-- dump date 20140618_213948 -- class Genbank::misc_feature -- table misc_feature_note -- id note 649639000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 649639000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 649639000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639000004 Walker A motif; other site 649639000005 ATP binding site [chemical binding]; other site 649639000006 Walker B motif; other site 649639000007 arginine finger; other site 649639000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 649639000009 DnaA box-binding interface [nucleotide binding]; other site 649639000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 649639000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 649639000012 putative DNA binding surface [nucleotide binding]; other site 649639000013 dimer interface [polypeptide binding]; other site 649639000014 beta-clamp/clamp loader binding surface; other site 649639000015 beta-clamp/translesion DNA polymerase binding surface; other site 649639000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 649639000017 recombination protein F; Reviewed; Region: recF; PRK00064 649639000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 649639000019 Walker A/P-loop; other site 649639000020 ATP binding site [chemical binding]; other site 649639000021 Q-loop/lid; other site 649639000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639000023 ABC transporter signature motif; other site 649639000024 Walker B; other site 649639000025 D-loop; other site 649639000026 H-loop/switch region; other site 649639000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 649639000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639000029 Mg2+ binding site [ion binding]; other site 649639000030 G-X-G motif; other site 649639000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 649639000032 anchoring element; other site 649639000033 dimer interface [polypeptide binding]; other site 649639000034 ATP binding site [chemical binding]; other site 649639000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 649639000036 active site 649639000037 putative metal-binding site [ion binding]; other site 649639000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 649639000039 DNA gyrase subunit A; Validated; Region: PRK05560 649639000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 649639000041 CAP-like domain; other site 649639000042 active site 649639000043 primary dimer interface [polypeptide binding]; other site 649639000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 649639000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 649639000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 649639000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 649639000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 649639000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 649639000050 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 649639000051 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 649639000052 tetramer interface [polypeptide binding]; other site 649639000053 heme binding pocket [chemical binding]; other site 649639000054 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 649639000055 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 649639000056 Zn2+ binding site [ion binding]; other site 649639000057 Mg2+ binding site [ion binding]; other site 649639000058 YaaC-like Protein; Region: YaaC; pfam14175 649639000059 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 649639000060 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 649639000061 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 649639000062 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 649639000063 active site 649639000064 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 649639000065 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 649639000066 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 649639000067 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 649639000068 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 649639000069 active site 649639000070 multimer interface [polypeptide binding]; other site 649639000071 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 649639000072 predicted active site [active] 649639000073 catalytic triad [active] 649639000074 seryl-tRNA synthetase; Provisional; Region: PRK05431 649639000075 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 649639000076 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 649639000077 dimer interface [polypeptide binding]; other site 649639000078 active site 649639000079 motif 1; other site 649639000080 motif 2; other site 649639000081 motif 3; other site 649639000082 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 649639000083 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 649639000084 Walker A/P-loop; other site 649639000085 ATP binding site [chemical binding]; other site 649639000086 Q-loop/lid; other site 649639000087 ABC transporter signature motif; other site 649639000088 Walker B; other site 649639000089 D-loop; other site 649639000090 H-loop/switch region; other site 649639000091 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 649639000092 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 649639000093 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 649639000094 Walker A/P-loop; other site 649639000095 ATP binding site [chemical binding]; other site 649639000096 Q-loop/lid; other site 649639000097 ABC transporter signature motif; other site 649639000098 Walker B; other site 649639000099 D-loop; other site 649639000100 H-loop/switch region; other site 649639000101 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 649639000102 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 649639000103 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 649639000104 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 649639000105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639000106 dimer interface [polypeptide binding]; other site 649639000107 conserved gate region; other site 649639000108 putative PBP binding loops; other site 649639000109 ABC-ATPase subunit interface; other site 649639000110 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 649639000111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639000112 dimer interface [polypeptide binding]; other site 649639000113 conserved gate region; other site 649639000114 putative PBP binding loops; other site 649639000115 ABC-ATPase subunit interface; other site 649639000116 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 649639000117 nucleoside/Zn binding site; other site 649639000118 dimer interface [polypeptide binding]; other site 649639000119 catalytic motif [active] 649639000120 YycC-like protein; Region: YycC; pfam14174 649639000121 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 649639000122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639000123 Walker A motif; other site 649639000124 ATP binding site [chemical binding]; other site 649639000125 Walker B motif; other site 649639000126 arginine finger; other site 649639000127 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 649639000128 hypothetical protein; Validated; Region: PRK00153 649639000129 recombination protein RecR; Reviewed; Region: recR; PRK00076 649639000130 RecR protein; Region: RecR; pfam02132 649639000131 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 649639000132 putative active site [active] 649639000133 putative metal-binding site [ion binding]; other site 649639000134 tetramer interface [polypeptide binding]; other site 649639000135 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 649639000136 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 649639000137 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 649639000138 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 649639000139 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 649639000140 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649639000141 catalytic residue [active] 649639000142 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 649639000143 thymidylate kinase; Validated; Region: tmk; PRK00698 649639000144 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 649639000145 TMP-binding site; other site 649639000146 ATP-binding site [chemical binding]; other site 649639000147 Protein of unknown function (DUF970); Region: DUF970; pfam06153 649639000148 DNA polymerase III subunit delta'; Validated; Region: PRK08058 649639000149 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 649639000150 Walker A motif; other site 649639000151 ATP binding site [chemical binding]; other site 649639000152 Walker B motif; other site 649639000153 arginine finger; other site 649639000154 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 649639000155 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 649639000156 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 649639000157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639000158 S-adenosylmethionine binding site [chemical binding]; other site 649639000159 Predicted methyltransferases [General function prediction only]; Region: COG0313 649639000160 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 649639000161 putative SAM binding site [chemical binding]; other site 649639000162 putative homodimer interface [polypeptide binding]; other site 649639000163 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 649639000164 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 649639000165 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 649639000166 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 649639000167 active site 649639000168 HIGH motif; other site 649639000169 KMSKS motif; other site 649639000170 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 649639000171 tRNA binding surface [nucleotide binding]; other site 649639000172 anticodon binding site; other site 649639000173 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 649639000174 dimer interface [polypeptide binding]; other site 649639000175 putative tRNA-binding site [nucleotide binding]; other site 649639000176 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 649639000177 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 649639000178 active site 649639000179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 649639000180 Domain of unknown function (DUF348); Region: DUF348; pfam03990 649639000181 Domain of unknown function (DUF348); Region: DUF348; pfam03990 649639000182 Domain of unknown function (DUF348); Region: DUF348; pfam03990 649639000183 G5 domain; Region: G5; pfam07501 649639000184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 649639000185 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 649639000186 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 649639000187 putative active site [active] 649639000188 putative metal binding site [ion binding]; other site 649639000189 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 649639000190 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 649639000191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639000192 S-adenosylmethionine binding site [chemical binding]; other site 649639000193 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 649639000194 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 649639000195 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 649639000196 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 649639000197 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 649639000198 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 649639000199 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 649639000200 pur operon repressor; Provisional; Region: PRK09213 649639000201 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 649639000202 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 649639000203 active site 649639000204 regulatory protein SpoVG; Reviewed; Region: PRK13259 649639000205 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 649639000206 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 649639000207 Substrate binding site; other site 649639000208 Mg++ binding site; other site 649639000209 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 649639000210 active site 649639000211 substrate binding site [chemical binding]; other site 649639000212 CoA binding site [chemical binding]; other site 649639000213 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 649639000214 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 649639000215 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 649639000216 active site 649639000217 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 649639000218 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 649639000219 5S rRNA interface [nucleotide binding]; other site 649639000220 CTC domain interface [polypeptide binding]; other site 649639000221 L16 interface [polypeptide binding]; other site 649639000222 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 649639000223 putative active site [active] 649639000224 catalytic residue [active] 649639000225 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 649639000226 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 649639000227 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 649639000228 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649639000229 ATP binding site [chemical binding]; other site 649639000230 putative Mg++ binding site [ion binding]; other site 649639000231 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649639000232 nucleotide binding region [chemical binding]; other site 649639000233 ATP-binding site [chemical binding]; other site 649639000234 TRCF domain; Region: TRCF; pfam03461 649639000235 stage V sporulation protein T; Region: spore_V_T; TIGR02851 649639000236 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 649639000237 stage V sporulation protein B; Region: spore_V_B; TIGR02900 649639000238 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 649639000239 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 649639000240 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 649639000241 putative SAM binding site [chemical binding]; other site 649639000242 putative homodimer interface [polypeptide binding]; other site 649639000243 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 649639000244 homodimer interface [polypeptide binding]; other site 649639000245 metal binding site [ion binding]; metal-binding site 649639000246 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 649639000247 homodimer interface [polypeptide binding]; other site 649639000248 active site 649639000249 putative chemical substrate binding site [chemical binding]; other site 649639000250 metal binding site [ion binding]; metal-binding site 649639000251 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 649639000252 RNA binding surface [nucleotide binding]; other site 649639000253 sporulation protein YabP; Region: spore_yabP; TIGR02892 649639000254 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 649639000255 Septum formation initiator; Region: DivIC; pfam04977 649639000256 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 649639000257 hypothetical protein; Provisional; Region: PRK08582 649639000258 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 649639000259 RNA binding site [nucleotide binding]; other site 649639000260 stage II sporulation protein E; Region: spore_II_E; TIGR02865 649639000261 ABC-2 type transporter; Region: ABC2_membrane; cl17235 649639000262 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 649639000263 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 649639000264 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 649639000265 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 649639000266 metal ion-dependent adhesion site (MIDAS); other site 649639000267 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 649639000268 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 649639000269 active site 649639000270 ATP binding site [chemical binding]; other site 649639000271 substrate binding site [chemical binding]; other site 649639000272 Uncharacterized conserved protein [Function unknown]; Region: COG2966 649639000273 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 649639000274 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 649639000275 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 649639000276 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 649639000277 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 649639000278 Ligand Binding Site [chemical binding]; other site 649639000279 TilS substrate C-terminal domain; Region: TilS_C; smart00977 649639000280 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 649639000281 active site 649639000282 FtsH Extracellular; Region: FtsH_ext; pfam06480 649639000283 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 649639000284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639000285 Walker A motif; other site 649639000286 ATP binding site [chemical binding]; other site 649639000287 Walker B motif; other site 649639000288 arginine finger; other site 649639000289 Peptidase family M41; Region: Peptidase_M41; pfam01434 649639000290 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 649639000291 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 649639000292 dimerization interface [polypeptide binding]; other site 649639000293 domain crossover interface; other site 649639000294 redox-dependent activation switch; other site 649639000295 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 649639000296 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 649639000297 dimer interface [polypeptide binding]; other site 649639000298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639000299 catalytic residue [active] 649639000300 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 649639000301 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 649639000302 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 649639000303 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 649639000304 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 649639000305 glutamine binding [chemical binding]; other site 649639000306 catalytic triad [active] 649639000307 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 649639000308 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 649639000309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639000310 catalytic residue [active] 649639000311 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 649639000312 dihydropteroate synthase; Region: DHPS; TIGR01496 649639000313 substrate binding pocket [chemical binding]; other site 649639000314 dimer interface [polypeptide binding]; other site 649639000315 inhibitor binding site; inhibition site 649639000316 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 649639000317 homooctamer interface [polypeptide binding]; other site 649639000318 active site 649639000319 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 649639000320 catalytic center binding site [active] 649639000321 ATP binding site [chemical binding]; other site 649639000322 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649639000323 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649639000324 non-specific DNA binding site [nucleotide binding]; other site 649639000325 salt bridge; other site 649639000326 sequence-specific DNA binding site [nucleotide binding]; other site 649639000327 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 649639000328 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 649639000329 FMN binding site [chemical binding]; other site 649639000330 active site 649639000331 catalytic residues [active] 649639000332 substrate binding site [chemical binding]; other site 649639000333 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 649639000334 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 649639000335 dimer interface [polypeptide binding]; other site 649639000336 putative anticodon binding site; other site 649639000337 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 649639000338 motif 1; other site 649639000339 active site 649639000340 motif 2; other site 649639000341 motif 3; other site 649639000342 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 649639000343 MgtC family; Region: MgtC; pfam02308 649639000344 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 649639000345 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 649639000346 UvrB/uvrC motif; Region: UVR; pfam02151 649639000347 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 649639000348 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 649639000349 ADP binding site [chemical binding]; other site 649639000350 phosphagen binding site; other site 649639000351 substrate specificity loop; other site 649639000352 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 649639000353 Clp amino terminal domain; Region: Clp_N; pfam02861 649639000354 Clp amino terminal domain; Region: Clp_N; pfam02861 649639000355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639000356 Walker A motif; other site 649639000357 ATP binding site [chemical binding]; other site 649639000358 Walker B motif; other site 649639000359 arginine finger; other site 649639000360 UvrB/uvrC motif; Region: UVR; pfam02151 649639000361 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639000362 Walker A motif; other site 649639000363 ATP binding site [chemical binding]; other site 649639000364 Walker B motif; other site 649639000365 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 649639000366 DNA repair protein RadA; Provisional; Region: PRK11823 649639000367 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 649639000368 Walker A motif/ATP binding site; other site 649639000369 ATP binding site [chemical binding]; other site 649639000370 Walker B motif; other site 649639000371 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 649639000372 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 649639000373 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 649639000374 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 649639000375 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 649639000376 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 649639000377 putative active site [active] 649639000378 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 649639000379 substrate binding site; other site 649639000380 dimer interface; other site 649639000381 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 649639000382 homotrimer interaction site [polypeptide binding]; other site 649639000383 zinc binding site [ion binding]; other site 649639000384 CDP-binding sites; other site 649639000385 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 649639000386 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 649639000387 active site 649639000388 HIGH motif; other site 649639000389 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 649639000390 active site 649639000391 KMSKS motif; other site 649639000392 serine O-acetyltransferase; Region: cysE; TIGR01172 649639000393 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 649639000394 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 649639000395 trimer interface [polypeptide binding]; other site 649639000396 active site 649639000397 substrate binding site [chemical binding]; other site 649639000398 CoA binding site [chemical binding]; other site 649639000399 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 649639000400 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 649639000401 active site 649639000402 HIGH motif; other site 649639000403 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 649639000404 KMSKS motif; other site 649639000405 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 649639000406 tRNA binding surface [nucleotide binding]; other site 649639000407 anticodon binding site; other site 649639000408 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 649639000409 active site 649639000410 metal binding site [ion binding]; metal-binding site 649639000411 dimerization interface [polypeptide binding]; other site 649639000412 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 649639000413 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 649639000414 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 649639000415 YacP-like NYN domain; Region: NYN_YacP; cl01491 649639000416 RNA polymerase factor sigma-70; Validated; Region: PRK08295 649639000417 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639000418 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 649639000419 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 649639000420 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 649639000421 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 649639000422 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 649639000423 putative homodimer interface [polypeptide binding]; other site 649639000424 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 649639000425 heterodimer interface [polypeptide binding]; other site 649639000426 homodimer interface [polypeptide binding]; other site 649639000427 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 649639000428 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 649639000429 23S rRNA interface [nucleotide binding]; other site 649639000430 L7/L12 interface [polypeptide binding]; other site 649639000431 putative thiostrepton binding site; other site 649639000432 L25 interface [polypeptide binding]; other site 649639000433 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 649639000434 mRNA/rRNA interface [nucleotide binding]; other site 649639000435 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 649639000436 23S rRNA interface [nucleotide binding]; other site 649639000437 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 649639000438 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 649639000439 core dimer interface [polypeptide binding]; other site 649639000440 peripheral dimer interface [polypeptide binding]; other site 649639000441 L10 interface [polypeptide binding]; other site 649639000442 L11 interface [polypeptide binding]; other site 649639000443 putative EF-Tu interaction site [polypeptide binding]; other site 649639000444 putative EF-G interaction site [polypeptide binding]; other site 649639000445 Methyltransferase domain; Region: Methyltransf_31; pfam13847 649639000446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639000447 S-adenosylmethionine binding site [chemical binding]; other site 649639000448 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 649639000449 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 649639000450 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 649639000451 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 649639000452 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 649639000453 RPB10 interaction site [polypeptide binding]; other site 649639000454 RPB1 interaction site [polypeptide binding]; other site 649639000455 RPB11 interaction site [polypeptide binding]; other site 649639000456 RPB3 interaction site [polypeptide binding]; other site 649639000457 RPB12 interaction site [polypeptide binding]; other site 649639000458 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 649639000459 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 649639000460 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 649639000461 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 649639000462 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 649639000463 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 649639000464 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 649639000465 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 649639000466 G-loop; other site 649639000467 DNA binding site [nucleotide binding] 649639000468 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 649639000469 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 649639000470 S17 interaction site [polypeptide binding]; other site 649639000471 S8 interaction site; other site 649639000472 16S rRNA interaction site [nucleotide binding]; other site 649639000473 streptomycin interaction site [chemical binding]; other site 649639000474 23S rRNA interaction site [nucleotide binding]; other site 649639000475 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 649639000476 30S ribosomal protein S7; Validated; Region: PRK05302 649639000477 elongation factor G; Reviewed; Region: PRK00007 649639000478 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 649639000479 G1 box; other site 649639000480 putative GEF interaction site [polypeptide binding]; other site 649639000481 GTP/Mg2+ binding site [chemical binding]; other site 649639000482 Switch I region; other site 649639000483 G2 box; other site 649639000484 G3 box; other site 649639000485 Switch II region; other site 649639000486 G4 box; other site 649639000487 G5 box; other site 649639000488 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 649639000489 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 649639000490 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 649639000491 elongation factor Tu; Reviewed; Region: PRK00049 649639000492 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 649639000493 G1 box; other site 649639000494 GEF interaction site [polypeptide binding]; other site 649639000495 GTP/Mg2+ binding site [chemical binding]; other site 649639000496 Switch I region; other site 649639000497 G2 box; other site 649639000498 G3 box; other site 649639000499 Switch II region; other site 649639000500 G4 box; other site 649639000501 G5 box; other site 649639000502 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 649639000503 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 649639000504 Antibiotic Binding Site [chemical binding]; other site 649639000505 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 649639000506 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 649639000507 Walker A/P-loop; other site 649639000508 ATP binding site [chemical binding]; other site 649639000509 Q-loop/lid; other site 649639000510 ABC transporter signature motif; other site 649639000511 Walker B; other site 649639000512 D-loop; other site 649639000513 H-loop/switch region; other site 649639000514 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 649639000515 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 649639000516 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 649639000517 Walker A/P-loop; other site 649639000518 ATP binding site [chemical binding]; other site 649639000519 Q-loop/lid; other site 649639000520 ABC transporter signature motif; other site 649639000521 Walker B; other site 649639000522 D-loop; other site 649639000523 H-loop/switch region; other site 649639000524 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 649639000525 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 649639000526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639000527 dimer interface [polypeptide binding]; other site 649639000528 conserved gate region; other site 649639000529 putative PBP binding loops; other site 649639000530 ABC-ATPase subunit interface; other site 649639000531 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 649639000532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639000533 dimer interface [polypeptide binding]; other site 649639000534 conserved gate region; other site 649639000535 ABC-ATPase subunit interface; other site 649639000536 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 649639000537 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 649639000538 peptide binding site [polypeptide binding]; other site 649639000539 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 649639000540 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 649639000541 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 649639000542 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 649639000543 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 649639000544 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 649639000545 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 649639000546 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 649639000547 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 649639000548 putative translocon binding site; other site 649639000549 protein-rRNA interface [nucleotide binding]; other site 649639000550 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 649639000551 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 649639000552 G-X-X-G motif; other site 649639000553 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 649639000554 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 649639000555 23S rRNA interface [nucleotide binding]; other site 649639000556 5S rRNA interface [nucleotide binding]; other site 649639000557 putative antibiotic binding site [chemical binding]; other site 649639000558 L25 interface [polypeptide binding]; other site 649639000559 L27 interface [polypeptide binding]; other site 649639000560 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 649639000561 23S rRNA interface [nucleotide binding]; other site 649639000562 putative translocon interaction site; other site 649639000563 signal recognition particle (SRP54) interaction site; other site 649639000564 L23 interface [polypeptide binding]; other site 649639000565 trigger factor interaction site; other site 649639000566 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 649639000567 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 649639000568 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 649639000569 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 649639000570 RNA binding site [nucleotide binding]; other site 649639000571 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 649639000572 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 649639000573 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 649639000574 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 649639000575 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 649639000576 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 649639000577 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 649639000578 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 649639000579 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 649639000580 5S rRNA interface [nucleotide binding]; other site 649639000581 L27 interface [polypeptide binding]; other site 649639000582 23S rRNA interface [nucleotide binding]; other site 649639000583 L5 interface [polypeptide binding]; other site 649639000584 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 649639000585 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 649639000586 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 649639000587 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 649639000588 23S rRNA binding site [nucleotide binding]; other site 649639000589 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 649639000590 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 649639000591 SecY translocase; Region: SecY; pfam00344 649639000592 adenylate kinase; Reviewed; Region: adk; PRK00279 649639000593 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 649639000594 AMP-binding site [chemical binding]; other site 649639000595 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 649639000596 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 649639000597 active site 649639000598 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 649639000599 RNA binding site [nucleotide binding]; other site 649639000600 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 649639000601 rRNA binding site [nucleotide binding]; other site 649639000602 predicted 30S ribosome binding site; other site 649639000603 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 649639000604 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 649639000605 30S ribosomal protein S13; Region: bact_S13; TIGR03631 649639000606 30S ribosomal protein S11; Validated; Region: PRK05309 649639000607 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 649639000608 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 649639000609 alphaNTD homodimer interface [polypeptide binding]; other site 649639000610 alphaNTD - beta interaction site [polypeptide binding]; other site 649639000611 alphaNTD - beta' interaction site [polypeptide binding]; other site 649639000612 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 649639000613 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 649639000614 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 649639000615 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 649639000616 Walker A/P-loop; other site 649639000617 ATP binding site [chemical binding]; other site 649639000618 Q-loop/lid; other site 649639000619 ABC transporter signature motif; other site 649639000620 Walker B; other site 649639000621 D-loop; other site 649639000622 H-loop/switch region; other site 649639000623 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 649639000624 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 649639000625 Walker A/P-loop; other site 649639000626 ATP binding site [chemical binding]; other site 649639000627 Q-loop/lid; other site 649639000628 ABC transporter signature motif; other site 649639000629 Walker B; other site 649639000630 D-loop; other site 649639000631 H-loop/switch region; other site 649639000632 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 649639000633 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 649639000634 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 649639000635 dimerization interface 3.5A [polypeptide binding]; other site 649639000636 active site 649639000637 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 649639000638 23S rRNA interface [nucleotide binding]; other site 649639000639 L3 interface [polypeptide binding]; other site 649639000640 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 649639000641 TraX protein; Region: TraX; cl05434 649639000642 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 649639000643 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 649639000644 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 649639000645 active site 649639000646 metal binding site [ion binding]; metal-binding site 649639000647 Domain of unknown function DUF59; Region: DUF59; pfam01883 649639000648 antiporter inner membrane protein; Provisional; Region: PRK11670 649639000649 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 649639000650 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 649639000651 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 649639000652 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 649639000653 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 649639000654 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 649639000655 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639000656 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649639000657 DNA binding residues [nucleotide binding] 649639000658 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 649639000659 Putative zinc-finger; Region: zf-HC2; pfam13490 649639000660 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 649639000661 Uncharacterized conserved protein [Function unknown]; Region: COG1624 649639000662 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 649639000663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 649639000664 YbbR-like protein; Region: YbbR; pfam07949 649639000665 YbbR-like protein; Region: YbbR; pfam07949 649639000666 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 649639000667 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 649639000668 active site 649639000669 substrate binding site [chemical binding]; other site 649639000670 metal binding site [ion binding]; metal-binding site 649639000671 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 649639000672 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 649639000673 glutaminase active site [active] 649639000674 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 649639000675 dimer interface [polypeptide binding]; other site 649639000676 active site 649639000677 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 649639000678 dimer interface [polypeptide binding]; other site 649639000679 active site 649639000680 Uncharacterized conserved protein [Function unknown]; Region: COG4748 649639000681 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 649639000682 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 649639000683 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 649639000684 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 649639000685 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 649639000686 active site 649639000687 DNA binding site [nucleotide binding] 649639000688 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 649639000689 DNA binding site [nucleotide binding] 649639000690 bile acid transporter; Region: bass; TIGR00841 649639000691 Sodium Bile acid symporter family; Region: SBF; cl17470 649639000692 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 649639000693 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 649639000694 metal-binding site [ion binding] 649639000695 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 649639000696 Soluble P-type ATPase [General function prediction only]; Region: COG4087 649639000697 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649639000698 dimerization interface [polypeptide binding]; other site 649639000699 putative DNA binding site [nucleotide binding]; other site 649639000700 putative Zn2+ binding site [ion binding]; other site 649639000701 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649639000702 non-specific DNA binding site [nucleotide binding]; other site 649639000703 salt bridge; other site 649639000704 sequence-specific DNA binding site [nucleotide binding]; other site 649639000705 Domain of unknown function (DUF955); Region: DUF955; cl01076 649639000706 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 649639000707 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 649639000708 DNA binding residues [nucleotide binding] 649639000709 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 649639000710 non-specific DNA binding site [nucleotide binding]; other site 649639000711 salt bridge; other site 649639000712 sequence-specific DNA binding site [nucleotide binding]; other site 649639000713 AlwI restriction endonuclease; Region: RE_AlwI; pfam09491 649639000714 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 649639000715 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 649639000716 cofactor binding site; other site 649639000717 DNA binding site [nucleotide binding] 649639000718 substrate interaction site [chemical binding]; other site 649639000719 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 649639000720 Mg binding site [ion binding]; other site 649639000721 nucleotide binding site [chemical binding]; other site 649639000722 putative protofilament interface [polypeptide binding]; other site 649639000723 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 649639000724 DEAD-like helicases superfamily; Region: DEXDc; smart00487 649639000725 four helix bundle protein; Region: TIGR02436 649639000726 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 649639000727 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 649639000728 four helix bundle protein; Region: TIGR02436 649639000729 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 649639000730 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 649639000731 active site 649639000732 DNA binding site [nucleotide binding] 649639000733 Int/Topo IB signature motif; other site 649639000734 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 649639000735 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 649639000736 Integrase core domain; Region: rve; pfam00665 649639000737 AAA ATPase domain; Region: AAA_16; pfam13191 649639000738 AAA domain; Region: AAA_22; pfam13401 649639000739 Bacterial TniB protein; Region: TniB; pfam05621 649639000740 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 649639000741 Helix-turn-helix domain; Region: HTH_38; pfam13936 649639000742 Domain of unknown function (DUF771); Region: DUF771; cl09962 649639000743 AAA domain; Region: AAA_13; pfam13166 649639000744 Putative catalytic domain of uncharacterized hypothetical proteins closely related to Nuc, , an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar2; cd09174 649639000745 PLD-like domain; Region: PLDc_2; pfam13091 649639000746 putative active site [active] 649639000747 catalytic site [active] 649639000748 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 649639000749 active site 649639000750 NTP binding site [chemical binding]; other site 649639000751 metal binding triad [ion binding]; metal-binding site 649639000752 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 649639000753 nudix motif; other site 649639000754 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 649639000755 catalytic core [active] 649639000756 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 649639000757 NodB motif; other site 649639000758 active site 649639000759 catalytic site [active] 649639000760 metal binding site [ion binding]; metal-binding site 649639000761 Predicted transcriptional regulators [Transcription]; Region: COG1725 649639000762 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649639000763 DNA-binding site [nucleotide binding]; DNA binding site 649639000764 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649639000765 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 649639000766 Walker A/P-loop; other site 649639000767 ATP binding site [chemical binding]; other site 649639000768 Q-loop/lid; other site 649639000769 ABC transporter signature motif; other site 649639000770 Walker B; other site 649639000771 D-loop; other site 649639000772 H-loop/switch region; other site 649639000773 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 649639000774 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 649639000775 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 649639000776 Methyltransferase domain; Region: Methyltransf_31; pfam13847 649639000777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639000778 S-adenosylmethionine binding site [chemical binding]; other site 649639000779 Transcriptional regulator [Transcription]; Region: LysR; COG0583 649639000780 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649639000781 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 649639000782 putative dimerization interface [polypeptide binding]; other site 649639000783 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 649639000784 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 649639000785 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649639000786 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 649639000787 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 649639000788 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 649639000789 [2Fe-2S] cluster binding site [ion binding]; other site 649639000790 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 649639000791 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 649639000792 active site 649639000793 SAM binding site [chemical binding]; other site 649639000794 homodimer interface [polypeptide binding]; other site 649639000795 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 649639000796 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649639000797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 649639000798 phosphorylation site [posttranslational modification] 649639000799 intermolecular recognition site; other site 649639000800 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649639000801 DNA binding residues [nucleotide binding] 649639000802 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 649639000803 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649639000804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639000805 Walker A/P-loop; other site 649639000806 ATP binding site [chemical binding]; other site 649639000807 Q-loop/lid; other site 649639000808 ABC transporter signature motif; other site 649639000809 Walker B; other site 649639000810 D-loop; other site 649639000811 H-loop/switch region; other site 649639000812 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 649639000813 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649639000814 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 649639000815 Walker A/P-loop; other site 649639000816 ATP binding site [chemical binding]; other site 649639000817 Q-loop/lid; other site 649639000818 ABC transporter signature motif; other site 649639000819 Walker B; other site 649639000820 D-loop; other site 649639000821 H-loop/switch region; other site 649639000822 Nuclease-related domain; Region: NERD; pfam08378 649639000823 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 649639000824 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 649639000825 YpzG-like protein; Region: YpzG; pfam14139 649639000826 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 649639000827 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639000828 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649639000829 DNA binding residues [nucleotide binding] 649639000830 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 649639000831 active site 649639000832 metal binding site [ion binding]; metal-binding site 649639000833 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 649639000834 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 649639000835 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 649639000836 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649639000837 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649639000838 dimerization interface [polypeptide binding]; other site 649639000839 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639000840 dimer interface [polypeptide binding]; other site 649639000841 phosphorylation site [posttranslational modification] 649639000842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639000843 ATP binding site [chemical binding]; other site 649639000844 Mg2+ binding site [ion binding]; other site 649639000845 G-X-G motif; other site 649639000846 