site 260799001689 conserved gate region; other site 260799001690 putative PBP binding loops; other site 260799001691 ABC-ATPase subunit interface; other site 260799001692 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 260799001693 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 260799001694 putative protein phosphatase; Region: PHA02239 260799001695 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 260799001696 active site 260799001697 metal binding site [ion binding]; metal-binding site 260799001698 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799001699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799001700 active site 260799001701 phosphorylation site [posttranslational modification] 260799001702 intermolecular recognition site; other site 260799001703 dimerization interface [polypeptide binding]; other site 260799001704 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799001705 DNA binding site [nucleotide binding] 260799001706 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799001707 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799001708 dimer interface [polypeptide binding]; other site 260799001709 phosphorylation site [posttranslational modification] 260799001710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799001711 ATP binding site [chemical binding]; other site 260799001712 Mg2+ binding site [ion binding]; other site 260799001713 G-X-G motif; other site 260799001714 leucyl-tRNA synthetase; Reviewed; Region: leuS; PRK12300 260799001715 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 260799001716 putative active site [active] 260799001717 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 260799001718 Cache domain; Region: Cache_1; pfam02743 260799001719 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799001720 dimerization interface [polypeptide binding]; other site 260799001721 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 260799001722 dimer interface [polypeptide binding]; other site 260799001723 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 260799001724 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 260799001725 dimer interface [polypeptide binding]; other site 260799001726 putative CheW interface [polypeptide binding]; other site 260799001727 sensory histidine kinase DcuS; Provisional; Region: PRK11086 260799001728 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 260799001729 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 260799001730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799001731 ATP binding site [chemical binding]; other site 260799001732 Mg2+ binding site [ion binding]; other site 260799001733 G-X-G motif; other site 260799001734 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 260799001735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799001736 active site 260799001737 phosphorylation site [posttranslational modification] 260799001738 intermolecular recognition site; other site 260799001739 dimerization interface [polypeptide binding]; other site 260799001740 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 260799001741 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 260799001742 Malic enzyme, N-terminal domain; Region: malic; pfam00390 260799001743 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 260799001744 putative NAD(P) binding site [chemical binding]; other site 260799001745 EamA-like transporter family; Region: EamA; pfam00892 260799001746 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 260799001747 EamA-like transporter family; Region: EamA; pfam00892 260799001748 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 260799001749 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 260799001750 DNA-binding site [nucleotide binding]; DNA binding site 260799001751 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 260799001752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799001753 homodimer interface [polypeptide binding]; other site 260799001754 catalytic residue [active] 260799001755 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799001756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799001757 Coenzyme A binding pocket [chemical binding]; other site 260799001758 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 260799001759 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799001760 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799001761 dimerization interface [polypeptide binding]; other site 260799001762 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799001763 dimer interface [polypeptide binding]; other site 260799001764 phosphorylation site [posttranslational modification] 260799001765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799001766 ATP binding site [chemical binding]; other site 260799001767 Mg2+ binding site [ion binding]; other site 260799001768 G-X-G motif; other site 260799001769 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799001770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799001771 active site 260799001772 phosphorylation site [posttranslational modification] 260799001773 intermolecular recognition site; other site 260799001774 dimerization interface [polypeptide binding]; other site 260799001775 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799001776 DNA binding site [nucleotide binding] 260799001777 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 260799001778 Arrestin_N terminal like; Region: LDB19; pfam13002 260799001779 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799001780 Coenzyme A binding pocket [chemical binding]; other site 260799001781 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 260799001782 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 260799001783 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 260799001784 catalytic loop [active] 260799001785 iron binding site [ion binding]; other site 260799001786 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 260799001787 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 260799001788 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 260799001789 [4Fe-4S] binding site [ion binding]; other site 260799001790 molybdopterin cofactor binding site; other site 260799001791 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 260799001792 molybdopterin cofactor binding site; other site 260799001793 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 260799001794 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 260799001795 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 260799001796 putative active site [active] 260799001797 catalytic site [active] 260799001798 putative metal binding site [ion binding]; other site 260799001799 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 260799001800 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 260799001801 hexamer interface [polypeptide binding]; other site 260799001802 ligand binding site [chemical binding]; other site 260799001803 putative active site [active] 260799001804 NAD(P) binding site [chemical binding]; other site 260799001805 amino acid transporter; Region: 2A0306; TIGR00909 260799001806 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 260799001807 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799001808 dimerization interface [polypeptide binding]; other site 260799001809 putative DNA binding site [nucleotide binding]; other site 260799001810 putative Zn2+ binding site [ion binding]; other site 260799001811 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 260799001812 metal-binding site [ion binding] 260799001813 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 260799001814 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 260799001815 metal-binding site [ion binding] 260799001816 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 260799001817 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 260799001818 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 260799001819 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 260799001820 active site 260799001821 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 260799001822 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799001823 non-specific DNA binding site [nucleotide binding]; other site 260799001824 salt bridge; other site 260799001825 sequence-specific DNA binding site [nucleotide binding]; other site 260799001826 Tetratricopeptide repeat; Region: TPR_12; pfam13424 260799001827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799001828 TPR motif; other site 260799001829 binding surface 260799001830 Tetratricopeptide repeat; Region: TPR_12; pfam13424 260799001831 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 260799001832 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 260799001833 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 260799001834 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 260799001835 active site 260799001836 Zn binding site [ion binding]; other site 260799001837 Uncharacterized conserved protein [Function unknown]; Region: COG0398 260799001838 Rotavirus VP2 protein; Region: Rota_VP2; pfam05087 260799001839 Transcriptional regulator PadR-like family; Region: PadR; cl17335 260799001840 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 260799001841 VanW like protein; Region: VanW; pfam04294 260799001842 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 260799001843 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 260799001844 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 260799001845 Nucleoside recognition; Region: Gate; pfam07670 260799001846 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 260799001847 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 260799001848 putative metal binding site [ion binding]; other site 260799001849 Domain of unknown function DUF21; Region: DUF21; pfam01595 260799001850 FOG: CBS domain [General function prediction only]; Region: COG0517 260799001851 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 260799001852 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 260799001853 Aspartase; Region: Aspartase; cd01357 260799001854 active sites [active] 260799001855 tetramer interface [polypeptide binding]; other site 260799001856 L-lactate permease; Region: Lactate_perm; cl00701 260799001857 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799001858 dimerization interface [polypeptide binding]; other site 260799001859 putative DNA binding site [nucleotide binding]; other site 260799001860 putative Zn2+ binding site [ion binding]; other site 260799001861 acid-soluble spore protein H; Provisional; Region: sspH; PRK01625 260799001862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799001863 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799001864 putative substrate translocation pore; other site 260799001865 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 260799001866 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 260799001867 siderophore binding site; other site 260799001868 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 260799001869 ABC-ATPase subunit interface; other site 260799001870 dimer interface [polypeptide binding]; other site 260799001871 putative PBP binding regions; other site 260799001872 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 260799001873 ABC-ATPase subunit interface; other site 260799001874 dimer interface [polypeptide binding]; other site 260799001875 putative PBP binding regions; other site 260799001876 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 260799001877 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 260799001878 Walker A/P-loop; other site 260799001879 ATP binding site [chemical binding]; other site 260799001880 Q-loop/lid; other site 260799001881 ABC transporter signature motif; other site 260799001882 Walker B; other site 260799001883 D-loop; other site 260799001884 H-loop/switch region; other site 260799001885 Methyltransferase domain; Region: Methyltransf_31; pfam13847 260799001886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799001887 S-adenosylmethionine binding site [chemical binding]; other site 260799001888 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 260799001889 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 260799001890 substrate-cofactor binding pocket; other site 260799001891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799001892 catalytic residue [active] 260799001893 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 260799001894 nudix motif; other site 260799001895 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 260799001896 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 260799001897 metal ion-dependent adhesion site (MIDAS); other site 260799001898 MoxR-like ATPases [General function prediction only]; Region: COG0714 260799001899 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799001900 Walker A motif; other site 260799001901 ATP binding site [chemical binding]; other site 260799001902 Walker B motif; other site 260799001903 arginine finger; other site 260799001904 cardiolipin synthetase; Reviewed; Region: PRK12452 260799001905 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 260799001906 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 260799001907 putative active site [active] 260799001908 catalytic site [active] 260799001909 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 260799001910 putative active site [active] 260799001911 catalytic site [active] 260799001912 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 260799001913 PAS domain; Region: PAS_9; pfam13426 260799001914 putative active site [active] 260799001915 heme pocket [chemical binding]; other site 260799001916 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 260799001917 metal binding site [ion binding]; metal-binding site 260799001918 active site 260799001919 I-site; other site 260799001920 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 260799001921 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 260799001922 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 260799001923 Spore germination protein; Region: Spore_permease; cl17796 260799001924 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 260799001925 DNA-binding site [nucleotide binding]; DNA binding site 260799001926 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 260799001927 UTRA domain; Region: UTRA; pfam07702 260799001928 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 260799001929 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 260799001930 active site turn [active] 260799001931 phosphorylation site [posttranslational modification] 260799001932 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 260799001933 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 260799001934 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 260799001935 Ca binding site [ion binding]; other site 260799001936 active site 260799001937 catalytic site [active] 260799001938 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 260799001939 Spore germination protein; Region: Spore_permease; cl17796 260799001940 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 260799001941 CAAX protease self-immunity; Region: Abi; pfam02517 260799001942 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 260799001943 Phosphotransferase enzyme family; Region: APH; pfam01636 260799001944 active site 260799001945 ATP binding site [chemical binding]; other site 260799001946 substrate binding site [chemical binding]; other site 260799001947 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 260799001948 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 260799001949 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 260799001950 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 260799001951 Walker A/P-loop; other site 260799001952 ATP binding site [chemical binding]; other site 260799001953 Q-loop/lid; other site 260799001954 ABC transporter signature motif; other site 260799001955 Walker B; other site 260799001956 D-loop; other site 260799001957 H-loop/switch region; other site 260799001958 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 260799001959 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 260799001960 substrate binding pocket [chemical binding]; other site 260799001961 membrane-bound complex binding site; other site 260799001962 hinge residues; other site 260799001963 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 260799001964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799001965 dimer interface [polypeptide binding]; other site 260799001966 conserved gate region; other site 260799001967 putative PBP binding loops; other site 260799001968 ABC-ATPase subunit interface; other site 260799001969 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 260799001970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799001971 dimer interface [polypeptide binding]; other site 260799001972 conserved gate region; other site 260799001973 putative PBP binding loops; other site 260799001974 ABC-ATPase subunit interface; other site 260799001975 S-methylmethionine transporter; Provisional; Region: PRK11387 260799001976 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 260799001977 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 260799001978 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 260799001979 nucleotide binding site/active site [active] 260799001980 HIT family signature motif; other site 260799001981 catalytic residue [active] 260799001982 RNA polymerase sigma factor; Provisional; Region: PRK12542 260799001983 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799001984 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 260799001985 DNA binding residues [nucleotide binding] 260799001986 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 260799001987 Predicted transcriptional regulator [Transcription]; Region: COG2378 260799001988 HTH domain; Region: HTH_11; pfam08279 260799001989 WYL domain; Region: WYL; pfam13280 260799001990 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 260799001991 folate binding site [chemical binding]; other site 260799001992 NADP+ binding site [chemical binding]; other site 260799001993 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 260799001994 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799001995 dimerization interface [polypeptide binding]; other site 260799001996 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799001997 dimer interface [polypeptide binding]; other site 260799001998 phosphorylation site [posttranslational modification] 260799001999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799002000 ATP binding site [chemical binding]; other site 260799002001 Mg2+ binding site [ion binding]; other site 260799002002 G-X-G motif; other site 260799002003 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799002004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799002005 active site 260799002006 phosphorylation site [posttranslational modification] 260799002007 intermolecular recognition site; other site 260799002008 dimerization interface [polypeptide binding]; other site 260799002009 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799002010 DNA binding site [nucleotide binding] 260799002011 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 260799002012 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 260799002013 Sulfate transporter family; Region: Sulfate_transp; pfam00916 260799002014 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 260799002015 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 260799002016 Ligand Binding Site [chemical binding]; other site 260799002017 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 260799002018 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 260799002019 peptide binding site [polypeptide binding]; other site 260799002020 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 260799002021 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 260799002022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799002023 dimer interface [polypeptide binding]; other site 260799002024 conserved gate region; other site 260799002025 putative PBP binding loops; other site 260799002026 ABC-ATPase subunit interface; other site 260799002027 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 260799002028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799002029 dimer interface [polypeptide binding]; other site 260799002030 conserved gate region; other site 260799002031 putative PBP binding loops; other site 260799002032 ABC-ATPase subunit interface; other site 260799002033 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 260799002034 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 260799002035 Walker A/P-loop; other site 260799002036 ATP binding site [chemical binding]; other site 260799002037 Q-loop/lid; other site 260799002038 ABC transporter signature motif; other site 260799002039 Walker B; other site 260799002040 D-loop; other site 260799002041 H-loop/switch region; other site 260799002042 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 260799002043 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 260799002044 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 260799002045 Q-loop/lid; other site 260799002046 ABC transporter signature motif; other site 260799002047 Walker B; other site 260799002048 D-loop; other site 260799002049 H-loop/switch region; other site 260799002050 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 260799002051 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 260799002052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799002053 putative substrate translocation pore; other site 260799002054 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 260799002055 Transcriptional regulators [Transcription]; Region: MarR; COG1846 260799002056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799002057 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799002058 putative substrate translocation pore; other site 260799002059 Transcriptional regulators [Transcription]; Region: PurR; COG1609 260799002060 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 260799002061 DNA binding site [nucleotide binding] 260799002062 domain linker motif; other site 260799002063 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 260799002064 dimerization interface [polypeptide binding]; other site 260799002065 ligand binding site [chemical binding]; other site 260799002066 sodium binding site [ion binding]; other site 260799002067 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 260799002068 substrate binding site [chemical binding]; other site 260799002069 dimer interface [polypeptide binding]; other site 260799002070 ATP binding site [chemical binding]; other site 260799002071 D-ribose pyranase; Provisional; Region: PRK11797 260799002072 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 260799002073 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 260799002074 Walker A/P-loop; other site 260799002075 ATP binding site [chemical binding]; other site 260799002076 Q-loop/lid; other site 260799002077 ABC transporter signature motif; other site 260799002078 Walker B; other site 260799002079 D-loop; other site 260799002080 H-loop/switch region; other site 260799002081 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 260799002082 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 260799002083 TM-ABC transporter signature motif; other site 260799002084 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 260799002085 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 260799002086 ligand binding site [chemical binding]; other site 260799002087 dimerization interface [polypeptide binding]; other site 260799002088 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 260799002089 active site 260799002090 intersubunit interactions; other site 260799002091 catalytic residue [active] 260799002092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 260799002093 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 260799002094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799002095 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799002096 putative substrate translocation pore; other site 260799002097 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 260799002098 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 260799002099 putative NAD(P) binding site [chemical binding]; other site 260799002100 catalytic Zn binding site [ion binding]; other site 260799002101 Ion channel; Region: Ion_trans_2; pfam07885 260799002102 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 260799002103 Zn binding site [ion binding]; other site 260799002104 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 260799002105 putative catalytic site [active] 260799002106 metal binding site A [ion binding]; metal-binding site 260799002107 phosphate binding site [ion binding]; other site 260799002108 metal binding site C [ion binding]; metal-binding site 260799002109 metal binding site B [ion binding]; metal-binding site 260799002110 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 260799002111 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 260799002112 dimer interface [polypeptide binding]; other site 260799002113 active site 260799002114 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 260799002115 substrate binding site [chemical binding]; other site 260799002116 catalytic residue [active] 260799002117 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 260799002118 FAD binding domain; Region: FAD_binding_4; pfam01565 260799002119 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 260799002120 VanZ like family; Region: VanZ; pfam04892 260799002121 RDD family; Region: RDD; pfam06271 260799002122 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 260799002123 IncA protein; Region: IncA; pfam04156 260799002124 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 260799002125 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 260799002126 dimer interface [polypeptide binding]; other site 260799002127 putative CheW interface [polypeptide binding]; other site 260799002128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 260799002129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 260799002130 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 260799002131 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799002132 non-specific DNA binding site [nucleotide binding]; other site 260799002133 salt bridge; other site 260799002134 sequence-specific DNA binding site [nucleotide binding]; other site 260799002135 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 260799002136 active site 260799002137 catalytic site [active] 260799002138 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 260799002139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799002140 putative substrate translocation pore; other site 260799002141 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 260799002142 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cl09943 260799002143 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 260799002144 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 260799002145 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 260799002146 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 260799002147 Sulfate transporter family; Region: Sulfate_transp; cl19250 260799002148 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 260799002149 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799002150 non-specific DNA binding site [nucleotide binding]; other site 260799002151 salt bridge; other site 260799002152 sequence-specific DNA binding site [nucleotide binding]; other site 260799002153 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799002154 Coenzyme A binding pocket [chemical binding]; other site 260799002155 Protein of unknown function (DUF4022); Region: DUF4022; pfam13214 260799002156 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 260799002157 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 260799002158 TrkA-N domain; Region: TrkA_N; pfam02254 260799002159 TrkA-C domain; Region: TrkA_C; pfam02080 260799002160 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 260799002161 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 260799002162 Subunit I/III interface [polypeptide binding]; other site 260799002163 Subunit III/IV interface [polypeptide binding]; other site 260799002164 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 260799002165 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 260799002166 D-pathway; other site 260799002167 Putative ubiquinol binding site [chemical binding]; other site 260799002168 Low-spin heme (heme b) binding site [chemical binding]; other site 260799002169 Putative water exit pathway; other site 260799002170 Binuclear center (heme o3/CuB) [ion binding]; other site 260799002171 K-pathway; other site 260799002172 Putative proton exit pathway; other site 260799002173 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 260799002174 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 260799002175 The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212 260799002176 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 260799002177 putative active site [active] 260799002178 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 260799002179 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 260799002180 metal binding site [ion binding]; metal-binding site 260799002181 dimer interface [polypeptide binding]; other site 260799002182 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 260799002183 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 260799002184 Na binding site [ion binding]; other site 260799002185 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 260799002186 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 260799002187 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 260799002188 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 260799002189 Nucleoside recognition; Region: Gate; pfam07670 260799002190 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 260799002191 Nucleoside recognition; Region: Gate; pfam07670 260799002192 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 260799002193 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 260799002194 G1 box; other site 260799002195 GTP/Mg2+ binding site [chemical binding]; other site 260799002196 Switch I region; other site 260799002197 G2 box; other site 260799002198 G3 box; other site 260799002199 Switch II region; other site 260799002200 G4 box; other site 260799002201 G5 box; other site 260799002202 FeoA domain; Region: FeoA; pfam04023 260799002203 phosphate binding protein; Region: ptsS_2; TIGR02136 260799002204 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 260799002205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799002206 dimer interface [polypeptide binding]; other site 260799002207 conserved gate region; other site 260799002208 putative PBP binding loops; other site 260799002209 ABC-ATPase subunit interface; other site 260799002210 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 260799002211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799002212 dimer interface [polypeptide binding]; other site 260799002213 conserved gate region; other site 260799002214 putative PBP binding loops; other site 260799002215 ABC-ATPase subunit interface; other site 260799002216 AAA domain; Region: AAA_17; cl19128 260799002217 AAA domain; Region: AAA_33; pfam13671 260799002218 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 260799002219 MMPL family; Region: MMPL; cl14618 260799002220 MMPL family; Region: MMPL; cl14618 260799002221 FOG: CBS domain [General function prediction only]; Region: COG0517 260799002222 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 260799002223 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 260799002224 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 260799002225 Bacterial SH3 domain; Region: SH3_3; pfam08239 260799002226 Bacterial SH3 domain; Region: SH3_3; pfam08239 260799002227 Bacterial SH3 domain; Region: SH3_3; pfam08239 260799002228 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 260799002229 Peptidase family M23; Region: Peptidase_M23; pfam01551 260799002230 Putative transcription activator [Transcription]; Region: TenA; COG0819 260799002231 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 260799002232 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 260799002233 Walker A/P-loop; other site 260799002234 ATP binding site [chemical binding]; other site 260799002235 Q-loop/lid; other site 260799002236 ABC transporter signature motif; other site 260799002237 Walker B; other site 260799002238 D-loop; other site 260799002239 H-loop/switch region; other site 260799002240 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 260799002241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799002242 dimer interface [polypeptide binding]; other site 260799002243 conserved gate region; other site 260799002244 putative PBP binding loops; other site 260799002245 ABC-ATPase subunit interface; other site 260799002246 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 260799002247 NMT1/THI5 like; Region: NMT1; pfam09084 260799002248 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 260799002249 thiamine phosphate binding site [chemical binding]; other site 260799002250 active site 260799002251 pyrophosphate binding site [ion binding]; other site 260799002252 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 260799002253 FAD dependent oxidoreductase; Region: DAO; pfam01266 260799002254 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 260799002255 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 260799002256 thiS-thiF/thiG interaction site; other site 260799002257 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 260799002258 ThiS interaction site; other site 260799002259 putative active site [active] 260799002260 tetramer interface [polypeptide binding]; other site 260799002261 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 260799002262 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 260799002263 ATP binding site [chemical binding]; other site 260799002264 substrate interface [chemical binding]; other site 260799002265 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 260799002266 dimer interface [polypeptide binding]; other site 260799002267 substrate binding site [chemical binding]; other site 260799002268 ATP binding site [chemical binding]; other site 260799002269 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 260799002270 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 260799002271 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 260799002272 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 260799002273 potassium-transporting ATPase subunit C; Provisional; Region: PRK13997 260799002274 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 260799002275 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 260799002276 Ligand Binding Site [chemical binding]; other site 260799002277 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 260799002278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799002279 putative substrate translocation pore; other site 260799002280 Transcriptional regulators [Transcription]; Region: MarR; COG1846 260799002281 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 260799002282 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 260799002283 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 260799002284 active site 260799002285 nucleophile elbow; other site 260799002286 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 260799002287 oxidoreductase; Provisional; Region: PRK06128 260799002288 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 260799002289 NAD binding site [chemical binding]; other site 260799002290 metal binding site [ion binding]; metal-binding site 260799002291 active site 260799002292 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 260799002293 putative substrate binding site [chemical binding]; other site 260799002294 putative ATP binding site [chemical binding]; other site 260799002295 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 260799002296 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 260799002297 substrate binding [chemical binding]; other site 260799002298 active site 260799002299 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 260799002300 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 260799002301 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 260799002302 active site turn [active] 260799002303 phosphorylation site [posttranslational modification] 260799002304 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 260799002305 Transcriptional regulators [Transcription]; Region: PurR; COG1609 260799002306 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 260799002307 DNA binding site [nucleotide binding] 260799002308 domain linker motif; other site 260799002309 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 260799002310 dimerization interface [polypeptide binding]; other site 260799002311 ligand binding site [chemical binding]; other site 260799002312 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 260799002313 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 260799002314 catalytic residues [active] 260799002315 putative disulfide oxidoreductase; Provisional; Region: PRK03113 260799002316 YhdB-like protein; Region: YhdB; pfam14148 260799002317 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 260799002318 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 260799002319 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 260799002320 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 260799002321 putative FMN binding site [chemical binding]; other site 260799002322 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 260799002323 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 260799002324 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799002325 Transcriptional regulators [Transcription]; Region: MarR; COG1846 260799002326 putative DNA binding site [nucleotide binding]; other site 260799002327 putative Zn2+ binding site [ion binding]; other site 260799002328 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 260799002329 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 260799002330 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 260799002331 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 260799002332 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 260799002333 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 260799002334 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 260799002335 active site residue [active] 260799002336 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 260799002337 putative homodimer interface [polypeptide binding]; other site 260799002338 putative homotetramer interface [polypeptide binding]; other site 260799002339 putative metal binding site [ion binding]; other site 260799002340 putative homodimer-homodimer interface [polypeptide binding]; other site 260799002341 putative allosteric switch controlling residues; other site 260799002342 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 260799002343 CPxP motif; other site 260799002344 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 260799002345 active site residue [active] 260799002346 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 260799002347 active site residue [active] 260799002348 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 260799002349 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 260799002350 CPxP motif; other site 260799002351 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 260799002352 active site residue [active] 260799002353 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 260799002354 active site residue [active] 260799002355 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 260799002356 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 260799002357 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 260799002358 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 260799002359 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 260799002360 NADP binding site [chemical binding]; other site 260799002361 dimer interface [polypeptide binding]; other site 260799002362 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 260799002363 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 260799002364 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 260799002365 PhoU domain; Region: PhoU; pfam01895 260799002366 PhoU domain; Region: PhoU; pfam01895 260799002367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799002368 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799002369 putative substrate translocation pore; other site 260799002370 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 260799002371 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 260799002372 HTH domain; Region: HTH_11; pfam08279 260799002373 Mga helix-turn-helix domain; Region: Mga; pfam05043 260799002374 PRD domain; Region: PRD; pfam00874 260799002375 PRD domain; Region: PRD; pfam00874 260799002376 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 260799002377 active site 260799002378 P-loop; other site 260799002379 phosphorylation site [posttranslational modification] 260799002380 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 260799002381 active site 260799002382 phosphorylation site [posttranslational modification] 260799002383 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 260799002384 active site 260799002385 methionine cluster; other site 260799002386 phosphorylation site [posttranslational modification] 260799002387 metal binding site [ion binding]; metal-binding site 260799002388 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 260799002389 active site 260799002390 P-loop; other site 260799002391 phosphorylation site [posttranslational modification] 260799002392 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 260799002393 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 260799002394 Bacterial SH3 domain; Region: SH3_3; pfam08239 260799002395 Bacterial SH3 domain homologues; Region: SH3b; smart00287 260799002396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 260799002397 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 260799002398 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 260799002399 FtsX-like permease family; Region: FtsX; pfam02687 260799002400 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 260799002401 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 260799002402 Walker A/P-loop; other site 260799002403 ATP binding site [chemical binding]; other site 260799002404 Q-loop/lid; other site 260799002405 ABC transporter signature motif; other site 260799002406 Walker B; other site 260799002407 D-loop; other site 260799002408 H-loop/switch region; other site 260799002409 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 260799002410 HlyD family secretion protein; Region: HlyD_3; pfam13437 260799002411 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 260799002412 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 260799002413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799002414 dimer interface [polypeptide binding]; other site 260799002415 conserved gate region; other site 260799002416 ABC-ATPase subunit interface; other site 260799002417 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 260799002418 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 260799002419 dimanganese center [ion binding]; other site 260799002420 CotJB protein; Region: CotJB; pfam12652 260799002421 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 260799002422 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 260799002423 active site 260799002424 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 260799002425 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 260799002426 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 260799002427 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 260799002428 putative DNA binding site [nucleotide binding]; other site 260799002429 putative homodimer interface [polypeptide binding]; other site 260799002430 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 260799002431 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 260799002432 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 260799002433 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 260799002434 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 260799002435 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 260799002436 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 260799002437 active site 260799002438 metal binding site [ion binding]; metal-binding site 260799002439 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 260799002440 Interdomain contacts; other site 260799002441 Cytokine receptor motif; other site 260799002442 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 260799002443 amino acid transporter; Region: 2A0306; TIGR00909 260799002444 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 260799002445 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 260799002446 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 260799002447 DNA topoisomerase VI, subunit B [DNA replication, recombination, and repair]; Region: COG1389 260799002448 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 260799002449 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 260799002450 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 260799002451 putative active site [active] 260799002452 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 260799002453 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 260799002454 putative active site [active] 260799002455 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 260799002456 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 260799002457 active site turn [active] 260799002458 phosphorylation site [posttranslational modification] 260799002459 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 260799002460 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 260799002461 DoxX; Region: DoxX; pfam07681 260799002462 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 260799002463 hypothetical protein; Provisional; Region: PRK06770 260799002464 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 260799002465 EamA-like transporter family; Region: EamA; pfam00892 260799002466 EamA-like transporter family; Region: EamA; pfam00892 260799002467 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 260799002468 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 260799002469 putative DNA binding site [nucleotide binding]; other site 260799002470 putative Zn2+ binding site [ion binding]; other site 260799002471 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 260799002472 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799002473 Coenzyme A binding pocket [chemical binding]; other site 260799002474 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 260799002475 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 260799002476 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799002477 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799002478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799002479 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799002480 putative substrate translocation pore; other site 260799002481 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799002482 putative DNA binding site [nucleotide binding]; other site 260799002483 putative Zn2+ binding site [ion binding]; other site 260799002484 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 260799002485 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 260799002486 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 260799002487 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 260799002488 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 260799002489 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799002490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799002491 putative substrate translocation pore; other site 260799002492 intracellular protease, PfpI family; Region: PfpI; TIGR01382 260799002493 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 260799002494 proposed catalytic triad [active] 260799002495 conserved cys residue [active] 260799002496 hydroperoxidase II; Provisional; Region: katE; PRK11249 260799002497 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 260799002498 tetramer interface [polypeptide binding]; other site 260799002499 heme binding pocket [chemical binding]; other site 260799002500 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 260799002501 conserved cys residue [active] 260799002502 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 260799002503 arginine:agmatin antiporter; Provisional; Region: PRK10644 260799002504 Spore germination protein; Region: Spore_permease; cl17796 260799002505 glutamate racemase; Provisional; Region: PRK00865 260799002506 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 260799002507 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 260799002508 tetrameric interface [polypeptide binding]; other site 260799002509 activator binding site; other site 260799002510 NADP binding site [chemical binding]; other site 260799002511 substrate binding site [chemical binding]; other site 260799002512 catalytic residues [active] 260799002513 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 260799002514 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 260799002515 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 260799002516 Walker A/P-loop; other site 260799002517 ATP binding site [chemical binding]; other site 260799002518 Q-loop/lid; other site 260799002519 ABC transporter signature motif; other site 260799002520 Walker B; other site 260799002521 D-loop; other site 260799002522 H-loop/switch region; other site 260799002523 cystine transporter subunit; Provisional; Region: PRK11260 260799002524 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 260799002525 substrate binding pocket [chemical binding]; other site 260799002526 membrane-bound complex binding site; other site 260799002527 hinge residues; other site 260799002528 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 260799002529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799002530 dimer interface [polypeptide binding]; other site 260799002531 conserved gate region; other site 260799002532 putative PBP binding loops; other site 260799002533 ABC-ATPase subunit interface; other site 260799002534 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 260799002535 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 260799002536 Walker A/P-loop; other site 260799002537 ATP binding site [chemical binding]; other site 260799002538 Q-loop/lid; other site 260799002539 ABC transporter signature motif; other site 260799002540 Walker B; other site 260799002541 D-loop; other site 260799002542 H-loop/switch region; other site 260799002543 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 260799002544 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 260799002545 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 260799002546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 260799002547 Protein of unknown function (DUF445); Region: DUF445; pfam04286 260799002548 hypothetical protein; Provisional; Region: PRK13676 260799002549 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 260799002550 acetolactate synthase; Reviewed; Region: PRK08617 260799002551 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 260799002552 PYR/PP interface [polypeptide binding]; other site 260799002553 dimer interface [polypeptide binding]; other site 260799002554 TPP binding site [chemical binding]; other site 260799002555 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 260799002556 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 260799002557 TPP-binding site [chemical binding]; other site 260799002558 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 260799002559 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 260799002560 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 260799002561 active site 260799002562 DNA binding site [nucleotide binding] 260799002563 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 260799002564 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799002565 active site 260799002566 motif I; other site 260799002567 motif II; other site 260799002568 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 260799002569 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799002570 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 260799002571 Cna protein B-type domain; Region: Cna_B; pfam05738 260799002572 Cna protein B-type domain; Region: Cna_B; pfam05738 260799002573 Cna protein B-type domain; Region: Cna_B; pfam05738 260799002574 Cna protein B-type domain; Region: Cna_B; pfam05738 260799002575 Cna protein B-type domain; Region: Cna_B; pfam05738 260799002576 WTX protein; Region: WTX; pfam09422 260799002577 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 260799002578 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 260799002579 FeS/SAM binding site; other site 260799002580 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 260799002581 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 260799002582 acyl-activating enzyme (AAE) consensus motif; other site 260799002583 putative AMP binding site [chemical binding]; other site 260799002584 putative active site [active] 260799002585 putative CoA binding site [chemical binding]; other site 260799002586 high affinity sulphate transporter 1; Region: sulP; TIGR00815 260799002587 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 260799002588 Sulfate transporter family; Region: Sulfate_transp; cl19250 260799002589 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 260799002590 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 260799002591 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 260799002592 ATP binding site [chemical binding]; other site 260799002593 putative Mg++ binding site [ion binding]; other site 260799002594 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 260799002595 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 260799002596 nucleotide binding region [chemical binding]; other site 260799002597 ATP-binding site [chemical binding]; other site 260799002598 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 260799002599 stage V sporulation protein B; Region: spore_V_B; TIGR02900 260799002600 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 260799002601 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 260799002602 S-layer homology domain; Region: SLH; pfam00395 260799002603 S-layer homology domain; Region: SLH; pfam00395 260799002604 S-layer homology domain; Region: SLH; pfam00395 260799002605 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 260799002606 S-layer homology domain; Region: SLH; pfam00395 260799002607 S-layer homology domain; Region: SLH; pfam00395 260799002608 S-layer homology domain; Region: SLH; pfam00395 260799002609 DHHW protein; Region: DHHW; pfam14286 260799002610 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 260799002611 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 260799002612 enoyl-CoA hydratase; Provisional; Region: PRK07659 260799002613 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 260799002614 substrate binding site [chemical binding]; other site 260799002615 oxyanion hole (OAH) forming residues; other site 260799002616 trimer interface [polypeptide binding]; other site 260799002617 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 260799002618 metal binding site [ion binding]; metal-binding site 260799002619 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 260799002620 putative oligomer interface [polypeptide binding]; other site 260799002621 putative active site [active] 260799002622 metal binding site [ion binding]; metal-binding site 260799002623 S-layer homology domain; Region: SLH; pfam00395 260799002624 S-layer homology domain; Region: SLH; pfam00395 260799002625 S-layer homology domain; Region: SLH; pfam00395 260799002626 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 260799002627 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 260799002628 active site 260799002629 metal binding site [ion binding]; metal-binding site 260799002630 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 260799002631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799002632 S-adenosylmethionine binding site [chemical binding]; other site 260799002633 proline racemase; Provisional; Region: PRK13969 260799002634 hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687 260799002635 ornithine cyclodeaminase; Validated; Region: PRK08618 260799002636 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 260799002637 Yip1 domain; Region: Yip1; pfam04893 260799002638 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 260799002639 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 260799002640 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 260799002641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799002642 dimer interface [polypeptide binding]; other site 260799002643 conserved gate region; other site 260799002644 putative PBP binding loops; other site 260799002645 ABC-ATPase subunit interface; other site 260799002646 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 260799002647 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 260799002648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799002649 dimer interface [polypeptide binding]; other site 260799002650 conserved gate region; other site 260799002651 putative PBP binding loops; other site 260799002652 ABC-ATPase subunit interface; other site 260799002653 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 260799002654 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 260799002655 Walker A/P-loop; other site 260799002656 ATP binding site [chemical binding]; other site 260799002657 Q-loop/lid; other site 260799002658 ABC transporter signature motif; other site 260799002659 Walker B; other site 260799002660 D-loop; other site 260799002661 H-loop/switch region; other site 260799002662 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 260799002663 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 260799002664 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 260799002665 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 260799002666 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 260799002667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799002668 putative substrate translocation pore; other site 260799002669 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 260799002670 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 260799002671 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 260799002672 putative active site [active] 260799002673 heme pocket [chemical binding]; other site 260799002674 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 260799002675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799002676 ATP binding site [chemical binding]; other site 260799002677 Mg2+ binding site [ion binding]; other site 260799002678 G-X-G motif; other site 260799002679 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 260799002680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799002681 active site 260799002682 phosphorylation site [posttranslational modification] 260799002683 intermolecular recognition site; other site 260799002684 dimerization interface [polypeptide binding]; other site 260799002685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 260799002686 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 260799002687 putative metal binding site [ion binding]; other site 260799002688 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 260799002689 putative metal binding site [ion binding]; other site 260799002690 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 260799002691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 260799002692 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 260799002693 Protein of unknown function (DUF524); Region: DUF524; pfam04411 260799002694 Tic20-like protein; Region: Tic20; pfam09685 260799002695 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 260799002696 DNA binding residues [nucleotide binding] 260799002697 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 260799002698 dimer interface [polypeptide binding]; other site 260799002699 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 260799002700 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 260799002701 replicative DNA helicase; Provisional; Region: PRK06749 260799002702 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 260799002703 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 260799002704 Walker A motif; other site 260799002705 ATP binding site [chemical binding]; other site 260799002706 Walker B motif; other site 260799002707 DNA binding loops [nucleotide binding] 260799002708 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 260799002709 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 260799002710 Predicted transcriptional regulators [Transcription]; Region: COG1378 260799002711 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 260799002712 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 260799002713 C-terminal domain interface [polypeptide binding]; other site 260799002714 sugar binding site [chemical binding]; other site 260799002715 hypothetical protein; Provisional; Region: PRK10621 260799002716 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799002717 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799002718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799002719 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799002720 putative substrate translocation pore; other site 260799002721 Predicted permease; Region: DUF318; cl17795 260799002722 Predicted permease; Region: DUF318; cl17795 260799002723 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 260799002724 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 260799002725 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 260799002726 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 260799002727 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 260799002728 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 260799002729 CGNR zinc finger; Region: zf-CGNR; pfam11706 260799002730 HPP family; Region: HPP; pfam04982 260799002731 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 260799002732 Male sterility protein; Region: NAD_binding_4; pfam07993 260799002733 putative NAD(P) binding site [chemical binding]; other site 260799002734 active site 260799002735 putative substrate binding site [chemical binding]; other site 260799002736 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799002737 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 260799002738 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799002739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799002740 YmzC-like protein; Region: YmzC; pfam14157 260799002741 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 260799002742 Transcriptional regulators [Transcription]; Region: MarR; COG1846 260799002743 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 260799002744 putative DNA binding site [nucleotide binding]; other site 260799002745 putative Zn2+ binding site [ion binding]; other site 260799002746 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 260799002747 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 260799002748 ATP synthase I chain; Region: ATP_synt_I; pfam03899 260799002749 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 260799002750 VanZ like family; Region: VanZ; pfam04892 260799002751 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 260799002752 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 260799002753 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 260799002754 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 260799002755 dihydroxyacetone kinase; Provisional; Region: PRK14479 260799002756 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 260799002757 DAK2 domain; Region: Dak2; pfam02734 260799002758 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 260799002759 Predicted transcriptional regulator [Transcription]; Region: COG1959 260799002760 Rrf2 family protein; Region: rrf2_super; TIGR00738 260799002761 CAAX protease self-immunity; Region: Abi; pfam02517 260799002762 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 260799002763 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 260799002764 Zn2+ binding site [ion binding]; other site 260799002765 Mg2+ binding site [ion binding]; other site 260799002766 S-layer homology domain; Region: SLH; pfam00395 260799002767 S-layer homology domain; Region: SLH; pfam00395 260799002768 S-layer homology domain; Region: SLH; pfam00395 260799002769 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 260799002770 Transcriptional regulators [Transcription]; Region: MarR; COG1846 260799002771 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 260799002772 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 260799002773 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 260799002774 Heat induced stress protein YflT; Region: YflT; pfam11181 260799002775 CsbD-like; Region: CsbD; pfam05532 260799002776 Predicted membrane protein [Function unknown]; Region: COG2261 260799002777 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 260799002778 anti sigma factor interaction site; other site 260799002779 regulatory phosphorylation site [posttranslational modification]; other site 260799002780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799002781 ATP binding site [chemical binding]; other site 260799002782 Mg2+ binding site [ion binding]; other site 260799002783 G-X-G motif; other site 260799002784 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 260799002785 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799002786 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 260799002787 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 260799002788 DNA binding residues [nucleotide binding] 260799002789 Ferritin-like domain; Region: Ferritin; pfam00210 260799002790 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 260799002791 dinuclear metal binding motif [ion binding]; other site 260799002792 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799002793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799002794 active site 260799002795 phosphorylation site [posttranslational modification] 260799002796 intermolecular recognition site; other site 260799002797 dimerization interface [polypeptide binding]; other site 260799002798 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 260799002799 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 260799002800 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 260799002801 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 260799002802 CHASE3 domain; Region: CHASE3; pfam05227 260799002803 HAMP domain; Region: HAMP; pfam00672 260799002804 GAF domain; Region: GAF_2; pfam13185 260799002805 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799002806 Borna disease virus P24 protein; Region: BDV_P24; pfam06595 260799002807 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799002808 dimer interface [polypeptide binding]; other site 260799002809 phosphorylation site [posttranslational modification] 260799002810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799002811 ATP binding site [chemical binding]; other site 260799002812 Mg2+ binding site [ion binding]; other site 260799002813 G-X-G motif; other site 260799002814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799002815 active site 260799002816 phosphorylation site [posttranslational modification] 260799002817 intermolecular recognition site; other site 260799002818 dimerization interface [polypeptide binding]; other site 260799002819 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 260799002820 Heat induced stress protein YflT; Region: YflT; pfam11181 260799002821 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 260799002822 hypothetical protein; Provisional; Region: PRK12856 260799002823 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 260799002824 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 260799002825 NADP binding site [chemical binding]; other site 260799002826 dimer interface [polypeptide binding]; other site 260799002827 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 260799002828 YhzD-like protein; Region: YhzD; pfam14120 260799002829 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 260799002830 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 260799002831 active site 260799002832 metal binding site [ion binding]; metal-binding site 260799002833 DNA binding site [nucleotide binding] 260799002834 AAA domain; Region: AAA_23; pfam13476 260799002835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 260799002836 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 260799002837 Probable transposase; Region: OrfB_IS605; pfam01385 260799002838 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 260799002839 AAA domain; Region: AAA_27; pfam13514 260799002840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 260799002841 Q-loop/lid; other site 260799002842 ABC transporter signature motif; other site 260799002843 Walker B; other site 260799002844 D-loop; other site 260799002845 H-loop/switch region; other site 260799002846 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 260799002847 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 260799002848 generic binding surface II; other site 260799002849 generic binding surface I; other site 260799002850 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 260799002851 Zn2+ binding site [ion binding]; other site 260799002852 Mg2+ binding site [ion binding]; other site 260799002853 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799002854 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799002855 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 260799002856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799002857 putative substrate translocation pore; other site 260799002858 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 260799002859 Zn binding site [ion binding]; other site 260799002860 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 260799002861 Zn binding site [ion binding]; other site 260799002862 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 260799002863 Zn binding site [ion binding]; other site 260799002864 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 260799002865 Zn binding site [ion binding]; other site 260799002866 Tetratricopeptide repeat; Region: TPR_12; pfam13424 260799002867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799002868 TPR motif; other site 260799002869 binding surface 260799002870 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799002871 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 260799002872 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 260799002873 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 260799002874 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 260799002875 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799002876 non-specific DNA binding site [nucleotide binding]; other site 260799002877 salt bridge; other site 260799002878 sequence-specific DNA binding site [nucleotide binding]; other site 260799002879 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 260799002880 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 260799002881 amphipathic channel; other site 260799002882 Asn-Pro-Ala signature motifs; other site 260799002883 glycerol kinase; Provisional; Region: glpK; PRK00047 260799002884 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 260799002885 N- and C-terminal domain interface [polypeptide binding]; other site 260799002886 active site 260799002887 MgATP binding site [chemical binding]; other site 260799002888 catalytic site [active] 260799002889 metal binding site [ion binding]; metal-binding site 260799002890 glycerol binding site [chemical binding]; other site 260799002891 homotetramer interface [polypeptide binding]; other site 260799002892 homodimer interface [polypeptide binding]; other site 260799002893 FBP binding site [chemical binding]; other site 260799002894 protein IIAGlc interface [polypeptide binding]; other site 260799002895 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 260799002896 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 260799002897 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 260799002898 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 260799002899 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799002900 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 260799002901 DNA binding residues [nucleotide binding] 260799002902 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 260799002903 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 260799002904 Transcriptional regulators [Transcription]; Region: MarR; COG1846 260799002905 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 260799002906 DoxX-like family; Region: DoxX_2; pfam13564 260799002907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799002908 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799002909 putative substrate translocation pore; other site 260799002910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799002911 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799002912 putative substrate translocation pore; other site 260799002913 Putative integral membrane protein DUF46; Region: DUF46; cl17511 260799002914 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 260799002915 Part of AAA domain; Region: AAA_19; pfam13245 260799002916 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 260799002917 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 260799002918 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 260799002919 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 260799002920 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 260799002921 transcriptional regulator Hpr; Provisional; Region: PRK13777 260799002922 Transcriptional regulators [Transcription]; Region: MarR; COG1846 260799002923 YtxH-like protein; Region: YtxH; cl02079 260799002924 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 260799002925 HIT family signature motif; other site 260799002926 catalytic residue [active] 260799002927 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 260799002928 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 260799002929 Walker A/P-loop; other site 260799002930 ATP binding site [chemical binding]; other site 260799002931 Q-loop/lid; other site 260799002932 ABC transporter signature motif; other site 260799002933 Walker B; other site 260799002934 D-loop; other site 260799002935 H-loop/switch region; other site 260799002936 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 260799002937 EcsC protein family; Region: EcsC; pfam12787 260799002938 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799002939 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799002940 Bacterial PH domain; Region: bPH_2; cl01348 260799002941 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 260799002942 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 260799002943 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 260799002944 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 260799002945 DNA binding residues [nucleotide binding] 260799002946 drug binding residues [chemical binding]; other site 260799002947 dimer interface [polypeptide binding]; other site 260799002948 Bacterial PH domain; Region: bPH_2; cl01348 260799002949 Predicted membrane protein [Function unknown]; Region: COG3428 260799002950 Bacterial PH domain; Region: bPH_2; pfam03703 260799002951 Bacterial PH domain; Region: bPH_2; pfam03703 260799002952 Bacterial PH domain; Region: bPH_2; pfam03703 260799002953 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 260799002954 Transglycosylase; Region: Transgly; pfam00912 260799002955 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 260799002956 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 260799002957 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 260799002958 substrate binding site [chemical binding]; other site 260799002959 active site 260799002960 ferrochelatase; Provisional; Region: PRK12435 260799002961 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 260799002962 C-terminal domain interface [polypeptide binding]; other site 260799002963 active site 260799002964 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 260799002965 active site 260799002966 N-terminal domain interface [polypeptide binding]; other site 260799002967 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 260799002968 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 260799002969 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 260799002970 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 260799002971 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; cl19625 260799002972 Fn3 associated; Region: Fn3_assoc; pfam13287 260799002973 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 260799002974 generic binding surface II; other site 260799002975 generic binding surface I; other site 260799002976 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 260799002977 putative active site [active] 260799002978 putative catalytic site [active] 260799002979 putative Mg binding site IVb [ion binding]; other site 260799002980 putative phosphate binding site [ion binding]; other site 260799002981 putative DNA binding site [nucleotide binding]; other site 260799002982 putative Mg binding site IVa [ion binding]; other site 260799002983 Penicillinase repressor; Region: Penicillinase_R; pfam03965 260799002984 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 260799002985 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799002986 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799002987 Predicted membrane protein [Function unknown]; Region: COG1511 260799002988 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 260799002989 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 260799002990 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 260799002991 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 260799002992 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 260799002993 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 260799002994 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 260799002995 Bacterial PH domain; Region: bPH_3; pfam14470 260799002996 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799002997 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799002998 Coenzyme A binding pocket [chemical binding]; other site 260799002999 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 260799003000 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 260799003001 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 260799003002 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 260799003003 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 260799003004 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 260799003005 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 260799003006 acyl-activating enzyme (AAE) consensus motif; other site 260799003007 putative AMP binding site [chemical binding]; other site 260799003008 putative active site [active] 260799003009 putative CoA binding site [chemical binding]; other site 260799003010 rod-segment of the talin C-terminal domain; Region: talin-RS; cd12150 260799003011 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 260799003012 heme-binding site [chemical binding]; other site 260799003013 S-layer homology domain; Region: SLH; pfam00395 260799003014 S-layer homology domain; Region: SLH; pfam00395 260799003015 S-layer homology domain; Region: SLH; pfam00395 260799003016 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 260799003017 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 260799003018 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 260799003019 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 260799003020 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 260799003021 RHS Repeat; Region: RHS_repeat; pfam05593 260799003022 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 260799003023 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 260799003024 RHS protein; Region: RHS; pfam03527 260799003025 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 260799003026 Aureocin-like type II bacteriocin; Region: Bacteriocin_IIi; pfam11758 260799003027 Regulator of ribonuclease activity B; Region: RraB; pfam06877 260799003028 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 260799003029 RHS protein; Region: RHS; pfam03527 260799003030 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 260799003031 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 260799003032 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 260799003033 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 260799003034 Zn2+ binding site [ion binding]; other site 260799003035 Mg2+ binding site [ion binding]; other site 260799003036 Putative zinc-finger; Region: zf-HC2; pfam13490 260799003037 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 260799003038 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 260799003039 RNA polymerase sigma factor; Provisional; Region: PRK12541 260799003040 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799003041 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 260799003042 DNA binding residues [nucleotide binding] 260799003043 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 260799003044 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 260799003045 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 260799003046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 260799003047 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 260799003048 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799003049 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799003050 dimer interface [polypeptide binding]; other site 260799003051 phosphorylation site [posttranslational modification] 260799003052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799003053 ATP binding site [chemical binding]; other site 260799003054 Mg2+ binding site [ion binding]; other site 260799003055 G-X-G motif; other site 260799003056 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799003057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799003058 active site 260799003059 phosphorylation site [posttranslational modification] 260799003060 intermolecular recognition site; other site 260799003061 dimerization interface [polypeptide binding]; other site 260799003062 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799003063 DNA binding site [nucleotide binding] 260799003064 CAAX protease self-immunity; Region: Abi; pfam02517 260799003065 Peptidase family M48; Region: Peptidase_M48; pfam01435 260799003066 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 260799003067 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799003068 dimerization interface [polypeptide binding]; other site 260799003069 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 260799003070 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 260799003071 dimer interface [polypeptide binding]; other site 260799003072 putative CheW interface [polypeptide binding]; other site 260799003073 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 260799003074 EamA-like transporter family; Region: EamA; pfam00892 260799003075 EamA-like transporter family; Region: EamA; pfam00892 260799003076 S-layer homology domain; Region: SLH; pfam00395 260799003077 S-layer homology domain; Region: SLH; pfam00395 260799003078 S-layer homology domain; Region: SLH; pfam00395 260799003079 S-layer homology domain; Region: SLH; pfam00395 260799003080 S-layer homology domain; Region: SLH; pfam00395 260799003081 S-layer homology domain; Region: SLH; pfam00395 260799003082 S-layer homology domain; Region: SLH; pfam00395 260799003083 S-layer homology domain; Region: SLH; pfam00395 260799003084 S-layer homology domain; Region: SLH; pfam00395 260799003085 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 260799003086 active site 260799003087 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 260799003088 tetramer interface [polypeptide binding]; other site 260799003089 active site 260799003090 Mg2+/Mn2+ binding site [ion binding]; other site 260799003091 Phosphotransferase enzyme family; Region: APH; pfam01636 260799003092 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 260799003093 active site 260799003094 substrate binding site [chemical binding]; other site 260799003095 ATP binding site [chemical binding]; other site 260799003096 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 260799003097 DNA-binding site [nucleotide binding]; DNA binding site 260799003098 RNA-binding motif; other site 260799003099 ComK protein; Region: ComK; pfam06338 260799003100 Uncharacterized conserved protein [Function unknown]; Region: COG0398 260799003101 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 260799003102 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 260799003103 Catalytic site [active] 260799003104 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 260799003105 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 260799003106 AAA domain; Region: AAA_22; pfam13401 260799003107 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl19914 260799003108 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 260799003109 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 260799003110 Part of AAA domain; Region: AAA_19; pfam13245 260799003111 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 260799003112 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 260799003113 hypothetical protein; Provisional; Region: PRK07758 260799003114 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 260799003115 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 260799003116 Spore germination protein GerPC; Region: GerPC; pfam10737 260799003117 Spore germination GerPB; Region: GerPB; pfam10803 260799003118 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 260799003119 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 260799003120 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 260799003121 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 260799003122 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 260799003123 inhibitor-cofactor binding pocket; inhibition site 260799003124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799003125 catalytic residue [active] 260799003126 hypothetical protein; Provisional; Region: PRK13673 260799003127 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 260799003128 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 260799003129 active site 260799003130 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 260799003131 dimer interface [polypeptide binding]; other site 260799003132 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 260799003133 Ligand Binding Site [chemical binding]; other site 260799003134 Molecular Tunnel; other site 260799003135 ferrochelatase; Provisional; Region: PRK12435 260799003136 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 260799003137 C-terminal domain interface [polypeptide binding]; other site 260799003138 active site 260799003139 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 260799003140 active site 260799003141 N-terminal domain interface [polypeptide binding]; other site 260799003142 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 260799003143 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 260799003144 tetramer interface [polypeptide binding]; other site 260799003145 heme binding pocket [chemical binding]; other site 260799003146 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 260799003147 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 260799003148 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 260799003149 active site 260799003150 catalytic site [active] 260799003151 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799003152 non-specific DNA binding site [nucleotide binding]; other site 260799003153 salt bridge; other site 260799003154 sequence-specific DNA binding site [nucleotide binding]; other site 260799003155 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799003156 binding surface 260799003157 TPR motif; other site 260799003158 Tetratricopeptide repeat; Region: TPR_12; pfam13424 260799003159 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 260799003160 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 260799003161 S1 domain; Region: S1_2; pfam13509 260799003162 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 260799003163 SurA N-terminal domain; Region: SurA_N_3; cl07813 260799003164 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 260799003165 Uncharacterized conserved protein [Function unknown]; Region: COG1284 260799003166 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 260799003167 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 260799003168 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 260799003169 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 260799003170 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799003171 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 260799003172 active site 260799003173 motif I; other site 260799003174 motif II; other site 260799003175 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 260799003176 YjzC-like protein; Region: YjzC; pfam14168 260799003177 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 260799003178 Clp amino terminal domain; Region: Clp_N; pfam02861 260799003179 Clp amino terminal domain; Region: Clp_N; pfam02861 260799003180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799003181 Walker A motif; other site 260799003182 ATP binding site [chemical binding]; other site 260799003183 Walker B motif; other site 260799003184 arginine finger; other site 260799003185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799003186 Walker A motif; other site 260799003187 ATP binding site [chemical binding]; other site 260799003188 Walker B motif; other site 260799003189 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 260799003190 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 260799003191 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 260799003192 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 260799003193 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 260799003194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 260799003195 NAD(P) binding site [chemical binding]; other site 260799003196 active site 260799003197 ComZ; Region: ComZ; pfam10815 260799003198 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 260799003199 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 260799003200 dimer interface [polypeptide binding]; other site 260799003201 active site 260799003202 CoA binding pocket [chemical binding]; other site 260799003203 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 260799003204 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 260799003205 dimer interface [polypeptide binding]; other site 260799003206 active site 260799003207 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 260799003208 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 260799003209 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 260799003210 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 260799003211 active site 260799003212 HIGH motif; other site 260799003213 dimer interface [polypeptide binding]; other site 260799003214 KMSKS motif; other site 260799003215 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 260799003216 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 260799003217 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 260799003218 peptide binding site [polypeptide binding]; other site 260799003219 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 260799003220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799003221 dimer interface [polypeptide binding]; other site 260799003222 conserved gate region; other site 260799003223 putative PBP binding loops; other site 260799003224 ABC-ATPase subunit interface; other site 260799003225 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 260799003226 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 260799003227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799003228 dimer interface [polypeptide binding]; other site 260799003229 conserved gate region; other site 260799003230 putative PBP binding loops; other site 260799003231 ABC-ATPase subunit interface; other site 260799003232 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 260799003233 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 260799003234 Walker A/P-loop; other site 260799003235 ATP binding site [chemical binding]; other site 260799003236 Q-loop/lid; other site 260799003237 ABC transporter signature motif; other site 260799003238 Walker B; other site 260799003239 D-loop; other site 260799003240 H-loop/switch region; other site 260799003241 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 260799003242 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 260799003243 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 260799003244 Walker A/P-loop; other site 260799003245 ATP binding site [chemical binding]; other site 260799003246 Q-loop/lid; other site 260799003247 ABC transporter signature motif; other site 260799003248 Walker B; other site 260799003249 D-loop; other site 260799003250 H-loop/switch region; other site 260799003251 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 260799003252 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 260799003253 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 260799003254 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 260799003255 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 260799003256 peptide binding site [polypeptide binding]; other site 260799003257 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 260799003258 putative catalytic residues [active] 260799003259 thiol/disulfide switch; other site 260799003260 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 260799003261 adaptor protein; Provisional; Region: PRK02315 260799003262 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 260799003263 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 260799003264 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 260799003265 putative active site [active] 260799003266 catalytic site [active] 260799003267 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 260799003268 putative active site [active] 260799003269 catalytic site [active] 260799003270 Competence protein CoiA-like family; Region: CoiA; cl11541 260799003271 oligoendopeptidase F; Region: pepF; TIGR00181 260799003272 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 260799003273 active site 260799003274 Zn binding site [ion binding]; other site 260799003275 