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649639000847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639000848 active site 649639000849 phosphorylation site [posttranslational modification] 649639000850 intermolecular recognition site; other site 649639000851 dimerization interface [polypeptide binding]; other site 649639000852 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649639000853 DNA binding site [nucleotide binding] 649639000854 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 649639000855 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 649639000856 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 649639000857 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 649639000858 catalytic residues [active] 649639000859 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 649639000860 catalytic residues [active] 649639000861 dimer interface [polypeptide binding]; other site 649639000862 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 649639000863 Domain of unknown function DUF21; Region: DUF21; pfam01595 649639000864 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 649639000865 Transporter associated domain; Region: CorC_HlyC; smart01091 649639000866 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 649639000867 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 649639000868 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649639000869 dimerization interface [polypeptide binding]; other site 649639000870 putative DNA binding site [nucleotide binding]; other site 649639000871 putative Zn2+ binding site [ion binding]; other site 649639000872 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 649639000873 Sodium Bile acid symporter family; Region: SBF; cl17470 649639000874 Low molecular weight phosphatase family; Region: LMWPc; cd00115 649639000875 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 649639000876 active site 649639000877 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 649639000878 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 649639000879 Sodium Bile acid symporter family; Region: SBF; cl17470 649639000880 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 649639000881 dimerization interface [polypeptide binding]; other site 649639000882 putative active cleft [active] 649639000883 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 649639000884 active site 649639000885 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 649639000886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639000887 Coenzyme A binding pocket [chemical binding]; other site 649639000888 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 649639000889 dimanganese center [ion binding]; other site 649639000890 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 649639000891 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 649639000892 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 649639000893 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 649639000894 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 649639000895 beta-galactosidase; Region: BGL; TIGR03356 649639000896 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 649639000897 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 649639000898 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 649639000899 dimerization interface [polypeptide binding]; other site 649639000900 DPS ferroxidase diiron center [ion binding]; other site 649639000901 ion pore; other site 649639000902 CHASE4 domain; Region: CHASE4; pfam05228 649639000903 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649639000904 dimerization interface [polypeptide binding]; other site 649639000905 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649639000906 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649639000907 metal binding site [ion binding]; metal-binding site 649639000908 active site 649639000909 I-site; other site 649639000910 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649639000911 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 649639000912 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 649639000913 nucleotide binding site [chemical binding]; other site 649639000914 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649639000915 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 649639000916 MarR family; Region: MarR_2; cl17246 649639000917 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 649639000918 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 649639000919 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649639000920 Ligand Binding Site [chemical binding]; other site 649639000921 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 649639000922 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 649639000923 Sulfate transporter family; Region: Sulfate_transp; pfam00916 649639000924 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 649639000925 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 649639000926 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 649639000927 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 649639000928 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 649639000929 substrate binding site [chemical binding]; other site 649639000930 dimer interface [polypeptide binding]; other site 649639000931 ATP binding site [chemical binding]; other site 649639000932 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 649639000933 DNA-binding site [nucleotide binding]; DNA binding site 649639000934 RNA-binding motif; other site 649639000935 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 649639000936 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 649639000937 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 649639000938 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 649639000939 YqxM protein; Region: YqxM_for_SipW; TIGR04087 649639000940 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 649639000941 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 649639000942 Catalytic site [active] 649639000943 BCCT family transporter; Region: BCCT; pfam02028 649639000944 Predicted flavoprotein [General function prediction only]; Region: COG0431 649639000945 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 649639000946 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 649639000947 dimer interface [polypeptide binding]; other site 649639000948 putative tRNA-binding site [nucleotide binding]; other site 649639000949 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 649639000950 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 649639000951 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 649639000952 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 649639000953 active site 649639000954 HIGH motif; other site 649639000955 KMSK motif region; other site 649639000956 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 649639000957 tRNA binding surface [nucleotide binding]; other site 649639000958 anticodon binding site; other site 649639000959 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 649639000960 active site residue [active] 649639000961 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 649639000962 active site residue [active] 649639000963 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 649639000964 putative homodimer interface [polypeptide binding]; other site 649639000965 putative homotetramer interface [polypeptide binding]; other site 649639000966 putative metal binding site [ion binding]; other site 649639000967 putative homodimer-homodimer interface [polypeptide binding]; other site 649639000968 putative allosteric switch controlling residues; other site 649639000969 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 649639000970 active site residue [active] 649639000971 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649639000972 dimerization interface [polypeptide binding]; other site 649639000973 putative DNA binding site [nucleotide binding]; other site 649639000974 putative Zn2+ binding site [ion binding]; other site 649639000975 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 649639000976 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 649639000977 metal-binding site [ion binding] 649639000978 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 649639000979 Soluble P-type ATPase [General function prediction only]; Region: COG4087 649639000980 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 649639000981 Sporulation and spore germination; Region: Germane; pfam10646 649639000982 Uncharacterized conserved protein [Function unknown]; Region: COG3595 649639000983 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 649639000984 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 649639000985 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 649639000986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639000987 dimer interface [polypeptide binding]; other site 649639000988 conserved gate region; other site 649639000989 putative PBP binding loops; other site 649639000990 ABC-ATPase subunit interface; other site 649639000991 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 649639000992 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 649639000993 Walker A/P-loop; other site 649639000994 ATP binding site [chemical binding]; other site 649639000995 Q-loop/lid; other site 649639000996 ABC transporter signature motif; other site 649639000997 Walker B; other site 649639000998 D-loop; other site 649639000999 H-loop/switch region; other site 649639001000 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 649639001001 Predicted transcriptional regulators [Transcription]; Region: COG1510 649639001002 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 649639001003 putative DNA binding site [nucleotide binding]; other site 649639001004 putative Zn2+ binding site [ion binding]; other site 649639001005 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 649639001006 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639001007 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649639001008 DNA binding residues [nucleotide binding] 649639001009 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 649639001010 MgtE intracellular N domain; Region: MgtE_N; smart00924 649639001011 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 649639001012 Divalent cation transporter; Region: MgtE; pfam01769 649639001013 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 649639001014 D-pathway; other site 649639001015 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 649639001016 Low-spin heme binding site [chemical binding]; other site 649639001017 Putative water exit pathway; other site 649639001018 Binuclear center (active site) [active] 649639001019 K-pathway; other site 649639001020 Putative proton exit pathway; other site 649639001021 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 649639001022 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 649639001023 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 649639001024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639001025 Walker A/P-loop; other site 649639001026 ATP binding site [chemical binding]; other site 649639001027 Q-loop/lid; other site 649639001028 ABC transporter signature motif; other site 649639001029 Walker B; other site 649639001030 D-loop; other site 649639001031 H-loop/switch region; other site 649639001032 TOBE domain; Region: TOBE_2; pfam08402 649639001033 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 649639001034 Uncharacterized conserved protein [Function unknown]; Region: COG2461 649639001035 Family of unknown function (DUF438); Region: DUF438; pfam04282 649639001036 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 649639001037 Rhomboid family; Region: Rhomboid; pfam01694 649639001038 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 649639001039 putative carbohydrate kinase; Provisional; Region: PRK10565 649639001040 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 649639001041 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 649639001042 putative substrate binding site [chemical binding]; other site 649639001043 putative ATP binding site [chemical binding]; other site 649639001044 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 649639001045 alanine racemase; Reviewed; Region: alr; PRK00053 649639001046 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 649639001047 active site 649639001048 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 649639001049 dimer interface [polypeptide binding]; other site 649639001050 substrate binding site [chemical binding]; other site 649639001051 catalytic residues [active] 649639001052 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 649639001053 PemK-like protein; Region: PemK; pfam02452 649639001054 Rsbr N terminal; Region: Rsbr_N; pfam08678 649639001055 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 649639001056 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 649639001057 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 649639001058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639001059 ATP binding site [chemical binding]; other site 649639001060 Mg2+ binding site [ion binding]; other site 649639001061 G-X-G motif; other site 649639001062 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 649639001063 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 649639001064 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 649639001065 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649639001066 anti sigma factor interaction site; other site 649639001067 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 649639001068 regulatory phosphorylation site [posttranslational modification]; other site 649639001069 serine-protein kinase RsbW; Provisional; Region: PRK04069 649639001070 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 649639001071 ATP binding site [chemical binding]; other site 649639001072 Mg2+ binding site [ion binding]; other site 649639001073 G-X-G motif; other site 649639001074 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 649639001075 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639001076 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 649639001077 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649639001078 DNA binding residues [nucleotide binding] 649639001079 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 649639001080 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 649639001081 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 649639001082 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 649639001083 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 649639001084 RNA binding site [nucleotide binding]; other site 649639001085 hypothetical protein; Provisional; Region: PRK04351 649639001086 SprT homologues; Region: SprT; cl01182 649639001087 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 649639001088 HAMP domain; Region: HAMP; pfam00672 649639001089 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649639001090 dimer interface [polypeptide binding]; other site 649639001091 putative CheW interface [polypeptide binding]; other site 649639001092 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 649639001093 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 649639001094 homodimer interface [polypeptide binding]; other site 649639001095 substrate-cofactor binding pocket; other site 649639001096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639001097 catalytic residue [active] 649639001098 thiamine monophosphate kinase; Provisional; Region: PRK05731 649639001099 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 649639001100 ATP binding site [chemical binding]; other site 649639001101 dimerization interface [polypeptide binding]; other site 649639001102 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 649639001103 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 649639001104 Glycoprotease family; Region: Peptidase_M22; pfam00814 649639001105 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 649639001106 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639001107 Coenzyme A binding pocket [chemical binding]; other site 649639001108 UGMP family protein; Validated; Region: PRK09604 649639001109 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 649639001110 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 649639001111 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 649639001112 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 649639001113 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649639001114 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649639001115 ABC transporter; Region: ABC_tran_2; pfam12848 649639001116 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649639001117 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 649639001118 trimer interface [polypeptide binding]; other site 649639001119 dimer interface [polypeptide binding]; other site 649639001120 putative active site [active] 649639001121 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 649639001122 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 649639001123 CoA binding domain; Region: CoA_binding; pfam02629 649639001124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639001125 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649639001126 putative substrate translocation pore; other site 649639001127 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 649639001128 CAAX protease self-immunity; Region: Abi; pfam02517 649639001129 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 649639001130 oligomerisation interface [polypeptide binding]; other site 649639001131 mobile loop; other site 649639001132 roof hairpin; other site 649639001133 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 649639001134 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 649639001135 ring oligomerisation interface [polypeptide binding]; other site 649639001136 ATP/Mg binding site [chemical binding]; other site 649639001137 stacking interactions; other site 649639001138 hinge regions; other site 649639001139 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 649639001140 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 649639001141 DNA interaction; other site 649639001142 Metal-binding active site; metal-binding site 649639001143 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649639001144 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649639001145 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 649639001146 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_7; cd06316 649639001147 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 649639001148 putative ligand binding site [chemical binding]; other site 649639001149 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649639001150 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649639001151 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 649639001152 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 649639001153 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 649639001154 Walker A/P-loop; other site 649639001155 ATP binding site [chemical binding]; other site 649639001156 Q-loop/lid; other site 649639001157 ABC transporter signature motif; other site 649639001158 Walker B; other site 649639001159 D-loop; other site 649639001160 H-loop/switch region; other site 649639001161 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 649639001162 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 649639001163 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 649639001164 TM-ABC transporter signature motif; other site 649639001165 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 649639001166 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 649639001167 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649639001168 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649639001169 DNA binding site [nucleotide binding] 649639001170 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649639001171 ligand binding site [chemical binding]; other site 649639001172 dimerization interface [polypeptide binding]; other site 649639001173 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 649639001174 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 649639001175 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649639001176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649639001177 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 649639001178 substrate binding site [chemical binding]; other site 649639001179 active site 649639001180 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 649639001181 ligand binding site [chemical binding]; other site 649639001182 RDD family; Region: RDD; pfam06271 649639001183 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649639001184 MarR family; Region: MarR_2; pfam12802 649639001185 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649639001186 MarR family; Region: MarR; pfam01047 649639001187 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 649639001188 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 649639001189 ABC-ATPase subunit interface; other site 649639001190 dimer interface [polypeptide binding]; other site 649639001191 putative PBP binding regions; other site 649639001192 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 649639001193 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 649639001194 ABC-ATPase subunit interface; other site 649639001195 dimer interface [polypeptide binding]; other site 649639001196 putative PBP binding regions; other site 649639001197 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 649639001198 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 649639001199 Walker A/P-loop; other site 649639001200 ATP binding site [chemical binding]; other site 649639001201 Q-loop/lid; other site 649639001202 ABC transporter signature motif; other site 649639001203 Walker B; other site 649639001204 D-loop; other site 649639001205 H-loop/switch region; other site 649639001206 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 649639001207 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 649639001208 putative ligand binding residues [chemical binding]; other site 649639001209 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 649639001210 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cd10546 649639001211 putative active site [active] 649639001212 redox center [active] 649639001213 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 649639001214 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649639001215 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649639001216 dimer interface [polypeptide binding]; other site 649639001217 putative CheW interface [polypeptide binding]; other site 649639001218 MoxR-like ATPases [General function prediction only]; Region: COG0714 649639001219 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639001220 Walker A motif; other site 649639001221 ATP binding site [chemical binding]; other site 649639001222 Walker B motif; other site 649639001223 arginine finger; other site 649639001224 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 649639001225 Protein of unknown function DUF58; Region: DUF58; pfam01882 649639001226 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 649639001227 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 649639001228 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 649639001229 GMP synthase; Reviewed; Region: guaA; PRK00074 649639001230 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 649639001231 AMP/PPi binding site [chemical binding]; other site 649639001232 candidate oxyanion hole; other site 649639001233 catalytic triad [active] 649639001234 potential glutamine specificity residues [chemical binding]; other site 649639001235 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 649639001236 ATP Binding subdomain [chemical binding]; other site 649639001237 Ligand Binding sites [chemical binding]; other site 649639001238 Dimerization subdomain; other site 649639001239 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 649639001240 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 649639001241 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 649639001242 malonyl-CoA binding site [chemical binding]; other site 649639001243 dimer interface [polypeptide binding]; other site 649639001244 active site 649639001245 product binding site; other site 649639001246 Phospholipid methyltransferase; Region: PEMT; cl17370 649639001247 NETI protein; Region: NETI; pfam14044 649639001248 Coat F domain; Region: Coat_F; pfam07875 649639001249 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 649639001250 amidase; Provisional; Region: PRK06828 649639001251 Amidase; Region: Amidase; pfam01425 649639001252 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 649639001253 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 649639001254 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 649639001255 ATP-grasp domain; Region: ATP-grasp; pfam02222 649639001256 adenylosuccinate lyase; Provisional; Region: PRK07492 649639001257 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 649639001258 tetramer interface [polypeptide binding]; other site 649639001259 active site 649639001260 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 649639001261 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 649639001262 ATP binding site [chemical binding]; other site 649639001263 active site 649639001264 substrate binding site [chemical binding]; other site 649639001265 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 649639001266 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 649639001267 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 649639001268 putative active site [active] 649639001269 catalytic triad [active] 649639001270 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 649639001271 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 649639001272 dimerization interface [polypeptide binding]; other site 649639001273 ATP binding site [chemical binding]; other site 649639001274 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 649639001275 dimerization interface [polypeptide binding]; other site 649639001276 ATP binding site [chemical binding]; other site 649639001277 amidophosphoribosyltransferase; Provisional; Region: PRK07631 649639001278 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 649639001279 active site 649639001280 tetramer interface [polypeptide binding]; other site 649639001281 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 649639001282 active site 649639001283 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 649639001284 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 649639001285 dimerization interface [polypeptide binding]; other site 649639001286 putative ATP binding site [chemical binding]; other site 649639001287 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 649639001288 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 649639001289 active site 649639001290 substrate binding site [chemical binding]; other site 649639001291 cosubstrate binding site; other site 649639001292 catalytic site [active] 649639001293 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 649639001294 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 649639001295 purine monophosphate binding site [chemical binding]; other site 649639001296 dimer interface [polypeptide binding]; other site 649639001297 putative catalytic residues [active] 649639001298 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 649639001299 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 649639001300 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 649639001301 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 649639001302 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 649639001303 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 649639001304 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 649639001305 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 649639001306 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649639001307 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649639001308 active site 649639001309 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 649639001310 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 649639001311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 649639001312 PcrB family; Region: PcrB; pfam01884 649639001313 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 649639001314 substrate binding site [chemical binding]; other site 649639001315 putative active site [active] 649639001316 dimer interface [polypeptide binding]; other site 649639001317 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 649639001318 Part of AAA domain; Region: AAA_19; pfam13245 649639001319 Family description; Region: UvrD_C_2; pfam13538 649639001320 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 649639001321 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 649639001322 nucleotide binding pocket [chemical binding]; other site 649639001323 K-X-D-G motif; other site 649639001324 catalytic site [active] 649639001325 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 649639001326 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 649639001327 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 649639001328 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 649639001329 Dimer interface [polypeptide binding]; other site 649639001330 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 649639001331 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 649639001332 putative dimer interface [polypeptide binding]; other site 649639001333 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 649639001334 putative dimer interface [polypeptide binding]; other site 649639001335 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 649639001336 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 649639001337 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 649639001338 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 649639001339 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 649639001340 GatB domain; Region: GatB_Yqey; smart00845 649639001341 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 649639001342 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 649639001343 aromatic chitin/cellulose binding site residues [chemical binding]; other site 649639001344 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 649639001345 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 649639001346 aromatic chitin/cellulose binding site residues [chemical binding]; other site 649639001347 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 649639001348 aromatic chitin/cellulose binding site residues [chemical binding]; other site 649639001349 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 649639001350 Amidinotransferase; Region: Amidinotransf; pfam02274 649639001351 putative lipid kinase; Reviewed; Region: PRK13337 649639001352 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 649639001353 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649639001354 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639001355 Walker A/P-loop; other site 649639001356 ATP binding site [chemical binding]; other site 649639001357 Q-loop/lid; other site 649639001358 ABC transporter signature motif; other site 649639001359 Walker B; other site 649639001360 D-loop; other site 649639001361 H-loop/switch region; other site 649639001362 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 649639001363 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 649639001364 Predicted membrane protein [Function unknown]; Region: COG2311 649639001365 Protein of unknown function (DUF418); Region: DUF418; cl12135 649639001366 Protein of unknown function (DUF418); Region: DUF418; pfam04235 649639001367 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 649639001368 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 649639001369 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639001370 motif II; other site 649639001371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639001372 Coenzyme A binding pocket [chemical binding]; other site 649639001373 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 649639001374 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 649639001375 Catalytic site [active] 649639001376 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 649639001377 HNH endonuclease; Region: HNH; pfam01844 649639001378 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 649639001379 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 649639001380 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 649639001381 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649639001382 DNA binding residues [nucleotide binding] 649639001383 Putative zinc-finger; Region: zf-HC2; pfam13490 649639001384 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 649639001385 SEC-C motif; Region: SEC-C; pfam02810 649639001386 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 649639001387 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 649639001388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639001389 S-adenosylmethionine binding site [chemical binding]; other site 649639001390 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649639001391 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649639001392 non-specific DNA binding site [nucleotide binding]; other site 649639001393 salt bridge; other site 649639001394 sequence-specific DNA binding site [nucleotide binding]; other site 649639001395 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 649639001396 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 649639001397 FMN binding site [chemical binding]; other site 649639001398 active site 649639001399 catalytic residues [active] 649639001400 substrate binding site [chemical binding]; other site 649639001401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639001402 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649639001403 putative substrate translocation pore; other site 649639001404 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 649639001405 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 649639001406 dimer interface [polypeptide binding]; other site 649639001407 active site 649639001408 heme binding site [chemical binding]; other site 649639001409 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 649639001410 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 649639001411 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 649639001412 putative ligand binding site [chemical binding]; other site 649639001413 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 649639001414 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 649639001415 Walker A/P-loop; other site 649639001416 ATP binding site [chemical binding]; other site 649639001417 Q-loop/lid; other site 649639001418 ABC transporter signature motif; other site 649639001419 Walker B; other site 649639001420 D-loop; other site 649639001421 H-loop/switch region; other site 649639001422 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 649639001423 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 649639001424 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 649639001425 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 649639001426 TM-ABC transporter signature motif; other site 649639001427 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 649639001428 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 649639001429 ligand binding site [chemical binding]; other site 649639001430 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649639001431 dimerization interface [polypeptide binding]; other site 649639001432 Histidine kinase; Region: His_kinase; pfam06580 649639001433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639001434 ATP binding site [chemical binding]; other site 649639001435 Mg2+ binding site [ion binding]; other site 649639001436 G-X-G motif; other site 649639001437 Response regulator receiver domain; Region: Response_reg; pfam00072 649639001438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639001439 active site 649639001440 phosphorylation site [posttranslational modification] 649639001441 intermolecular recognition site; other site 649639001442 dimerization interface [polypeptide binding]; other site 649639001443 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 649639001444 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649639001445 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 649639001446 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 649639001447 putative ligand binding site [chemical binding]; other site 649639001448 Divergent PAP2 family; Region: DUF212; pfam02681 649639001449 Uncharacterized conserved protein [Function unknown]; Region: COG0397 649639001450 hypothetical protein; Validated; Region: PRK00029 649639001451 Glycoside hydrolase family 94 N-terminal-like domain of NdvB-like proteins; Region: GH94N_NdvB_like; cd11748 649639001452 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 649639001453 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 649639001454 lipoprotein signal peptidase; Provisional; Region: PRK14787 649639001455 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 649639001456 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 649639001457 active site 649639001458 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 649639001459 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649639001460 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649639001461 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 649639001462 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649639001463 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649639001464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639001465 dimer interface [polypeptide binding]; other site 649639001466 conserved gate region; other site 649639001467 putative PBP binding loops; other site 649639001468 ABC-ATPase subunit interface; other site 649639001469 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649639001470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639001471 dimer interface [polypeptide binding]; other site 649639001472 conserved gate region; other site 649639001473 putative PBP binding loops; other site 649639001474 ABC-ATPase subunit interface; other site 649639001475 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 649639001476 conserved cys residue [active] 649639001477 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649639001478 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649639001479 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 649639001480 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 649639001481 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 649639001482 Protein of unknown function, DUF624; Region: DUF624; cl02369 649639001483 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649639001484 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649639001485 DNA binding site [nucleotide binding] 649639001486 domain linker motif; other site 649639001487 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 649639001488 putative dimerization interface [polypeptide binding]; other site 649639001489 putative ligand binding site [chemical binding]; other site 649639001490 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 649639001491 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 649639001492 Ca binding site [ion binding]; other site 649639001493 active site 649639001494 catalytic site [active] 649639001495 Predicted membrane protein [Function unknown]; Region: COG2323 649639001496 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649639001497 MarR family; Region: MarR; pfam01047 649639001498 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 649639001499 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 649639001500 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 649639001501 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649639001502 Zn binding site [ion binding]; other site 649639001503 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 649639001504 Zn binding site [ion binding]; other site 649639001505 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649639001506 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639001507 dimer interface [polypeptide binding]; other site 649639001508 phosphorylation site [posttranslational modification] 649639001509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639001510 ATP binding site [chemical binding]; other site 649639001511 Mg2+ binding site [ion binding]; other site 649639001512 G-X-G motif; other site 649639001513 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 649639001514 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 649639001515 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 649639001516 active site 649639001517 catalytic site [active] 649639001518 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 649639001519 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649639001520 ABC transporter; Region: ABC_tran_2; pfam12848 649639001521 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649639001522 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649639001523 oligoendopeptidase F; Region: pepF; TIGR00181 649639001524 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 649639001525 active site 649639001526 Zn binding site [ion binding]; other site 649639001527 Tic20-like protein; Region: Tic20; pfam09685 649639001528 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 649639001529 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 649639001530 FtsX-like permease family; Region: FtsX; pfam02687 649639001531 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 649639001532 FtsX-like permease family; Region: FtsX; pfam02687 649639001533 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649639001534 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 649639001535 Walker A/P-loop; other site 649639001536 ATP binding site [chemical binding]; other site 649639001537 Q-loop/lid; other site 649639001538 ABC transporter signature motif; other site 649639001539 Walker B; other site 649639001540 D-loop; other site 649639001541 H-loop/switch region; other site 649639001542 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649639001543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639001544 dimer interface [polypeptide binding]; other site 649639001545 phosphorylation site [posttranslational modification] 649639001546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639001547 ATP binding site [chemical binding]; other site 649639001548 Mg2+ binding site [ion binding]; other site 649639001549 G-X-G motif; other site 649639001550 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649639001551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639001552 active site 649639001553 phosphorylation site [posttranslational modification] 649639001554 intermolecular recognition site; other site 649639001555 dimerization interface [polypeptide binding]; other site 649639001556 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649639001557 DNA binding site [nucleotide binding] 649639001558 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 649639001559 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 649639001560 active site 649639001561 Zn binding site [ion binding]; other site 649639001562 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 649639001563 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 649639001564 DNA binding residues [nucleotide binding] 649639001565 dimer interface [polypeptide binding]; other site 649639001566 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 649639001567 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639001568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 649639001569 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 649639001570 polyphosphate kinase; Provisional; Region: PRK05443 649639001571 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 649639001572 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 649639001573 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 649639001574 putative domain interface [polypeptide binding]; other site 649639001575 putative active site [active] 649639001576 catalytic site [active] 649639001577 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 649639001578 putative domain interface [polypeptide binding]; other site 649639001579 putative active site [active] 649639001580 catalytic site [active] 649639001581 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 649639001582 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 649639001583 active site 649639001584 metal binding site [ion binding]; metal-binding site 649639001585 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 649639001586 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 649639001587 active site 649639001588 metal binding site [ion binding]; metal-binding site 649639001589 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 649639001590 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 649639001591 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649639001592 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649639001593 hypothetical protein; Provisional; Region: PRK07475 649639001594 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 649639001595 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 649639001596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639001597 catalytic residue [active] 649639001598 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 649639001599 putative active site pocket [active] 649639001600 dimerization interface [polypeptide binding]; other site 649639001601 putative catalytic residue [active] 649639001602 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 649639001603 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 649639001604 catalytic residues [active] 649639001605 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649639001606 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 649639001607 Walker A/P-loop; other site 649639001608 ATP binding site [chemical binding]; other site 649639001609 Q-loop/lid; other site 649639001610 ABC transporter signature motif; other site 649639001611 Walker B; other site 649639001612 D-loop; other site 649639001613 H-loop/switch region; other site 649639001614 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 649639001615 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 649639001616 HlyD family secretion protein; Region: HlyD_3; pfam13437 649639001617 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 649639001618 FtsX-like permease family; Region: FtsX; pfam02687 649639001619 FtsX-like permease family; Region: FtsX; pfam02687 649639001620 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 649639001621 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649639001622 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 649639001623 Walker A/P-loop; other site 649639001624 ATP binding site [chemical binding]; other site 649639001625 Q-loop/lid; other site 649639001626 ABC transporter signature motif; other site 649639001627 Walker B; other site 649639001628 D-loop; other site 649639001629 H-loop/switch region; other site 649639001630 Serpin (serine protease inhibitor); Region: Serpin; pfam00079 649639001631 serpin-like protein; Provisional; Region: PHA02660 649639001632 reactive center loop; other site 649639001633 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 649639001634 active site 649639001635 catalytic residues [active] 649639001636 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 649639001637 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 649639001638 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 649639001639 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 649639001640 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 649639001641 active site 649639001642 active site 649639001643 catalytic residues [active] 649639001644 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649639001645 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649639001646 DNA binding site [nucleotide binding] 649639001647 domain linker motif; other site 649639001648 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649639001649 ligand binding site [chemical binding]; other site 649639001650 dimerization interface [polypeptide binding]; other site 649639001651 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 649639001652 Peptidase family M48; Region: Peptidase_M48; cl12018 649639001653 multifunctional aminopeptidase A; Provisional; Region: PRK00913 649639001654 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 649639001655 interface (dimer of trimers) [polypeptide binding]; other site 649639001656 Substrate-binding/catalytic site; other site 649639001657 Zn-binding sites [ion binding]; other site 649639001658 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 649639001659 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649639001660 Histidine kinase; Region: HisKA_3; pfam07730 649639001661 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649639001662 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649639001663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639001664 active site 649639001665 phosphorylation site [posttranslational modification] 649639001666 intermolecular recognition site; other site 649639001667 dimerization interface [polypeptide binding]; other site 649639001668 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649639001669 DNA binding residues [nucleotide binding] 649639001670 dimerization interface [polypeptide binding]; other site 649639001671 Anti-repressor SinI; Region: SinI; pfam08671 649639001672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639001673 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649639001674 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649639001675 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649639001676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639001677 Walker A/P-loop; other site 649639001678 ATP binding site [chemical binding]; other site 649639001679 Q-loop/lid; other site 649639001680 ABC transporter signature motif; other site 649639001681 Walker B; other site 649639001682 D-loop; other site 649639001683 