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 260799003276 catalytic residues [active] 260799003277 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 260799003278 apolar tunnel; other site 260799003279 heme binding site [chemical binding]; other site 260799003280 dimerization interface [polypeptide binding]; other site 260799003281 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 260799003282 putative active site [active] 260799003283 putative metal binding residues [ion binding]; other site 260799003284 signature motif; other site 260799003285 putative triphosphate binding site [ion binding]; other site 260799003286 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 260799003287 synthetase active site [active] 260799003288 NTP binding site [chemical binding]; other site 260799003289 metal binding site [ion binding]; metal-binding site 260799003290 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 260799003291 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 260799003292 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 260799003293 active site 260799003294 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 260799003295 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 260799003296 active site 260799003297 metal binding site [ion binding]; metal-binding site 260799003298 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 260799003299 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 260799003300 active site 260799003301 Methyltransferase domain; Region: Methyltransf_31; pfam13847 260799003302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799003303 S-adenosylmethionine binding site [chemical binding]; other site 260799003304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 260799003305 exosporium leader peptide; Region: exospor_lead; TIGR03720 260799003306 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 260799003307 putative metal binding site; other site 260799003308 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799003309 binding surface 260799003310 TPR motif; other site 260799003311 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799003312 binding surface 260799003313 TPR motif; other site 260799003314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799003315 S-adenosylmethionine binding site [chemical binding]; other site 260799003316 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 260799003317 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 260799003318 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 260799003319 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 260799003320 active site 260799003321 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 260799003322 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 260799003323 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 260799003324 NAD binding site [chemical binding]; other site 260799003325 substrate binding site [chemical binding]; other site 260799003326 homodimer interface [polypeptide binding]; other site 260799003327 active site 260799003328 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 260799003329 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 260799003330 NADP binding site [chemical binding]; other site 260799003331 active site 260799003332 putative substrate binding site [chemical binding]; other site 260799003333 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 260799003334 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 260799003335 NAD binding site [chemical binding]; other site 260799003336 homotetramer interface [polypeptide binding]; other site 260799003337 homodimer interface [polypeptide binding]; other site 260799003338 substrate binding site [chemical binding]; other site 260799003339 active site 260799003340 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 260799003341 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 260799003342 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 260799003343 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 260799003344 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 260799003345 Part of AAA domain; Region: AAA_19; pfam13245 260799003346 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 260799003347 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799003348 Coenzyme A binding pocket [chemical binding]; other site 260799003349 hypothetical protein; Provisional; Region: PRK13679 260799003350 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 260799003351 Putative esterase; Region: Esterase; pfam00756 260799003352 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 260799003353 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 260799003354 EamA-like transporter family; Region: EamA; pfam00892 260799003355 EamA-like transporter family; Region: EamA; pfam00892 260799003356 Bacterial PH domain; Region: bPH_4; pfam06713 260799003357 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 260799003358 Pectate lyase; Region: Pectate_lyase; pfam03211 260799003359 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 260799003360 Na binding site [ion binding]; other site 260799003361 anthranilate synthase component I; Provisional; Region: PRK13570 260799003362 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 260799003363 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 260799003364 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 260799003365 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 260799003366 glutamine binding [chemical binding]; other site 260799003367 catalytic triad [active] 260799003368 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 260799003369 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 260799003370 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 260799003371 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 260799003372 active site 260799003373 ribulose/triose binding site [chemical binding]; other site 260799003374 phosphate binding site [ion binding]; other site 260799003375 substrate (anthranilate) binding pocket [chemical binding]; other site 260799003376 product (indole) binding pocket [chemical binding]; other site 260799003377 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 260799003378 active site 260799003379 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 260799003380 cysteine synthase; Region: PLN02565 260799003381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799003382 catalytic residue [active] 260799003383 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 260799003384 substrate binding site [chemical binding]; other site 260799003385 active site 260799003386 catalytic residues [active] 260799003387 heterodimer interface [polypeptide binding]; other site 260799003388 Protein of unknown function (DUF4029); Region: DUF4029; pfam13221 260799003389 L-lactate permease; Region: Lactate_perm; cl00701 260799003390 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 260799003391 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 260799003392 Double zinc ribbon; Region: DZR; pfam12773 260799003393 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 260799003394 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 260799003395 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 260799003396 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 260799003397 Predicted acetyltransferase [General function prediction only]; Region: COG5628 260799003398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799003399 Coenzyme A binding pocket [chemical binding]; other site 260799003400 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 260799003401 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 260799003402 NADPH bind site [chemical binding]; other site 260799003403 putative FMN binding site [chemical binding]; other site 260799003404 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 260799003405 putative FMN binding site [chemical binding]; other site 260799003406 NADPH bind site [chemical binding]; other site 260799003407 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 260799003408 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 260799003409 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 260799003410 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 260799003411 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 260799003412 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 260799003413 E3 interaction surface; other site 260799003414 lipoyl attachment site [posttranslational modification]; other site 260799003415 e3 binding domain; Region: E3_binding; pfam02817 260799003416 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 260799003417 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 260799003418 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 260799003419 TPP-binding site [chemical binding]; other site 260799003420 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 260799003421 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799003422 salt bridge; other site 260799003423 non-specific DNA binding site [nucleotide binding]; other site 260799003424 sequence-specific DNA binding site [nucleotide binding]; other site 260799003425 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 260799003426 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 260799003427 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 260799003428 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 260799003429 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 260799003430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799003431 S-adenosylmethionine binding site [chemical binding]; other site 260799003432 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 260799003433 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 260799003434 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 260799003435 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 260799003436 Catalytic site [active] 260799003437 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 260799003438 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 260799003439 Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389 260799003440 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 260799003441 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799003442 non-specific DNA binding site [nucleotide binding]; other site 260799003443 salt bridge; other site 260799003444 sequence-specific DNA binding site [nucleotide binding]; other site 260799003445 Anti-repressor SinI; Region: SinI; pfam08671 260799003446 Anti-repressor SinI; Region: SinI; pfam08671 260799003447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 260799003448 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 260799003449 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 260799003450 NAD(P) binding site [chemical binding]; other site 260799003451 catalytic residues [active] 260799003452 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 260799003453 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 260799003454 Walker A/P-loop; other site 260799003455 ATP binding site [chemical binding]; other site 260799003456 Q-loop/lid; other site 260799003457 ABC transporter signature motif; other site 260799003458 Walker B; other site 260799003459 D-loop; other site 260799003460 H-loop/switch region; other site 260799003461 TOBE domain; Region: TOBE_2; pfam08402 260799003462 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 260799003463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799003464 dimer interface [polypeptide binding]; other site 260799003465 conserved gate region; other site 260799003466 putative PBP binding loops; other site 260799003467 ABC-ATPase subunit interface; other site 260799003468 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 260799003469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799003470 dimer interface [polypeptide binding]; other site 260799003471 conserved gate region; other site 260799003472 putative PBP binding loops; other site 260799003473 ABC-ATPase subunit interface; other site 260799003474 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 260799003475 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 260799003476 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 260799003477 active site 260799003478 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 260799003479 MMPL family; Region: MMPL; cl14618 260799003480 MMPL family; Region: MMPL; cl14618 260799003481 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 260799003482 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 260799003483 active site 260799003484 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 260799003485 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 260799003486 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 260799003487 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 260799003488 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 260799003489 Cysteine-rich domain; Region: CCG; pfam02754 260799003490 Cysteine-rich domain; Region: CCG; pfam02754 260799003491 FAD binding domain; Region: FAD_binding_4; pfam01565 260799003492 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 260799003493 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 260799003494 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 260799003495 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 260799003496 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 260799003497 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 260799003498 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 260799003499 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 260799003500 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799003501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799003502 active site 260799003503 phosphorylation site [posttranslational modification] 260799003504 intermolecular recognition site; other site 260799003505 dimerization interface [polypeptide binding]; other site 260799003506 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799003507 DNA binding site [nucleotide binding] 260799003508 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 260799003509 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799003510 dimerization interface [polypeptide binding]; other site 260799003511 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799003512 dimer interface [polypeptide binding]; other site 260799003513 phosphorylation site [posttranslational modification] 260799003514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799003515 ATP binding site [chemical binding]; other site 260799003516 Mg2+ binding site [ion binding]; other site 260799003517 G-X-G motif; other site 260799003518 Transcriptional regulators [Transcription]; Region: FadR; COG2186 260799003519 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 260799003520 DNA-binding site [nucleotide binding]; DNA binding site 260799003521 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 260799003522 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 260799003523 Cysteine-rich domain; Region: CCG; pfam02754 260799003524 Cysteine-rich domain; Region: CCG; pfam02754 260799003525 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 260799003526 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 260799003527 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 260799003528 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 260799003529 Uncharacterized conserved protein [Function unknown]; Region: COG1556 260799003530 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 260799003531 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 260799003532 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 260799003533 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 260799003534 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 260799003535 Cation transport protein; Region: TrkH; cl17365 260799003536 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 260799003537 Cation transport protein; Region: TrkH; cl17365 260799003538 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 260799003539 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 260799003540 dimer interaction site [polypeptide binding]; other site 260799003541 substrate-binding tunnel; other site 260799003542 active site 260799003543 catalytic site [active] 260799003544 substrate binding site [chemical binding]; other site 260799003545 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 260799003546 poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719 260799003547 Transcriptional regulators [Transcription]; Region: MarR; COG1846 260799003548 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 260799003549 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 260799003550 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 260799003551 NAD(P) binding site [chemical binding]; other site 260799003552 active site 260799003553 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 260799003554 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 260799003555 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl19415 260799003556 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 260799003557 FAD dependent oxidoreductase; Region: DAO; pfam01266 260799003558 Cation transport protein; Region: TrkH; cl17365 260799003559 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 260799003560 Cation transport protein; Region: TrkH; pfam02386 260799003561 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 260799003562 putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261 260799003563 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 260799003564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799003565 dimer interface [polypeptide binding]; other site 260799003566 conserved gate region; other site 260799003567 putative PBP binding loops; other site 260799003568 ABC-ATPase subunit interface; other site 260799003569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799003570 dimer interface [polypeptide binding]; other site 260799003571 conserved gate region; other site 260799003572 putative PBP binding loops; other site 260799003573 ABC-ATPase subunit interface; other site 260799003574 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 260799003575 phosphonoacetaldehyde hydrolase; Region: phosphonatase; TIGR01422 260799003576 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799003577 motif II; other site 260799003578 2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326 260799003579 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 260799003580 catalytic residue [active] 260799003581 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 260799003582 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 260799003583 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 260799003584 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 260799003585 FOG: CBS domain [General function prediction only]; Region: COG0517 260799003586 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 260799003587 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 260799003588 NodB motif; other site 260799003589 putative active site [active] 260799003590 putative catalytic site [active] 260799003591 Zn binding site [ion binding]; other site 260799003592 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 260799003593 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 260799003594 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799003595 dimer interface [polypeptide binding]; other site 260799003596 phosphorylation site [posttranslational modification] 260799003597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799003598 ATP binding site [chemical binding]; other site 260799003599 Mg2+ binding site [ion binding]; other site 260799003600 G-X-G motif; other site 260799003601 Transcriptional regulators [Transcription]; Region: MarR; COG1846 260799003602 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 260799003603 dimerization interface [polypeptide binding]; other site 260799003604 putative DNA binding site [nucleotide binding]; other site 260799003605 putative Zn2+ binding site [ion binding]; other site 260799003606 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 260799003607 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 260799003608 active site 260799003609 Zn binding site [ion binding]; other site 260799003610 DinB superfamily; Region: DinB_2; pfam12867 260799003611 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 260799003612 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799003613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799003614 dimer interface [polypeptide binding]; other site 260799003615 phosphorylation site [posttranslational modification] 260799003616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799003617 ATP binding site [chemical binding]; other site 260799003618 Mg2+ binding site [ion binding]; other site 260799003619 G-X-G motif; other site 260799003620 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 260799003621 Ligand Binding Site [chemical binding]; other site 260799003622 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 260799003623 active site 260799003624 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 260799003625 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 260799003626 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 260799003627 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 260799003628 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 260799003629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799003630 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 260799003631 Coenzyme A binding pocket [chemical binding]; other site 260799003632 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 260799003633 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 260799003634 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 260799003635 N-terminal catalytic domain of GIY-YIG intron endonuclease I-TevI, I-BmoI, I-BanI, I-BthII and similar proteins; Region: GIY-YIG_HE_I-TevI_like; cd10437 260799003636 group I intron endonuclease; Region: grpIintron_endo; TIGR01453 260799003637 GIY-YIG motif/motif A; other site 260799003638 putative active site [active] 260799003639 catalytic site [active] 260799003640 putative metal binding site [ion binding]; other site 260799003641 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cd00283 260799003642 DNA binding site [nucleotide binding] 260799003643 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 260799003644 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 260799003645 dimer interface [polypeptide binding]; other site 260799003646 putative radical transfer pathway; other site 260799003647 diiron center [ion binding]; other site 260799003648 tyrosyl radical; other site 260799003649 Predicted transcriptional regulators [Transcription]; Region: COG1725 260799003650 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 260799003651 DNA-binding site [nucleotide binding]; DNA binding site 260799003652 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 260799003653 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 260799003654 Walker A/P-loop; other site 260799003655 ATP binding site [chemical binding]; other site 260799003656 Q-loop/lid; other site 260799003657 ABC transporter signature motif; other site 260799003658 Walker B; other site 260799003659 D-loop; other site 260799003660 H-loop/switch region; other site 260799003661 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 260799003662 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 260799003663 Walker A/P-loop; other site 260799003664 ATP binding site [chemical binding]; other site 260799003665 Q-loop/lid; other site 260799003666 ABC transporter signature motif; other site 260799003667 Walker B; other site 260799003668 D-loop; other site 260799003669 H-loop/switch region; other site 260799003670 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 260799003671 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 260799003672 CAAX protease self-immunity; Region: Abi; pfam02517 260799003673 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 260799003674 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 260799003675 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 260799003676 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799003677 putative DNA binding site [nucleotide binding]; other site 260799003678 putative Zn2+ binding site [ion binding]; other site 260799003679 AsnC family; Region: AsnC_trans_reg; pfam01037 260799003680 Uncharacterized conserved protein [Function unknown]; Region: COG2128 260799003681 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 260799003682 catalytic triad [active] 260799003683 conserved cis-peptide bond; other site 260799003684 SseB protein N-terminal domain; Region: SseB; pfam07179 260799003685 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 260799003686 dimer interface [polypeptide binding]; other site 260799003687 catalytic triad [active] 260799003688 Nitronate monooxygenase; Region: NMO; pfam03060 260799003689 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 260799003690 FMN binding site [chemical binding]; other site 260799003691 substrate binding site [chemical binding]; other site 260799003692 putative catalytic residue [active] 260799003693 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 260799003694 DltD N-terminal region; Region: DltD_N; pfam04915 260799003695 DltD central region; Region: DltD_M; pfam04918 260799003696 DltD C-terminal region; Region: DltD_C; pfam04914 260799003697 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 260799003698 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 260799003699 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 260799003700 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 260799003701 acyl-activating enzyme (AAE) consensus motif; other site 260799003702 AMP binding site [chemical binding]; other site 260799003703 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 260799003704 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 260799003705 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 260799003706 metal binding site [ion binding]; metal-binding site 260799003707 dimer interface [polypeptide binding]; other site 260799003708 flavodoxin; Provisional; Region: PRK06756 260799003709 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 260799003710 Phosphotransferase enzyme family; Region: APH; pfam01636 260799003711 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 260799003712 active site 260799003713 substrate binding site [chemical binding]; other site 260799003714 ATP binding site [chemical binding]; other site 260799003715 multidrug efflux protein; Reviewed; Region: PRK01766 260799003716 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 260799003717 cation binding site [ion binding]; other site 260799003718 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 260799003719 Thioredoxin; Region: Thioredoxin_9; pfam14595 260799003720 Regulatory protein YrvL; Region: YrvL; pfam14184 260799003721 Transcriptional regulators [Transcription]; Region: MarR; COG1846 260799003722 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 260799003723 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 260799003724 Cation transport protein; Region: TrkH; cl17365 260799003725 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 260799003726 Cation transport protein; Region: TrkH; pfam02386 260799003727 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 260799003728 hypothetical protein; Provisional; Region: PRK03094 260799003729 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 260799003730 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 260799003731 homodimer interface [polypeptide binding]; other site 260799003732 substrate-cofactor binding pocket; other site 260799003733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799003734 catalytic residue [active] 260799003735 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 260799003736 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 260799003737 PYR/PP interface [polypeptide binding]; other site 260799003738 dimer interface [polypeptide binding]; other site 260799003739 TPP binding site [chemical binding]; other site 260799003740 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 260799003741 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 260799003742 TPP-binding site [chemical binding]; other site 260799003743 dimer interface [polypeptide binding]; other site 260799003744 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 260799003745 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 260799003746 putative valine binding site [chemical binding]; other site 260799003747 dimer interface [polypeptide binding]; other site 260799003748 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 260799003749 ketol-acid reductoisomerase; Provisional; Region: PRK05479 260799003750 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 260799003751 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 260799003752 2-isopropylmalate synthase; Validated; Region: PRK00915 260799003753 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 260799003754 active site 260799003755 catalytic residues [active] 260799003756 metal binding site [ion binding]; metal-binding site 260799003757 LeuA allosteric (dimerization) domain; Region: LeuA_dimer; pfam08502 260799003758 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 260799003759 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 260799003760 substrate binding site [chemical binding]; other site 260799003761 ligand binding site [chemical binding]; other site 260799003762 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 260799003763 substrate binding site [chemical binding]; other site 260799003764 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 260799003765 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 260799003766 dimer interface [polypeptide binding]; other site 260799003767 motif 1; other site 260799003768 active site 260799003769 motif 2; other site 260799003770 motif 3; other site 260799003771 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 260799003772 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 260799003773 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 260799003774 histidinol dehydrogenase; Region: hisD; TIGR00069 260799003775 NAD binding site [chemical binding]; other site 260799003776 dimerization interface [polypeptide binding]; other site 260799003777 product binding site; other site 260799003778 substrate binding site [chemical binding]; other site 260799003779 zinc binding site [ion binding]; other site 260799003780 catalytic residues [active] 260799003781 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 260799003782 putative active site pocket [active] 260799003783 4-fold oligomerization interface [polypeptide binding]; other site 260799003784 metal binding residues [ion binding]; metal-binding site 260799003785 3-fold/trimer interface [polypeptide binding]; other site 260799003786 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 260799003787 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 260799003788 putative active site [active] 260799003789 oxyanion strand; other site 260799003790 catalytic triad [active] 260799003791 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 260799003792 catalytic residues [active] 260799003793 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 260799003794 substrate binding site [chemical binding]; other site 260799003795 glutamase interaction surface [polypeptide binding]; other site 260799003796 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 260799003797 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 260799003798 metal binding site [ion binding]; metal-binding site 260799003799 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 260799003800 dimer interface [polypeptide binding]; other site 260799003801 active site 260799003802 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 260799003803 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 260799003804 putative ligand binding site [chemical binding]; other site 260799003805 putative NAD binding site [chemical binding]; other site 260799003806 catalytic site [active] 260799003807 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 260799003808 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 260799003809 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 260799003810 Sulfatase; Region: Sulfatase; pfam00884 260799003811 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 260799003812 diaminopimelate decarboxylase; Region: lysA; TIGR01048 260799003813 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 260799003814 active site 260799003815 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 260799003816 substrate binding site [chemical binding]; other site 260799003817 catalytic residues [active] 260799003818 dimer interface [polypeptide binding]; other site 260799003819 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 260799003820 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 260799003821 Active Sites [active] 260799003822 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 260799003823 ATP-sulfurylase; Region: ATPS; cd00517 260799003824 active site 260799003825 HXXH motif; other site 260799003826 flexible loop; other site 260799003827 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 260799003828 ligand-binding site [chemical binding]; other site 260799003829 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 260799003830 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 260799003831 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 260799003832 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 260799003833 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 260799003834 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 260799003835 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 260799003836 active site 260799003837 SAM binding site [chemical binding]; other site 260799003838 homodimer interface [polypeptide binding]; other site 260799003839 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 260799003840 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 260799003841 putative active site [active] 260799003842 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 260799003843 putative active site [active] 260799003844 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 260799003845 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 260799003846 Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824 260799003847 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 260799003848 Na2 binding site [ion binding]; other site 260799003849 putative substrate binding site 1 [chemical binding]; other site 260799003850 Na binding site 1 [ion binding]; other site 260799003851 putative substrate binding site 2 [chemical binding]; other site 260799003852 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 260799003853 Protein of unknown function (DUF342); Region: DUF342; cl19219 260799003854 Peptidase family M23; Region: Peptidase_M23; pfam01551 260799003855 Protein of unknown function (DUF402); Region: DUF402; cl00979 260799003856 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 260799003857 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 260799003858 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 260799003859 Uncharacterized conserved protein [Function unknown]; Region: COG2966 260799003860 PspA/IM30 family; Region: PspA_IM30; pfam04012 260799003861 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 260799003862 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 260799003863 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 260799003864 Histidine kinase; Region: HisKA_3; pfam07730 260799003865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799003866 ATP binding site [chemical binding]; other site 260799003867 Mg2+ binding site [ion binding]; other site 260799003868 G-X-G motif; other site 260799003869 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 260799003870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799003871 active site 260799003872 phosphorylation site [posttranslational modification] 260799003873 intermolecular recognition site; other site 260799003874 dimerization interface [polypeptide binding]; other site 260799003875 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 260799003876 DNA binding residues [nucleotide binding] 260799003877 dimerization interface [polypeptide binding]; other site 260799003878 Protein of unknown function (DUF3992); Region: DUF3922; pfam13059 260799003879 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 260799003880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799003881 S-adenosylmethionine binding site [chemical binding]; other site 260799003882 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 260799003883 Peptidase family M50; Region: Peptidase_M50; pfam02163 260799003884 active site 260799003885 putative substrate binding region [chemical binding]; other site 260799003886 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 260799003887 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 260799003888 heme-binding site [chemical binding]; other site 260799003889 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 260799003890 FAD binding pocket [chemical binding]; other site 260799003891 FAD binding motif [chemical binding]; other site 260799003892 phosphate binding motif [ion binding]; other site 260799003893 beta-alpha-beta structure motif; other site 260799003894 NAD binding pocket [chemical binding]; other site 260799003895 Heme binding pocket [chemical binding]; other site 260799003896 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 260799003897 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 260799003898 ligand binding site [chemical binding]; other site 260799003899 flexible hinge region; other site 260799003900 non-specific DNA interactions [nucleotide binding]; other site 260799003901 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 260799003902 DNA binding site [nucleotide binding] 260799003903 sequence specific DNA binding site [nucleotide binding]; other site 260799003904 putative cAMP binding site [chemical binding]; other site 260799003905 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 260799003906 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 260799003907 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 260799003908 TIGR00153 family protein; Region: TIGR00153 260799003909 Transglycosylase; Region: Transgly; pfam00912 260799003910 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 260799003911 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 260799003912 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 260799003913 PAS domain; Region: PAS_9; pfam13426 260799003914 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 260799003915 putative active site [active] 260799003916 heme pocket [chemical binding]; other site 260799003917 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799003918 dimer interface [polypeptide binding]; other site 260799003919 phosphorylation site [posttranslational modification] 260799003920 Protein of unknown function DUF72; Region: DUF72; pfam01904 260799003921 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 260799003922 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 260799003923 active site 260799003924 DNA binding site [nucleotide binding] 260799003925 Int/Topo IB signature motif; other site 260799003926 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 260799003927 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799003928 dimerization interface [polypeptide binding]; other site 260799003929 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799003930 dimer interface [polypeptide binding]; other site 260799003931 phosphorylation site [posttranslational modification] 260799003932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799003933 ATP binding site [chemical binding]; other site 260799003934 Mg2+ binding site [ion binding]; other site 260799003935 G-X-G motif; other site 260799003936 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 260799003937 Probable transposase; Region: OrfB_IS605; pfam01385 260799003938 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 260799003939 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 260799003940 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 260799003941 Predicted integral membrane protein [Function unknown]; Region: COG0392 260799003942 Uncharacterized conserved protein [Function unknown]; Region: COG2898 260799003943 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 260799003944 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 260799003945 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 260799003946 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 260799003947 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 260799003948 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 260799003949 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 260799003950 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 260799003951 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 260799003952 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 260799003953 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 260799003954 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 260799003955 RNA binding surface [nucleotide binding]; other site 260799003956 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 260799003957 active site 260799003958 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 260799003959 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 260799003960 catalytic residues [active] 260799003961 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 260799003962 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 260799003963 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799003964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799003965 active site 260799003966 phosphorylation site [posttranslational modification] 260799003967 intermolecular recognition site; other site 260799003968 dimerization interface [polypeptide binding]; other site 260799003969 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799003970 DNA binding site [nucleotide binding] 260799003971 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 260799003972 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799003973 dimerization interface [polypeptide binding]; other site 260799003974 PAS domain; Region: PAS; smart00091 260799003975 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799003976 dimer interface [polypeptide binding]; other site 260799003977 phosphorylation site [posttranslational modification] 260799003978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799003979 ATP binding site [chemical binding]; other site 260799003980 Mg2+ binding site [ion binding]; other site 260799003981 G-X-G motif; other site 260799003982 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 260799003983 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 260799003984 Peptidase family M23; Region: Peptidase_M23; pfam01551 260799003985 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 260799003986 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 260799003987 Predicted membrane protein [Function unknown]; Region: COG3601 260799003988 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 260799003989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 260799003990 Helix-turn-helix domain; Region: HTH_40; pfam14493 260799003991 DEAD-like helicases superfamily; Region: DEXDc; smart00487 260799003992 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 260799003993 ATP binding site [chemical binding]; other site 260799003994 putative Mg++ binding site [ion binding]; other site 260799003995 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 260799003996 nucleotide binding region [chemical binding]; other site 260799003997 ATP-binding site [chemical binding]; other site 260799003998 CAAX protease self-immunity; Region: Abi; pfam02517 260799003999 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 260799004000 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 260799004001 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 260799004002 DNA binding residues [nucleotide binding] 260799004003 B12 binding domain; Region: B12-binding_2; pfam02607 260799004004 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 260799004005 adaptor protein; Provisional; Region: PRK02899 260799004006 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 260799004007 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 260799004008 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 260799004009 NAD(P) binding site [chemical binding]; other site 260799004010 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 260799004011 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 260799004012 amidase catalytic site [active] 260799004013 Zn binding residues [ion binding]; other site 260799004014 substrate binding site [chemical binding]; other site 260799004015 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 260799004016 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 260799004017 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 260799004018 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 260799004019 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 260799004020 active site 260799004021 homotetramer interface [polypeptide binding]; other site 260799004022 homodimer interface [polypeptide binding]; other site 260799004023 cytidylate kinase; Provisional; Region: cmk; PRK00023 260799004024 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 260799004025 AAA domain; Region: AAA_18; pfam13238 260799004026 CMP-binding site; other site 260799004027 The sites determining sugar specificity; other site 260799004028 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 260799004029 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 260799004030 RNA binding site [nucleotide binding]; other site 260799004031 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 260799004032 RNA binding site [nucleotide binding]; other site 260799004033 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 260799004034 RNA binding site [nucleotide binding]; other site 260799004035 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 260799004036 RNA binding site [nucleotide binding]; other site 260799004037 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 260799004038 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 260799004039 homotetramer interface [polypeptide binding]; other site 260799004040 FMN binding site [chemical binding]; other site 260799004041 homodimer contacts [polypeptide binding]; other site 260799004042 putative active site [active] 260799004043 putative substrate binding site [chemical binding]; other site 260799004044 YpzI-like protein; Region: YpzI; pfam14140 260799004045 YIEGIA protein; Region: YIEGIA; pfam14045 260799004046 GTP-binding protein Der; Reviewed; Region: PRK00093 260799004047 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 260799004048 G1 box; other site 260799004049 GTP/Mg2+ binding site [chemical binding]; other site 260799004050 Switch I region; other site 260799004051 G2 box; other site 260799004052 Switch II region; other site 260799004053 G3 box; other site 260799004054 G4 box; other site 260799004055 G5 box; other site 260799004056 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 260799004057 G1 box; other site 260799004058 GTP/Mg2+ binding site [chemical binding]; other site 260799004059 Switch I region; other site 260799004060 G2 box; other site 260799004061 G3 box; other site 260799004062 Switch II region; other site 260799004063 G4 box; other site 260799004064 G5 box; other site 260799004065 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 260799004066 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 260799004067 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 260799004068 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 260799004069 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 260799004070 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 260799004071 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 260799004072 histone-like DNA-binding protein HU; Region: HU; cd13831 260799004073 dimer interface [polypeptide binding]; other site 260799004074 DNA binding site [nucleotide binding] 260799004075 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 260799004076 homodecamer interface [polypeptide binding]; other site 260799004077 active site 260799004078 putative catalytic site residues [active] 260799004079 zinc binding site [ion binding]; other site 260799004080 GTP-CH-I/GFRP interaction surface; other site 260799004081 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 260799004082 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 260799004083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799004084 S-adenosylmethionine binding site [chemical binding]; other site 260799004085 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 260799004086 substrate binding pocket [chemical binding]; other site 260799004087 chain length determination region; other site 260799004088 substrate-Mg2+ binding site; other site 260799004089 catalytic residues [active] 260799004090 aspartate-rich region 1; other site 260799004091 active site lid residues [active] 260799004092 aspartate-rich region 2; other site 260799004093 Nucleoside diphosphate kinase; Region: NDK; pfam00334 260799004094 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 260799004095 active site 260799004096 multimer interface [polypeptide binding]; other site 260799004097 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 260799004098 Tetramer interface [polypeptide binding]; other site 260799004099 active site 260799004100 FMN-binding site [chemical binding]; other site 260799004101 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 260799004102 active site 260799004103 dimer interface [polypeptide binding]; other site 260799004104 metal binding site [ion binding]; metal-binding site 260799004105 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 260799004106 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 260799004107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799004108 homodimer interface [polypeptide binding]; other site 260799004109 catalytic residue [active] 260799004110 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 260799004111 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799004112 binding surface 260799004113 TPR motif; other site 260799004114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799004115 binding surface 260799004116 TPR motif; other site 260799004117 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799004118 binding surface 260799004119 TPR motif; other site 260799004120 hypothetical protein; Provisional; Region: PRK03636 260799004121 UPF0302 domain; Region: UPF0302; pfam08864 260799004122 IDEAL domain; Region: IDEAL; pfam08858 260799004123 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 260799004124 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 260799004125 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 260799004126 iron-sulfur cluster [ion binding]; other site 260799004127 [2Fe-2S] cluster binding site [ion binding]; other site 260799004128 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 260799004129 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 260799004130 interchain domain interface [polypeptide binding]; other site 260799004131 intrachain domain interface; other site 260799004132 heme bH binding site [chemical binding]; other site 260799004133 Qi binding site; other site 260799004134 heme bL binding site [chemical binding]; other site 260799004135 Qo binding site; other site 260799004136 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 260799004137 interchain domain interface [polypeptide binding]; other site 260799004138 intrachain domain interface; other site 260799004139 Qi binding site; other site 260799004140 Qo binding site; other site 260799004141 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 260799004142 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 260799004143 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 260799004144 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 260799004145 sporulation protein YpjB; Region: spore_ypjB; TIGR02878 260799004146 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 260799004147 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 260799004148 active site 260799004149 Fe-S cluster binding site [ion binding]; other site 260799004150 Uncharacterized conserved protein [Function unknown]; Region: COG1284 260799004151 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 260799004152 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 260799004153 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 260799004154 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 260799004155 homodimer interface [polypeptide binding]; other site 260799004156 metal binding site [ion binding]; metal-binding site 260799004157 dihydrodipicolinate reductase; Provisional; Region: PRK00048 260799004158 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 260799004159 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 260799004160 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 260799004161 active site 260799004162 dimer interfaces [polypeptide binding]; other site 260799004163 catalytic residues [active] 260799004164 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 260799004165 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 260799004166 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 260799004167 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 260799004168 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 260799004169 active site 260799004170 NTP binding site [chemical binding]; other site 260799004171 metal binding triad [ion binding]; metal-binding site 260799004172 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 260799004173 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 260799004174 Biotin operon repressor [Transcription]; Region: BirA; COG1654 260799004175 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 260799004176 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 260799004177 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 260799004178 Uncharacterized subfamiy of Cupredoxin; Region: Cupredoxin_like_3; cd04203 260799004179 Type 1 (T1) Cu binding site [ion binding]; other site 260799004180 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 260799004181 oligomerization interface [polypeptide binding]; other site 260799004182 active site 260799004183 metal binding site [ion binding]; metal-binding site 260799004184 Pantoate-beta-alanine ligase; Region: PanC; cd00560 260799004185 active site 260799004186 ATP-binding site [chemical binding]; other site 260799004187 pantoate-binding site; other site 260799004188 HXXH motif; other site 260799004189 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 260799004190 tetramerization interface [polypeptide binding]; other site 260799004191 active site 260799004192 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 260799004193 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 260799004194 active site 260799004195 catalytic site [active] 260799004196 substrate binding site [chemical binding]; other site 260799004197 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 260799004198 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 260799004199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 260799004200 aspartate aminotransferase; Provisional; Region: PRK05764 260799004201 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 260799004202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799004203 homodimer interface [polypeptide binding]; other site 260799004204 catalytic residue [active] 260799004205 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 260799004206 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 260799004207 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 260799004208 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 260799004209 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 260799004210 minor groove reading motif; other site 260799004211 helix-hairpin-helix signature motif; other site 260799004212 substrate binding pocket [chemical binding]; other site 260799004213 active site 260799004214 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 260799004215 Transglycosylase; Region: Transgly; pfam00912 260799004216 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 260799004217 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 260799004218 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 260799004219 Interdomain contacts; other site 260799004220 Cytokine receptor motif; other site 260799004221 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 260799004222 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 260799004223 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 260799004224 YppF-like protein; Region: YppF; pfam14178 260799004225 YppG-like protein; Region: YppG; pfam14179 260799004226 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 260799004227 hypothetical protein; Provisional; Region: PRK13660 260799004228 cell division protein GpsB; Provisional; Region: PRK14127; cl19517 260799004229 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 260799004230 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 260799004231 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 260799004232 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 260799004233 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 260799004234 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 260799004235 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 260799004236 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 260799004237 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 260799004238 active site 260799004239 Zn binding site [ion binding]; other site 260799004240 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799004241 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799004242 Coenzyme A binding pocket [chemical binding]; other site 260799004243 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 260799004244 Phosphotransferase enzyme family; Region: APH; pfam01636 260799004245 putative active site [active] 260799004246 putative substrate binding site [chemical binding]; other site 260799004247 ATP binding site [chemical binding]; other site 260799004248 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 260799004249 active site 260799004250 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 260799004251 active site 260799004252 Sulfate transporter family; Region: Sulfate_transp; cl19250 260799004253 xanthine permease; Region: pbuX; TIGR03173 260799004254 Predicted membrane protein [Function unknown]; Region: COG2311 260799004255 Protein of unknown function (DUF418); Region: DUF418; pfam04235 260799004256 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 260799004257 G1 box; other site 260799004258 GTP/Mg2+ binding site [chemical binding]; other site 260799004259 G2 box; other site 260799004260 Switch I region; other site 260799004261 G3 box; other site 260799004262 Switch II region; other site 260799004263 G4 box; other site 260799004264 G5 box; other site 260799004265 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 260799004266 G1 box; other site 260799004267 GTP/Mg2+ binding site [chemical binding]; other site 260799004268 G2 box; other site 260799004269 Switch I region; other site 260799004270 G3 box; other site 260799004271 Switch II region; other site 260799004272 G4 box; other site 260799004273 G5 box; other site 260799004274 Protein of unknown function (DUF3931); Region: DUF3931; pfam13082 260799004275 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799004276 Coenzyme A binding pocket [chemical binding]; other site 260799004277 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 260799004278 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 260799004279 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 260799004280 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 260799004281 active site residue [active] 260799004282 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 260799004283 active site residue [active] 260799004284 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 260799004285 Predicted membrane protein [Function unknown]; Region: COG3766 260799004286 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 260799004287 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 260799004288 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 260799004289 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 260799004290 5'-3' exonuclease; Region: 53EXOc; smart00475 260799004291 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 260799004292 active site 260799004293 metal binding site 1 [ion binding]; metal-binding site 260799004294 putative 5' ssDNA interaction site; other site 260799004295 metal binding site 3; metal-binding site 260799004296 metal binding site 2 [ion binding]; metal-binding site 260799004297 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 260799004298 putative DNA binding site [nucleotide binding]; other site 260799004299 putative metal binding site [ion binding]; other site 260799004300 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 260799004301 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 260799004302 Chain length determinant protein; Region: Wzz; pfam02706 260799004303 Bacterial sugar transferase; Region: Bac_transf; pfam02397 260799004304 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 260799004305 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 260799004306 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 260799004307 O-Antigen ligase; Region: Wzy_C; pfam04932 260799004308 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 260799004309 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 260799004310 active site 260799004311 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 260799004312 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 260799004313 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 260799004314 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004315 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004316 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004317 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004318 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004319 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004320 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004321 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004322 Domain of unknown function DUF11; Region: DUF11; cl17728 260799004323 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004324 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004325 Domain of unknown function DUF11; Region: DUF11; cl17728 260799004326 Domain of unknown function DUF11; Region: DUF11; cl17728 260799004327 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004328 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004329 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004330 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004331 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004332 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004333 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004334 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004335 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004336 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004337 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004338 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004339 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004340 Domain of unknown function DUF11; Region: DUF11; cl17728 260799004341 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004342 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004343 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004344 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799004345 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799004346 Coenzyme A binding pocket [chemical binding]; other site 260799004347 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 260799004348 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 260799004349 catalytic triad [active] 260799004350 conserved cis-peptide bond; other site 260799004351 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 260799004352 EamA-like transporter family; Region: EamA; pfam00892 260799004353 EamA-like transporter family; Region: EamA; pfam00892 260799004354 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 260799004355 RNA/DNA hybrid binding site [nucleotide binding]; other site 260799004356 active site 260799004357 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 260799004358 active site 260799004359 catalytic residues [active] 260799004360 QueT transporter; Region: QueT; pfam06177 260799004361 hypothetical protein; Validated; Region: PRK07708 260799004362 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 260799004363 RNA/DNA hybrid binding site [nucleotide binding]; other site 260799004364 active site 260799004365 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 260799004366 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 260799004367 DNA-binding site [nucleotide binding]; DNA binding site 260799004368 RNA-binding motif; other site 260799004369 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 260799004370 LysE type translocator; Region: LysE; cl00565 260799004371 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 260799004372 Protein of unknown function, DUF485; Region: DUF485; pfam04341 260799004373 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 260799004374 Na binding site [ion binding]; other site 260799004375 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 260799004376 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 260799004377 inhibitor-cofactor binding pocket; inhibition site 260799004378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799004379 catalytic residue [active] 260799004380 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 260799004381 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 260799004382 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 260799004383 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 260799004384 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 260799004385 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 260799004386 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 260799004387 DNA binding residues [nucleotide binding] 260799004388 drug binding residues [chemical binding]; other site 260799004389 dimer interface [polypeptide binding]; other site 260799004390 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 260799004391 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 260799004392 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 260799004393 Predicted membrane protein [Function unknown]; Region: COG2323 260799004394 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 260799004395 putative active site [active] 260799004396 Tic20-like protein; Region: Tic20; pfam09685 260799004397 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 260799004398 dimer interface [polypeptide binding]; other site 260799004399 FMN binding site [chemical binding]; other site 260799004400 NADPH bind site [chemical binding]; other site 260799004401 DJ-1 family protein; Region: not_thiJ; TIGR01383 260799004402 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 260799004403 conserved cys residue [active] 260799004404 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 260799004405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799004406 H+ Antiporter protein; Region: 2A0121; TIGR00900 260799004407 putative substrate translocation pore; other site 260799004408 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799004409 dimerization interface [polypeptide binding]; other site 260799004410 putative DNA binding site [nucleotide binding]; other site 260799004411 putative Zn2+ binding site [ion binding]; other site 260799004412 H+ Antiporter protein; Region: 2A0121; TIGR00900 260799004413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799004414 putative substrate translocation pore; other site 260799004415 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 260799004416 active site 260799004417 metal binding site [ion binding]; metal-binding site 260799004418 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 260799004419 bacterial Hfq-like; Region: Hfq; cd01716 260799004420 hexamer interface [polypeptide binding]; other site 260799004421 Sm1 motif; other site 260799004422 RNA binding site [nucleotide binding]; other site 260799004423 Sm2 motif; other site 260799004424 HD domain; Region: HD_3; pfam13023 260799004425 flagellar motor protein MotP; Reviewed; Region: PRK06743 260799004426 flagellar motor protein MotS; Reviewed; Region: PRK06742 260799004427 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 260799004428 ligand binding site [chemical binding]; other site 260799004429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799004430 active site 260799004431 phosphorylation site [posttranslational modification] 260799004432 intermolecular recognition site; other site 260799004433 dimerization interface [polypeptide binding]; other site 260799004434 flagellar motor switch protein; Reviewed; Region: PRK06782 260799004435 CheC-like family; Region: CheC; pfam04509 260799004436 CheC-like family; Region: CheC; pfam04509 260799004437 CheC-like family; Region: CheC; pfam04509 260799004438 CheC-like family; Region: CheC; pfam04509 260799004439 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 260799004440 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 260799004441 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 260799004442 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 260799004443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799004444 Protein of unknown function (DUF327); Region: DUF327; pfam03885 260799004445 Glutamate-cysteine ligase; Region: GshA; cl19621 260799004446 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 260799004447 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 260799004448 flagellar capping protein; Validated; Region: fliD; PRK06798 260799004449 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 260799004450 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 260799004451 Flagellar protein FliS; Region: FliS; cl00654 260799004452 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 260799004453 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 260799004454 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 260799004455 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 260799004456 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 260799004457 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 260799004458 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 260799004459 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 260799004460 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 260799004461 FliG N-terminal domain; Region: FliG_N; pfam14842 260799004462 FliG middle domain; Region: FliG_M; pfam14841 260799004463 FliG C-terminal domain; Region: FliG_C; pfam01706 260799004464 flagellar assembly protein H; Validated; Region: fliH; PRK06800 260799004465 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 260799004466 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 260799004467 Walker A motif; other site 260799004468 ATP binding site [chemical binding]; other site 260799004469 Walker B motif; other site 260799004470 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 260799004471 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 260799004472 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 260799004473 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 260799004474 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 260799004475 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 260799004476 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 260799004477 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 260799004478 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 260799004479 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 260799004480 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 260799004481 active site 260799004482 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 260799004483 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 260799004484 TPR repeat; Region: TPR_11; pfam13414 260799004485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799004486 binding surface 260799004487 TPR motif; other site 260799004488 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 260799004489 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 260799004490 putative metal binding site; other site 260799004491 Tetratricopeptide repeat; Region: TPR_16; pfam13432 260799004492 putative transposase OrfB; Reviewed; Region: PHA02517 260799004493 flagellin; Provisional; Region: PRK12807 260799004494 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 260799004495 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 260799004496 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 260799004497 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 260799004498 N-acetyl-D-glucosamine binding site [chemical binding]; other site 260799004499 catalytic residue [active] 260799004500 flagellar motor switch protein; Validated; Region: PRK06788 260799004501 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 260799004502 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 260799004503 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 260799004504 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 260799004505 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 260799004506 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 260799004507 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 260799004508 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 260799004509 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 260799004510 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 260799004511 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 260799004512 Predicted transcriptional regulators [Transcription]; Region: COG1378 260799004513 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 260799004514 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 260799004515 C-terminal domain interface [polypeptide binding]; other site 260799004516 sugar binding site [chemical binding]; other site 260799004517 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 260799004518 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 260799004519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799004520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799004521 Dienelactone hydrolase family; Region: DLH; pfam01738 260799004522 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 260799004523 transcriptional repressor DicA; Reviewed; Region: PRK09706 260799004524 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799004525 non-specific DNA binding site [nucleotide binding]; other site 260799004526 salt bridge; other site 260799004527 sequence-specific DNA binding site [nucleotide binding]; other site 260799004528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799004529 H+ Antiporter protein; Region: 2A0121; TIGR00900 260799004530 putative substrate translocation pore; other site 260799004531 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 260799004532 Transcriptional regulator [Transcription]; Region: LysR; COG0583 260799004533 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 260799004534 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 260799004535 dimerization interface [polypeptide binding]; other site 260799004536 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 260799004537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 260799004538 Walker A/P-loop; other site 260799004539 ATP binding site [chemical binding]; other site 260799004540 Q-loop/lid; other site 260799004541 ABC transporter signature motif; other site 260799004542 Walker B; other site 260799004543 D-loop; other site 260799004544 H-loop/switch region; other site 260799004545 TOBE domain; Region: TOBE_2; pfam08402 260799004546 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 260799004547 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 260799004548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799004549 dimer interface [polypeptide binding]; other site 260799004550 conserved gate region; other site 260799004551 putative PBP binding loops; other site 260799004552 ABC-ATPase subunit interface; other site 260799004553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799004554 dimer interface [polypeptide binding]; other site 260799004555 conserved gate region; other site 260799004556 putative PBP binding loops; other site 260799004557 ABC-ATPase subunit interface; other site 260799004558 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 260799004559 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 260799004560 Beta-Casp domain; Region: Beta-Casp; pfam10996 260799004561 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 260799004562 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 260799004563 Cupin; Region: Cupin_1; smart00835 260799004564 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 260799004565 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 260799004566 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 260799004567 catalytic core [active] 260799004568 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 260799004569 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799004570 hypothetical protein; Provisional; Region: PRK09272 260799004571 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 260799004572 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 260799004573 active site 260799004574 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 260799004575 dimer interface [polypeptide binding]; other site 260799004576 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 260799004577 Ligand Binding Site [chemical binding]; other site 260799004578 Molecular Tunnel; other site 260799004579 RNA polymerase factor sigma-70; Validated; Region: PRK06811 260799004580 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799004581 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 260799004582 DNA binding residues [nucleotide binding] 260799004583 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 260799004584 VPS10 domain; Region: VPS10; smart00602 260799004585 VPS10 domain; Region: VPS10; smart00602 260799004586 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 260799004587 Transcriptional regulators [Transcription]; Region: GntR; COG1802 260799004588 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 260799004589 DNA-binding site [nucleotide binding]; DNA binding site 260799004590 FCD domain; Region: FCD; pfam07729 260799004591 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 260799004592 EamA-like transporter family; Region: EamA; pfam00892 260799004593 EamA-like transporter family; Region: EamA; pfam00892 260799004594 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 260799004595 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 260799004596 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 260799004597 Predicted permeases [General function prediction only]; Region: COG0701 260799004598 TIGR03943 family protein; Region: TIGR03943 260799004599 Methyltransferase domain; Region: Methyltransf_24; pfam13578 260799004600 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 260799004601 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 260799004602 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 260799004603 fumarate hydratase; Reviewed; Region: fumC; PRK00485 260799004604 Class II fumarases; Region: Fumarase_classII; cd01362 260799004605 active site 260799004606 tetramer interface [polypeptide binding]; other site 260799004607 Bacterial PH domain; Region: bPH_4; pfam06713 260799004608 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 260799004609 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 260799004610 active site pocket [active] 260799004611 oxyanion hole [active] 260799004612 catalytic triad [active] 260799004613 active site nucleophile [active] 260799004614 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 260799004615 Penicillinase repressor; Region: Penicillinase_R; pfam03965 260799004616 Peptidase family M48; Region: Peptidase_M48; cl12018 260799004617 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 260799004618 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 260799004619 catalytic residues [active] 260799004620 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 260799004621 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 260799004622 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799004623 non-specific DNA binding site [nucleotide binding]; other site 260799004624 salt bridge; other site 260799004625 sequence-specific DNA binding site [nucleotide binding]; other site 260799004626 Cupin domain; Region: Cupin_2; pfam07883 260799004627 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 260799004628 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 260799004629 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 260799004630 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 260799004631 catalytic residue [active] 260799004632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 260799004633 Protein of unknown function (DUF445); Region: DUF445; pfam04286 260799004634 Uncharacterized protein KIAA1328; Region: KIAA1328; pfam15369 260799004635 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 260799004636 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799004637 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 260799004638 DNA binding residues [nucleotide binding] 260799004639 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 260799004640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799004641 active site 260799004642 phosphorylation site [posttranslational modification] 260799004643 intermolecular recognition site; other site 260799004644 dimerization interface [polypeptide binding]; other site 260799004645 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 260799004646 DNA binding residues [nucleotide binding] 260799004647 dimerization interface [polypeptide binding]; other site 260799004648 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 260799004649 Histidine kinase; Region: HisKA_3; pfam07730 260799004650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799004651 Mg2+ binding site [ion binding]; other site 260799004652 G-X-G motif; other site 260799004653 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 260799004654 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 260799004655 Walker A/P-loop; other site 260799004656 ATP binding site [chemical binding]; other site 260799004657 Q-loop/lid; other site 260799004658 ABC transporter signature motif; other site 260799004659 Walker B; other site 260799004660 D-loop; other site 260799004661 H-loop/switch region; other site 260799004662 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 260799004663 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 260799004664 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 260799004665 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 260799004666 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 260799004667 PLD-like domain; Region: PLDc_2; pfam13091 260799004668 putative active site [active] 260799004669 catalytic site [active] 260799004670 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 260799004671 PLD-like domain; Region: PLDc_2; pfam13091 260799004672 putative active site [active] 260799004673 catalytic site [active] 260799004674 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 260799004675 putative nucleotide binding site [chemical binding]; other site 260799004676 uridine monophosphate binding site [chemical binding]; other site 260799004677 homohexameric interface [polypeptide binding]; other site 260799004678 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 260799004679 aspartate ammonia-lyase; Provisional; Region: PRK14515 260799004680 Aspartase; Region: Aspartase; cd01357 260799004681 active sites [active] 260799004682 tetramer interface [polypeptide binding]; other site 260799004683 malate dehydrogenase; Provisional; Region: PRK13529 260799004684 Malic enzyme, N-terminal domain; Region: malic; pfam00390 260799004685 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 260799004686 NAD(P) binding site [chemical binding]; other site 260799004687 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799004688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799004689 ATP binding site [chemical binding]; other site 260799004690 Mg2+ binding site [ion binding]; other site 260799004691 G-X-G motif; other site 260799004692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799004693 active site 260799004694 phosphorylation site [posttranslational modification] 260799004695 intermolecular recognition site; other site 260799004696 dimerization interface [polypeptide binding]; other site 260799004697 YcbB domain; Region: YcbB; pfam08664 260799004698 SWIM zinc finger; Region: SWIM; pfam04434 260799004699 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 260799004700 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 260799004701 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 260799004702 ATP binding site [chemical binding]; other site 260799004703 putative Mg++ binding site [ion binding]; other site 260799004704 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 260799004705 nucleotide binding region [chemical binding]; other site 260799004706 ATP-binding site [chemical binding]; other site 260799004707 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 260799004708 dimer interface [polypeptide binding]; other site 260799004709 active site 260799004710 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799004711 salt bridge; other site 260799004712 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 260799004713 putative dimer interface [polypeptide binding]; other site 260799004714 aspartate kinase; Reviewed; Region: PRK06635 260799004715 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 260799004716 putative nucleotide binding site [chemical binding]; other site 260799004717 putative catalytic residues [active] 260799004718 putative Mg ion binding site [ion binding]; other site 260799004719 putative aspartate binding site [chemical binding]; other site 260799004720 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 260799004721 putative allosteric regulatory site; other site 260799004722 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 260799004723 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 260799004724 YndJ-like protein; Region: YndJ; pfam14158 260799004725 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 260799004726 putative active site [active] 260799004727 nucleotide binding site [chemical binding]; other site 260799004728 nudix motif; other site 260799004729 putative metal binding site [ion binding]; other site 260799004730 S-layer homology domain; Region: SLH; pfam00395 260799004731 S-layer homology domain; Region: SLH; pfam00395 260799004732 S-layer homology domain; Region: SLH; pfam00395 260799004733 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 260799004734 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 260799004735 active site 260799004736 metal binding site [ion binding]; metal-binding site 260799004737 S-layer homology domain; Region: SLH; pfam00395 260799004738 S-layer homology domain; Region: SLH; pfam00395 260799004739 S-layer homology domain; Region: SLH; pfam00395 260799004740 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 260799004741 H+ Antiporter protein; Region: 2A0121; TIGR00900 260799004742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799004743 putative substrate translocation pore; other site 260799004744 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 260799004745 Carbon starvation protein CstA; Region: CstA; pfam02554 260799004746 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 260799004747 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 260799004748 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 260799004749 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 260799004750 dimer interface [polypeptide binding]; other site 260799004751 active site 260799004752 CoA binding pocket [chemical binding]; other site 260799004753 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 260799004754 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 260799004755 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 260799004756 HflX GTPase family; Region: HflX; cd01878 260799004757 G1 box; other site 260799004758 GTP/Mg2+ binding site [chemical binding]; other site 260799004759 Switch I region; other site 260799004760 G2 box; other site 260799004761 G3 box; other site 260799004762 Switch II region; other site 260799004763 G4 box; other site 260799004764 G5 box; other site 260799004765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799004766 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799004767 putative substrate translocation pore; other site 260799004768 cysteine synthase; Region: PLN02565 260799004769 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 260799004770 dimer interface [polypeptide binding]; other site 260799004771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799004772 catalytic residue [active] 260799004773 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799004774 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799004775 Coenzyme A binding pocket [chemical binding]; other site 260799004776 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 260799004777 stage V sporulation protein B; Region: spore_V_B; TIGR02900 260799004778 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 260799004779 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 260799004780 Na2 binding site [ion binding]; other site 260799004781 putative substrate binding site 1 [chemical binding]; other site 260799004782 Na binding site 1 [ion binding]; other site 260799004783 putative substrate binding site 2 [chemical binding]; other site 260799004784 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 260799004785 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 260799004786 NodB motif; other site 260799004787 putative active site [active] 260799004788 putative catalytic site [active] 260799004789 putative Zn binding site [ion binding]; other site 260799004790 Mor transcription activator family; Region: Mor; cl02360 260799004791 Predicted membrane protein [Function unknown]; Region: COG2323 260799004792 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 260799004793 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 260799004794 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 260799004795 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 260799004796 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 260799004797 methionine sulfoxide reductase A; Provisional; Region: PRK14054 260799004798 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 260799004799 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 260799004800 NADP binding site [chemical binding]; other site 260799004801 homodimer interface [polypeptide binding]; other site 260799004802 active site 260799004803 substrate binding site [chemical binding]; other site 260799004804 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 260799004805 homodimer interface [polypeptide binding]; other site 260799004806 substrate-cofactor binding pocket; other site 260799004807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799004808 catalytic residue [active] 260799004809 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 260799004810 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 260799004811 PYR/PP interface [polypeptide binding]; other site 260799004812 dimer interface [polypeptide binding]; other site 260799004813 TPP binding site [chemical binding]; other site 260799004814 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 260799004815 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 260799004816 TPP-binding site [chemical binding]; other site 260799004817 dimer interface [polypeptide binding]; other site 260799004818 acetolactate synthase 1 regulatory subunit; Validated; Region: PRK06737 260799004819 ketol-acid reductoisomerase; Provisional; Region: PRK05479 260799004820 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 260799004821 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 260799004822 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 260799004823 threonine dehydratase; Validated; Region: PRK08639 260799004824 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 260799004825 tetramer interface [polypeptide binding]; other site 260799004826 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799004827 catalytic residue [active] 260799004828 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 260799004829 putative Ile/Val binding site [chemical binding]; other site 260799004830 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 260799004831 putative active site [active] 260799004832 putative metal binding site [ion binding]; other site 260799004833 Protein of unknown function (DUF554); Region: DUF554; pfam04474 260799004834 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799004835 Coenzyme A binding pocket [chemical binding]; other site 260799004836 drug efflux system protein MdtG; Provisional; Region: PRK09874 260799004837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799004838 putative substrate translocation pore; other site 260799004839 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 260799004840 putative active site [active] 260799004841 metal binding site [ion binding]; metal-binding site 260799004842 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 260799004843 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 260799004844 LytTr DNA-binding domain; Region: LytTR; pfam04397 260799004845 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 260799004846 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 260799004847 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 260799004848 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 260799004849 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 260799004850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799004851 Coenzyme A binding pocket [chemical binding]; other site 260799004852 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 260799004853 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 260799004854 active site 260799004855 putative substrate binding pocket [chemical binding]; other site 260799004856 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 260799004857 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 260799004858 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 260799004859 peptide binding site [polypeptide binding]; other site 260799004860 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 260799004861 hypothetical protein; Provisional; Region: PRK06922 260799004862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799004863 S-adenosylmethionine binding site [chemical binding]; other site 260799004864 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 260799004865 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 260799004866 FeS/SAM binding site; other site 260799004867 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 260799004868 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799004869 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799004870 Coenzyme A binding pocket [chemical binding]; other site 260799004871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 260799004872 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799004873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799004874 active site 260799004875 phosphorylation site [posttranslational modification] 260799004876 intermolecular recognition site; other site 260799004877 dimerization interface [polypeptide binding]; other site 260799004878 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799004879 DNA binding site [nucleotide binding] 260799004880 Peptidase family M23; Region: Peptidase_M23; pfam01551 260799004881 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 260799004882 manganese transport protein MntH; Reviewed; Region: PRK00701 260799004883 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 260799004884 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 260799004885 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 260799004886 active site residue [active] 260799004887 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 260799004888 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 260799004889 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 260799004890 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 260799004891 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 260799004892 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 260799004893 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 260799004894 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 260799004895 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 260799004896 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 260799004897 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 260799004898 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 260799004899 intersubunit interface [polypeptide binding]; other site 260799004900 active site 260799004901 catalytic residue [active] 260799004902 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 260799004903 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 260799004904 Nucleoside recognition; Region: Gate; pfam07670 260799004905 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 260799004906 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 260799004907 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 260799004908 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 260799004909 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 260799004910 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 260799004911 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 260799004912 active site 260799004913 catalytic motif [active] 260799004914 Zn binding site [ion binding]; other site 260799004915 hypothetical protein; Provisional; Region: PRK01631 260799004916 Cytochrome C biogenesis protein transmembrane region; Region: DsbD_2; pfam13386 260799004917 VPS10 domain; Region: VPS10; smart00602 260799004918 proline aminopeptidase P II; Provisional; Region: PRK10879 260799004919 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 260799004920 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 260799004921 active site 260799004922 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 260799004923 The first cupredoxin domain of bacteria two domain multicopper oxidase; Region: CuRO_1_2dMco_1; cd13860 260799004924 putative trimer interface [polypeptide binding]; other site 260799004925 trinuclear Cu binding site [ion binding]; other site 260799004926 The second cupredoxin domain of bacterial two domain multicopper oxidase McoN and similar proteins; Region: CuRO_D2_2dMcoN_like; cd04202 260799004927 trimer interface [polypeptide binding]; other site 260799004928 The second cupredoxin domain of bacterial two domain multicopper oxidase McoN and similar proteins; Region: CuRO_D2_2dMcoN_like; cd04202 260799004929 trimer interface [polypeptide binding]; other site 260799004930 trinuclear Cu binding site [ion binding]; other site 260799004931 Bacterial SH3 domain; Region: SH3_3; pfam08239 260799004932 Bacterial SH3 domain; Region: SH3_3; pfam08239 260799004933 Bacterial SH3 domain; Region: SH3_3; pfam08239 260799004934 Bacterial SH3 domain; Region: SH3_3; pfam08239 260799004935 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 260799004936 Bacterial SH3 domain; Region: SH3_3; pfam08239 260799004937 Peptidase family M23; Region: Peptidase_M23; pfam01551 260799004938 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167 260799004939 DNA topoisomerase III; Provisional; Region: PRK07726 260799004940 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 260799004941 active site 260799004942 putative interdomain interaction site [polypeptide binding]; other site 260799004943 putative metal-binding site [ion binding]; other site 260799004944 putative nucleotide binding site [chemical binding]; other site 260799004945 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 260799004946 domain I; other site 260799004947 DNA binding groove [nucleotide binding] 260799004948 phosphate binding site [ion binding]; other site 260799004949 domain II; other site 260799004950 domain III; other site 260799004951 nucleotide binding site [chemical binding]; other site 260799004952 catalytic site [active] 260799004953 domain IV; other site 260799004954 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 260799004955 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 260799004956 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 260799004957 azoreductase; Provisional; Region: PRK13555 260799004958 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 260799004959 dimer interface [polypeptide binding]; other site 260799004960 substrate binding site [chemical binding]; other site 260799004961 metal binding site [ion binding]; metal-binding site 260799004962 CopC domain; Region: CopC; pfam04234 260799004963 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 260799004964 YtkA-like; Region: YtkA; pfam13115 260799004965 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 260799004966 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799004967 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 260799004968 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 260799004969 EamA-like transporter family; Region: EamA; pfam00892 260799004970 EamA-like transporter family; Region: EamA; pfam00892 260799004971 Transcriptional regulator [Transcription]; Region: LysR; COG0583 260799004972 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 260799004973 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 260799004974 dimerization interface [polypeptide binding]; other site 260799004975 Rrf2 family protein; Region: rrf2_super; TIGR00738 260799004976 Transcriptional regulator; Region: Rrf2; pfam02082 260799004977 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 260799004978 catalytic residues [active] 260799004979 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 260799004980 dimer interface [polypeptide binding]; other site 260799004981 FMN binding site [chemical binding]; other site 260799004982 amidase; Provisional; Region: PRK06707 260799004983 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 260799004984 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 260799004985 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 260799004986 tetramer (dimer of dimers) interface [polypeptide binding]; other site 260799004987 NAD binding site [chemical binding]; other site 260799004988 dimer interface [polypeptide binding]; other site 260799004989 substrate binding site [chemical binding]; other site 260799004990 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 260799004991 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 260799004992 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 260799004993 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 260799004994 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 260799004995 S-layer homology domain; Region: SLH; pfam00395 260799004996 S-layer homology domain; Region: SLH; pfam00395 260799004997 S-layer homology domain; Region: SLH; pfam00395 260799004998 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799004999 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799005000 acyl-CoA synthetase; Validated; Region: PRK06839 260799005001 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 260799005002 acyl-activating enzyme (AAE) consensus motif; other site 260799005003 putative AMP binding site [chemical binding]; other site 260799005004 putative active site [active] 260799005005 putative CoA binding site [chemical binding]; other site 260799005006 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 260799005007 dimer interaction site [polypeptide binding]; other site 260799005008 substrate-binding tunnel; other site 260799005009 active site 260799005010 catalytic site [active] 260799005011 substrate binding site [chemical binding]; other site 260799005012 hypothetical protein; Validated; Region: PRK06840 260799005013 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 260799005014 active site 260799005015 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 260799005016 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 260799005017 putative ligand binding site [chemical binding]; other site 260799005018 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 260799005019 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 260799005020 Walker A/P-loop; other site 260799005021 ATP binding site [chemical binding]; other site 260799005022 Q-loop/lid; other site 260799005023 ABC transporter signature motif; other site 260799005024 Walker B; other site 260799005025 D-loop; other site 260799005026 H-loop/switch region; other site 260799005027 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 260799005028 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 260799005029 Walker A/P-loop; other site 260799005030 ATP binding site [chemical binding]; other site 260799005031 Q-loop/lid; other site 260799005032 ABC transporter signature motif; other site 260799005033 Walker B; other site 260799005034 D-loop; other site 260799005035 H-loop/switch region; other site 260799005036 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 260799005037 TM-ABC transporter signature motif; other site 260799005038 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 260799005039 TM-ABC transporter signature motif; other site 260799005040 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 260799005041 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 260799005042 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 260799005043 dimerization interface [polypeptide binding]; other site 260799005044 Tautomerase enzyme; Region: Tautomerase_2; pfam14552 260799005045 active site 1 [active] 260799005046 dimer interface [polypeptide binding]; other site 260799005047 hexamer interface [polypeptide binding]; other site 260799005048 active site 2 [active] 260799005049 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 260799005050 Transcriptional regulators [Transcription]; Region: MarR; COG1846 260799005051 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799005052 putative Zn2+ binding site [ion binding]; other site 260799005053 putative DNA binding site [nucleotide binding]; other site 260799005054 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 260799005055 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 260799005056 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 260799005057 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 260799005058 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 260799005059 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 260799005060 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 260799005061 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 260799005062 Walker A/P-loop; other site 260799005063 ATP binding site [chemical binding]; other site 260799005064 Q-loop/lid; other site 260799005065 ABC transporter signature motif; other site 260799005066 Walker B; other site 260799005067 D-loop; other site 260799005068 H-loop/switch region; other site 260799005069 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 260799005070 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 260799005071 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 260799005072 Walker A/P-loop; other site 260799005073 ATP binding site [chemical binding]; other site 260799005074 Q-loop/lid; other site 260799005075 ABC transporter signature motif; other site 260799005076 Walker B; other site 260799005077 D-loop; other site 260799005078 H-loop/switch region; other site 260799005079 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 260799005080 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 260799005081 putative dimer interface [polypeptide binding]; other site 260799005082 catalytic triad [active] 260799005083 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 260799005084 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 260799005085 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 260799005086 dimer interface [polypeptide binding]; other site 260799005087 FMN binding site [chemical binding]; other site 260799005088 Bacterial SH3 domain; Region: SH3_3; pfam08239 260799005089 Bacterial SH3 domain; Region: SH3_3; pfam08239 260799005090 Bacterial SH3 domain; Region: SH3_3; pfam08239 260799005091 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 260799005092 NlpC/P60 family; Region: NLPC_P60; pfam00877 260799005093 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 260799005094 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799005095 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799005096 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799005097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799005098 active site 260799005099 phosphorylation site [posttranslational modification] 260799005100 intermolecular recognition site; other site 260799005101 dimerization interface [polypeptide binding]; other site 260799005102 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799005103 DNA binding site [nucleotide binding] 260799005104 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799005105 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799005106 dimerization interface [polypeptide binding]; other site 260799005107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799005108 dimer interface [polypeptide binding]; other site 260799005109 phosphorylation site [posttranslational modification] 260799005110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799005111 ATP binding site [chemical binding]; other site 260799005112 Mg2+ binding site [ion binding]; other site 260799005113 G-X-G motif; other site 260799005114 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 260799005115 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 260799005116 classical (c) SDRs; Region: SDR_c; cd05233 260799005117 NAD(P) binding site [chemical binding]; other site 260799005118 active site 260799005119 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 260799005120 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 260799005121 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 260799005122 NodB motif; other site 260799005123 active site 260799005124 catalytic site [active] 260799005125 metal binding site [ion binding]; metal-binding site 260799005126 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 260799005127 nudix motif; other site 260799005128 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 260799005129 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 260799005130 homoserine dehydrogenase; Provisional; Region: PRK06349 260799005131 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 260799005132 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 260799005133 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 260799005134 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 260799005135 cysteine synthase; Region: PLN02565 260799005136 homodimer interface [polypeptide binding]; other site 260799005137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799005138 catalytic residue [active] 260799005139 homoserine kinase; Provisional; Region: PRK01212 260799005140 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 260799005141 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 260799005142 Protein of unknown function (DUF1183); Region: DUF1183; pfam06682 260799005143 Glycosyl hydrolases related to GH101 family, GHL1-GHL3; Region: GHL1-3; pfam11308 260799005144 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 260799005145 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799005146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799005147 active site 260799005148 phosphorylation site [posttranslational modification] 260799005149 intermolecular recognition site; other site 260799005150 dimerization interface [polypeptide binding]; other site 260799005151 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799005152 DNA binding site [nucleotide binding] 260799005153 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799005154 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799005155 dimerization interface [polypeptide binding]; other site 260799005156 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799005157 dimer interface [polypeptide binding]; other site 260799005158 phosphorylation site [posttranslational modification] 260799005159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799005160 ATP binding site [chemical binding]; other site 260799005161 Mg2+ binding site [ion binding]; other site 260799005162 G-X-G motif; other site 260799005163 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 260799005164 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 260799005165 NodB motif; other site 260799005166 active site 260799005167 catalytic site [active] 260799005168 Zn binding site [ion binding]; other site 260799005169 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 260799005170 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 260799005171 MgtC family; Region: MgtC; pfam02308 260799005172 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 260799005173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799005174 Coenzyme A binding pocket [chemical binding]; other site 260799005175 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 260799005176 IucA / IucC family; Region: IucA_IucC; pfam04183 260799005177 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 260799005178 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 260799005179 IucA / IucC family; Region: IucA_IucC; pfam04183 260799005180 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 260799005181 acyl-CoA synthetase; Validated; Region: PRK08308 260799005182 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 260799005183 acyl-activating enzyme (AAE) consensus motif; other site 260799005184 AMP binding site [chemical binding]; other site 260799005185 active site 260799005186 CoA binding site [chemical binding]; other site 260799005187 acyl carrier protein; Provisional; Region: PRK07639 260799005188 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 260799005189 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 260799005190 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 260799005191 Lysine efflux permease [General function prediction only]; Region: COG1279 260799005192 Protein of unknown function (DUF3933); Region: DUF3933; pfam13069 260799005193 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 260799005194 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 260799005195 active site 260799005196 nucleophile elbow; other site 260799005197 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 260799005198 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 260799005199 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 260799005200 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 260799005201 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 260799005202 nudix motif; other site 260799005203 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 260799005204 homodimer interface [polypeptide binding]; other site 260799005205 NAD binding pocket [chemical binding]; other site 260799005206 ATP binding pocket [chemical binding]; other site 260799005207 Mg binding site [ion binding]; other site 260799005208 active-site loop [active] 260799005209 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 260799005210 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 260799005211 Subtilase family; Region: Peptidase_S8; pfam00082 260799005212 active site 260799005213 catalytic residues [active] 260799005214 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799005215 dimerization interface [polypeptide binding]; other site 260799005216 putative DNA binding site [nucleotide binding]; other site 260799005217 putative Zn2+ binding site [ion binding]; other site 260799005218 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 260799005219 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 260799005220 active site 260799005221 catalytic tetrad [active] 260799005222 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 260799005223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799005224 putative substrate translocation pore; other site 260799005225 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 260799005226 DinB superfamily; Region: DinB_2; pfam12867 260799005227 GTPase RsgA; Reviewed; Region: PRK01889 260799005228 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 260799005229 RNA binding site [nucleotide binding]; other site 260799005230 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 260799005231 GTPase/Zn-binding domain interface [polypeptide binding]; other site 260799005232 GTP/Mg2+ binding site [chemical binding]; other site 260799005233 G4 box; other site 260799005234 G5 box; other site 260799005235 G1 box; other site 260799005236 Switch I region; other site 260799005237 G2 box; other site 260799005238 G3 box; other site 260799005239 Switch II region; other site 260799005240 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 260799005241 Cache domain; Region: Cache_1; pfam02743 260799005242 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 260799005243 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799005244 dimerization interface [polypeptide binding]; other site 260799005245 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 260799005246 dimer interface [polypeptide binding]; other site 260799005247 putative CheW interface [polypeptide binding]; other site 260799005248 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 260799005249 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 260799005250 Ferritin-like domain; Region: Ferritin; pfam00210 260799005251 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 260799005252 dimerization interface [polypeptide binding]; other site 260799005253 DPS ferroxidase diiron center [ion binding]; other site 260799005254 ion pore; other site 260799005255 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 260799005256 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 260799005257 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 260799005258 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 260799005259 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 260799005260 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 260799005261 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 260799005262 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 260799005263 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 260799005264 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799005265 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 260799005266 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 260799005267 active site 260799005268 catalytic tetrad [active] 260799005269 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 260799005270 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 260799005271 P-loop, Walker A motif; other site 260799005272 Base recognition motif; other site 260799005273 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 260799005274 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 260799005275 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799005276 Coenzyme A binding pocket [chemical binding]; other site 260799005277 Replication-relaxation; Region: Replic_Relax; pfam13814 260799005278 exosporium leader peptide; Region: exospor_lead; TIGR03720 260799005279 Predicted membrane protein [Function unknown]; Region: COG4640 260799005280 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959 260799005281 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 260799005282 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 260799005283 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 260799005284 metal binding site [ion binding]; metal-binding site 260799005285 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 260799005286 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 260799005287 NAD binding site [chemical binding]; other site 260799005288 active site 260799005289 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 260799005290 active site 260799005291 FMN binding site [chemical binding]; other site 260799005292 substrate binding site [chemical binding]; other site 260799005293 homotetramer interface [polypeptide binding]; other site 260799005294 catalytic residue [active] 260799005295 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 260799005296 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 260799005297 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 260799005298 DNA binding site [nucleotide binding] 260799005299 active site 260799005300 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 260799005301 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 260799005302 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 260799005303 peptide binding site [polypeptide binding]; other site 260799005304 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 260799005305 active site 260799005306 metal binding site [ion binding]; metal-binding site 260799005307 short chain dehydrogenase; Provisional; Region: PRK08309 260799005308 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 260799005309 catalytic core [active] 260799005310 CotH protein; Region: CotH; pfam08757 260799005311 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 260799005312 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 260799005313 nudix motif; other site 260799005314 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 260799005315 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 260799005316 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 260799005317 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 260799005318 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 260799005319 Cl binding site [ion binding]; other site 260799005320 oligomer interface [polypeptide binding]; other site 260799005321 Predicted permeases [General function prediction only]; Region: COG0701 260799005322 Predicted membrane protein [Function unknown]; Region: COG3689 260799005323 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 260799005324 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 260799005325 PLD-like domain; Region: PLDc_2; pfam13091 260799005326 putative active site [active] 260799005327 catalytic site [active] 260799005328 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 260799005329 PLD-like domain; Region: PLDc_2; pfam13091 260799005330 putative active site [active] 260799005331 catalytic site [active] 260799005332 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 260799005333 NAD(P) binding site [chemical binding]; other site 260799005334 active site 260799005335 Protein of unknown function (DUF456); Region: DUF456; pfam04306 260799005336 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 260799005337 Domain of unknown function DUF21; Region: DUF21; pfam01595 260799005338 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 260799005339 Transporter associated domain; Region: CorC_HlyC; smart01091 260799005340 FOG: CBS domain [General function prediction only]; Region: COG0517 260799005341 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 260799005342 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 260799005343 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 260799005344 dimer interface [polypeptide binding]; other site 260799005345 putative tRNA-binding site [nucleotide binding]; other site 260799005346 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 260799005347 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 260799005348 stage II sporulation protein P; Region: spore_II_P; TIGR02867 260799005349 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 260799005350 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799005351 Coenzyme A binding pocket [chemical binding]; other site 260799005352 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 260799005353 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 260799005354 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 260799005355 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+ for their activity and contain a highly...; Region: Nudix_Hydrolase_6; cd04663 260799005356 nudix motif; other site 260799005357 amidase; Provisional; Region: PRK06828 260799005358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799005359 putative substrate translocation pore; other site 260799005360 H+ Antiporter protein; Region: 2A0121; TIGR00900 260799005361 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 260799005362 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 260799005363 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 260799005364 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 260799005365 catalytic core [active] 260799005366 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799005367 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 260799005368 active site 260799005369 motif I; other site 260799005370 motif II; other site 260799005371 DinB superfamily; Region: DinB_2; pfam12867 260799005372 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 260799005373 alanine racemase; Reviewed; Region: alr; PRK00053 260799005374 active site 260799005375 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 260799005376 dimer interface [polypeptide binding]; other site 260799005377 substrate binding site [chemical binding]; other site 260799005378 catalytic residues [active] 260799005379 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 260799005380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799005381 S-adenosylmethionine binding site [chemical binding]; other site 260799005382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799005383 Coenzyme A binding pocket [chemical binding]; other site 260799005384 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799005385 Coenzyme A binding pocket [chemical binding]; other site 260799005386 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 260799005387 active site 260799005388 ATP binding site [chemical binding]; other site 260799005389 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 260799005390 glycosyltransferase, MGT family; Region: MGT; TIGR01426 260799005391 active site 260799005392 TDP-binding site; other site 260799005393 acceptor substrate-binding pocket; other site 260799005394 homodimer interface [polypeptide binding]; other site 260799005395 Uncharacterized conserved protein [Function unknown]; Region: COG1284 260799005396 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 260799005397 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 260799005398 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 260799005399 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 260799005400 DNA-binding site [nucleotide binding]; DNA binding site 260799005401 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 260799005402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799005403 homodimer interface [polypeptide binding]; other site 260799005404 catalytic residue [active] 260799005405 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 260799005406 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799005407 Coenzyme A binding pocket [chemical binding]; other site 260799005408 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 260799005409 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 260799005410 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799005411 Coenzyme A binding pocket [chemical binding]; other site 260799005412 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 260799005413 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 260799005414 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799005415 Coenzyme A binding pocket [chemical binding]; other site 260799005416 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 260799005417 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 260799005418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799005419 S-adenosylmethionine binding site [chemical binding]; other site 260799005420 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 260799005421 Potassium binding sites [ion binding]; other site 260799005422 Cesium cation binding sites [ion binding]; other site 260799005423 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 260799005424 DEAD-like helicases superfamily; Region: DEXDc; smart00487 260799005425 ATP binding site [chemical binding]; other site 260799005426 putative Mg++ binding site [ion binding]; other site 260799005427 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 260799005428 nucleotide binding region [chemical binding]; other site 260799005429 ATP-binding site [chemical binding]; other site 260799005430 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 260799005431 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 260799005432 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 260799005433 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 260799005434 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 260799005435 NADP binding site [chemical binding]; other site 260799005436 dimer interface [polypeptide binding]; other site 260799005437 RNA polymerase sigma factor; Provisional; Region: PRK12543 260799005438 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799005439 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 260799005440 DNA binding residues [nucleotide binding] 260799005441 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 260799005442 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 260799005443 Protein of unknown function (DUF3925); Region: DUF3925; pfam13063 260799005444 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 260799005445 catalytic residues [active] 260799005446 dimer interface [polypeptide binding]; other site 260799005447 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 260799005448 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 260799005449 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 260799005450 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 260799005451 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 260799005452 Protein of unknown function DUF58; Region: DUF58; pfam01882 260799005453 MoxR-like ATPases [General function prediction only]; Region: COG0714 260799005454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799005455 Walker A motif; other site 260799005456 ATP binding site [chemical binding]; other site 260799005457 Walker B motif; other site 260799005458 arginine finger; other site 260799005459 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 260799005460 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 260799005461 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 260799005462 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 260799005463 [4Fe-4S] binding site [ion binding]; other site 260799005464 molybdopterin cofactor binding site [chemical binding]; other site 260799005465 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 260799005466 molybdopterin cofactor binding site; other site 260799005467 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 260799005468 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 260799005469 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 260799005470 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 260799005471 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 260799005472 Predicted transcriptional regulators [Transcription]; Region: COG1725 260799005473 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 260799005474 DNA-binding site [nucleotide binding]; DNA binding site 260799005475 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 260799005476 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 260799005477 Walker A/P-loop; other site 260799005478 ATP binding site [chemical binding]; other site 260799005479 Q-loop/lid; other site 260799005480 ABC transporter signature motif; other site 260799005481 Walker B; other site 260799005482 D-loop; other site 260799005483 H-loop/switch region; other site 260799005484 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 260799005485 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 260799005486 ligand binding site [chemical binding]; other site 260799005487 flexible hinge region; other site 260799005488 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 260799005489 putative switch regulator; other site 260799005490 non-specific DNA interactions [nucleotide binding]; other site 260799005491 DNA binding site [nucleotide binding] 260799005492 sequence specific DNA binding site [nucleotide binding]; other site 260799005493 putative cAMP binding site [chemical binding]; other site 260799005494 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 260799005495 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 260799005496 FeS/SAM binding site; other site 260799005497 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 260799005498 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 260799005499 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 260799005500 ATP binding site [chemical binding]; other site 260799005501 substrate interface [chemical binding]; other site 260799005502 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 260799005503 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 260799005504 dimer interface [polypeptide binding]; other site 260799005505 putative functional site; other site 260799005506 putative MPT binding site; other site 260799005507 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 260799005508 MoaE homodimer interface [polypeptide binding]; other site 260799005509 MoaD interaction [polypeptide binding]; other site 260799005510 active site residues [active] 260799005511 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 260799005512 MoaE interaction surface [polypeptide binding]; other site 260799005513 MoeB interaction surface [polypeptide binding]; other site 260799005514 thiocarboxylated glycine; other site 260799005515 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 260799005516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799005517 putative substrate translocation pore; other site 260799005518 Membrane transport protein; Region: Mem_trans; cl09117 260799005519 precorrin-2 dehydrogenase; Validated; Region: PRK06719 260799005520 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 260799005521 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 260799005522 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 260799005523 putative active site [active] 260799005524 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 260799005525 putative active site [active] 260799005526 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 260799005527 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 260799005528 active site 260799005529 SAM binding site [chemical binding]; other site 260799005530 homodimer interface [polypeptide binding]; other site 260799005531 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cl03649 260799005532 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 260799005533 [2Fe-2S] cluster binding site [ion binding]; other site 260799005534 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 260799005535 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 260799005536 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 260799005537 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 260799005538 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 260799005539 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 260799005540 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 260799005541 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 260799005542 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 260799005543 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 260799005544 Fe binding site [ion binding]; other site 260799005545 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 260799005546 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 260799005547 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 260799005548 Protein of unknown function (DUF1682); Region: DUF1682; pfam07946 260799005549 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 260799005550 N-acetyltransferase; Region: Acetyltransf_2; cl00949 260799005551 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799005552 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 260799005553 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 260799005554 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 260799005555 DNA translocase FtsK; Provisional; Region: PRK10263 260799005556 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 260799005557 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 260799005558 Zn2+ binding site [ion binding]; other site 260799005559 Mg2+ binding site [ion binding]; other site 260799005560 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 260799005561 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 260799005562 ABC transporter; Region: ABC_tran_2; pfam12848 260799005563 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 260799005564 Bax inhibitor 1 like; Region: BaxI_1; cl17691 260799005565 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 260799005566 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 260799005567 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 260799005568 dimer interface [polypeptide binding]; other site 260799005569 ssDNA binding site [nucleotide binding]; other site 260799005570 tetramer (dimer of dimers) interface [polypeptide binding]; other site 260799005571 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799005572 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799005573 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 260799005574 Virulence factor; Region: Virulence_fact; pfam13769 260799005575 HEAT repeats; Region: HEAT_2; pfam13646 260799005576 HEAT repeats; Region: HEAT_2; pfam13646 260799005577 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 260799005578 Protein of unknown function, DUF393; Region: DUF393; pfam04134 260799005579 Disulphide isomerase; Region: Disulph_isomer; pfam06491 260799005580 Brix domain; Region: Brix; cl00935 260799005581 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 260799005582 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 260799005583 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 260799005584 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 260799005585 active site 260799005586 HIGH motif; other site 260799005587 KMSK motif region; other site 260799005588 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 260799005589 tRNA binding surface [nucleotide binding]; other site 260799005590 anticodon binding site; other site 260799005591 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 260799005592 Methyltransferase domain; Region: Methyltransf_31; pfam13847 260799005593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799005594 S-adenosylmethionine binding site [chemical binding]; other site 260799005595 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 260799005596 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 260799005597 active site 260799005598 HIGH motif; other site 260799005599 KMSKS motif; other site 260799005600 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 260799005601 tRNA binding surface [nucleotide binding]; other site 260799005602 anticodon binding site; other site 260799005603 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 260799005604 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 260799005605 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 260799005606 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 260799005607 Zn binding site [ion binding]; other site 260799005608 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 260799005609 Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cl19106 260799005610 Dimer interface [polypeptide binding]; other site 260799005611 anticodon binding site; other site 260799005612 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 260799005613 homodimer interface [polypeptide binding]; other site 260799005614 motif 1; other site 260799005615 motif 2; other site 260799005616 active site 260799005617 motif 3; other site 260799005618 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 260799005619 metal ion-dependent adhesion site (MIDAS); other site 260799005620 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 260799005621 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 260799005622 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 260799005623 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799005624 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 260799005625 G1 box; other site 260799005626 Walker A motif; other site 260799005627 ATP binding site [chemical binding]; other site 260799005628 GTP/Mg2+ binding site [chemical binding]; other site 260799005629 Switch I region; other site 260799005630 G3 box; other site 260799005631 Switch II region; other site 260799005632 G4 box; other site 260799005633 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 260799005634 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 260799005635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799005636 binding surface 260799005637 TPR motif; other site 260799005638 TPR repeat; Region: TPR_11; pfam13414 260799005639 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799005640 binding surface 260799005641 TPR motif; other site 260799005642 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799005643 binding surface 260799005644 Tetratricopeptide repeat; Region: TPR_12; pfam13424 260799005645 TPR motif; other site 260799005646 Tetratricopeptide repeat; Region: TPR_19; pfam14559 260799005647 SseB protein N-terminal domain; Region: SseB; pfam07179 260799005648 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 260799005649 Pre-toxin TG; Region: PT-TG; pfam14449 260799005650 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 260799005651 Immunity protein Imm3; Region: Imm3; pfam14425 260799005652 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 260799005653 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 260799005654 catalytic residues [active] 260799005655 catalytic nucleophile [active] 260799005656 Recombinase; Region: Recombinase; pfam07508 260799005657 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 260799005658 Transposase; Region: DEDD_Tnp_IS110; pfam01548 260799005659 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 260799005660 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 260799005661 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 260799005662 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 260799005663 Glycerate kinase family; Region: Gly_kinase; cl00841 260799005664 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 260799005665 anion transporter; Region: dass; TIGR00785 260799005666 transmembrane helices; other site 260799005667 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799005668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799005669 active site 260799005670 phosphorylation site [posttranslational modification] 260799005671 intermolecular recognition site; other site 260799005672 dimerization interface [polypeptide binding]; other site 260799005673 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799005674 DNA binding site [nucleotide binding] 260799005675 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799005676 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799005677 dimerization interface [polypeptide binding]; other site 260799005678 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799005679 dimer interface [polypeptide binding]; other site 260799005680 phosphorylation site [posttranslational modification] 260799005681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799005682 ATP binding site [chemical binding]; other site 260799005683 Mg2+ binding site [ion binding]; other site 260799005684 G-X-G motif; other site 260799005685 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 260799005686 Predicted membrane protein [Function unknown]; Region: COG3212 260799005687 Predicted membrane protein [Function unknown]; Region: COG3212 260799005688 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 260799005689 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 260799005690 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 260799005691 Na2 binding site [ion binding]; other site 260799005692 putative substrate binding site 1 [chemical binding]; other site 260799005693 Na binding site 1 [ion binding]; other site 260799005694 putative substrate binding site 2 [chemical binding]; other site 260799005695 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 260799005696 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799005697 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 260799005698 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 260799005699 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 260799005700 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799005701 active site 260799005702 motif I; other site 260799005703 motif II; other site 260799005704 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 260799005705 fructuronate transporter; Provisional; Region: PRK10034; cl15264 260799005706 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 260799005707 putative active site [active] 260799005708 metal binding site [ion binding]; metal-binding site 260799005709 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 260799005710 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 260799005711 homodimer interaction site [polypeptide binding]; other site 260799005712 cofactor binding site; other site 260799005713 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799005714 Coenzyme A binding pocket [chemical binding]; other site 260799005715 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 260799005716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799005717 Coenzyme A binding pocket [chemical binding]; other site 260799005718 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 260799005719 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 260799005720 Walker A/P-loop; other site 260799005721 ATP binding site [chemical binding]; other site 260799005722 Q-loop/lid; other site 260799005723 ABC transporter signature motif; other site 260799005724 Walker B; other site 260799005725 D-loop; other site 260799005726 H-loop/switch region; other site 260799005727 YpjP-like protein; Region: YpjP; pfam14005 260799005728 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 260799005729 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799005730 active site 260799005731 motif I; other site 260799005732 motif II; other site 260799005733 hypothetical protein; Provisional; Region: PRK06724 260799005734 active site 260799005735 Phosphotransferase enzyme family; Region: APH; pfam01636 260799005736 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 260799005737 active site 260799005738 ATP binding site [chemical binding]; other site 260799005739 substrate binding site [chemical binding]; other site 260799005740 Peptidase family S41; Region: Peptidase_S41; pfam03572 260799005741 Beta-lactamase; Region: Beta-lactamase; pfam00144 260799005742 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 260799005743 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 260799005744 dimerization interface [polypeptide binding]; other site 260799005745 active site 260799005746 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 260799005747 folate binding site [chemical binding]; other site 260799005748 NADP+ binding site [chemical binding]; other site 260799005749 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 260799005750 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 260799005751 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 260799005752 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 260799005753 azoreductase; Reviewed; Region: PRK00170 260799005754 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 260799005755 putative acyl-acceptor binding pocket; other site 260799005756 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 260799005757 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 260799005758 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 260799005759 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 260799005760 EDD domain protein, DegV family; Region: DegV; TIGR00762 260799005761 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 260799005762 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 260799005763 Cu(I) binding site [ion binding]; other site 260799005764 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 260799005765 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 260799005766 putative dimer interface [polypeptide binding]; other site 260799005767 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 260799005768 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 260799005769 active site 260799005770 dimer interface [polypeptide binding]; other site 260799005771 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 260799005772 Ligand Binding Site [chemical binding]; other site 260799005773 Molecular Tunnel; other site 260799005774 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 260799005775 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 260799005776 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 260799005777 siderophore binding site; other site 260799005778 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 260799005779 homodimer interface [polypeptide binding]; other site 260799005780 substrate-cofactor binding pocket; other site 260799005781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799005782 catalytic residue [active] 260799005783 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 260799005784 FMN binding site [chemical binding]; other site 260799005785 dimer interface [polypeptide binding]; other site 260799005786 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 260799005787 nudix motif; other site 260799005788 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 260799005789 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 260799005790 putative dimer interface [polypeptide binding]; other site 260799005791 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 260799005792 Mechanosensitive ion channel; Region: MS_channel; pfam00924 260799005793 GAF domain; Region: GAF_2; pfam13185 260799005794 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 260799005795 Histidine kinase; Region: HisKA_3; pfam07730 260799005796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799005797 ATP binding site [chemical binding]; other site 260799005798 Mg2+ binding site [ion binding]; other site 260799005799 G-X-G motif; other site 260799005800 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 260799005801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799005802 active site 260799005803 phosphorylation site [posttranslational modification] 260799005804 intermolecular recognition site; other site 260799005805 dimerization interface [polypeptide binding]; other site 260799005806 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 260799005807 DNA binding residues [nucleotide binding] 260799005808 dimerization interface [polypeptide binding]; other site 260799005809 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 260799005810 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 260799005811 NAD binding site [chemical binding]; other site 260799005812 substrate binding site [chemical binding]; other site 260799005813 catalytic Zn binding site [ion binding]; other site 260799005814 tetramer interface [polypeptide binding]; other site 260799005815 structural Zn binding site [ion binding]; other site 260799005816 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 260799005817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799005818 dimer interface [polypeptide binding]; other site 260799005819 conserved gate region; other site 260799005820 ABC-ATPase subunit interface; other site 260799005821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 260799005822 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 260799005823 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 260799005824 active site 260799005825 Predicted flavoprotein [General function prediction only]; Region: COG0431 260799005826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799005827 H+ Antiporter protein; Region: 2A0121; TIGR00900 260799005828 putative substrate translocation pore; other site 260799005829 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 260799005830 putative active site [active] 260799005831 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 260799005832 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 260799005833 Walker A/P-loop; other site 260799005834 ATP binding site [chemical binding]; other site 260799005835 Q-loop/lid; other site 260799005836 ABC transporter signature motif; other site 260799005837 Walker B; other site 260799005838 D-loop; other site 260799005839 H-loop/switch region; other site 260799005840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799005841 dimer interface [polypeptide binding]; other site 260799005842 conserved gate region; other site 260799005843 putative PBP binding loops; other site 260799005844 ABC-ATPase subunit interface; other site 260799005845 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 260799005846 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 260799005847 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 260799005848 Protein of unknown function (DUF524); Region: DUF524; pfam04411 260799005849 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; cl19511 260799005850 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 260799005851 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 260799005852 Domain of unknown function DUF21; Region: DUF21; pfam01595 260799005853 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 260799005854 Transporter associated domain; Region: CorC_HlyC; smart01091 260799005855 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 260799005856 NAD(P) binding site [chemical binding]; other site 260799005857 catalytic residues [active] 260799005858 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 260799005859 Histidine kinase N terminal; Region: HisK_N; pfam09385 260799005860 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799005861 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799005862 dimer interface [polypeptide binding]; other site 260799005863 phosphorylation site [posttranslational modification] 260799005864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799005865 ATP binding site [chemical binding]; other site 260799005866 Mg2+ binding site [ion binding]; other site 260799005867 G-X-G motif; other site 260799005868 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 260799005869 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 260799005870 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 260799005871 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 260799005872 inhibitor-cofactor binding pocket; inhibition site 260799005873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799005874 catalytic residue [active] 260799005875 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 260799005876 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 260799005877 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 260799005878 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 260799005879 metal binding site [ion binding]; metal-binding site 260799005880 dimer interface [polypeptide binding]; other site 260799005881 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 260799005882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799005883 Coenzyme A binding pocket [chemical binding]; other site 260799005884 PAS fold; Region: PAS_4; pfam08448 260799005885 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 260799005886 putative active site [active] 260799005887 heme pocket [chemical binding]; other site 260799005888 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 260799005889 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799005890 Walker A motif; other site 260799005891 ATP binding site [chemical binding]; other site 260799005892 Walker B motif; other site 260799005893 arginine finger; other site 260799005894 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 260799005895 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 260799005896 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 260799005897 FeS/SAM binding site; other site 260799005898 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 260799005899 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 260799005900 toxin interface [polypeptide binding]; other site 260799005901 Zn binding site [ion binding]; other site 260799005902 hypothetical protein; Provisional; Region: PRK13672 260799005903 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 260799005904 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 260799005905 YozD-like protein; Region: YozD; pfam14162 260799005906 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 260799005907 Catalytic domain of Protein Kinases; Region: PKc; cd00180 260799005908 active site 260799005909 ATP binding site [chemical binding]; other site 260799005910 substrate binding site [chemical binding]; other site 260799005911 activation loop (A-loop); other site 260799005912 Arrestin (or S-antigen), N-terminal domain; Region: Arrestin_N; cl19290 260799005913 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 260799005914 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 260799005915 active site 260799005916 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 260799005917 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 260799005918 catalytic residues [active] 260799005919 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 260799005920 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 260799005921 DNA binding site [nucleotide binding] 260799005922 active site 260799005923 Int/Topo IB signature motif; other site 260799005924 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 260799005925 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 260799005926 S-layer homology domain; Region: SLH; pfam00395 260799005927 S-layer homology domain; Region: SLH; pfam00395 260799005928 S-layer homology domain; Region: SLH; pfam00395 260799005929 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 260799005930 PLD-like domain; Region: PLDc_2; pfam13091 260799005931 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 260799005932 putative active site [active] 260799005933 putative active site [active] 260799005934 catalytic site [active] 260799005935 catalytic site [active] 260799005936 Restriction endonuclease; Region: Mrr_cat; pfam04471 260799005937 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799005938 non-specific DNA binding site [nucleotide binding]; other site 260799005939 salt bridge; other site 260799005940 sequence-specific DNA binding site [nucleotide binding]; other site 260799005941 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 260799005942 Replication-relaxation; Region: Replic_Relax; pfam13814 260799005943 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 260799005944 homotrimer interaction site [polypeptide binding]; other site 260799005945 putative active site [active] 260799005946 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 260799005947 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 260799005948 C1q domain; Region: C1q; cl17543 260799005949 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 260799005950 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 260799005951 YolD-like protein; Region: YolD; pfam08863 260799005952 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 260799005953 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 260799005954 KTSC domain; Region: KTSC; pfam13619 260799005955 Transglycosylase; Region: Transgly; pfam00912 260799005956 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 260799005957 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 260799005958 Nucleoporin FG repeat region; Region: Nucleoporin_FG; pfam13634 260799005959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799005960 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799005961 putative substrate translocation pore; other site 260799005962 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 260799005963 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 260799005964 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 260799005965 dimer interface [polypeptide binding]; other site 260799005966 active site 260799005967 coenzyme A binding site [chemical binding]; other site 260799005968 citrylCoA binding site [chemical binding]; other site 260799005969 oxalacetate/citrate binding site [chemical binding]; other site 260799005970 catalytic triad [active] 260799005971 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 260799005972 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 260799005973 tetramer interface [polypeptide binding]; other site 260799005974 active site 260799005975 Mg2+/Mn2+ binding site [ion binding]; other site 260799005976 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 260799005977 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 260799005978 active site 260799005979 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 260799005980 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 260799005981 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 260799005982 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 260799005983 tetrameric interface [polypeptide binding]; other site 260799005984 NAD binding site [chemical binding]; other site 260799005985 catalytic residues [active] 260799005986 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 260799005987 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 260799005988 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 260799005989 substrate binding site [chemical binding]; other site 260799005990 oxyanion hole (OAH) forming residues; other site 260799005991 trimer interface [polypeptide binding]; other site 260799005992 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 260799005993 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 260799005994 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 260799005995 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 260799005996 active site 260799005997 metal binding site [ion binding]; metal-binding site 260799005998 DNA binding site [nucleotide binding] 260799005999 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 260799006000 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 260799006001 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 260799006002 Walker A/P-loop; other site 260799006003 ATP binding site [chemical binding]; other site 260799006004 Q-loop/lid; other site 260799006005 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 260799006006 ABC transporter signature motif; other site 260799006007 Walker B; other site 260799006008 D-loop; other site 260799006009 H-loop/switch region; other site 260799006010 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799006011 dimerization interface [polypeptide binding]; other site 260799006012 putative DNA binding site [nucleotide binding]; other site 260799006013 putative Zn2+ binding site [ion binding]; other site 260799006014 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 260799006015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799006016 putative substrate translocation pore; other site 260799006017 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 260799006018 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 260799006019 NAD(P) binding site [chemical binding]; other site 260799006020 active site 260799006021 isochorismate synthase DhbC; Validated; Region: PRK06923 260799006022 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 260799006023 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 260799006024 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 260799006025 acyl-activating enzyme (AAE) consensus motif; other site 260799006026 active site 260799006027 AMP binding site [chemical binding]; other site 260799006028 substrate binding site [chemical binding]; other site 260799006029 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 260799006030 catalytic triad [active] 260799006031 conserved cis-peptide bond; other site 260799006032 Phosphopantetheine attachment site; Region: PP-binding; cl09936 260799006033 Condensation domain; Region: Condensation; cl19241 260799006034 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 260799006035 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 260799006036 acyl-activating enzyme (AAE) consensus motif; other site 260799006037 AMP binding site [chemical binding]; other site 260799006038 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 260799006039 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 260799006040 Condensation domain; Region: Condensation; pfam00668 260799006041 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 260799006042 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 260799006043 acyl-activating enzyme (AAE) consensus motif; other site 260799006044 AMP binding site [chemical binding]; other site 260799006045 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 260799006046 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 260799006047 MbtH-like protein; Region: MbtH; pfam03621 260799006048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799006049 putative transporter; Provisional; Region: PRK10504 260799006050 putative substrate translocation pore; other site 260799006051 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 260799006052 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 260799006053 Chorismate lyase; Region: Chor_lyase; cl01230 260799006054 histone-like DNA-binding protein HU; Region: HU; cd13831 260799006055 dimer interface [polypeptide binding]; other site 260799006056 DNA binding site [nucleotide binding] 260799006057 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 260799006058 DinB family; Region: DinB; cl17821 260799006059 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 260799006060 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 260799006061 Subtilase family; Region: Peptidase_S8; pfam00082 260799006062 active site 260799006063 catalytic triad [active] 260799006064 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 260799006065 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 260799006066 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 260799006067 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 260799006068 RNA binding surface [nucleotide binding]; other site 260799006069 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 260799006070 probable active site [active] 260799006071 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 260799006072 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 260799006073 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 260799006074 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 260799006075 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 260799006076 active site 260799006077 dimer interface [polypeptide binding]; other site 260799006078 motif 1; other site 260799006079 motif 2; other site 260799006080 motif 3; other site 260799006081 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 260799006082 anticodon binding site; other site 260799006083 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 260799006084 FtsX-like permease family; Region: FtsX; pfam02687 260799006085 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 260799006086 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799006087 H+ Antiporter protein; Region: 2A0121; TIGR00900 260799006088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799006089 putative substrate translocation pore; other site 260799006090 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 260799006091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799006092 dimer interface [polypeptide binding]; other site 260799006093 conserved gate region; other site 260799006094 ABC-ATPase subunit interface; other site 260799006095 ZIP Zinc transporter; Region: Zip; cl00437 260799006096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799006097 S-adenosylmethionine binding site [chemical binding]; other site 260799006098 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; cl19625 260799006099 Protein of unknown function (DUF2185); Region: DUF2185; pfam09951 260799006100 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 260799006101 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 260799006102 active site 260799006103 dimerization interface [polypeptide binding]; other site 260799006104 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 260799006105 multidrug resistance protein (mdr1); Provisional; Region: PTZ00265 260799006106 Bacterial PH domain; Region: bPH_3; pfam14470 260799006107 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799006108 Coenzyme A binding pocket [chemical binding]; other site 260799006109 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 260799006110 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799006111 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799006112 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 260799006113 Transport protein; Region: actII; TIGR00833 260799006114 MMPL family; Region: MMPL; cl14618 260799006115 MMPL family; Region: MMPL; cl14618 260799006116 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 260799006117 Chloramphenicol acetyltransferase; Region: CAT; pfam00302 260799006118 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799006119 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 260799006120 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 260799006121 Coenzyme A binding pocket [chemical binding]; other site 260799006122 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 260799006123 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799006124 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 260799006125 Coenzyme A binding pocket [chemical binding]; other site 260799006126 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 260799006127 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 260799006128 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 260799006129 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799006130 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799006131 Coenzyme A binding pocket [chemical binding]; other site 260799006132 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 260799006133 EamA-like transporter family; Region: EamA; pfam00892 260799006134 EamA-like transporter family; Region: EamA; pfam00892 260799006135 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 260799006136 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799006137 non-specific DNA binding site [nucleotide binding]; other site 260799006138 salt bridge; other site 260799006139 sequence-specific DNA binding site [nucleotide binding]; other site 260799006140 Cupin domain; Region: Cupin_2; pfam07883 260799006141 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799006142 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 260799006143 protoporphyrinogen oxidase; Provisional; Region: PRK12416 260799006144 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 260799006145 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 260799006146 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799006147 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 260799006148 Cold-inducible protein YdjO; Region: YdjO; pfam14169 260799006149 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 260799006150 DNA-binding site [nucleotide binding]; DNA binding site 260799006151 RNA-binding motif; other site 260799006152 AAA domain; Region: AAA_18; pfam13238 260799006153 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 260799006154 active site 260799006155 metal binding site [ion binding]; metal-binding site 260799006156 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799006157 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 260799006158 active site 260799006159 motif I; other site 260799006160 motif II; other site 260799006161 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 260799006162 hypothetical protein; Provisional; Region: PRK06770 260799006163 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 260799006164 Transcriptional regulator [Transcription]; Region: LysR; COG0583 260799006165 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 260799006166 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 260799006167 dimerization interface [polypeptide binding]; other site 260799006168 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 260799006169 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 260799006170 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 260799006171 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 260799006172 active site 260799006173 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 260799006174 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 260799006175 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 260799006176 dimerization interface [polypeptide binding]; other site 260799006177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 260799006178 MOSC domain; Region: MOSC; pfam03473 260799006179 3-alpha domain; Region: 3-alpha; pfam03475 260799006180 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799006181 Coenzyme A binding pocket [chemical binding]; other site 260799006182 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 260799006183 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 260799006184 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 260799006185 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 260799006186 Walker A/P-loop; other site 260799006187 ATP binding site [chemical binding]; other site 260799006188 Q-loop/lid; other site 260799006189 ABC transporter signature motif; other site 260799006190 Walker B; other site 260799006191 D-loop; other site 260799006192 H-loop/switch region; other site 260799006193 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 260799006194 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 260799006195 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 260799006196 Walker A/P-loop; other site 260799006197 ATP binding site [chemical binding]; other site 260799006198 Q-loop/lid; other site 260799006199 ABC transporter signature motif; other site 260799006200 Walker B; other site 260799006201 D-loop; other site 260799006202 H-loop/switch region; other site 260799006203 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 260799006204 active site 260799006205 metal binding site [ion binding]; metal-binding site 260799006206 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 260799006207 LysE type translocator; Region: LysE; cl00565 260799006208 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 260799006209 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799006210 non-specific DNA binding site [nucleotide binding]; other site 260799006211 salt bridge; other site 260799006212 sequence-specific DNA binding site [nucleotide binding]; other site 260799006213 Cupin domain; Region: Cupin_2; pfam07883 260799006214 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 260799006215 exosporium leader peptide; Region: exospor_lead; TIGR03720 260799006216 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 260799006217 BclB C-terminal domain; Region: exospore_TM; TIGR03721 260799006218 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 260799006219 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 260799006220 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 260799006221 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799006222 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 260799006223 DNA binding residues [nucleotide binding] 260799006224 Methyltransferase domain; Region: Methyltransf_31; pfam13847 260799006225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799006226 S-adenosylmethionine binding site [chemical binding]; other site 260799006227 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 260799006228 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 260799006229 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 260799006230 Glycosyl hydrolase like GH101; Region: DUF187; pfam02638 260799006231 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 260799006232 active site 260799006233 P-loop; other site 260799006234 phosphorylation site [posttranslational modification] 260799006235 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 260799006236 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 260799006237 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 260799006238 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 260799006239 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 260799006240 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 260799006241 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 260799006242 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 260799006243 catalytic residue [active] 260799006244 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 260799006245 tetramer interface [polypeptide binding]; other site 260799006246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799006247 catalytic residue [active] 260799006248 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 260799006249 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 260799006250 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 260799006251 ATP binding site [chemical binding]; other site 260799006252 Mg++ binding site [ion binding]; other site 260799006253 motif III; other site 260799006254 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 260799006255 nucleotide binding region [chemical binding]; other site 260799006256 ATP-binding site [chemical binding]; other site 260799006257 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799006258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799006259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799006260 H+ Antiporter protein; Region: 2A0121; TIGR00900 260799006261 putative substrate translocation pore; other site 260799006262 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 260799006263 FtsX-like permease family; Region: FtsX; pfam02687 260799006264 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 260799006265 FtsX-like permease family; Region: FtsX; pfam02687 260799006266 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 260799006267 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 260799006268 Walker A/P-loop; other site 260799006269 ATP binding site [chemical binding]; other site 260799006270 Q-loop/lid; other site 260799006271 ABC transporter signature motif; other site 260799006272 Walker B; other site 260799006273 D-loop; other site 260799006274 H-loop/switch region; other site 260799006275 Methyltransferase domain; Region: Methyltransf_31; pfam13847 260799006276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799006277 S-adenosylmethionine binding site [chemical binding]; other site 260799006278 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 260799006279 dimer interface [polypeptide binding]; other site 260799006280 Methyltransferase domain; Region: Methyltransf_31; pfam13847 260799006281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799006282 S-adenosylmethionine binding site [chemical binding]; other site 260799006283 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 260799006284 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 260799006285 dimer interface [polypeptide binding]; other site 260799006286 PYR/PP interface [polypeptide binding]; other site 260799006287 TPP binding site [chemical binding]; other site 260799006288 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 260799006289 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 260799006290 TPP-binding site [chemical binding]; other site 260799006291 dimer interface [polypeptide binding]; other site 260799006292 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 260799006293 Transcriptional regulators [Transcription]; Region: MarR; COG1846 260799006294 putative DNA binding site [nucleotide binding]; other site 260799006295 putative Zn2+ binding site [ion binding]; other site 260799006296 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 260799006297 catalytic core [active] 260799006298 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 260799006299 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 260799006300 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 260799006301 metal binding site [ion binding]; metal-binding site 260799006302 dimer interface [polypeptide binding]; other site 260799006303 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 260799006304 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799006305 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 260799006306 DNA binding residues [nucleotide binding] 260799006307 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 260799006308 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 260799006309 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 260799006310 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 260799006311 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 260799006312 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 260799006313 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 260799006314 active site 260799006315 Transcriptional regulators [Transcription]; Region: PurR; COG1609 260799006316 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 260799006317 DNA binding site [nucleotide binding] 260799006318 domain linker motif; other site 260799006319 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 260799006320 ligand binding site [chemical binding]; other site 260799006321 dimerization interface [polypeptide binding]; other site 260799006322 polyol permease family; Region: 2A0118; TIGR00897 260799006323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799006324 putative substrate translocation pore; other site 260799006325 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 260799006326 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 260799006327 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 260799006328 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 260799006329 substrate binding site [chemical binding]; other site 260799006330 ATP binding site [chemical binding]; other site 260799006331 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 260799006332 tetrameric interface [polypeptide binding]; other site 260799006333 NAD binding site [chemical binding]; other site 260799006334 catalytic residues [active] 260799006335 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 260799006336 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 260799006337 PYR/PP interface [polypeptide binding]; other site 260799006338 dimer interface [polypeptide binding]; other site 260799006339 TPP binding site [chemical binding]; other site 260799006340 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 260799006341 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 260799006342 TPP-binding site; other site 260799006343 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 260799006344 intersubunit interface [polypeptide binding]; other site 260799006345 active site 260799006346 zinc binding site [ion binding]; other site 260799006347 Na+ binding site [ion binding]; other site 260799006348 KduI/IolB family; Region: KduI; pfam04962 260799006349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799006350 TPR motif; other site 260799006351 binding surface 260799006352 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 260799006353 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799006354 salt bridge; other site 260799006355 non-specific DNA binding site [nucleotide binding]; other site 260799006356 sequence-specific DNA binding site [nucleotide binding]; other site 260799006357 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 260799006358 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 260799006359 S-layer homology domain; Region: SLH; pfam00395 260799006360 S-layer homology domain; Region: SLH; pfam00395 260799006361 S-layer homology domain; Region: SLH; pfam00395 260799006362 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 260799006363 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 260799006364 active site 260799006365 metal binding site [ion binding]; metal-binding site 260799006366 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799006367 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799006368 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 260799006369 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 260799006370 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 260799006371 PAS domain; Region: PAS_9; pfam13426 260799006372 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 260799006373 putative active site [active] 260799006374 heme pocket [chemical binding]; other site 260799006375 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 260799006376 metal binding site [ion binding]; metal-binding site 260799006377 active site 260799006378 I-site; other site 260799006379 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 260799006380 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799006381 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 260799006382 SMI1-KNR4 cell-wall; Region: SUKH_6; pfam14568 260799006383 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 260799006384 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 260799006385 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 260799006386 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 260799006387 active site residue [active] 260799006388 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 260799006389 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 260799006390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 260799006391 Walker A/P-loop; other site 260799006392 ATP binding site [chemical binding]; other site 260799006393 Q-loop/lid; other site 260799006394 ABC transporter signature motif; other site 260799006395 Walker B; other site 260799006396 D-loop; other site 260799006397 H-loop/switch region; other site 260799006398 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 260799006399 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 260799006400 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799006401 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799006402 Protein of unknown function (DUF523); Region: DUF523; pfam04463 260799006403 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 260799006404 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 260799006405 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 260799006406 FAD binding site [chemical binding]; other site 260799006407 homotetramer interface [polypeptide binding]; other site 260799006408 substrate binding pocket [chemical binding]; other site 260799006409 catalytic base [active] 260799006410 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 260799006411 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 260799006412 ATP-grasp domain; Region: ATP-grasp_4; cl17255 260799006413 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 260799006414 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 260799006415 carboxyltransferase (CT) interaction site; other site 260799006416 biotinylation site [posttranslational modification]; other site 260799006417 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 260799006418 active site 260799006419 catalytic residues [active] 260799006420 metal binding site [ion binding]; metal-binding site 260799006421 enoyl-CoA hydratase; Provisional; Region: PRK07657 260799006422 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 260799006423 substrate binding site [chemical binding]; other site 260799006424 oxyanion hole (OAH) forming residues; other site 260799006425 trimer interface [polypeptide binding]; other site 260799006426 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 260799006427 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 260799006428 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 260799006429 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 260799006430 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 260799006431 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 260799006432 acyl-activating enzyme (AAE) consensus motif; other site 260799006433 putative AMP binding site [chemical binding]; other site 260799006434 putative active site [active] 260799006435 putative CoA binding site [chemical binding]; other site 260799006436 