H-loop/switch region; other site 649639001684 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 649639001685 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 649639001686 Predicted integral membrane protein [Function unknown]; Region: COG5578 649639001687 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 649639001688 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 649639001689 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 649639001690 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 649639001691 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 649639001692 Ca binding site [ion binding]; other site 649639001693 carbohydrate binding site [chemical binding]; other site 649639001694 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 649639001695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639001696 active site 649639001697 phosphorylation site [posttranslational modification] 649639001698 intermolecular recognition site; other site 649639001699 dimerization interface [polypeptide binding]; other site 649639001700 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649639001701 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 649639001702 Histidine kinase; Region: His_kinase; pfam06580 649639001703 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649639001704 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649639001705 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 649639001706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639001707 dimer interface [polypeptide binding]; other site 649639001708 conserved gate region; other site 649639001709 ABC-ATPase subunit interface; other site 649639001710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 649639001711 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649639001712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639001713 dimer interface [polypeptide binding]; other site 649639001714 conserved gate region; other site 649639001715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 649639001716 ABC-ATPase subunit interface; other site 649639001717 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 649639001718 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 649639001719 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 649639001720 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 649639001721 D-mannonate oxidoreductase; Provisional; Region: PRK08277 649639001722 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 649639001723 putative NAD(P) binding site [chemical binding]; other site 649639001724 active site 649639001725 Glucuronate isomerase; Region: UxaC; pfam02614 649639001726 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 649639001727 xylose isomerase; Provisional; Region: PRK05474 649639001728 xylose isomerase; Region: xylose_isom_A; TIGR02630 649639001729 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 649639001730 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 649639001731 TPP-binding site [chemical binding]; other site 649639001732 dimer interface [polypeptide binding]; other site 649639001733 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 649639001734 PYR/PP interface [polypeptide binding]; other site 649639001735 dimer interface [polypeptide binding]; other site 649639001736 TPP binding site [chemical binding]; other site 649639001737 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 649639001738 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 649639001739 active site 649639001740 catalytic residues [active] 649639001741 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 649639001742 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 649639001743 inhibitor binding site; inhibition site 649639001744 active site 649639001745 MarR family; Region: MarR_2; pfam12802 649639001746 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 649639001747 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 649639001748 nucleotide binding site [chemical binding]; other site 649639001749 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 649639001750 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649639001751 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649639001752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639001753 dimer interface [polypeptide binding]; other site 649639001754 putative PBP binding loops; other site 649639001755 ABC-ATPase subunit interface; other site 649639001756 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649639001757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639001758 dimer interface [polypeptide binding]; other site 649639001759 conserved gate region; other site 649639001760 putative PBP binding loops; other site 649639001761 ABC-ATPase subunit interface; other site 649639001762 Predicted integral membrane protein [Function unknown]; Region: COG5578 649639001763 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 649639001764 N- and C-terminal domain interface [polypeptide binding]; other site 649639001765 D-xylulose kinase; Region: XylB; TIGR01312 649639001766 active site 649639001767 MgATP binding site [chemical binding]; other site 649639001768 catalytic site [active] 649639001769 metal binding site [ion binding]; metal-binding site 649639001770 xylulose binding site [chemical binding]; other site 649639001771 homodimer interface [polypeptide binding]; other site 649639001772 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 649639001773 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639001774 dimer interface [polypeptide binding]; other site 649639001775 phosphorylation site [posttranslational modification] 649639001776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639001777 ATP binding site [chemical binding]; other site 649639001778 Mg2+ binding site [ion binding]; other site 649639001779 G-X-G motif; other site 649639001780 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639001781 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 649639001782 active site 649639001783 motif I; other site 649639001784 motif II; other site 649639001785 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 649639001786 hypothetical protein; Provisional; Region: PRK06770 649639001787 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 649639001788 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 649639001789 oligomer interface [polypeptide binding]; other site 649639001790 active site 649639001791 metal binding site [ion binding]; metal-binding site 649639001792 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 649639001793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639001794 putative substrate translocation pore; other site 649639001795 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649639001796 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649639001797 active site 649639001798 catalytic tetrad [active] 649639001799 Ion transport protein; Region: Ion_trans; pfam00520 649639001800 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 649639001801 transmembrane helices; other site 649639001802 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 649639001803 TrkA-C domain; Region: TrkA_C; pfam02080 649639001804 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 649639001805 TrkA-C domain; Region: TrkA_C; pfam02080 649639001806 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 649639001807 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 649639001808 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 649639001809 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 649639001810 dimer interface [polypeptide binding]; other site 649639001811 active site 649639001812 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 649639001813 catalytic residues [active] 649639001814 substrate binding site [chemical binding]; other site 649639001815 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 649639001816 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 649639001817 NAD(P) binding pocket [chemical binding]; other site 649639001818 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649639001819 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649639001820 active site 649639001821 catalytic tetrad [active] 649639001822 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 649639001823 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 649639001824 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 649639001825 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 649639001826 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 649639001827 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 649639001828 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 649639001829 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 649639001830 DoxX; Region: DoxX; cl17842 649639001831 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 649639001832 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 649639001833 Zn2+ binding site [ion binding]; other site 649639001834 Mg2+ binding site [ion binding]; other site 649639001835 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 649639001836 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 649639001837 THF binding site; other site 649639001838 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 649639001839 substrate binding site [chemical binding]; other site 649639001840 THF binding site; other site 649639001841 zinc-binding site [ion binding]; other site 649639001842 DoxX; Region: DoxX; cl17842 649639001843 phosphodiesterase YaeI; Provisional; Region: PRK11340 649639001844 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 649639001845 putative active site [active] 649639001846 putative metal binding site [ion binding]; other site 649639001847 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 649639001848 ABC1 family; Region: ABC1; cl17513 649639001849 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 649639001850 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 649639001851 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649639001852 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649639001853 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 649639001854 putative active site [active] 649639001855 heme pocket [chemical binding]; other site 649639001856 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649639001857 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 649639001858 putative active site [active] 649639001859 heme pocket [chemical binding]; other site 649639001860 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639001861 dimer interface [polypeptide binding]; other site 649639001862 phosphorylation site [posttranslational modification] 649639001863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639001864 ATP binding site [chemical binding]; other site 649639001865 Mg2+ binding site [ion binding]; other site 649639001866 G-X-G motif; other site 649639001867 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 649639001868 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 649639001869 Nucleoside recognition; Region: Gate; pfam07670 649639001870 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 649639001871 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 649639001872 nudix motif; other site 649639001873 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 649639001874 nudix motif; other site 649639001875 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 649639001876 catalytic core [active] 649639001877 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 649639001878 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 649639001879 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 649639001880 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 649639001881 active site 649639001882 metal binding site [ion binding]; metal-binding site 649639001883 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 649639001884 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 649639001885 NAD binding site [chemical binding]; other site 649639001886 ligand binding site [chemical binding]; other site 649639001887 catalytic site [active] 649639001888 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649639001889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639001890 active site 649639001891 phosphorylation site [posttranslational modification] 649639001892 intermolecular recognition site; other site 649639001893 dimerization interface [polypeptide binding]; other site 649639001894 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649639001895 DNA binding site [nucleotide binding] 649639001896 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649639001897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639001898 ATP binding site [chemical binding]; other site 649639001899 Mg2+ binding site [ion binding]; other site 649639001900 G-X-G motif; other site 649639001901 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649639001902 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 649639001903 Walker A/P-loop; other site 649639001904 ATP binding site [chemical binding]; other site 649639001905 Q-loop/lid; other site 649639001906 ABC transporter signature motif; other site 649639001907 Walker B; other site 649639001908 D-loop; other site 649639001909 H-loop/switch region; other site 649639001910 Uncharacterized conserved protein [Function unknown]; Region: COG3937 649639001911 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 649639001912 ABC1 family; Region: ABC1; pfam03109 649639001913 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 649639001914 active site 649639001915 ATP binding site [chemical binding]; other site 649639001916 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649639001917 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649639001918 dimer interface [polypeptide binding]; other site 649639001919 putative CheW interface [polypeptide binding]; other site 649639001920 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 649639001921 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 649639001922 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 649639001923 rad50; Region: rad50; TIGR00606 649639001924 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 649639001925 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 649639001926 ligand binding site [chemical binding]; other site 649639001927 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 649639001928 Chitin binding domain; Region: Chitin_bind_3; pfam03067 649639001929 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 649639001930 aromatic chitin/cellulose binding site residues [chemical binding]; other site 649639001931 nuclear-egress-membrane-like protein; Provisional; Region: PHA03325 649639001932 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 649639001933 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 649639001934 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 649639001935 aromatic chitin/cellulose binding site residues [chemical binding]; other site 649639001936 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 649639001937 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639001938 Coenzyme A binding pocket [chemical binding]; other site 649639001939 EamA-like transporter family; Region: EamA; pfam00892 649639001940 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 649639001941 EamA-like transporter family; Region: EamA; pfam00892 649639001942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639001943 Coenzyme A binding pocket [chemical binding]; other site 649639001944 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 649639001945 active site 649639001946 putative substrate binding region [chemical binding]; other site 649639001947 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 649639001948 Eukaryotic phosphomannomutase; Region: PMM; cl17107 649639001949 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639001950 motif II; other site 649639001951 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649639001952 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 649639001953 Walker A/P-loop; other site 649639001954 ATP binding site [chemical binding]; other site 649639001955 Q-loop/lid; other site 649639001956 ABC transporter signature motif; other site 649639001957 Walker B; other site 649639001958 D-loop; other site 649639001959 H-loop/switch region; other site 649639001960 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649639001961 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639001962 Coenzyme A binding pocket [chemical binding]; other site 649639001963 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649639001964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639001965 S-adenosylmethionine binding site [chemical binding]; other site 649639001966 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 649639001967 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 649639001968 dimer interface [polypeptide binding]; other site 649639001969 active site 649639001970 CoA binding pocket [chemical binding]; other site 649639001971 AAA domain; Region: AAA_17; pfam13207 649639001972 AAA domain; Region: AAA_18; pfam13238 649639001973 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649639001974 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649639001975 active site 649639001976 catalytic tetrad [active] 649639001977 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649639001978 Beta-lactamase; Region: Beta-lactamase; pfam00144 649639001979 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 649639001980 DNA-binding site [nucleotide binding]; DNA binding site 649639001981 RNA-binding motif; other site 649639001982 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649639001983 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649639001984 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 649639001985 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 649639001986 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 649639001987 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 649639001988 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 649639001989 active site 649639001990 catalytic site [active] 649639001991 metal binding site [ion binding]; metal-binding site 649639001992 dimer interface [polypeptide binding]; other site 649639001993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639001994 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649639001995 putative substrate translocation pore; other site 649639001996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639001997 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 649639001998 active site 649639001999 catalytic site [active] 649639002000 heat shock protein HtpX; Provisional; Region: PRK05457 649639002001 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639002002 Coenzyme A binding pocket [chemical binding]; other site 649639002003 Pathogenicity locus; Region: Cdd1; pfam11731 649639002004 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649639002005 dimerization interface [polypeptide binding]; other site 649639002006 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649639002007 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649639002008 dimer interface [polypeptide binding]; other site 649639002009 putative CheW interface [polypeptide binding]; other site 649639002010 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649639002011 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649639002012 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 649639002013 classical (c) SDRs; Region: SDR_c; cd05233 649639002014 NAD(P) binding site [chemical binding]; other site 649639002015 active site 649639002016 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 649639002017 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 649639002018 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649639002019 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649639002020 dimer interface [polypeptide binding]; other site 649639002021 putative CheW interface [polypeptide binding]; other site 649639002022 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649639002023 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649639002024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639002025 dimer interface [polypeptide binding]; other site 649639002026 conserved gate region; other site 649639002027 putative PBP binding loops; other site 649639002028 ABC-ATPase subunit interface; other site 649639002029 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649639002030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639002031 dimer interface [polypeptide binding]; other site 649639002032 conserved gate region; other site 649639002033 putative PBP binding loops; other site 649639002034 ABC-ATPase subunit interface; other site 649639002035 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649639002036 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649639002037 DNA binding site [nucleotide binding] 649639002038 domain linker motif; other site 649639002039 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649639002040 ligand binding site [chemical binding]; other site 649639002041 dimerization interface [polypeptide binding]; other site 649639002042 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649639002043 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649639002044 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 649639002045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639002046 dimer interface [polypeptide binding]; other site 649639002047 putative PBP binding loops; other site 649639002048 ABC-ATPase subunit interface; other site 649639002049 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649639002050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639002051 dimer interface [polypeptide binding]; other site 649639002052 conserved gate region; other site 649639002053 putative PBP binding loops; other site 649639002054 ABC-ATPase subunit interface; other site 649639002055 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649639002056 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649639002057 DNA binding site [nucleotide binding] 649639002058 domain linker motif; other site 649639002059 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649639002060 ligand binding site [chemical binding]; other site 649639002061 dimerization interface [polypeptide binding]; other site 649639002062 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649639002063 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649639002064 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 649639002065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639002066 ABC-ATPase subunit interface; other site 649639002067 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649639002068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639002069 dimer interface [polypeptide binding]; other site 649639002070 conserved gate region; other site 649639002071 putative PBP binding loops; other site 649639002072 ABC-ATPase subunit interface; other site 649639002073 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649639002074 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649639002075 DNA binding site [nucleotide binding] 649639002076 domain linker motif; other site 649639002077 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649639002078 dimerization interface [polypeptide binding]; other site 649639002079 ligand binding site [chemical binding]; other site 649639002080 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649639002081 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649639002082 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 649639002083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639002084 putative PBP binding loops; other site 649639002085 ABC-ATPase subunit interface; other site 649639002086 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649639002087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639002088 dimer interface [polypeptide binding]; other site 649639002089 conserved gate region; other site 649639002090 putative PBP binding loops; other site 649639002091 ABC-ATPase subunit interface; other site 649639002092 Protein of unknown function, DUF624; Region: DUF624; cl02369 649639002093 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 649639002094 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 649639002095 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 649639002096 active site 649639002097 catalytic residues [active] 649639002098 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 649639002099 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 649639002100 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 649639002101 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 649639002102 beta-D-glucuronidase; Provisional; Region: PRK10150 649639002103 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 649639002104 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 649639002105 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 649639002106 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649639002107 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649639002108 DNA binding site [nucleotide binding] 649639002109 domain linker motif; other site 649639002110 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649639002111 dimerization interface [polypeptide binding]; other site 649639002112 ligand binding site [chemical binding]; other site 649639002113 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649639002114 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649639002115 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 649639002116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639002117 putative PBP binding loops; other site 649639002118 ABC-ATPase subunit interface; other site 649639002119 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649639002120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639002121 dimer interface [polypeptide binding]; other site 649639002122 conserved gate region; other site 649639002123 putative PBP binding loops; other site 649639002124 ABC-ATPase subunit interface; other site 649639002125 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 649639002126 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 649639002127 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 649639002128 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 649639002129 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 649639002130 active site 649639002131 catalytic residues [active] 649639002132 Prefoldin subunit; Region: Prefoldin_2; pfam01920 649639002133 ABC-2 type transporter; Region: ABC2_membrane; cl17235 649639002134 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 649639002135 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639002136 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 649639002137 Walker A/P-loop; other site 649639002138 ATP binding site [chemical binding]; other site 649639002139 Q-loop/lid; other site 649639002140 ABC transporter signature motif; other site 649639002141 Walker B; other site 649639002142 D-loop; other site 649639002143 H-loop/switch region; other site 649639002144 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 649639002145 hypothetical protein; Provisional; Region: PRK04164 649639002146 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 649639002147 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 649639002148 aromatic arch; other site 649639002149 DCoH dimer interaction site [polypeptide binding]; other site 649639002150 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 649639002151 DCoH tetramer interaction site [polypeptide binding]; other site 649639002152 substrate binding site [chemical binding]; other site 649639002153 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 649639002154 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 649639002155 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 649639002156 putative dimer interface [polypeptide binding]; other site 649639002157 N-terminal domain interface [polypeptide binding]; other site 649639002158 putative substrate binding pocket (H-site) [chemical binding]; other site 649639002159 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 649639002160 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639002161 Coenzyme A binding pocket [chemical binding]; other site 649639002162 CAAX protease self-immunity; Region: Abi; pfam02517 649639002163 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649639002164 Histidine kinase; Region: HisKA_3; pfam07730 649639002165 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649639002166 ATP binding site [chemical binding]; other site 649639002167 Mg2+ binding site [ion binding]; other site 649639002168 G-X-G motif; other site 649639002169 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649639002170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639002171 active site 649639002172 phosphorylation site [posttranslational modification] 649639002173 intermolecular recognition site; other site 649639002174 dimerization interface [polypeptide binding]; other site 649639002175 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649639002176 DNA binding residues [nucleotide binding] 649639002177 dimerization interface [polypeptide binding]; other site 649639002178 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649639002179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639002180 Walker A/P-loop; other site 649639002181 ATP binding site [chemical binding]; other site 649639002182 Q-loop/lid; other site 649639002183 ABC transporter signature motif; other site 649639002184 Walker B; other site 649639002185 D-loop; other site 649639002186 H-loop/switch region; other site 649639002187 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 649639002188 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 649639002189 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 649639002190 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 649639002191 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 649639002192 putative NAD(P) binding site [chemical binding]; other site 649639002193 active site 649639002194 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 649639002195 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649639002196 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 649639002197 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 649639002198 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 649639002199 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 649639002200 Transposase, Mutator family; Region: Transposase_mut; pfam00872 649639002201 MULE transposase domain; Region: MULE; pfam10551 649639002202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 649639002203 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 649639002204 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 649639002205 azoreductase; Provisional; Region: PRK13556 649639002206 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649639002207 MarR family; Region: MarR; pfam01047 649639002208 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 649639002209 nudix motif; other site 649639002210 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 649639002211 catalytic core [active] 649639002212 heat shock protein 90; Provisional; Region: PRK05218 649639002213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639002214 ATP binding site [chemical binding]; other site 649639002215 Mg2+ binding site [ion binding]; other site 649639002216 G-X-G motif; other site 649639002217 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649639002218 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649639002219 topology modulation protein; Reviewed; Region: PRK08118 649639002220 AAA domain; Region: AAA_17; pfam13207 649639002221 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649639002222 MarR family; Region: MarR; pfam01047 649639002223 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 649639002224 Protein export membrane protein; Region: SecD_SecF; cl14618 649639002225 Protein export membrane protein; Region: SecD_SecF; cl14618 649639002226 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 649639002227 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 649639002228 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 649639002229 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 649639002230 Beta-lactamase; Region: Beta-lactamase; pfam00144 649639002231 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649639002232 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649639002233 putative DNA binding site [nucleotide binding]; other site 649639002234 dimerization interface [polypeptide binding]; other site 649639002235 putative Zn2+ binding site [ion binding]; other site 649639002236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3860 649639002237 Abhydrolase family; Region: Abhydrolase_7; pfam12715 649639002238 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 649639002239 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 649639002240 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639002241 motif II; other site 649639002242 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 649639002243 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639002244 Coenzyme A binding pocket [chemical binding]; other site 649639002245 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 649639002246 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 649639002247 active site 649639002248 putative substrate binding pocket [chemical binding]; other site 649639002249 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649639002250 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649639002251 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639002252 Walker A/P-loop; other site 649639002253 ATP binding site [chemical binding]; other site 649639002254 Q-loop/lid; other site 649639002255 ABC transporter signature motif; other site 649639002256 Walker B; other site 649639002257 D-loop; other site 649639002258 H-loop/switch region; other site 649639002259 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649639002260 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649639002261 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 649639002262 Walker A/P-loop; other site 649639002263 ATP binding site [chemical binding]; other site 649639002264 Q-loop/lid; other site 649639002265 ABC transporter signature motif; other site 649639002266 Walker B; other site 649639002267 D-loop; other site 649639002268 H-loop/switch region; other site 649639002269 calcium/proton exchanger (cax); Region: cax; TIGR00378 649639002270 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 649639002271 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 649639002272 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 649639002273 Double zinc ribbon; Region: DZR; pfam12773 649639002274 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 649639002275 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 649639002276 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649639002277 non-specific DNA binding site [nucleotide binding]; other site 649639002278 salt bridge; other site 649639002279 sequence-specific DNA binding site [nucleotide binding]; other site 649639002280 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649639002281 binding surface 649639002282 TPR motif; other site 649639002283 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 649639002284 active site 649639002285 dimer interface [polypeptide binding]; other site 649639002286 Thioredoxin; Region: Thioredoxin_4; cl17273 649639002287 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 649639002288 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649639002289 ATP binding site [chemical binding]; other site 649639002290 putative Mg++ binding site [ion binding]; other site 649639002291 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649639002292 nucleotide binding region [chemical binding]; other site 649639002293 ATP-binding site [chemical binding]; other site 649639002294 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 649639002295 HRDC domain; Region: HRDC; pfam00570 649639002296 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 649639002297 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 649639002298 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 649639002299 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 649639002300 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639002301 dimer interface [polypeptide binding]; other site 649639002302 phosphorylation site [posttranslational modification] 649639002303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639002304 ATP binding site [chemical binding]; other site 649639002305 Mg2+ binding site [ion binding]; other site 649639002306 G-X-G motif; other site 649639002307 Response regulator receiver domain; Region: Response_reg; pfam00072 649639002308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639002309 active site 649639002310 phosphorylation site [posttranslational modification] 649639002311 intermolecular recognition site; other site 649639002312 dimerization interface [polypeptide binding]; other site 649639002313 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649639002314 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639002315 dimer interface [polypeptide binding]; other site 649639002316 phosphorylation site [posttranslational modification] 649639002317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639002318 ATP binding site [chemical binding]; other site 649639002319 Mg2+ binding site [ion binding]; other site 649639002320 G-X-G motif; other site 649639002321 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649639002322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639002323 active site 649639002324 phosphorylation site [posttranslational modification] 649639002325 intermolecular recognition site; other site 649639002326 dimerization interface [polypeptide binding]; other site 649639002327 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649639002328 DNA binding site [nucleotide binding] 649639002329 Anti-repressor SinI; Region: SinI; pfam08671 649639002330 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649639002331 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649639002332 dimer interface [polypeptide binding]; other site 649639002333 putative CheW interface [polypeptide binding]; other site 649639002334 Predicted esterase [General function prediction only]; Region: COG0400 649639002335 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 649639002336 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 649639002337 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639002338 Walker A/P-loop; other site 649639002339 ATP binding site [chemical binding]; other site 649639002340 Q-loop/lid; other site 649639002341 ABC transporter signature motif; other site 649639002342 Walker B; other site 649639002343 D-loop; other site 649639002344 H-loop/switch region; other site 649639002345 ABC transporter; Region: ABC_tran_2; pfam12848 649639002346 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649639002347 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 649639002348 DEAD-like helicases superfamily; Region: DEXDc; smart00487 649639002349 ATP binding site [chemical binding]; other site 649639002350 putative Mg++ binding site [ion binding]; other site 649639002351 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649639002352 nucleotide binding region [chemical binding]; other site 649639002353 ATP-binding site [chemical binding]; other site 649639002354 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 649639002355 Protein of unknown function DUF58; Region: DUF58; pfam01882 649639002356 MoxR-like ATPases [General function prediction only]; Region: COG0714 649639002357 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639002358 Walker A motif; other site 649639002359 ATP binding site [chemical binding]; other site 649639002360 Walker B motif; other site 649639002361 arginine finger; other site 649639002362 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 649639002363 TraB family; Region: TraB; pfam01963 649639002364 SWIM zinc finger; Region: SWIM; pfam04434 649639002365 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 649639002366 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 649639002367 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649639002368 ATP binding site [chemical binding]; other site 649639002369 putative Mg++ binding site [ion binding]; other site 649639002370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649639002371 nucleotide binding region [chemical binding]; other site 649639002372 ATP-binding site [chemical binding]; other site 649639002373 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 649639002374 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 649639002375 ATP binding site [chemical binding]; other site 649639002376 Mg++ binding site [ion binding]; other site 649639002377 motif III; other site 649639002378 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649639002379 nucleotide binding region [chemical binding]; other site 649639002380 ATP-binding site [chemical binding]; other site 649639002381 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 649639002382 thiamine phosphate binding site [chemical binding]; other site 649639002383 active site 649639002384 pyrophosphate binding site [ion binding]; other site 649639002385 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 649639002386 dimer interface [polypeptide binding]; other site 649639002387 substrate binding site [chemical binding]; other site 649639002388 ATP binding site [chemical binding]; other site 649639002389 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 649639002390 ThiS interaction site; other site 649639002391 putative active site [active] 649639002392 tetramer interface [polypeptide binding]; other site 649639002393 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 649639002394 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649639002395 FeS/SAM binding site; other site 649639002396 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 649639002397 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 649639002398 thiamine phosphate binding site [chemical binding]; other site 649639002399 active site 649639002400 pyrophosphate binding site [ion binding]; other site 649639002401 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 649639002402 thiS-thiF/thiG interaction site; other site 649639002403 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 649639002404 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 649639002405 ATP binding site [chemical binding]; other site 649639002406 substrate interface [chemical binding]; other site 649639002407 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 649639002408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639002409 Walker A/P-loop; other site 649639002410 ATP binding site [chemical binding]; other site 649639002411 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649639002412 ABC transporter signature motif; other site 649639002413 Walker B; other site 649639002414 D-loop; other site 649639002415 ABC transporter; Region: ABC_tran_2; pfam12848 649639002416 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649639002417 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 649639002418 Domain of unknown function DUF20; Region: UPF0118; pfam01594 649639002419 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 649639002420 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 649639002421 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 649639002422 dimer interface [polypeptide binding]; other site 649639002423 PYR/PP interface [polypeptide binding]; other site 649639002424 TPP binding site [chemical binding]; other site 649639002425 substrate binding site [chemical binding]; other site 649639002426 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 649639002427 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 649639002428 TPP-binding site [chemical binding]; other site 649639002429 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 649639002430 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 649639002431 Pyruvate formate lyase 1; Region: PFL1; cd01678 649639002432 coenzyme A binding site [chemical binding]; other site 649639002433 active site 649639002434 catalytic residues [active] 649639002435 glycine loop; other site 649639002436 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 649639002437 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649639002438 FeS/SAM binding site; other site 649639002439 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639002440 Coenzyme A binding pocket [chemical binding]; other site 649639002441 rod shape-determining protein MreB; Provisional; Region: PRK13930 649639002442 MreB and similar proteins; Region: MreB_like; cd10225 649639002443 nucleotide binding site [chemical binding]; other site 649639002444 Mg binding site [ion binding]; other site 649639002445 putative protofilament interaction site [polypeptide binding]; other site 649639002446 RodZ interaction site [polypeptide binding]; other site 649639002447 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 649639002448 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 649639002449 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 649639002450 active site 649639002451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 649639002452 MOSC domain; Region: MOSC; pfam03473 649639002453 3-alpha domain; Region: 3-alpha; pfam03475 649639002454 Domain of unknown function (DUF897); Region: DUF897; cl01312 649639002455 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 649639002456 metal binding site [ion binding]; metal-binding site 649639002457 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 649639002458 Amidinotransferase; Region: Amidinotransf; pfam02274 649639002459 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 649639002460 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 649639002461 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 649639002462 catalytic residue [active] 649639002463 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 649639002464 multidrug efflux protein; Reviewed; Region: PRK01766 649639002465 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 649639002466 cation binding site [ion binding]; other site 649639002467 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 649639002468 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 649639002469 NAD(P) binding site [chemical binding]; other site 649639002470 catalytic residues [active] 649639002471 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 649639002472 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639002473 Coenzyme A binding pocket [chemical binding]; other site 649639002474 Acylphosphatase; Region: Acylphosphatase; pfam00708 649639002475 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 649639002476 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 649639002477 putative acyl-acceptor binding pocket; other site 649639002478 SCP-2 sterol transfer family; Region: SCP2; pfam02036 649639002479 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 649639002480 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 649639002481 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 649639002482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639002483 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649639002484 putative substrate translocation pore; other site 649639002485 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 649639002486 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 649639002487 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 649639002488 Transposase; Region: DEDD_Tnp_IS110; pfam01548 649639002489 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 649639002490 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 649639002491 YfkD-like protein; Region: YfkD; pfam14167 649639002492 Radical SAM superfamily; Region: Radical_SAM; pfam04055 649639002493 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649639002494 FeS/SAM binding site; other site 649639002495 YfkB-like domain; Region: YfkB; pfam08756 649639002496 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 649639002497 dimer interface [polypeptide binding]; other site 649639002498 FMN binding site [chemical binding]; other site 649639002499 NADPH bind site [chemical binding]; other site 649639002500 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 649639002501 catalytic core [active] 649639002502 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 649639002503 Fumarase C-terminus; Region: Fumerase_C; pfam05683 649639002504 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 649639002505 apolar tunnel; other site 649639002506 heme binding site [chemical binding]; other site 649639002507 dimerization interface [polypeptide binding]; other site 649639002508 dihydroorotate dehydrogenase, subfamily 2; Region: pyrD_sub2; TIGR01036 649639002509 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 649639002510 phosphate binding site [ion binding]; other site 649639002511 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 649639002512 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 649639002513 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 649639002514 NodB motif; other site 649639002515 active site 649639002516 catalytic site [active] 649639002517 Cd binding site [ion binding]; other site 649639002518 GAF domain; Region: GAF_2; pfam13185 649639002519 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 649639002520 endonuclease III; Region: ENDO3c; smart00478 649639002521 minor groove reading motif; other site 649639002522 helix-hairpin-helix signature motif; other site 649639002523 substrate binding pocket [chemical binding]; other site 649639002524 active site 649639002525 TRAM domain; Region: TRAM; pfam01938 649639002526 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 649639002527 Organic solute transport protein 1; Region: Oscp1; pfam10188 649639002528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639002529 S-adenosylmethionine binding site [chemical binding]; other site 649639002530 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 649639002531 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649639002532 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649639002533 Helix-turn-helix domain; Region: HTH_18; pfam12833 649639002534 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 649639002535 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 649639002536 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649639002537 MarR family; Region: MarR; pfam01047 649639002538 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 649639002539 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 649639002540 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 649639002541 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 649639002542 Cupin domain; Region: Cupin_2; pfam07883 649639002543 Helix-turn-helix domain; Region: HTH_18; pfam12833 649639002544 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649639002545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639002546 H+ Antiporter protein; Region: 2A0121; TIGR00900 649639002547 putative substrate translocation pore; other site 649639002548 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649639002549 dimerization interface [polypeptide binding]; other site 649639002550 putative DNA binding site [nucleotide binding]; other site 649639002551 putative Zn2+ binding site [ion binding]; other site 649639002552 Cache domain; Region: Cache_1; pfam02743 649639002553 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649639002554 dimerization interface [polypeptide binding]; other site 649639002555 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649639002556 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649639002557 dimer interface [polypeptide binding]; other site 649639002558 putative CheW interface [polypeptide binding]; other site 649639002559 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 649639002560 heme-binding site [chemical binding]; other site 649639002561 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649639002562 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649639002563 dimer interface [polypeptide binding]; other site 649639002564 putative CheW interface [polypeptide binding]; other site 649639002565 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 649639002566 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 649639002567 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 649639002568 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 649639002569 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 649639002570 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 649639002571 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 649639002572 Predicted permeases [General function prediction only]; Region: COG0701 649639002573 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 649639002574 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 649639002575 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 649639002576 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 649639002577 trimerization site [polypeptide binding]; other site 649639002578 active site 649639002579 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 649639002580 dimer interface [polypeptide binding]; other site 649639002581 [2Fe-2S] cluster binding site [ion binding]; other site 649639002582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649639002583 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649639002584 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 649639002585 stage V sporulation protein AD; Provisional; Region: PRK12404 649639002586 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 649639002587 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 649639002588 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 649639002589 active site turn [active] 649639002590 phosphorylation site [posttranslational modification] 649639002591 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 649639002592 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 649639002593 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 649639002594 putative DNA binding site [nucleotide binding]; other site 649639002595 catalytic residue [active] 649639002596 putative H2TH interface [polypeptide binding]; other site 649639002597 putative catalytic residues [active] 649639002598 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 649639002599 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 649639002600 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 649639002601 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639002602 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649639002603 DNA binding residues [nucleotide binding] 649639002604 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 649639002605 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 649639002606 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649639002607 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 649639002608 putative active site [active] 649639002609 heme pocket [chemical binding]; other site 649639002610 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649639002611 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 649639002612 putative active site [active] 649639002613 heme pocket [chemical binding]; other site 649639002614 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 649639002615 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649639002616 putative active site [active] 649639002617 heme pocket [chemical binding]; other site 649639002618 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639002619 dimer interface [polypeptide binding]; other site 649639002620 phosphorylation site [posttranslational modification] 649639002621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639002622 ATP binding site [chemical binding]; other site 649639002623 Mg2+ binding site [ion binding]; other site 649639002624 G-X-G motif; other site 649639002625 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 649639002626 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 649639002627 catalytic residues [active] 649639002628 dimer interface [polypeptide binding]; other site 649639002629 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 649639002630 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 649639002631 hypothetical protein; Provisional; Region: PRK08236 649639002632 Isochorismatase family; Region: Isochorismatase; pfam00857 649639002633 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 649639002634 catalytic triad [active] 649639002635 conserved cis-peptide bond; other site 649639002636 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639002637 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 649639002638 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649639002639 DNA binding residues [nucleotide binding] 649639002640 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 649639002641 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 649639002642 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 649639002643 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 649639002644 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 649639002645 Helix-turn-helix domain; Region: HTH_17; cl17695 649639002646 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 649639002647 aspartate kinase; Reviewed; Region: PRK09034 649639002648 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 649639002649 nucleotide binding site [chemical binding]; other site 649639002650 substrate binding site [chemical binding]; other site 649639002651 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 649639002652 allosteric regulatory residue; other site 649639002653 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 649639002654 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649639002655 non-specific DNA binding site [nucleotide binding]; other site 649639002656 salt bridge; other site 649639002657 sequence-specific DNA binding site [nucleotide binding]; other site 649639002658 homoserine O-succinyltransferase; Provisional; Region: PRK05368 649639002659 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 649639002660 proposed active site lysine [active] 649639002661 conserved cys residue [active] 649639002662 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649639002663 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649639002664 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 649639002665 Walker A/P-loop; other site 649639002666 ATP binding site [chemical binding]; other site 649639002667 Q-loop/lid; other site 649639002668 ABC transporter signature motif; other site 649639002669 Walker B; other site 649639002670 D-loop; other site 649639002671 H-loop/switch region; other site 649639002672 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 649639002673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639002674 putative substrate translocation pore; other site 649639002675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639002676 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 649639002677 [2Fe-2S] cluster binding site [ion binding]; other site 649639002678 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 649639002679 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 649639002680 [4Fe-4S] binding site [ion binding]; other site 649639002681 molybdopterin cofactor binding site; other site 649639002682 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 649639002683 molybdopterin cofactor binding site; other site 649639002684 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547 649639002685 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 649639002686 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 649639002687 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 649639002688 active site 649639002689 SAM binding site [chemical binding]; other site 649639002690 homodimer interface [polypeptide binding]; other site 649639002691 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 649639002692 putative active site [active] 649639002693 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 649639002694 putative active site [active] 649639002695 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 649639002696 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 649639002697 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 649639002698 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 649639002699 NAD binding site [chemical binding]; other site 649639002700 ligand binding site [chemical binding]; other site 649639002701 catalytic site [active] 649639002702 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 649639002703 active site 649639002704 DNA binding site [nucleotide binding] 649639002705 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 649639002706 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 649639002707 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 649639002708 XdhC Rossmann domain; Region: XdhC_C; pfam13478 649639002709 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 649639002710 Ligand binding site; other site 649639002711 metal-binding site 649639002712 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 649639002713 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 649639002714 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 649639002715 Amidase; Region: Amidase; cl11426 649639002716 indole-3-acetamide amidohydrolase; Region: PLN02722 649639002717 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 649639002718 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 649639002719 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 649639002720 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 649639002721 active site 649639002722 homodimer interface [polypeptide binding]; other site 649639002723 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 649639002724 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639002725 dimer interface [polypeptide binding]; other site 649639002726 phosphorylation site [posttranslational modification] 649639002727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639002728 ATP binding site [chemical binding]; other site 649639002729 Mg2+ binding site [ion binding]; other site 649639002730 G-X-G motif; other site 649639002731 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 649639002732 Na2 binding site [ion binding]; other site 649639002733 putative substrate binding site 1 [chemical binding]; other site 649639002734 Na binding site 1 [ion binding]; other site 649639002735 putative substrate binding site 2 [chemical binding]; other site 649639002736 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 649639002737 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 649639002738 active site 649639002739 S-formylglutathione hydrolase; Region: PLN02442 649639002740 Predicted esterase [General function prediction only]; Region: COG0627 649639002741 Predicted transcriptional regulators [Transcription]; Region: COG1733 649639002742 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 649639002743 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639002744 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639002745 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639002746 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639002747 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 649639002748 NlpC/P60 family; Region: NLPC_P60; pfam00877 649639002749 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 649639002750 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 649639002751 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649639002752 Coenzyme A binding pocket [chemical binding]; other site 649639002753 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 649639002754 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 649639002755 DNA binding residues [nucleotide binding] 649639002756 dimer interface [polypeptide binding]; other site 649639002757 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 649639002758 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 649639002759 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 649639002760 substrate binding pocket [chemical binding]; other site 649639002761 chain length determination region; other site 649639002762 substrate-Mg2+ binding site; other site 649639002763 catalytic residues [active] 649639002764 aspartate-rich region 1; other site 649639002765 active site lid residues [active] 649639002766 aspartate-rich region 2; other site 649639002767 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 649639002768 N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846 649639002769 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 649639002770 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649639002771 Predicted membrane protein [Function unknown]; Region: COG2259 649639002772 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 649639002773 ApbE family; Region: ApbE; pfam02424 649639002774 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 649639002775 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 649639002776 Walker A/P-loop; other site 649639002777 ATP binding site [chemical binding]; other site 649639002778 Q-loop/lid; other site 649639002779 ABC transporter signature motif; other site 649639002780 Walker B; other site 649639002781 D-loop; other site 649639002782 H-loop/switch region; other site 649639002783 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 649639002784 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 649639002785 Walker A/P-loop; other site 649639002786 ATP binding site [chemical binding]; other site 649639002787 Q-loop/lid; other site 649639002788 ABC transporter signature motif; other site 649639002789 Walker B; other site 649639002790 D-loop; other site 649639002791 H-loop/switch region; other site 649639002792 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 649639002793 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 649639002794 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 649639002795 YtkA-like; Region: YtkA; pfam13115 649639002796 YtkA-like; Region: YtkA; pfam13115 649639002797 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 649639002798 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 649639002799 Ca binding site [ion binding]; other site 649639002800 active site 649639002801 catalytic site [active] 649639002802 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 649639002803 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649639002804 DNA-binding site [nucleotide binding]; DNA binding site 649639002805 UTRA domain; Region: UTRA; pfam07702 649639002806 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 649639002807 nudix motif; other site 649639002808 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 649639002809 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639002810 Coenzyme A binding pocket [chemical binding]; other site 649639002811 tyrosine kinase; Provisional; Region: PRK11519 649639002812 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 649639002813 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 649639002814 YCII-related domain; Region: YCII; cl00999 649639002815 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649639002816 Beta-lactamase; Region: Beta-lactamase; pfam00144 649639002817 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 649639002818 Isochorismatase family; Region: Isochorismatase; pfam00857 649639002819 catalytic triad [active] 649639002820 conserved cis-peptide bond; other site 649639002821 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 649639002822 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 649639002823 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639002824 active site 649639002825 motif I; other site 649639002826 motif II; other site 649639002827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649639002828 binding surface 649639002829 TPR motif; other site 649639002830 Tetratrico peptide repeat; Region: TPR_5; pfam12688 649639002831 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 649639002832 binding surface 649639002833 TPR motif; other site 649639002834 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 649639002835 classical (c) SDRs; Region: SDR_c; cd05233 649639002836 NAD(P) binding site [chemical binding]; other site 649639002837 active site 649639002838 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 649639002839 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639002840 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 649639002841 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 649639002842 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 649639002843 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 649639002844 Phosphotransferase enzyme family; Region: APH; pfam01636 649639002845 putative active site [active] 649639002846 putative substrate binding site [chemical binding]; other site 649639002847 ATP binding site [chemical binding]; other site 649639002848 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 649639002849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649639002850 NADH(P)-binding; Region: NAD_binding_10; pfam13460 649639002851 NAD(P) binding site [chemical binding]; other site 649639002852 active site 649639002853 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 649639002854 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639002855 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649639002856 DNA binding residues [nucleotide binding] 649639002857 topology modulation protein; Reviewed; Region: PRK08118 649639002858 AAA domain; Region: AAA_17; pfam13207 649639002859 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 649639002860 YfhD-like protein; Region: YfhD; pfam14151 649639002861 YfhE-like protein; Region: YfhE; pfam14152 649639002862 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 649639002863 TIGR01777 family protein; Region: yfcH 649639002864 putative NAD(P) binding site [chemical binding]; other site 649639002865 putative active site [active] 649639002866 RecX family; Region: RecX; cl00936 649639002867 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 649639002868 Small acid-soluble spore protein K family; Region: SspK; pfam08176 649639002869 WVELL protein; Region: WVELL; pfam14043 649639002870 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 649639002871 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 649639002872 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 649639002873 minor groove reading motif; other site 649639002874 helix-hairpin-helix signature motif; other site 649639002875 substrate binding pocket [chemical binding]; other site 649639002876 active site 649639002877 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 649639002878 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 649639002879 DNA binding and oxoG recognition site [nucleotide binding] 649639002880 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 649639002881 classical (c) SDRs; Region: SDR_c; cd05233 649639002882 NAD(P) binding site [chemical binding]; other site 649639002883 active site 649639002884 Cupin domain; Region: Cupin_2; cl17218 649639002885 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 649639002886 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 649639002887 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 649639002888 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 649639002889 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649639002890 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 649639002891 NAD(P) binding site [chemical binding]; other site 649639002892 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 649639002893 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 649639002894 putative NAD(P) binding site [chemical binding]; other site 649639002895 active site 649639002896 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 649639002897 hypothetical protein; Provisional; Region: PRK13662 649639002898 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649639002899 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649639002900 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 649639002901 Walker A/P-loop; other site 649639002902 ATP binding site [chemical binding]; other site 649639002903 Q-loop/lid; other site 649639002904 ABC transporter signature motif; other site 649639002905 Walker B; other site 649639002906 D-loop; other site 649639002907 H-loop/switch region; other site 649639002908 Predicted membrane protein [Function unknown]; Region: COG4129 649639002909 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 649639002910 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 649639002911 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 649639002912 active site 649639002913 dimer interface [polypeptide binding]; other site 649639002914 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 649639002915 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 649639002916 active site 649639002917 FMN binding site [chemical binding]; other site 649639002918 substrate binding site [chemical binding]; other site 649639002919 3Fe-4S cluster binding site [ion binding]; other site 649639002920 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 649639002921 domain_subunit interface; other site 649639002922 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 649639002923 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 649639002924 inhibitor-cofactor binding pocket; inhibition site 649639002925 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639002926 catalytic residue [active] 649639002927 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 649639002928 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639002929 Walker A/P-loop; other site 649639002930 ATP binding site [chemical binding]; other site 649639002931 Q-loop/lid; other site 649639002932 ABC transporter signature motif; other site 649639002933 Walker B; other site 649639002934 D-loop; other site 649639002935 H-loop/switch region; other site 649639002936 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 649639002937 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 649639002938 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 649639002939 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 649639002940 Ion channel; Region: Ion_trans_2; pfam07885 649639002941 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 649639002942 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 649639002943 catalytic triad [active] 649639002944 Predicted transcriptional regulators [Transcription]; Region: COG1725 649639002945 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649639002946 DNA-binding site [nucleotide binding]; DNA binding site 649639002947 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 649639002948 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 649639002949 Walker A/P-loop; other site 649639002950 ATP binding site [chemical binding]; other site 649639002951 Q-loop/lid; other site 649639002952 ABC transporter signature motif; other site 649639002953 Walker B; other site 649639002954 D-loop; other site 649639002955 H-loop/switch region; other site 649639002956 Protein of unknown function (DUF970); Region: DUF970; cl17525 649639002957 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 649639002958 metal binding site 2 [ion binding]; metal-binding site 649639002959 putative DNA binding helix; other site 649639002960 metal binding site 1 [ion binding]; metal-binding site 649639002961 dimer interface [polypeptide binding]; other site 649639002962 structural Zn2+ binding site [ion binding]; other site 649639002963 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 649639002964 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 649639002965 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 649639002966 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639002967 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649639002968 DNA binding residues [nucleotide binding] 649639002969 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 649639002970 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649639002971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 649639002972 Uncharacterized conserved protein [Function unknown]; Region: COG2968 649639002973 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 649639002974 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 649639002975 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 649639002976 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639002977 Walker A/P-loop; other site 649639002978 ATP binding site [chemical binding]; other site 649639002979 Q-loop/lid; other site 649639002980 ABC transporter signature motif; other site 649639002981 Walker B; other site 649639002982 D-loop; other site 649639002983 H-loop/switch region; other site 649639002984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639002985 dimer interface [polypeptide binding]; other site 649639002986 conserved gate region; other site 649639002987 putative PBP binding loops; other site 649639002988 ABC-ATPase subunit interface; other site 649639002989 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649639002990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639002991 dimer interface [polypeptide binding]; other site 649639002992 conserved gate region; other site 649639002993 putative PBP binding loops; other site 649639002994 ABC-ATPase subunit interface; other site 649639002995 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649639002996 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 649639002997 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 649639002998 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649639002999 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649639003000 metal binding site [ion binding]; metal-binding site 649639003001 active site 649639003002 I-site; other site 649639003003 Uncharacterized conserved protein [Function unknown]; Region: COG4938 649639003004 Methyltransferase domain; Region: Methyltransf_31; pfam13847 649639003005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639003006 S-adenosylmethionine binding site [chemical binding]; other site 649639003007 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 649639003008 nudix motif; other site 649639003009 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 649639003010 molybdopterin cofactor binding site; other site 649639003011 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649639003012 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649639003013 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639003014 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 649639003015 Coenzyme A binding pocket [chemical binding]; other site 649639003016 putative transposase OrfB; Reviewed; Region: PHA02517 649639003017 HTH-like domain; Region: HTH_21; pfam13276 649639003018 Integrase core domain; Region: rve; pfam00665 649639003019 Integrase core domain; Region: rve_2; pfam13333 649639003020 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 649639003021 Helix-turn-helix domain; Region: HTH_28; pfam13518 649639003022 Homeodomain-like domain; Region: HTH_23; cl17451 649639003023 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 649639003024 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 649639003025 Ion channel; Region: Ion_trans_2; pfam07885 649639003026 Predicted transcriptional regulators [Transcription]; Region: COG1695 649639003027 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 649639003028 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 649639003029 MarR family; Region: MarR_2; pfam12802 649639003030 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 649639003031 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 649639003032 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 649639003033 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 649639003034 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 649639003035 putative substrate binding site [chemical binding]; other site 649639003036 active site 649639003037 MarR family; Region: MarR_2; pfam12802 649639003038 D-allose kinase; Provisional; Region: PRK09698 649639003039 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 649639003040 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649639003041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639003042 dimer interface [polypeptide binding]; other site 649639003043 conserved gate region; other site 649639003044 putative PBP binding loops; other site 649639003045 ABC-ATPase subunit interface; other site 649639003046 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 649639003047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639003048 dimer interface [polypeptide binding]; other site 649639003049 putative PBP binding loops; other site 649639003050 ABC-ATPase subunit interface; other site 649639003051 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649639003052 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649639003053 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 649639003054 putative substrate binding site [chemical binding]; other site 649639003055 active site 649639003056 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 649639003057 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 649639003058 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 649639003059 active site 649639003060 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 649639003061 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 649639003062 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 649639003063 Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991 649639003064 active site 649639003065 galactokinase; Provisional; Region: PRK05322 649639003066 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 649639003067 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 649639003068 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 649639003069 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 649639003070 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 649639003071 NAD binding site [chemical binding]; other site 649639003072 homodimer interface [polypeptide binding]; other site 649639003073 active site 649639003074 substrate binding site [chemical binding]; other site 649639003075 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 649639003076 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 649639003077 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 649639003078 MarR family; Region: MarR_2; pfam12802 649639003079 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 649639003080 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 649639003081 nucleotide binding site [chemical binding]; other site 649639003082 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 649639003083 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 649639003084 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649639003085 ligand binding site [chemical binding]; other site 649639003086 dimerization interface [polypeptide binding]; other site 649639003087 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649639003088 PAS fold; Region: PAS_3; pfam08447 649639003089 putative active site [active] 649639003090 heme pocket [chemical binding]; other site 649639003091 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649639003092 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649639003093 metal binding site [ion binding]; metal-binding site 649639003094 active site 649639003095 I-site; other site 649639003096 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649639003097 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649639003098 ligand binding site [chemical binding]; other site 649639003099 dimerization interface [polypeptide binding]; other site 649639003100 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649639003101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649639003102 PAS fold; Region: PAS_3; pfam08447 649639003103 putative active site [active] 649639003104 heme pocket [chemical binding]; other site 649639003105 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649639003106 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649639003107 metal binding site [ion binding]; metal-binding site 649639003108 active site 649639003109 I-site; other site 649639003110 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649639003111 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 649639003112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639003113 putative substrate translocation pore; other site 649639003114 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 649639003115 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649639003116 DNA binding residues [nucleotide binding] 649639003117 dimer interface [polypeptide binding]; other site 649639003118 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 649639003119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 649639003120 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 649639003121 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 649639003122 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 649639003123 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 649639003124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639003125 putative substrate translocation pore; other site 649639003126 H+ Antiporter protein; Region: 2A0121; TIGR00900 649639003127 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 649639003128 Predicted transcriptional regulators [Transcription]; Region: COG1695 649639003129 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 649639003130 DNA-binding ferritin-like protein (Dps family) [General function prediction only]; Region: COG4817 649639003131 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 649639003132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639003133 Walker A/P-loop; other site 649639003134 ATP binding site [chemical binding]; other site 649639003135 Q-loop/lid; other site 649639003136 ABC transporter signature motif; other site 649639003137 Walker B; other site 649639003138 D-loop; other site 649639003139 H-loop/switch region; other site 649639003140 ABC-2 type transporter; Region: ABC2_membrane; cl17235 649639003141 Predicted membrane protein [Function unknown]; Region: COG2311 649639003142 Protein of unknown function (DUF418); Region: DUF418; cl12135 649639003143 Protein of unknown function (DUF418); Region: DUF418; pfam04235 649639003144 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 649639003145 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 649639003146 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 649639003147 DEAD_2; Region: DEAD_2; pfam06733 649639003148 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 649639003149 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 649639003150 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639003151 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649639003152 DNA binding residues [nucleotide binding] 649639003153 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 649639003154 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 649639003155 Spore germination protein; Region: Spore_permease; cl17796 649639003156 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 649639003157 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649639003158 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649639003159 metal binding site [ion binding]; metal-binding site 649639003160 active site 649639003161 I-site; other site 649639003162 Staygreen protein; Region: Staygreen; pfam12638 649639003163 D-cysteine desulfhydrase; Validated; Region: PRK03910 649639003164 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 649639003165 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649639003166 catalytic residue [active] 649639003167 Predicted transcriptional regulators [Transcription]; Region: COG1695 649639003168 Transcriptional regulator PadR-like family; Region: PadR; cl17335 649639003169 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 649639003170 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 649639003171 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 649639003172 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 649639003173 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 649639003174 delta l-pyrroline-5-carboxylate synthetase; Region: P5CS; TIGR01092 649639003175 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 649639003176 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 649639003177 HIGH motif; other site 649639003178 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 649639003179 active site 649639003180 KMSKS motif; other site 649639003181 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 649639003182 tRNA binding surface [nucleotide binding]; other site 649639003183 anticodon binding site; other site 649639003184 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 649639003185 Na binding site [ion binding]; other site 649639003186 putative substrate binding site [chemical binding]; other site 649639003187 cytosine deaminase; Provisional; Region: PRK09230 649639003188 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 649639003189 active site 649639003190 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 649639003191 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639003192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639003193 Walker A/P-loop; other site 649639003194 Walker A/P-loop; other site 649639003195 ATP binding site [chemical binding]; other site 649639003196 ATP binding site [chemical binding]; other site 649639003197 Q-loop/lid; other site 649639003198 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649639003199 ABC transporter signature motif; other site 649639003200 Walker B; other site 649639003201 D-loop; other site 649639003202 ABC transporter; Region: ABC_tran_2; pfam12848 649639003203 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649639003204 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649639003205 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649639003206 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 649639003207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 649639003208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639003209 ABC-ATPase subunit interface; other site 649639003210 putative PBP binding loops; other site 649639003211 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649639003212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639003213 dimer interface [polypeptide binding]; other site 649639003214 conserved gate region; other site 649639003215 putative PBP binding loops; other site 649639003216 ABC-ATPase subunit interface; other site 649639003217 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 649639003218 Melibiase; Region: Melibiase; pfam02065 649639003219 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 649639003220 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649639003221 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 649639003222 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649639003223 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649639003224 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649639003225 DNA binding site [nucleotide binding] 649639003226 domain linker motif; other site 649639003227 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 649639003228 putative dimerization interface [polypeptide binding]; other site 649639003229 putative ligand binding site [chemical binding]; other site 649639003230 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 649639003231 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 649639003232 putative metal binding site [ion binding]; other site 649639003233 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 649639003234 metal binding site [ion binding]; metal-binding site 649639003235 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 649639003236 Ca binding site [ion binding]; other site 649639003237 Melibiase; Region: Melibiase; pfam02065 649639003238 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 649639003239 FOG: CBS domain [General function prediction only]; Region: COG0517 649639003240 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649639003241 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 649639003242 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649639003243 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 649639003244 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 649639003245 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 649639003246 Uncharacterized conserved protein [Function unknown]; Region: COG1284 649639003247 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 649639003248 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 649639003249 DEAD-like helicases superfamily; Region: DEXDc; smart00487 649639003250 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649639003251 ATP binding site [chemical binding]; other site 649639003252 putative Mg++ binding site [ion binding]; other site 649639003253 helicase superfamily c-terminal domain; Region: HELICc; smart00490 649639003254 SET domain; Region: SET; pfam00856 649639003255 Predicted integral membrane protein [Function unknown]; Region: COG5578 649639003256 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649639003257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639003258 dimer interface [polypeptide binding]; other site 649639003259 conserved gate region; other site 649639003260 putative PBP binding loops; other site 649639003261 ABC-ATPase subunit interface; other site 649639003262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639003263 dimer interface [polypeptide binding]; other site 649639003264 conserved gate region; other site 649639003265 putative PBP binding loops; other site 649639003266 ABC-ATPase subunit interface; other site 649639003267 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649639003268 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649639003269 Zn-ribbon containing protein (DUF2072); Region: DUF2072; pfam09845 649639003270 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649639003271 binding surface 649639003272 TPR motif; other site 649639003273 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 649639003274 DNA binding site [nucleotide binding] 649639003275 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 649639003276 HNH endonuclease; Region: HNH_2; pfam13391 649639003277 active site 649639003278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 649639003279 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 649639003280 Protein of unknown function (DUF524); Region: DUF524; pfam04411 649639003281 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 649639003282 active site 649639003283 DNA binding site [nucleotide binding] 649639003284 Int/Topo IB signature motif; other site 649639003285 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 649639003286 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 649639003287 cofactor binding site; other site 649639003288 DNA binding site [nucleotide binding] 649639003289 substrate interaction site [chemical binding]; other site 649639003290 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 649639003291 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 649639003292 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 649639003293 cofactor binding site; other site 649639003294 DNA binding site [nucleotide binding] 649639003295 substrate interaction site [chemical binding]; other site 649639003296 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 649639003297 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 649639003298 cofactor binding site; other site 649639003299 DNA binding site [nucleotide binding] 649639003300 substrate interaction site [chemical binding]; other site 649639003301 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 649639003302 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 649639003303 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 649639003304 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 649639003305 Z1 domain; Region: Z1; pfam10593 649639003306 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 649639003307 AIPR protein; Region: AIPR; pfam10592 649639003308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639003309 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 649639003310 Walker A motif; other site 649639003311 ATP binding site [chemical binding]; other site 649639003312 Walker B motif; other site 649639003313 Uncharacterized conserved protein [Function unknown]; Region: COG3410 649639003314 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 649639003315 DNA methylase; Region: N6_N4_Mtase; pfam01555 649639003316 Predicted transcriptional regulator [Transcription]; Region: COG2378 649639003317 WYL domain; Region: WYL; pfam13280 649639003318 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 649639003319 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 649639003320 metal ion-dependent adhesion site (MIDAS); other site 649639003321 SIR2-like domain; Region: SIR2_2; pfam13289 649639003322 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 649639003323 Part of AAA domain; Region: AAA_19; pfam13245 649639003324 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 649639003325 Family description; Region: UvrD_C_2; pfam13538 649639003326 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 649639003327 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 649639003328 Catalytic site [active] 649639003329 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 649639003330 Family description; Region: UvrD_C_2; pfam13538 649639003331 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 649639003332 putative active site [active] 649639003333 putative NTP binding site [chemical binding]; other site 649639003334 putative nucleic acid binding site [nucleotide binding]; other site 649639003335 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 649639003336 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 649639003337 putative active site [active] 649639003338 putative NTP binding site [chemical binding]; other site 649639003339 putative nucleic acid binding site [nucleotide binding]; other site 649639003340 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 649639003341 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 649639003342 active site 649639003343 catalytic residues [active] 649639003344 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649639003345 Interdomain contacts; other site 649639003346 Cytokine receptor motif; other site 649639003347 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649639003348 Interdomain contacts; other site 649639003349 Cytokine receptor motif; other site 649639003350 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649639003351 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 649639003352 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649639003353 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649639003354 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 649639003355 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649639003356 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 649639003357 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649639003358 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649639003359 Transposase; Region: DEDD_Tnp_IS110; pfam01548 649639003360 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 649639003361 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 649639003362 HEAT repeats; Region: HEAT_2; pfam13646 649639003363 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 649639003364 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 649639003365 ATP binding site [chemical binding]; other site 649639003366 Mg++ binding site [ion binding]; other site 649639003367 motif III; other site 649639003368 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649639003369 nucleotide binding region [chemical binding]; other site 649639003370 ATP-binding site [chemical binding]; other site 