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 260799006437 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799006438 Coenzyme A binding pocket [chemical binding]; other site 260799006439 hypothetical protein; Provisional; Region: PRK08233 260799006440 active site 260799006441 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799006442 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 260799006443 DinB family; Region: DinB; cl17821 260799006444 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799006445 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799006446 dimer interface [polypeptide binding]; other site 260799006447 phosphorylation site [posttranslational modification] 260799006448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799006449 ATP binding site [chemical binding]; other site 260799006450 Mg2+ binding site [ion binding]; other site 260799006451 G-X-G motif; other site 260799006452 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799006453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799006454 active site 260799006455 phosphorylation site [posttranslational modification] 260799006456 intermolecular recognition site; other site 260799006457 dimerization interface [polypeptide binding]; other site 260799006458 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799006459 DNA binding site [nucleotide binding] 260799006460 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 260799006461 Zn2+ binding site [ion binding]; other site 260799006462 Mg2+ binding site [ion binding]; other site 260799006463 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 260799006464 S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714 260799006465 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 260799006466 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 260799006467 NAD binding site [chemical binding]; other site 260799006468 substrate binding site [chemical binding]; other site 260799006469 putative active site [active] 260799006470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799006471 Coenzyme A binding pocket [chemical binding]; other site 260799006472 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 260799006473 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799006474 Coenzyme A binding pocket [chemical binding]; other site 260799006475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 260799006476 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 260799006477 putative hydrophobic ligand binding site [chemical binding]; other site 260799006478 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 260799006479 Walker A/P-loop; other site 260799006480 ATP binding site [chemical binding]; other site 260799006481 Q-loop/lid; other site 260799006482 ABC transporter signature motif; other site 260799006483 Walker B; other site 260799006484 D-loop; other site 260799006485 H-loop/switch region; other site 260799006486 ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238 260799006487 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 260799006488 AAA domain; Region: AAA_22; pfam13401 260799006489 Predicted transcriptional regulators [Transcription]; Region: COG1695 260799006490 Beta-lactamase; Region: Beta-lactamase; pfam00144 260799006491 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 260799006492 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 260799006493 DNA binding residues [nucleotide binding] 260799006494 drug binding residues [chemical binding]; other site 260799006495 dimer interface [polypeptide binding]; other site 260799006496 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 260799006497 H+ Antiporter protein; Region: 2A0121; TIGR00900 260799006498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799006499 putative substrate translocation pore; other site 260799006500 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 260799006501 nudix motif; other site 260799006502 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 260799006503 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 260799006504 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 260799006505 active site 260799006506 substrate binding site [chemical binding]; other site 260799006507 Phosphotransferase enzyme family; Region: APH; pfam01636 260799006508 ATP binding site [chemical binding]; other site 260799006509 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 260799006510 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 260799006511 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 260799006512 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 260799006513 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 260799006514 active site 260799006515 Zn binding site [ion binding]; other site 260799006516 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 260799006517 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 260799006518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 260799006519 DNA-binding site [nucleotide binding]; DNA binding site 260799006520 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 260799006521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799006522 homodimer interface [polypeptide binding]; other site 260799006523 catalytic residue [active] 260799006524 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 260799006525 Alcohol dehydrogenase GroES-like domain; Region: ADH_N; pfam08240 260799006526 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 260799006527 putative NAD(P) binding site [chemical binding]; other site 260799006528 Methyltransferase domain; Region: Methyltransf_31; pfam13847 260799006529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799006530 S-adenosylmethionine binding site [chemical binding]; other site 260799006531 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 260799006532 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 260799006533 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 260799006534 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 260799006535 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 260799006536 Methyltransferase domain; Region: Methyltransf_31; pfam13847 260799006537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799006538 S-adenosylmethionine binding site [chemical binding]; other site 260799006539 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 260799006540 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 260799006541 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799006542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799006543 active site 260799006544 phosphorylation site [posttranslational modification] 260799006545 intermolecular recognition site; other site 260799006546 dimerization interface [polypeptide binding]; other site 260799006547 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799006548 DNA binding site [nucleotide binding] 260799006549 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 260799006550 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 260799006551 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 260799006552 ABC transporter; Region: ABC_tran_2; pfam12848 260799006553 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 260799006554 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 260799006555 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799006556 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 260799006557 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 260799006558 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 260799006559 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 260799006560 Walker A/P-loop; other site 260799006561 ATP binding site [chemical binding]; other site 260799006562 Q-loop/lid; other site 260799006563 ABC transporter signature motif; other site 260799006564 Walker B; other site 260799006565 D-loop; other site 260799006566 H-loop/switch region; other site 260799006567 hypothetical protein; Provisional; Region: PRK06760 260799006568 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 260799006569 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799006570 homoserine dehydrogenase; Validated; Region: PRK06813 260799006571 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 260799006572 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 260799006573 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 260799006574 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 260799006575 DNA-binding site [nucleotide binding]; DNA binding site 260799006576 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 260799006577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799006578 homodimer interface [polypeptide binding]; other site 260799006579 catalytic residue [active] 260799006580 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 260799006581 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 260799006582 ATP-grasp domain; Region: ATP-grasp_4; cl17255 260799006583 Putative transcription activator [Transcription]; Region: TenA; COG0819 260799006584 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 260799006585 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 260799006586 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 260799006587 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 260799006588 Protein of unknown function; Region: DUF3658; pfam12395 260799006589 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 260799006590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799006591 H+ Antiporter protein; Region: 2A0121; TIGR00900 260799006592 putative substrate translocation pore; other site 260799006593 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 260799006594 trimer interface [polypeptide binding]; other site 260799006595 active site 260799006596 substrate binding site [chemical binding]; other site 260799006597 CoA binding site [chemical binding]; other site 260799006598 Predicted transcriptional regulators [Transcription]; Region: COG1695 260799006599 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 260799006600 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 260799006601 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 260799006602 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799006603 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 260799006604 active site 260799006605 motif I; other site 260799006606 motif II; other site 260799006607 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 260799006608 PAS domain S-box; Region: sensory_box; TIGR00229 260799006609 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 260799006610 putative active site [active] 260799006611 heme pocket [chemical binding]; other site 260799006612 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 260799006613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799006614 dimer interface [polypeptide binding]; other site 260799006615 phosphorylation site [posttranslational modification] 260799006616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799006617 ATP binding site [chemical binding]; other site 260799006618 Mg2+ binding site [ion binding]; other site 260799006619 G-X-G motif; other site 260799006620 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 260799006621 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 260799006622 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 260799006623 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 260799006624 glycosyltransferase, MGT family; Region: MGT; TIGR01426 260799006625 active site 260799006626 TDP-binding site; other site 260799006627 acceptor substrate-binding pocket; other site 260799006628 homodimer interface [polypeptide binding]; other site 260799006629 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 260799006630 hypothetical protein; Provisional; Region: PRK13661 260799006631 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 260799006632 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 260799006633 Walker A/P-loop; other site 260799006634 ATP binding site [chemical binding]; other site 260799006635 Q-loop/lid; other site 260799006636 ABC transporter signature motif; other site 260799006637 Walker B; other site 260799006638 D-loop; other site 260799006639 H-loop/switch region; other site 260799006640 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 260799006641 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 260799006642 Walker A/P-loop; other site 260799006643 ATP binding site [chemical binding]; other site 260799006644 Q-loop/lid; other site 260799006645 ABC transporter signature motif; other site 260799006646 Walker B; other site 260799006647 D-loop; other site 260799006648 H-loop/switch region; other site 260799006649 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 260799006650 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 260799006651 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799006652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799006653 dimer interface [polypeptide binding]; other site 260799006654 phosphorylation site [posttranslational modification] 260799006655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799006656 ATP binding site [chemical binding]; other site 260799006657 Mg2+ binding site [ion binding]; other site 260799006658 G-X-G motif; other site 260799006659 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 260799006660 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 260799006661 active site 260799006662 ATP binding site [chemical binding]; other site 260799006663 substrate binding site [chemical binding]; other site 260799006664 activation loop (A-loop); other site 260799006665 GrpB protein; Region: GrpB; pfam04229 260799006666 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 260799006667 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 260799006668 NAD(P) binding site [chemical binding]; other site 260799006669 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 260799006670 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 260799006671 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 260799006672 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 260799006673 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 260799006674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799006675 H+ Antiporter protein; Region: 2A0121; TIGR00900 260799006676 putative substrate translocation pore; other site 260799006677 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 260799006678 putative acetyltransferase; Provisional; Region: PRK03624 260799006679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799006680 Coenzyme A binding pocket [chemical binding]; other site 260799006681 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 260799006682 EDD domain protein, DegV family; Region: DegV; TIGR00762 260799006683 DJ-1 family protein; Region: not_thiJ; TIGR01383 260799006684 Putative amidotransferase; Region: DUF4066; pfam13278 260799006685 conserved cys residue [active] 260799006686 Predicted transcriptional regulator [Transcription]; Region: COG2378 260799006687 HTH domain; Region: HTH_11; pfam08279 260799006688 WYL domain; Region: WYL; pfam13280 260799006689 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 260799006690 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 260799006691 conserved cys residue [active] 260799006692 Protein of unknown function (DUF975); Region: DUF975; cl10504 260799006693 Beta-lactamase; Region: Beta-lactamase; pfam00144 260799006694 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 260799006695 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777 260799006696 DNA binding residues [nucleotide binding] 260799006697 putative dimer interface [polypeptide binding]; other site 260799006698 Trm112p-like protein; Region: Trm112p; pfam03966 260799006699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799006700 S-adenosylmethionine binding site [chemical binding]; other site 260799006701 H+ Antiporter protein; Region: 2A0121; TIGR00900 260799006702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799006703 putative substrate translocation pore; other site 260799006704 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799006705 Coenzyme A binding pocket [chemical binding]; other site 260799006706 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 260799006707 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 260799006708 active site 260799006709 catalytic site [active] 260799006710 metal binding site [ion binding]; metal-binding site 260799006711 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 260799006712 EamA-like transporter family; Region: EamA; pfam00892 260799006713 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 260799006714 EamA-like transporter family; Region: EamA; pfam00892 260799006715 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 260799006716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799006717 Coenzyme A binding pocket [chemical binding]; other site 260799006718 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 260799006719 nudix motif; other site 260799006720 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 260799006721 Beta-lactamase; Region: Beta-lactamase; pfam00144 260799006722 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 260799006723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799006724 putative substrate translocation pore; other site 260799006725 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 260799006726 nudix motif; other site 260799006727 DNA polymerase III subunit beta; Validated; Region: PRK06673 260799006728 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 260799006729 putative DNA binding surface [nucleotide binding]; other site 260799006730 dimer interface [polypeptide binding]; other site 260799006731 beta-clamp/clamp loader binding surface; other site 260799006732 beta-clamp/translesion DNA polymerase binding surface; other site 260799006733 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 260799006734 putative active site [active] 260799006735 nucleotide binding site [chemical binding]; other site 260799006736 nudix motif; other site 260799006737 putative metal binding site [ion binding]; other site 260799006738 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 260799006739 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 260799006740 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799006741 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 260799006742 LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528 260799006743 LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528 260799006744 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 260799006745 homotrimer interaction site [polypeptide binding]; other site 260799006746 putative active site [active] 260799006747 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 260799006748 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 260799006749 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 260799006750 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 260799006751 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 260799006752 YxiJ-like protein; Region: YxiJ; pfam14176 260799006753 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 260799006754 pentamer interface [polypeptide binding]; other site 260799006755 dodecaamer interface [polypeptide binding]; other site 260799006756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799006757 Coenzyme A binding pocket [chemical binding]; other site 260799006758 metal-dependent hydrolase; Provisional; Region: PRK13291 260799006759 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799006760 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 260799006761 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 260799006762 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 260799006763 GIY-YIG motif/motif A; other site 260799006764 active site 260799006765 catalytic site [active] 260799006766 putative DNA binding site [nucleotide binding]; other site 260799006767 metal binding site [ion binding]; metal-binding site 260799006768 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799006769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799006770 Coenzyme A binding pocket [chemical binding]; other site 260799006771 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 260799006772 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 260799006773 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 260799006774 active site 260799006775 ATP binding site [chemical binding]; other site 260799006776 substrate binding site [chemical binding]; other site 260799006777 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 260799006778 nudix motif; other site 260799006779 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 260799006780 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 260799006781 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 260799006782 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 260799006783 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 260799006784 MepB protein; Region: MepB; pfam08877 260799006785 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 260799006786 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 260799006787 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 260799006788 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799006789 motif II; other site 260799006790 DinB superfamily; Region: DinB_2; pfam12867 260799006791 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 260799006792 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 260799006793 catalytic residue [active] 260799006794 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 260799006795 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 260799006796 acyl-activating enzyme (AAE) consensus motif; other site 260799006797 AMP binding site [chemical binding]; other site 260799006798 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 260799006799 Condensation domain; Region: Condensation; cl19241 260799006800 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 260799006801 Nonribosomal peptide synthase; Region: NRPS; pfam08415 260799006802 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 260799006803 acyl-activating enzyme (AAE) consensus motif; other site 260799006804 AMP binding site [chemical binding]; other site 260799006805 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 260799006806 Condensation domain; Region: Condensation; pfam00668 260799006807 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 260799006808 putative FMN binding site [chemical binding]; other site 260799006809 NADPH bind site [chemical binding]; other site 260799006810 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 260799006811 carbohydrate binding site [chemical binding]; other site 260799006812 pullulanase, type I; Region: pulA_typeI; TIGR02104 260799006813 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 260799006814 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 260799006815 Ca binding site [ion binding]; other site 260799006816 active site 260799006817 catalytic site [active] 260799006818 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 260799006819 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 260799006820 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 260799006821 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 260799006822 active site 260799006823 Zn binding site [ion binding]; other site 260799006824 Putative zinc-finger; Region: zf-HC2; pfam13490 260799006825 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 260799006826 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 260799006827 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799006828 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 260799006829 DNA binding residues [nucleotide binding] 260799006830 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 260799006831 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 260799006832 SecY translocase; Region: SecY; pfam00344 260799006833 hypothetical protein; Validated; Region: PRK06672 260799006834 DnaA N-terminal domain; Region: DnaA_N; pfam11638 260799006835 DnaA N-terminal domain; Region: DnaA_N; pfam11638 260799006836 DnaA N-terminal domain; Region: DnaA_N; pfam11638 260799006837 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 260799006838 EamA-like transporter family; Region: EamA; pfam00892 260799006839 EamA-like transporter family; Region: EamA; pfam00892 260799006840 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 260799006841 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 260799006842 DNA-binding site [nucleotide binding]; DNA binding site 260799006843 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 260799006844 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799006845 homodimer interface [polypeptide binding]; other site 260799006846 catalytic residue [active] 260799006847 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 260799006848 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799006849 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 260799006850 Mg binding site [ion binding]; other site 260799006851 nucleotide binding site [chemical binding]; other site 260799006852 putative protofilament interface [polypeptide binding]; other site 260799006853 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 260799006854 Predicted membrane protein [Function unknown]; Region: COG4129 260799006855 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 260799006856 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 260799006857 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 260799006858 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 260799006859 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 260799006860 germination protein YpeB; Region: spore_YpeB; TIGR02889 260799006861 YpeB sporulation; Region: YPEB; pfam14620 260799006862 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 260799006863 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 260799006864 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 260799006865 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 260799006866 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 260799006867 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 260799006868 arylformamidase; Region: trp_arylform; TIGR03035 260799006869 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 260799006870 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 260799006871 catalytic residue [active] 260799006872 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799006873 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799006874 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 260799006875 nudix motif; other site 260799006876 N-acetyltransferase; Region: Acetyltransf_2; cl00949 260799006877 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 260799006878 hydrophobic ligand binding site; other site 260799006879 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 260799006880 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 260799006881 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 260799006882 GAF domain; Region: GAF; pfam01590 260799006883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799006884 Walker A motif; other site 260799006885 ATP binding site [chemical binding]; other site 260799006886 Walker B motif; other site 260799006887 arginine finger; other site 260799006888 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 260799006889 NIPSNAP; Region: NIPSNAP; pfam07978 260799006890 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 260799006891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799006892 Coenzyme A binding pocket [chemical binding]; other site 260799006893 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 260799006894 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 260799006895 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 260799006896 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 260799006897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799006898 S-adenosylmethionine binding site [chemical binding]; other site 260799006899 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 260799006900 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 260799006901 Predicted transcriptional regulator [Transcription]; Region: COG1959 260799006902 Rrf2 family protein; Region: rrf2_super; TIGR00738 260799006903 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 260799006904 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 260799006905 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 260799006906 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 260799006907 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 260799006908 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 260799006909 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 260799006910 E3 interaction surface; other site 260799006911 lipoyl attachment site [posttranslational modification]; other site 260799006912 e3 binding domain; Region: E3_binding; pfam02817 260799006913 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 260799006914 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 260799006915 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 260799006916 alpha subunit interface [polypeptide binding]; other site 260799006917 TPP binding site [chemical binding]; other site 260799006918 heterodimer interface [polypeptide binding]; other site 260799006919 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 260799006920 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 260799006921 tetramer interface [polypeptide binding]; other site 260799006922 TPP-binding site [chemical binding]; other site 260799006923 heterodimer interface [polypeptide binding]; other site 260799006924 phosphorylation loop region [posttranslational modification] 260799006925 DinB superfamily; Region: DinB_2; pfam12867 260799006926 short chain dehydrogenase; Provisional; Region: PRK06914 260799006927 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 260799006928 NADP binding site [chemical binding]; other site 260799006929 active site 260799006930 steroid binding site; other site 260799006931 GrpB protein; Region: GrpB; pfam04229 260799006932 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 260799006933 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 260799006934 nudix motif; other site 260799006935 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 260799006936 Protein phosphatase 2C; Region: PP2C_2; pfam13672 260799006937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799006938 dimer interface [polypeptide binding]; other site 260799006939 conserved gate region; other site 260799006940 putative PBP binding loops; other site 260799006941 ABC-ATPase subunit interface; other site 260799006942 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 260799006943 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 260799006944 Walker A/P-loop; other site 260799006945 ATP binding site [chemical binding]; other site 260799006946 Q-loop/lid; other site 260799006947 ABC transporter signature motif; other site 260799006948 Walker B; other site 260799006949 D-loop; other site 260799006950 H-loop/switch region; other site 260799006951 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 260799006952 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 260799006953 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 260799006954 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 260799006955 oligomer interface [polypeptide binding]; other site 260799006956 active site residues [active] 260799006957 RNA polymerase factor sigma-70; Validated; Region: PRK06704 260799006958 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799006959 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 260799006960 DNA binding residues [nucleotide binding] 260799006961 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 260799006962 catalytic loop [active] 260799006963 iron binding site [ion binding]; other site 260799006964 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 260799006965 tetramer (dimer of dimers) interface [polypeptide binding]; other site 260799006966 active site 260799006967 dimer interface [polypeptide binding]; other site 260799006968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799006969 Coenzyme A binding pocket [chemical binding]; other site 260799006970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 260799006971 Chitin binding domain; Region: Chitin_bind_3; pfam03067 260799006972 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 260799006973 Interdomain contacts; other site 260799006974 Cytokine receptor motif; other site 260799006975 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 260799006976 Interdomain contacts; other site 260799006977 Cytokine receptor motif; other site 260799006978 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 260799006979 topology modulation protein; Reviewed; Region: PRK08118 260799006980 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 260799006981 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 260799006982 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 260799006983 Protein of unknown function; Region: DUF3658; pfam12395 260799006984 YjbR; Region: YjbR; pfam04237 260799006985 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799006986 Coenzyme A binding pocket [chemical binding]; other site 260799006987 S-layer homology domain; Region: SLH; pfam00395 260799006988 S-layer homology domain; Region: SLH; pfam00395 260799006989 S-layer homology domain; Region: SLH; pfam00395 260799006990 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 260799006991 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 260799006992 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 260799006993 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 260799006994 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 260799006995 active site 260799006996 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 260799006997 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799006998 Coenzyme A binding pocket [chemical binding]; other site 260799006999 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 260799007000 Predicted transcriptional regulators [Transcription]; Region: COG1695 260799007001 Protein of unknown function (DUF952); Region: DUF952; pfam06108 260799007002 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 260799007003 Part of AAA domain; Region: AAA_19; pfam13245 260799007004 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 260799007005 Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449 260799007006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799007007 S-adenosylmethionine binding site [chemical binding]; other site 260799007008 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 260799007009 putative active site pocket [active] 260799007010 dimerization interface [polypeptide binding]; other site 260799007011 putative catalytic residue [active] 260799007012 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 260799007013 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 260799007014 ATP binding site [chemical binding]; other site 260799007015 putative Mg++ binding site [ion binding]; other site 260799007016 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 260799007017 nucleotide binding region [chemical binding]; other site 260799007018 ATP-binding site [chemical binding]; other site 260799007019 RQC domain; Region: RQC; pfam09382 260799007020 HRDC domain; Region: HRDC; pfam00570 260799007021 Helix-turn-helix domain; Region: HTH_40; pfam14493 260799007022 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 260799007023 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 260799007024 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 260799007025 active site 260799007026 Zn binding site [ion binding]; other site 260799007027 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 260799007028 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 260799007029 DHHA2 domain; Region: DHHA2; pfam02833 260799007030 Chitin binding domain; Region: Chitin_bind_3; pfam03067 260799007031 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 260799007032 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799007033 Coenzyme A binding pocket [chemical binding]; other site 260799007034 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 260799007035 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 260799007036 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 260799007037 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 260799007038 NAD(P) binding site [chemical binding]; other site 260799007039 catalytic residues [active] 260799007040 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 260799007041 inhibitor site; inhibition site 260799007042 active site 260799007043 dimer interface [polypeptide binding]; other site 260799007044 catalytic residue [active] 260799007045 Proline racemase; Region: Pro_racemase; pfam05544 260799007046 hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687 260799007047 hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687 260799007048 Proline racemase; Region: Pro_racemase; pfam05544 260799007049 FAD dependent oxidoreductase; Region: DAO; pfam01266 260799007050 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 260799007051 PAS domain; Region: PAS; smart00091 260799007052 PAS domain; Region: PAS_9; pfam13426 260799007053 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 260799007054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799007055 Walker A motif; other site 260799007056 ATP binding site [chemical binding]; other site 260799007057 Walker B motif; other site 260799007058 arginine finger; other site 260799007059 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 260799007060 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 260799007061 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 260799007062 catalytic loop [active] 260799007063 iron binding site [ion binding]; other site 260799007064 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 260799007065 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 260799007066 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 260799007067 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 260799007068 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 260799007069 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 260799007070 DltD N-terminal region; Region: DltD_N; pfam04915 260799007071 DltD central region; Region: DltD_M; pfam04918 260799007072 DltD C-terminal region; Region: DltD_C; pfam04914 260799007073 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799007074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799007075 Coenzyme A binding pocket [chemical binding]; other site 260799007076 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 260799007077 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 260799007078 peptide binding site [polypeptide binding]; other site 260799007079 Bacterial SH3 domain; Region: SH3_3; pfam08239 260799007080 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 260799007081 NlpC/P60 family; Region: NLPC_P60; pfam00877 260799007082 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 260799007083 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 260799007084 active site 260799007085 Septum formation initiator; Region: DivIC; pfam04977 260799007086 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 260799007087 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 260799007088 active site 260799007089 catalytic motif [active] 260799007090 Zn binding site [ion binding]; other site 260799007091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799007092 S-adenosylmethionine binding site [chemical binding]; other site 260799007093 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 260799007094 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 260799007095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 260799007096 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799007097 dimerization interface [polypeptide binding]; other site 260799007098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799007099 dimer interface [polypeptide binding]; other site 260799007100 phosphorylation site [posttranslational modification] 260799007101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799007102 ATP binding site [chemical binding]; other site 260799007103 Mg2+ binding site [ion binding]; other site 260799007104 G-X-G motif; other site 260799007105 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 260799007106 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Validated; Region: PRK06698 260799007107 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Provisional; Region: PRK14697 260799007108 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 260799007109 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799007110 motif II; other site 260799007111 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 260799007112 Phosphotransferase enzyme family; Region: APH; pfam01636 260799007113 active site 260799007114 substrate binding site [chemical binding]; other site 260799007115 ATP binding site [chemical binding]; other site 260799007116 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 260799007117 EDD domain protein, DegV family; Region: DegV; TIGR00762 260799007118 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799007119 Coenzyme A binding pocket [chemical binding]; other site 260799007120 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 260799007121 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 260799007122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799007123 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799007124 putative substrate translocation pore; other site 260799007125 Protein of unknown function (DUF342); Region: DUF342; cl19219 260799007126 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 260799007127 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 260799007128 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 260799007129 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 260799007130 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 260799007131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799007132 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799007133 putative substrate translocation pore; other site 260799007134 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 260799007135 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 260799007136 Predicted membrane protein [Function unknown]; Region: COG2261 260799007137 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 260799007138 active site 260799007139 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 260799007140 Methyltransferase domain; Region: Methyltransf_31; pfam13847 260799007141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799007142 S-adenosylmethionine binding site [chemical binding]; other site 260799007143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799007144 putative substrate translocation pore; other site 260799007145 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799007146 aspartate aminotransferase; Provisional; Region: PRK07681 260799007147 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 260799007148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799007149 homodimer interface [polypeptide binding]; other site 260799007150 catalytic residue [active] 260799007151 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 260799007152 pantothenate kinase; Provisional; Region: PRK13317 260799007153 CAAX protease self-immunity; Region: Abi; pfam02517 260799007154 Protein of unknown function (DUF4052); Region: DUF4052; pfam13261 260799007155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 260799007156 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 260799007157 Walker A/P-loop; other site 260799007158 ATP binding site [chemical binding]; other site 260799007159 Q-loop/lid; other site 260799007160 ABC transporter signature motif; other site 260799007161 Walker B; other site 260799007162 D-loop; other site 260799007163 H-loop/switch region; other site 260799007164 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 260799007165 DNA-binding site [nucleotide binding]; DNA binding site 260799007166 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 260799007167 HNH endonuclease; Region: HNH_5; pfam14279 260799007168 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 260799007169 active site 260799007170 dimer interface [polypeptide binding]; other site 260799007171 non-prolyl cis peptide bond; other site 260799007172 insertion regions; other site 260799007173 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 260799007174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799007175 dimer interface [polypeptide binding]; other site 260799007176 conserved gate region; other site 260799007177 putative PBP binding loops; other site 260799007178 ABC-ATPase subunit interface; other site 260799007179 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 260799007180 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 260799007181 substrate binding pocket [chemical binding]; other site 260799007182 membrane-bound complex binding site; other site 260799007183 hinge residues; other site 260799007184 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 260799007185 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 260799007186 Walker A/P-loop; other site 260799007187 ATP binding site [chemical binding]; other site 260799007188 Q-loop/lid; other site 260799007189 ABC transporter signature motif; other site 260799007190 Walker B; other site 260799007191 D-loop; other site 260799007192 H-loop/switch region; other site 260799007193 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799007194 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799007195 Protein of unknown function (DUF402); Region: DUF402; pfam04167 260799007196 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 260799007197 nudix motif; other site 260799007198 Tetratrico peptide repeat; Region: TPR_5; pfam12688 260799007199 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799007200 binding surface 260799007201 TPR motif; other site 260799007202 hypothetical protein; Provisional; Region: PRK09620 260799007203 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 260799007204 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 260799007205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799007206 ESCO1/2 acetyl-transferase; Region: Acetyltransf_13; pfam13880 260799007207 Coenzyme A binding pocket [chemical binding]; other site 260799007208 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 260799007209 DinB superfamily; Region: DinB_2; pfam12867 260799007210 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799007211 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799007212 Coenzyme A binding pocket [chemical binding]; other site 260799007213 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799007214 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 260799007215 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 260799007216 active site 260799007217 NTP binding site [chemical binding]; other site 260799007218 metal binding triad [ion binding]; metal-binding site 260799007219 antibiotic binding site [chemical binding]; other site 260799007220 A new structural DNA glycosylase; Region: AlkD_like; cd06561 260799007221 active site 260799007222 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 260799007223 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 260799007224 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 260799007225 NodB motif; other site 260799007226 active site 260799007227 catalytic site [active] 260799007228 Zn binding site [ion binding]; other site 260799007229 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 260799007230 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 260799007231 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 260799007232 Sulfatase; Region: Sulfatase; pfam00884 260799007233 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 260799007234 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 260799007235 ABC transporter; Region: ABC_tran_2; pfam12848 260799007236 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 260799007237 hypothetical protein; Provisional; Region: PRK06761 260799007238 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799007239 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799007240 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 260799007241 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799007242 Coenzyme A binding pocket [chemical binding]; other site 260799007243 Sterol carrier protein domain; Region: SCP2_2; pfam13530 260799007244 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 260799007245 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 260799007246 hinge; other site 260799007247 active site 260799007248 prephenate dehydrogenase; Validated; Region: PRK06545 260799007249 prephenate dehydrogenase; Validated; Region: PRK08507 260799007250 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 260799007251 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 260799007252 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 260799007253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799007254 homodimer interface [polypeptide binding]; other site 260799007255 catalytic residue [active] 260799007256 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 260799007257 Tetramer interface [polypeptide binding]; other site 260799007258 active site 260799007259 FMN-binding site [chemical binding]; other site 260799007260 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 260799007261 Chorismate mutase type II; Region: CM_2; cl00693 260799007262 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 260799007263 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 260799007264 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 260799007265 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 260799007266 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 260799007267 catalytic triad [active] 260799007268 conserved cis-peptide bond; other site 260799007269 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799007270 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799007271 Coenzyme A binding pocket [chemical binding]; other site 260799007272 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 260799007273 YfzA-like protein; Region: YfzA; pfam14118 260799007274 hypothetical protein; Provisional; Region: PRK06762 260799007275 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG1102 260799007276 Bacterial SH3 domain; Region: SH3_3; pfam08239 260799007277 Bacterial SH3 domain homologues; Region: SH3b; smart00287 260799007278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 260799007279 RNA polymerase sigma factor; Provisional; Region: PRK12543 260799007280 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799007281 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 260799007282 DNA binding residues [nucleotide binding] 260799007283 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 260799007284 malate:quinone oxidoreductase; Validated; Region: PRK05257 260799007285 Predicted dehydrogenase [General function prediction only]; Region: COG0579 260799007286 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 260799007287 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 260799007288 ligand binding site [chemical binding]; other site 260799007289 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 260799007290 TM-ABC transporter signature motif; other site 260799007291 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 260799007292 TM-ABC transporter signature motif; other site 260799007293 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 260799007294 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 260799007295 Walker A/P-loop; other site 260799007296 ATP binding site [chemical binding]; other site 260799007297 Q-loop/lid; other site 260799007298 ABC transporter signature motif; other site 260799007299 Walker B; other site 260799007300 D-loop; other site 260799007301 H-loop/switch region; other site 260799007302 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 260799007303 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 260799007304 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 260799007305 Cupin domain; Region: Cupin_2; pfam07883 260799007306 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 260799007307 putative active site; other site 260799007308 catalytic residue [active] 260799007309 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799007310 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 260799007311 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 260799007312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799007313 H+ Antiporter protein; Region: 2A0121; TIGR00900 260799007314 putative substrate translocation pore; other site 260799007315 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799007316 dimerization interface [polypeptide binding]; other site 260799007317 putative DNA binding site [nucleotide binding]; other site 260799007318 putative Zn2+ binding site [ion binding]; other site 260799007319 DinB superfamily; Region: DinB_2; pfam12867 260799007320 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 260799007321 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 260799007322 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 260799007323 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 260799007324 putative catalytic cysteine [active] 260799007325 gamma-glutamyl kinase; Provisional; Region: PRK05429 260799007326 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 260799007327 nucleotide binding site [chemical binding]; other site 260799007328 homotetrameric interface [polypeptide binding]; other site 260799007329 putative phosphate binding site [ion binding]; other site 260799007330 putative allosteric binding site; other site 260799007331 PUA domain; Region: PUA; pfam01472 260799007332 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 260799007333 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 260799007334 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 260799007335 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 260799007336 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 260799007337 putative metal binding site [ion binding]; other site 260799007338 putative dimer interface [polypeptide binding]; other site 260799007339 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 260799007340 Transcriptional regulator [Transcription]; Region: IclR; COG1414 260799007341 Bacterial transcriptional regulator; Region: IclR; pfam01614 260799007342 S-methylmethionine transporter; Provisional; Region: PRK11387 260799007343 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 260799007344 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 260799007345 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 260799007346 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 260799007347 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 260799007348 putative di-iron ligands [ion binding]; other site 260799007349 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 260799007350 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 260799007351 dimer interface [polypeptide binding]; other site 260799007352 active site 260799007353 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 260799007354 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799007355 salt bridge; other site 260799007356 non-specific DNA binding site [nucleotide binding]; other site 260799007357 sequence-specific DNA binding site [nucleotide binding]; other site 260799007358 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 260799007359 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 260799007360 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 260799007361 Protein of unknown function (DUF973); Region: DUF973; pfam06157 260799007362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799007363 ATP binding site [chemical binding]; other site 260799007364 Mg2+ binding site [ion binding]; other site 260799007365 G-X-G motif; other site 260799007366 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 260799007367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 260799007368 LytTr DNA-binding domain; Region: LytTR; pfam04397 260799007369 uridine kinase; Provisional; Region: PRK07667 260799007370 active site 260799007371 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799007372 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799007373 Coenzyme A binding pocket [chemical binding]; other site 260799007374 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 260799007375 active site 260799007376 metal binding site [ion binding]; metal-binding site 260799007377 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 260799007378 Predicted transcriptional regulators [Transcription]; Region: COG1695 260799007379 MoxR-like ATPases [General function prediction only]; Region: COG0714 260799007380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799007381 Walker A motif; other site 260799007382 ATP binding site [chemical binding]; other site 260799007383 Walker B motif; other site 260799007384 arginine finger; other site 260799007385 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 260799007386 Protein of unknown function DUF58; Region: DUF58; pfam01882 260799007387 proline/glycine betaine transporter; Provisional; Region: PRK10642 260799007388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799007389 putative substrate translocation pore; other site 260799007390 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 260799007391 active site 260799007392 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 260799007393 active site 260799007394 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 260799007395 active site 260799007396 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 260799007397 Ligand binding site; other site 260799007398 Putative Catalytic site; other site 260799007399 DXD motif; other site 260799007400 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 260799007401 active site 260799007402 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 260799007403 Ligand binding site; other site 260799007404 Putative Catalytic site; other site 260799007405 DXD motif; other site 260799007406 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 260799007407 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 260799007408 inhibitor-cofactor binding pocket; inhibition site 260799007409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799007410 catalytic residue [active] 260799007411 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 260799007412 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 260799007413 tetramer interface [polypeptide binding]; other site 260799007414 heme binding pocket [chemical binding]; other site 260799007415 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 260799007416 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 260799007417 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 260799007418 active site 260799007419 Beta-lactamase; Region: Beta-lactamase; pfam00144 260799007420 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 260799007421 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 260799007422 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 260799007423 Protein of unknown function DUF58; Region: DUF58; pfam01882 260799007424 MoxR-like ATPases [General function prediction only]; Region: COG0714 260799007425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799007426 Walker A motif; other site 260799007427 ATP binding site [chemical binding]; other site 260799007428 Walker B motif; other site 260799007429 arginine finger; other site 260799007430 Uncharacterized conserved protein [Function unknown]; Region: COG1359 260799007431 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 260799007432 dimer interface [polypeptide binding]; other site 260799007433 FMN binding site [chemical binding]; other site 260799007434 Transcriptional regulators [Transcription]; Region: MarR; COG1846 260799007435 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799007436 putative DNA binding site [nucleotide binding]; other site 260799007437 putative Zn2+ binding site [ion binding]; other site 260799007438 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 260799007439 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 260799007440 G1 box; other site 260799007441 putative GEF interaction site [polypeptide binding]; other site 260799007442 GTP/Mg2+ binding site [chemical binding]; other site 260799007443 Switch I region; other site 260799007444 G2 box; other site 260799007445 G3 box; other site 260799007446 Switch II region; other site 260799007447 G4 box; other site 260799007448 G5 box; other site 260799007449 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 260799007450 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 260799007451 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 260799007452 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 260799007453 nudix motif; other site 260799007454 YfzA-like protein; Region: YfzA; pfam14118 260799007455 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 260799007456 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 260799007457 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 260799007458 Walker A/P-loop; other site 260799007459 ATP binding site [chemical binding]; other site 260799007460 Q-loop/lid; other site 260799007461 ABC transporter signature motif; other site 260799007462 Walker B; other site 260799007463 D-loop; other site 260799007464 H-loop/switch region; other site 260799007465 Predicted transcriptional regulators [Transcription]; Region: COG1725 260799007466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 260799007467 DNA-binding site [nucleotide binding]; DNA binding site 260799007468 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 260799007469 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 260799007470 putative NAD(P) binding site [chemical binding]; other site 260799007471 active site 260799007472 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 260799007473 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 260799007474 Walker A/P-loop; other site 260799007475 ATP binding site [chemical binding]; other site 260799007476 Q-loop/lid; other site 260799007477 ABC transporter signature motif; other site 260799007478 Walker B; other site 260799007479 D-loop; other site 260799007480 H-loop/switch region; other site 260799007481 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 260799007482 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 260799007483 FtsX-like permease family; Region: FtsX; pfam02687 260799007484 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 260799007485 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 260799007486 FtsX-like permease family; Region: FtsX; pfam02687 260799007487 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 260799007488 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 260799007489 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 260799007490 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 260799007491 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 260799007492 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 260799007493 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799007494 Coenzyme A binding pocket [chemical binding]; other site 260799007495 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 260799007496 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 260799007497 nudix motif; other site 260799007498 EamA-like transporter family; Region: EamA; pfam00892 260799007499 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 260799007500 EamA-like transporter family; Region: EamA; pfam00892 260799007501 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 260799007502 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 260799007503 DNA-binding site [nucleotide binding]; DNA binding site 260799007504 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 260799007505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799007506 homodimer interface [polypeptide binding]; other site 260799007507 catalytic residue [active] 260799007508 hypothetical protein; Validated; Region: PRK00124 260799007509 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 260799007510 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799007511 HAMP domain; Region: HAMP; pfam00672 260799007512 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799007513 dimer interface [polypeptide binding]; other site 260799007514 phosphorylation site [posttranslational modification] 260799007515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799007516 ATP binding site [chemical binding]; other site 260799007517 Mg2+ binding site [ion binding]; other site 260799007518 G-X-G motif; other site 260799007519 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799007520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799007521 active site 260799007522 phosphorylation site [posttranslational modification] 260799007523 intermolecular recognition site; other site 260799007524 dimerization interface [polypeptide binding]; other site 260799007525 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 260799007526 DNA binding site [nucleotide binding] 260799007527 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 260799007528 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 260799007529 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 260799007530 uridine kinase; Validated; Region: PRK06696 260799007531 active site 260799007532 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 260799007533 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 260799007534 active site 260799007535 metal binding site [ion binding]; metal-binding site 260799007536 Phosphotransferase enzyme family; Region: APH; pfam01636 260799007537 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 260799007538 active site 260799007539 substrate binding site [chemical binding]; other site 260799007540 ATP binding site [chemical binding]; other site 260799007541 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 260799007542 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 260799007543 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799007544 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799007545 Coenzyme A binding pocket [chemical binding]; other site 260799007546 lysine transporter; Provisional; Region: PRK10836 260799007547 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 260799007548 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 260799007549 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 260799007550 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 260799007551 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 260799007552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799007553 S-adenosylmethionine binding site [chemical binding]; other site 260799007554 Cephalosporin hydroxylase; Region: CmcI; pfam04989 260799007555 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 260799007556 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 260799007557 Catalytic site [active] 260799007558 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 260799007559 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 260799007560 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 260799007561 Vacuolar (H+)-ATPase G subunit; Region: V-ATPase_G; cl03922 260799007562 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 260799007563 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 260799007564 NAD+ binding site [chemical binding]; other site 260799007565 substrate binding site [chemical binding]; other site 260799007566 Zn binding site [ion binding]; other site 260799007567 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 260799007568 putative substrate binding pocket [chemical binding]; other site 260799007569 AC domain interface; other site 260799007570 catalytic triad [active] 260799007571 AB domain interface; other site 260799007572 interchain disulfide; other site 260799007573 Protein of unknown function (DUF979); Region: DUF979; pfam06166 260799007574 Protein of unknown function (DUF969); Region: DUF969; pfam06149 260799007575 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 260799007576 putative active site [active] 260799007577 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 260799007578 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 260799007579 Transcriptional regulator [Transcription]; Region: IclR; COG1414 260799007580 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 260799007581 Bacterial transcriptional regulator; Region: IclR; pfam01614 260799007582 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 260799007583 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 260799007584 Catalytic site [active] 260799007585 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 260799007586 CutC family; Region: CutC; cl01218 260799007587 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 260799007588 stage II sporulation protein P; Region: spore_II_P; TIGR02867 260799007589 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799007590 dimerization interface [polypeptide binding]; other site 260799007591 putative DNA binding site [nucleotide binding]; other site 260799007592 putative Zn2+ binding site [ion binding]; other site 260799007593 DinB superfamily; Region: DinB_2; pfam12867 260799007594 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 260799007595 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 260799007596 active site 260799007597 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 260799007598 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 260799007599 putative active site [active] 260799007600 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 260799007601 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 260799007602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 260799007603 Nucleoside recognition; Region: Gate; pfam07670 260799007604 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 260799007605 Phosphotransferase enzyme family; Region: APH; pfam01636 260799007606 putative active site [active] 260799007607 putative substrate binding site [chemical binding]; other site 260799007608 ATP binding site [chemical binding]; other site 260799007609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799007610 Coenzyme A binding pocket [chemical binding]; other site 260799007611 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 260799007612 Ferritin-like domain; Region: Ferritin; pfam00210 260799007613 dinuclear metal binding motif [ion binding]; other site 260799007614 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 260799007615 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 260799007616 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 260799007617 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799007618 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799007619 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 260799007620 phosphoenolpyruvate synthase; Validated; Region: PRK06241 260799007621 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 260799007622 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 260799007623 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 260799007624 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 260799007625 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 260799007626 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 260799007627 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 260799007628 LysE type translocator; Region: LysE; cl00565 260799007629 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 260799007630 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 260799007631 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 260799007632 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 260799007633 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 260799007634 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 260799007635 NAD binding site [chemical binding]; other site 260799007636 catalytic Zn binding site [ion binding]; other site 260799007637 structural Zn binding site [ion binding]; other site 260799007638 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 260799007639 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 260799007640 dimanganese center [ion binding]; other site 260799007641 aspartate ammonia-lyase; Provisional; Region: PRK14515 260799007642 Aspartase; Region: Aspartase; cd01357 260799007643 active sites [active] 260799007644 tetramer interface [polypeptide binding]; other site 260799007645 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 260799007646 active site 260799007647 homodimer interface [polypeptide binding]; other site 260799007648 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 260799007649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799007650 non-specific DNA binding site [nucleotide binding]; other site 260799007651 salt bridge; other site 260799007652 sequence-specific DNA binding site [nucleotide binding]; other site 260799007653 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 260799007654 GIY-YIG motif/motif A; other site 260799007655 active site 260799007656 catalytic site [active] 260799007657 putative DNA binding site [nucleotide binding]; other site 260799007658 metal binding site [ion binding]; metal-binding site 260799007659 amino acid transporter; Region: 2A0306; TIGR00909 260799007660 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 260799007661 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 260799007662 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 260799007663 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 260799007664 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 260799007665 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 260799007666 DoxX-like family; Region: DoxX_2; pfam13564 260799007667 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 260799007668 Malic enzyme, N-terminal domain; Region: malic; pfam00390 260799007669 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 260799007670 putative NAD(P) binding site [chemical binding]; other site 260799007671 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 260799007672 Spore germination protein; Region: Spore_permease; cl17796 260799007673 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 260799007674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799007675 active site 260799007676 phosphorylation site [posttranslational modification] 260799007677 intermolecular recognition site; other site 260799007678 dimerization interface [polypeptide binding]; other site 260799007679 YcbB domain; Region: YcbB; pfam08664 260799007680 glutaminase; Reviewed; Region: PRK12357 260799007681 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 260799007682 transmembrane helices; other site 260799007683 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 260799007684 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 260799007685 active site 260799007686 active site 260799007687 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 260799007688 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 260799007689 putative active site [active] 260799007690 putative metal binding site [ion binding]; other site 260799007691 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 260799007692 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 260799007693 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 260799007694 tetramer interface [polypeptide binding]; other site 260799007695 heme binding pocket [chemical binding]; other site 260799007696 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 260799007697 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799007698 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799007699 TAP-like protein; Region: Abhydrolase_4; pfam08386 260799007700 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 260799007701 catalytic triad [active] 260799007702 dimer interface [polypeptide binding]; other site 260799007703 conserved cis-peptide bond; other site 260799007704 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 260799007705 catalytic triad [active] 260799007706 dimer interface [polypeptide binding]; other site 260799007707 conserved cis-peptide bond; other site 260799007708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 260799007709 Transcriptional regulator [Transcription]; Region: LysR; COG0583 260799007710 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 260799007711 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 260799007712 dimerization interface [polypeptide binding]; other site 260799007713 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 260799007714 Cl binding site [ion binding]; other site 260799007715 oligomer interface [polypeptide binding]; other site 260799007716 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 260799007717 Mg binding site [ion binding]; other site 260799007718 nucleotide binding site [chemical binding]; other site 260799007719 putative protofilament interface [polypeptide binding]; other site 260799007720 Heat induced stress protein YflT; Region: YflT; pfam11181 260799007721 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 260799007722 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 260799007723 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 260799007724 TspO/MBR family; Region: TspO_MBR; pfam03073 260799007725 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 260799007726 DNA photolyase; Region: DNA_photolyase; pfam00875 260799007727 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 260799007728 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 260799007729 zinc binding site [ion binding]; other site 260799007730 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; cl19828 260799007731 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 260799007732 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 260799007733 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 260799007734 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 260799007735 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799007736 Coenzyme A binding pocket [chemical binding]; other site 260799007737 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 260799007738 putative active site [active] 260799007739 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 260799007740 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799007741 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 260799007742 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 260799007743 metal binding site [ion binding]; metal-binding site 260799007744 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 260799007745 ABC-ATPase subunit interface; other site 260799007746 dimer interface [polypeptide binding]; other site 260799007747 putative PBP binding regions; other site 260799007748 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 260799007749 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 260799007750 DJ-1 family protein; Region: not_thiJ; TIGR01383 260799007751 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 260799007752 conserved cys residue [active] 260799007753 Phosphotransferase enzyme family; Region: APH; pfam01636 260799007754 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 260799007755 active site 260799007756 ATP binding site [chemical binding]; other site 260799007757 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 260799007758 Low molecular weight phosphatase family; Region: LMWPc; cd00115 260799007759 active site 260799007760 arsenical-resistance protein; Region: acr3; TIGR00832 260799007761 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 260799007762 putative metal binding site [ion binding]; other site 260799007763 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799007764 dimerization interface [polypeptide binding]; other site 260799007765 putative DNA binding site [nucleotide binding]; other site 260799007766 putative Zn2+ binding site [ion binding]; other site 260799007767 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 260799007768 DnaJ domain; Region: DnaJ; pfam00226 260799007769 HSP70 interaction site [polypeptide binding]; other site 260799007770 TPR repeat; Region: TPR_11; pfam13414 260799007771 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799007772 binding surface 260799007773 TPR motif; other site 260799007774 Tetratricopeptide repeat; Region: TPR_12; pfam13424 260799007775 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 260799007776 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 260799007777 nucleotide binding site [chemical binding]; other site 260799007778 putative NEF/HSP70 interaction site [polypeptide binding]; other site 260799007779 SBD interface [polypeptide binding]; other site 260799007780 short chain dehydrogenase; Provisional; Region: PRK12746 260799007781 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 260799007782 NAD(P) binding site [chemical binding]; other site 260799007783 active site 260799007784 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 260799007785 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799007786 putative DNA binding site [nucleotide binding]; other site 260799007787 putative Zn2+ binding site [ion binding]; other site 260799007788 AsnC family; Region: AsnC_trans_reg; pfam01037 260799007789 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 260799007790 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 260799007791 metal binding site [ion binding]; metal-binding site 260799007792 AAA domain; Region: AAA_11; pfam13086 260799007793 Part of AAA domain; Region: AAA_19; pfam13245 260799007794 Erp protein C-terminus; Region: Erp_C; pfam06780 260799007795 AAA domain; Region: AAA_30; pfam13604 260799007796 AAA domain; Region: AAA_12; pfam13087 260799007797 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 260799007798 putative active site [active] 260799007799 catalytic site [active] 260799007800 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 260799007801 active site 260799007802 metal binding site [ion binding]; metal-binding site 260799007803 HEAT repeats; Region: HEAT_2; pfam13646 260799007804 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 260799007805 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 260799007806 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 260799007807 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 260799007808 putative transporter; Provisional; Region: PRK11021 260799007809 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 260799007810 Beta-lactamase; Region: Beta-lactamase; pfam00144 260799007811 putative monooxygenase; Provisional; Region: PRK11118 260799007812 DoxX-like family; Region: DoxX_2; pfam13564 260799007813 Transcriptional regulators [Transcription]; Region: MarR; COG1846 260799007814 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 260799007815 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 260799007816 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 260799007817 Flavodoxin; Region: Flavodoxin_1; pfam00258 260799007818 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 260799007819 FAD binding pocket [chemical binding]; other site 260799007820 FAD binding motif [chemical binding]; other site 260799007821 catalytic residues [active] 260799007822 NAD binding pocket [chemical binding]; other site 260799007823 phosphate binding motif [ion binding]; other site 260799007824 beta-alpha-beta structure motif; other site 260799007825 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 260799007826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799007827 putative substrate translocation pore; other site 260799007828 Malarial early transcribed membrane protein (ETRAMP); Region: ETRAMP; cl09917 260799007829 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 260799007830 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799007831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799007832 active site 260799007833 phosphorylation site [posttranslational modification] 260799007834 intermolecular recognition site; other site 260799007835 dimerization interface [polypeptide binding]; other site 260799007836 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799007837 DNA binding site [nucleotide binding] 260799007838 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799007839 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799007840 dimerization interface [polypeptide binding]; other site 260799007841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799007842 dimer interface [polypeptide binding]; other site 260799007843 phosphorylation site [posttranslational modification] 260799007844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799007845 ATP binding site [chemical binding]; other site 260799007846 Mg2+ binding site [ion binding]; other site 260799007847 G-X-G motif; other site 260799007848 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 260799007849 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 260799007850 D-cysteine desulfhydrase; Validated; Region: PRK03910 260799007851 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 260799007852 catalytic residue [active] 260799007853 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799007854 salt bridge; other site 260799007855 non-specific DNA binding site [nucleotide binding]; other site 260799007856 sequence-specific DNA binding site [nucleotide binding]; other site 260799007857 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 260799007858 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 260799007859 active site 260799007860 CoA binding site [chemical binding]; other site 260799007861 AMP binding site [chemical binding]; other site 260799007862 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 260799007863 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 260799007864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 260799007865 NAD(P) binding site [chemical binding]; other site 260799007866 active site 260799007867 hypothetical protein; Provisional; Region: PRK06849 260799007868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 260799007869 ATP-grasp domain; Region: ATP-grasp_4; cl17255 260799007870 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 260799007871 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 260799007872 dimer interface [polypeptide binding]; other site 260799007873 active site 260799007874 CoA binding pocket [chemical binding]; other site 260799007875 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 260799007876 AAA domain; Region: AAA_33; pfam13671 260799007877 AAA domain; Region: AAA_18; pfam13238 260799007878 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 260799007879 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 260799007880 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 260799007881 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 260799007882 Walker A/P-loop; other site 260799007883 ATP binding site [chemical binding]; other site 260799007884 Q-loop/lid; other site 260799007885 ABC transporter signature motif; other site 260799007886 Walker B; other site 260799007887 D-loop; other site 260799007888 H-loop/switch region; other site 260799007889 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 260799007890 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 260799007891 FtsX-like permease family; Region: FtsX; pfam02687 260799007892 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799007893 dimerization interface [polypeptide binding]; other site 260799007894 putative DNA binding site [nucleotide binding]; other site 260799007895 Predicted transcriptional regulator [Transcription]; Region: COG2345 260799007896 putative Zn2+ binding site [ion binding]; other site 260799007897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799007898 H+ Antiporter protein; Region: 2A0121; TIGR00900 260799007899 putative substrate translocation pore; other site 260799007900 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 260799007901 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799007902 dimerization interface [polypeptide binding]; other site 260799007903 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799007904 dimer interface [polypeptide binding]; other site 260799007905 phosphorylation site [posttranslational modification] 260799007906 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799007907 ATP binding site [chemical binding]; other site 260799007908 Mg2+ binding site [ion binding]; other site 260799007909 G-X-G motif; other site 260799007910 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799007911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799007912 active site 260799007913 phosphorylation site [posttranslational modification] 260799007914 intermolecular recognition site; other site 260799007915 dimerization interface [polypeptide binding]; other site 260799007916 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799007917 DNA binding site [nucleotide binding] 260799007918 Predicted membrane protein [Function unknown]; Region: COG2364 260799007919 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 260799007920 Transcriptional regulators [Transcription]; Region: MarR; COG1846 260799007921 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 260799007922 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799007923 Coenzyme A binding pocket [chemical binding]; other site 260799007924 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 260799007925 Uncharacterized conserved protein [Function unknown]; Region: COG1284 260799007926 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 260799007927 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 260799007928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799007929 D-galactonate transporter; Region: 2A0114; TIGR00893 260799007930 putative substrate translocation pore; other site 260799007931 Uncharacterized conserved protein [Function unknown]; Region: COG1556 260799007932 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 260799007933 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 260799007934 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 260799007935 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 260799007936 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 260799007937 Cysteine-rich domain; Region: CCG; pfam02754 260799007938 Cysteine-rich domain; Region: CCG; pfam02754 260799007939 Transcriptional regulator [Transcription]; Region: LysR; COG0583 260799007940 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 260799007941 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 260799007942 dimerization interface [polypeptide binding]; other site 260799007943 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 260799007944 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 260799007945 putative dimer interface [polypeptide binding]; other site 260799007946 catalytic triad [active] 260799007947 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 260799007948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 260799007949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 260799007950 active site 260799007951 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 260799007952 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 260799007953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799007954 putative substrate translocation pore; other site 260799007955 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 260799007956 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 260799007957 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 260799007958 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 260799007959 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799007960 Transcriptional regulators [Transcription]; Region: PurR; COG1609 260799007961 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 260799007962 DNA binding site [nucleotide binding] 260799007963 domain linker motif; other site 260799007964 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 260799007965 putative dimerization interface [polypeptide binding]; other site 260799007966 putative ligand binding site [chemical binding]; other site 260799007967 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799007968 TPR motif; other site 260799007969 Tetratricopeptide repeat; Region: TPR_12; pfam13424 260799007970 binding surface 260799007971 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799007972 TPR motif; other site 260799007973 binding surface 260799007974 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 260799007975 PKC phosphorylation site [posttranslational modification]; other site 260799007976 DNA polymerase IV; Reviewed; Region: PRK03103 260799007977 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 260799007978 active site 260799007979 DNA binding site [nucleotide binding] 260799007980 YolD-like protein; Region: YolD; pfam08863 260799007981 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 260799007982 Cache domain; Region: Cache_1; pfam02743 260799007983 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799007984 dimerization interface [polypeptide binding]; other site 260799007985 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 260799007986 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 260799007987 dimer interface [polypeptide binding]; other site 260799007988 putative CheW interface [polypeptide binding]; other site 260799007989 CAAX protease self-immunity; Region: Abi; pfam02517 260799007990 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799007991 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799007992 Coenzyme A binding pocket [chemical binding]; other site 260799007993 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 260799007994 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 260799007995 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 260799007996 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 260799007997 FOG: PKD repeat [General function prediction only]; Region: COG3291 260799007998 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 260799007999 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 260799008000 Fic/DOC family; Region: Fic; cl00960 260799008001 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 260799008002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799008003 putative substrate translocation pore; other site 260799008004 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799008005 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799008006 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799008007 dimerization interface [polypeptide binding]; other site 260799008008 putative DNA binding site [nucleotide binding]; other site 260799008009 