649639003371 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 649639003372 RNA binding site [nucleotide binding]; other site 649639003373 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 649639003374 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639003375 Walker A/P-loop; other site 649639003376 ATP binding site [chemical binding]; other site 649639003377 Q-loop/lid; other site 649639003378 ABC transporter signature motif; other site 649639003379 Walker B; other site 649639003380 D-loop; other site 649639003381 H-loop/switch region; other site 649639003382 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 649639003383 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 649639003384 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 649639003385 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 649639003386 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 649639003387 Peptidase family M23; Region: Peptidase_M23; pfam01551 649639003388 TraB family; Region: TraB; pfam01963 649639003389 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 649639003390 Predicted membrane protein [Function unknown]; Region: COG2311 649639003391 Protein of unknown function (DUF418); Region: DUF418; pfam04235 649639003392 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 649639003393 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 649639003394 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 649639003395 Walker A motif; other site 649639003396 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 649639003397 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 649639003398 FMN binding site [chemical binding]; other site 649639003399 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 649639003400 dimer interface [polypeptide binding]; other site 649639003401 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 649639003402 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649639003403 FeS/SAM binding site; other site 649639003404 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 649639003405 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 649639003406 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 649639003407 active site 649639003408 FMN binding site [chemical binding]; other site 649639003409 substrate binding site [chemical binding]; other site 649639003410 putative catalytic residue [active] 649639003411 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 649639003412 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 649639003413 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 649639003414 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 649639003415 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 649639003416 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649639003417 dimerization interface [polypeptide binding]; other site 649639003418 putative DNA binding site [nucleotide binding]; other site 649639003419 putative Zn2+ binding site [ion binding]; other site 649639003420 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 649639003421 putative hydrophobic ligand binding site [chemical binding]; other site 649639003422 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649639003423 Beta-lactamase; Region: Beta-lactamase; pfam00144 649639003424 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 649639003425 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 649639003426 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 649639003427 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 649639003428 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 649639003429 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 649639003430 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 649639003431 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 649639003432 DinB superfamily; Region: DinB_2; pfam12867 649639003433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649639003434 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649639003435 dimerization interface [polypeptide binding]; other site 649639003436 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 649639003437 Histidine kinase; Region: His_kinase; pfam06580 649639003438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639003439 ATP binding site [chemical binding]; other site 649639003440 Mg2+ binding site [ion binding]; other site 649639003441 G-X-G motif; other site 649639003442 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 649639003443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639003444 active site 649639003445 phosphorylation site [posttranslational modification] 649639003446 intermolecular recognition site; other site 649639003447 dimerization interface [polypeptide binding]; other site 649639003448 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649639003449 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 649639003450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639003451 dimer interface [polypeptide binding]; other site 649639003452 conserved gate region; other site 649639003453 putative PBP binding loops; other site 649639003454 ABC-ATPase subunit interface; other site 649639003455 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649639003456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639003457 dimer interface [polypeptide binding]; other site 649639003458 ABC-ATPase subunit interface; other site 649639003459 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649639003460 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649639003461 putative alpha-glucosidase; Provisional; Region: PRK10658 649639003462 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 649639003463 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 649639003464 active site 649639003465 homotrimer interface [polypeptide binding]; other site 649639003466 catalytic site [active] 649639003467 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 649639003468 Predicted integral membrane protein [Function unknown]; Region: COG5578 649639003469 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649639003470 dimerization interface [polypeptide binding]; other site 649639003471 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649639003472 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649639003473 dimer interface [polypeptide binding]; other site 649639003474 putative CheW interface [polypeptide binding]; other site 649639003475 Carbon starvation protein CstA; Region: CstA; pfam02554 649639003476 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 649639003477 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 649639003478 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 649639003479 Ferritin-like domain; Region: Ferritin; pfam00210 649639003480 ferroxidase diiron center [ion binding]; other site 649639003481 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 649639003482 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 649639003483 putative ligand binding site [chemical binding]; other site 649639003484 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 649639003485 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 649639003486 Walker A/P-loop; other site 649639003487 ATP binding site [chemical binding]; other site 649639003488 Q-loop/lid; other site 649639003489 ABC transporter signature motif; other site 649639003490 Walker B; other site 649639003491 D-loop; other site 649639003492 H-loop/switch region; other site 649639003493 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 649639003494 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 649639003495 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 649639003496 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 649639003497 TM-ABC transporter signature motif; other site 649639003498 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 649639003499 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 649639003500 intersubunit interface [polypeptide binding]; other site 649639003501 active site 649639003502 Zn2+ binding site [ion binding]; other site 649639003503 ribulokinase; Provisional; Region: PRK04123 649639003504 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 649639003505 N- and C-terminal domain interface [polypeptide binding]; other site 649639003506 active site 649639003507 MgATP binding site [chemical binding]; other site 649639003508 catalytic site [active] 649639003509 metal binding site [ion binding]; metal-binding site 649639003510 carbohydrate binding site [chemical binding]; other site 649639003511 homodimer interface [polypeptide binding]; other site 649639003512 L-arabinose isomerase; Provisional; Region: PRK02929 649639003513 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 649639003514 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 649639003515 trimer interface [polypeptide binding]; other site 649639003516 putative substrate binding site [chemical binding]; other site 649639003517 putative metal binding site [ion binding]; other site 649639003518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649639003519 DNA-binding site [nucleotide binding]; DNA binding site 649639003520 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649639003521 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 649639003522 putative dimerization interface [polypeptide binding]; other site 649639003523 putative ligand binding site [chemical binding]; other site 649639003524 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 649639003525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639003526 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649639003527 DNA binding residues [nucleotide binding] 649639003528 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649639003529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639003530 Walker A/P-loop; other site 649639003531 ATP binding site [chemical binding]; other site 649639003532 Q-loop/lid; other site 649639003533 ABC transporter signature motif; other site 649639003534 Walker B; other site 649639003535 D-loop; other site 649639003536 H-loop/switch region; other site 649639003537 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 649639003538 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 649639003539 nucleotide binding site/active site [active] 649639003540 HIT family signature motif; other site 649639003541 catalytic residue [active] 649639003542 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 649639003543 SnoaL-like domain; Region: SnoaL_3; pfam13474 649639003544 SnoaL-like domain; Region: SnoaL_2; pfam12680 649639003545 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 649639003546 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 649639003547 active site 649639003548 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 649639003549 homodimer interaction site [polypeptide binding]; other site 649639003550 cofactor binding site; other site 649639003551 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649639003552 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649639003553 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 649639003554 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; cl17559 649639003555 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 649639003556 active site 649639003557 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 649639003558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639003559 dimer interface [polypeptide binding]; other site 649639003560 conserved gate region; other site 649639003561 putative PBP binding loops; other site 649639003562 ABC-ATPase subunit interface; other site 649639003563 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 649639003564 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 649639003565 Walker A/P-loop; other site 649639003566 ATP binding site [chemical binding]; other site 649639003567 Q-loop/lid; other site 649639003568 ABC transporter signature motif; other site 649639003569 Walker B; other site 649639003570 D-loop; other site 649639003571 H-loop/switch region; other site 649639003572 NMT1-like family; Region: NMT1_2; pfam13379 649639003573 NMT1/THI5 like; Region: NMT1; pfam09084 649639003574 Isochorismatase family; Region: Isochorismatase; pfam00857 649639003575 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 649639003576 catalytic triad [active] 649639003577 conserved cis-peptide bond; other site 649639003578 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 649639003579 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 649639003580 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 649639003581 indole-3-acetamide amidohydrolase; Region: PLN02722 649639003582 Amidase; Region: Amidase; cl11426 649639003583 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 649639003584 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 649639003585 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 649639003586 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 649639003587 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 649639003588 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 649639003589 Methyltransferase domain; Region: Methyltransf_23; pfam13489 649639003590 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639003591 S-adenosylmethionine binding site [chemical binding]; other site 649639003592 hypothetical protein; Provisional; Region: PRK07758 649639003593 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 649639003594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639003595 S-adenosylmethionine binding site [chemical binding]; other site 649639003596 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 649639003597 Helix-turn-helix domain; Region: HTH_28; pfam13518 649639003598 Homeodomain-like domain; Region: HTH_23; cl17451 649639003599 putative transposase OrfB; Reviewed; Region: PHA02517 649639003600 HTH-like domain; Region: HTH_21; pfam13276 649639003601 Integrase core domain; Region: rve; pfam00665 649639003602 Integrase core domain; Region: rve_2; pfam13333 649639003603 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649639003604 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 649639003605 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 649639003606 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 649639003607 NAD(P) binding pocket [chemical binding]; other site 649639003608 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 649639003609 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 649639003610 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 649639003611 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649639003612 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 649639003613 active site 649639003614 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 649639003615 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 649639003616 DinB family; Region: DinB; cl17821 649639003617 DinB superfamily; Region: DinB_2; pfam12867 649639003618 prolyl-tRNA synthetase; Provisional; Region: PRK08661 649639003619 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 649639003620 dimer interface [polypeptide binding]; other site 649639003621 motif 1; other site 649639003622 active site 649639003623 motif 2; other site 649639003624 motif 3; other site 649639003625 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 649639003626 anticodon binding site; other site 649639003627 zinc-binding site [ion binding]; other site 649639003628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639003629 Coenzyme A binding pocket [chemical binding]; other site 649639003630 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649639003631 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649639003632 DGC domain; Region: DGC; pfam08859 649639003633 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 649639003634 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 649639003635 ligand binding site [chemical binding]; other site 649639003636 Predicted membrane protein [Function unknown]; Region: COG2323 649639003637 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 649639003638 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 649639003639 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 649639003640 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639003641 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 649639003642 DNA binding residues [nucleotide binding] 649639003643 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 649639003644 putative catalytic residues [active] 649639003645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639003646 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649639003647 putative substrate translocation pore; other site 649639003648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639003649 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 649639003650 hypothetical protein; Provisional; Region: PRK07906 649639003651 putative metal binding site [ion binding]; other site 649639003652 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 649639003653 CARDB; Region: CARDB; pfam07705 649639003654 CARDB; Region: CARDB; pfam07705 649639003655 IncA protein; Region: IncA; pfam04156 649639003656 Protein of unknown function (DUF972); Region: DUF972; pfam06156 649639003657 SEC-C motif; Region: SEC-C; pfam02810 649639003658 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 649639003659 Predicted membrane protein [Function unknown]; Region: COG2323 649639003660 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 649639003661 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 649639003662 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 649639003663 HlyD family secretion protein; Region: HlyD_3; pfam13437 649639003664 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 649639003665 Protein export membrane protein; Region: SecD_SecF; cl14618 649639003666 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 649639003667 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 649639003668 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 649639003669 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 649639003670 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649639003671 active site 649639003672 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649639003673 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639003674 Walker A/P-loop; other site 649639003675 ATP binding site [chemical binding]; other site 649639003676 Q-loop/lid; other site 649639003677 ABC transporter signature motif; other site 649639003678 Walker B; other site 649639003679 D-loop; other site 649639003680 H-loop/switch region; other site 649639003681 ABC-2 type transporter; Region: ABC2_membrane; cl17235 649639003682 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 649639003683 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 649639003684 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649639003685 Histidine kinase; Region: HisKA_3; pfam07730 649639003686 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649639003687 ATP binding site [chemical binding]; other site 649639003688 Mg2+ binding site [ion binding]; other site 649639003689 G-X-G motif; other site 649639003690 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649639003691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639003692 active site 649639003693 phosphorylation site [posttranslational modification] 649639003694 intermolecular recognition site; other site 649639003695 dimerization interface [polypeptide binding]; other site 649639003696 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649639003697 DNA binding residues [nucleotide binding] 649639003698 dimerization interface [polypeptide binding]; other site 649639003699 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 649639003700 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649639003701 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639003702 Walker A/P-loop; other site 649639003703 ATP binding site [chemical binding]; other site 649639003704 Q-loop/lid; other site 649639003705 ABC transporter signature motif; other site 649639003706 Walker B; other site 649639003707 D-loop; other site 649639003708 H-loop/switch region; other site 649639003709 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649639003710 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649639003711 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 649639003712 Walker A/P-loop; other site 649639003713 ATP binding site [chemical binding]; other site 649639003714 Q-loop/lid; other site 649639003715 ABC transporter signature motif; other site 649639003716 Walker B; other site 649639003717 D-loop; other site 649639003718 H-loop/switch region; other site 649639003719 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 649639003720 EamA-like transporter family; Region: EamA; cl17759 649639003721 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 649639003722 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 649639003723 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 649639003724 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 649639003725 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 649639003726 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 649639003727 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 649639003728 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649639003729 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 649639003730 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 649639003731 Walker A/P-loop; other site 649639003732 ATP binding site [chemical binding]; other site 649639003733 Q-loop/lid; other site 649639003734 ABC transporter signature motif; other site 649639003735 Walker B; other site 649639003736 D-loop; other site 649639003737 H-loop/switch region; other site 649639003738 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 649639003739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639003740 dimer interface [polypeptide binding]; other site 649639003741 conserved gate region; other site 649639003742 putative PBP binding loops; other site 649639003743 ABC-ATPase subunit interface; other site 649639003744 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 649639003745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 649639003746 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 649639003747 NMT1/THI5 like; Region: NMT1; pfam09084 649639003748 mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases); Region: ML_beta-AS_like; cd07568 649639003749 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 649639003750 putative active site [active] 649639003751 catalytic triad [active] 649639003752 multimer interface [polypeptide binding]; other site 649639003753 dimer interface [polypeptide binding]; other site 649639003754 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 649639003755 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 649639003756 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 649639003757 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649639003758 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 649639003759 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 649639003760 homodimer interface [polypeptide binding]; other site 649639003761 active site 649639003762 FMN binding site [chemical binding]; other site 649639003763 substrate binding site [chemical binding]; other site 649639003764 phenylhydantoinase; Validated; Region: PRK08323 649639003765 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 649639003766 tetramer interface [polypeptide binding]; other site 649639003767 active site 649639003768 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 649639003769 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 649639003770 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 649639003771 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 649639003772 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 649639003773 tetrameric interface [polypeptide binding]; other site 649639003774 NAD binding site [chemical binding]; other site 649639003775 catalytic residues [active] 649639003776 aminotransferase; Validated; Region: PRK07678 649639003777 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 649639003778 inhibitor-cofactor binding pocket; inhibition site 649639003779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639003780 catalytic residue [active] 649639003781 Nitrate and nitrite sensing; Region: NIT; pfam08376 649639003782 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 649639003783 dimerization interface [polypeptide binding]; other site 649639003784 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649639003785 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649639003786 dimer interface [polypeptide binding]; other site 649639003787 putative CheW interface [polypeptide binding]; other site 649639003788 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 649639003789 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 649639003790 putative metal binding site [ion binding]; other site 649639003791 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 649639003792 active site 649639003793 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 649639003794 high affinity sulphate transporter 1; Region: sulP; TIGR00815 649639003795 Sulfate transporter family; Region: Sulfate_transp; pfam00916 649639003796 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 649639003797 Carbonic anhydrase; Region: Pro_CA; smart00947 649639003798 active site clefts [active] 649639003799 zinc binding site [ion binding]; other site 649639003800 dimer interface [polypeptide binding]; other site 649639003801 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 649639003802 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 649639003803 active site residue [active] 649639003804 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 649639003805 CPxP motif; other site 649639003806 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 649639003807 active site residue [active] 649639003808 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 649639003809 active site residue [active] 649639003810 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 649639003811 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 649639003812 CPxP motif; other site 649639003813 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 649639003814 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 649639003815 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649639003816 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 649639003817 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 649639003818 active site residue [active] 649639003819 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 649639003820 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 649639003821 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 649639003822 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 649639003823 catalytic residues [active] 649639003824 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649639003825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639003826 active site 649639003827 phosphorylation site [posttranslational modification] 649639003828 intermolecular recognition site; other site 649639003829 dimerization interface [polypeptide binding]; other site 649639003830 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649639003831 DNA binding site [nucleotide binding] 649639003832 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649639003833 dimerization interface [polypeptide binding]; other site 649639003834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639003835 dimer interface [polypeptide binding]; other site 649639003836 phosphorylation site [posttranslational modification] 649639003837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639003838 ATP binding site [chemical binding]; other site 649639003839 Mg2+ binding site [ion binding]; other site 649639003840 G-X-G motif; other site 649639003841 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 649639003842 active site 649639003843 catalytic site [active] 649639003844 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 649639003845 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 649639003846 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 649639003847 MPT binding site; other site 649639003848 trimer interface [polypeptide binding]; other site 649639003849 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 649639003850 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 649639003851 Moco binding site; other site 649639003852 metal coordination site [ion binding]; other site 649639003853 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649639003854 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649639003855 DNA binding site [nucleotide binding] 649639003856 domain linker motif; other site 649639003857 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649639003858 dimerization interface [polypeptide binding]; other site 649639003859 ligand binding site [chemical binding]; other site 649639003860 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 649639003861 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 649639003862 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 649639003863 hypothetical protein; Validated; Region: PRK06201 649639003864 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 649639003865 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 649639003866 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 649639003867 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 649639003868 active site 649639003869 NAD binding site [chemical binding]; other site 649639003870 metal binding site [ion binding]; metal-binding site 649639003871 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 649639003872 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 649639003873 NAD(P) binding site [chemical binding]; other site 649639003874 catalytic residues [active] 649639003875 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649639003876 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649639003877 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 649639003878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639003879 dimer interface [polypeptide binding]; other site 649639003880 conserved gate region; other site 649639003881 putative PBP binding loops; other site 649639003882 ABC-ATPase subunit interface; other site 649639003883 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649639003884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639003885 dimer interface [polypeptide binding]; other site 649639003886 conserved gate region; other site 649639003887 putative PBP binding loops; other site 649639003888 ABC-ATPase subunit interface; other site 649639003889 glyoxylate reductase; Reviewed; Region: PRK13243 649639003890 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 649639003891 dimerization interface [polypeptide binding]; other site 649639003892 ligand binding site [chemical binding]; other site 649639003893 NADP binding site [chemical binding]; other site 649639003894 catalytic site [active] 649639003895 glycerate kinase; Region: TIGR00045 649639003896 Predicted integral membrane protein [Function unknown]; Region: COG5578 649639003897 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 649639003898 active site 649639003899 catalytic triad [active] 649639003900 oxyanion hole [active] 649639003901 short chain dehydrogenase; Provisional; Region: PRK06701 649639003902 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 649639003903 NAD binding site [chemical binding]; other site 649639003904 metal binding site [ion binding]; metal-binding site 649639003905 active site 649639003906 epoxyqueuosine reductase; Region: TIGR00276 649639003907 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 649639003908 4Fe-4S binding domain; Region: Fer4; pfam00037 649639003909 HEAT repeats; Region: HEAT_2; pfam13646 649639003910 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 649639003911 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 649639003912 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 649639003913 DNA binding site [nucleotide binding] 649639003914 active site 649639003915 Elongation factor TS; Region: EF_TS; pfam00889 649639003916 Putative amidase domain; Region: Amidase_6; pfam12671 649639003917 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 649639003918 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 649639003919 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 649639003920 putative active site [active] 649639003921 putative NTP binding site [chemical binding]; other site 649639003922 putative nucleic acid binding site [nucleotide binding]; other site 649639003923 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 649639003924 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 649639003925 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 649639003926 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 649639003927 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 649639003928 Transglycosylase; Region: Transgly; pfam00912 649639003929 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 649639003930 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 649639003931 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 649639003932 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 649639003933 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 649639003934 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 649639003935 Catalytic site [active] 649639003936 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 649639003937 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649639003938 dimerization interface [polypeptide binding]; other site 649639003939 ligand binding site [chemical binding]; other site 649639003940 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 649639003941 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649639003942 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649639003943 metal binding site [ion binding]; metal-binding site 649639003944 active site 649639003945 I-site; other site 649639003946 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 649639003947 Part of AAA domain; Region: AAA_19; pfam13245 649639003948 Family description; Region: UvrD_C_2; pfam13538 649639003949 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 649639003950 Carbohydrate binding module 27; Region: CBM27; pfam09212 649639003951 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 649639003952 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649639003953 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649639003954 DNA binding site [nucleotide binding] 649639003955 domain linker motif; other site 649639003956 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 649639003957 Domain of unknown function (DUF377); Region: DUF377; pfam04041 649639003958 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 649639003959 active site 649639003960 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 649639003961 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 649639003962 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 649639003963 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 649639003964 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 649639003965 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 649639003966 G1 box; other site 649639003967 putative GEF interaction site [polypeptide binding]; other site 649639003968 GTP/Mg2+ binding site [chemical binding]; other site 649639003969 Switch I region; other site 649639003970 G2 box; other site 649639003971 G3 box; other site 649639003972 Switch II region; other site 649639003973 G4 box; other site 649639003974 G5 box; other site 649639003975 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 649639003976 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 649639003977 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 649639003978 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 649639003979 dimanganese center [ion binding]; other site 649639003980 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 649639003981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639003982 active site 649639003983 phosphorylation site [posttranslational modification] 649639003984 intermolecular recognition site; other site 649639003985 dimerization interface [polypeptide binding]; other site 649639003986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 649639003987 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 649639003988 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 649639003989 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 649639003990 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 649639003991 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639003992 Coenzyme A binding pocket [chemical binding]; other site 649639003993 Predicted amidohydrolase [General function prediction only]; Region: COG0388 649639003994 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 649639003995 putative active site [active] 649639003996 catalytic triad [active] 649639003997 putative dimer interface [polypeptide binding]; other site 649639003998 Transposase; Region: DEDD_Tnp_IS110; pfam01548 649639003999 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 649639004000 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 649639004001 glycerol kinase; Provisional; Region: glpK; PRK00047 649639004002 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 649639004003 N- and C-terminal domain interface [polypeptide binding]; other site 649639004004 active site 649639004005 MgATP binding site [chemical binding]; other site 649639004006 catalytic site [active] 649639004007 metal binding site [ion binding]; metal-binding site 649639004008 glycerol binding site [chemical binding]; other site 649639004009 homotetramer interface [polypeptide binding]; other site 649639004010 homodimer interface [polypeptide binding]; other site 649639004011 FBP binding site [chemical binding]; other site 649639004012 protein IIAGlc interface [polypeptide binding]; other site 649639004013 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 649639004014 Uncharacterized conserved protein [Function unknown]; Region: COG1284 649639004015 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 649639004016 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 649639004017 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 649639004018 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 649639004019 G1 box; other site 649639004020 putative GEF interaction site [polypeptide binding]; other site 649639004021 GTP/Mg2+ binding site [chemical binding]; other site 649639004022 Switch I region; other site 649639004023 G2 box; other site 649639004024 G3 box; other site 649639004025 Switch II region; other site 649639004026 G4 box; other site 649639004027 G5 box; other site 649639004028 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 649639004029 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 649639004030 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 649639004031 substrate binding site [chemical binding]; other site 649639004032 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 649639004033 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 649639004034 substrate binding site [chemical binding]; other site 649639004035 ligand binding site [chemical binding]; other site 649639004036 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 649639004037 tartrate dehydrogenase; Region: TTC; TIGR02089 649639004038 2-isopropylmalate synthase; Validated; Region: PRK00915 649639004039 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 649639004040 active site 649639004041 catalytic residues [active] 649639004042 metal binding site [ion binding]; metal-binding site 649639004043 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 649639004044 ketol-acid reductoisomerase; Provisional; Region: PRK05479 649639004045 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 649639004046 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 649639004047 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 649639004048 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 649639004049 putative valine binding site [chemical binding]; other site 649639004050 dimer interface [polypeptide binding]; other site 649639004051 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 649639004052 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 649639004053 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 649639004054 PYR/PP interface [polypeptide binding]; other site 649639004055 dimer interface [polypeptide binding]; other site 649639004056 TPP binding site [chemical binding]; other site 649639004057 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 649639004058 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 649639004059 TPP-binding site [chemical binding]; other site 649639004060 dimer interface [polypeptide binding]; other site 649639004061 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 649639004062 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 649639004063 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 649639004064 homodimer interface [polypeptide binding]; other site 649639004065 substrate-cofactor binding pocket; other site 649639004066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639004067 catalytic residue [active] 649639004068 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 649639004069 SpoVR like protein; Region: SpoVR; pfam04293 649639004070 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 649639004071 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 649639004072 DHHA2 domain; Region: DHHA2; pfam02833 649639004073 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 649639004074 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 649639004075 Aspartyl protease; Region: Asp_protease_2; pfam13650 649639004076 inhibitor binding site; inhibition site 649639004077 catalytic motif [active] 649639004078 Catalytic residue [active] 649639004079 Active site flap [active] 649639004080 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 649639004081 TrkA-C domain; Region: TrkA_C; pfam02080 649639004082 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 649639004083 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649639004084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639004085 dimer interface [polypeptide binding]; other site 649639004086 phosphorylation site [posttranslational modification] 649639004087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639004088 ATP binding site [chemical binding]; other site 649639004089 Mg2+ binding site [ion binding]; other site 649639004090 G-X-G motif; other site 649639004091 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 649639004092 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 649639004093 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 649639004094 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 649639004095 Sulfatase; Region: Sulfatase; pfam00884 649639004096 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 649639004097 active site 649639004098 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 649639004099 L-lactate permease; Region: Lactate_perm; cl00701 649639004100 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 649639004101 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 649639004102 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649639004103 FeS/SAM binding site; other site 649639004104 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 649639004105 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649639004106 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 649639004107 Walker A/P-loop; other site 649639004108 ATP binding site [chemical binding]; other site 649639004109 Q-loop/lid; other site 649639004110 ABC transporter signature motif; other site 649639004111 Walker B; other site 649639004112 D-loop; other site 649639004113 H-loop/switch region; other site 649639004114 Predicted transcriptional regulators [Transcription]; Region: COG1725 649639004115 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649639004116 DNA-binding site [nucleotide binding]; DNA binding site 649639004117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649639004118 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649639004119 NAD(P) binding site [chemical binding]; other site 649639004120 active site 649639004121 putative rSAM target protein, CGCGG family; Region: target_X_rSAM; TIGR03995 649639004122 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 649639004123 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639004124 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649639004125 DNA binding residues [nucleotide binding] 649639004126 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 649639004127 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649639004128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639004129 Walker A/P-loop; other site 649639004130 ATP binding site [chemical binding]; other site 649639004131 Q-loop/lid; other site 649639004132 ABC transporter signature motif; other site 649639004133 Walker B; other site 649639004134 D-loop; other site 649639004135 H-loop/switch region; other site 649639004136 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649639004137 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649639004138 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 649639004139 Walker A/P-loop; other site 649639004140 ATP binding site [chemical binding]; other site 649639004141 Q-loop/lid; other site 649639004142 ABC transporter signature motif; other site 649639004143 Walker B; other site 649639004144 D-loop; other site 649639004145 H-loop/switch region; other site 649639004146 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 649639004147 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 649639004148 active site 649639004149 catalytic residues [active] 649639004150 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 649639004151 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 649639004152 DXD motif; other site 649639004153 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 649639004154 putative active site [active] 649639004155 putative metal binding site [ion binding]; other site 649639004156 Family description; Region: DsbD_2; pfam13386 649639004157 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 649639004158 HTH domain; Region: HTH_11; pfam08279 649639004159 3H domain; Region: 3H; pfam02829 649639004160 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 649639004161 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 649639004162 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649639004163 catalytic residue [active] 649639004164 L-aspartate oxidase; Provisional; Region: PRK08071 649639004165 L-aspartate oxidase; Provisional; Region: PRK06175 649639004166 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 649639004167 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 649639004168 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 649639004169 dimerization interface [polypeptide binding]; other site 649639004170 active site 649639004171 quinolinate synthetase; Provisional; Region: PRK09375 649639004172 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 649639004173 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 649639004174 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 649639004175 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 649639004176 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 649639004177 Walker A/P-loop; other site 649639004178 ATP binding site [chemical binding]; other site 649639004179 Q-loop/lid; other site 649639004180 ABC transporter signature motif; other site 649639004181 Walker B; other site 649639004182 D-loop; other site 649639004183 H-loop/switch region; other site 649639004184 TOBE domain; Region: TOBE; pfam03459 649639004185 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 649639004186 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 649639004187 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 649639004188 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 649639004189 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 649639004190 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 649639004191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 649639004192 hypothetical protein; Provisional; Region: PRK13676 649639004193 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 649639004194 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649639004195 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 649639004196 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649639004197 alpha-galactosidase; Provisional; Region: PRK15076 649639004198 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 649639004199 NAD binding site [chemical binding]; other site 649639004200 sugar binding site [chemical binding]; other site 649639004201 divalent metal binding site [ion binding]; other site 649639004202 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 649639004203 dimer interface [polypeptide binding]; other site 649639004204 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639004205 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 649639004206 active site 649639004207 motif I; other site 649639004208 motif II; other site 649639004209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639004210 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 649639004211 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 649639004212 CoenzymeA binding site [chemical binding]; other site 649639004213 subunit interaction site [polypeptide binding]; other site 649639004214 PHB binding site; other site 649639004215 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 649639004216 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 649639004217 active site 649639004218 metal binding site [ion binding]; metal-binding site 649639004219 DNA binding site [nucleotide binding] 649639004220 AAA domain; Region: AAA_23; pfam13476 649639004221 Predicted transcriptional regulators [Transcription]; Region: COG1510 649639004222 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649639004223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639004224 active site 649639004225 phosphorylation site [posttranslational modification] 649639004226 intermolecular recognition site; other site 649639004227 dimerization interface [polypeptide binding]; other site 649639004228 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649639004229 DNA binding site [nucleotide binding] 649639004230 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649639004231 HAMP domain; Region: HAMP; pfam00672 649639004232 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639004233 dimer interface [polypeptide binding]; other site 649639004234 phosphorylation site [posttranslational modification] 649639004235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639004236 ATP binding site [chemical binding]; other site 649639004237 Mg2+ binding site [ion binding]; other site 649639004238 G-X-G motif; other site 649639004239 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 649639004240 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 649639004241 generic binding surface II; other site 649639004242 generic binding surface I; other site 649639004243 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 649639004244 Zn2+ binding site [ion binding]; other site 649639004245 Mg2+ binding site [ion binding]; other site 649639004246 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 649639004247 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 649639004248 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 649639004249 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 649639004250 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 649639004251 transcriptional regulator Hpr; Provisional; Region: PRK13777 649639004252 MarR family; Region: MarR; pfam01047 649639004253 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 649639004254 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649639004255 catalytic residue [active] 649639004256 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 649639004257 HIT family signature motif; other site 649639004258 catalytic residue [active] 649639004259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639004260 putative substrate translocation pore; other site 649639004261 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649639004262 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 649639004263 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 649639004264 Walker A/P-loop; other site 649639004265 ATP binding site [chemical binding]; other site 649639004266 Q-loop/lid; other site 649639004267 ABC transporter signature motif; other site 649639004268 Walker B; other site 649639004269 D-loop; other site 649639004270 H-loop/switch region; other site 649639004271 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 649639004272 EcsC protein family; Region: EcsC; pfam12787 649639004273 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 649639004274 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 649639004275 metal binding site [ion binding]; metal-binding site 649639004276 dimer interface [polypeptide binding]; other site 649639004277 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 649639004278 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 649639004279 Transglycosylase; Region: Transgly; pfam00912 649639004280 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 649639004281 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 649639004282 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 649639004283 substrate binding site [chemical binding]; other site 649639004284 active site 649639004285 ferrochelatase; Provisional; Region: PRK12435 649639004286 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 649639004287 C-terminal domain interface [polypeptide binding]; other site 649639004288 active site 649639004289 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 649639004290 active site 649639004291 N-terminal domain interface [polypeptide binding]; other site 649639004292 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 649639004293 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 649639004294 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639004295 phosphorylation site [posttranslational modification] 649639004296 dimer interface [polypeptide binding]; other site 649639004297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639004298 ATP binding site [chemical binding]; other site 649639004299 Mg2+ binding site [ion binding]; other site 649639004300 G-X-G motif; other site 649639004301 GTPase CgtA; Reviewed; Region: obgE; PRK12297 649639004302 GTP1/OBG; Region: GTP1_OBG; pfam01018 649639004303 Obg GTPase; Region: Obg; cd01898 649639004304 G1 box; other site 649639004305 GTP/Mg2+ binding site [chemical binding]; other site 649639004306 Switch I region; other site 649639004307 G2 box; other site 649639004308 G3 box; other site 649639004309 Switch II region; other site 649639004310 G4 box; other site 649639004311 G5 box; other site 649639004312 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 649639004313 hypothetical protein; Provisional; Region: PRK04435 649639004314 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 649639004315 prephenate dehydratase; Provisional; Region: PRK11898 649639004316 Prephenate dehydratase; Region: PDT; pfam00800 649639004317 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 649639004318 putative L-Phe binding site [chemical binding]; other site 649639004319 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639004320 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 649639004321 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 649639004322 BofC C-terminal domain; Region: BofC_C; pfam08955 649639004323 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 649639004324 RuvA N terminal domain; Region: RuvA_N; pfam01330 649639004325 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 649639004326 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639004327 Walker A motif; other site 649639004328 ATP binding site [chemical binding]; other site 649639004329 Walker B motif; other site 649639004330 arginine finger; other site 649639004331 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 649639004332 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 649639004333 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 649639004334 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 649639004335 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 649639004336 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 649639004337 Preprotein translocase subunit; Region: YajC; pfam02699 649639004338 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 649639004339 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 649639004340 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 649639004341 transmembrane helices; other site 649639004342 Predicted membrane protein [Function unknown]; Region: COG2323 649639004343 stage V sporulation protein B; Region: spore_V_B; TIGR02900 649639004344 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 649639004345 Domain of unknown function (DUF368); Region: DUF368; pfam04018 649639004346 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 649639004347 protein-export membrane protein SecD; Region: secD; TIGR01129 649639004348 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 649639004349 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 649639004350 Protein export membrane protein; Region: SecD_SecF; pfam02355 649639004351 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 649639004352 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 649639004353 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 649639004354 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 649639004355 DHH family; Region: DHH; pfam01368 649639004356 DHHA1 domain; Region: DHHA1; pfam02272 649639004357 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 649639004358 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 649639004359 active site 649639004360 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 649639004361 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 649639004362 Zn2+ binding site [ion binding]; other site 649639004363 Mg2+ binding site [ion binding]; other site 649639004364 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 649639004365 synthetase active site [active] 649639004366 NTP binding site [chemical binding]; other site 649639004367 metal binding site [ion binding]; metal-binding site 649639004368 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 649639004369 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 649639004370 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 649639004371 putative active site [active] 649639004372 dimerization interface [polypeptide binding]; other site 649639004373 putative tRNAtyr binding site [nucleotide binding]; other site 649639004374 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 649639004375 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 649639004376 dimer interface [polypeptide binding]; other site 649639004377 motif 1; other site 649639004378 active site 649639004379 motif 2; other site 649639004380 motif 3; other site 649639004381 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 649639004382 anticodon binding site; other site 649639004383 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 649639004384 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 649639004385 dimer interface [polypeptide binding]; other site 649639004386 anticodon binding site; other site 649639004387 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 649639004388 homodimer interface [polypeptide binding]; other site 649639004389 motif 1; other site 649639004390 active site 649639004391 motif 2; other site 649639004392 GAD domain; Region: GAD; pfam02938 649639004393 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 649639004394 active site 649639004395 motif 3; other site 649639004396 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 649639004397 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 649639004398 recombination factor protein RarA; Reviewed; Region: PRK13342 649639004399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639004400 Walker A motif; other site 649639004401 ATP binding site [chemical binding]; other site 649639004402 Walker B motif; other site 649639004403 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 649639004404 Predicted membrane protein [Function unknown]; Region: COG2364 649639004405 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 649639004406 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 649639004407 Predicted transcriptional regulator [Transcription]; Region: COG1959 649639004408 Transcriptional regulator; Region: Rrf2; pfam02082 649639004409 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 649639004410 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 649639004411 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649639004412 catalytic residue [active] 649639004413 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 649639004414 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 649639004415 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649639004416 binding surface 649639004417 TPR motif; other site 649639004418 TPR repeat; Region: TPR_11; pfam13414 649639004419 TPR repeat; Region: TPR_11; pfam13414 649639004420 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649639004421 binding surface 649639004422 TPR motif; other site 649639004423 TPR repeat; Region: TPR_11; pfam13414 649639004424 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 649639004425 AAA domain; Region: AAA_30; pfam13604 649639004426 Family description; Region: UvrD_C_2; pfam13538 649639004427 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 649639004428 PRC-barrel domain; Region: PRC; pfam05239 649639004429 Domain of unknown function DUF20; Region: UPF0118; pfam01594 649639004430 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 649639004431 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 649639004432 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 649639004433 motif 1; other site 649639004434 active site 649639004435 motif 2; other site 649639004436 motif 3; other site 649639004437 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 649639004438 DHHA1 domain; Region: DHHA1; pfam02272 649639004439 hypothetical protein; Provisional; Region: PRK05473 649639004440 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 649639004441 hypothetical protein; Provisional; Region: PRK13678 649639004442 BCCT family transporter; Region: BCCT; pfam02028 649639004443 YceG-like family; Region: YceG; pfam02618 649639004444 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 649639004445 dimerization interface [polypeptide binding]; other site 649639004446 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 649639004447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639004448 S-adenosylmethionine binding site [chemical binding]; other site 649639004449 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 649639004450 Peptidase family U32; Region: Peptidase_U32; pfam01136 649639004451 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 649639004452 Peptidase family U32; Region: Peptidase_U32; pfam01136 649639004453 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 649639004454 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 649639004455 Sugar specificity; other site 649639004456 Pyrimidine base specificity; other site 649639004457 ATP-binding site [chemical binding]; other site 649639004458 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 649639004459 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 649639004460 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 649639004461 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 649639004462 Transposase; Region: DDE_Tnp_ISL3; pfam01610 649639004463 Predicted transcriptional regulators [Transcription]; Region: COG1725 649639004464 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649639004465 DNA-binding site [nucleotide binding]; DNA binding site 649639004466 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649639004467 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 649639004468 Walker A/P-loop; other site 649639004469 ATP binding site [chemical binding]; other site 649639004470 Q-loop/lid; other site 649639004471 ABC transporter signature motif; other site 649639004472 Walker B; other site 649639004473 D-loop; other site 649639004474 H-loop/switch region; other site 649639004475 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 649639004476 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 649639004477 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 649639004478 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 649639004479 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 649639004480 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 649639004481 YrhC-like protein; Region: YrhC; pfam14143 649639004482 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 649639004483 putative active site [active] 649639004484 putative CoA binding site [chemical binding]; other site 649639004485 nudix motif; other site 649639004486 metal binding site [ion binding]; metal-binding site 649639004487 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 649639004488 regulatory protein interface [polypeptide binding]; other site 649639004489 active site 649639004490 regulatory phosphorylation site [posttranslational modification]; other site 649639004491 PRC-barrel domain; Region: PRC; pfam05239 649639004492 Methyltransferase domain; Region: Methyltransf_23; pfam13489 649639004493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639004494 S-adenosylmethionine binding site [chemical binding]; other site 649639004495 sporulation sigma factor SigK; Reviewed; Region: PRK05803 649639004496 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639004497 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649639004498 DNA binding residues [nucleotide binding] 649639004499 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 649639004500 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 649639004501 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 649639004502 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 649639004503 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 649639004504 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 649639004505 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 649639004506 Zn2+ binding site [ion binding]; other site 649639004507 Mg2+ binding site [ion binding]; other site 649639004508 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649639004509 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649639004510 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 649639004511 DHH family; Region: DHH; pfam01368 649639004512 DHHA1 domain; Region: DHHA1; pfam02272 649639004513 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 649639004514 FOG: CBS domain [General function prediction only]; Region: COG0517 649639004515 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 649639004516 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 649639004517 active site 649639004518 NTP binding site [chemical binding]; other site 649639004519 metal binding triad [ion binding]; metal-binding site 649639004520 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 649639004521 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 649639004522 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 649639004523 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 649639004524 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 649639004525 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 649639004526 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 649639004527 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 649639004528 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 649639004529 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 649639004530 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 649639004531 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 649639004532 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 649639004533 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 649639004534 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 649639004535 Sporulation inhibitor A; Region: Sda; pfam08970 649639004536 GTPase YqeH; Provisional; Region: PRK13796 649639004537 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 649639004538 GTP/Mg2+ binding site [chemical binding]; other site 649639004539 G4 box; other site 649639004540 G5 box; other site 649639004541 G1 box; other site 649639004542 Switch I region; other site 649639004543 G2 box; other site 649639004544 G3 box; other site 649639004545 Switch II region; other site 649639004546 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 649639004547 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 649639004548 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 649639004549 shikimate binding site; other site 649639004550 NAD(P) binding site [chemical binding]; other site 649639004551 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 649639004552 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 649639004553 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 649639004554 active site 649639004555 (T/H)XGH motif; other site 649639004556 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 649639004557 Zn2+ binding site [ion binding]; other site 649639004558 Mg2+ binding site [ion binding]; other site 649639004559 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 649639004560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639004561 S-adenosylmethionine binding site [chemical binding]; other site 649639004562 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 649639004563 late competence protein ComER; Validated; Region: PRK07680 649639004564 SLBB domain; Region: SLBB; pfam10531 649639004565 comEA protein; Region: comE; TIGR01259 649639004566 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 649639004567 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 649639004568 catalytic motif [active] 649639004569 Zn binding site [ion binding]; other site 649639004570 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 649639004571 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 649639004572 Competence protein; Region: Competence; pfam03772 649639004573 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 649639004574 YqzM-like protein; Region: YqzM; pfam14141 649639004575 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 649639004576 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 649639004577 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 649639004578 germination protease; Provisional; Region: PRK02858 649639004579 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 649639004580 stage II sporulation protein P; Region: spore_II_P; TIGR02867 649639004581 GTP-binding protein LepA; Provisional; Region: PRK05433 649639004582 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 649639004583 G1 box; other site 649639004584 putative GEF interaction site [polypeptide binding]; other site 649639004585 GTP/Mg2+ binding site [chemical binding]; other site 649639004586 Switch I region; other site 649639004587 G2 box; other site 649639004588 G3 box; other site 649639004589 Switch II region; other site 649639004590 G4 box; other site 649639004591 G5 box; other site 649639004592 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 649639004593 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 649639004594 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 649639004595 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 649639004596 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649639004597 HemN C-terminal domain; Region: HemN_C; pfam06969 649639004598 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 649639004599 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 649639004600 heat shock protein GrpE; Provisional; Region: PRK14140 649639004601 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 649639004602 dimer interface [polypeptide binding]; other site 649639004603 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 649639004604 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 649639004605 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 649639004606 nucleotide binding site [chemical binding]; other site 649639004607 NEF interaction site [polypeptide binding]; other site 649639004608 SBD interface [polypeptide binding]; other site 649639004609 chaperone protein DnaJ; Provisional; Region: PRK14280 649639004610 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 649639004611 HSP70 interaction site [polypeptide binding]; other site 649639004612 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 649639004613 substrate binding site [polypeptide binding]; other site 649639004614 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 649639004615 Zn binding sites [ion binding]; other site 649639004616 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 649639004617 dimer interface [polypeptide binding]; other site 649639004618 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 649639004619 RNA methyltransferase, RsmE family; Region: TIGR00046 649639004620 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 649639004621 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 649639004622 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 649639004623 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649639004624 FeS/SAM binding site; other site 649639004625 TRAM domain; Region: TRAM; cl01282 649639004626 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 649639004627 intersubunit interface [polypeptide binding]; other site 649639004628 active site 649639004629 catalytic residue [active] 649639004630 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 649639004631 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 649639004632 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 649639004633 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 649639004634 Yqey-like protein; Region: YqeY; pfam09424 649639004635 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 649639004636 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 649639004637 dimer interface [polypeptide binding]; other site 649639004638 active site residues [active] 649639004639 hypothetical protein; Provisional; Region: PRK13665 649639004640 YabP family; Region: YabP; cl06766 649639004641 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 649639004642 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 649639004643 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 649639004644 PhoH-like protein; Region: PhoH; pfam02562 649639004645 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 649639004646 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 649639004647 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 649639004648 Zn2+ binding site [ion binding]; other site 649639004649 Mg2+ binding site [ion binding]; other site 649639004650 metal-binding heat shock protein; Provisional; Region: PRK00016 649639004651 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 649639004652 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 649639004653 active site 649639004654 catalytic motif [active] 649639004655 Zn binding site [ion binding]; other site 649639004656 GTPase Era; Reviewed; Region: era; PRK00089 649639004657 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 649639004658 G1 box; other site 649639004659 GTP/Mg2+ binding site [chemical binding]; other site 649639004660 Switch I region; other site 649639004661 G2 box; other site 649639004662 Switch II region; other site 649639004663 G3 box; other site 649639004664 G4 box; other site 649639004665 G5 box; other site 649639004666 KH domain; Region: KH_2; pfam07650 649639004667 YqzL-like protein; Region: YqzL; pfam14006 649639004668 Recombination protein O N terminal; Region: RecO_N; pfam11967 649639004669 DNA repair protein RecO; Region: reco; TIGR00613 649639004670 Recombination protein O C terminal; Region: RecO_C; pfam02565 649639004671 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 649639004672 dimer interface [polypeptide binding]; other site 649639004673 motif 1; other site 649639004674 active site 649639004675 motif 2; other site 649639004676 motif 3; other site 649639004677 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 649639004678 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 649639004679 PEP synthetase regulatory protein; Provisional; Region: PRK05339 649639004680 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 649639004681 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 649639004682 putative active site [active] 649639004683 putative NTP binding site [chemical binding]; other site 649639004684 putative nucleic acid binding site [nucleotide binding]; other site 649639004685 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 649639004686 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 649639004687 DNA primase; Validated; Region: dnaG; PRK05667 649639004688 CHC2 zinc finger; Region: zf-CHC2; pfam01807 649639004689 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 649639004690 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 649639004691 active site 649639004692 metal binding site [ion binding]; metal-binding site 649639004693 interdomain interaction site; other site 649639004694 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 649639004695 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 649639004696 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 649639004697 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 649639004698 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639004699 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 649639004700 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649639004701 DNA binding residues [nucleotide binding] 649639004702 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 649639004703 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 649639004704 active site 649639004705 catalytic site [active] 649639004706 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 649639004707 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 649639004708 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 649639004709 Family of unknown function (DUF633); Region: DUF633; pfam04816 649639004710 Uncharacterized conserved protein [Function unknown]; Region: COG0327 649639004711 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 649639004712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 649639004713 Uncharacterized conserved protein [Function unknown]; Region: COG0327 649639004714 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 649639004715 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 649639004716 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 649639004717 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 649639004718 YqfQ-like protein; Region: YqfQ; pfam14181 649639004719 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 649639004720 DEAD-like helicases superfamily; Region: DEXDc; smart00487 649639004721 ATP binding site [chemical binding]; other site 649639004722 Mg++ binding site [ion binding]; other site 649639004723 motif III; other site 649639004724 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649639004725 nucleotide binding region [chemical binding]; other site 649639004726 ATP-binding site [chemical binding]; other site 649639004727 endonuclease IV; Provisional; Region: PRK01060 649639004728 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 649639004729 AP (apurinic/apyrimidinic) site pocket; other site 649639004730 DNA interaction; other site 649639004731 Metal-binding active site; metal-binding site 649639004732 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 649639004733 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 649639004734 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 649639004735 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 649639004736 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 649639004737 ABC-ATPase subunit interface; other site 649639004738 dimer interface [polypeptide binding]; other site 649639004739 putative PBP binding regions; other site 649639004740 polyphosphate kinase; Provisional; Region: PRK05443 649639004741 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 649639004742 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 649639004743 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 649639004744 putative domain interface [polypeptide binding]; other site 649639004745 putative active site [active] 649639004746 catalytic site [active] 649639004747 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 649639004748 putative domain interface [polypeptide binding]; other site 649639004749 putative active site [active] 649639004750 catalytic site [active] 649639004751 exopolyphosphatase; Region: exo_poly_only; TIGR03706 649639004752 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 649639004753 nucleotide binding site [chemical binding]; other site 649639004754 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 649639004755 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 649639004756 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 649639004757 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 649639004758 ABC-ATPase subunit interface; other site 649639004759 dimer interface [polypeptide binding]; other site 649639004760 putative PBP binding regions; other site 649639004761 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 649639004762 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 649639004763 ABC-ATPase subunit interface; other site 649639004764 dimer interface [polypeptide binding]; other site 649639004765 putative PBP binding regions; other site 649639004766 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 649639004767 metal binding site 2 [ion binding]; metal-binding site 649639004768 putative DNA binding helix; other site 649639004769 metal binding site 1 [ion binding]; metal-binding site 649639004770 dimer interface [polypeptide binding]; other site 649639004771 structural Zn2+ binding site [ion binding]; other site 649639004772 Uncharacterized conserved protein [Function unknown]; Region: COG5663 649639004773 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 649639004774 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 649639004775 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 649639004776 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 649639004777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639004778 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649639004779 putative substrate translocation pore; other site 649639004780 Predicted secreted protein [Function unknown]; Region: COG4086 649639004781 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 649639004782 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 649639004783 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649639004784 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649639004785 non-specific DNA binding site [nucleotide binding]; other site 649639004786 salt bridge; other site 649639004787 sequence-specific DNA binding site [nucleotide binding]; other site 649639004788 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649639004789 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649639004790 non-specific DNA binding site [nucleotide binding]; other site 649639004791 salt bridge; other site 649639004792 sequence-specific DNA binding site [nucleotide binding]; other site 649639004793 Anti-repressor SinI; Region: SinI; pfam08671 649639004794 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 649639004795 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 649639004796 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 649639004797 PhoU domain; Region: PhoU; pfam01895 649639004798 PhoU domain; Region: PhoU; pfam01895 649639004799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 649639004800 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 649639004801 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 649639004802 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 649639004803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639004804 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649639004805 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 649639004806 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 649639004807 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 649639004808 YceG-like family; Region: YceG; pfam02618 649639004809 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 649639004810 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 649639004811 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 649639004812 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 649639004813 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 649639004814 NAD binding site [chemical binding]; other site 649639004815 dimer interface [polypeptide binding]; other site 649639004816 tetramer (dimer of dimers) interface [polypeptide binding]; other site 649639004817 substrate binding site [chemical binding]; other site 649639004818 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 649639004819 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639004820 active site 649639004821 motif I; other site 649639004822 motif II; other site 649639004823 Rhomboid family; Region: Rhomboid; pfam01694 649639004824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649639004825 binding surface 649639004826 Tetratricopeptide repeat; Region: TPR_16; pfam13432 649639004827 TPR motif; other site 649639004828 TPR repeat; Region: TPR_11; pfam13414 649639004829 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 649639004830 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 649639004831 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 649639004832 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 649639004833 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 649639004834 nucleotide binding site [chemical binding]; other site 649639004835 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 649639004836 Domain of unknown function DUF77; Region: DUF77; pfam01910 649639004837 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 649639004838 Uncharacterized conserved protein [Function unknown]; Region: COG1565 649639004839 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 649639004840 Helix-turn-helix domain; Region: HTH_20; pfam12840 649639004841 putative DNA binding site [nucleotide binding]; other site 649639004842 Predicted transcriptional regulator [Transcription]; Region: COG2345 649639004843 putative Zn2+ binding site [ion binding]; other site 649639004844 YtxH-like protein; Region: YtxH; pfam12732 649639004845 Type II/IV secretion system protein; Region: T2SE; pfam00437 649639004846 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 649639004847 Walker A motif; other site 649639004848 ATP binding site [chemical binding]; other site 649639004849 Walker B motif; other site 649639004850 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 649639004851 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 649639004852 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 649639004853 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 649639004854 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 649639004855 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 649639004856 ComG operon protein 7; Region: ComGG; pfam14173 649639004857 shikimate kinase; Reviewed; Region: aroK; PRK00131 649639004858 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 649639004859 ADP binding site [chemical binding]; other site 649639004860 magnesium binding site [ion binding]; other site 649639004861 putative shikimate binding site; other site 649639004862 YqzE-like protein; Region: YqzE; pfam14038 649639004863 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 649639004864 DEAD-like helicases superfamily; Region: DEXDc; smart00487 649639004865 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649639004866 ATP binding site [chemical binding]; other site 649639004867 putative Mg++ binding site [ion binding]; other site 649639004868 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649639004869 nucleotide binding region [chemical binding]; other site 649639004870 ATP-binding site [chemical binding]; other site 649639004871 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 649639004872 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 649639004873 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 649639004874 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 649639004875 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 649639004876 tetramer interface [polypeptide binding]; other site 649639004877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639004878 catalytic residue [active] 649639004879 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 649639004880 tetramer interface [polypeptide binding]; other site 649639004881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639004882 catalytic residue [active] 649639004883 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 649639004884 active site residue [active] 649639004885 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 649639004886 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08115 649639004887 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 649639004888 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 649639004889 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 649639004890 active site 649639004891 manganese transport transcriptional regulator; Provisional; Region: PRK03902 649639004892 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 649639004893 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 649639004894 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 649639004895 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 649639004896 active site 649639004897 nucleophile elbow; other site 649639004898 Conserved membrane protein YqhR; Region: YqhR; pfam11085 649639004899 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 649639004900 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 649639004901 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 649639004902 active site 649639004903 elongation factor P; Validated; Region: PRK00529 649639004904 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 649639004905 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 649639004906 RNA binding site [nucleotide binding]; other site 649639004907 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 649639004908 RNA binding site [nucleotide binding]; other site 649639004909 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 649639004910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639004911 Walker A motif; other site 649639004912 ATP binding site [chemical binding]; other site 649639004913 Walker B motif; other site 649639004914 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 649639004915 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 649639004916 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 649639004917 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 649639004918 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 649639004919 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 649639004920 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 649639004921 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 649639004922 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 649639004923 carboxyltransferase (CT) interaction site; other site 649639004924 biotinylation site [posttranslational modification]; other site 649639004925 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 649639004926 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 649639004927 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 649639004928 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 649639004929 Asp23 family; Region: Asp23; pfam03780 649639004930 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 649639004931 putative RNA binding site [nucleotide binding]; other site 649639004932 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 649639004933 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 649639004934 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 649639004935 homodimer interface [polypeptide binding]; other site 649639004936 NADP binding site [chemical binding]; other site 649639004937 substrate binding site [chemical binding]; other site 649639004938 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 649639004939 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 649639004940 generic binding surface II; other site 649639004941 generic binding surface I; other site 649639004942 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 649639004943 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 649639004944 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 649639004945 substrate binding pocket [chemical binding]; other site 649639004946 chain length determination region; other site 649639004947 substrate-Mg2+ binding site; other site 649639004948 catalytic residues [active] 649639004949 aspartate-rich region 1; other site 649639004950 active site lid residues [active] 649639004951 aspartate-rich region 2; other site 649639004952 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 649639004953 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 649639004954 TPP-binding site; other site 649639004955 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 649639004956 PYR/PP interface [polypeptide binding]; other site 649639004957 dimer interface [polypeptide binding]; other site 649639004958 TPP binding site [chemical binding]; other site 649639004959 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 649639004960 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 649639004961 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 649639004962 RNA binding surface [nucleotide binding]; other site 649639004963 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 649639004964 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 649639004965 arginine repressor; Provisional; Region: PRK04280 649639004966 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 649639004967 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 649639004968 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 649639004969 Walker A/P-loop; other site 649639004970 ATP binding site [chemical binding]; other site 649639004971 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 649639004972 ABC transporter signature motif; other site 649639004973 Walker B; other site 649639004974 D-loop; other site 649639004975 H-loop/switch region; other site 649639004976 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 649639004977 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 649639004978 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 649639004979 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 649639004980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639004981 active site 649639004982 phosphorylation site [posttranslational modification] 649639004983 intermolecular recognition site; other site 649639004984 dimerization interface [polypeptide binding]; other site 649639004985 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 649639004986 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 649639004987 Thiamine pyrophosphokinase; Region: TPK; cl08415 649639004988 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 649639004989 Ligand binding site; other site 649639004990 Putative Catalytic site; other site 649639004991 DXD motif; other site 649639004992 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 649639004993 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 649639004994 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649639004995 putative active site [active] 649639004996 heme pocket [chemical binding]; other site 649639004997 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649639004998 putative active site [active] 649639004999 heme pocket [chemical binding]; other site 649639005000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639005001 Walker A motif; other site 649639005002 ATP binding site [chemical binding]; other site 649639005003 Walker B motif; other site 649639005004 arginine finger; other site 649639005005 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 649639005006 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 649639005007 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 649639005008 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 649639005009 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 649639005010 NAD binding site [chemical binding]; other site 649639005011 Phe binding site; other site 649639005012 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 649639005013 nucleotide binding site [chemical binding]; other site 649639005014 Acetokinase family; Region: Acetate_kinase; cl17229 649639005015 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 649639005016 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 649639005017 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649639005018 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 649639005019 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 649639005020 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 649639005021 tetramer interface [polypeptide binding]; other site 649639005022 TPP-binding site [chemical binding]; other site 649639005023 heterodimer interface [polypeptide binding]; other site 649639005024 phosphorylation loop region [posttranslational modification] 649639005025 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 649639005026 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 649639005027 alpha subunit interface [polypeptide binding]; other site 649639005028 TPP binding site [chemical binding]; other site 649639005029 heterodimer interface [polypeptide binding]; other site 649639005030 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 649639005031 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 649639005032 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 649639005033 E3 interaction surface; other site 649639005034 lipoyl attachment site [posttranslational modification]; other site 649639005035 e3 binding domain; Region: E3_binding; pfam02817 649639005036 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 649639005037 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 649639005038 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 649639005039 intersubunit interface [polypeptide binding]; other site 649639005040 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 649639005041 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 649639005042 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 649639005043 Predicted membrane protein [Function unknown]; Region: COG4129 649639005044 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 649639005045 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 649639005046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 649639005047 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 649639005048 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 649639005049 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 649639005050 B12 binding site [chemical binding]; other site 649639005051 cobalt ligand [ion binding]; other site 649639005052 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649639005053 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 649639005054 dimer interface [polypeptide binding]; other site 649639005055 substrate binding site [chemical binding]; other site 649639005056 metal binding site [ion binding]; metal-binding site 649639005057 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 649639005058 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 649639005059 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 649639005060 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 649639005061 peptidase T-like protein; Region: PepT-like; TIGR01883 649639005062 