putative Zn2+ binding site [ion binding]; other site 260799008010 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 260799008011 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 260799008012 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 260799008013 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 260799008014 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 260799008015 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 260799008016 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 260799008017 inhibitor-cofactor binding pocket; inhibition site 260799008018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799008019 catalytic residue [active] 260799008020 Acylphosphatase; Region: Acylphosphatase; pfam00708 260799008021 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 260799008022 HypF finger; Region: zf-HYPF; pfam07503 260799008023 HypF finger; Region: zf-HYPF; pfam07503 260799008024 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 260799008025 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 260799008026 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 260799008027 dimerization interface [polypeptide binding]; other site 260799008028 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 260799008029 ATP binding site [chemical binding]; other site 260799008030 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 260799008031 catalytic triad [active] 260799008032 conserved cis-peptide bond; other site 260799008033 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 260799008034 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799008035 putative DNA binding site [nucleotide binding]; other site 260799008036 putative Zn2+ binding site [ion binding]; other site 260799008037 AsnC family; Region: AsnC_trans_reg; pfam01037 260799008038 putative transporter; Provisional; Region: PRK11021 260799008039 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 260799008040 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 260799008041 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 260799008042 putative ligand binding site [chemical binding]; other site 260799008043 putative NAD binding site [chemical binding]; other site 260799008044 putative catalytic site [active] 260799008045 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 260799008046 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 260799008047 homodimer interface [polypeptide binding]; other site 260799008048 substrate-cofactor binding pocket; other site 260799008049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799008050 catalytic residue [active] 260799008051 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 260799008052 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 260799008053 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 260799008054 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799008055 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 260799008056 DNA binding residues [nucleotide binding] 260799008057 Domain of unknown function (DUF378); Region: DUF378; cl00943 260799008058 Cupin domain; Region: Cupin_2; cl17218 260799008059 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 260799008060 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 260799008061 Penicillin amidase; Region: Penicil_amidase; pfam01804 260799008062 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 260799008063 active site 260799008064 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 260799008065 A new structural DNA glycosylase; Region: AlkD_like; cd06561 260799008066 active site 260799008067 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 260799008068 S-layer homology domain; Region: SLH; pfam00395 260799008069 S-layer homology domain; Region: SLH; pfam00395 260799008070 S-layer homology domain; Region: SLH; pfam00395 260799008071 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 260799008072 putative metal binding site [ion binding]; other site 260799008073 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 260799008074 NETI protein; Region: NETI; pfam14044 260799008075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799008076 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799008077 putative substrate translocation pore; other site 260799008078 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 260799008079 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799008080 Transcriptional regulators [Transcription]; Region: MarR; COG1846 260799008081 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 260799008082 putative DNA binding site [nucleotide binding]; other site 260799008083 putative Zn2+ binding site [ion binding]; other site 260799008084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799008085 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799008086 putative substrate translocation pore; other site 260799008087 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 260799008088 Acyltransferase family; Region: Acyl_transf_3; cl19154 260799008089 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 260799008090 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 260799008091 Walker A/P-loop; other site 260799008092 ATP binding site [chemical binding]; other site 260799008093 Q-loop/lid; other site 260799008094 ABC transporter signature motif; other site 260799008095 Walker B; other site 260799008096 D-loop; other site 260799008097 H-loop/switch region; other site 260799008098 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 260799008099 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799008100 putative DNA binding site [nucleotide binding]; other site 260799008101 putative Zn2+ binding site [ion binding]; other site 260799008102 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 260799008103 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799008104 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799008105 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 260799008106 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 260799008107 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 260799008108 SWIM zinc finger; Region: SWIM; pfam04434 260799008109 YwiC-like protein; Region: YwiC; pfam14256 260799008110 Protein of unknown function (DUF3816); Region: DUF3816; cl17272 260799008111 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 260799008112 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 260799008113 Walker A/P-loop; other site 260799008114 ATP binding site [chemical binding]; other site 260799008115 Q-loop/lid; other site 260799008116 ABC transporter signature motif; other site 260799008117 Walker B; other site 260799008118 D-loop; other site 260799008119 H-loop/switch region; other site 260799008120 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 260799008121 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 260799008122 Walker A/P-loop; other site 260799008123 ATP binding site [chemical binding]; other site 260799008124 Q-loop/lid; other site 260799008125 ABC transporter signature motif; other site 260799008126 Walker B; other site 260799008127 D-loop; other site 260799008128 H-loop/switch region; other site 260799008129 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 260799008130 Domain of unknown function (DUF4430); Region: DUF4430; pfam14478 260799008131 Domain of unknown function (DUF4430); Region: DUF4430; pfam14478 260799008132 Procyclic acidic repetitive protein (PARP); Region: Trypan_PARP; pfam05887 260799008133 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 260799008134 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 260799008135 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 260799008136 Predicted membrane protein [Function unknown]; Region: COG1288 260799008137 Endonuclease I; Region: Endonuclease_1; pfam04231 260799008138 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799008139 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 260799008140 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 260799008141 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799008142 non-specific DNA binding site [nucleotide binding]; other site 260799008143 salt bridge; other site 260799008144 sequence-specific DNA binding site [nucleotide binding]; other site 260799008145 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 260799008146 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 260799008147 putative deacylase active site [active] 260799008148 histidyl-tRNA synthetase; Provisional; Region: PRK12420 260799008149 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 260799008150 dimer interface [polypeptide binding]; other site 260799008151 motif 1; other site 260799008152 active site 260799008153 motif 2; other site 260799008154 motif 3; other site 260799008155 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 260799008156 anticodon binding site; other site 260799008157 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 260799008158 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 260799008159 dimer interface [polypeptide binding]; other site 260799008160 FMN binding site [chemical binding]; other site 260799008161 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 260799008162 pyruvate kinase; Validated; Region: PRK06739 260799008163 protein kinase; Provisional; Region: PTZ00284 260799008164 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 260799008165 classical (c) SDRs; Region: SDR_c; cd05233 260799008166 NAD(P) binding site [chemical binding]; other site 260799008167 active site 260799008168 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 260799008169 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 260799008170 Walker A/P-loop; other site 260799008171 ATP binding site [chemical binding]; other site 260799008172 Q-loop/lid; other site 260799008173 ABC transporter signature motif; other site 260799008174 Walker B; other site 260799008175 D-loop; other site 260799008176 H-loop/switch region; other site 260799008177 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 260799008178 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799008179 non-specific DNA binding site [nucleotide binding]; other site 260799008180 salt bridge; other site 260799008181 sequence-specific DNA binding site [nucleotide binding]; other site 260799008182 HAD-hyrolase-like; Region: Hydrolase_like; cl19142 260799008183 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 260799008184 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799008185 motif II; other site 260799008186 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 260799008187 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 260799008188 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 260799008189 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 260799008190 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799008191 Coenzyme A binding pocket [chemical binding]; other site 260799008192 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 260799008193 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 260799008194 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 260799008195 putative metal binding site [ion binding]; other site 260799008196 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 260799008197 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 260799008198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799008199 putative substrate translocation pore; other site 260799008200 D-galactonate transporter; Region: 2A0114; TIGR00893 260799008201 maltose O-acetyltransferase; Provisional; Region: PRK10092 260799008202 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 260799008203 active site 260799008204 substrate binding site [chemical binding]; other site 260799008205 trimer interface [polypeptide binding]; other site 260799008206 CoA binding site [chemical binding]; other site 260799008207 FtsX-like permease family; Region: FtsX; pfam02687 260799008208 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 260799008209 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 260799008210 FtsX-like permease family; Region: FtsX; pfam02687 260799008211 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 260799008212 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 260799008213 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 260799008214 Walker A/P-loop; other site 260799008215 ATP binding site [chemical binding]; other site 260799008216 Q-loop/lid; other site 260799008217 ABC transporter signature motif; other site 260799008218 Walker B; other site 260799008219 D-loop; other site 260799008220 H-loop/switch region; other site 260799008221 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 260799008222 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 260799008223 active site 260799008224 HIGH motif; other site 260799008225 dimer interface [polypeptide binding]; other site 260799008226 KMSKS motif; other site 260799008227 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 260799008228 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 260799008229 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 260799008230 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 260799008231 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 260799008232 Predicted membrane protein [Function unknown]; Region: COG2261 260799008233 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799008234 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 260799008235 Coenzyme A binding pocket [chemical binding]; other site 260799008236 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 260799008237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799008238 S-adenosylmethionine binding site [chemical binding]; other site 260799008239 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 260799008240 CGNR zinc finger; Region: zf-CGNR; pfam11706 260799008241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799008242 multidrug resistance protein MdtH; Provisional; Region: PRK11646 260799008243 putative substrate translocation pore; other site 260799008244 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799008245 TPR motif; other site 260799008246 TPR repeat; Region: TPR_11; pfam13414 260799008247 binding surface 260799008248 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799008249 binding surface 260799008250 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 260799008251 TPR motif; other site 260799008252 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 260799008253 hypothetical protein; Provisional; Region: PRK04164 260799008254 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl19873 260799008255 ATP synthase I chain; Region: ATP_synt_I; pfam03899 260799008256 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 260799008257 Domain of unknown function DUF21; Region: DUF21; pfam01595 260799008258 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 260799008259 Transporter associated domain; Region: CorC_HlyC; smart01091 260799008260 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 260799008261 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 260799008262 DNA binding residues [nucleotide binding] 260799008263 putative dimer interface [polypeptide binding]; other site 260799008264 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 260799008265 EamA-like transporter family; Region: EamA; pfam00892 260799008266 EamA-like transporter family; Region: EamA; pfam00892 260799008267 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 260799008268 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 260799008269 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 260799008270 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 260799008271 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 260799008272 N- and C-terminal domain interface [polypeptide binding]; other site 260799008273 active site 260799008274 catalytic site [active] 260799008275 metal binding site [ion binding]; metal-binding site 260799008276 carbohydrate binding site [chemical binding]; other site 260799008277 ATP binding site [chemical binding]; other site 260799008278 GntP family permease; Region: GntP_permease; pfam02447 260799008279 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 260799008280 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 260799008281 active site 260799008282 intersubunit interactions; other site 260799008283 catalytic residue [active] 260799008284 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 260799008285 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 260799008286 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 260799008287 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 260799008288 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 260799008289 TPP-binding site [chemical binding]; other site 260799008290 dimer interface [polypeptide binding]; other site 260799008291 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 260799008292 PYR/PP interface [polypeptide binding]; other site 260799008293 dimer interface [polypeptide binding]; other site 260799008294 TPP binding site [chemical binding]; other site 260799008295 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 260799008296 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 260799008297 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 260799008298 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 260799008299 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 260799008300 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 260799008301 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 260799008302 putative NAD(P) binding site [chemical binding]; other site 260799008303 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 260799008304 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 260799008305 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 260799008306 putative NAD(P) binding site [chemical binding]; other site 260799008307 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 260799008308 classical (c) SDRs; Region: SDR_c; cd05233 260799008309 NAD(P) binding site [chemical binding]; other site 260799008310 active site 260799008311 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 260799008312 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 260799008313 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 260799008314 active site 260799008315 Zn binding site [ion binding]; other site 260799008316 Peptidase M60-like family; Region: M60-like; cl19940 260799008317 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 260799008318 dimer interface [polypeptide binding]; other site 260799008319 FMN binding site [chemical binding]; other site 260799008320 BNR repeat-like domain; Region: BNR_2; pfam13088 260799008321 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 260799008322 active site 260799008323 catalytic tetrad [active] 260799008324 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 260799008325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799008326 putative substrate translocation pore; other site 260799008327 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 260799008328 active site 1 [active] 260799008329 dimer interface [polypeptide binding]; other site 260799008330 hexamer interface [polypeptide binding]; other site 260799008331 active site 2 [active] 260799008332 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 260799008333 hexamer interface [polypeptide binding]; other site 260799008334 active site 2 [active] 260799008335 hypothetical protein; Provisional; Region: PRK02487 260799008336 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 260799008337 active site 260799008338 metal binding site [ion binding]; metal-binding site 260799008339 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 260799008340 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 260799008341 IDEAL domain; Region: IDEAL; pfam08858 260799008342 Predicted transcriptional regulator [Transcription]; Region: COG1959 260799008343 Rrf2 family protein; Region: rrf2_super; TIGR00738 260799008344 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 260799008345 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 260799008346 putative catalytic residues [active] 260799008347 thiol/disulfide switch; other site 260799008348 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799008349 dimerization interface [polypeptide binding]; other site 260799008350 putative DNA binding site [nucleotide binding]; other site 260799008351 putative Zn2+ binding site [ion binding]; other site 260799008352 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 260799008353 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 260799008354 DNA-binding site [nucleotide binding]; DNA binding site 260799008355 UTRA domain; Region: UTRA; pfam07702 260799008356 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 260799008357 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799008358 S-adenosylmethionine binding site [chemical binding]; other site 260799008359 Predicted transcriptional regulators [Transcription]; Region: COG1733 260799008360 dimerization interface [polypeptide binding]; other site 260799008361 putative DNA binding site [nucleotide binding]; other site 260799008362 putative Zn2+ binding site [ion binding]; other site 260799008363 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799008364 dimerization interface [polypeptide binding]; other site 260799008365 putative DNA binding site [nucleotide binding]; other site 260799008366 putative Zn2+ binding site [ion binding]; other site 260799008367 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 260799008368 active site 260799008369 catalytic tetrad [active] 260799008370 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 260799008371 putative hydrophobic ligand binding site [chemical binding]; other site 260799008372 protein interface [polypeptide binding]; other site 260799008373 gate; other site 260799008374 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 260799008375 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 260799008376 active site 260799008377 substrate binding site [chemical binding]; other site 260799008378 ATP binding site [chemical binding]; other site 260799008379 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 260799008380 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 260799008381 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 260799008382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799008383 Coenzyme A binding pocket [chemical binding]; other site 260799008384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 260799008385 short chain dehydrogenase; Region: adh_short; pfam00106 260799008386 NAD(P) binding site [chemical binding]; other site 260799008387 active site 260799008388 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 260799008389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 260799008390 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 260799008391 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 260799008392 acyl-activating enzyme (AAE) consensus motif; other site 260799008393 AMP binding site [chemical binding]; other site 260799008394 active site 260799008395 CoA binding site [chemical binding]; other site 260799008396 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799008397 dimerization interface [polypeptide binding]; other site 260799008398 putative DNA binding site [nucleotide binding]; other site 260799008399 putative Zn2+ binding site [ion binding]; other site 260799008400 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 260799008401 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 260799008402 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 260799008403 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 260799008404 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 260799008405 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799008406 dimerization interface [polypeptide binding]; other site 260799008407 putative DNA binding site [nucleotide binding]; other site 260799008408 putative Zn2+ binding site [ion binding]; other site 260799008409 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 260799008410 RNA polymerase sigma-I factor; Region: spore_sigI; TIGR02895 260799008411 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799008412 CAAX protease self-immunity; Region: Abi; pfam02517 260799008413 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799008414 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799008415 Protein of unknown function (DUF3963); Region: DUF3963; pfam13124 260799008416 Integron-associated effector binding protein; Region: Cass2; pfam14526 260799008417 Protein of unknown function (DUF805); Region: DUF805; pfam05656 260799008418 ABC-2 type transporter; Region: ABC2_membrane; cl17235 260799008419 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 260799008420 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 260799008421 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 260799008422 Walker A/P-loop; other site 260799008423 ATP binding site [chemical binding]; other site 260799008424 Q-loop/lid; other site 260799008425 ABC transporter signature motif; other site 260799008426 Walker B; other site 260799008427 D-loop; other site 260799008428 H-loop/switch region; other site 260799008429 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 260799008430 Predicted transcriptional regulators [Transcription]; Region: COG1695 260799008431 hydroxylamine reductase; Provisional; Region: PRK12310 260799008432 ACS interaction site; other site 260799008433 CODH interaction site; other site 260799008434 metal cluster binding site [ion binding]; other site 260799008435 Protein of unknown function (DUF1625); Region: DUF1625; pfam07787 260799008436 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 260799008437 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 260799008438 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 260799008439 active site 260799008440 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 260799008441 metal binding site [ion binding]; metal-binding site 260799008442 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 260799008443 hypothetical protein; Provisional; Region: PRK06771 260799008444 Beta-lactamase; Region: Beta-lactamase; pfam00144 260799008445 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 260799008446 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 260799008447 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 260799008448 dimer interface [polypeptide binding]; other site 260799008449 ligand binding site [chemical binding]; other site 260799008450 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 260799008451 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 260799008452 ligand binding site [chemical binding]; other site 260799008453 flexible hinge region; other site 260799008454 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 260799008455 Protein of unknown function, DUF606; Region: DUF606; pfam04657 260799008456 Protein of unknown function, DUF606; Region: DUF606; pfam04657 260799008457 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 260799008458 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 260799008459 putative NAD(P) binding site [chemical binding]; other site 260799008460 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 260799008461 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 260799008462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799008463 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 260799008464 putative substrate translocation pore; other site 260799008465 Haemolysin XhlA; Region: XhlA; pfam10779 260799008466 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 260799008467 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 260799008468 Citrate transporter; Region: CitMHS; pfam03600 260799008469 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 260799008470 transmembrane helices; other site 260799008471 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 260799008472 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 260799008473 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799008474 Coenzyme A binding pocket [chemical binding]; other site 260799008475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 260799008476 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 260799008477 putative ligand binding residues [chemical binding]; other site 260799008478 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 260799008479 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 260799008480 ABC-ATPase subunit interface; other site 260799008481 dimer interface [polypeptide binding]; other site 260799008482 putative PBP binding regions; other site 260799008483 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 260799008484 ABC-ATPase subunit interface; other site 260799008485 dimer interface [polypeptide binding]; other site 260799008486 putative PBP binding regions; other site 260799008487 Protein of unknown function (DUF817); Region: DUF817; pfam05675 260799008488 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 260799008489 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 260799008490 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 260799008491 DinB superfamily; Region: DinB_2; pfam12867 260799008492 DinB family; Region: DinB; cl17821 260799008493 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 260799008494 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 260799008495 Transcriptional regulator [Transcription]; Region: LysR; COG0583 260799008496 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 260799008497 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 260799008498 dimerization interface [polypeptide binding]; other site 260799008499 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 260799008500 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 260799008501 NADP binding site [chemical binding]; other site 260799008502 dimer interface [polypeptide binding]; other site 260799008503 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 260799008504 catalytic core [active] 260799008505 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799008506 Coenzyme A binding pocket [chemical binding]; other site 260799008507 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 260799008508 MutS domain III; Region: MutS_III; pfam05192 260799008509 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 260799008510 Walker A/P-loop; other site 260799008511 ATP binding site [chemical binding]; other site 260799008512 Q-loop/lid; other site 260799008513 ABC transporter signature motif; other site 260799008514 Walker B; other site 260799008515 D-loop; other site 260799008516 H-loop/switch region; other site 260799008517 exosporium leader peptide; Region: exospor_lead; TIGR03720 260799008518 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 260799008519 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 260799008520 active site 260799008521 Na/Ca binding site [ion binding]; other site 260799008522 catalytic site [active] 260799008523 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 260799008524 oligoendopeptidase F; Region: pepF; TIGR00181 260799008525 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 260799008526 active site 260799008527 Zn binding site [ion binding]; other site 260799008528 Beta-lactamase; Region: Beta-lactamase; pfam00144 260799008529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799008530 putative substrate translocation pore; other site 260799008531 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799008532 Transcriptional regulator [Transcription]; Region: LysR; COG0583 260799008533 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 260799008534 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 260799008535 putative dimerization interface [polypeptide binding]; other site 260799008536 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 260799008537 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 260799008538 putative active site [active] 260799008539 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 260799008540 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 260799008541 active site 260799008542 catalytic site [active] 260799008543 metal binding site [ion binding]; metal-binding site 260799008544 hypothetical protein; Provisional; Region: PRK06126 260799008545 FAD binding domain; Region: FAD_binding_3; pfam01494 260799008546 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799008547 dimerization interface [polypeptide binding]; other site 260799008548 putative DNA binding site [nucleotide binding]; other site 260799008549 putative Zn2+ binding site [ion binding]; other site 260799008550 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 260799008551 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 260799008552 putative NAD(P) binding site [chemical binding]; other site 260799008553 hypothetical protein; Validated; Region: PRK00029 260799008554 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 260799008555 GrpB protein; Region: GrpB; pfam04229 260799008556 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 260799008557 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 260799008558 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 260799008559 FAD binding domain; Region: FAD_binding_4; pfam01565 260799008560 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 260799008561 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 260799008562 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 260799008563 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 260799008564 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 260799008565 trimer interface [polypeptide binding]; other site 260799008566 active site 260799008567 substrate binding site [chemical binding]; other site 260799008568 CoA binding site [chemical binding]; other site 260799008569 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 260799008570 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 260799008571 catalytic residue [active] 260799008572 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 260799008573 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 260799008574 active site 260799008575 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 260799008576 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 260799008577 active site 260799008578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799008579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 260799008580 enoyl-CoA hydratase; Provisional; Region: PRK06688 260799008581 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 260799008582 substrate binding site [chemical binding]; other site 260799008583 oxyanion hole (OAH) forming residues; other site 260799008584 trimer interface [polypeptide binding]; other site 260799008585 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 260799008586 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 260799008587 FOG: PKD repeat [General function prediction only]; Region: COG3291 260799008588 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 260799008589 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 260799008590 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 260799008591 MgtC family; Region: MgtC; pfam02308 260799008592 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799008593 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799008594 Coenzyme A binding pocket [chemical binding]; other site 260799008595 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 260799008596 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 260799008597 putative metal binding site [ion binding]; other site 260799008598 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 260799008599 active site 260799008600 metal binding site [ion binding]; metal-binding site 260799008601 VanW like protein; Region: VanW; pfam04294 260799008602 Haemolysin XhlA; Region: XhlA; pfam10779 260799008603 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 260799008604 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 260799008605 exonuclease; Provisional; Region: PRK06722 260799008606 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 260799008607 active site 260799008608 catalytic site [active] 260799008609 substrate binding site [chemical binding]; other site 260799008610 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 260799008611 DNA-binding site [nucleotide binding]; DNA binding site 260799008612 RNA-binding motif; other site 260799008613 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 260799008614 flavodoxin; Provisional; Region: PRK06703 260799008615 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 260799008616 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_11; cd04669 260799008617 nudix motif; other site 260799008618 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 260799008619 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 260799008620 trimer interface [polypeptide binding]; other site 260799008621 active site 260799008622 substrate binding site [chemical binding]; other site 260799008623 CoA binding site [chemical binding]; other site 260799008624 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008625 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008626 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008627 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008628 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008629 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008630 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008631 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008632 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008633 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008634 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008635 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008636 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008637 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008638 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008639 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 260799008640 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 260799008641 NADP binding site [chemical binding]; other site 260799008642 homodimer interface [polypeptide binding]; other site 260799008643 active site 260799008644 Predicted acetyltransferase [General function prediction only]; Region: COG3393 260799008645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 260799008646 argininosuccinate lyase; Provisional; Region: PRK06705 260799008647 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 260799008648 active sites [active] 260799008649 tetramer interface [polypeptide binding]; other site 260799008650 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 260799008651 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 260799008652 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235 260799008653 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 260799008654 active site 260799008655 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 260799008656 Na binding site [ion binding]; other site 260799008657 Protein of unknown function (DUF997); Region: DUF997; pfam06196 260799008658 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 260799008659 NAD(P) binding site [chemical binding]; other site 260799008660 catalytic residues [active] 260799008661 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 260799008662 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 260799008663 NAD(P) binding site [chemical binding]; other site 260799008664 homotetramer interface [polypeptide binding]; other site 260799008665 homodimer interface [polypeptide binding]; other site 260799008666 active site 260799008667 YfhD-like protein; Region: YfhD; pfam14151 260799008668 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 260799008669 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 260799008670 Divergent PAP2 family; Region: DUF212; pfam02681 260799008671 Predicted permeases [General function prediction only]; Region: RarD; COG2962 260799008672 EamA-like transporter family; Region: EamA; pfam00892 260799008673 EamA-like transporter family; Region: EamA; pfam00892 260799008674 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 260799008675 antiporter inner membrane protein; Provisional; Region: PRK11670 260799008676 Domain of unknown function DUF59; Region: DUF59; pfam01883 260799008677 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 260799008678 Walker A motif; other site 260799008679 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 260799008680 MoaE interaction surface [polypeptide binding]; other site 260799008681 MoeB interaction surface [polypeptide binding]; other site 260799008682 thiocarboxylated glycine; other site 260799008683 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 260799008684 MoaE homodimer interface [polypeptide binding]; other site 260799008685 MoaD interaction [polypeptide binding]; other site 260799008686 active site residues [active] 260799008687 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 260799008688 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 260799008689 dimer interface [polypeptide binding]; other site 260799008690 putative functional site; other site 260799008691 putative MPT binding site; other site 260799008692 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 260799008693 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 260799008694 ATP binding site [chemical binding]; other site 260799008695 substrate interface [chemical binding]; other site 260799008696 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 260799008697 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 260799008698 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 260799008699 FeS/SAM binding site; other site 260799008700 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 260799008701 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 260799008702 Uncharacterized conserved protein [Function unknown]; Region: COG5609 260799008703 Uncharacterized conserved protein [Function unknown]; Region: COG2427 260799008704 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 260799008705 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 260799008706 catalytic loop [active] 260799008707 iron binding site [ion binding]; other site 260799008708 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 260799008709 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 260799008710 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 260799008711 [4Fe-4S] binding site [ion binding]; other site 260799008712 molybdopterin cofactor binding site; other site 260799008713 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 260799008714 molybdopterin cofactor binding site; other site 260799008715 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 260799008716 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 260799008717 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl19906 260799008718 Tubulin like; Region: Tubulin_2; pfam13809 260799008719 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 260799008720 metal ion-dependent adhesion site (MIDAS); other site 260799008721 Methyltransferase domain; Region: Methyltransf_31; pfam13847 260799008722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799008723 S-adenosylmethionine binding site [chemical binding]; other site 260799008724 O-methyltransferase; Region: Methyltransf_2; pfam00891 260799008725 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 260799008726 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 260799008727 peptide binding site [polypeptide binding]; other site 260799008728 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 260799008729 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 260799008730 peptide binding site [polypeptide binding]; other site 260799008731 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 260799008732 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 260799008733 peptide binding site [polypeptide binding]; other site 260799008734 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 260799008735 Transcriptional regulator [Transcription]; Region: LytR; COG1316 260799008736 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 260799008737 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799008738 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 260799008739 DNA binding residues [nucleotide binding] 260799008740 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 260799008741 Acyltransferase family; Region: Acyl_transf_3; cl19154 260799008742 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 260799008743 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 260799008744 Walker A/P-loop; other site 260799008745 ATP binding site [chemical binding]; other site 260799008746 Q-loop/lid; other site 260799008747 ABC transporter signature motif; other site 260799008748 Walker B; other site 260799008749 D-loop; other site 260799008750 H-loop/switch region; other site 260799008751 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799008752 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799008753 putative oxidoreductase; Provisional; Region: PRK11579 260799008754 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 260799008755 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 260799008756 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 260799008757 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 260799008758 CAP-like domain; other site 260799008759 active site 260799008760 primary dimer interface [polypeptide binding]; other site 260799008761 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 260799008762 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 260799008763 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 260799008764 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 260799008765 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 260799008766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799008767 ATP binding site [chemical binding]; other site 260799008768 Mg2+ binding site [ion binding]; other site 260799008769 G-X-G motif; other site 260799008770 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 260799008771 anchoring element; other site 260799008772 dimer interface [polypeptide binding]; other site 260799008773 ATP binding site [chemical binding]; other site 260799008774 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 260799008775 active site 260799008776 metal binding site [ion binding]; metal-binding site 260799008777 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 260799008778 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 260799008779 Trypsin; Region: Trypsin; pfam00089 260799008780 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 260799008781 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 260799008782 protein binding site [polypeptide binding]; other site 260799008783 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799008784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799008785 active site 260799008786 phosphorylation site [posttranslational modification] 260799008787 intermolecular recognition site; other site 260799008788 dimerization interface [polypeptide binding]; other site 260799008789 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799008790 DNA binding site [nucleotide binding] 260799008791 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 260799008792 Class III ribonucleotide reductase; Region: RNR_III; cd01675 260799008793 effector binding site; other site 260799008794 active site 260799008795 Zn binding site [ion binding]; other site 260799008796 glycine loop; other site 260799008797 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 260799008798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 260799008799 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 260799008800 active site 260799008801 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 260799008802 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 260799008803 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 260799008804 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 260799008805 active site 260799008806 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 260799008807 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 260799008808 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 260799008809 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 260799008810 active site 260799008811 catalytic site [active] 260799008812 substrate binding site [chemical binding]; other site 260799008813 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 260799008814 catalytic residues [active] 260799008815 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 260799008816 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 260799008817 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 260799008818 Walker A/P-loop; other site 260799008819 ATP binding site [chemical binding]; other site 260799008820 ABC transporter signature motif; other site 260799008821 Walker B; other site 260799008822 D-loop; other site 260799008823 H-loop/switch region; other site 260799008824 aconitate hydratase; Validated; Region: PRK09277 260799008825 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 260799008826 substrate binding site [chemical binding]; other site 260799008827 ligand binding site [chemical binding]; other site 260799008828 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 260799008829 substrate binding site [chemical binding]; other site 260799008830 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 260799008831 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 260799008832 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 260799008833 NodB motif; other site 260799008834 active site 260799008835 catalytic site [active] 260799008836 metal binding site [ion binding]; metal-binding site 260799008837 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 260799008838 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 260799008839 putative dimer interface [polypeptide binding]; other site 260799008840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799008841 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 260799008842 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 260799008843 DHHA1 domain; Region: DHHA1; pfam02272 260799008844 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 260799008845 nudix motif; other site 260799008846 SAP domain; Region: SAP; pfam02037 260799008847 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 260799008848 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 260799008849 dimer interface [polypeptide binding]; other site 260799008850 active site 260799008851 acyl-CoA synthetase; Validated; Region: PRK07638 260799008852 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 260799008853 acyl-activating enzyme (AAE) consensus motif; other site 260799008854 AMP binding site [chemical binding]; other site 260799008855 active site 260799008856 CoA binding site [chemical binding]; other site 260799008857 BioY family; Region: BioY; pfam02632 260799008858 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 260799008859 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 260799008860 dimer interface [polypeptide binding]; other site 260799008861 acyl-activating enzyme (AAE) consensus motif; other site 260799008862 putative active site [active] 260799008863 AMP binding site [chemical binding]; other site 260799008864 putative CoA binding site [chemical binding]; other site 260799008865 GCN5-related N-acetyltransferases (GNAT) represent a large superfamily of functionally diverse enzymes that catalyze the transfer of an acetyl group from acetyl-Coenzyme A to the primary amine of a wide range of acceptor substrates. Members of this...; Region: GNAT; cl00443 260799008866 Coenzyme A binding pocket; other site 260799008867 CsbD-like; Region: CsbD; pfam05532 260799008868 S-layer homology domain; Region: SLH; pfam00395 260799008869 S-layer homology domain; Region: SLH; pfam00395 260799008870 S-layer homology domain; Region: SLH; pfam00395 260799008871 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 260799008872 active site 260799008873 catalytic motif [active] 260799008874 Zn binding site [ion binding]; other site 260799008875 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 260799008876 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 260799008877 amidase catalytic site [active] 260799008878 Zn binding residues [ion binding]; other site 260799008879 substrate binding site [chemical binding]; other site 260799008880 active site 260799008881 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 260799008882 Uncharacterized conserved protein [Function unknown]; Region: COG1284 260799008883 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 260799008884 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 260799008885 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 260799008886 dimer interface [polypeptide binding]; other site 260799008887 putative metal binding site [ion binding]; other site 260799008888 PAS domain S-box; Region: sensory_box; TIGR00229 260799008889 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 260799008890 putative active site [active] 260799008891 heme pocket [chemical binding]; other site 260799008892 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 260799008893 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 260799008894 putative active site [active] 260799008895 heme pocket [chemical binding]; other site 260799008896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799008897 dimer interface [polypeptide binding]; other site 260799008898 phosphorylation site [posttranslational modification] 260799008899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799008900 ATP binding site [chemical binding]; other site 260799008901 Mg2+ binding site [ion binding]; other site 260799008902 G-X-G motif; other site 260799008903 Predicted esterase [General function prediction only]; Region: COG0400 260799008904 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 260799008905 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 260799008906 Zn binding site [ion binding]; other site 260799008907 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 260799008908 Zn binding site [ion binding]; other site 260799008909 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 260799008910 Na binding site [ion binding]; other site 260799008911 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 260799008912 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 260799008913 active site 260799008914 FMN binding site [chemical binding]; other site 260799008915 substrate binding site [chemical binding]; other site 260799008916 3Fe-4S cluster binding site [ion binding]; other site 260799008917 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 260799008918 FMN binding site [chemical binding]; other site 260799008919 active site 260799008920 substrate binding site [chemical binding]; other site 260799008921 catalytic residue [active] 260799008922 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 260799008923 Agmatinase-like family; Region: Agmatinase-like; cd09990 260799008924 active site 260799008925 oligomer interface [polypeptide binding]; other site 260799008926 Mn binding site [ion binding]; other site 260799008927 imidazolonepropionase; Validated; Region: PRK09356 260799008928 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 260799008929 active site 260799008930 urocanate hydratase; Provisional; Region: PRK05414 260799008931 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 260799008932 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 260799008933 active sites [active] 260799008934 tetramer interface [polypeptide binding]; other site 260799008935 anti-terminator HutP; Provisional; Region: hutP; PRK03065 260799008936 hexamer interface [polypeptide binding]; other site 260799008937 RNA binding site [nucleotide binding]; other site 260799008938 Histidine-zinc binding site [chemical binding]; other site 260799008939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799008940 S-adenosylmethionine binding site [chemical binding]; other site 260799008941 DJ-1 family protein; Region: not_thiJ; TIGR01383 260799008942 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 260799008943 conserved cys residue [active] 260799008944 AAA domain; Region: AAA_28; pfam13521 260799008945 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 260799008946 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008947 Domain of unknown function DUF11; Region: DUF11; cl17728 260799008948 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008949 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008950 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008951 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008952 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008953 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008954 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 260799008955 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008956 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008957 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008958 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008959 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008960 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008961 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008962 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008963 conserved repeat domain; Region: B_ant_repeat; TIGR01451 260799008964 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 260799008965 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 260799008966 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 260799008967 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 260799008968 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 260799008969 putative dimerization interface [polypeptide binding]; other site 260799008970 putative substrate binding pocket [chemical binding]; other site 260799008971 holin-like protein; Validated; Region: PRK01658 260799008972 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 260799008973 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 260799008974 nudix motif; other site 260799008975 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 260799008976 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 260799008977 amidase catalytic site [active] 260799008978 Zn binding residues [ion binding]; other site 260799008979 substrate binding site [chemical binding]; other site 260799008980 S-layer homology domain; Region: SLH; pfam00395 260799008981 S-layer homology domain; Region: SLH; pfam00395 260799008982 S-layer homology domain; Region: SLH; pfam00395 260799008983 Nuclease-related domain; Region: NERD; pfam08378 260799008984 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 260799008985 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 260799008986 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 260799008987 Walker A/P-loop; other site 260799008988 ATP binding site [chemical binding]; other site 260799008989 Q-loop/lid; other site 260799008990 ABC transporter signature motif; other site 260799008991 Walker B; other site 260799008992 D-loop; other site 260799008993 H-loop/switch region; other site 260799008994 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 260799008995 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 260799008996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 260799008997 Walker A/P-loop; other site 260799008998 ATP binding site [chemical binding]; other site 260799008999 Q-loop/lid; other site 260799009000 ABC transporter signature motif; other site 260799009001 Walker B; other site 260799009002 D-loop; other site 260799009003 H-loop/switch region; other site 260799009004 hypothetical protein; Provisional; Region: PRK01844 260799009005 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 260799009006 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 260799009007 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 260799009008 TPP-binding site [chemical binding]; other site 260799009009 dimer interface [polypeptide binding]; other site 260799009010 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 260799009011 PYR/PP interface [polypeptide binding]; other site 260799009012 dimer interface [polypeptide binding]; other site 260799009013 TPP binding site [chemical binding]; other site 260799009014 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 260799009015 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 260799009016 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 260799009017 Probable transposase; Region: OrfB_IS605; pfam01385 260799009018 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 260799009019 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 260799009020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799009021 dimer interface [polypeptide binding]; other site 260799009022 conserved gate region; other site 260799009023 putative PBP binding loops; other site 260799009024 ABC-ATPase subunit interface; other site 260799009025 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 260799009026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799009027 dimer interface [polypeptide binding]; other site 260799009028 conserved gate region; other site 260799009029 putative PBP binding loops; other site 260799009030 ABC-ATPase subunit interface; other site 260799009031 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 260799009032 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 260799009033 Walker A/P-loop; other site 260799009034 ATP binding site [chemical binding]; other site 260799009035 Q-loop/lid; other site 260799009036 ABC transporter signature motif; other site 260799009037 Walker B; other site 260799009038 D-loop; other site 260799009039 H-loop/switch region; other site 260799009040 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 260799009041 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 260799009042 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 260799009043 membrane-bound complex binding site; other site 260799009044 hypothetical protein; Provisional; Region: PRK01546 260799009045 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 260799009046 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 260799009047 catalytic residues [active] 260799009048 catalytic nucleophile [active] 260799009049 LexA repressor; Validated; Region: PRK00215 260799009050 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799009051 putative DNA binding site [nucleotide binding]; other site 260799009052 putative Zn2+ binding site [ion binding]; other site 260799009053 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 260799009054 Catalytic site [active] 260799009055 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 260799009056 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 260799009057 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 260799009058 Predicted transcriptional regulators [Transcription]; Region: COG1695 260799009059 Tetratricopeptide repeat; Region: TPR_12; pfam13424 260799009060 Helix-turn-helix domain; Region: HTH_17; pfam12728 260799009061 Helix-turn-helix domain; Region: HTH_17; pfam12728 260799009062 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 260799009063 amidase catalytic site [active] 260799009064 Zn binding residues [ion binding]; other site 260799009065 substrate binding site [chemical binding]; other site 260799009066 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 260799009067 Bacterial SH3 domain; Region: SH3_3; pfam08239 260799009068 Holin family; Region: Phage_holin_4; pfam05105 260799009069 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 260799009070 Phage-related minor tail protein [Function unknown]; Region: COG5280 260799009071 membrane protein P6; Region: PHA01399 260799009072 membrane protein P6; Region: PHA01399 260799009073 Phage-related minor tail protein [Function unknown]; Region: COG5280 260799009074 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 260799009075 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 260799009076 DsrH like protein; Region: DsrH; cl17347 260799009077 Bacteriophage HK97-gp10, putative tail-component; Region: HK97-gp10_like; pfam04883 260799009078 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 260799009079 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 260799009080 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 260799009081 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 260799009082 Phage capsid family; Region: Phage_capsid; pfam05065 260799009083 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 260799009084 Phage portal protein; Region: Phage_portal; cl19194 260799009085 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 260799009086 Phage Terminase; Region: Terminase_1; cl19862 260799009087 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 260799009088 active site 260799009089 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 260799009090 Helix-turn-helix domain; Region: HTH_17; pfam12728 260799009091 YtxH-like protein; Region: YtxH; cl02079 260799009092 WAX2 C-terminal domain; Region: Wax2_C; pfam12076 260799009093 HNH endonuclease; Region: HNH_2; pfam13391 260799009094 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 260799009095 homodimer interface [polypeptide binding]; other site 260799009096 chemical substrate binding site [chemical binding]; other site 260799009097 oligomer interface [polypeptide binding]; other site 260799009098 metal binding site [ion binding]; metal-binding site 260799009099 HB1, ASXL, restriction endonuclease HTH domain; Region: HARE-HTH; cl01319 260799009100 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 260799009101 active site 260799009102 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799009103 non-specific DNA binding site [nucleotide binding]; other site 260799009104 salt bridge; other site 260799009105 sequence-specific DNA binding site [nucleotide binding]; other site 260799009106 AIPR protein; Region: AIPR; pfam10592 260799009107 positive control sigma-like factor; Validated; Region: PRK06930 260799009108 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 260799009109 DNA binding residues [nucleotide binding] 260799009110 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 260799009111 Lecithin:cholesterol acyltransferase; Region: LCAT; pfam02450 260799009112 PGAP1-like protein; Region: PGAP1; pfam07819 260799009113 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 260799009114 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 260799009115 thymidylate synthase, flavin-dependent; Region: thyX; TIGR02170 260799009116 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cl19095 260799009117 cofactor binding site; other site 260799009118 DNA binding site [nucleotide binding] 260799009119 substrate interaction site [chemical binding]; other site 260799009120 dUTPase; Region: dUTPase_2; pfam08761 260799009121 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 260799009122 active site 260799009123 homodimer interface [polypeptide binding]; other site 260799009124 metal binding site [ion binding]; metal-binding site 260799009125 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 260799009126 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 260799009127 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799009128 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 260799009129 Walker A motif; other site 260799009130 ATP binding site [chemical binding]; other site 260799009131 Walker B motif; other site 260799009132 phage conserved hypothetical protein, C-terminal domain; Region: phg_TIGR02220 260799009133 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378 260799009134 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 260799009135 Domain of unknown function (DUF771); Region: DUF771; pfam05595 260799009136 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 260799009137 ORF6C domain; Region: ORF6C; pfam10552 260799009138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799009139 non-specific DNA binding site [nucleotide binding]; other site 260799009140 salt bridge; other site 260799009141 sequence-specific DNA binding site [nucleotide binding]; other site 260799009142 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 260799009143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799009144 non-specific DNA binding site [nucleotide binding]; other site 260799009145 salt bridge; other site 260799009146 sequence-specific DNA binding site [nucleotide binding]; other site 260799009147 Domain of unknown function (DUF955); Region: DUF955; cl01076 260799009148 glutamine synthetase, type I; Region: GlnA; TIGR00653 260799009149 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 260799009150 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 260799009151 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 260799009152 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 260799009153 DNA binding residues [nucleotide binding] 260799009154 putative dimer interface [polypeptide binding]; other site 260799009155 Methionine gamma-lyase; Region: Met_gamma_lyase; pfam06838 260799009156 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 260799009157 catalytic residue [active] 260799009158 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 260799009159 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 260799009160 HflX GTPase family; Region: HflX; cd01878 260799009161 G1 box; other site 260799009162 GTP/Mg2+ binding site [chemical binding]; other site 260799009163 Switch I region; other site 260799009164 G2 box; other site 260799009165 G3 box; other site 260799009166 Switch II region; other site 260799009167 G4 box; other site 260799009168 G5 box; other site 260799009169 Predicted membrane protein [Function unknown]; Region: COG2860 260799009170 UPF0126 domain; Region: UPF0126; pfam03458 260799009171 UPF0126 domain; Region: UPF0126; pfam03458 260799009172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799009173 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 260799009174 Walker A motif; other site 260799009175 ATP binding site [chemical binding]; other site 260799009176 Walker B motif; other site 260799009177 arginine finger; other site 260799009178 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_4; pfam13495 260799009179 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 260799009180 active site 260799009181 catalytic residues [active] 260799009182 DNA binding site [nucleotide binding] 260799009183 Int/Topo IB signature motif; other site 260799009184 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 260799009185 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 260799009186 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 260799009187 bacterial Hfq-like; Region: Hfq; cd01716 260799009188 hexamer interface [polypeptide binding]; other site 260799009189 Sm1 motif; other site 260799009190 RNA binding site [nucleotide binding]; other site 260799009191 Sm2 motif; other site 260799009192 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 260799009193 Bacterial SH3 domain; Region: SH3_3; pfam08239 260799009194 Bacterial SH3 domain homologues; Region: SH3b; smart00287 260799009195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 260799009196 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 260799009197 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 260799009198 active site 260799009199 phosphorylation site [posttranslational modification] 260799009200 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 260799009201 active site 260799009202 P-loop; other site 260799009203 phosphorylation site [posttranslational modification] 260799009204 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 260799009205 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 260799009206 putative substrate binding site [chemical binding]; other site 260799009207 putative ATP binding site [chemical binding]; other site 260799009208 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 260799009209 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 260799009210 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 260799009211 Predicted membrane protein [Function unknown]; Region: COG2322 260799009212 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 260799009213 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 260799009214 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 260799009215 Glyco_18 domain; Region: Glyco_18; smart00636 260799009216 putative active site [active] 260799009217 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 260799009218 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 260799009219 putative active site [active] 260799009220 putative metal binding site [ion binding]; other site 260799009221 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 260799009222 histone-like DNA-binding protein HU; Region: HU; cd13831 260799009223 dimer interface [polypeptide binding]; other site 260799009224 DNA binding site [nucleotide binding] 260799009225 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 260799009226 metal-binding site [ion binding] 260799009227 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 260799009228 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 260799009229 metal-binding site [ion binding] 260799009230 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 260799009231 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 260799009232 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 260799009233 metal-binding site [ion binding] 260799009234 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 260799009235 putative homodimer interface [polypeptide binding]; other site 260799009236 putative homotetramer interface [polypeptide binding]; other site 260799009237 putative allosteric switch controlling residues; other site 260799009238 putative metal binding site [ion binding]; other site 260799009239 putative homodimer-homodimer interface [polypeptide binding]; other site 260799009240 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 260799009241 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 260799009242 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 260799009243 Walker A/P-loop; other site 260799009244 ATP binding site [chemical binding]; other site 260799009245 Q-loop/lid; other site 260799009246 ABC transporter signature motif; other site 260799009247 Walker B; other site 260799009248 D-loop; other site 260799009249 H-loop/switch region; other site 260799009250 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 260799009251 ABC-ATPase subunit interface; other site 260799009252 dimer interface [polypeptide binding]; other site 260799009253 putative PBP binding regions; other site 260799009254 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 260799009255 ABC-ATPase subunit interface; other site 260799009256 dimer interface [polypeptide binding]; other site 260799009257 putative PBP binding regions; other site 260799009258 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 260799009259 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 260799009260 putative ligand binding residues [chemical binding]; other site 260799009261 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 260799009262 active site 260799009263 putative catalytic site [active] 260799009264 DNA binding site [nucleotide binding] 260799009265 putative phosphate binding site [ion binding]; other site 260799009266 metal binding site A [ion binding]; metal-binding site 260799009267 AP binding site [nucleotide binding]; other site 260799009268 metal binding site B [ion binding]; metal-binding site 260799009269 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 260799009270 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 260799009271 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 260799009272 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 260799009273 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 260799009274 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 260799009275 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 260799009276 DNA binding site [nucleotide binding] 260799009277 active site 260799009278 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 260799009279 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 260799009280 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 260799009281 minor groove reading motif; other site 260799009282 helix-hairpin-helix signature motif; other site 260799009283 substrate binding pocket [chemical binding]; other site 260799009284 active site 260799009285 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 260799009286 peptidase T-like protein; Region: PepT-like; TIGR01883 260799009287 metal binding site [ion binding]; metal-binding site 260799009288 dimer interface [polypeptide binding]; other site 260799009289 Predicted membrane protein [Function unknown]; Region: COG2364 260799009290 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 260799009291 hypothetical protein; Provisional; Region: PRK06764 260799009292 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 260799009293 catalytic core [active] 260799009294 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 260799009295 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799009296 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 260799009297 active site 260799009298 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 260799009299 PAS domain S-box; Region: sensory_box; TIGR00229 260799009300 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 260799009301 putative active site [active] 260799009302 heme pocket [chemical binding]; other site 260799009303 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 260799009304 metal binding site [ion binding]; metal-binding site 260799009305 active site 260799009306 I-site; other site 260799009307 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 260799009308 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 260799009309 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 260799009310 LrgB-like family; Region: LrgB; cl00596 260799009311 holin-like protein; Validated; Region: PRK01658 260799009312 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 260799009313 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 260799009314 DNA-binding site [nucleotide binding]; DNA binding site 260799009315 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 260799009316 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799009317 homodimer interface [polypeptide binding]; other site 260799009318 catalytic residue [active] 260799009319 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799009320 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 260799009321 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 260799009322 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 260799009323 active site 260799009324 catalytic site [active] 260799009325 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 260799009326 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 260799009327 putative active site [active] 260799009328 putative catalytic triad [active] 260799009329 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 260799009330 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 260799009331 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 260799009332 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 260799009333 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 260799009334 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 260799009335 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 260799009336 Sulfatase; Region: Sulfatase; pfam00884 260799009337 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799009338 binding surface 260799009339 Tetratricopeptide repeat; Region: TPR_16; pfam13432 260799009340 TPR motif; other site 260799009341 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 260799009342 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 260799009343 G1 box; other site 260799009344 GTP/Mg2+ binding site [chemical binding]; other site 260799009345 Switch I region; other site 260799009346 G3 box; other site 260799009347 Switch II region; other site 260799009348 G4 box; other site 260799009349 G5 box; other site 260799009350 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 260799009351 active site 260799009352 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799009353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799009354 dimer interface [polypeptide binding]; other site 260799009355 phosphorylation site [posttranslational modification] 260799009356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799009357 ATP binding site [chemical binding]; other site 260799009358 Mg2+ binding site [ion binding]; other site 260799009359 G-X-G motif; other site 260799009360 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799009361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799009362 active site 260799009363 phosphorylation site [posttranslational modification] 260799009364 intermolecular recognition site; other site 260799009365 dimerization interface [polypeptide binding]; other site 260799009366 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799009367 DNA binding site [nucleotide binding] 260799009368 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 260799009369 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 260799009370 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 260799009371 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 260799009372 Walker A/P-loop; other site 260799009373 ATP binding site [chemical binding]; other site 260799009374 Q-loop/lid; other site 260799009375 ABC transporter signature motif; other site 260799009376 Walker B; other site 260799009377 D-loop; other site 260799009378 H-loop/switch region; other site 260799009379 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 260799009380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799009381 ATP binding site [chemical binding]; other site 260799009382 Mg2+ binding site [ion binding]; other site 260799009383 G-X-G motif; other site 260799009384 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 260799009385 ATP binding site [chemical binding]; other site 260799009386 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 260799009387 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 260799009388 MutS domain I; Region: MutS_I; pfam01624 260799009389 MutS domain II; Region: MutS_II; pfam05188 260799009390 MutS domain III; Region: MutS_III; pfam05192 260799009391 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 260799009392 Walker A/P-loop; other site 260799009393 ATP binding site [chemical binding]; other site 260799009394 Q-loop/lid; other site 260799009395 ABC transporter signature motif; other site 260799009396 Walker B; other site 260799009397 D-loop; other site 260799009398 H-loop/switch region; other site 260799009399 Outer spore coat protein E (CotE); Region: CotE; pfam10628 260799009400 Predicted membrane protein [Function unknown]; Region: COG4550 260799009401 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 260799009402 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 260799009403 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 260799009404 FeS/SAM binding site; other site 260799009405 TRAM domain; Region: TRAM; pfam01938 260799009406 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 260799009407 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 260799009408 TPP-binding site [chemical binding]; other site 260799009409 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 260799009410 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 260799009411 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 260799009412 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 260799009413 dimer interface [polypeptide binding]; other site 260799009414 PYR/PP interface [polypeptide binding]; other site 260799009415 TPP binding site [chemical binding]; other site 260799009416 substrate binding site [chemical binding]; other site 260799009417 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 260799009418 active site 260799009419 dimer interface [polypeptide binding]; other site 260799009420 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 260799009421 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 260799009422 putative active site [active] 260799009423 metal binding site [ion binding]; metal-binding site 260799009424 homodimer binding site [polypeptide binding]; other site 260799009425 phosphodiesterase; Provisional; Region: PRK12704 260799009426 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 260799009427 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 260799009428 KH domain; Region: KH_1; pfam00013 260799009429 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 260799009430 Zn2+ binding site [ion binding]; other site 260799009431 Mg2+ binding site [ion binding]; other site 260799009432 recombinase A; Provisional; Region: recA; PRK09354 260799009433 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 260799009434 hexamer interface [polypeptide binding]; other site 260799009435 Walker A motif; other site 260799009436 ATP binding site [chemical binding]; other site 260799009437 Walker B motif; other site 260799009438 competence damage-inducible protein A; Provisional; Region: PRK00549 260799009439 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 260799009440 putative MPT binding site; other site 260799009441 Competence-damaged protein; Region: CinA; pfam02464 260799009442 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 260799009443 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 260799009444 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799009445 non-specific DNA binding site [nucleotide binding]; other site 260799009446 salt bridge; other site 260799009447 sequence-specific DNA binding site [nucleotide binding]; other site 260799009448 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 260799009449 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 260799009450 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 260799009451 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 260799009452 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 260799009453 classical (c) SDRs; Region: SDR_c; cd05233 260799009454 NAD(P) binding site [chemical binding]; other site 260799009455 active site 260799009456 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 260799009457 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 260799009458 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 260799009459 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 260799009460 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 260799009461 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 260799009462 TM-ABC transporter signature motif; other site 260799009463 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 260799009464 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 260799009465 Walker A/P-loop; other site 260799009466 ATP binding site [chemical binding]; other site 260799009467 Q-loop/lid; other site 260799009468 ABC transporter signature motif; other site 260799009469 Walker B; other site 260799009470 D-loop; other site 260799009471 H-loop/switch region; other site 260799009472 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 260799009473 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 260799009474 ligand binding site [chemical binding]; other site 260799009475 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 260799009476 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 260799009477 DNA-binding site [nucleotide binding]; DNA binding site 260799009478 UTRA domain; Region: UTRA; pfam07702 260799009479 Tetraspanin family; Region: Tetraspannin; pfam00335 260799009480 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 260799009481 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 260799009482 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 260799009483 YlzJ-like protein; Region: YlzJ; pfam14035 260799009484 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 260799009485 active site 260799009486 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 260799009487 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 260799009488 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 260799009489 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 260799009490 dimer interface [polypeptide binding]; other site 260799009491 active site 260799009492 catalytic residue [active] 260799009493 aspartate kinase I; Reviewed; Region: PRK08210 260799009494 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 260799009495 nucleotide binding site [chemical binding]; other site 260799009496 substrate binding site [chemical binding]; other site 260799009497 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 260799009498 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 260799009499 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 260799009500 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 260799009501 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 260799009502 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 260799009503 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 260799009504 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; cl19125 260799009505 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 260799009506 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 260799009507 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 260799009508 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 260799009509 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 260799009510 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 260799009511 NodB motif; other site 260799009512 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 260799009513 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 260799009514 RNase E interface [polypeptide binding]; other site 260799009515 trimer interface [polypeptide binding]; other site 260799009516 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 260799009517 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 260799009518 RNase E interface [polypeptide binding]; other site 260799009519 trimer interface [polypeptide binding]; other site 260799009520 active site 260799009521 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 260799009522 putative nucleic acid binding region [nucleotide binding]; other site 260799009523 G-X-X-G motif; other site 260799009524 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 260799009525 RNA binding site [nucleotide binding]; other site 260799009526 domain interface; other site 260799009527 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 260799009528 16S/18S rRNA binding site [nucleotide binding]; other site 260799009529 S13e-L30e interaction site [polypeptide binding]; other site 260799009530 25S rRNA binding site [nucleotide binding]; other site 260799009531 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 260799009532 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 260799009533 active site 260799009534 Riboflavin kinase; Region: Flavokinase; smart00904 260799009535 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 260799009536 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 260799009537 RNA binding site [nucleotide binding]; other site 260799009538 active site 260799009539 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 260799009540 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 260799009541 Protein of unknown function (DUF503); Region: DUF503; pfam04456 260799009542 translation initiation factor IF-2; Validated; Region: infB; PRK05306 260799009543 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 260799009544 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 260799009545 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 260799009546 G1 box; other site 260799009547 putative GEF interaction site [polypeptide binding]; other site 260799009548 GTP/Mg2+ binding site [chemical binding]; other site 260799009549 Switch I region; other site 260799009550 G2 box; other site 260799009551 G3 box; other site 260799009552 Switch II region; other site 260799009553 G4 box; other site 260799009554 G5 box; other site 260799009555 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 260799009556 Translation-initiation factor 2; Region: IF-2; pfam11987 260799009557 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 260799009558 hypothetical protein; Provisional; Region: PRK07714 260799009559 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 260799009560 putative RNA binding cleft [nucleotide binding]; other site 260799009561 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 260799009562 NusA N-terminal domain; Region: NusA_N; pfam08529 260799009563 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 260799009564 RNA binding site [nucleotide binding]; other site 260799009565 homodimer interface [polypeptide binding]; other site 260799009566 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 260799009567 G-X-X-G motif; other site 260799009568 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 260799009569 G-X-X-G motif; other site 260799009570 Sm and related proteins; Region: Sm_like; cl00259 260799009571 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 260799009572 putative oligomer interface [polypeptide binding]; other site 260799009573 putative RNA binding site [nucleotide binding]; other site 260799009574 DNA polymerase III PolC; Validated; Region: polC; PRK00448 260799009575 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480 260799009576 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 260799009577 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 260799009578 generic binding surface II; other site 260799009579 generic binding surface I; other site 260799009580 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 260799009581 active site 260799009582 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 260799009583 active site 260799009584 catalytic site [active] 260799009585 substrate binding site [chemical binding]; other site 260799009586 putative PHP Thumb interface [polypeptide binding]; other site 260799009587 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 260799009588 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 260799009589 prolyl-tRNA synthetase; Provisional; Region: PRK09194 260799009590 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 260799009591 dimer interface [polypeptide binding]; other site 260799009592 motif 1; other site 260799009593 active site 260799009594 motif 2; other site 260799009595 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 260799009596 putative deacylase active site [active] 260799009597 motif 3; other site 260799009598 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 260799009599 anticodon binding site; other site 260799009600 RIP metalloprotease RseP; Region: TIGR00054 260799009601 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 260799009602 active site 260799009603 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 260799009604 protein binding site [polypeptide binding]; other site 260799009605 putative substrate binding region [chemical binding]; other site 260799009606 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 260799009607 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 260799009608 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 260799009609 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 260799009610 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 260799009611 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 260799009612 active site 260799009613 dimer interface [polypeptide binding]; other site 260799009614 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 260799009615 hinge region; other site 260799009616 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 260799009617 putative nucleotide binding site [chemical binding]; other site 260799009618 uridine monophosphate binding site [chemical binding]; other site 260799009619 homohexameric interface [polypeptide binding]; other site 260799009620 elongation factor Ts; Provisional; Region: tsf; PRK09377 260799009621 UBA/TS-N domain; Region: UBA; pfam00627 260799009622 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 260799009623 rRNA interaction site [nucleotide binding]; other site 260799009624 S8 interaction site; other site 260799009625 putative laminin-1 binding site; other site 260799009626 transcriptional repressor CodY; Validated; Region: PRK04158 260799009627 CodY GAF-like domain; Region: CodY; pfam06018 260799009628 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 260799009629 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 260799009630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799009631 Walker A motif; other site 260799009632 ATP binding site [chemical binding]; other site 260799009633 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 260799009634 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 260799009635 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 260799009636 active site 260799009637 HslU subunit interaction site [polypeptide binding]; other site 260799009638 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 260799009639 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 260799009640 active site 260799009641 Int/Topo IB signature motif; other site 260799009642 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 260799009643 Glucose inhibited division protein A; Region: GIDA; pfam01134 260799009644 DNA topoisomerase I; Validated; Region: PRK05582 260799009645 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 260799009646 active site 260799009647 interdomain interaction site; other site 260799009648 putative metal-binding site [ion binding]; other site 260799009649 nucleotide binding site [chemical binding]; other site 260799009650 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 260799009651 domain I; other site 260799009652 DNA binding groove [nucleotide binding] 260799009653 phosphate binding site [ion binding]; other site 260799009654 domain II; other site 260799009655 domain III; other site 260799009656 nucleotide binding site [chemical binding]; other site 260799009657 catalytic site [active] 260799009658 domain IV; other site 260799009659 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 260799009660 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 260799009661 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 260799009662 CoA binding domain; Region: CoA_binding; pfam02629 260799009663 CoA-ligase; Region: Ligase_CoA; pfam00549 260799009664 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 260799009665 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 260799009666 CoA-ligase; Region: Ligase_CoA; pfam00549 260799009667 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 260799009668 RNA/DNA hybrid binding site [nucleotide binding]; other site 260799009669 active site 260799009670 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 260799009671 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 260799009672 GTP/Mg2+ binding site [chemical binding]; other site 260799009673 G4 box; other site 260799009674 G5 box; other site 260799009675 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 260799009676 G1 box; other site 260799009677 G1 box; other site 260799009678 GTP/Mg2+ binding site [chemical binding]; other site 260799009679 Switch I region; other site 260799009680 G2 box; other site 260799009681 G2 box; other site 260799009682 G3 box; other site 260799009683 G3 box; other site 260799009684 Switch II region; other site 260799009685 Switch II region; other site 260799009686 G4 box; other site 260799009687 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 260799009688 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 260799009689 Catalytic site [active] 260799009690 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 260799009691 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 260799009692 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 260799009693 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 260799009694 RimM N-terminal domain; Region: RimM; pfam01782 260799009695 PRC-barrel domain; Region: PRC; pfam05239 260799009696 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 260799009697 G-X-X-G motif; other site 260799009698 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 260799009699 signal recognition particle protein; Provisional; Region: PRK10867 260799009700 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 260799009701 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 260799009702 P loop; other site 260799009703 GTP binding site [chemical binding]; other site 260799009704 Signal peptide binding domain; Region: SRP_SPB; pfam02978 260799009705 putative DNA-binding protein; Validated; Region: PRK00118 260799009706 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 260799009707 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 260799009708 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 260799009709 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 260799009710 P loop; other site 260799009711 GTP binding site [chemical binding]; other site 260799009712 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 260799009713 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 260799009714 Walker A/P-loop; other site 260799009715 ATP binding site [chemical binding]; other site 260799009716 Q-loop/lid; other site 260799009717 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 260799009718 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 260799009719 ABC transporter signature motif; other site 260799009720 Walker B; other site 260799009721 D-loop; other site 260799009722 H-loop/switch region; other site 260799009723 ribonuclease III; Reviewed; Region: rnc; PRK00102 260799009724 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 260799009725 dimerization interface [polypeptide binding]; other site 260799009726 active site 260799009727 metal binding site [ion binding]; metal-binding site 260799009728 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 260799009729 dsRNA binding site [nucleotide binding]; other site 260799009730 acyl carrier protein; Provisional; Region: acpP; PRK00982 260799009731 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 260799009732 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 260799009733 NAD(P) binding site [chemical binding]; other site 260799009734 homotetramer interface [polypeptide binding]; other site 260799009735 homodimer interface [polypeptide binding]; other site 260799009736 active site 260799009737 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 260799009738 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 260799009739 putative phosphate acyltransferase; Provisional; Region: PRK05331 260799009740 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 260799009741 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 260799009742 active site 2 [active] 260799009743 active site 1 [active] 260799009744 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 260799009745 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 260799009746 generic binding surface II; other site 260799009747 ssDNA binding site; other site 260799009748 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 260799009749 ATP binding site [chemical binding]; other site 260799009750 putative Mg++ binding site [ion binding]; other site 260799009751 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 260799009752 nucleotide binding region [chemical binding]; other site 260799009753 ATP-binding site [chemical binding]; other site 260799009754 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 260799009755 DAK2 domain; Region: Dak2; pfam02734 260799009756 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 260799009757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 260799009758 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 260799009759 Thiamine pyrophosphokinase; Region: TPK; cd07995 260799009760 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 260799009761 active site 260799009762 dimerization interface [polypeptide binding]; other site 260799009763 thiamine binding site [chemical binding]; other site 260799009764 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 260799009765 substrate binding site [chemical binding]; other site 260799009766 hexamer interface [polypeptide binding]; other site 260799009767 metal binding site [ion binding]; metal-binding site 260799009768 GTPase RsgA; Reviewed; Region: PRK00098 260799009769 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 260799009770 RNA binding site [nucleotide binding]; other site 260799009771 homodimer interface [polypeptide binding]; other site 260799009772 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 260799009773 GTPase/Zn-binding domain interface [polypeptide binding]; other site 260799009774 GTP/Mg2+ binding site [chemical binding]; other site 260799009775 G4 box; other site 260799009776 G5 box; other site 260799009777 G1 box; other site 260799009778 Switch I region; other site 260799009779 G2 box; other site 260799009780 G3 box; other site 260799009781 Switch II region; other site 260799009782 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 260799009783 Catalytic domain of Protein Kinases; Region: PKc; cd00180 260799009784 active site 260799009785 ATP binding site [chemical binding]; other site 260799009786 substrate binding site [chemical binding]; other site 260799009787 activation loop (A-loop); other site 260799009788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 260799009789 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 260799009790 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 260799009791 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 260799009792 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 260799009793 active site 260799009794 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 260799009795 23S rRNA m2A2503 methyltransferase; Region: TIGR00048 260799009796 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 260799009797 FeS/SAM binding site; other site 260799009798 16S rRNA methyltransferase B; Provisional; Region: PRK14902 260799009799 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 260799009800 putative RNA binding site [nucleotide binding]; other site 260799009801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799009802 S-adenosylmethionine binding site [chemical binding]; other site 260799009803 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 260799009804 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 260799009805 putative active site [active] 260799009806 substrate binding site [chemical binding]; other site 260799009807 putative cosubstrate binding site; other site 260799009808 catalytic site [active] 260799009809 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 260799009810 substrate binding site [chemical binding]; other site 260799009811 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 260799009812 active site 260799009813 catalytic residues [active] 260799009814 metal binding site [ion binding]; metal-binding site 260799009815 primosome assembly protein PriA; Validated; Region: PRK05580 260799009816 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 260799009817 ATP binding site [chemical binding]; other site 260799009818 putative Mg++ binding site [ion binding]; other site 260799009819 helicase superfamily c-terminal domain; Region: HELICc; smart00490 260799009820 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 260799009821 Flavoprotein; Region: Flavoprotein; cl19190 260799009822 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 260799009823 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 260799009824 Guanylate kinase; Region: Guanylate_kin; pfam00625 260799009825 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 260799009826 catalytic site [active] 260799009827 G-X2-G-X-G-K; other site 260799009828 hypothetical protein; Provisional; Region: PRK04323 260799009829 hypothetical protein; Provisional; Region: PRK11820 260799009830 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 260799009831 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 260799009832 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 260799009833 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 260799009834 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 260799009835 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 260799009836 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799009837 motif II; other site 260799009838 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 260799009839 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 260799009840 Domain of unknown function (DUF814); Region: DUF814; pfam05670 260799009841 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 260799009842 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 260799009843 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 260799009844 active site 260799009845 YoqO-like protein; Region: YoqO; pfam14037 260799009846 YoqO-like protein; Region: YoqO; pfam14037 260799009847 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 260799009848 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 260799009849 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 260799009850 active site 260799009851 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 260799009852 active site 260799009853 dimer interface [polypeptide binding]; other site 260799009854 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 260799009855 heterodimer interface [polypeptide binding]; other site 260799009856 active site 260799009857 FMN binding site [chemical binding]; other site 260799009858 homodimer interface [polypeptide binding]; other site 260799009859 substrate binding site [chemical binding]; other site 260799009860 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 260799009861 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 260799009862 FAD binding pocket [chemical binding]; other site 260799009863 FAD binding motif [chemical binding]; other site 260799009864 phosphate binding motif [ion binding]; other site 260799009865 beta-alpha-beta structure motif; other site 260799009866 NAD binding pocket [chemical binding]; other site 260799009867 Iron coordination center [ion binding]; other site 260799009868 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 260799009869 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 260799009870 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 260799009871 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 260799009872 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 260799009873 ATP-grasp domain; Region: ATP-grasp_4; cl17255 260799009874 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 260799009875 IMP binding site; other site 260799009876 dimer interface [polypeptide binding]; other site 260799009877 interdomain contacts; other site 260799009878 partial ornithine binding site; other site 260799009879 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 260799009880 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 260799009881 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 260799009882 catalytic site [active] 260799009883 subunit interface [polypeptide binding]; other site 260799009884 dihydroorotase; Validated; Region: pyrC; PRK09357 260799009885 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 260799009886 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 260799009887 active site 260799009888 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 260799009889 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 260799009890 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 260799009891 Sulfate transporter family; Region: Sulfate_transp; cl19250 260799009892 uracil-xanthine permease; Region: ncs2; TIGR00801 260799009893 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 260799009894 active site 260799009895 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 260799009896 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 260799009897 RNA binding surface [nucleotide binding]; other site 260799009898 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 260799009899 active site 260799009900 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 260799009901 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 260799009902 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 260799009903 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 260799009904 active site 260799009905 HIGH motif; other site 260799009906 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 260799009907 KMSKS motif; other site 260799009908 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 260799009909 tRNA binding surface [nucleotide binding]; other site 260799009910 anticodon binding site; other site 260799009911 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 260799009912 DivIVA protein; Region: DivIVA; pfam05103 260799009913 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 260799009914 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 260799009915 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 260799009916 RNA binding surface [nucleotide binding]; other site 260799009917 YGGT family; Region: YGGT; pfam02325 260799009918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 260799009919 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 260799009920 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 260799009921 catalytic residue [active] 260799009922 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 260799009923 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 260799009924 sporulation sigma factor SigG; Reviewed; Region: PRK08215 260799009925 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799009926 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 260799009927 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 260799009928 DNA binding residues [nucleotide binding] 260799009929 sporulation sigma factor SigE; Reviewed; Region: PRK08301 260799009930 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799009931 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 260799009932 DNA binding residues [nucleotide binding] 260799009933 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 260799009934 cell division protein FtsZ; Validated; Region: PRK09330 260799009935 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 260799009936 nucleotide binding site [chemical binding]; other site 260799009937 SulA interaction site; other site 260799009938 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 260799009939 Cell division protein FtsA; Region: FtsA; smart00842 260799009940 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 260799009941 nucleotide binding site [chemical binding]; other site 260799009942 Cell division protein FtsA; Region: FtsA; pfam14450 260799009943 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 260799009944 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 260799009945 Cell division protein FtsQ; Region: FtsQ; pfam03799 260799009946 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 260799009947 FAD binding domain; Region: FAD_binding_4; pfam01565 260799009948 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 260799009949 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 260799009950 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 260799009951 active site 260799009952 homodimer interface [polypeptide binding]; other site 260799009953 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 260799009954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 260799009955 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 260799009956 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 260799009957 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 260799009958 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 260799009959 Mg++ binding site [ion binding]; other site 260799009960 putative catalytic motif [active] 260799009961 putative substrate binding site [chemical binding]; other site 260799009962 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 260799009963 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 260799009964 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 260799009965 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 260799009966 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 260799009967 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 260799009968 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 260799009969 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 260799009970 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 260799009971 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 260799009972 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 260799009973 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 260799009974 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 260799009975 Cell division protein FtsL; Region: FtsL; cl11433 260799009976 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 260799009977 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 260799009978 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 260799009979 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 260799009980 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 260799009981 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799009982 Coenzyme A binding pocket [chemical binding]; other site 260799009983 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 260799009984 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 260799009985 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 260799009986 Replication-relaxation; Region: Replic_Relax; pfam13814 260799009987 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 260799009988 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799009989 non-specific DNA binding site [nucleotide binding]; other site 260799009990 salt bridge; other site 260799009991 sequence-specific DNA binding site [nucleotide binding]; other site 260799009992 hypothetical protein; Region: PHA02436 260799009993 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 260799009994 amidase catalytic site [active] 260799009995 Zn binding residues [ion binding]; other site 260799009996 substrate binding site [chemical binding]; other site 260799009997 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 260799009998 Holin family; Region: Phage_holin_4; pfam05105 260799009999 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 260799010000 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 260799010001 active site 260799010002 catalytic residues [active] 260799010003 DNA binding site [nucleotide binding] 260799010004 Int/Topo IB signature motif; other site 260799010005 Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582 260799010006 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 260799010007 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl19174 260799010008 Trypanosomal VSG domain; Region: VSG_B; pfam13206 260799010009 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 260799010010 putative phage tail component, N-terminal domain; Region: phi3626_gp14_N; TIGR01633 260799010011 Phage tail protein; Region: Sipho_tail; cl17486 260799010012 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cd00176 260799010013 linker region; other site 260799010014 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 260799010015 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 260799010016 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 260799010017 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 260799010018 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 260799010019 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 260799010020 oligomerization interface [polypeptide binding]; other site 260799010021 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 260799010022 Interdomain contacts; other site 260799010023 Cytokine receptor motif; other site 260799010024 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 260799010025 Phage capsid family; Region: Phage_capsid; pfam05065 260799010026 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 260799010027 oligomer interface [polypeptide binding]; other site 260799010028 active site residues [active] 260799010029 Phage portal protein; Region: Phage_portal; pfam04860 260799010030 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 260799010031 Phage Terminase; Region: Terminase_1; cl19862 260799010032 Phage terminase, small subunit; Region: Terminase_4; pfam05119 260799010033 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 260799010034 active site 260799010035 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137 260799010036 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 260799010037 Int/Topo IB signature motif; other site 260799010038 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 260799010039 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 260799010040 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799010041 non-specific DNA binding site [nucleotide binding]; other site 260799010042 salt bridge; other site 260799010043 sequence-specific DNA binding site [nucleotide binding]; other site 260799010044 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 260799010045 active site 260799010046 metal binding site [ion binding]; metal-binding site 260799010047 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 260799010048 trimer interface [polypeptide binding]; other site 260799010049 active site 260799010050 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 260799010051 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799010052 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799010053 sequence-specific DNA binding site [nucleotide binding]; other site 260799010054 salt bridge; other site 260799010055 Helix-turn-helix domain; Region: HTH_38; pfam13936 260799010056 hypothetical protein; Validated; Region: PRK08116 260799010057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799010058 Walker A motif; other site 260799010059 ATP binding site [chemical binding]; other site 260799010060 Walker B motif; other site 260799010061 Helix-turn-helix domain; Region: HTH_36; pfam13730 260799010062 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 260799010063 Helix-turn-helix domain; Region: HTH_17; pfam12728 260799010064 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799010065 non-specific DNA binding site [nucleotide binding]; other site 260799010066 salt bridge; other site 260799010067 sequence-specific DNA binding site [nucleotide binding]; other site 260799010068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799010069 non-specific DNA binding site [nucleotide binding]; other site 260799010070 salt bridge; other site 260799010071 sequence-specific DNA binding site [nucleotide binding]; other site 260799010072 V-type ATP synthase subunit I; Validated; Region: PRK05771 260799010073 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 260799010074 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799010075 non-specific DNA binding site [nucleotide binding]; other site 260799010076 salt bridge; other site 260799010077 sequence-specific DNA binding site [nucleotide binding]; other site 260799010078 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 260799010079 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 260799010080 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 260799010081 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 260799010082 Int/Topo IB signature motif; other site 260799010083 hypothetical protein; Provisional; Region: PRK13670 260799010084 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 260799010085 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 260799010086 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 260799010087 protein binding site [polypeptide binding]; other site 260799010088 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 260799010089 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 260799010090 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 260799010091 active site 260799010092 nucleophile elbow; other site 260799010093 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 260799010094 Nucleoside recognition; Region: Gate; pfam07670 260799010095 Nucleoside recognition; Region: Gate; pfam07670 260799010096 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 260799010097 active site 260799010098 (T/H)XGH motif; other site 260799010099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799010100 S-adenosylmethionine binding site [chemical binding]; other site 260799010101 hypothetical protein; Provisional; Region: PRK02886 260799010102 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 260799010103 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 260799010104 catalytic core [active] 260799010105 YlbE-like protein; Region: YlbE; pfam14003 260799010106 Putative coat protein; Region: YlbD_coat; pfam14071 260799010107 CAP-associated N-terminal; Region: CAP_assoc_N; pfam14504 260799010108 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 260799010109 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 260799010110 YugN-like family; Region: YugN; pfam08868 260799010111 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 260799010112 multimer interface [polypeptide binding]; other site 260799010113 active site 260799010114 catalytic triad [active] 260799010115 dimer interface [polypeptide binding]; other site 260799010116 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 260799010117 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 260799010118 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 260799010119 Subunit I/III interface [polypeptide binding]; other site 260799010120 Subunit III/IV interface [polypeptide binding]; other site 260799010121 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 260799010122 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 260799010123 D-pathway; other site 260799010124 Putative ubiquinol binding site [chemical binding]; other site 260799010125 Low-spin heme (heme b) binding site [chemical binding]; other site 260799010126 Putative water exit pathway; other site 260799010127 Binuclear center (heme o3/CuB) [ion binding]; other site 260799010128 K-pathway; other site 260799010129 Putative proton exit pathway; other site 260799010130 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 260799010131 The cupredoxin domain of Caa3 type Cytochrome c oxidase subunit II; Region: CuRO_CcO_Caa3_II; cd04213 260799010132 oligomer interface [polypeptide binding]; other site 260799010133 CuA binuclear center [ion binding]; other site 260799010134 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 260799010135 Cytochrome c; Region: Cytochrom_C; pfam00034 260799010136 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 260799010137 putative active site [active] 260799010138 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 260799010139 pyruvate carboxylase; Reviewed; Region: PRK12999 260799010140 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 260799010141 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 260799010142 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 260799010143 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 260799010144 active site 260799010145 catalytic residues [active] 260799010146 metal binding site [ion binding]; metal-binding site 260799010147 homodimer binding site [polypeptide binding]; other site 260799010148 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 260799010149 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 260799010150 carboxyltransferase (CT) interaction site; other site 260799010151 biotinylation site [posttranslational modification]; other site 260799010152 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 260799010153 hypothetical protein; Provisional; Region: PRK13666 260799010154 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 260799010155 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 260799010156 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 260799010157 putative active site [active] 260799010158 PhoH-like protein; Region: PhoH; pfam02562 260799010159 hypothetical protein; Provisional; Region: PRK06733 260799010160 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 260799010161 YlaH-like protein; Region: YlaH; pfam14036 260799010162 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 260799010163 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 260799010164 G1 box; other site 260799010165 putative GEF interaction site [polypeptide binding]; other site 260799010166 GTP/Mg2+ binding site [chemical binding]; other site 260799010167 Switch I region; other site 260799010168 G2 box; other site 260799010169 G3 box; other site 260799010170 Switch II region; other site 260799010171 G4 box; other site 260799010172 G5 box; other site 260799010173 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 260799010174 Elongation Factor G, domain II; Region: EFG_II; pfam14492 260799010175 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 260799010176 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 260799010177 active site 260799010178 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 260799010179 hypothetical protein; Provisional; Region: PRK04387 260799010180 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 260799010181 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 260799010182 homodimer interface [polypeptide binding]; other site 260799010183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799010184 catalytic residue [active] 260799010185 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 260799010186 transglutaminase; Provisional; Region: tgl; PRK03187 260799010187 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 260799010188 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 260799010189 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 260799010190 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 260799010191 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 260799010192 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 260799010193 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 260799010194 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 260799010195 E3 interaction surface; other site 260799010196 lipoyl attachment site [posttranslational modification]; other site 260799010197 e3 binding domain; Region: E3_binding; pfam02817 260799010198 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 260799010199 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 260799010200 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 260799010201 alpha subunit interface [polypeptide binding]; other site 260799010202 TPP binding site [chemical binding]; other site 260799010203 heterodimer interface [polypeptide binding]; other site 260799010204 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 260799010205 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 260799010206 TPP-binding site [chemical binding]; other site 260799010207 heterodimer interface [polypeptide binding]; other site 260799010208 tetramer interface [polypeptide binding]; other site 260799010209 phosphorylation loop region [posttranslational modification] 260799010210 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 260799010211 active site 260799010212 catalytic residues [active] 260799010213 metal binding site [ion binding]; metal-binding site 260799010214 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 260799010215 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799010216 active site 260799010217 motif I; other site 260799010218 motif II; other site 260799010219 hypothetical protein; Provisional; Region: PRK13667 260799010220 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 260799010221 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 260799010222 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 260799010223 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 260799010224 TrkA-N domain; Region: TrkA_N; pfam02254 260799010225 TrkA-C domain; Region: TrkA_C; pfam02080 260799010226 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 260799010227 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 260799010228 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 260799010229 metal binding site [ion binding]; metal-binding site 260799010230 putative dimer interface [polypeptide binding]; other site 260799010231 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 260799010232 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 260799010233 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 260799010234 trimer interface [polypeptide binding]; other site 260799010235 active site 260799010236 substrate binding site [chemical binding]; other site 260799010237 CoA binding site [chemical binding]; other site 260799010238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 260799010239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 260799010240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 260799010241 dimerization interface [polypeptide binding]; other site 260799010242 FOG: CBS domain [General function prediction only]; Region: COG0517 260799010243 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 260799010244 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 260799010245 Protein of unknown function (DUF458); Region: DUF458; pfam04308 260799010246 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 260799010247 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 260799010248 catalytic residues [active] 260799010249 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 260799010250 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 260799010251 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 260799010252 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 260799010253 short chain dehydrogenase; Provisional; Region: PRK07677 260799010254 NAD(P) binding site [chemical binding]; other site 260799010255 substrate binding site [chemical binding]; other site 260799010256 homotetramer interface [polypeptide binding]; other site 260799010257 active site 260799010258 homodimer interface [polypeptide binding]; other site 260799010259 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 260799010260 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 260799010261 putative active site [active] 260799010262 putative metal binding site [ion binding]; other site 260799010263 polyphosphate kinase; Provisional; Region: PRK05443 260799010264 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 260799010265 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 260799010266 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 260799010267 putative domain interface [polypeptide binding]; other site 260799010268 putative active site [active] 260799010269 catalytic site [active] 260799010270 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 260799010271 putative domain interface [polypeptide binding]; other site 260799010272 putative active site [active] 260799010273 catalytic site [active] 260799010274 exopolyphosphatase; Region: exo_poly_only; TIGR03706 260799010275 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 260799010276 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 260799010277 nucleotide binding site [chemical binding]; other site 260799010278 YkyB-like protein; Region: YkyB; pfam14177 260799010279 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 260799010280 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 260799010281 metal binding site [ion binding]; metal-binding site 260799010282 Phage lysis protein, holin; Region: Phage_holin; cl04675 260799010283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799010284 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799010285 putative substrate translocation pore; other site 260799010286 Predicted transcriptional regulators [Transcription]; Region: COG1695 260799010287 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 260799010288 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 260799010289 THF binding site; other site 260799010290 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 260799010291 substrate binding site [chemical binding]; other site 260799010292 THF binding site; other site 260799010293 zinc-binding site [ion binding]; other site 260799010294 Competence protein J (ComJ); Region: ComJ; pfam11033 260799010295 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 260799010296 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 260799010297 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799010298 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799010299 dimer interface [polypeptide binding]; other site 260799010300 phosphorylation site [posttranslational modification] 260799010301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799010302 ATP binding site [chemical binding]; other site 260799010303 Mg2+ binding site [ion binding]; other site 260799010304 G-X-G motif; other site 260799010305 aminotransferase A; Validated; Region: PRK07683 260799010306 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 260799010307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799010308 homodimer interface [polypeptide binding]; other site 260799010309 catalytic residue [active] 260799010310 Transcriptional regulators [Transcription]; Region: PurR; COG1609 260799010311 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 260799010312 DNA binding site [nucleotide binding] 260799010313 domain linker motif; other site 260799010314 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 260799010315 putative dimerization interface [polypeptide binding]; other site 260799010316 putative ligand binding site [chemical binding]; other site 260799010317 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 260799010318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799010319 dimer interface [polypeptide binding]; other site 260799010320 conserved gate region; other site 260799010321 putative PBP binding loops; other site 260799010322 ABC-ATPase subunit interface; other site 260799010323 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 260799010324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799010325 dimer interface [polypeptide binding]; other site 260799010326 conserved gate region; other site 260799010327 putative PBP binding loops; other site 260799010328 ABC-ATPase subunit interface; other site 260799010329 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 260799010330 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 260799010331 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 260799010332 homodimer interface [polypeptide binding]; other site 260799010333 maltodextrin glucosidase; Provisional; Region: PRK10785 260799010334 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 260799010335 active site 260799010336 homodimer interface [polypeptide binding]; other site 260799010337 catalytic site [active] 260799010338 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 260799010339 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 260799010340 Ca binding site [ion binding]; other site 260799010341 active site 260799010342 catalytic site [active] 260799010343 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 260799010344 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 260799010345 Walker A/P-loop; other site 260799010346 ATP binding site [chemical binding]; other site 260799010347 Q-loop/lid; other site 260799010348 ABC transporter signature motif; other site 260799010349 Walker B; other site 260799010350 D-loop; other site 260799010351 H-loop/switch region; other site 260799010352 TOBE domain; Region: TOBE_2; pfam08402 260799010353 hypothetical protein; Provisional; Region: PRK06720 260799010354 NAD(P) binding site [chemical binding]; other site 260799010355 RDD family; Region: RDD; pfam06271 260799010356 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 260799010357 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 260799010358 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 260799010359 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 260799010360 Walker A/P-loop; other site 260799010361 ATP binding site [chemical binding]; other site 260799010362 Q-loop/lid; other site 260799010363 ABC transporter signature motif; other site 260799010364 Walker B; other site 260799010365 D-loop; other site 260799010366 H-loop/switch region; other site 260799010367 putative acyltransferase; Provisional; Region: PRK05790 260799010368 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 260799010369 dimer interface [polypeptide binding]; other site 260799010370 active site 260799010371 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 260799010372 nudix motif; other site 260799010373 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 260799010374 hypothetical protein; Validated; Region: PRK07668 260799010375 hypothetical protein; Validated; Region: PRK07668 260799010376 hypothetical protein; Validated; Region: PRK07668 260799010377 Predicted transcriptional regulators [Transcription]; Region: COG1695 260799010378 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 260799010379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 260799010380 NAD(P) binding site [chemical binding]; other site 260799010381 active site 260799010382 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 260799010383 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 260799010384 Phosphotransferase enzyme family; Region: APH; pfam01636 260799010385 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 260799010386 putative active site [active] 260799010387 catalytic triad [active] 260799010388 putative dimer interface [polypeptide binding]; other site 260799010389 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 260799010390 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 260799010391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799010392 homodimer interface [polypeptide binding]; other site 260799010393 catalytic residue [active] 260799010394 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 260799010395 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 260799010396 dimer interface [polypeptide binding]; other site 260799010397 active site 260799010398 catalytic residue [active] 260799010399 metal binding site [ion binding]; metal-binding site 260799010400 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 260799010401 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 260799010402 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 260799010403 intersubunit interface [polypeptide binding]; other site 260799010404 active site 260799010405 Zn2+ binding site [ion binding]; other site 260799010406 Cupin domain; Region: Cupin_2; cl17218 260799010407 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 260799010408 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 260799010409 metal binding site [ion binding]; metal-binding site 260799010410 active site 260799010411 I-site; other site 260799010412 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 260799010413 dimer interface [polypeptide binding]; other site 260799010414 FMN binding site [chemical binding]; other site 260799010415 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 260799010416 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 260799010417 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 260799010418 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 260799010419 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 260799010420 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 260799010421 dimerization domain swap beta strand [polypeptide binding]; other site 260799010422 regulatory protein interface [polypeptide binding]; other site 260799010423 active site 260799010424 regulatory phosphorylation site [posttranslational modification]; other site 260799010425 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 260799010426 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 260799010427 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 260799010428 active site turn [active] 260799010429 phosphorylation site [posttranslational modification] 260799010430 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 260799010431 HPr interaction site; other site 260799010432 glycerol kinase (GK) interaction site [polypeptide binding]; other site 260799010433 active site 260799010434 phosphorylation site [posttranslational modification] 260799010435 transcriptional antiterminator BglG; Provisional; Region: PRK09772 260799010436 CAT RNA binding domain; Region: CAT_RBD; smart01061 260799010437 PRD domain; Region: PRD; pfam00874 260799010438 PRD domain; Region: PRD; pfam00874 260799010439 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 260799010440 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799010441 active site 260799010442 motif I; other site 260799010443 motif II; other site 260799010444 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799010445 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 260799010446 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 260799010447 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 260799010448 DNA-binding site [nucleotide binding]; DNA binding site 260799010449 UTRA domain; Region: UTRA; pfam07702 260799010450 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 260799010451 active site 260799010452 trimer interface [polypeptide binding]; other site 260799010453 allosteric site; other site 260799010454 active site lid [active] 260799010455 hexamer (dimer of trimers) interface [polypeptide binding]; other site 260799010456 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 260799010457 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 260799010458 active site 260799010459 dimer interface [polypeptide binding]; other site 260799010460 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 260799010461 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 260799010462 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 260799010463 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 260799010464 Domain of unknown function (DUF309); Region: DUF309; pfam03745 260799010465 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799010466 Coenzyme A binding pocket [chemical binding]; other site 260799010467 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 260799010468 active site 260799010469 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 260799010470 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 260799010471 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799010472 active site 260799010473 motif I; other site 260799010474 motif II; other site 260799010475 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 260799010476 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 260799010477 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 260799010478 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 260799010479 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 260799010480 stage V sporulation protein AD; Validated; Region: PRK08304 260799010481 stage V sporulation protein AD; Region: spore_V_AD; TIGR02845 260799010482 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 260799010483 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 260799010484 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 260799010485 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 260799010486 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 260799010487 Na2 binding site [ion binding]; other site 260799010488 putative substrate binding site 1 [chemical binding]; other site 260799010489 Na binding site 1 [ion binding]; other site 260799010490 putative substrate binding site 2 [chemical binding]; other site 260799010491 sporulation sigma factor SigF; Validated; Region: PRK05572 260799010492 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799010493 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 260799010494 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 260799010495 DNA binding residues [nucleotide binding] 260799010496 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799010497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799010498 ATP binding site [chemical binding]; other site 260799010499 Mg2+ binding site [ion binding]; other site 260799010500 G-X-G motif; other site 260799010501 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 260799010502 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 260799010503 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 260799010504 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 260799010505 Predicted transcriptional regulators [Transcription]; Region: COG1725 260799010506 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 260799010507 DNA-binding site [nucleotide binding]; DNA binding site 260799010508 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 260799010509 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 260799010510 Walker A/P-loop; other site 260799010511 ATP binding site [chemical binding]; other site 260799010512 Q-loop/lid; other site 260799010513 ABC transporter signature motif; other site 260799010514 Walker B; other site 260799010515 D-loop; other site 260799010516 H-loop/switch region; other site 260799010517 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 260799010518 Transcriptional regulators [Transcription]; Region: MarR; COG1846 260799010519 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 260799010520 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 260799010521 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 260799010522 Sulfate transporter family; Region: Sulfate_transp; cl19250 260799010523 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 260799010524 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 260799010525 oligomer interface [polypeptide binding]; other site 260799010526 metal binding site [ion binding]; metal-binding site 260799010527 metal binding site [ion binding]; metal-binding site 260799010528 putative Cl binding site [ion binding]; other site 260799010529 aspartate ring; other site 260799010530 basic sphincter; other site 260799010531 hydrophobic gate; other site 260799010532 periplasmic entrance; other site 260799010533 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 260799010534 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 260799010535 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 260799010536 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 260799010537 purine nucleoside phosphorylase; Provisional; Region: PRK08202 260799010538 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 260799010539 phosphopentomutase; Provisional; Region: PRK05362 260799010540 YtkA-like; Region: YtkA; pfam13115 260799010541 YtkA-like; Region: YtkA; pfam13115 260799010542 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 260799010543 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 260799010544 active site 260799010545 Int/Topo IB signature motif; other site 260799010546 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 260799010547 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 260799010548 metal binding site 2 [ion binding]; metal-binding site 260799010549 putative DNA binding helix; other site 260799010550 metal binding site 1 [ion binding]; metal-binding site 260799010551 dimer interface [polypeptide binding]; other site 260799010552 structural Zn2+ binding site [ion binding]; other site 260799010553 stage II sporulation protein M; Region: spo_II_M; TIGR02831 260799010554 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799010555 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 260799010556 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 260799010557 dimer interface [polypeptide binding]; other site 260799010558 ADP-ribose binding site [chemical binding]; other site 260799010559 active site 260799010560 nudix motif; other site 260799010561 metal binding site [ion binding]; metal-binding site 260799010562 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 260799010563 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 260799010564 active site 260799010565 catalytic tetrad [active] 260799010566 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 260799010567 active site 260799010568 catalytic tetrad [active] 260799010569 GrpB protein; Region: GrpB; pfam04229 260799010570 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 260799010571 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 260799010572 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 260799010573 putative active site [active] 260799010574 putative metal binding site [ion binding]; other site 260799010575 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 260799010576 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 260799010577 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 260799010578 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799010579 Predicted permease [General function prediction only]; Region: COG2056 260799010580 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 260799010581 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 260799010582 Transcriptional regulators [Transcription]; Region: PurR; COG1609 260799010583 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 260799010584 DNA binding site [nucleotide binding] 260799010585 domain linker motif; other site 260799010586 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 260799010587 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 260799010588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799010589 Coenzyme A binding pocket [chemical binding]; other site 260799010590 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 260799010591 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799010592 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 260799010593 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 260799010594 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 260799010595 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 260799010596 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 260799010597 catalytic motif [active] 260799010598 Zn binding site [ion binding]; other site 260799010599 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 260799010600 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 260799010601 Lumazine binding domain; Region: Lum_binding; pfam00677 260799010602 Lumazine binding domain; Region: Lum_binding; pfam00677 260799010603 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 260799010604 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 260799010605 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 260799010606 dimerization interface [polypeptide binding]; other site 260799010607 active site 260799010608 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 260799010609 homopentamer interface [polypeptide binding]; other site 260799010610 active site 260799010611 biotin synthase; Validated; Region: PRK06256 260799010612 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 260799010613 FeS/SAM binding site; other site 260799010614 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 260799010615 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 260799010616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799010617 S-adenosylmethionine binding site [chemical binding]; other site 260799010618 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 260799010619 Protein of unknown function (DUF452); Region: DUF452; cl01062 260799010620 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799010621 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 260799010622 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 260799010623 substrate-cofactor binding pocket; other site 260799010624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799010625 catalytic residue [active] 260799010626 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 260799010627 AAA domain; Region: AAA_26; pfam13500 260799010628 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 260799010629 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 260799010630 inhibitor-cofactor binding pocket; inhibition site 260799010631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799010632 catalytic residue [active] 260799010633 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 260799010634 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 260799010635 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 260799010636 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 260799010637 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 260799010638 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 260799010639 active site 260799010640 metal binding site [ion binding]; metal-binding site 260799010641 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 260799010642 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 260799010643 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 260799010644 active site 260799010645 catalytic triad [active] 260799010646 oxyanion hole [active] 260799010647 Transcriptional regulators [Transcription]; Region: MarR; COG1846 260799010648 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799010649 dimerization interface [polypeptide binding]; other site 260799010650 putative DNA binding site [nucleotide binding]; other site 260799010651 putative Zn2+ binding site [ion binding]; other site 260799010652 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 260799010653 ornithine carbamoyltransferase; Provisional; Region: PRK00779 260799010654 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 260799010655 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 260799010656 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 260799010657 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 260799010658 inhibitor-cofactor binding pocket; inhibition site 260799010659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799010660 catalytic residue [active] 260799010661 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 260799010662 nucleotide binding site [chemical binding]; other site 260799010663 N-acetyl-L-glutamate binding site [chemical binding]; other site 260799010664 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 260799010665 heterotetramer interface [polypeptide binding]; other site 260799010666 active site pocket [active] 260799010667 cleavage site 260799010668 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 260799010669 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 260799010670 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 260799010671 YqzH-like protein; Region: YqzH; pfam14164 260799010672 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 260799010673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 260799010674 NAD(P) binding site [chemical binding]; other site 260799010675 active site 260799010676 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 260799010677 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 260799010678 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 260799010679 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 260799010680 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 260799010681 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 260799010682 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 260799010683 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 260799010684 putative L-serine binding site [chemical binding]; other site 260799010685 ribonuclease Z; Region: RNase_Z; TIGR02651 260799010686 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 260799010687 DNA polymerase IV; Validated; Region: PRK01810 260799010688 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 260799010689 active site 260799010690 DNA binding site [nucleotide binding] 260799010691 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 260799010692 peptidase T-like protein; Region: PepT-like; TIGR01883 260799010693 metal binding site [ion binding]; metal-binding site 260799010694 putative dimer interface [polypeptide binding]; other site 260799010695 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 260799010696 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 260799010697 Protein of unknown function (DUF3894); Region: DUF3894; pfam13033 260799010698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 260799010699 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 260799010700 Predicted membrane protein [Function unknown]; Region: COG4129 260799010701 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 260799010702 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 260799010703 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 260799010704 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 260799010705 Walker A/P-loop; other site 260799010706 ATP binding site [chemical binding]; other site 260799010707 Q-loop/lid; other site 260799010708 ABC transporter signature motif; other site 260799010709 Walker B; other site 260799010710 D-loop; other site 260799010711 H-loop/switch region; other site 260799010712 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 260799010713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799010714 dimer interface [polypeptide binding]; other site 260799010715 conserved gate region; other site 260799010716 putative PBP binding loops; other site 260799010717 ABC-ATPase subunit interface; other site 260799010718 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 260799010719 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 260799010720 substrate binding pocket [chemical binding]; other site 260799010721 membrane-bound complex binding site; other site 260799010722 hinge residues; other site 260799010723 Disulphide isomerase; Region: Disulph_isomer; pfam06491 260799010724 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 260799010725 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 260799010726 nudix motif; other site 260799010727 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 260799010728 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 260799010729 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 260799010730 E3 interaction surface; other site 260799010731 lipoyl attachment site [posttranslational modification]; other site 260799010732 e3 binding domain; Region: E3_binding; pfam02817 260799010733 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 260799010734 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 260799010735 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 260799010736 alpha subunit interface [polypeptide binding]; other site 260799010737 TPP binding site [chemical binding]; other site 260799010738 heterodimer interface [polypeptide binding]; other site 260799010739 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 260799010740 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 260799010741 tetramer interface [polypeptide binding]; other site 260799010742 TPP-binding site [chemical binding]; other site 260799010743 heterodimer interface [polypeptide binding]; other site 260799010744 phosphorylation loop region [posttranslational modification] 260799010745 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 260799010746 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 260799010747 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 260799010748 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 260799010749 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 260799010750 nucleotide binding site [chemical binding]; other site 260799010751 Acetokinase family; Region: Acetate_kinase; cl17229 260799010752 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 260799010753 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 260799010754 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 260799010755 NAD binding site [chemical binding]; other site 260799010756 Phe binding site; other site 260799010757 phosphate butyryltransferase; Validated; Region: PRK07742 260799010758 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 260799010759 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 260799010760 putative active site [active] 260799010761 heme pocket [chemical binding]; other site 260799010762 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 260799010763 putative active site [active] 260799010764 heme pocket [chemical binding]; other site 260799010765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799010766 Walker A motif; other site 260799010767 ATP binding site [chemical binding]; other site 260799010768 Walker B motif; other site 260799010769 arginine finger; other site 260799010770 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 260799010771 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 260799010772 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 260799010773 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 260799010774 active site 260799010775 catalytic site [active] 260799010776 metal binding site [ion binding]; metal-binding site 260799010777 dimer interface [polypeptide binding]; other site 260799010778 conserved hypothetical integral membrane protein; Region: TIGR03766 260799010779 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 260799010780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799010781 active site 260799010782 phosphorylation site [posttranslational modification] 260799010783 intermolecular recognition site; other site 260799010784 dimerization interface [polypeptide binding]; other site 260799010785 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 260799010786 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 260799010787 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 260799010788 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 260799010789 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 260799010790 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 260799010791 Walker A/P-loop; other site 260799010792 ATP binding site [chemical binding]; other site 260799010793 Q-loop/lid; other site 260799010794 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 260799010795 ABC transporter signature motif; other site 260799010796 Walker B; other site 260799010797 D-loop; other site 260799010798 H-loop/switch region; other site 260799010799 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 260799010800 arginine repressor; Provisional; Region: PRK04280 260799010801 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 260799010802 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 260799010803 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 260799010804 RNA binding surface [nucleotide binding]; other site 260799010805 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 260799010806 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 260799010807 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 260799010808 TPP-binding site; other site 260799010809 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 260799010810 PYR/PP interface [polypeptide binding]; other site 260799010811 dimer interface [polypeptide binding]; other site 260799010812 TPP binding site [chemical binding]; other site 260799010813 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 260799010814 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 260799010815 substrate binding pocket [chemical binding]; other site 260799010816 chain length determination region; other site 260799010817 active site lid residues [active] 260799010818 substrate-Mg2+ binding site; other site 260799010819 catalytic residues [active] 260799010820 aspartate-rich region 1; other site 260799010821 aspartate-rich region 2; other site 260799010822 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 260799010823 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 260799010824 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 260799010825 generic binding surface II; other site 260799010826 generic binding surface I; other site 260799010827 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 260799010828 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 260799010829 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 260799010830 homodimer interface [polypeptide binding]; other site 260799010831 NADP binding site [chemical binding]; other site 260799010832 substrate binding site [chemical binding]; other site 260799010833 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 260799010834 putative RNA binding site [nucleotide binding]; other site 260799010835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 260799010836 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 260799010837 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 260799010838 ATP-grasp domain; Region: ATP-grasp_4; cl17255 260799010839 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 260799010840 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 260799010841 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 260799010842 carboxyltransferase (CT) interaction site; other site 260799010843 biotinylation site [posttranslational modification]; other site 260799010844 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 260799010845 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 260799010846 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 260799010847 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 260799010848 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 260799010849 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 260799010850 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 260799010851 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 260799010852 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799010853 Walker A motif; other site 260799010854 ATP binding site [chemical binding]; other site 260799010855 Walker B motif; other site 260799010856 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 260799010857 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799010858 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 260799010859 elongation factor P; Validated; Region: PRK00529 260799010860 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 260799010861 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 260799010862 RNA binding site [nucleotide binding]; other site 260799010863 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 260799010864 RNA binding site [nucleotide binding]; other site 260799010865 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 260799010866 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 260799010867 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 260799010868 active site 260799010869 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 260799010870 trimer interface [polypeptide binding]; other site 260799010871 active site 260799010872 dimer interface [polypeptide binding]; other site 260799010873 Conserved membrane protein YqhR; Region: YqhR; pfam11085 260799010874 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 260799010875 CCC1-related family of proteins; Region: CCC1_like; cl00278 260799010876 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 260799010877 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 260799010878 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799010879 motif II; other site 260799010880 manganese transport transcriptional regulator; Provisional; Region: PRK03902 260799010881 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 260799010882 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 260799010883 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 260799010884 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 260799010885 FeS/SAM binding site; other site 260799010886 ribonuclease E; Reviewed; Region: rne; PRK10811 260799010887 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 260799010888 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 260799010889 active site residue [active] 260799010890 Transcriptional regulators [Transcription]; Region: PurR; COG1609 260799010891 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 260799010892 DNA binding site [nucleotide binding] 260799010893 domain linker motif; other site 260799010894 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 260799010895 putative dimerization interface [polypeptide binding]; other site 260799010896 putative ligand binding site [chemical binding]; other site 260799010897 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799010898 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799010899 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 260799010900 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 260799010901 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 260799010902 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 260799010903 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 260799010904 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 260799010905 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 260799010906 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 260799010907 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 260799010908 Walker A/P-loop; other site 260799010909 ATP binding site [chemical binding]; other site 260799010910 Q-loop/lid; other site 260799010911 ABC transporter signature motif; other site 260799010912 Walker B; other site 260799010913 D-loop; other site 260799010914 H-loop/switch region; other site 260799010915 Predicted transcriptional regulators [Transcription]; Region: COG1725 260799010916 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 260799010917 DNA-binding site [nucleotide binding]; DNA binding site 260799010918 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 260799010919 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 260799010920 tetramer interface [polypeptide binding]; other site 260799010921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799010922 catalytic residue [active] 260799010923 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 260799010924 tetramer interface [polypeptide binding]; other site 260799010925 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799010926 catalytic residue [active] 260799010927 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 260799010928 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 260799010929 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 260799010930 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 260799010931 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 260799010932 ATP binding site [chemical binding]; other site 260799010933 putative Mg++ binding site [ion binding]; other site 260799010934 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 260799010935 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 260799010936 nucleotide binding region [chemical binding]; other site 260799010937 ATP-binding site [chemical binding]; other site 260799010938 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 260799010939 YqzE-like protein; Region: YqzE; pfam14038 260799010940 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 260799010941 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 260799010942 ADP binding site [chemical binding]; other site 260799010943 magnesium binding site [ion binding]; other site 260799010944 putative shikimate binding site; other site 260799010945 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 260799010946 dihydroorotase; Provisional; Region: PRK04250 260799010947 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 260799010948 Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine; Region: Bromodomain; cl02556 260799010949 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 260799010950 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 260799010951 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 260799010952 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 260799010953 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 260799010954 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 260799010955 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 260799010956 Walker A motif; other site 260799010957 ATP binding site [chemical binding]; other site 260799010958 Walker B motif; other site 260799010959 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799010960 putative DNA binding site [nucleotide binding]; other site 260799010961 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 260799010962 putative Zn2+ binding site [ion binding]; other site 260799010963 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 260799010964 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 260799010965 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 260799010966 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 260799010967 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 260799010968 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 260799010969 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 260799010970 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 260799010971 active site 260799010972 homodimer interface [polypeptide binding]; other site 260799010973 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 260799010974 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 260799010975 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 260799010976 substrate binding pocket [chemical binding]; other site 260799010977 dimer interface [polypeptide binding]; other site 260799010978 inhibitor binding site; inhibition site 260799010979 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 260799010980 B12 binding site [chemical binding]; other site 260799010981 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 260799010982 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 260799010983 Homocysteine S-methyltransferase; Region: S-methyl_trans; cl14105 260799010984 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 260799010985 FAD binding site [chemical binding]; other site 260799010986 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 260799010987 homodimer interface [polypeptide binding]; other site 260799010988 substrate-cofactor binding pocket; other site 260799010989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799010990 catalytic residue [active] 260799010991 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 260799010992 homodimer interface [polypeptide binding]; other site 260799010993 substrate-cofactor binding pocket; other site 260799010994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799010995 catalytic residue [active] 260799010996 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 260799010997 catalytic triad [active] 260799010998 conserved cis-peptide bond; other site 260799010999 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799011000 dimerization interface [polypeptide binding]; other site 260799011001 putative DNA binding site [nucleotide binding]; other site 260799011002 putative Zn2+ binding site [ion binding]; other site 260799011003 Uncharacterized conserved protein [Function unknown]; Region: COG1565 260799011004 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 260799011005 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 260799011006 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 260799011007 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 260799011008 nucleotide binding site [chemical binding]; other site 260799011009 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 260799011010 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 260799011011 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 260799011012 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 260799011013 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 260799011014 active site 260799011015 Substrate binding site; other site 260799011016 Mg++ binding site; other site 260799011017 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 260799011018 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 260799011019 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 260799011020 active site 260799011021 metal binding site [ion binding]; metal-binding site 260799011022 substrate binding site [chemical binding]; other site 260799011023 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 260799011024 PhoU domain; Region: PhoU; pfam01895 260799011025 PhoU domain; Region: PhoU; pfam01895 260799011026 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 260799011027 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 260799011028 Walker A/P-loop; other site 260799011029 ATP binding site [chemical binding]; other site 260799011030 Q-loop/lid; other site 260799011031 ABC transporter signature motif; other site 260799011032 Walker B; other site 260799011033 D-loop; other site 260799011034 H-loop/switch region; other site 260799011035 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 260799011036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799011037 dimer interface [polypeptide binding]; other site 260799011038 conserved gate region; other site 260799011039 putative PBP binding loops; other site 260799011040 ABC-ATPase subunit interface; other site 260799011041 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 260799011042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799011043 dimer interface [polypeptide binding]; other site 260799011044 conserved gate region; other site 260799011045 putative PBP binding loops; other site 260799011046 ABC-ATPase subunit interface; other site 260799011047 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 260799011048 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 260799011049 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 260799011050 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 260799011051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799011052 putative substrate translocation pore; other site 260799011053 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799011054 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 260799011055 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 260799011056 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 260799011057 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 260799011058 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 260799011059 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 260799011060 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 260799011061 metal binding site 2 [ion binding]; metal-binding site 260799011062 putative DNA binding helix; other site 260799011063 metal binding site 1 [ion binding]; metal-binding site 260799011064 dimer interface [polypeptide binding]; other site 260799011065 structural Zn2+ binding site [ion binding]; other site 260799011066 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 260799011067 ABC-ATPase subunit interface; other site 260799011068 dimer interface [polypeptide binding]; other site 260799011069 putative PBP binding regions; other site 260799011070 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 260799011071 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 260799011072 Uncharacterized conserved protein [Function unknown]; Region: COG1284 260799011073 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 260799011074 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 260799011075 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 260799011076 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 260799011077 AP (apurinic/apyrimidinic) site pocket; other site 260799011078 DNA interaction; other site 260799011079 Metal-binding active site; metal-binding site 260799011080 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 260799011081 DEAD-like helicases superfamily; Region: DEXDc; smart00487 260799011082 ATP binding site [chemical binding]; other site 260799011083 Mg++ binding site [ion binding]; other site 260799011084 motif III; other site 260799011085 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 260799011086 nucleotide binding region [chemical binding]; other site 260799011087 ATP-binding site [chemical binding]; other site 260799011088 YqfQ-like protein; Region: YqfQ; pfam14181 260799011089 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 260799011090 Fe-S cluster binding site [ion binding]; other site 260799011091 substrate binding site [chemical binding]; other site 260799011092 catalytic site [active] 260799011093 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 260799011094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 260799011095 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 260799011096 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 260799011097 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 260799011098 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 260799011099 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 260799011100 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 260799011101 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799011102 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 260799011103 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 260799011104 DNA binding residues [nucleotide binding] 260799011105 DNA primase; Validated; Region: dnaG; PRK05667 260799011106 CHC2 zinc finger; Region: zf-CHC2; pfam01807 260799011107 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 260799011108 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 260799011109 active site 260799011110 metal binding site [ion binding]; metal-binding site 260799011111 interdomain interaction site; other site 260799011112 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 260799011113 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 260799011114 PEP synthetase regulatory protein; Provisional; Region: PRK05339 260799011115 HTH domain; Region: HTH_11; pfam08279 260799011116 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 260799011117 FOG: CBS domain [General function prediction only]; Region: COG0517 260799011118 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 260799011119 Recombination protein O N terminal; Region: RecO_N; pfam11967 260799011120 Recombination protein O C terminal; Region: RecO_C; pfam02565 260799011121 GTPase Era; Reviewed; Region: era; PRK00089 260799011122 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 260799011123 G1 box; other site 260799011124 GTP/Mg2+ binding site [chemical binding]; other site 260799011125 Switch I region; other site 260799011126 G2 box; other site 260799011127 Switch II region; other site 260799011128 G3 box; other site 260799011129 G4 box; other site 260799011130 G5 box; other site 260799011131 KH domain; Region: KH_2; pfam07650 260799011132 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 260799011133 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 260799011134 active site 260799011135 catalytic motif [active] 260799011136 Zn binding site [ion binding]; other site 260799011137 Integral membrane undecaprenol kinase and similar enzymes; Region: UDPK_IM_like; cd14265 260799011138 trimer interface [polypeptide binding]; other site 260799011139 putative active site [active] 260799011140 Zn binding site [ion binding]; other site 260799011141 metal-binding heat shock protein; Provisional; Region: PRK00016 260799011142 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 260799011143 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 260799011144 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 260799011145 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 260799011146 Zn2+ binding site [ion binding]; other site 260799011147 Mg2+ binding site [ion binding]; other site 260799011148 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 260799011149 PhoH-like protein; Region: PhoH; pfam02562 260799011150 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 260799011151 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 260799011152 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 260799011153 Yqey-like protein; Region: YqeY; pfam09424 260799011154 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 260799011155 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 260799011156 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 260799011157 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 260799011158 FeS/SAM binding site; other site 260799011159 TRAM domain; Region: TRAM; cl01282 260799011160 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 260799011161 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 260799011162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799011163 S-adenosylmethionine binding site [chemical binding]; other site 260799011164 chaperone protein DnaJ; Provisional; Region: PRK14280 260799011165 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 260799011166 HSP70 interaction site [polypeptide binding]; other site 260799011167 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 260799011168 substrate binding site [polypeptide binding]; other site 260799011169 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 260799011170 Zn binding sites [ion binding]; other site 260799011171 dimer interface [polypeptide binding]; other site 260799011172 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 260799011173 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 260799011174 nucleotide binding site [chemical binding]; other site 260799011175 NEF interaction site [polypeptide binding]; other site 260799011176 SBD interface [polypeptide binding]; other site 260799011177 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 260799011178 dimer interface [polypeptide binding]; other site 260799011179 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 260799011180 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 260799011181 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 260799011182 HrcA protein C terminal domain; Region: HrcA; pfam01628 260799011183 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 260799011184 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 260799011185 FeS/SAM binding site; other site 260799011186 HemN C-terminal domain; Region: HemN_C; pfam06969 260799011187 Predicted transcriptional regulators [Transcription]; Region: COG1733 260799011188 dimerization interface [polypeptide binding]; other site 260799011189 putative DNA binding site [nucleotide binding]; other site 260799011190 putative Zn2+ binding site [ion binding]; other site 260799011191 GTP-binding protein LepA; Provisional; Region: PRK05433 260799011192 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 260799011193 G1 box; other site 260799011194 putative GEF interaction site [polypeptide binding]; other site 260799011195 GTP/Mg2+ binding site [chemical binding]; other site 260799011196 Switch I region; other site 260799011197 G2 box; other site 260799011198 G3 box; other site 260799011199 Switch II region; other site 260799011200 G4 box; other site 260799011201 G5 box; other site 260799011202 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 260799011203 Elongation Factor G, domain II; Region: EFG_II; pfam14492 260799011204 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 260799011205 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 260799011206 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 260799011207 germination protease; Provisional; Region: PRK02858 260799011208 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 260799011209 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 260799011210 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 260799011211 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 260799011212 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 260799011213 Competence protein; Region: Competence; pfam03772 260799011214 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 260799011215 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 260799011216 catalytic motif [active] 260799011217 Zn binding site [ion binding]; other site 260799011218 SLBB domain; Region: SLBB; pfam10531 260799011219 comEA protein; Region: comE; TIGR01259 260799011220 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 260799011221 late competence protein ComER; Validated; Region: PRK07680 260799011222 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 260799011223 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 260799011224 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 260799011225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799011226 S-adenosylmethionine binding site [chemical binding]; other site 260799011227 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889 260799011228 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 260799011229 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 260799011230 Zn2+ binding site [ion binding]; other site 260799011231 Mg2+ binding site [ion binding]; other site 260799011232 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 260799011233 active site 260799011234 (T/H)XGH motif; other site 260799011235 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 260799011236 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 260799011237 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 260799011238 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 260799011239 shikimate binding site; other site 260799011240 NAD(P) binding site [chemical binding]; other site 260799011241 GTPase YqeH; Provisional; Region: PRK13796 260799011242 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 260799011243 GTP/Mg2+ binding site [chemical binding]; other site 260799011244 G4 box; other site 260799011245 G5 box; other site 260799011246 G1 box; other site 260799011247 Switch I region; other site 260799011248 G2 box; other site 260799011249 G3 box; other site 260799011250 Switch II region; other site 260799011251 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799011252 active site 260799011253 motif I; other site 260799011254 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 260799011255 motif II; other site 260799011256 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 260799011257 sporulation sigma factor SigK; Reviewed; Region: PRK05803 260799011258 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799011259 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 260799011260 DNA binding residues [nucleotide binding] 260799011261 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 260799011262 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 260799011263 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 260799011264 dimer interface [polypeptide binding]; other site 260799011265 FMN binding site [chemical binding]; other site 260799011266 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 260799011267 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 260799011268 synthetase active site [active] 260799011269 NTP binding site [chemical binding]; other site 260799011270 metal binding site [ion binding]; metal-binding site 260799011271 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 260799011272 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 260799011273 dimer interface [polypeptide binding]; other site 260799011274 active site 260799011275 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799011276 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 260799011277 Coenzyme A binding pocket [chemical binding]; other site 260799011278 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 260799011279 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799011280 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 260799011281 Predicted membrane protein [Function unknown]; Region: COG2259 260799011282 CHAT domain; Region: CHAT; cl19248 260799011283 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 260799011284 catalytic core [active] 260799011285 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 260799011286 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 260799011287 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 260799011288 Subtilase family; Region: Peptidase_S8; pfam00082 260799011289 catalytic triad [active] 260799011290 putative active site [active] 260799011291 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 260799011292 PA/protease or protease-like domain interface [polypeptide binding]; other site 260799011293 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 260799011294 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 260799011295 cofactor binding site; other site 260799011296 metal binding site [ion binding]; metal-binding site 260799011297 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 260799011298 aromatic arch; other site 260799011299 DCoH dimer interaction site [polypeptide binding]; other site 260799011300 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 260799011301 DCoH tetramer interaction site [polypeptide binding]; other site 260799011302 substrate binding site [chemical binding]; other site 260799011303 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 260799011304 active site 260799011305 metal binding site [ion binding]; metal-binding site 260799011306 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 260799011307 putative metal binding site [ion binding]; other site 260799011308 Predicted membrane protein [Function unknown]; Region: COG2259 260799011309 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 260799011310 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799011311 non-specific DNA binding site [nucleotide binding]; other site 260799011312 salt bridge; other site 260799011313 sequence-specific DNA binding site [nucleotide binding]; other site 260799011314 Cupin domain; Region: Cupin_2; pfam07883 260799011315 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 260799011316 dimer interaction site [polypeptide binding]; other site 260799011317 substrate-binding tunnel; other site 260799011318 active site 260799011319 catalytic site [active] 260799011320 substrate binding site [chemical binding]; other site 260799011321 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799011322 Coenzyme A binding pocket [chemical binding]; other site 260799011323 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 260799011324 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799011325 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 260799011326 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 260799011327 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 260799011328 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 260799011329 Walker A/P-loop; other site 260799011330 ATP binding site [chemical binding]; other site 260799011331 Q-loop/lid; other site 260799011332 ABC transporter signature motif; other site 260799011333 Walker B; other site 260799011334 D-loop; other site 260799011335 H-loop/switch region; other site 260799011336 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 260799011337 ABC-ATPase subunit interface; other site 260799011338 dimer interface [polypeptide binding]; other site 260799011339 putative PBP binding regions; other site 260799011340 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 260799011341 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 260799011342 intersubunit interface [polypeptide binding]; other site 260799011343 YrhC-like protein; Region: YrhC; pfam14143 260799011344 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 260799011345 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 260799011346 putative catalytic cysteine [active] 260799011347 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 260799011348 putative active site [active] 260799011349 metal binding site [ion binding]; metal-binding site 260799011350 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 260799011351 homodimer interface [polypeptide binding]; other site 260799011352 substrate-cofactor binding pocket; other site 260799011353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799011354 catalytic residue [active] 260799011355 cysteine synthase; Region: PLN02565 260799011356 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 260799011357 dimer interface [polypeptide binding]; other site 260799011358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799011359 catalytic residue [active] 260799011360 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 260799011361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799011362 S-adenosylmethionine binding site [chemical binding]; other site 260799011363 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 260799011364 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 260799011365 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 260799011366 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 260799011367 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 260799011368 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 260799011369 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 260799011370 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 260799011371 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 260799011372 ATP-binding site [chemical binding]; other site 260799011373 Sugar specificity; other site 260799011374 Pyrimidine base specificity; other site 260799011375 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 260799011376 putative protease; Provisional; Region: PRK15452 260799011377 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 260799011378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799011379 S-adenosylmethionine binding site [chemical binding]; other site 260799011380 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 260799011381 dimerization interface [polypeptide binding]; other site 260799011382 hypothetical protein; Provisional; Region: PRK13678 260799011383 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 260799011384 hypothetical protein; Provisional; Region: PRK05473 260799011385 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 260799011386 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 260799011387 motif 1; other site 260799011388 active site 260799011389 motif 2; other site 260799011390 motif 3; other site 260799011391 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 260799011392 DHHA1 domain; Region: DHHA1; pfam02272 260799011393 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 260799011394 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 260799011395 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 260799011396 AAA domain; Region: AAA_30; pfam13604 260799011397 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 260799011398 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799011399 TPR motif; other site 260799011400 TPR repeat; Region: TPR_11; pfam13414 260799011401 binding surface 260799011402 TPR repeat; Region: TPR_11; pfam13414 260799011403 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799011404 binding surface 260799011405 TPR motif; other site 260799011406 TPR repeat; Region: TPR_11; pfam13414 260799011407 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 260799011408 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 260799011409 Ligand Binding Site [chemical binding]; other site 260799011410 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 260799011411 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 260799011412 catalytic residue [active] 260799011413 Predicted transcriptional regulator [Transcription]; Region: COG1959 260799011414 Rrf2 family protein; Region: rrf2_super; TIGR00738 260799011415 recombination factor protein RarA; Reviewed; Region: PRK13342 260799011416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799011417 Walker A motif; other site 260799011418 ATP binding site [chemical binding]; other site 260799011419 Walker B motif; other site 260799011420 arginine finger; other site 260799011421 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 260799011422 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 260799011423 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 260799011424 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 260799011425 putative ATP binding site [chemical binding]; other site 260799011426 putative substrate interface [chemical binding]; other site 260799011427 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 260799011428 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 260799011429 dimer interface [polypeptide binding]; other site 260799011430 anticodon binding site; other site 260799011431 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 260799011432 homodimer interface [polypeptide binding]; other site 260799011433 motif 1; other site 260799011434 active site 260799011435 motif 2; other site 260799011436 GAD domain; Region: GAD; pfam02938 260799011437 motif 3; other site 260799011438 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 260799011439 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 260799011440 dimer interface [polypeptide binding]; other site 260799011441 motif 1; other site 260799011442 active site 260799011443 motif 2; other site 260799011444 motif 3; other site 260799011445 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 260799011446 anticodon binding site; other site 260799011447 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 260799011448 putative active site [active] 260799011449 dimerization interface [polypeptide binding]; other site 260799011450 putative tRNAtyr binding site [nucleotide binding]; other site 260799011451 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 260799011452 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 260799011453 Zn2+ binding site [ion binding]; other site 260799011454 Mg2+ binding site [ion binding]; other site 260799011455 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 260799011456 synthetase active site [active] 260799011457 NTP binding site [chemical binding]; other site 260799011458 metal binding site [ion binding]; metal-binding site 260799011459 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 260799011460 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 260799011461 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 260799011462 active site 260799011463 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 260799011464 DHH family; Region: DHH; pfam01368 260799011465 DHHA1 domain; Region: DHHA1; pfam02272 260799011466 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 260799011467 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 260799011468 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 260799011469 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 260799011470 MMPL family; Region: MMPL; cl14618 260799011471 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 260799011472 Protein export membrane protein; Region: SecD_SecF; pfam02355 260799011473 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 260799011474 stage V sporulation protein B; Region: spore_V_B; TIGR02900 260799011475 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 260799011476 Predicted membrane protein [Function unknown]; Region: COG2323 260799011477 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 260799011478 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 260799011479 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 260799011480 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 260799011481 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 260799011482 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 260799011483 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 260799011484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799011485 Walker A motif; other site 260799011486 ATP binding site [chemical binding]; other site 260799011487 Walker B motif; other site 260799011488 arginine finger; other site 260799011489 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 260799011490 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 260799011491 RuvA N terminal domain; Region: RuvA_N; pfam01330 260799011492 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 260799011493 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 260799011494 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 260799011495 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 260799011496 putative ligand binding residues [chemical binding]; other site 260799011497 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 260799011498 BofC C-terminal domain; Region: BofC_C; pfam08955 260799011499 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799011500 dimerization interface [polypeptide binding]; other site 260799011501 putative DNA binding site [nucleotide binding]; other site 260799011502 putative Zn2+ binding site [ion binding]; other site 260799011503 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 260799011504 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 260799011505 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 260799011506 quinolinate synthetase; Provisional; Region: PRK09375 260799011507 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 260799011508 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 260799011509 dimerization interface [polypeptide binding]; other site 260799011510 active site 260799011511 L-aspartate oxidase; Provisional; Region: PRK08071 260799011512 L-aspartate oxidase; Provisional; Region: PRK06175 260799011513 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 260799011514 cysteine desulfurase; Provisional; Region: PRK02948 260799011515 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 260799011516 catalytic residue [active] 260799011517 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 260799011518 HTH domain; Region: HTH_11; pfam08279 260799011519 3H domain; Region: 3H; pfam02829 260799011520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 260799011521 MOSC domain; Region: MOSC; pfam03473 260799011522 3-alpha domain; Region: 3-alpha; pfam03475 260799011523 prephenate dehydratase; Provisional; Region: PRK11898 260799011524 Prephenate dehydratase; Region: PDT; pfam00800 260799011525 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 260799011526 putative L-Phe binding site [chemical binding]; other site 260799011527 FtsX-like permease family; Region: FtsX; pfam02687 260799011528 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 260799011529 FtsX-like permease family; Region: FtsX; pfam02687 260799011530 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 260799011531 FtsX-like permease family; Region: FtsX; pfam02687 260799011532 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 260799011533 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 260799011534 Walker A/P-loop; other site 260799011535 ATP binding site [chemical binding]; other site 260799011536 Q-loop/lid; other site 260799011537 ABC transporter signature motif; other site 260799011538 Walker B; other site 260799011539 D-loop; other site 260799011540 H-loop/switch region; other site 260799011541 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799011542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799011543 active site 260799011544 phosphorylation site [posttranslational modification] 260799011545 intermolecular recognition site; other site 260799011546 dimerization interface [polypeptide binding]; other site 260799011547 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799011548 DNA binding site [nucleotide binding] 260799011549 GTPase CgtA; Reviewed; Region: obgE; PRK12297 260799011550 GTP1/OBG; Region: GTP1_OBG; pfam01018 260799011551 Obg GTPase; Region: Obg; cd01898 260799011552 G1 box; other site 260799011553 GTP/Mg2+ binding site [chemical binding]; other site 260799011554 Switch I region; other site 260799011555 G2 box; other site 260799011556 G3 box; other site 260799011557 Switch II region; other site 260799011558 G4 box; other site 260799011559 G5 box; other site 260799011560 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 260799011561 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 260799011562 Sporulation initiation phospho-transferase B, C-terminal; Region: SPOB_ab; pfam14682 260799011563 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 260799011564 hypothetical protein; Provisional; Region: PRK14553 260799011565 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 260799011566 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 260799011567 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 260799011568 homodimer interface [polypeptide binding]; other site 260799011569 oligonucleotide binding site [chemical binding]; other site 260799011570 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 260799011571 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 260799011572 Peptidase family M50; Region: Peptidase_M50; pfam02163 260799011573 active site 260799011574 putative substrate binding region [chemical binding]; other site 260799011575 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 260799011576 Peptidase family M23; Region: Peptidase_M23; pfam01551 260799011577 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 260799011578 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 260799011579 P-loop; other site 260799011580 ADP binding residues [chemical binding]; other site 260799011581 Switch I; other site 260799011582 Switch II; other site 260799011583 septum formation inhibitor; Reviewed; Region: minC; PRK00513 260799011584 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 260799011585 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 260799011586 rod shape-determining protein MreC; Provisional; Region: PRK13922 260799011587 rod shape-determining protein MreB; Provisional; Region: PRK13927 260799011588 MreB and similar proteins; Region: MreB_like; cd10225 260799011589 nucleotide binding site [chemical binding]; other site 260799011590 Mg binding site [ion binding]; other site 260799011591 putative protofilament interaction site [polypeptide binding]; other site 260799011592 RodZ interaction site [polypeptide binding]; other site 260799011593 hypothetical protein; Reviewed; Region: PRK00024 260799011594 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 260799011595 MPN+ (JAMM) motif; other site 260799011596 Zinc-binding site [ion binding]; other site 260799011597 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 260799011598 active site 260799011599 dimer interface [polypeptide binding]; other site 260799011600 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 260799011601 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 260799011602 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 260799011603 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 260799011604 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 260799011605 active site 260799011606 HIGH motif; other site 260799011607 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 260799011608 KMSKS motif; other site 260799011609 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 260799011610 tRNA binding surface [nucleotide binding]; other site 260799011611 anticodon binding site; other site 260799011612 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 260799011613 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 260799011614 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 260799011615 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 260799011616 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 260799011617 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 260799011618 inhibitor-cofactor binding pocket; inhibition site 260799011619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799011620 catalytic residue [active] 260799011621 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 260799011622 dimer interface [polypeptide binding]; other site 260799011623 active site 260799011624 Schiff base residues; other site 260799011625 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 260799011626 active site 260799011627 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 260799011628 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 260799011629 domain interfaces; other site 260799011630 active site 260799011631 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 260799011632 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 260799011633 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 260799011634 tRNA; other site 260799011635 putative tRNA binding site [nucleotide binding]; other site 260799011636 putative NADP binding site [chemical binding]; other site 260799011637 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 260799011638 Transcriptional regulators [Transcription]; Region: MarR; COG1846 260799011639 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 260799011640 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 260799011641 Predicted GTPase [General function prediction only]; Region: COG0218 260799011642 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 260799011643 G1 box; other site 260799011644 GTP/Mg2+ binding site [chemical binding]; other site 260799011645 Switch I region; other site 260799011646 G2 box; other site 260799011647 G3 box; other site 260799011648 Switch II region; other site 260799011649 G4 box; other site 260799011650 G5 box; other site 260799011651 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 260799011652 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 260799011653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799011654 Walker A motif; other site 260799011655 ATP binding site [chemical binding]; other site 260799011656 Walker B motif; other site 260799011657 arginine finger; other site 260799011658 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 260799011659 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 260799011660 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799011661 Walker A motif; other site 260799011662 ATP binding site [chemical binding]; other site 260799011663 Walker B motif; other site 260799011664 arginine finger; other site 260799011665 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 260799011666 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 260799011667 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 260799011668 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799011669 Walker A motif; other site 260799011670 ATP binding site [chemical binding]; other site 260799011671 Walker B motif; other site 260799011672 arginine finger; other site 260799011673 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 260799011674 trigger factor; Provisional; Region: tig; PRK01490 260799011675 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 260799011676 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 260799011677 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 260799011678 Bacterial PH domain; Region: bPH_1; pfam08000 260799011679 YvbH-like oligomerization region; Region: YvbH_ext; pfam11724 260799011680 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 260799011681 active site 260799011682 metal binding site [ion binding]; metal-binding site 260799011683 homotetramer interface [polypeptide binding]; other site 260799011684 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 260799011685 active site 260799011686 dimerization interface [polypeptide binding]; other site 260799011687 ribonuclease PH; Reviewed; Region: rph; PRK00173 260799011688 Ribonuclease PH; Region: RNase_PH_bact; cd11362 260799011689 hexamer interface [polypeptide binding]; other site 260799011690 active site 260799011691 Sporulation and spore germination; Region: Germane; pfam10646 260799011692 Spore germination protein [General function prediction only]; Region: COG5401 260799011693 Sporulation and spore germination; Region: Germane; pfam10646 260799011694 glutamate racemase; Provisional; Region: PRK00865 260799011695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799011696 putative substrate translocation pore; other site 260799011697 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 260799011698 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 260799011699 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 260799011700 potential catalytic triad [active] 260799011701 conserved cys residue [active] 260799011702 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799011703 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799011704 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 260799011705 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 260799011706 potential catalytic triad [active] 260799011707 conserved cys residue [active] 260799011708 Gar1/Naf1 RNA binding region; Region: Gar1; cl01285 260799011709 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 260799011710 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 260799011711 DNA binding residues [nucleotide binding] 260799011712 dimerization interface [polypeptide binding]; other site 260799011713 Sulfate transporter family; Region: Sulfate_transp; cl19250 260799011714 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 260799011715 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 260799011716 EamA-like transporter family; Region: EamA; pfam00892 260799011717 EamA-like transporter family; Region: EamA; pfam00892 260799011718 cytosine deaminase; Provisional; Region: PRK05985 260799011719 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 260799011720 active site 260799011721 cytosine deaminase; Provisional; Region: PRK05985 260799011722 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 260799011723 active site 260799011724 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 260799011725 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 260799011726 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 260799011727 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 260799011728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799011729 dimer interface [polypeptide binding]; other site 260799011730 conserved gate region; other site 260799011731 putative PBP binding loops; other site 260799011732 ABC-ATPase subunit interface; other site 260799011733 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 260799011734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799011735 dimer interface [polypeptide binding]; other site 260799011736 conserved gate region; other site 260799011737 putative PBP binding loops; other site 260799011738 ABC-ATPase subunit interface; other site 260799011739 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 260799011740 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 260799011741 Walker A/P-loop; other site 260799011742 ATP binding site [chemical binding]; other site 260799011743 Q-loop/lid; other site 260799011744 ABC transporter signature motif; other site 260799011745 Walker B; other site 260799011746 D-loop; other site 260799011747 H-loop/switch region; other site 260799011748 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 260799011749 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 260799011750 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 260799011751 Walker A/P-loop; other site 260799011752 ATP binding site [chemical binding]; other site 260799011753 Q-loop/lid; other site 260799011754 ABC transporter signature motif; other site 260799011755 Walker B; other site 260799011756 D-loop; other site 260799011757 H-loop/switch region; other site 260799011758 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 260799011759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799011760 active site 260799011761 phosphorylation site [posttranslational modification] 260799011762 intermolecular recognition site; other site 260799011763 dimerization interface [polypeptide binding]; other site 260799011764 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 260799011765 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 260799011766 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 260799011767 PspC domain; Region: PspC; pfam04024 260799011768 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 260799011769 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799011770 non-specific DNA binding site [nucleotide binding]; other site 260799011771 salt bridge; other site 260799011772 sequence-specific DNA binding site [nucleotide binding]; other site 260799011773 Cupin domain; Region: Cupin_2; pfam07883 260799011774 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 260799011775 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 260799011776 amphipathic channel; other site 260799011777 Asn-Pro-Ala signature motifs; other site 260799011778 Predicted transcriptional regulator [Transcription]; Region: COG1959 260799011779 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 260799011780 Acyltransferase family; Region: Acyl_transf_3; cl19154 260799011781 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 260799011782 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 260799011783 Walker A/P-loop; other site 260799011784 ATP binding site [chemical binding]; other site 260799011785 Q-loop/lid; other site 260799011786 ABC transporter signature motif; other site 260799011787 Walker B; other site 260799011788 D-loop; other site 260799011789 H-loop/switch region; other site 260799011790 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 260799011791 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 260799011792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799011793 active site 260799011794 motif I; other site 260799011795 motif II; other site 260799011796 flagellar motor protein MotA; Validated; Region: PRK08124 260799011797 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 260799011798 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 260799011799 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 260799011800 active site 260799011801 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 260799011802 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 260799011803 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 260799011804 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 260799011805 L-aspartate oxidase; Provisional; Region: PRK06175 260799011806 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 260799011807 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 260799011808 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 260799011809 putative Iron-sulfur protein interface [polypeptide binding]; other site 260799011810 proximal heme binding site [chemical binding]; other site 260799011811 distal heme binding site [chemical binding]; other site 260799011812 putative dimer interface [polypeptide binding]; other site 260799011813 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 260799011814 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 260799011815 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 260799011816 GIY-YIG motif/motif A; other site 260799011817 active site 260799011818 catalytic site [active] 260799011819 putative DNA binding site [nucleotide binding]; other site 260799011820 metal binding site [ion binding]; metal-binding site 260799011821 Cytochrome P450; Region: p450; cl12078 260799011822 UvrB/uvrC motif; Region: UVR; pfam02151 260799011823 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 260799011824 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 260799011825 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 260799011826 catalytic residues [active] 260799011827 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 260799011828 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 260799011829 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 260799011830 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 260799011831 Ligand binding site [chemical binding]; other site 260799011832 enoyl-CoA hydratase; Provisional; Region: PRK07658 260799011833 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 260799011834 substrate binding site [chemical binding]; other site 260799011835 oxyanion hole (OAH) forming residues; other site 260799011836 trimer interface [polypeptide binding]; other site 260799011837 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799011838 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799011839 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 260799011840 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 260799011841 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 260799011842 acyl-activating enzyme (AAE) consensus motif; other site 260799011843 putative AMP binding site [chemical binding]; other site 260799011844 putative active site [active] 260799011845 putative CoA binding site [chemical binding]; other site 260799011846 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 260799011847 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 260799011848 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 260799011849 siderophore binding site; other site 260799011850 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 260799011851 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 260799011852 ABC-ATPase subunit interface; other site 260799011853 dimer interface [polypeptide binding]; other site 260799011854 putative PBP binding regions; other site 260799011855 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 260799011856 ABC-ATPase subunit interface; other site 260799011857 dimer interface [polypeptide binding]; other site 260799011858 putative PBP binding regions; other site 260799011859 DinB family; Region: DinB; cl17821 260799011860 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 260799011861 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 260799011862 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 260799011863 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 260799011864 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 260799011865 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 260799011866 Walker A/P-loop; other site 260799011867 ATP binding site [chemical binding]; other site 260799011868 Q-loop/lid; other site 260799011869 ABC transporter signature motif; other site 260799011870 Walker B; other site 260799011871 D-loop; other site 260799011872 H-loop/switch region; other site 260799011873 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799011874 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799011875 dimer interface [polypeptide binding]; other site 260799011876 phosphorylation site [posttranslational modification] 260799011877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799011878 ATP binding site [chemical binding]; other site 260799011879 Mg2+ binding site [ion binding]; other site 260799011880 G-X-G motif; other site 260799011881 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799011882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799011883 active site 260799011884 phosphorylation site [posttranslational modification] 260799011885 intermolecular recognition site; other site 260799011886 dimerization interface [polypeptide binding]; other site 260799011887 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799011888 DNA binding site [nucleotide binding] 260799011889 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 260799011890 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 260799011891 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 260799011892 putative RNA binding site [nucleotide binding]; other site 260799011893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 260799011894 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 260799011895 TrkA-N domain; Region: TrkA_N; pfam02254 260799011896 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 260799011897 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 260799011898 active site 260799011899 catalytic site [active] 260799011900 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 260799011901 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 260799011902 Walker A/P-loop; other site 260799011903 ATP binding site [chemical binding]; other site 260799011904 Q-loop/lid; other site 260799011905 ABC transporter signature motif; other site 260799011906 Walker B; other site 260799011907 D-loop; other site 260799011908 H-loop/switch region; other site 260799011909 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 260799011910 ABC-ATPase subunit interface; other site 260799011911 dimer interface [polypeptide binding]; other site 260799011912 putative PBP binding regions; other site 260799011913 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 260799011914 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 260799011915 intersubunit interface [polypeptide binding]; other site 260799011916 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 260799011917 heme-binding site [chemical binding]; other site 260799011918 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 260799011919 heme-binding site [chemical binding]; other site 260799011920 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 260799011921 heme-binding site [chemical binding]; other site 260799011922 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 260799011923 heme-binding site [chemical binding]; other site 260799011924 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 260799011925 heme-binding site [chemical binding]; other site 260799011926 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 260799011927 heme-binding site [chemical binding]; other site 260799011928 heme uptake protein IsdC; Region: IsdC; TIGR03656 260799011929 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 260799011930 heme-binding site [chemical binding]; other site 260799011931 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 260799011932 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 260799011933 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 260799011934 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 260799011935 RNA binding surface [nucleotide binding]; other site 260799011936 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 260799011937 probable active site [active] 260799011938 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 260799011939 MutS domain III; Region: MutS_III; pfam05192 260799011940 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 260799011941 Walker A/P-loop; other site 260799011942 ATP binding site [chemical binding]; other site 260799011943 Q-loop/lid; other site 260799011944 ABC transporter signature motif; other site 260799011945 Walker B; other site 260799011946 D-loop; other site 260799011947 H-loop/switch region; other site 260799011948 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 260799011949 Smr domain; Region: Smr; pfam01713 260799011950 hypothetical protein; Provisional; Region: PRK08609 260799011951 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 260799011952 active site 260799011953 primer binding site [nucleotide binding]; other site 260799011954 NTP binding site [chemical binding]; other site 260799011955 metal binding triad [ion binding]; metal-binding site 260799011956 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 260799011957 active site 260799011958 Colicin V production protein; Region: Colicin_V; pfam02674 260799011959 cell division protein ZapA; Provisional; Region: PRK14126 260799011960 ribonuclease HIII; Provisional; Region: PRK00996 260799011961 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 260799011962 Bacterial type 2 ribonuclease, HII and HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 260799011963 RNA/DNA hybrid binding site [nucleotide binding]; other site 260799011964 active site 260799011965 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 260799011966 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 260799011967 putative dimer interface [polypeptide binding]; other site 260799011968 putative anticodon binding site; other site 260799011969 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 260799011970 homodimer interface [polypeptide binding]; other site 260799011971 motif 1; other site 260799011972 motif 2; other site 260799011973 active site 260799011974 motif 3; other site 260799011975 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 260799011976 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 260799011977 putative tRNA-binding site [nucleotide binding]; other site 260799011978 B3/4 domain; Region: B3_4; pfam03483 260799011979 tRNA synthetase B5 domain; Region: B5; smart00874 260799011980 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 260799011981 dimer interface [polypeptide binding]; other site 260799011982 motif 1; other site 260799011983 motif 3; other site 260799011984 motif 2; other site 260799011985 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 260799011986 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 260799011987 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 260799011988 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 260799011989 dimer interface [polypeptide binding]; other site 260799011990 motif 1; other site 260799011991 active site 260799011992 motif 2; other site 260799011993 motif 3; other site 260799011994 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 260799011995 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 260799011996 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 260799011997 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 260799011998 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 260799011999 Zn2+ binding site [ion binding]; other site 260799012000 Mg2+ binding site [ion binding]; other site 260799012001 CAAX protease self-immunity; Region: Abi; pfam02517 260799012002 CAAX protease self-immunity; Region: Abi; pfam02517 260799012003 ComEC family competence protein; Provisional; Region: PRK11539 260799012004 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 260799012005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799012006 putative substrate translocation pore; other site 260799012007 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 260799012008 HlyD family secretion protein; Region: HlyD_3; pfam13437 260799012009 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799012010 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799012011 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 260799012012 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 260799012013 oligomer interface [polypeptide binding]; other site 260799012014 active site 260799012015 metal binding site [ion binding]; metal-binding site 260799012016 dUTPase; Region: dUTPase_2; pfam08761 260799012017 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 260799012018 active site 260799012019 homodimer interface [polypeptide binding]; other site 260799012020 metal binding site [ion binding]; metal-binding site 260799012021 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 260799012022 23S rRNA binding site [nucleotide binding]; other site 260799012023 L21 binding site [polypeptide binding]; other site 260799012024 L13 binding site [polypeptide binding]; other site 260799012025 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 260799012026 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 260799012027 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 260799012028 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 260799012029 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 260799012030 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 260799012031 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 260799012032 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 260799012033 active site 260799012034 dimer interface [polypeptide binding]; other site 260799012035 motif 1; other site 260799012036 motif 2; other site 260799012037 motif 3; other site 260799012038 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 260799012039 anticodon binding site; other site 260799012040 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 260799012041 primosomal protein DnaI; Reviewed; Region: PRK08939 260799012042 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 260799012043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 260799012044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799012045 Walker A motif; other site 260799012046 ATP binding site [chemical binding]; other site 260799012047 Walker B motif; other site 260799012048 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 260799012049 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 260799012050 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 260799012051 ATP cone domain; Region: ATP-cone; pfam03477 260799012052 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 260799012053 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 260799012054 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 260799012055 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 260799012056 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 260799012057 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 260799012058 CoA-binding site [chemical binding]; other site 260799012059 ATP-binding [chemical binding]; other site 260799012060 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 260799012061 Domain of unknown function DUF; Region: DUF204; pfam02659 260799012062 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 260799012063 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 260799012064 DNA binding site [nucleotide binding] 260799012065 catalytic residue [active] 260799012066 H2TH interface [polypeptide binding]; other site 260799012067 putative catalytic residues [active] 260799012068 turnover-facilitating residue; other site 260799012069 intercalation triad [nucleotide binding]; other site 260799012070 8OG recognition residue [nucleotide binding]; other site 260799012071 putative reading head residues; other site 260799012072 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 260799012073 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 260799012074 DNA polymerase I; Provisional; Region: PRK05755 260799012075 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 260799012076 active site 260799012077 metal binding site 1 [ion binding]; metal-binding site 260799012078 putative 5' ssDNA interaction site; other site 260799012079 metal binding site 3; metal-binding site 260799012080 metal binding site 2 [ion binding]; metal-binding site 260799012081 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 260799012082 putative DNA binding site [nucleotide binding]; other site 260799012083 putative metal binding site [ion binding]; other site 260799012084 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 260799012085 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 260799012086 active site 260799012087 DNA binding site [nucleotide binding] 260799012088 catalytic site [active] 260799012089 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 260799012090 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799012091 dimerization interface [polypeptide binding]; other site 260799012092 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 260799012093 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 260799012094 putative active site [active] 260799012095 heme pocket [chemical binding]; other site 260799012096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799012097 dimer interface [polypeptide binding]; other site 260799012098 phosphorylation site [posttranslational modification] 260799012099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799012100 ATP binding site [chemical binding]; other site 260799012101 Mg2+ binding site [ion binding]; other site 260799012102 G-X-G motif; other site 260799012103 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799012104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799012105 active site 260799012106 phosphorylation site [posttranslational modification] 260799012107 intermolecular recognition site; other site 260799012108 dimerization interface [polypeptide binding]; other site 260799012109 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799012110 DNA binding site [nucleotide binding] 260799012111 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 260799012112 active site 2 [active] 260799012113 active site 1 [active] 260799012114 malate dehydrogenase; Reviewed; Region: PRK06223 260799012115 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 260799012116 NAD(P) binding site [chemical binding]; other site 260799012117 dimer interface [polypeptide binding]; other site 260799012118 tetramer (dimer of dimers) interface [polypeptide binding]; other site 260799012119 substrate binding site [chemical binding]; other site 260799012120 isocitrate dehydrogenase; Reviewed; Region: PRK07006 260799012121 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 260799012122 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 260799012123 dimer interface [polypeptide binding]; other site 260799012124 active site 260799012125 citrylCoA binding site [chemical binding]; other site 260799012126 oxalacetate/citrate binding site [chemical binding]; other site 260799012127 coenzyme A binding site [chemical binding]; other site 260799012128 catalytic triad [active] 260799012129 Protein of unknown function (DUF441); Region: DUF441; pfam04284 260799012130 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 260799012131 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 260799012132 pyruvate kinase; Provisional; Region: PRK06354 260799012133 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 260799012134 domain interfaces; other site 260799012135 active site 260799012136 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 260799012137 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 260799012138 active site 260799012139 ADP/pyrophosphate binding site [chemical binding]; other site 260799012140 dimerization interface [polypeptide binding]; other site 260799012141 allosteric effector site; other site 260799012142 fructose-1,6-bisphosphate binding site; other site 260799012143 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 260799012144 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 260799012145 Transcriptional regulators [Transcription]; Region: FadR; COG2186 260799012146 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 260799012147 DNA-binding site [nucleotide binding]; DNA binding site 260799012148 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 260799012149 Malic enzyme, N-terminal domain; Region: malic; pfam00390 260799012150 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 260799012151 putative NAD(P) binding site [chemical binding]; other site 260799012152 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 260799012153 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 260799012154 active site 260799012155 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 260799012156 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 260799012157 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 260799012158 generic binding surface II; other site 260799012159 generic binding surface I; other site 260799012160 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 260799012161 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 260799012162 DHH family; Region: DHH; pfam01368 260799012163 DHHA1 domain; Region: DHHA1; pfam02272 260799012164 YtpI-like protein; Region: YtpI; pfam14007 260799012165 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 260799012166 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 260799012167 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 260799012168 DNA-binding site [nucleotide binding]; DNA binding site 260799012169 DRTGG domain; Region: DRTGG; pfam07085 260799012170 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 260799012171 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 260799012172 active site 2 [active] 260799012173 active site 1 [active] 260799012174 metal-dependent hydrolase; Provisional; Region: PRK00685 260799012175 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 260799012176 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 260799012177 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 260799012178 active site 260799012179 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 260799012180 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 260799012181 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 260799012182 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799012183 Coenzyme A binding pocket [chemical binding]; other site 260799012184 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 260799012185 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799012186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799012187 Coenzyme A binding pocket [chemical binding]; other site 260799012188 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 260799012189 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 260799012190 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799012191 non-specific DNA binding site [nucleotide binding]; other site 260799012192 salt bridge; other site 260799012193 sequence-specific DNA binding site [nucleotide binding]; other site 260799012194 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 260799012195 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 260799012196 hexamer interface [polypeptide binding]; other site 260799012197 ligand binding site [chemical binding]; other site 260799012198 putative active site [active] 260799012199 NAD(P) binding site [chemical binding]; other site 260799012200 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 260799012201 classical (c) SDRs; Region: SDR_c; cd05233 260799012202 NAD(P) binding site [chemical binding]; other site 260799012203 active site 260799012204 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 260799012205 Ligand Binding Site [chemical binding]; other site 260799012206 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 260799012207 argininosuccinate lyase; Provisional; Region: PRK00855 260799012208 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 260799012209 active sites [active] 260799012210 tetramer interface [polypeptide binding]; other site 260799012211 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 260799012212 ANP binding site [chemical binding]; other site 260799012213 Substrate Binding Site II [chemical binding]; other site 260799012214 Substrate Binding Site I [chemical binding]; other site 260799012215 Uncharacterized conserved protein [Function unknown]; Region: COG1284 260799012216 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 260799012217 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 260799012218 EcsC protein family; Region: EcsC; pfam12787 260799012219 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 260799012220 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 260799012221 nudix motif; other site 260799012222 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 260799012223 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 260799012224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799012225 S-adenosylmethionine binding site [chemical binding]; other site 260799012226 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 260799012227 dimer interface [polypeptide binding]; other site 260799012228 catalytic triad [active] 260799012229 peroxidatic and resolving cysteines [active] 260799012230 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 260799012231 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 260799012232 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 260799012233 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 260799012234 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 260799012235 active site 260799012236 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 260799012237 dimer interface [polypeptide binding]; other site 260799012238 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 260799012239 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 260799012240 acyl-activating enzyme (AAE) consensus motif; other site 260799012241 AMP binding site [chemical binding]; other site 260799012242 active site 260799012243 CoA binding site [chemical binding]; other site 260799012244 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 260799012245 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 260799012246 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 260799012247 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 260799012248 Ligand Binding Site [chemical binding]; other site 260799012249 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 260799012250 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 260799012251 catalytic residue [active] 260799012252 septation ring formation regulator EzrA; Provisional; Region: PRK04778 260799012253 Transcriptional regulator [Transcription]; Region: LysR; COG0583 260799012254 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 260799012255 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 260799012256 dimerization interface [polypeptide binding]; other site 260799012257 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 260799012258 EamA-like transporter family; Region: EamA; pfam00892 260799012259 EamA-like transporter family; Region: EamA; pfam00892 260799012260 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 260799012261 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 260799012262 homodimer interface [polypeptide binding]; other site 260799012263 substrate-cofactor binding pocket; other site 260799012264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799012265 catalytic residue [active] 260799012266 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 260799012267 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 260799012268 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 260799012269 RNA binding surface [nucleotide binding]; other site 260799012270 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 260799012271 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 260799012272 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 260799012273 active site 260799012274 HIGH motif; other site 260799012275 dimer interface [polypeptide binding]; other site 260799012276 KMSKS motif; other site 260799012277 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 260799012278 RNA binding surface [nucleotide binding]; other site 260799012279 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 260799012280 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799012281 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 260799012282 DNA binding residues [nucleotide binding] 260799012283 acetyl-CoA synthetase; Provisional; Region: PRK04319 260799012284 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 260799012285 acyl-activating enzyme (AAE) consensus motif; other site 260799012286 AMP binding site [chemical binding]; other site 260799012287 active site 260799012288 CoA binding site [chemical binding]; other site 260799012289 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799012290 Coenzyme A binding pocket [chemical binding]; other site 260799012291 FOG: CBS domain [General function prediction only]; Region: COG0517 260799012292 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 260799012293 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 260799012294 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 260799012295 active site 260799012296 Zn binding site [ion binding]; other site 260799012297 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799012298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799012299 active site 260799012300 phosphorylation site [posttranslational modification] 260799012301 intermolecular recognition site; other site 260799012302 dimerization interface [polypeptide binding]; other site 260799012303 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799012304 DNA binding site [nucleotide binding] 260799012305 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799012306 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799012307 dimerization interface [polypeptide binding]; other site 260799012308 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799012309 dimer interface [polypeptide binding]; other site 260799012310 phosphorylation site [posttranslational modification] 260799012311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799012312 ATP binding site [chemical binding]; other site 260799012313 Mg2+ binding site [ion binding]; other site 260799012314 G-X-G motif; other site 260799012315 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 260799012316 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 260799012317 Ankyrin repeat; Region: Ank; pfam00023 260799012318 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 260799012319 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 260799012320 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 260799012321 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 260799012322 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 260799012323 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 260799012324 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 260799012325 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 260799012326 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 260799012327 catabolite control protein A; Region: ccpA; TIGR01481 260799012328 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 260799012329 DNA binding site [nucleotide binding] 260799012330 domain linker motif; other site 260799012331 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 260799012332 dimerization interface [polypeptide binding]; other site 260799012333 effector binding site; other site 260799012334 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 260799012335 putative dimer interface [polypeptide binding]; other site 260799012336 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 260799012337 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 260799012338 putative dimer interface [polypeptide binding]; other site 260799012339 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 260799012340 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 260799012341 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 260799012342 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 260799012343 Flavin Reductases; Region: FlaRed; cl00801 260799012344 Bacterial PH domain; Region: bPH_4; pfam06713 260799012345 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 260799012346 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799012347 Coenzyme A binding pocket [chemical binding]; other site 260799012348 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 260799012349 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 260799012350 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 260799012351 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 260799012352 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 260799012353 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 260799012354 active site 260799012355 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 260799012356 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 260799012357 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 260799012358 Domain of unknown function (DUF4479); Region: DUF4479; pfam14794 260799012359 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 260799012360 putative tRNA-binding site [nucleotide binding]; other site 260799012361 hypothetical protein; Provisional; Region: PRK13668 260799012362 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 260799012363 catalytic residues [active] 260799012364 NTPase; Reviewed; Region: PRK03114 260799012365 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 260799012366 oligomer interface [polypeptide binding]; other site 260799012367 active site 260799012368 metal binding site [ion binding]; metal-binding site 260799012369 Predicted small secreted protein [Function unknown]; Region: COG5584 260799012370 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 260799012371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799012372 S-adenosylmethionine binding site [chemical binding]; other site 260799012373 YtzH-like protein; Region: YtzH; pfam14165 260799012374 Phosphotransferase enzyme family; Region: APH; pfam01636 260799012375 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 260799012376 active site 260799012377 substrate binding site [chemical binding]; other site 260799012378 ATP binding site [chemical binding]; other site 260799012379 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 260799012380 pullulanase, type I; Region: pulA_typeI; TIGR02104 260799012381 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 260799012382 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 260799012383 Ca binding site [ion binding]; other site 260799012384 active site 260799012385 catalytic site [active] 260799012386 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 260799012387 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 260799012388 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 260799012389 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 260799012390 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 260799012391 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 260799012392 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 260799012393 active site 260799012394 uracil binding [chemical binding]; other site 260799012395 stage V sporulation protein B; Region: spore_V_B; TIGR02900 260799012396 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 260799012397 HI0933-like protein; Region: HI0933_like; pfam03486 260799012398 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 260799012399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799012400 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799012401 putative substrate translocation pore; other site 260799012402 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799012403 dimerization interface [polypeptide binding]; other site 260799012404 putative DNA binding site [nucleotide binding]; other site 260799012405 putative Zn2+ binding site [ion binding]; other site 260799012406 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 260799012407 putative hydrophobic ligand binding site [chemical binding]; other site 260799012408 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 260799012409 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 260799012410 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 260799012411 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 260799012412 glucose-1-dehydrogenase; Provisional; Region: PRK08936 260799012413 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 260799012414 NAD binding site [chemical binding]; other site 260799012415 homodimer interface [polypeptide binding]; other site 260799012416 active site 260799012417 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 260799012418 Sugar transport protein; Region: Sugar_transport; pfam06800 260799012419 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 260799012420 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 260799012421 MoaE interaction surface [polypeptide binding]; other site 260799012422 MoeB interaction surface [polypeptide binding]; other site 260799012423 thiocarboxylated glycine; other site 260799012424 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 260799012425 MoaE homodimer interface [polypeptide binding]; other site 260799012426 MoaD interaction [polypeptide binding]; other site 260799012427 active site residues [active] 260799012428 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 260799012429 Walker A motif; other site 260799012430 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 260799012431 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 260799012432 dimer interface [polypeptide binding]; other site 260799012433 putative functional site; other site 260799012434 putative MPT binding site; other site 260799012435 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 260799012436 trimer interface [polypeptide binding]; other site 260799012437 dimer interface [polypeptide binding]; other site 260799012438 putative active site [active] 260799012439 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 260799012440 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 260799012441 ATP binding site [chemical binding]; other site 260799012442 substrate interface [chemical binding]; other site 260799012443 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 260799012444 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 260799012445 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 260799012446 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 260799012447 active site residue [active] 260799012448 homoserine O-acetyltransferase; Provisional; Region: PRK06765 260799012449 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 260799012450 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 260799012451 Spore germination protein; Region: Spore_permease; pfam03845 260799012452 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 260799012453 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 260799012454 putative nucleotide binding site [chemical binding]; other site 260799012455 putative metal binding site [ion binding]; other site 260799012456 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 260799012457 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 260799012458 active site 260799012459 HIGH motif; other site 260799012460 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 260799012461 KMSKS motif; other site 260799012462 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 260799012463 tRNA binding surface [nucleotide binding]; other site 260799012464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799012465 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799012466 putative substrate translocation pore; other site 260799012467 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 260799012468 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 260799012469 TrkA-C domain; Region: TrkA_C; pfam02080 260799012470 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 260799012471 Int/Topo IB signature motif; other site 260799012472 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 260799012473 FtsX-like permease family; Region: FtsX; pfam02687 260799012474 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 260799012475 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 260799012476 Walker A/P-loop; other site 260799012477 ATP binding site [chemical binding]; other site 260799012478 Q-loop/lid; other site 260799012479 ABC transporter signature motif; other site 260799012480 Walker B; other site 260799012481 D-loop; other site 260799012482 H-loop/switch region; other site 260799012483 Predicted membrane protein [Function unknown]; Region: COG2311 260799012484 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 260799012485 Protein of unknown function (DUF418); Region: DUF418; pfam04235 260799012486 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 260799012487 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 260799012488 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 260799012489 FeS/SAM binding site; other site 260799012490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799012491 S-adenosylmethionine binding site [chemical binding]; other site 260799012492 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 260799012493 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 260799012494 Walker A/P-loop; other site 260799012495 ATP binding site [chemical binding]; other site 260799012496 Q-loop/lid; other site 260799012497 ABC transporter signature motif; other site 260799012498 Walker B; other site 260799012499 D-loop; other site 260799012500 H-loop/switch region; other site 260799012501 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 260799012502 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 260799012503 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 260799012504 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 260799012505 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 260799012506 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 260799012507 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 260799012508 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 260799012509 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 260799012510 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 260799012511 trimer interface [polypeptide binding]; other site 260799012512 putative metal binding site [ion binding]; other site 260799012513 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 260799012514 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 260799012515 active site 260799012516 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 260799012517 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 260799012518 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 260799012519 GTP binding site; other site 260799012520 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 260799012521 MPT binding site; other site 260799012522 trimer interface [polypeptide binding]; other site 260799012523 S-adenosylmethionine synthetase; Validated; Region: PRK05250 260799012524 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 260799012525 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 260799012526 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 260799012527 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 260799012528 active site 260799012529 substrate-binding site [chemical binding]; other site 260799012530 metal-binding site [ion binding] 260799012531 ATP binding site [chemical binding]; other site 260799012532 ATP synthase I chain; Region: ATP_synt_I; pfam03899 260799012533 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 260799012534 EamA-like transporter family; Region: EamA; pfam00892 260799012535 EamA-like transporter family; Region: EamA; pfam00892 260799012536 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; pfam01521 260799012537 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 260799012538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799012539 ATP binding site [chemical binding]; other site 260799012540 Mg2+ binding site [ion binding]; other site 260799012541 G-X-G motif; other site 260799012542 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799012543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799012544 dimer interface [polypeptide binding]; other site 260799012545 phosphorylation site [posttranslational modification] 260799012546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799012547 ATP binding site [chemical binding]; other site 260799012548 Mg2+ binding site [ion binding]; other site 260799012549 G-X-G motif; other site 260799012550 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 260799012551 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799012552 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799012553 Secretory lipase; Region: LIP; pfam03583 260799012554 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 260799012555 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 260799012556 NMT1-like family; Region: NMT1_2; pfam13379 260799012557 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 260799012558 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 260799012559 Walker A/P-loop; other site 260799012560 ATP binding site [chemical binding]; other site 260799012561 Q-loop/lid; other site 260799012562 ABC transporter signature motif; other site 260799012563 Walker B; other site 260799012564 D-loop; other site 260799012565 H-loop/switch region; other site 260799012566 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 260799012567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799012568 dimer interface [polypeptide binding]; other site 260799012569 conserved gate region; other site 260799012570 putative PBP binding loops; other site 260799012571 ABC-ATPase subunit interface; other site 260799012572 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 260799012573 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 260799012574 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 260799012575 nudix motif; other site 260799012576 tumor necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 260799012577 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 260799012578 S-ribosylhomocysteinase; Provisional; Region: PRK02260 260799012579 hypothetical protein; Validated; Region: PRK00041 260799012580 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 260799012581 active site clefts [active] 260799012582 zinc binding site [ion binding]; other site 260799012583 dimer interface [polypeptide binding]; other site 260799012584 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 260799012585 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 260799012586 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 260799012587 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 260799012588 S-layer homology domain; Region: SLH; pfam00395 260799012589 S-layer homology domain; Region: SLH; pfam00395 260799012590 S-layer homology domain; Region: SLH; pfam00395 260799012591 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 260799012592 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 260799012593 putative active site [active] 260799012594 Uncharacterized conserved protein [Function unknown]; Region: COG1284 260799012595 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 260799012596 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 260799012597 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 260799012598 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 260799012599 Predicted membrane protein [Function unknown]; Region: COG3766 260799012600 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 260799012601 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 260799012602 hypothetical protein; Provisional; Region: PRK12473 260799012603 Virus attachment protein p12 family; Region: P12; pfam12669 260799012604 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 260799012605 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 260799012606 G1 box; other site 260799012607 GTP/Mg2+ binding site [chemical binding]; other site 260799012608 Switch I region; other site 260799012609 G2 box; other site 260799012610 G3 box; other site 260799012611 Switch II region; other site 260799012612 G4 box; other site 260799012613 G5 box; other site 260799012614 Nucleoside recognition; Region: Gate; pfam07670 260799012615 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 260799012616 Nucleoside recognition; Region: Gate; pfam07670 260799012617 FeoA domain; Region: FeoA; pfam04023 260799012618 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 260799012619 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 260799012620 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799012621 dimerization interface [polypeptide binding]; other site 260799012622 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799012623 dimer interface [polypeptide binding]; other site 260799012624 phosphorylation site [posttranslational modification] 260799012625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799012626 ATP binding site [chemical binding]; other site 260799012627 Mg2+ binding site [ion binding]; other site 260799012628 G-X-G motif; other site 260799012629 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799012630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799012631 active site 260799012632 phosphorylation site [posttranslational modification] 260799012633 intermolecular recognition site; other site 260799012634 dimerization interface [polypeptide binding]; other site 260799012635 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799012636 DNA binding site [nucleotide binding] 260799012637 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 260799012638 active site 260799012639 catalytic site [active] 260799012640 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 260799012641 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 260799012642 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 260799012643 active site 260799012644 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 260799012645 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 260799012646 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 260799012647 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 260799012648 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 260799012649 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 260799012650 putative hydrophobic ligand binding site [chemical binding]; other site 260799012651 protein interface [polypeptide binding]; other site 260799012652 gate; other site 260799012653 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 260799012654 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 260799012655 active site 260799012656 catalytic tetrad [active] 260799012657 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 260799012658 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 260799012659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799012660 S-adenosylmethionine binding site [chemical binding]; other site 260799012661 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 260799012662 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 260799012663 FtsX-like permease family; Region: FtsX; pfam02687 260799012664 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 260799012665 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 260799012666 Walker A/P-loop; other site 260799012667 ATP binding site [chemical binding]; other site 260799012668 Q-loop/lid; other site 260799012669 ABC transporter signature motif; other site 260799012670 Walker B; other site 260799012671 D-loop; other site 260799012672 H-loop/switch region; other site 260799012673 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 260799012674 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 260799012675 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 260799012676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 260799012677 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799012678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799012679 active site 260799012680 phosphorylation site [posttranslational modification] 260799012681 intermolecular recognition site; other site 260799012682 dimerization interface [polypeptide binding]; other site 260799012683 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799012684 DNA binding site [nucleotide binding] 260799012685 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799012686 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 260799012687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799012688 ATP binding site [chemical binding]; other site 260799012689 Mg2+ binding site [ion binding]; other site 260799012690 G-X-G motif; other site 260799012691 FtsX-like permease family; Region: FtsX; pfam02687 260799012692 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 260799012693 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 260799012694 Walker A/P-loop; other site 260799012695 ATP binding site [chemical binding]; other site 260799012696 Q-loop/lid; other site 260799012697 ABC transporter signature motif; other site 260799012698 Walker B; other site 260799012699 D-loop; other site 260799012700 H-loop/switch region; other site 260799012701 GntP family permease; Region: GntP_permease; pfam02447 260799012702 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 260799012703 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 260799012704 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 260799012705 DNA-binding site [nucleotide binding]; DNA binding site 260799012706 UTRA domain; Region: UTRA; pfam07702 260799012707 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 260799012708 substrate binding site [chemical binding]; other site 260799012709 ATP binding site [chemical binding]; other site 260799012710 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 260799012711 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 260799012712 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 260799012713 catalytic residue [active] 260799012714 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 260799012715 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 260799012716 active site 260799012717 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 260799012718 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 260799012719 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 260799012720 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799012721 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799012722 dimerization interface [polypeptide binding]; other site 260799012723 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799012724 dimer interface [polypeptide binding]; other site 260799012725 phosphorylation site [posttranslational modification] 260799012726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799012727 ATP binding site [chemical binding]; other site 260799012728 Mg2+ binding site [ion binding]; other site 260799012729 G-X-G motif; other site 260799012730 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799012731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799012732 active site 260799012733 phosphorylation site [posttranslational modification] 260799012734 intermolecular recognition site; other site 260799012735 dimerization interface [polypeptide binding]; other site 260799012736 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799012737 DNA binding site [nucleotide binding] 260799012738 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 260799012739 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 260799012740 active site 260799012741 octamer interface [polypeptide binding]; other site 260799012742 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 260799012743 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 260799012744 acyl-activating enzyme (AAE) consensus motif; other site 260799012745 putative AMP binding site [chemical binding]; other site 260799012746 putative active site [active] 260799012747 putative CoA binding site [chemical binding]; other site 260799012748 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 260799012749 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 260799012750 substrate binding site [chemical binding]; other site 260799012751 oxyanion hole (OAH) forming residues; other site 260799012752 trimer interface [polypeptide binding]; other site 260799012753 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 260799012754 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799012755 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 260799012756 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 260799012757 dimer interface [polypeptide binding]; other site 260799012758 tetramer interface [polypeptide binding]; other site 260799012759 PYR/PP interface [polypeptide binding]; other site 260799012760 TPP binding site [chemical binding]; other site 260799012761 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 260799012762 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 260799012763 TPP-binding site; other site 260799012764 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 260799012765 chorismate binding enzyme; Region: Chorismate_bind; cl10555 260799012766 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 260799012767 putative active site [active] 260799012768 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 260799012769 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 260799012770 DNA-binding site [nucleotide binding]; DNA binding site 260799012771 RNA-binding motif; other site 260799012772 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 260799012773 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 260799012774 active site flap/lid [active] 260799012775 nucleophilic elbow; other site 260799012776 catalytic triad [active] 260799012777 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 260799012778 homodimer interface [polypeptide binding]; other site 260799012779 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 260799012780 active site pocket [active] 260799012781 glycogen synthase; Provisional; Region: glgA; PRK00654 260799012782 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 260799012783 ADP-binding pocket [chemical binding]; other site 260799012784 homodimer interface [polypeptide binding]; other site 260799012785 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 260799012786 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 260799012787 ligand binding site; other site 260799012788 oligomer interface; other site 260799012789 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 260799012790 dimer interface [polypeptide binding]; other site 260799012791 N-terminal domain interface [polypeptide binding]; other site 260799012792 sulfate 1 binding site; other site 260799012793 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 260799012794 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 260799012795 ligand binding site; other site 260799012796 oligomer interface; other site 260799012797 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 260799012798 dimer interface [polypeptide binding]; other site 260799012799 N-terminal domain interface [polypeptide binding]; other site 260799012800 sulfate 1 binding site; other site 260799012801 glycogen branching enzyme; Provisional; Region: PRK12313 260799012802 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 260799012803 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 260799012804 active site 260799012805 catalytic site [active] 260799012806 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 260799012807 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 260799012808 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 260799012809 tetramer (dimer of dimers) interface [polypeptide binding]; other site 260799012810 NAD binding site [chemical binding]; other site 260799012811 dimer interface [polypeptide binding]; other site 260799012812 substrate binding site [chemical binding]; other site 260799012813 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 260799012814 MgtC family; Region: MgtC; pfam02308 260799012815 Ion channel; Region: Ion_trans_2; pfam07885 260799012816 TrkA-N domain; Region: TrkA_N; pfam02254 260799012817 YugN-like family; Region: YugN; pfam08868 260799012818 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 260799012819 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 260799012820 active site 260799012821 dimer interface [polypeptide binding]; other site 260799012822 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 260799012823 dimer interface [polypeptide binding]; other site 260799012824 active site 260799012825 Domain of unknown function (DUF378); Region: DUF378; pfam04070 260799012826 general stress protein 13; Validated; Region: PRK08059 260799012827 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 260799012828 RNA binding site [nucleotide binding]; other site 260799012829 aspartate aminotransferase; Provisional; Region: PRK05764 260799012830 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 260799012831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799012832 homodimer interface [polypeptide binding]; other site 260799012833 catalytic residue [active] 260799012834 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 260799012835 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 260799012836 AsnC family; Region: AsnC_trans_reg; pfam01037 260799012837 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 260799012838 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 260799012839 dimerization interface [polypeptide binding]; other site 260799012840 ligand binding site [chemical binding]; other site 260799012841 NADP binding site [chemical binding]; other site 260799012842 catalytic site [active] 260799012843 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799012844 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 260799012845 Putative lysophospholipase; Region: Hydrolase_4; cl19140 260799012846 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 260799012847 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 260799012848 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 260799012849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799012850 homodimer interface [polypeptide binding]; other site 260799012851 catalytic residue [active] 260799012852 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 260799012853 E-class dimer interface [polypeptide binding]; other site 260799012854 P-class dimer interface [polypeptide binding]; other site 260799012855 active site 260799012856 Cu2+ binding site [ion binding]; other site 260799012857 Zn2+ binding site [ion binding]; other site 260799012858 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 260799012859 Kinase associated protein B; Region: KapB; pfam08810 260799012860 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 260799012861 active site 260799012862 catalytic site [active] 260799012863 substrate binding site [chemical binding]; other site 260799012864 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 260799012865 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 260799012866 transmembrane helices; other site 260799012867 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 260799012868 active site 260799012869 glycyl-tRNA synthetase; Provisional; Region: PRK04173 260799012870 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 260799012871 dimer interface [polypeptide binding]; other site 260799012872 motif 1; other site 260799012873 active site 260799012874 motif 2; other site 260799012875 motif 3; other site 260799012876 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 260799012877 anticodon binding site; other site 260799012878 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 260799012879 CoenzymeA binding site [chemical binding]; other site 260799012880 subunit interaction site [polypeptide binding]; other site 260799012881 PHB binding site; other site 260799012882 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 260799012883 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 260799012884 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 260799012885 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 260799012886 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 260799012887 active site 260799012888 tetramer interface; other site 260799012889 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 260799012890 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 260799012891 active site 260799012892 substrate binding site [chemical binding]; other site 260799012893 metal binding site [ion binding]; metal-binding site 260799012894 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 260799012895 Uncharacterized conserved protein [Function unknown]; Region: COG1624 260799012896 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 260799012897 multifunctional aminopeptidase A; Provisional; Region: PRK00913 260799012898 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 260799012899 interface (dimer of trimers) [polypeptide binding]; other site 260799012900 Substrate-binding/catalytic site; other site 260799012901 Zn-binding sites [ion binding]; other site 260799012902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 260799012903 Putative membrane protein; Region: YuiB; pfam14068 260799012904 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 260799012905 nudix motif; other site 260799012906 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 260799012907 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 260799012908 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 260799012909 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 260799012910 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 260799012911 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 260799012912 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 260799012913 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 260799012914 Domain of unknown function DUF11; Region: DUF11; pfam01345 260799012915 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 260799012916 Domain of unknown function DUF11; Region: DUF11; pfam01345 260799012917 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 260799012918 Domain of unknown function DUF11; Region: DUF11; pfam01345 260799012919 Domain of unknown function DUF11; Region: DUF11; cl17728 260799012920 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 260799012921 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 260799012922 Procyclic acidic repetitive protein (PARP); Region: Trypan_PARP; pfam05887 260799012923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 260799012924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799012925 H+ Antiporter protein; Region: 2A0121; TIGR00900 260799012926 putative substrate translocation pore; other site 260799012927 Helix-turn-helix domain; Region: HTH_36; pfam13730 260799012928 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 260799012929 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 260799012930 putative DNA binding site [nucleotide binding]; other site 260799012931 dimerization interface [polypeptide binding]; other site 260799012932 Protein of unknown function (DUF523); Region: DUF523; pfam04463 260799012933 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 260799012934 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 260799012935 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 260799012936 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 260799012937 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 260799012938 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 260799012939 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 260799012940 hypothetical protein; Provisional; Region: PRK13669 260799012941 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 260799012942 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 260799012943 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 260799012944 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 260799012945 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 260799012946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 260799012947 Walker A/P-loop; other site 260799012948 ATP binding site [chemical binding]; other site 260799012949 Q-loop/lid; other site 260799012950 ABC transporter signature motif; other site 260799012951 Walker B; other site 260799012952 D-loop; other site 260799012953 H-loop/switch region; other site 260799012954 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 260799012955 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 260799012956 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 260799012957 PhnA protein; Region: PhnA; pfam03831 260799012958 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 260799012959 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 260799012960 PQQ-like domain; Region: PQQ_2; pfam13360 260799012961 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 260799012962 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 260799012963 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 260799012964 CAAX protease self-immunity; Region: Abi; pfam02517 260799012965 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 260799012966 active site 260799012967 NTP binding site [chemical binding]; other site 260799012968 metal binding triad [ion binding]; metal-binding site 260799012969 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 260799012970 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 260799012971 NifU-like domain; Region: NifU; pfam01106 260799012972 spore coat protein YutH; Region: spore_yutH; TIGR02905 260799012973 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 260799012974 tetramer interfaces [polypeptide binding]; other site 260799012975 binuclear metal-binding site [ion binding]; other site 260799012976 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 260799012977 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 260799012978 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 260799012979 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 260799012980 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799012981 active site 260799012982 motif I; other site 260799012983 motif II; other site 260799012984 Predicted transcriptional regulator [Transcription]; Region: COG2345 260799012985 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799012986 putative Zn2+ binding site [ion binding]; other site 260799012987 putative DNA binding site [nucleotide binding]; other site 260799012988 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 260799012989 Uncharacterized conserved protein [Function unknown]; Region: COG2445 260799012990 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 260799012991 putative active site [active] 260799012992 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 260799012993 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 260799012994 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 260799012995 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 260799012996 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 260799012997 DNA binding residues [nucleotide binding] 260799012998 dimer interface [polypeptide binding]; other site 260799012999 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 260799013000 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 260799013001 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 260799013002 catalytic core [active] 260799013003 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 260799013004 putative deacylase active site [active] 260799013005 lipoyl synthase; Provisional; Region: PRK05481 260799013006 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 260799013007 FeS/SAM binding site; other site 260799013008 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 260799013009 Peptidase family M23; Region: Peptidase_M23; pfam01551 260799013010 sporulation protein YunB; Region: spo_yunB; TIGR02832 260799013011 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 260799013012 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 260799013013 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 260799013014 active site 260799013015 metal binding site [ion binding]; metal-binding site 260799013016 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 260799013017 Transcriptional regulator PadR-like family; Region: PadR; cl17335 260799013018 VanZ like family; Region: VanZ; pfam04892 260799013019 FeS assembly protein SufB; Region: sufB; TIGR01980 260799013020 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 260799013021 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 260799013022 trimerization site [polypeptide binding]; other site 260799013023 active site 260799013024 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 260799013025 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 260799013026 catalytic residue [active] 260799013027 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 260799013028 FeS assembly protein SufD; Region: sufD; TIGR01981 260799013029 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 260799013030 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 260799013031 Walker A/P-loop; other site 260799013032 ATP binding site [chemical binding]; other site 260799013033 Q-loop/lid; other site 260799013034 ABC transporter signature motif; other site 260799013035 Walker B; other site 260799013036 D-loop; other site 260799013037 H-loop/switch region; other site 260799013038 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 260799013039 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 260799013040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 260799013041 dimer interface [polypeptide binding]; other site 260799013042 conserved gate region; other site 260799013043 putative PBP binding loops; other site 260799013044 ABC-ATPase subunit interface; other site 260799013045 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 260799013046 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 260799013047 Walker A/P-loop; other site 260799013048 ATP binding site [chemical binding]; other site 260799013049 Q-loop/lid; other site 260799013050 ABC transporter signature motif; other site 260799013051 Walker B; other site 260799013052 D-loop; other site 260799013053 H-loop/switch region; other site 260799013054 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 260799013055 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 260799013056 catalytic residues [active] 260799013057 Small primase-like proteins (Toprim domain) [DNA replication, recombination, and repair]; Region: COG1658 260799013058 active site 260799013059 metal binding site [ion binding]; metal-binding site 260799013060 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 260799013061 lipoyl attachment site [posttranslational modification]; other site 260799013062 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 260799013063 putative ArsC-like catalytic residues; other site 260799013064 putative TRX-like catalytic residues [active] 260799013065 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 260799013066 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 260799013067 active site 260799013068 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 260799013069 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 260799013070 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 260799013071 tetramer (dimer of dimers) interface [polypeptide binding]; other site 260799013072 NAD binding site [chemical binding]; other site 260799013073 dimer interface [polypeptide binding]; other site 260799013074 substrate binding site [chemical binding]; other site 260799013075 Coat F domain; Region: Coat_F; pfam07875 260799013076 CAAX protease self-immunity; Region: Abi; pfam02517 260799013077 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799013078 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 260799013079 WHG domain; Region: WHG; pfam13305 260799013080 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 260799013081 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 260799013082 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 260799013083 active site 260799013084 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 260799013085 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 260799013086 dimer interface [polypeptide binding]; other site 260799013087 active site 260799013088 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 260799013089 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 260799013090 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 260799013091 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 260799013092 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 260799013093 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 260799013094 substrate binding site [chemical binding]; other site 260799013095 oxyanion hole (OAH) forming residues; other site 260799013096 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 260799013097 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 260799013098 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 260799013099 Proline dehydrogenase; Region: Pro_dh; pfam01619 260799013100 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 260799013101 Domain of unknown function DUF77; Region: DUF77; pfam01910 260799013102 Cache domain; Region: Cache_1; pfam02743 260799013103 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799013104 dimerization interface [polypeptide binding]; other site 260799013105 Microvirus H protein (pilot protein); Region: Microvir_H; cl11620 260799013106 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 260799013107 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 260799013108 dimer interface [polypeptide binding]; other site 260799013109 putative CheW interface [polypeptide binding]; other site 260799013110 Predicted transcriptional regulators [Transcription]; Region: COG1378 260799013111 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 260799013112 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 260799013113 C-terminal domain interface [polypeptide binding]; other site 260799013114 sugar binding site [chemical binding]; other site 260799013115 TQXA domain; Region: TQXA_dom; TIGR03934 260799013116 Cna protein B-type domain; Region: Cna_B; pfam05738 260799013117 Cna protein B-type domain; Region: Cna_B; pfam05738 260799013118 Cna protein B-type domain; Region: Cna_B; pfam05738 260799013119 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 260799013120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799013121 putative substrate translocation pore; other site 260799013122 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 260799013123 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 260799013124 MAEBL; Provisional; Region: PTZ00121 260799013125 OxaA-like protein precursor; Validated; Region: PRK01622 260799013126 Uncharacterized conserved protein [Function unknown]; Region: COG1284 260799013127 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 260799013128 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 260799013129 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 260799013130 hypothetical protein; Provisional; Region: PRK06758 260799013131 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 260799013132 active site 260799013133 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799013134 non-specific DNA binding site [nucleotide binding]; other site 260799013135 salt bridge; other site 260799013136 sequence-specific DNA binding site [nucleotide binding]; other site 260799013137 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 260799013138 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 260799013139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 260799013140 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 260799013141 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799013142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799013143 active site 260799013144 phosphorylation site [posttranslational modification] 260799013145 intermolecular recognition site; other site 260799013146 dimerization interface [polypeptide binding]; other site 260799013147 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799013148 DNA binding site [nucleotide binding] 260799013149 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 260799013150 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799013151 dimer interface [polypeptide binding]; other site 260799013152 phosphorylation site [posttranslational modification] 260799013153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799013154 ATP binding site [chemical binding]; other site 260799013155 Mg2+ binding site [ion binding]; other site 260799013156 G-X-G motif; other site 260799013157 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 260799013158 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 260799013159 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 260799013160 active site 260799013161 HIGH motif; other site 260799013162 KMSKS motif; other site 260799013163 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 260799013164 tRNA binding surface [nucleotide binding]; other site 260799013165 anticodon binding site; other site 260799013166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799013167 S-adenosylmethionine binding site [chemical binding]; other site 260799013168 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 260799013169 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799013170 dimerization interface [polypeptide binding]; other site 260799013171 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 260799013172 dimer interface [polypeptide binding]; other site 260799013173 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 260799013174 dimer interface [polypeptide binding]; other site 260799013175 putative CheW interface [polypeptide binding]; other site 260799013176 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 260799013177 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 260799013178 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 260799013179 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 260799013180 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 260799013181 active site 260799013182 Zn binding site [ion binding]; other site 260799013183 Pirin-related protein [General function prediction only]; Region: COG1741 260799013184 Pirin; Region: Pirin; pfam02678 260799013185 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 260799013186 Transcriptional regulators [Transcription]; Region: MarR; COG1846 260799013187 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 260799013188 putative Zn2+ binding site [ion binding]; other site 260799013189 putative DNA binding site [nucleotide binding]; other site 260799013190 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 260799013191 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 260799013192 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 260799013193 TrkA-C domain; Region: TrkA_C; pfam02080 260799013194 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 260799013195 Ferritin-like domain; Region: Ferritin; pfam00210 260799013196 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 260799013197 dimerization interface [polypeptide binding]; other site 260799013198 DPS ferroxidase diiron center [ion binding]; other site 260799013199 ion pore; other site 260799013200 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 260799013201 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 260799013202 metal binding site [ion binding]; metal-binding site 260799013203 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 260799013204 Ferritin-like domain; Region: Ferritin; pfam00210 260799013205 ferroxidase diiron center [ion binding]; other site 260799013206 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 260799013207 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 260799013208 Nucleoside recognition; Region: Gate; pfam07670 260799013209 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 260799013210 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 260799013211 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 260799013212 Nucleoside recognition; Region: Gate; pfam07670 260799013213 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 260799013214 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 260799013215 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 260799013216 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 260799013217 NAD binding site [chemical binding]; other site 260799013218 substrate binding site [chemical binding]; other site 260799013219 putative active site [active] 260799013220 TQXA domain; Region: TQXA_dom; TIGR03934 260799013221 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 260799013222 active site 260799013223 catalytic tetrad [active] 260799013224 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 260799013225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799013226 putative substrate translocation pore; other site 260799013227 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799013228 dimerization interface [polypeptide binding]; other site 260799013229 putative DNA binding site [nucleotide binding]; other site 260799013230 putative Zn2+ binding site [ion binding]; other site 260799013231 Uncharacterized conserved protein [Function unknown]; Region: COG2427 260799013232 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 260799013233 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 260799013234 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 260799013235 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 260799013236 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 260799013237 active site 260799013238 HIGH motif; other site 260799013239 dimer interface [polypeptide binding]; other site 260799013240 KMSKS motif; other site 260799013241 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 260799013242 RNA binding surface [nucleotide binding]; other site 260799013243 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 260799013244 FAD binding domain; Region: FAD_binding_4; pfam01565 260799013245 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 260799013246 SET domain; Region: SET; pfam00856 260799013247 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 260799013248 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 260799013249 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 260799013250 dimer interface [polypeptide binding]; other site 260799013251 putative CheW interface [polypeptide binding]; other site 260799013252 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 260799013253 putative phosphate binding site [ion binding]; other site 260799013254 camphor resistance protein CrcB; Provisional; Region: PRK14219 260799013255 camphor resistance protein CrcB; Provisional; Region: PRK14205 260799013256 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 260799013257 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 260799013258 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 260799013259 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 260799013260 Coenzyme A binding pocket [chemical binding]; other site 260799013261 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 260799013262 Nuclease-related domain; Region: NERD; pfam08378 260799013263 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 260799013264 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 260799013265 Walker A/P-loop; other site 260799013266 ATP binding site [chemical binding]; other site 260799013267 Q-loop/lid; other site 260799013268 ABC transporter signature motif; other site 260799013269 Walker B; other site 260799013270 D-loop; other site 260799013271 H-loop/switch region; other site 260799013272 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 260799013273 ABC-ATPase subunit interface; other site 260799013274 dimer interface [polypeptide binding]; other site 260799013275 putative PBP binding regions; other site 260799013276 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 260799013277 ABC-ATPase subunit interface; other site 260799013278 dimer interface [polypeptide binding]; other site 260799013279 putative PBP binding regions; other site 260799013280 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 260799013281 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 260799013282 putative ligand binding residues [chemical binding]; other site 260799013283 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799013284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799013285 active site 260799013286 phosphorylation site [posttranslational modification] 260799013287 intermolecular recognition site; other site 260799013288 dimerization interface [polypeptide binding]; other site 260799013289 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799013290 DNA binding site [nucleotide binding] 260799013291 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 260799013292 SmpB-tmRNA interface; other site 260799013293 ribonuclease R; Region: RNase_R; TIGR02063 260799013294 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 260799013295 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 260799013296 RNB domain; Region: RNB; pfam00773 260799013297 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 260799013298 RNA binding site [nucleotide binding]; other site 260799013299 Esterase/lipase [General function prediction only]; Region: COG1647 260799013300 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 260799013301 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 260799013302 holin-like protein; Validated; Region: PRK01658 260799013303 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 260799013304 active site 260799013305 NUMOD4 motif; Region: NUMOD4; pfam07463 260799013306 HNH endonuclease; Region: HNH_3; pfam13392 260799013307 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 260799013308 Helix-turn-helix domain; Region: HTH_17; pfam12728 260799013309 Phage Terminase; Region: Terminase_1; cl19862 260799013310 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 260799013311 active site 260799013312 Phage portal protein; Region: Phage_portal; pfam04860 260799013313 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 260799013314 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 260799013315 Phage capsid family; Region: Phage_capsid; pfam05065 260799013316 Phage capsid family; Region: Phage_capsid; pfam05065 260799013317 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 260799013318 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 260799013319 active site 260799013320 DNA binding site [nucleotide binding] 260799013321 Int/Topo IB signature motif; other site 260799013322 enolase; Provisional; Region: eno; PRK00077 260799013323 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 260799013324 dimer interface [polypeptide binding]; other site 260799013325 metal binding site [ion binding]; metal-binding site 260799013326 substrate binding pocket [chemical binding]; other site 260799013327 phosphoglyceromutase; Provisional; Region: PRK05434 260799013328 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 260799013329 substrate binding site [chemical binding]; other site 260799013330 dimer interface [polypeptide binding]; other site 260799013331 catalytic triad [active] 260799013332 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 260799013333 substrate binding site [chemical binding]; other site 260799013334 hinge regions; other site 260799013335 ADP binding site [chemical binding]; other site 260799013336 catalytic site [active] 260799013337 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 260799013338 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 260799013339 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 260799013340 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 260799013341 Predicted transcriptional regulator [Transcription]; Region: COG3388 260799013342 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 260799013343 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 260799013344 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 260799013345 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 260799013346 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 260799013347 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 260799013348 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 260799013349 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 260799013350 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 260799013351 stage V sporulation protein AD; Provisional; Region: PRK12404 260799013352 stage V sporulation protein AD; Region: spore_V_AD; TIGR02845 260799013353 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 260799013354 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 260799013355 Predicted membrane protein [Function unknown]; Region: COG2323 260799013356 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 260799013357 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 260799013358 oligomer interface [polypeptide binding]; other site 260799013359 active site residues [active] 260799013360 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 260799013361 dimerization domain swap beta strand [polypeptide binding]; other site 260799013362 regulatory protein interface [polypeptide binding]; other site 260799013363 active site 260799013364 regulatory phosphorylation site [posttranslational modification]; other site 260799013365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 260799013366 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 260799013367 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 260799013368 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 260799013369 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 260799013370 phosphate binding site [ion binding]; other site 260799013371 putative substrate binding pocket [chemical binding]; other site 260799013372 dimer interface [polypeptide binding]; other site 260799013373 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 260799013374 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 260799013375 putative active site [active] 260799013376 nucleotide binding site [chemical binding]; other site 260799013377 nudix motif; other site 260799013378 putative metal binding site [ion binding]; other site 260799013379 Domain of unknown function (DUF368); Region: DUF368; pfam04018 260799013380 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 260799013381 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 260799013382 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 260799013383 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799013384 binding surface 260799013385 TPR motif; other site 260799013386 Tetratricopeptide repeat; Region: TPR_12; pfam13424 260799013387 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 260799013388 binding surface 260799013389 Tetratricopeptide repeat; Region: TPR_16; pfam13432 260799013390 TPR motif; other site 260799013391 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 260799013392 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 260799013393 trimer interface [polypeptide binding]; other site 260799013394 active site 260799013395 substrate binding site [chemical binding]; other site 260799013396 CoA binding site [chemical binding]; other site 260799013397 pyrophosphatase PpaX; Provisional; Region: PRK13288 260799013398 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799013399 active site 260799013400 motif I; other site 260799013401 motif II; other site 260799013402 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 260799013403 HPr kinase/phosphorylase; Provisional; Region: PRK05428 260799013404 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 260799013405 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 260799013406 Hpr binding site; other site 260799013407 active site 260799013408 homohexamer subunit interaction site [polypeptide binding]; other site 260799013409 Predicted membrane protein [Function unknown]; Region: COG1950 260799013410 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 260799013411 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 260799013412 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 260799013413 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 260799013414 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 260799013415 excinuclease ABC subunit B; Provisional; Region: PRK05298 260799013416 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 260799013417 ATP binding site [chemical binding]; other site 260799013418 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 260799013419 nucleotide binding region [chemical binding]; other site 260799013420 ATP-binding site [chemical binding]; other site 260799013421 Ultra-violet resistance protein B; Region: UvrB; pfam12344 260799013422 UvrB/uvrC motif; Region: UVR; pfam02151 260799013423 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 260799013424 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 260799013425 Probable transposase; Region: OrfB_IS605; pfam01385 260799013426 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 260799013427 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 260799013428 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 260799013429 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 260799013430 DNA binding residues [nucleotide binding] 260799013431 dimer interface [polypeptide binding]; other site 260799013432 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 260799013433 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 260799013434 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799013435 non-specific DNA binding site [nucleotide binding]; other site 260799013436 salt bridge; other site 260799013437 sequence-specific DNA binding site [nucleotide binding]; other site 260799013438 Predicted membrane protein [Function unknown]; Region: COG2855 260799013439 Transcriptional regulator [Transcription]; Region: LysR; COG0583 260799013440 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 260799013441 Retrotransposon hot spot protein; Region: RHSP; cl19421 260799013442 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 260799013443 putative dimerization interface [polypeptide binding]; other site 260799013444 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 260799013445 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 260799013446 DNA binding residues [nucleotide binding] 260799013447 putative dimer interface [polypeptide binding]; other site 260799013448 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 260799013449 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 260799013450 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 260799013451 ABC transporter; Region: ABC_tran_2; pfam12848 260799013452 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 260799013453 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 260799013454 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 260799013455 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 260799013456 Walker A/P-loop; other site 260799013457 ATP binding site [chemical binding]; other site 260799013458 Q-loop/lid; other site 260799013459 ABC transporter signature motif; other site 260799013460 Walker B; other site 260799013461 D-loop; other site 260799013462 H-loop/switch region; other site 260799013463 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 260799013464 protein binding site [polypeptide binding]; other site 260799013465 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 260799013466 C-terminal peptidase (prc); Region: prc; TIGR00225 260799013467 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 260799013468 protein binding site [polypeptide binding]; other site 260799013469 Catalytic dyad [active] 260799013470 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 260799013471 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 260799013472 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 260799013473 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 260799013474 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 260799013475 Walker A/P-loop; other site 260799013476 ATP binding site [chemical binding]; other site 260799013477 Q-loop/lid; other site 260799013478 ABC transporter signature motif; other site 260799013479 Walker B; other site 260799013480 D-loop; other site 260799013481 H-loop/switch region; other site 260799013482 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 260799013483 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 260799013484 peptide chain release factor 2; Provisional; Region: PRK06746 260799013485 This domain is found in peptide chain release factors; Region: PCRF; smart00937 260799013486 RF-1 domain; Region: RF-1; pfam00472 260799013487 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 260799013488 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 260799013489 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 260799013490 nucleotide binding region [chemical binding]; other site 260799013491 ATP-binding site [chemical binding]; other site 260799013492 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 260799013493 SEC-C motif; Region: SEC-C; cl19389 260799013494 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 260799013495 30S subunit binding site; other site 260799013496 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 260799013497 DNA-binding site [nucleotide binding]; DNA binding site 260799013498 RNA-binding motif; other site 260799013499 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 260799013500 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 260799013501 active site 260799013502 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 260799013503 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 260799013504 ATP binding site [chemical binding]; other site 260799013505 putative Mg++ binding site [ion binding]; other site 260799013506 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 260799013507 nucleotide binding region [chemical binding]; other site 260799013508 ATP-binding site [chemical binding]; other site 260799013509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 260799013510 Sperm tail; Region: NYD-SP28; pfam14772 260799013511 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 260799013512 NlpC/P60 family; Region: NLPC_P60; pfam00877 260799013513 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 260799013514 dimerization interface [polypeptide binding]; other site 260799013515 putative DNA binding site [nucleotide binding]; other site 260799013516 putative Zn2+ binding site [ion binding]; other site 260799013517 EDD domain protein, DegV family; Region: DegV; TIGR00762 260799013518 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 260799013519 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 260799013520 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 260799013521 Transcriptional regulator [Transcription]; Region: LytR; COG1316 260799013522 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 260799013523 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 260799013524 active site 260799013525 homodimer interface [polypeptide binding]; other site 260799013526 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 260799013527 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 260799013528 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 260799013529 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 260799013530 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 260799013531 Mg++ binding site [ion binding]; other site 260799013532 putative catalytic motif [active] 260799013533 substrate binding site [chemical binding]; other site 260799013534 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 260799013535 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 260799013536 NodB motif; other site 260799013537 active site 260799013538 catalytic site [active] 260799013539 Zn binding site [ion binding]; other site 260799013540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 260799013541 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 260799013542 Walker A motif; other site 260799013543 ATP binding site [chemical binding]; other site 260799013544 Walker B motif; other site 260799013545 arginine finger; other site 260799013546 Transcriptional antiterminator [Transcription]; Region: COG3933 260799013547 PRD domain; Region: PRD; pfam00874 260799013548 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 260799013549 active pocket/dimerization site; other site 260799013550 active site 260799013551 phosphorylation site [posttranslational modification] 260799013552 PRD domain; Region: PRD; pfam00874 260799013553 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 260799013554 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 260799013555 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 260799013556 Chromate transporter; Region: Chromate_transp; pfam02417 260799013557 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 260799013558 putative active site [active] 260799013559 YdjC motif; other site 260799013560 Mg binding site [ion binding]; other site 260799013561 putative homodimer interface [polypeptide binding]; other site 260799013562 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 260799013563 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 260799013564 NAD binding site [chemical binding]; other site 260799013565 sugar binding site [chemical binding]; other site 260799013566 divalent metal binding site [ion binding]; other site 260799013567 tetramer (dimer of dimers) interface [polypeptide binding]; other site 260799013568 dimer interface [polypeptide binding]; other site 260799013569 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 260799013570 active site 260799013571 methionine cluster; other site 260799013572 phosphorylation site [posttranslational modification] 260799013573 metal binding site [ion binding]; metal-binding site 260799013574 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 260799013575 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 260799013576 active site 260799013577 P-loop; other site 260799013578 phosphorylation site [posttranslational modification] 260799013579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799013580 S-adenosylmethionine binding site [chemical binding]; other site 260799013581 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 260799013582 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 260799013583 methionine cluster; other site 260799013584 active site 260799013585 phosphorylation site [posttranslational modification] 260799013586 metal binding site [ion binding]; metal-binding site 260799013587 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 260799013588 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 260799013589 active site 260799013590 P-loop; other site 260799013591 phosphorylation site [posttranslational modification] 260799013592 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 260799013593 Acyltransferase family; Region: Acyl_transf_3; pfam01757 260799013594 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 260799013595 Predicted membrane protein [Function unknown]; Region: COG1511 260799013596 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 260799013597 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 260799013598 Transcriptional regulator [Transcription]; Region: LysR; COG0583 260799013599 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 260799013600 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 260799013601 dimerization interface [polypeptide binding]; other site 260799013602 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 260799013603 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 260799013604 Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219 260799013605 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 260799013606 transmembrane helices; other site 260799013607 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 260799013608 ThiC-associated domain; Region: ThiC-associated; pfam13667 260799013609 ThiC family; Region: ThiC; pfam01964 260799013610 L-lactate permease; Region: Lactate_perm; cl00701 260799013611 Tic20-like protein; Region: Tic20; pfam09685 260799013612 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 260799013613 Uncharacterized conserved protein [Function unknown]; Region: COG3339 260799013614 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 260799013615 Sulfatase; Region: Sulfatase; pfam00884 260799013616 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 260799013617 homodimer interface [polypeptide binding]; other site 260799013618 substrate-cofactor binding pocket; other site 260799013619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799013620 catalytic residue [active] 260799013621 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 260799013622 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 260799013623 Nucleoside recognition; Region: Gate; pfam07670 260799013624 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 260799013625 Uncharacterized conserved protein (DUF2215); Region: DUF2215; pfam10225 260799013626 rod shape-determining protein MreC; Region: MreC; cl19252 260799013627 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 260799013628 BCCT family transporter; Region: BCCT; pfam02028 260799013629 Bacterial SH3 domain; Region: SH3_3; pfam08239 260799013630 Bacterial SH3 domain homologues; Region: SH3b; smart00287 260799013631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 260799013632 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 260799013633 Predicted membrane protein [Function unknown]; Region: COG4640 260799013634 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 260799013635 Double zinc ribbon; Region: DZR; pfam12773 260799013636 Double zinc ribbon; Region: DZR; pfam12773 260799013637 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 260799013638 Uncharacterized conserved protein [Function unknown]; Region: COG4715 260799013639 SNF2 Helicase protein; Region: DUF3670; pfam12419 260799013640 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 260799013641 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 260799013642 ATP binding site [chemical binding]; other site 260799013643 putative Mg++ binding site [ion binding]; other site 260799013644 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 260799013645 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 260799013646 nucleotide binding region [chemical binding]; other site 260799013647 ATP-binding site [chemical binding]; other site 260799013648 Predicted integral membrane protein [Function unknown]; Region: COG5652 260799013649 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 260799013650 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 260799013651 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 260799013652 ComK protein; Region: ComK; cl11560 260799013653 RNA polymerase factor sigma-70; Validated; Region: PRK06759 260799013654 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799013655 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 260799013656 DNA binding residues [nucleotide binding] 260799013657 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 260799013658 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 260799013659 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 260799013660 FtsX-like permease family; Region: FtsX; pfam02687 260799013661 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 260799013662 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 260799013663 Walker A/P-loop; other site 260799013664 ATP binding site [chemical binding]; other site 260799013665 Q-loop/lid; other site 260799013666 ABC transporter signature motif; other site 260799013667 Walker B; other site 260799013668 D-loop; other site 260799013669 H-loop/switch region; other site 260799013670 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 260799013671 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 260799013672 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 260799013673 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799013674 non-specific DNA binding site [nucleotide binding]; other site 260799013675 salt bridge; other site 260799013676 sequence-specific DNA binding site [nucleotide binding]; other site 260799013677 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 260799013678 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 260799013679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799013680 putative substrate translocation pore; other site 260799013681 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 260799013682 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 260799013683 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 260799013684 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799013685 dimerization interface [polypeptide binding]; other site 260799013686 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799013687 dimer interface [polypeptide binding]; other site 260799013688 phosphorylation site [posttranslational modification] 260799013689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799013690 ATP binding site [chemical binding]; other site 260799013691 Mg2+ binding site [ion binding]; other site 260799013692 G-X-G motif; other site 260799013693 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799013694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799013695 active site 260799013696 phosphorylation site [posttranslational modification] 260799013697 intermolecular recognition site; other site 260799013698 dimerization interface [polypeptide binding]; other site 260799013699 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799013700 DNA binding site [nucleotide binding] 260799013701 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 260799013702 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 260799013703 NAD binding site [chemical binding]; other site 260799013704 homodimer interface [polypeptide binding]; other site 260799013705 active site 260799013706 substrate binding site [chemical binding]; other site 260799013707 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 260799013708 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 260799013709 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 260799013710 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 260799013711 active site 260799013712 homodimer interface [polypeptide binding]; other site 260799013713 teichoic acids export protein ATP-binding subunit; Provisional; Region: tagH; PRK13545 260799013714 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 260799013715 Walker A/P-loop; other site 260799013716 ATP binding site [chemical binding]; other site 260799013717 Q-loop/lid; other site 260799013718 ABC transporter signature motif; other site 260799013719 Walker B; other site 260799013720 D-loop; other site 260799013721 H-loop/switch region; other site 260799013722 Bacterial SH3 domain; Region: SH3_3; pfam08239 260799013723 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 260799013724 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 260799013725 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 260799013726 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 260799013727 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 260799013728 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 260799013729 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 260799013730 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 260799013731 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 260799013732 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 260799013733 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 260799013734 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 260799013735 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 260799013736 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 260799013737 rod shape-determining protein Mbl; Provisional; Region: PRK13928 260799013738 MreB and similar proteins; Region: MreB_like; cd10225 260799013739 nucleotide binding site [chemical binding]; other site 260799013740 Mg binding site [ion binding]; other site 260799013741 putative protofilament interaction site [polypeptide binding]; other site 260799013742 RodZ interaction site [polypeptide binding]; other site 260799013743 sporulation transcriptional regulator SpoIIID; Region: spore_III_D; TIGR02844 260799013744 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 260799013745 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 260799013746 Peptidase family M23; Region: Peptidase_M23; pfam01551 260799013747 ABC-2 type transporter; Region: ABC2_membrane; cl17235 260799013748 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 260799013749 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 260799013750 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 260799013751 Walker A/P-loop; other site 260799013752 ATP binding site [chemical binding]; other site 260799013753 Q-loop/lid; other site 260799013754 ABC transporter signature motif; other site 260799013755 Walker B; other site 260799013756 D-loop; other site 260799013757 H-loop/switch region; other site 260799013758 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 260799013759 LytTr DNA-binding domain; Region: LytTR; smart00850 260799013760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 260799013761 Walker A/P-loop; other site 260799013762 ATP binding site [chemical binding]; other site 260799013763 Q-loop/lid; other site 260799013764 ABC transporter signature motif; other site 260799013765 Walker B; other site 260799013766 D-loop; other site 260799013767 stage II sporulation protein D; Region: spore_II_D; TIGR02870 260799013768 Stage II sporulation protein; Region: SpoIID; pfam08486 260799013769 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 260799013770 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 260799013771 hinge; other site 260799013772 active site 260799013773 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 260799013774 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 260799013775 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 260799013776 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 260799013777 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 260799013778 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 260799013779 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 260799013780 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 260799013781 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 260799013782 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 260799013783 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 260799013784 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 260799013785 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 260799013786 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 260799013787 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 260799013788 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 260799013789 NADH dehydrogenase subunit C; Validated; Region: PRK07735 260799013790 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl19197 260799013791 NADH dehydrogenase subunit B; Validated; Region: PRK06411 260799013792 NADH dehydrogenase subunit A; Validated; Region: PRK07756 260799013793 PAS domain; Region: PAS_9; pfam13426 260799013794 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 260799013795 putative active site [active] 260799013796 heme pocket [chemical binding]; other site 260799013797 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 260799013798 metal binding site [ion binding]; metal-binding site 260799013799 active site 260799013800 I-site; other site 260799013801 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 260799013802 Protein of unknown function (DUF975); Region: DUF975; cl10504 260799013803 Protein of unknown function (DUF975); Region: DUF975; cl10504 260799013804 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 260799013805 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 260799013806 gamma subunit interface [polypeptide binding]; other site 260799013807 epsilon subunit interface [polypeptide binding]; other site 260799013808 LBP interface [polypeptide binding]; other site 260799013809 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 260799013810 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 260799013811 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 260799013812 alpha subunit interaction interface [polypeptide binding]; other site 260799013813 Walker A motif; other site 260799013814 ATP binding site [chemical binding]; other site 260799013815 Walker B motif; other site 260799013816 inhibitor binding site; inhibition site 260799013817 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 260799013818 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 260799013819 core domain interface [polypeptide binding]; other site 260799013820 delta subunit interface [polypeptide binding]; other site 260799013821 epsilon subunit interface [polypeptide binding]; other site 260799013822 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 260799013823 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 260799013824 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 260799013825 beta subunit interaction interface [polypeptide binding]; other site 260799013826 Walker A motif; other site 260799013827 ATP binding site [chemical binding]; other site 260799013828 Walker B motif; other site 260799013829 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 260799013830 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 260799013831 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 260799013832 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 260799013833 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 260799013834 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 260799013835 ATP synthase I chain; Region: ATP_synt_I; pfam03899 260799013836 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 260799013837 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 260799013838 active site 260799013839 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 260799013840 dimer interface [polypeptide binding]; other site 260799013841 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 260799013842 active site 260799013843 glycine-pyridoxal phosphate binding site [chemical binding]; other site 260799013844 folate binding site [chemical binding]; other site 260799013845 hypothetical protein; Provisional; Region: PRK13690 260799013846 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 260799013847 Low molecular weight phosphatase family; Region: LMWPc; cd00115 260799013848 active site 260799013849 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 260799013850 HPr interaction site; other site 260799013851 glycerol kinase (GK) interaction site [polypeptide binding]; other site 260799013852 active site 260799013853 phosphorylation site [posttranslational modification] 260799013854 Predicted membrane protein [Function unknown]; Region: COG2259 260799013855 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 260799013856 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 260799013857 Predicted membrane protein [Function unknown]; Region: COG1971 260799013858 Domain of unknown function DUF; Region: DUF204; pfam02659 260799013859 Domain of unknown function DUF; Region: DUF204; pfam02659 260799013860 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 260799013861 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 260799013862 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 260799013863 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 260799013864 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 260799013865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799013866 S-adenosylmethionine binding site [chemical binding]; other site 260799013867 peptide chain release factor 1; Validated; Region: prfA; PRK00591 260799013868 This domain is found in peptide chain release factors; Region: PCRF; smart00937 260799013869 RF-1 domain; Region: RF-1; pfam00472 260799013870 thymidine kinase; Provisional; Region: PRK04296 260799013871 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 260799013872 transcription termination factor Rho; Provisional; Region: rho; PRK09376 260799013873 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 260799013874 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 260799013875 RNA binding site [nucleotide binding]; other site 260799013876 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 260799013877 multimer interface [polypeptide binding]; other site 260799013878 Walker A motif; other site 260799013879 ATP binding site [chemical binding]; other site 260799013880 Walker B motif; other site 260799013881 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 260799013882 putative active site [active] 260799013883 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 260799013884 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 260799013885 hinge; other site 260799013886 active site 260799013887 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 260799013888 intersubunit interface [polypeptide binding]; other site 260799013889 active site 260799013890 zinc binding site [ion binding]; other site 260799013891 Na+ binding site [ion binding]; other site 260799013892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799013893 active site 260799013894 phosphorylation site [posttranslational modification] 260799013895 intermolecular recognition site; other site 260799013896 dimerization interface [polypeptide binding]; other site 260799013897 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 260799013898 CTP synthetase; Validated; Region: pyrG; PRK05380 260799013899 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 260799013900 Catalytic site [active] 260799013901 active site 260799013902 UTP binding site [chemical binding]; other site 260799013903 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 260799013904 active site 260799013905 putative oxyanion hole; other site 260799013906 catalytic triad [active] 260799013907 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 260799013908 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799013909 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799013910 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 260799013911 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 260799013912 FAD binding site [chemical binding]; other site 260799013913 homotetramer interface [polypeptide binding]; other site 260799013914 substrate binding pocket [chemical binding]; other site 260799013915 catalytic base [active] 260799013916 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 260799013917 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 260799013918 FAD binding site [chemical binding]; other site 260799013919 homotetramer interface [polypeptide binding]; other site 260799013920 substrate binding pocket [chemical binding]; other site 260799013921 catalytic base [active] 260799013922 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 260799013923 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 260799013924 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 260799013925 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 260799013926 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 260799013927 dimer interface [polypeptide binding]; other site 260799013928 active site 260799013929 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 260799013930 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 260799013931 Cysteine-rich domain; Region: CCG; pfam02754 260799013932 Cysteine-rich domain; Region: CCG; pfam02754 260799013933 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 260799013934 PLD-like domain; Region: PLDc_2; pfam13091 260799013935 putative active site [active] 260799013936 catalytic site [active] 260799013937 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 260799013938 PLD-like domain; Region: PLDc_2; pfam13091 260799013939 putative active site [active] 260799013940 catalytic site [active] 260799013941 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 260799013942 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 260799013943 PAS domain S-box; Region: sensory_box; TIGR00229 260799013944 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 260799013945 putative active site [active] 260799013946 heme pocket [chemical binding]; other site 260799013947 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 260799013948 metal binding site [ion binding]; metal-binding site 260799013949 active site 260799013950 I-site; other site 260799013951 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 260799013952 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 260799013953 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 260799013954 non-specific DNA binding site [nucleotide binding]; other site 260799013955 salt bridge; other site 260799013956 sequence-specific DNA binding site [nucleotide binding]; other site 260799013957 Tetratricopeptide repeat; Region: TPR_12; pfam13424 260799013958 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 260799013959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799013960 active site 260799013961 phosphorylation site [posttranslational modification] 260799013962 intermolecular recognition site; other site 260799013963 dimerization interface [polypeptide binding]; other site 260799013964 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 260799013965 DNA binding residues [nucleotide binding] 260799013966 dimerization interface [polypeptide binding]; other site 260799013967 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 260799013968 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 260799013969 Histidine kinase; Region: HisKA_3; pfam07730 260799013970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799013971 ATP binding site [chemical binding]; other site 260799013972 Mg2+ binding site [ion binding]; other site 260799013973 G-X-G motif; other site 260799013974 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 260799013975 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 260799013976 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 260799013977 Walker A/P-loop; other site 260799013978 ATP binding site [chemical binding]; other site 260799013979 Q-loop/lid; other site 260799013980 ABC transporter signature motif; other site 260799013981 Walker B; other site 260799013982 D-loop; other site 260799013983 H-loop/switch region; other site 260799013984 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 260799013985 active site 260799013986 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 260799013987 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 260799013988 PA/protease or protease-like domain interface [polypeptide binding]; other site 260799013989 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 260799013990 metal binding site [ion binding]; metal-binding site 260799013991 RNA polymerase sigma factor; Provisional; Region: PRK12522 260799013992 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 260799013993 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 260799013994 DNA binding residues [nucleotide binding] 260799013995 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 260799013996 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 260799013997 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 260799013998 active site 260799013999 HIGH motif; other site 260799014000 KMSK motif region; other site 260799014001 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 260799014002 tRNA binding surface [nucleotide binding]; other site 260799014003 anticodon binding site; other site 260799014004 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 260799014005 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 260799014006 putative dimer interface [polypeptide binding]; other site 260799014007 catalytic triad [active] 260799014008 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 260799014009 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 260799014010 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 260799014011 putative active site [active] 260799014012 Mn binding site [ion binding]; other site 260799014013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799014014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799014015 Major Facilitator Superfamily; Region: MFS_1; pfam07690 260799014016 putative substrate translocation pore; other site 260799014017 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 260799014018 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 260799014019 DNA binding residues [nucleotide binding] 260799014020 putative dimer interface [polypeptide binding]; other site 260799014021 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 260799014022 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 260799014023 active site 260799014024 catalytic site [active] 260799014025 metal binding site [ion binding]; metal-binding site 260799014026 dimer interface [polypeptide binding]; other site 260799014027 Transglycosylase; Region: Transgly; pfam00912 260799014028 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 260799014029 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 260799014030 YwhD family; Region: YwhD; pfam08741 260799014031 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 260799014032 Peptidase family M50; Region: Peptidase_M50; pfam02163 260799014033 active site 260799014034 putative substrate binding region [chemical binding]; other site 260799014035 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 260799014036 active site 1 [active] 260799014037 dimer interface [polypeptide binding]; other site 260799014038 hexamer interface [polypeptide binding]; other site 260799014039 active site 2 [active] 260799014040 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 260799014041 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 260799014042 Zn2+ binding site [ion binding]; other site 260799014043 Mg2+ binding site [ion binding]; other site 260799014044 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 260799014045 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 260799014046 intersubunit interface [polypeptide binding]; other site 260799014047 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 260799014048 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 260799014049 Walker A/P-loop; other site 260799014050 ATP binding site [chemical binding]; other site 260799014051 Q-loop/lid; other site 260799014052 ABC transporter signature motif; other site 260799014053 Walker B; other site 260799014054 D-loop; other site 260799014055 H-loop/switch region; other site 260799014056 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 260799014057 ABC-ATPase subunit interface; other site 260799014058 dimer interface [polypeptide binding]; other site 260799014059 putative PBP binding regions; other site 260799014060 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 260799014061 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 260799014062 hypothetical protein; Provisional; Region: PRK12473 260799014063 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 260799014064 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 260799014065 putative heme peroxidase; Provisional; Region: PRK12276 260799014066 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 260799014067 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 260799014068 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 260799014069 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 260799014070 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 260799014071 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 260799014072 Protein of unknown function (DUF423); Region: DUF423; pfam04241 260799014073 Sulfate transporter family; Region: Sulfate_transp; cl19250 260799014074 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 260799014075 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799014076 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 260799014077 motif II; other site 260799014078 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 260799014079 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 260799014080 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 260799014081 ligand binding site [chemical binding]; other site 260799014082 active site 260799014083 UGI interface [polypeptide binding]; other site 260799014084 catalytic site [active] 260799014085 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 260799014086 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 260799014087 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 260799014088 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 260799014089 Walker A/P-loop; other site 260799014090 ATP binding site [chemical binding]; other site 260799014091 Q-loop/lid; other site 260799014092 ABC transporter signature motif; other site 260799014093 Walker B; other site 260799014094 D-loop; other site 260799014095 H-loop/switch region; other site 260799014096 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 260799014097 active site 260799014098 catalytic triad [active] 260799014099 oxyanion hole [active] 260799014100 Transcriptional regulators [Transcription]; Region: PurR; COG1609 260799014101 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 260799014102 DNA binding site [nucleotide binding] 260799014103 domain linker motif; other site 260799014104 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 260799014105 putative dimerization interface [polypeptide binding]; other site 260799014106 putative ligand binding site [chemical binding]; other site 260799014107 Predicted membrane protein [Function unknown]; Region: COG2364 260799014108 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 260799014109 homoserine dehydrogenase; Provisional; Region: PRK06349 260799014110 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 260799014111 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 260799014112 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 260799014113 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 260799014114 proposed active site lysine [active] 260799014115 conserved cys residue [active] 260799014116 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 260799014117 homodimer interface [polypeptide binding]; other site 260799014118 substrate-cofactor binding pocket; other site 260799014119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 260799014120 catalytic residue [active] 260799014121 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 260799014122 Cl- selectivity filter; other site 260799014123 Cl- binding residues [ion binding]; other site 260799014124 pore gating glutamate residue; other site 260799014125 dimer interface [polypeptide binding]; other site 260799014126 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 260799014127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 260799014128 active site 260799014129 motif I; other site 260799014130 motif II; other site 260799014131 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 260799014132 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 260799014133 ligand binding site [chemical binding]; other site 260799014134 flexible hinge region; other site 260799014135 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 260799014136 azoreductase; Provisional; Region: PRK13556 260799014137 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 260799014138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799014139 active site 260799014140 phosphorylation site [posttranslational modification] 260799014141 intermolecular recognition site; other site 260799014142 dimerization interface [polypeptide binding]; other site 260799014143 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 260799014144 DNA binding residues [nucleotide binding] 260799014145 dimerization interface [polypeptide binding]; other site 260799014146 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 260799014147 dimer interface [polypeptide binding]; other site 260799014148 substrate binding site [chemical binding]; other site 260799014149 ATP binding site [chemical binding]; other site 260799014150 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 260799014151 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 260799014152 metal binding site [ion binding]; metal-binding site 260799014153 active site 260799014154 I-site; other site 260799014155 Protein of unknown function (DUF466); Region: DUF466; pfam04328 260799014156 carbon starvation protein A; Provisional; Region: PRK15015 260799014157 Carbon starvation protein CstA; Region: CstA; pfam02554 260799014158 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 260799014159 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 260799014160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799014161 active site 260799014162 phosphorylation site [posttranslational modification] 260799014163 intermolecular recognition site; other site 260799014164 dimerization interface [polypeptide binding]; other site 260799014165 LytTr DNA-binding domain; Region: LytTR; pfam04397 260799014166 benzoate transport; Region: 2A0115; TIGR00895 260799014167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799014168 putative substrate translocation pore; other site 260799014169 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 260799014170 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 260799014171 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 260799014172 Predicted membrane protein [Function unknown]; Region: COG2860 260799014173 UPF0126 domain; Region: UPF0126; pfam03458 260799014174 UPF0126 domain; Region: UPF0126; pfam03458 260799014175 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 260799014176 heme-binding site [chemical binding]; other site 260799014177 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 260799014178 dimer interface [polypeptide binding]; other site 260799014179 putative CheW interface [polypeptide binding]; other site 260799014180 conserved hypothetical integral membrane protein; Region: TIGR03766 260799014181 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 260799014182 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 260799014183 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 260799014184 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 260799014185 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 260799014186 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 260799014187 active site 260799014188 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 260799014189 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 260799014190 ABC transporter; Region: ABC_tran_2; pfam12848 260799014191 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 260799014192 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 260799014193 GtrA-like protein; Region: GtrA; pfam04138 260799014194 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 260799014195 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 260799014196 Ligand binding site; other site 260799014197 Putative Catalytic site; other site 260799014198 DXD motif; other site 260799014199 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 260799014200 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 260799014201 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 260799014202 MMPL family; Region: MMPL; cl14618 260799014203 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 260799014204 MMPL family; Region: MMPL; cl14618 260799014205 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 260799014206 methionine sulfoxide reductase B; Provisional; Region: PRK00222 260799014207 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 260799014208 antiholin-like protein LrgB; Provisional; Region: PRK04288 260799014209 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 260799014210 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 260799014211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799014212 active site 260799014213 phosphorylation site [posttranslational modification] 260799014214 intermolecular recognition site; other site 260799014215 dimerization interface [polypeptide binding]; other site 260799014216 LytTr DNA-binding domain; Region: LytTR; pfam04397 260799014217 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 260799014218 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 260799014219 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 260799014220 Histidine kinase; Region: His_kinase; pfam06580 260799014221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799014222 ATP binding site [chemical binding]; other site 260799014223 Mg2+ binding site [ion binding]; other site 260799014224 G-X-G motif; other site 260799014225 benzoate transport; Region: 2A0115; TIGR00895 260799014226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 260799014227 putative substrate translocation pore; other site 260799014228 BCCT family transporter; Region: BCCT; pfam02028 260799014229 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cl00254 260799014230 active site 260799014231 dimer interface [polypeptide binding]; other site 260799014232 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 260799014233 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 260799014234 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 260799014235 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 260799014236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 260799014237 NAD(P) binding site [chemical binding]; other site 260799014238 active site 260799014239 UreI/AmiS family, subgroup 2. Putative transporters related to proton-gated urea channel and putative amide transporters; Region: UreI_AmiS_like_2; cd13429 260799014240 hexamer interface [polypeptide binding]; other site 260799014241 transport channel [chemical binding]; other site 260799014242 constriction site 1 [chemical binding]; other site 260799014243 constriction site 2 [chemical binding]; other site 260799014244 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 260799014245 UDP-glucose 4-epimerase; Region: PLN02240 260799014246 NAD binding site [chemical binding]; other site 260799014247 homodimer interface [polypeptide binding]; other site 260799014248 active site 260799014249 substrate binding site [chemical binding]; other site 260799014250 Haemolysin-III related; Region: HlyIII; cl03831 260799014251 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 260799014252 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 260799014253 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 260799014254 ATP binding site [chemical binding]; other site 260799014255 Mg++ binding site [ion binding]; other site 260799014256 motif III; other site 260799014257 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 260799014258 nucleotide binding region [chemical binding]; other site 260799014259 ATP-binding site [chemical binding]; other site 260799014260 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 260799014261 RNA binding site [nucleotide binding]; other site 260799014262 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 260799014263 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 260799014264 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 260799014265 active site 260799014266 oligoendopeptidase F; Region: pepF; TIGR00181 260799014267 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 260799014268 active site 260799014269 Zn binding site [ion binding]; other site 260799014270 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 260799014271 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 260799014272 FeS/SAM binding site; other site 260799014273 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 260799014274 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 260799014275 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 260799014276 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 260799014277 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 260799014278 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 260799014279 protein binding site [polypeptide binding]; other site 260799014280 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 260799014281 YycH protein; Region: YycI; pfam09648 260799014282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 260799014283 YycH protein; Region: YycH; pfam07435 260799014284 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 260799014285 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 260799014286 dimerization interface [polypeptide binding]; other site 260799014287 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 260799014288 putative active site [active] 260799014289 heme pocket [chemical binding]; other site 260799014290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 260799014291 dimer interface [polypeptide binding]; other site 260799014292 phosphorylation site [posttranslational modification] 260799014293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 260799014294 ATP binding site [chemical binding]; other site 260799014295 Mg2+ binding site [ion binding]; other site 260799014296 G-X-G motif; other site 260799014297 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 260799014298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 260799014299 active site 260799014300 phosphorylation site [posttranslational modification] 260799014301 intermolecular recognition site; other site 260799014302 dimerization interface [polypeptide binding]; other site 260799014303 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 260799014304 DNA binding site [nucleotide binding] 260799014305 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 260799014306 GDP-binding site [chemical binding]; other site 260799014307 ACT binding site; other site 260799014308 IMP binding site; other site 260799014309 replicative DNA helicase; Provisional; Region: PRK05748 260799014310 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 260799014311 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 260799014312 Walker A motif; other site 260799014313 ATP binding site [chemical binding]; other site 260799014314 Walker B motif; other site 260799014315 DNA binding loops [nucleotide binding] 260799014316 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 260799014317 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 260799014318 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 260799014319 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 260799014320 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 260799014321 DHH family; Region: DHH; pfam01368 260799014322 DHHA1 domain; Region: DHHA1; pfam02272 260799014323 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 260799014324 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 260799014325 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 260799014326 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 260799014327 dimer interface [polypeptide binding]; other site 260799014328 ssDNA binding site [nucleotide binding]; other site 260799014329 tetramer (dimer of dimers) interface [polypeptide binding]; other site 260799014330 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 260799014331 GTP-binding protein YchF; Reviewed; Region: PRK09601 260799014332 YchF GTPase; Region: YchF; cd01900 260799014333 G1 box; other site 260799014334 GTP/Mg2+ binding site [chemical binding]; other site 260799014335 Switch I region; other site 260799014336 G2 box; other site 260799014337 Switch II region; other site 260799014338 G3 box; other site 260799014339 G4 box; other site 260799014340 G5 box; other site 260799014341 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 260799014342 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 260799014343 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 260799014344 Mechanosensitive ion channel; Region: MS_channel; pfam00924 260799014345 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 260799014346 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 260799014347 ParB-like nuclease domain; Region: ParB; smart00470 260799014348 KorB domain; Region: KorB; pfam08535 260799014349 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 260799014350 VirC1 protein; Region: VirC1; cl17401 260799014351 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 260799014352 P-loop; other site 260799014353 Magnesium ion binding site [ion binding]; other site 260799014354 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 260799014355 ParB-like nuclease domain; Region: ParBc; pfam02195 260799014356 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 260799014357 Methyltransferase domain; Region: Methyltransf_31; pfam13847 260799014358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 260799014359 S-adenosylmethionine binding site [chemical binding]; other site 260799014360 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 260799014361 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 260799014362 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 260799014363 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 260799014364 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 260799014365 trmE is a tRNA modification GTPase; Region: trmE; cd04164 260799014366 G1 box; other site 260799014367 GTP/Mg2+ binding site [chemical binding]; other site 260799014368 Switch I region; other site 260799014369 G2 box; other site 260799014370 Switch II region; other site 260799014371 G3 box; other site 260799014372 G4 box; other site 260799014373 G5 box; other site 260799014374 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 260799014375 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 260799014376 Jag N-terminus; Region: Jag_N; pfam14804 260799014377 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 260799014378 G-X-X-G motif; other site 260799014379 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 260799014380 RxxxH motif; other site 260799014381 OxaA-like protein precursor; Validated; Region: PRK02944 260799014382 ribonuclease P; Reviewed; Region: rnpA; PRK00499 260799014383 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399