metal binding site [ion binding]; metal-binding site 649639005063 putative dimer interface [polypeptide binding]; other site 649639005064 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 649639005065 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 649639005066 substrate binding pocket [chemical binding]; other site 649639005067 membrane-bound complex binding site; other site 649639005068 DNA polymerase IV; Validated; Region: PRK01810 649639005069 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 649639005070 active site 649639005071 DNA binding site [nucleotide binding] 649639005072 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 649639005073 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 649639005074 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 649639005075 Flagellar protein FliS; Region: FliS; cl00654 649639005076 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 649639005077 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 649639005078 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 649639005079 Protein of unknown function (DUF327); Region: DUF327; pfam03885 649639005080 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 649639005081 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 649639005082 putative substrate binding site [chemical binding]; other site 649639005083 putative ATP binding site [chemical binding]; other site 649639005084 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 649639005085 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 649639005086 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 649639005087 active site 649639005088 FMN binding site [chemical binding]; other site 649639005089 substrate binding site [chemical binding]; other site 649639005090 homotetramer interface [polypeptide binding]; other site 649639005091 catalytic residue [active] 649639005092 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 649639005093 FOG: CBS domain [General function prediction only]; Region: COG0517 649639005094 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 649639005095 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639005096 Coenzyme A binding pocket [chemical binding]; other site 649639005097 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 649639005098 NodB motif; other site 649639005099 putative active site [active] 649639005100 putative catalytic site [active] 649639005101 Zn binding site [ion binding]; other site 649639005102 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 649639005103 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649639005104 DNA binding residues [nucleotide binding] 649639005105 putative dimer interface [polypeptide binding]; other site 649639005106 Ion transport protein; Region: Ion_trans; pfam00520 649639005107 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 649639005108 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 649639005109 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 649639005110 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 649639005111 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 649639005112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649639005113 NAD(P) binding site [chemical binding]; other site 649639005114 active site 649639005115 DNA polymerase IV; Reviewed; Region: PRK03103 649639005116 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 649639005117 active site 649639005118 DNA binding site [nucleotide binding] 649639005119 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 649639005120 YolD-like protein; Region: YolD; pfam08863 649639005121 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 649639005122 Low molecular weight phosphatase family; Region: LMWPc; cd00115 649639005123 active site 649639005124 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 649639005125 active site 649639005126 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 649639005127 dimer interface [polypeptide binding]; other site 649639005128 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 649639005129 Ligand Binding Site [chemical binding]; other site 649639005130 Molecular Tunnel; other site 649639005131 phytoene desaturase; Region: crtI_fam; TIGR02734 649639005132 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 649639005133 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 649639005134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649639005135 NAD(P) binding site [chemical binding]; other site 649639005136 active site 649639005137 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 649639005138 HPr interaction site; other site 649639005139 glycerol kinase (GK) interaction site [polypeptide binding]; other site 649639005140 active site 649639005141 phosphorylation site [posttranslational modification] 649639005142 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 649639005143 Predicted permease; Region: DUF318; pfam03773 649639005144 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 649639005145 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649639005146 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649639005147 active site 649639005148 catalytic tetrad [active] 649639005149 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 649639005150 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 649639005151 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 649639005152 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 649639005153 dimer interface [polypeptide binding]; other site 649639005154 ADP-ribose binding site [chemical binding]; other site 649639005155 active site 649639005156 nudix motif; other site 649639005157 metal binding site [ion binding]; metal-binding site 649639005158 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 649639005159 stage II sporulation protein M; Region: spo_II_M; TIGR02831 649639005160 ferric uptake regulator; Provisional; Region: fur; PRK09462 649639005161 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 649639005162 metal binding site 2 [ion binding]; metal-binding site 649639005163 putative DNA binding helix; other site 649639005164 metal binding site 1 [ion binding]; metal-binding site 649639005165 dimer interface [polypeptide binding]; other site 649639005166 structural Zn2+ binding site [ion binding]; other site 649639005167 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 649639005168 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 649639005169 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 649639005170 active site 649639005171 Int/Topo IB signature motif; other site 649639005172 phosphopentomutase; Provisional; Region: PRK05362 649639005173 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 649639005174 purine nucleoside phosphorylase; Provisional; Region: PRK08202 649639005175 purine nucleoside phosphorylase; Provisional; Region: PRK08202 649639005176 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 649639005177 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 649639005178 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 649639005179 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 649639005180 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 649639005181 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 649639005182 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 649639005183 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649639005184 anti sigma factor interaction site; other site 649639005185 regulatory phosphorylation site [posttranslational modification]; other site 649639005186 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 649639005187 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639005188 ATP binding site [chemical binding]; other site 649639005189 Mg2+ binding site [ion binding]; other site 649639005190 G-X-G motif; other site 649639005191 sporulation sigma factor SigF; Validated; Region: PRK05572 649639005192 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639005193 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 649639005194 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649639005195 DNA binding residues [nucleotide binding] 649639005196 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 649639005197 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 649639005198 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 649639005199 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 649639005200 diaminopimelate decarboxylase; Region: lysA; TIGR01048 649639005201 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 649639005202 active site 649639005203 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 649639005204 substrate binding site [chemical binding]; other site 649639005205 catalytic residues [active] 649639005206 dimer interface [polypeptide binding]; other site 649639005207 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 649639005208 active site 649639005209 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 649639005210 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 649639005211 catalytic motif [active] 649639005212 Zn binding site [ion binding]; other site 649639005213 RibD C-terminal domain; Region: RibD_C; cl17279 649639005214 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 649639005215 Lumazine binding domain; Region: Lum_binding; pfam00677 649639005216 Lumazine binding domain; Region: Lum_binding; pfam00677 649639005217 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 649639005218 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 649639005219 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 649639005220 dimerization interface [polypeptide binding]; other site 649639005221 active site 649639005222 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 649639005223 homopentamer interface [polypeptide binding]; other site 649639005224 active site 649639005225 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 649639005226 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 649639005227 putative active site [active] 649639005228 putative NTP binding site [chemical binding]; other site 649639005229 putative nucleic acid binding site [nucleotide binding]; other site 649639005230 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 649639005231 Domain of unknown function (DUF309); Region: DUF309; pfam03745 649639005232 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 649639005233 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 649639005234 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 649639005235 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 649639005236 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 649639005237 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 649639005238 Predicted membrane protein [Function unknown]; Region: COG2323 649639005239 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 649639005240 SpoVA protein; Region: SpoVA; cl04298 649639005241 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 649639005242 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 649639005243 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 649639005244 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 649639005245 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 649639005246 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 649639005247 RNA binding surface [nucleotide binding]; other site 649639005248 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 649639005249 active site 649639005250 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 649639005251 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 649639005252 catalytic residues [active] 649639005253 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 649639005254 ResB-like family; Region: ResB; pfam05140 649639005255 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 649639005256 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 649639005257 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649639005258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639005259 active site 649639005260 phosphorylation site [posttranslational modification] 649639005261 intermolecular recognition site; other site 649639005262 dimerization interface [polypeptide binding]; other site 649639005263 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649639005264 DNA binding site [nucleotide binding] 649639005265 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 649639005266 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649639005267 dimerization interface [polypeptide binding]; other site 649639005268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639005269 dimer interface [polypeptide binding]; other site 649639005270 phosphorylation site [posttranslational modification] 649639005271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639005272 ATP binding site [chemical binding]; other site 649639005273 Mg2+ binding site [ion binding]; other site 649639005274 G-X-G motif; other site 649639005275 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 649639005276 SurA N-terminal domain; Region: SurA_N_3; pfam13624 649639005277 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639005278 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 649639005279 putative active site [active] 649639005280 Zn binding site [ion binding]; other site 649639005281 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 649639005282 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 649639005283 ligand binding site [chemical binding]; other site 649639005284 flexible hinge region; other site 649639005285 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 649639005286 putative switch regulator; other site 649639005287 non-specific DNA interactions [nucleotide binding]; other site 649639005288 DNA binding site [nucleotide binding] 649639005289 sequence specific DNA binding site [nucleotide binding]; other site 649639005290 putative cAMP binding site [chemical binding]; other site 649639005291 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 649639005292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 649639005293 DEAD-like helicases superfamily; Region: DEXDc; smart00487 649639005294 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649639005295 ATP binding site [chemical binding]; other site 649639005296 putative Mg++ binding site [ion binding]; other site 649639005297 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649639005298 nucleotide binding region [chemical binding]; other site 649639005299 ATP-binding site [chemical binding]; other site 649639005300 CAAX protease self-immunity; Region: Abi; pfam02517 649639005301 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 649639005302 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 649639005303 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 649639005304 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649639005305 DNA binding residues [nucleotide binding] 649639005306 B12 binding domain; Region: B12-binding_2; pfam02607 649639005307 B12 binding domain; Region: B12-binding; pfam02310 649639005308 B12 binding site [chemical binding]; other site 649639005309 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 649639005310 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 649639005311 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 649639005312 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649639005313 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 649639005314 active site 649639005315 homotetramer interface [polypeptide binding]; other site 649639005316 homodimer interface [polypeptide binding]; other site 649639005317 Protease prsW family; Region: PrsW-protease; pfam13367 649639005318 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649639005319 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 649639005320 germination protein YpeB; Region: spore_YpeB; TIGR02889 649639005321 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 649639005322 Flagellar protein YcgR; Region: YcgR_2; pfam12945 649639005323 PilZ domain; Region: PilZ; pfam07238 649639005324 cytidylate kinase; Provisional; Region: cmk; PRK00023 649639005325 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 649639005326 CMP-binding site; other site 649639005327 The sites determining sugar specificity; other site 649639005328 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 649639005329 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 649639005330 putative acyl-acceptor binding pocket; other site 649639005331 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 649639005332 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 649639005333 RNA binding site [nucleotide binding]; other site 649639005334 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 649639005335 RNA binding site [nucleotide binding]; other site 649639005336 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 649639005337 RNA binding site [nucleotide binding]; other site 649639005338 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 649639005339 RNA binding site [nucleotide binding]; other site 649639005340 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 649639005341 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 649639005342 homotetramer interface [polypeptide binding]; other site 649639005343 FMN binding site [chemical binding]; other site 649639005344 homodimer contacts [polypeptide binding]; other site 649639005345 putative active site [active] 649639005346 putative substrate binding site [chemical binding]; other site 649639005347 YpzI-like protein; Region: YpzI; pfam14140 649639005348 GTP-binding protein Der; Reviewed; Region: PRK00093 649639005349 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 649639005350 G1 box; other site 649639005351 GTP/Mg2+ binding site [chemical binding]; other site 649639005352 Switch I region; other site 649639005353 G2 box; other site 649639005354 Switch II region; other site 649639005355 G3 box; other site 649639005356 G4 box; other site 649639005357 G5 box; other site 649639005358 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 649639005359 G1 box; other site 649639005360 GTP/Mg2+ binding site [chemical binding]; other site 649639005361 Switch I region; other site 649639005362 G2 box; other site 649639005363 G3 box; other site 649639005364 Switch II region; other site 649639005365 G4 box; other site 649639005366 G5 box; other site 649639005367 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 649639005368 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 649639005369 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 649639005370 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 649639005371 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 649639005372 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 649639005373 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 649639005374 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 649639005375 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 649639005376 IHF dimer interface [polypeptide binding]; other site 649639005377 IHF - DNA interface [nucleotide binding]; other site 649639005378 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 649639005379 homodecamer interface [polypeptide binding]; other site 649639005380 GTP cyclohydrolase I; Provisional; Region: PLN03044 649639005381 active site 649639005382 putative catalytic site residues [active] 649639005383 zinc binding site [ion binding]; other site 649639005384 GTP-CH-I/GFRP interaction surface; other site 649639005385 transcription attenuation protein MtrB; Provisional; Region: PRK13251 649639005386 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 649639005387 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 649639005388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639005389 S-adenosylmethionine binding site [chemical binding]; other site 649639005390 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 649639005391 UbiA prenyltransferase family; Region: UbiA; pfam01040 649639005392 Flavoprotein; Region: Flavoprotein; pfam02441 649639005393 aromatic acid decarboxylase; Validated; Region: PRK05920 649639005394 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 649639005395 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 649639005396 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 649639005397 substrate binding pocket [chemical binding]; other site 649639005398 chain length determination region; other site 649639005399 substrate-Mg2+ binding site; other site 649639005400 catalytic residues [active] 649639005401 aspartate-rich region 1; other site 649639005402 active site lid residues [active] 649639005403 aspartate-rich region 2; other site 649639005404 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 649639005405 active site 649639005406 multimer interface [polypeptide binding]; other site 649639005407 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 649639005408 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 649639005409 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 649639005410 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 649639005411 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 649639005412 Tetramer interface [polypeptide binding]; other site 649639005413 active site 649639005414 FMN-binding site [chemical binding]; other site 649639005415 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 649639005416 active site 649639005417 dimer interface [polypeptide binding]; other site 649639005418 metal binding site [ion binding]; metal-binding site 649639005419 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 649639005420 homotrimer interaction site [polypeptide binding]; other site 649639005421 active site 649639005422 anthranilate synthase component I; Provisional; Region: PRK13569 649639005423 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 649639005424 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 649639005425 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 649639005426 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 649639005427 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 649639005428 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 649639005429 active site 649639005430 ribulose/triose binding site [chemical binding]; other site 649639005431 phosphate binding site [ion binding]; other site 649639005432 substrate (anthranilate) binding pocket [chemical binding]; other site 649639005433 product (indole) binding pocket [chemical binding]; other site 649639005434 bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta; Provisional; Region: PRK13803 649639005435 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 649639005436 active site 649639005437 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 649639005438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639005439 catalytic residue [active] 649639005440 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 649639005441 substrate binding site [chemical binding]; other site 649639005442 active site 649639005443 catalytic residues [active] 649639005444 heterodimer interface [polypeptide binding]; other site 649639005445 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 649639005446 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 649639005447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639005448 homodimer interface [polypeptide binding]; other site 649639005449 catalytic residue [active] 649639005450 prephenate dehydrogenase; Validated; Region: PRK06545 649639005451 prephenate dehydrogenase; Validated; Region: PRK08507 649639005452 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 649639005453 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 649639005454 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 649639005455 hinge; other site 649639005456 active site 649639005457 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649639005458 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649639005459 TPR motif; other site 649639005460 binding surface 649639005461 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649639005462 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649639005463 binding surface 649639005464 TPR motif; other site 649639005465 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 649639005466 binding surface 649639005467 TPR motif; other site 649639005468 hypothetical protein; Provisional; Region: PRK03636 649639005469 UPF0302 domain; Region: UPF0302; pfam08864 649639005470 A short protein domain of unknown function; Region: IDEAL; smart00914 649639005471 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 649639005472 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 649639005473 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 649639005474 iron-sulfur cluster [ion binding]; other site 649639005475 [2Fe-2S] cluster binding site [ion binding]; other site 649639005476 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 649639005477 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 649639005478 interchain domain interface [polypeptide binding]; other site 649639005479 intrachain domain interface; other site 649639005480 heme bH binding site [chemical binding]; other site 649639005481 Qi binding site; other site 649639005482 heme bL binding site [chemical binding]; other site 649639005483 Qo binding site; other site 649639005484 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 649639005485 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 649639005486 interchain domain interface [polypeptide binding]; other site 649639005487 intrachain domain interface; other site 649639005488 Qo binding site; other site 649639005489 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 649639005490 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 649639005491 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 649639005492 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 649639005493 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 649639005494 Uncharacterized conserved protein [Function unknown]; Region: COG1284 649639005495 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 649639005496 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 649639005497 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 649639005498 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 649639005499 homodimer interface [polypeptide binding]; other site 649639005500 metal binding site [ion binding]; metal-binding site 649639005501 dihydrodipicolinate reductase; Provisional; Region: PRK00048 649639005502 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 649639005503 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 649639005504 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 649639005505 active site 649639005506 dimer interfaces [polypeptide binding]; other site 649639005507 catalytic residues [active] 649639005508 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 649639005509 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 649639005510 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 649639005511 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 649639005512 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 649639005513 active site 649639005514 NTP binding site [chemical binding]; other site 649639005515 metal binding triad [ion binding]; metal-binding site 649639005516 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 649639005517 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 649639005518 Biotin operon repressor [Transcription]; Region: BirA; COG1654 649639005519 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 649639005520 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 649639005521 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 649639005522 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 649639005523 oligomerization interface [polypeptide binding]; other site 649639005524 active site 649639005525 metal binding site [ion binding]; metal-binding site 649639005526 pantoate--beta-alanine ligase; Region: panC; TIGR00018 649639005527 Pantoate-beta-alanine ligase; Region: PanC; cd00560 649639005528 active site 649639005529 ATP-binding site [chemical binding]; other site 649639005530 pantoate-binding site; other site 649639005531 HXXH motif; other site 649639005532 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 649639005533 tetramerization interface [polypeptide binding]; other site 649639005534 active site 649639005535 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 649639005536 TPR motif; other site 649639005537 binding surface 649639005538 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649639005539 binding surface 649639005540 TPR motif; other site 649639005541 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649639005542 binding surface 649639005543 TPR motif; other site 649639005544 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 649639005545 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 649639005546 active site 649639005547 catalytic site [active] 649639005548 substrate binding site [chemical binding]; other site 649639005549 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 649639005550 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 649639005551 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 649639005552 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 649639005553 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 649639005554 active site 649639005555 putative substrate binding pocket [chemical binding]; other site 649639005556 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 649639005557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 649639005558 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 649639005559 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 649639005560 putative dimer interface [polypeptide binding]; other site 649639005561 putative anticodon binding site; other site 649639005562 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 649639005563 homodimer interface [polypeptide binding]; other site 649639005564 motif 1; other site 649639005565 motif 2; other site 649639005566 active site 649639005567 motif 3; other site 649639005568 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 649639005569 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 649639005570 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 649639005571 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 649639005572 minor groove reading motif; other site 649639005573 helix-hairpin-helix signature motif; other site 649639005574 substrate binding pocket [chemical binding]; other site 649639005575 active site 649639005576 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 649639005577 Transglycosylase; Region: Transgly; pfam00912 649639005578 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 649639005579 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 649639005580 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 649639005581 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 649639005582 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 649639005583 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 649639005584 FOG: CBS domain [General function prediction only]; Region: COG0517 649639005585 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 649639005586 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 649639005587 Isochorismatase family; Region: Isochorismatase; pfam00857 649639005588 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 649639005589 catalytic triad [active] 649639005590 conserved cis-peptide bond; other site 649639005591 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 649639005592 catalytic residues [active] 649639005593 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 649639005594 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 649639005595 catalytic residues [active] 649639005596 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 649639005597 Virulence factor; Region: Virulence_fact; pfam13769 649639005598 HEAT repeats; Region: HEAT_2; pfam13646 649639005599 HEAT repeats; Region: HEAT_2; pfam13646 649639005600 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 649639005601 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 649639005602 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 649639005603 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 649639005604 Uncharacterized conserved protein [Function unknown]; Region: COG3402 649639005605 Predicted membrane protein [Function unknown]; Region: COG3428 649639005606 Bacterial PH domain; Region: DUF304; pfam03703 649639005607 Bacterial PH domain; Region: DUF304; pfam03703 649639005608 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 649639005609 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 649639005610 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 649639005611 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 649639005612 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 649639005613 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 649639005614 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 649639005615 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 649639005616 Substrate-binding site [chemical binding]; other site 649639005617 Substrate specificity [chemical binding]; other site 649639005618 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 649639005619 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 649639005620 Substrate-binding site [chemical binding]; other site 649639005621 Substrate specificity [chemical binding]; other site 649639005622 EDD domain protein, DegV family; Region: DegV; TIGR00762 649639005623 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 649639005624 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 649639005625 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 649639005626 active site 649639005627 nucleophile elbow; other site 649639005628 drug efflux system protein MdtG; Provisional; Region: PRK09874 649639005629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639005630 putative substrate translocation pore; other site 649639005631 Protein of unknown function (DUF420); Region: DUF420; pfam04238 649639005632 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 649639005633 active site 649639005634 catalytic triad [active] 649639005635 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 649639005636 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 649639005637 Zn binding site [ion binding]; other site 649639005638 toxin interface [polypeptide binding]; other site 649639005639 acetyl-CoA synthetase; Provisional; Region: PRK04319 649639005640 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 649639005641 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 649639005642 active site 649639005643 acyl-activating enzyme (AAE) consensus motif; other site 649639005644 putative CoA binding site [chemical binding]; other site 649639005645 AMP binding site [chemical binding]; other site 649639005646 fumarate hydratase; Reviewed; Region: fumC; PRK00485 649639005647 Class II fumarases; Region: Fumarase_classII; cd01362 649639005648 active site 649639005649 tetramer interface [polypeptide binding]; other site 649639005650 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 649639005651 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 649639005652 active site 649639005653 dimer interface [polypeptide binding]; other site 649639005654 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 649639005655 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 649639005656 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 649639005657 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 649639005658 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 649639005659 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 649639005660 substrate binding pocket [chemical binding]; other site 649639005661 aminotransferase A; Validated; Region: PRK07683 649639005662 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 649639005663 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639005664 homodimer interface [polypeptide binding]; other site 649639005665 catalytic residue [active] 649639005666 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 649639005667 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 649639005668 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 649639005669 TPP-binding site [chemical binding]; other site 649639005670 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 649639005671 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 649639005672 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 649639005673 E3 interaction surface; other site 649639005674 lipoyl attachment site [posttranslational modification]; other site 649639005675 e3 binding domain; Region: E3_binding; pfam02817 649639005676 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 649639005677 HD domain; Region: HD_4; pfam13328 649639005678 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 649639005679 Uncharacterized conserved protein [Function unknown]; Region: COG0398 649639005680 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 649639005681 Predicted membrane protein [Function unknown]; Region: COG4129 649639005682 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 649639005683 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 649639005684 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 649639005685 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 649639005686 Part of AAA domain; Region: AAA_19; pfam13245 649639005687 Family description; Region: UvrD_C_2; pfam13538 649639005688 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 649639005689 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 649639005690 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 649639005691 active site 649639005692 metal binding site [ion binding]; metal-binding site 649639005693 DNA binding site [nucleotide binding] 649639005694 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 649639005695 exonuclease SbcC; Region: sbcc; TIGR00618 649639005696 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 649639005697 Walker A/P-loop; other site 649639005698 ATP binding site [chemical binding]; other site 649639005699 Q-loop/lid; other site 649639005700 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 649639005701 ABC transporter signature motif; other site 649639005702 Walker B; other site 649639005703 D-loop; other site 649639005704 H-loop/switch region; other site 649639005705 Protein of unknown function (DUF952); Region: DUF952; pfam06108 649639005706 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 649639005707 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649639005708 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649639005709 ABC transporter; Region: ABC_tran_2; pfam12848 649639005710 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649639005711 oligoendopeptidase F; Region: pepF; TIGR00181 649639005712 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 649639005713 Zn binding site [ion binding]; other site 649639005714 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 649639005715 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 649639005716 putative active site [active] 649639005717 putative NTP binding site [chemical binding]; other site 649639005718 putative nucleic acid binding site [nucleotide binding]; other site 649639005719 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 649639005720 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 649639005721 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 649639005722 Walker A/P-loop; other site 649639005723 ATP binding site [chemical binding]; other site 649639005724 Q-loop/lid; other site 649639005725 ABC transporter signature motif; other site 649639005726 Walker B; other site 649639005727 D-loop; other site 649639005728 H-loop/switch region; other site 649639005729 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 649639005730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639005731 dimer interface [polypeptide binding]; other site 649639005732 conserved gate region; other site 649639005733 putative PBP binding loops; other site 649639005734 ABC-ATPase subunit interface; other site 649639005735 NMT1-like family; Region: NMT1_2; pfam13379 649639005736 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 649639005737 substrate binding pocket [chemical binding]; other site 649639005738 membrane-bound complex binding site; other site 649639005739 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 649639005740 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 649639005741 putative catalytic cysteine [active] 649639005742 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 649639005743 putative active site [active] 649639005744 metal binding site [ion binding]; metal-binding site 649639005745 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 649639005746 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649639005747 FeS/SAM binding site; other site 649639005748 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 649639005749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639005750 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 649639005751 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 649639005752 classical (c) SDRs; Region: SDR_c; cd05233 649639005753 NAD(P) binding site [chemical binding]; other site 649639005754 active site 649639005755 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 649639005756 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639005757 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 649639005758 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 649639005759 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 649639005760 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 649639005761 putative active site [active] 649639005762 catalytic site [active] 649639005763 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 649639005764 putative active site [active] 649639005765 catalytic site [active] 649639005766 sulfite oxidase; Provisional; Region: PLN00177 649639005767 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 649639005768 Moco binding site; other site 649639005769 metal coordination site [ion binding]; other site 649639005770 dimerization interface [polypeptide binding]; other site 649639005771 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 649639005772 Putative ammonia monooxygenase; Region: AmoA; pfam05145 649639005773 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 649639005774 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 649639005775 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649639005776 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 649639005777 PGAP1-like protein; Region: PGAP1; pfam07819 649639005778 TAP-like protein; Region: Abhydrolase_4; pfam08386 649639005779 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 649639005780 Zn binding site [ion binding]; other site 649639005781 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 649639005782 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649639005783 Zn binding site [ion binding]; other site 649639005784 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 649639005785 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 649639005786 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 649639005787 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 649639005788 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 649639005789 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 649639005790 inhibitor-cofactor binding pocket; inhibition site 649639005791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639005792 catalytic residue [active] 649639005793 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649639005794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639005795 Coenzyme A binding pocket [chemical binding]; other site 649639005796 Predicted permeases [General function prediction only]; Region: COG0679 649639005797 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 649639005798 MoxR-like ATPases [General function prediction only]; Region: COG0714 649639005799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639005800 Walker A motif; other site 649639005801 ATP binding site [chemical binding]; other site 649639005802 Walker B motif; other site 649639005803 arginine finger; other site 649639005804 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 649639005805 Protein of unknown function DUF58; Region: DUF58; pfam01882 649639005806 Beta-lactamase; Region: Beta-lactamase; pfam00144 649639005807 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649639005808 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 649639005809 Acyltransferase family; Region: Acyl_transf_3; pfam01757 649639005810 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649639005811 dimerization interface [polypeptide binding]; other site 649639005812 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639005813 dimer interface [polypeptide binding]; other site 649639005814 phosphorylation site [posttranslational modification] 649639005815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639005816 ATP binding site [chemical binding]; other site 649639005817 Mg2+ binding site [ion binding]; other site 649639005818 G-X-G motif; other site 649639005819 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649639005820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639005821 active site 649639005822 phosphorylation site [posttranslational modification] 649639005823 intermolecular recognition site; other site 649639005824 dimerization interface [polypeptide binding]; other site 649639005825 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649639005826 DNA binding site [nucleotide binding] 649639005827 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 649639005828 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 649639005829 putative catalytic cysteine [active] 649639005830 gamma-glutamyl kinase; Provisional; Region: PRK05429 649639005831 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 649639005832 nucleotide binding site [chemical binding]; other site 649639005833 homotetrameric interface [polypeptide binding]; other site 649639005834 putative phosphate binding site [ion binding]; other site 649639005835 putative allosteric binding site; other site 649639005836 PUA domain; Region: PUA; pfam01472 649639005837 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 649639005838 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649639005839 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 649639005840 active site 649639005841 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 649639005842 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 649639005843 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 649639005844 homodimer interface [polypeptide binding]; other site 649639005845 substrate-cofactor binding pocket; other site 649639005846 catalytic residue [active] 649639005847 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 649639005848 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 649639005849 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 649639005850 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 649639005851 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 649639005852 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 649639005853 metal binding triad; other site 649639005854 hypothetical protein; Provisional; Region: PRK07740 649639005855 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 649639005856 active site 649639005857 catalytic site [active] 649639005858 substrate binding site [chemical binding]; other site 649639005859 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 649639005860 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649639005861 DNA binding residues [nucleotide binding] 649639005862 putative dimer interface [polypeptide binding]; other site 649639005863 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 649639005864 EamA-like transporter family; Region: EamA; pfam00892 649639005865 EamA-like transporter family; Region: EamA; pfam00892 649639005866 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 649639005867 DNA topoisomerase III; Provisional; Region: PRK07726 649639005868 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 649639005869 active site 649639005870 putative interdomain interaction site [polypeptide binding]; other site 649639005871 putative metal-binding site [ion binding]; other site 649639005872 putative nucleotide binding site [chemical binding]; other site 649639005873 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 649639005874 domain I; other site 649639005875 DNA binding groove [nucleotide binding] 649639005876 phosphate binding site [ion binding]; other site 649639005877 domain II; other site 649639005878 domain III; other site 649639005879 nucleotide binding site [chemical binding]; other site 649639005880 catalytic site [active] 649639005881 domain IV; other site 649639005882 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 649639005883 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 649639005884 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 649639005885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639005886 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649639005887 putative substrate translocation pore; other site 649639005888 Uncharacterized conserved protein [Function unknown]; Region: COG1284 649639005889 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 649639005890 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 649639005891 LysE type translocator; Region: LysE; pfam01810 649639005892 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 649639005893 Spore germination protein; Region: Spore_permease; cl17796 649639005894 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 649639005895 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 649639005896 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 649639005897 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 649639005898 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 649639005899 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 649639005900 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 649639005901 catalytic loop [active] 649639005902 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 649639005903 iron binding site [ion binding]; other site 649639005904 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 649639005905 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649639005906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649639005907 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 649639005908 Dynamin family; Region: Dynamin_N; pfam00350 649639005909 G1 box; other site 649639005910 GTP/Mg2+ binding site [chemical binding]; other site 649639005911 G2 box; other site 649639005912 Switch I region; other site 649639005913 G3 box; other site 649639005914 Switch II region; other site 649639005915 G4 box; other site 649639005916 G5 box; other site 649639005917 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 649639005918 Dynamin family; Region: Dynamin_N; pfam00350 649639005919 G1 box; other site 649639005920 GTP/Mg2+ binding site [chemical binding]; other site 649639005921 G2 box; other site 649639005922 Switch I region; other site 649639005923 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 649639005924 G3 box; other site 649639005925 Switch II region; other site 649639005926 GTP/Mg2+ binding site [chemical binding]; other site 649639005927 G4 box; other site 649639005928 G5 box; other site 649639005929 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 649639005930 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 649639005931 active site 649639005932 catalytic site [active] 649639005933 substrate binding site [chemical binding]; other site 649639005934 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 649639005935 dimer interface [polypeptide binding]; other site 649639005936 FMN binding site [chemical binding]; other site 649639005937 Uncharacterized conserved protein [Function unknown]; Region: COG1284 649639005938 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 649639005939 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 649639005940 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 649639005941 threonine dehydratase; Validated; Region: PRK08639 649639005942 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 649639005943 tetramer interface [polypeptide binding]; other site 649639005944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639005945 catalytic residue [active] 649639005946 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 649639005947 putative Ile/Val binding site [chemical binding]; other site 649639005948 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649639005949 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649639005950 dimer interface [polypeptide binding]; other site 649639005951 putative CheW interface [polypeptide binding]; other site 649639005952 DEAD-like helicases superfamily; Region: DEXDc; smart00487 649639005953 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 649639005954 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649639005955 nucleotide binding region [chemical binding]; other site 649639005956 ATP-binding site [chemical binding]; other site 649639005957 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 649639005958 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 649639005959 dimerization interface [polypeptide binding]; other site 649639005960 ligand binding site [chemical binding]; other site 649639005961 NADP binding site [chemical binding]; other site 649639005962 catalytic site [active] 649639005963 MOSC domain; Region: MOSC; pfam03473 649639005964 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 649639005965 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 649639005966 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 649639005967 Spore germination protein; Region: Spore_permease; cl17796 649639005968 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 649639005969 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 649639005970 S1 domain; Region: S1_2; pfam13509 649639005971 beta-phosphoglucomutase; Region: bPGM; TIGR01990 649639005972 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639005973 motif II; other site 649639005974 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 649639005975 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 649639005976 Peptidase family M23; Region: Peptidase_M23; pfam01551 649639005977 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 649639005978 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 649639005979 Acyltransferase family; Region: Acyl_transf_3; pfam01757 649639005980 short chain dehydrogenase; Provisional; Region: PRK06914 649639005981 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 649639005982 NADP binding site [chemical binding]; other site 649639005983 active site 649639005984 steroid binding site; other site 649639005985 FIST N domain; Region: FIST; pfam08495 649639005986 FIST C domain; Region: FIST_C; pfam10442 649639005987 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 649639005988 GAF domain; Region: GAF_3; pfam13492 649639005989 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649639005990 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649639005991 metal binding site [ion binding]; metal-binding site 649639005992 active site 649639005993 I-site; other site 649639005994 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 649639005995 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 649639005996 NADH(P)-binding; Region: NAD_binding_10; pfam13460 649639005997 NAD(P) binding site [chemical binding]; other site 649639005998 putative active site [active] 649639005999 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 649639006000 Protein of unknown function (DUF523); Region: DUF523; pfam04463 649639006001 Uncharacterized conserved protein [Function unknown]; Region: COG3272 649639006002 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 649639006003 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 649639006004 hydrophobic ligand binding site; other site 649639006005 MMPL family; Region: MMPL; pfam03176 649639006006 MMPL family; Region: MMPL; pfam03176 649639006007 metal-dependent hydrolase; Provisional; Region: PRK13291 649639006008 DinB superfamily; Region: DinB_2; pfam12867 649639006009 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 649639006010 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 649639006011 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 649639006012 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 649639006013 HNH endonuclease; Region: HNH_3; pfam13392 649639006014 PemK-like protein; Region: PemK; pfam02452 649639006015 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 649639006016 Phage terminase, small subunit; Region: Terminase_4; pfam05119 649639006017 Phage Terminase; Region: Terminase_1; pfam03354 649639006018 Phage portal protein; Region: Phage_portal; pfam04860 649639006019 Phage-related protein [Function unknown]; Region: COG4695; cl01923 649639006020 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 649639006021 oligomer interface [polypeptide binding]; other site 649639006022 Clp protease; Region: CLP_protease; pfam00574 649639006023 active site residues [active] 649639006024 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 649639006025 Phage capsid family; Region: Phage_capsid; pfam05065 649639006026 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 649639006027 oligomerization interface [polypeptide binding]; other site 649639006028 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 649639006029 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 649639006030 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 649639006031 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 649639006032 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 649639006033 Phage-related protein [Function unknown]; Region: COG4722 649639006034 Phage tail protein; Region: Sipho_tail; pfam05709 649639006035 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649639006036 non-specific DNA binding site [nucleotide binding]; other site 649639006037 salt bridge; other site 649639006038 sequence-specific DNA binding site [nucleotide binding]; other site 649639006039 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 649639006040 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 649639006041 active site 649639006042 DNA binding site [nucleotide binding] 649639006043 Int/Topo IB signature motif; other site 649639006044 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 649639006045 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 649639006046 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 649639006047 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 649639006048 active site 649639006049 metal binding site [ion binding]; metal-binding site 649639006050 Sporulation related domain; Region: SPOR; pfam05036 649639006051 YolD-like protein; Region: YolD; pfam08863 649639006052 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649639006053 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649639006054 non-specific DNA binding site [nucleotide binding]; other site 649639006055 salt bridge; other site 649639006056 sequence-specific DNA binding site [nucleotide binding]; other site 649639006057 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 649639006058 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 649639006059 sequence-specific DNA binding site [nucleotide binding]; other site 649639006060 salt bridge; other site 649639006061 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 649639006062 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 649639006063 active site 649639006064 DNA binding site [nucleotide binding] 649639006065 Int/Topo IB signature motif; other site 649639006066 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 649639006067 active site 649639006068 catalytic site [active] 649639006069 substrate binding site [chemical binding]; other site 649639006070 selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475 649639006071 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 649639006072 G1 box; other site 649639006073 putative GEF interaction site [polypeptide binding]; other site 649639006074 GTP/Mg2+ binding site [chemical binding]; other site 649639006075 Switch I region; other site 649639006076 G2 box; other site 649639006077 G3 box; other site 649639006078 Switch II region; other site 649639006079 G4 box; other site 649639006080 G5 box; other site 649639006081 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 649639006082 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 649639006083 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 649639006084 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649639006085 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649639006086 metal binding site [ion binding]; metal-binding site 649639006087 active site 649639006088 I-site; other site 649639006089 selenophosphate synthetase; Provisional; Region: PRK00943 649639006090 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 649639006091 dimerization interface [polypeptide binding]; other site 649639006092 putative ATP binding site [chemical binding]; other site 649639006093 Rdx family; Region: Rdx; pfam10262 649639006094 selenocysteine synthase; Provisional; Region: PRK04311 649639006095 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 649639006096 Small acid-soluble spore protein P family; Region: SspP; cl12105 649639006097 aconitate hydratase; Validated; Region: PRK09277 649639006098 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 649639006099 substrate binding site [chemical binding]; other site 649639006100 ligand binding site [chemical binding]; other site 649639006101 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 649639006102 substrate binding site [chemical binding]; other site 649639006103 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 649639006104 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 649639006105 Predicted membrane protein [Function unknown]; Region: COG2323 649639006106 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 649639006107 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 649639006108 VanZ like family; Region: VanZ; pfam04892 649639006109 Uncharacterized conserved protein [Function unknown]; Region: COG0398 649639006110 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 649639006111 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 649639006112 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639006113 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639006114 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 649639006115 active site 649639006116 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 649639006117 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639006118 Coenzyme A binding pocket [chemical binding]; other site 649639006119 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 649639006120 EamA-like transporter family; Region: EamA; pfam00892 649639006121 EamA-like transporter family; Region: EamA; pfam00892 649639006122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639006123 Walker A motif; other site 649639006124 ATP binding site [chemical binding]; other site 649639006125 Walker B motif; other site 649639006126 arginine finger; other site 649639006127 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639006128 AAA domain; Region: AAA_22; pfam13401 649639006129 Walker A motif; other site 649639006130 ATP binding site [chemical binding]; other site 649639006131 Walker B motif; other site 649639006132 arginine finger; other site 649639006133 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 649639006134 active site 649639006135 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 649639006136 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 649639006137 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 649639006138 homodimer interface [polypeptide binding]; other site 649639006139 NAD binding pocket [chemical binding]; other site 649639006140 ATP binding pocket [chemical binding]; other site 649639006141 Mg binding site [ion binding]; other site 649639006142 active-site loop [active] 649639006143 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 649639006144 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 649639006145 active site 649639006146 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 649639006147 hypothetical protein; Provisional; Region: PRK06851 649639006148 NTPase; Region: NTPase_1; cl17478 649639006149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639006150 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 649639006151 putative substrate translocation pore; other site 649639006152 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 649639006153 Uncharacterized conserved protein [Function unknown]; Region: COG0398 649639006154 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 649639006155 YwpF-like protein; Region: YwpF; pfam14183 649639006156 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649639006157 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639006158 Coenzyme A binding pocket [chemical binding]; other site 649639006159 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649639006160 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 649639006161 active site 649639006162 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 649639006163 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 649639006164 Hemerythrin-like domain; Region: Hr-like; cd12108 649639006165 Fe binding site [ion binding]; other site 649639006166 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 649639006167 active site 649639006168 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 649639006169 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 649639006170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639006171 active site 649639006172 phosphorylation site [posttranslational modification] 649639006173 intermolecular recognition site; other site 649639006174 dimerization interface [polypeptide binding]; other site 649639006175 YhfH-like protein; Region: YhfH; pfam14149 649639006176 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 649639006177 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674 649639006178 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 649639006179 dimer interface [polypeptide binding]; other site 649639006180 PYR/PP interface [polypeptide binding]; other site 649639006181 TPP binding site [chemical binding]; other site 649639006182 substrate binding site [chemical binding]; other site 649639006183 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 649639006184 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 649639006185 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 649639006186 TPP-binding site [chemical binding]; other site 649639006187 putative dimer interface [polypeptide binding]; other site 649639006188 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 649639006189 pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional; Region: PRK14028 649639006190 4Fe-4S binding domain; Region: Fer4; pfam00037 649639006191 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 649639006192 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 649639006193 Zn2+ binding site [ion binding]; other site 649639006194 Mg2+ binding site [ion binding]; other site 649639006195 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 649639006196 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649639006197 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649639006198 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 649639006199 NlpC/P60 family; Region: NLPC_P60; pfam00877 649639006200 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 649639006201 proposed catalytic triad [active] 649639006202 conserved cys residue [active] 649639006203 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 649639006204 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649639006205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639006206 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649639006207 putative substrate translocation pore; other site 649639006208 B12 binding domain; Region: B12-binding_2; pfam02607 649639006209 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 649639006210 B12 binding site [chemical binding]; other site 649639006211 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 649639006212 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 649639006213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639006214 putative substrate translocation pore; other site 649639006215 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 649639006216 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 649639006217 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 649639006218 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 649639006219 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639006220 NlpC/P60 family; Region: NLPC_P60; pfam00877 649639006221 CHASE3 domain; Region: CHASE3; cl05000 649639006222 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 649639006223 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 649639006224 GAF domain; Region: GAF_2; pfam13185 649639006225 GAF domain; Region: GAF; pfam01590 649639006226 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639006227 dimer interface [polypeptide binding]; other site 649639006228 phosphorylation site [posttranslational modification] 649639006229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639006230 ATP binding site [chemical binding]; other site 649639006231 Mg2+ binding site [ion binding]; other site 649639006232 G-X-G motif; other site 649639006233 Response regulator receiver domain; Region: Response_reg; pfam00072 649639006234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639006235 active site 649639006236 phosphorylation site [posttranslational modification] 649639006237 intermolecular recognition site; other site 649639006238 dimerization interface [polypeptide binding]; other site 649639006239 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 649639006240 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 649639006241 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 649639006242 Response regulator receiver domain; Region: Response_reg; pfam00072 649639006243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639006244 active site 649639006245 phosphorylation site [posttranslational modification] 649639006246 intermolecular recognition site; other site 649639006247 dimerization interface [polypeptide binding]; other site 649639006248 PAS domain S-box; Region: sensory_box; TIGR00229 649639006249 PAS domain; Region: PAS_8; pfam13188 649639006250 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649639006251 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639006252 dimer interface [polypeptide binding]; other site 649639006253 phosphorylation site [posttranslational modification] 649639006254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639006255 ATP binding site [chemical binding]; other site 649639006256 Mg2+ binding site [ion binding]; other site 649639006257 G-X-G motif; other site 649639006258 6-phosphofructokinase; Provisional; Region: PRK03202 649639006259 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 649639006260 active site 649639006261 ADP/pyrophosphate binding site [chemical binding]; other site 649639006262 dimerization interface [polypeptide binding]; other site 649639006263 allosteric effector site; other site 649639006264 fructose-1,6-bisphosphate binding site; other site 649639006265 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 649639006266 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 649639006267 metal binding site [ion binding]; metal-binding site 649639006268 Transposase; Region: DEDD_Tnp_IS110; pfam01548 649639006269 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 649639006270 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 649639006271 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 649639006272 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 649639006273 hypothetical protein; Provisional; Region: PRK08201 649639006274 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 649639006275 metal binding site [ion binding]; metal-binding site 649639006276 putative dimer interface [polypeptide binding]; other site 649639006277 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 649639006278 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649639006279 ATP binding site [chemical binding]; other site 649639006280 putative Mg++ binding site [ion binding]; other site 649639006281 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649639006282 nucleotide binding region [chemical binding]; other site 649639006283 ATP-binding site [chemical binding]; other site 649639006284 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 649639006285 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 649639006286 RNase_H superfamily; Region: RNase_H_2; pfam13482 649639006287 active site 649639006288 catalytic site [active] 649639006289 substrate binding site [chemical binding]; other site 649639006290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649639006291 TPR motif; other site 649639006292 TPR repeat; Region: TPR_11; pfam13414 649639006293 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 649639006294 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 649639006295 catalytic loop [active] 649639006296 iron binding site [ion binding]; other site 649639006297 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 649639006298 hypothetical protein; Provisional; Region: PRK13660 649639006299 cell division protein GpsB; Provisional; Region: PRK14127 649639006300 DivIVA domain; Region: DivI1A_domain; TIGR03544 649639006301 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 649639006302 RNA/DNA hybrid binding site [nucleotide binding]; other site 649639006303 active site 649639006304 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 649639006305 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 649639006306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 649639006307 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 649639006308 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 649639006309 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649639006310 FeS/SAM binding site; other site 649639006311 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 649639006312 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 649639006313 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 649639006314 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 649639006315 active site 649639006316 Zn binding site [ion binding]; other site 649639006317 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649639006318 Ligand Binding Site [chemical binding]; other site 649639006319 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 649639006320 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 649639006321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639006322 ATP binding site [chemical binding]; other site 649639006323 Mg2+ binding site [ion binding]; other site 649639006324 G-X-G motif; other site 649639006325 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 649639006326 anchoring element; other site 649639006327 dimer interface [polypeptide binding]; other site 649639006328 ATP binding site [chemical binding]; other site 649639006329 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 649639006330 active site 649639006331 putative metal-binding site [ion binding]; other site 649639006332 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 649639006333 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 649639006334 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 649639006335 CAP-like domain; other site 649639006336 active site 649639006337 primary dimer interface [polypeptide binding]; other site 649639006338 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 649639006339 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 649639006340 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 649639006341 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 649639006342 Spore germination protein; Region: Spore_permease; cl17796 649639006343 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 649639006344 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 649639006345 PilZ domain; Region: PilZ; pfam07238 649639006346 PAS domain S-box; Region: sensory_box; TIGR00229 649639006347 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649639006348 putative active site [active] 649639006349 heme pocket [chemical binding]; other site 649639006350 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649639006351 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649639006352 metal binding site [ion binding]; metal-binding site 649639006353 active site 649639006354 I-site; other site 649639006355 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649639006356 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 649639006357 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649639006358 putative active site [active] 649639006359 heme pocket [chemical binding]; other site 649639006360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639006361 dimer interface [polypeptide binding]; other site 649639006362 phosphorylation site [posttranslational modification] 649639006363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639006364 ATP binding site [chemical binding]; other site 649639006365 Mg2+ binding site [ion binding]; other site 649639006366 G-X-G motif; other site 649639006367 GAF domain; Region: GAF; pfam01590 649639006368 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649639006369 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649639006370 DNA binding residues [nucleotide binding] 649639006371 dimerization interface [polypeptide binding]; other site 649639006372 KaiC; Region: KaiC; pfam06745 649639006373 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 649639006374 Walker A motif; other site 649639006375 ATP binding site [chemical binding]; other site 649639006376 Walker B motif; other site 649639006377 Transcriptional regulator [Transcription]; Region: LysR; COG0583 649639006378 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649639006379 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 649639006380 putative dimerization interface [polypeptide binding]; other site 649639006381 glutamate dehydrogenase; Provisional; Region: PRK09414 649639006382 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 649639006383 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 649639006384 NAD(P) binding site [chemical binding]; other site 649639006385 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 649639006386 dihydrodipicolinate synthase; Region: dapA; TIGR00674 649639006387 dimer interface [polypeptide binding]; other site 649639006388 active site 649639006389 catalytic residue [active] 649639006390 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 649639006391 active site 649639006392 catalytic site [active] 649639006393 substrate binding site [chemical binding]; other site 649639006394 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 649639006395 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649639006396 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 649639006397 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 649639006398 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 649639006399 active site 649639006400 NAD binding site [chemical binding]; other site 649639006401 metal binding site [ion binding]; metal-binding site 649639006402 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 649639006403 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 649639006404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639006405 putative substrate translocation pore; other site 649639006406 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 649639006407 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 649639006408 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649639006409 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 649639006410 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639006411 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 649639006412 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639006413 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639006414 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 649639006415 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639006416 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 649639006417 Kinase associated protein B; Region: KapB; pfam08810 649639006418 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 649639006419 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639006420 motif II; other site 649639006421 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649639006422 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 649639006423 Walker A/P-loop; other site 649639006424 ATP binding site [chemical binding]; other site 649639006425 Q-loop/lid; other site 649639006426 ABC transporter signature motif; other site 649639006427 Walker B; other site 649639006428 D-loop; other site 649639006429 H-loop/switch region; other site 649639006430 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649639006431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639006432 putative substrate translocation pore; other site 649639006433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639006434 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 649639006435 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 649639006436 Nitrogen regulatory protein P-II; Region: P-II; smart00938 649639006437 Predicted transcriptional regulators [Transcription]; Region: COG1725 649639006438 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649639006439 DNA-binding site [nucleotide binding]; DNA binding site 649639006440 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649639006441 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 649639006442 Walker A/P-loop; other site 649639006443 ATP binding site [chemical binding]; other site 649639006444 Q-loop/lid; other site 649639006445 ABC transporter signature motif; other site 649639006446 Walker B; other site 649639006447 D-loop; other site 649639006448 H-loop/switch region; other site 649639006449 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 649639006450 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639006451 Walker A/P-loop; other site 649639006452 ATP binding site [chemical binding]; other site 649639006453 Q-loop/lid; other site 649639006454 ABC transporter signature motif; other site 649639006455 Walker B; other site 649639006456 D-loop; other site 649639006457 H-loop/switch region; other site 649639006458 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 649639006459 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 649639006460 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649639006461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639006462 active site 649639006463 phosphorylation site [posttranslational modification] 649639006464 intermolecular recognition site; other site 649639006465 dimerization interface [polypeptide binding]; other site 649639006466 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649639006467 DNA binding residues [nucleotide binding] 649639006468 dimerization interface [polypeptide binding]; other site 649639006469 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649639006470 Optic atrophy 3 protein (OPA3); Region: OPA3; pfam07047 649639006471 Histidine kinase; Region: HisKA_3; pfam07730 649639006472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639006473 ATP binding site [chemical binding]; other site 649639006474 Mg2+ binding site [ion binding]; other site 649639006475 G-X-G motif; other site 649639006476 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 649639006477 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 649639006478 putative di-iron ligands [ion binding]; other site 649639006479 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 649639006480 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 649639006481 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649639006482 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649639006483 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 649639006484 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649639006485 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649639006486 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 649639006487 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 649639006488 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 649639006489 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649639006490 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 649639006491 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 649639006492 ATP binding site [chemical binding]; other site 649639006493 Mg++ binding site [ion binding]; other site 649639006494 motif III; other site 649639006495 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649639006496 nucleotide binding region [chemical binding]; other site 649639006497 ATP-binding site [chemical binding]; other site 649639006498 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 649639006499 EDD domain protein, DegV family; Region: DegV; TIGR00762 649639006500 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 649639006501 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649639006502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639006503 LrgB-like family; Region: LrgB; pfam04172 649639006504 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 649639006505 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 649639006506 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 649639006507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639006508 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649639006509 putative substrate translocation pore; other site 649639006510 Protein of unknown function, DUF624; Region: DUF624; cl02369 649639006511 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649639006512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639006513 dimer interface [polypeptide binding]; other site 649639006514 conserved gate region; other site 649639006515 putative PBP binding loops; other site 649639006516 ABC-ATPase subunit interface; other site 649639006517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 649639006518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639006519 dimer interface [polypeptide binding]; other site 649639006520 putative PBP binding loops; other site 649639006521 ABC-ATPase subunit interface; other site 649639006522 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649639006523 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 649639006524 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 649639006525 Double zinc ribbon; Region: DZR; pfam12773 649639006526 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 649639006527 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 649639006528 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 649639006529 active sites [active] 649639006530 tetramer interface [polypeptide binding]; other site 649639006531 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 649639006532 Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949 649639006533 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 649639006534 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 649639006535 ATP-grasp domain; Region: ATP-grasp_4; cl17255 649639006536 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 649639006537 metal binding site [ion binding]; metal-binding site 649639006538 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 649639006539 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 649639006540 hypothetical protein; Provisional; Region: PRK12378 649639006541 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 649639006542 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 649639006543 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 649639006544 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 649639006545 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 649639006546 active site 649639006547 TIGR01177 family protein; Region: TIGR01177 649639006548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639006549 S-adenosylmethionine binding site [chemical binding]; other site 649639006550 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 649639006551 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 649639006552 DNA-binding site [nucleotide binding]; DNA binding site 649639006553 RNA-binding motif; other site 649639006554 Predicted transcriptional regulators [Transcription]; Region: COG1695 649639006555 Transcriptional regulator PadR-like family; Region: PadR; cl17335 649639006556 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 649639006557 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 649639006558 active site 649639006559 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 649639006560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639006561 S-adenosylmethionine binding site [chemical binding]; other site 649639006562 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 649639006563 classical (c) SDRs; Region: SDR_c; cd05233 649639006564 NAD(P) binding site [chemical binding]; other site 649639006565 active site 649639006566 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 649639006567 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 649639006568 UbiA prenyltransferase family; Region: UbiA; pfam01040 649639006569 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 649639006570 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 649639006571 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 649639006572 D-pathway; other site 649639006573 Low-spin heme binding site [chemical binding]; other site 649639006574 Putative water exit pathway; other site 649639006575 Binuclear center (active site) [active] 649639006576 K-pathway; other site 649639006577 Putative proton exit pathway; other site 649639006578 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 649639006579 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 649639006580 Cu(I) binding site [ion binding]; other site 649639006581 YkyB-like protein; Region: YkyB; pfam14177 649639006582 Predicted amidohydrolase [General function prediction only]; Region: COG0388 649639006583 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 649639006584 active site 649639006585 catalytic triad [active] 649639006586 dimer interface [polypeptide binding]; other site 649639006587 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 649639006588 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 649639006589 Walker A/P-loop; other site 649639006590 ATP binding site [chemical binding]; other site 649639006591 Q-loop/lid; other site 649639006592 ABC transporter signature motif; other site 649639006593 Walker B; other site 649639006594 D-loop; other site 649639006595 H-loop/switch region; other site 649639006596 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 649639006597 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649639006598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639006599 putative substrate translocation pore; other site 649639006600 Small acid-soluble spore protein H family; Region: SspH; cl06949 649639006601 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 649639006602 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 649639006603 conserved cys residue [active] 649639006604 Glycoside hydrolase family 94 N-terminal-like domain of uncharacterized function; Region: GH94N_like_3; cd11750 649639006605 Protein of unknown function, DUF608; Region: DUF608; pfam04685 649639006606 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 649639006607 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649639006608 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 649639006609 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 649639006610 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639006611 Coenzyme A binding pocket [chemical binding]; other site 649639006612 YfhD-like protein; Region: YfhD; pfam14151 649639006613 PGDYG protein; Region: PGDYG; pfam14083 649639006614 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 649639006615 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 649639006616 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 649639006617 NodB motif; other site 649639006618 active site 649639006619 catalytic site [active] 649639006620 metal binding site [ion binding]; metal-binding site 649639006621 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 649639006622 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649639006623 dimerization interface [polypeptide binding]; other site 649639006624 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649639006625 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649639006626 dimer interface [polypeptide binding]; other site 649639006627 putative CheW interface [polypeptide binding]; other site 649639006628 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 649639006629 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639006630 motif II; other site 649639006631 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639006632 CHASE3 domain; Region: CHASE3; cl05000 649639006633 HAMP domain; Region: HAMP; pfam00672 649639006634 dimerization interface [polypeptide binding]; other site 649639006635 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649639006636 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649639006637 dimer interface [polypeptide binding]; other site 649639006638 putative CheW interface [polypeptide binding]; other site 649639006639 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 649639006640 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 649639006641 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649639006642 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 649639006643 substrate binding site [chemical binding]; other site 649639006644 multimerization interface [polypeptide binding]; other site 649639006645 ATP binding site [chemical binding]; other site 649639006646 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 649639006647 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 649639006648 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 649639006649 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 649639006650 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 649639006651 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649639006652 catalytic residue [active] 649639006653 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649639006654 PAS fold; Region: PAS_3; pfam08447 649639006655 putative active site [active] 649639006656 heme pocket [chemical binding]; other site 649639006657 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649639006658 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649639006659 metal binding site [ion binding]; metal-binding site 649639006660 active site 649639006661 I-site; other site 649639006662 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 649639006663 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 649639006664 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649639006665 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649639006666 DNA binding residues [nucleotide binding] 649639006667 dimerization interface [polypeptide binding]; other site 649639006668 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 649639006669 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 649639006670 Peptidase family M23; Region: Peptidase_M23; pfam01551 649639006671 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 649639006672 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 649639006673 active site 649639006674 active site 649639006675 catalytic residues [active] 649639006676 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 649639006677 metal binding site [ion binding]; metal-binding site 649639006678 ligand binding site [chemical binding]; other site 649639006679 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 649639006680 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 649639006681 putative ligand binding site [chemical binding]; other site 649639006682 putative NAD binding site [chemical binding]; other site 649639006683 putative catalytic site [active] 649639006684 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 649639006685 L-serine binding site [chemical binding]; other site 649639006686 ACT domain interface; other site 649639006687 agmatinase; Region: agmatinase; TIGR01230 649639006688 Agmatinase-like family; Region: Agmatinase-like; cd09990 649639006689 active site 649639006690 oligomer interface [polypeptide binding]; other site 649639006691 Mn binding site [ion binding]; other site 649639006692 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 649639006693 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639006694 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649639006695 DNA binding residues [nucleotide binding] 649639006696 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 649639006697 Ligand Binding Site [chemical binding]; other site 649639006698 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 649639006699 active site 649639006700 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 649639006701 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 649639006702 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 649639006703 PLD-like domain; Region: PLDc_2; pfam13091 649639006704 putative active site [active] 649639006705 catalytic site [active] 649639006706 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 649639006707 PLD-like domain; Region: PLDc_2; pfam13091 649639006708 putative active site [active] 649639006709 catalytic site [active] 649639006710 dipeptidase PepV; Reviewed; Region: PRK07318 649639006711 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 649639006712 active site 649639006713 metal binding site [ion binding]; metal-binding site 649639006714 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 649639006715 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639006716 active site 649639006717 motif I; other site 649639006718 motif II; other site 649639006719 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 649639006720 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639006721 Coenzyme A binding pocket [chemical binding]; other site 649639006722 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 649639006723 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 649639006724 metal-binding site [ion binding] 649639006725 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 649639006726 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 649639006727 metal-binding site [ion binding] 649639006728 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 649639006729 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 649639006730 metal-binding site [ion binding] 649639006731 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 649639006732 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639006733 motif II; other site 649639006734 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 649639006735 putative homodimer interface [polypeptide binding]; other site 649639006736 putative homotetramer interface [polypeptide binding]; other site 649639006737 putative allosteric switch controlling residues; other site 649639006738 putative metal binding site [ion binding]; other site 649639006739 putative homodimer-homodimer interface [polypeptide binding]; other site 649639006740 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 649639006741 hydrophobic ligand binding site; other site 649639006742 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649639006743 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649639006744 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 649639006745 Walker A/P-loop; other site 649639006746 ATP binding site [chemical binding]; other site 649639006747 Q-loop/lid; other site 649639006748 ABC transporter signature motif; other site 649639006749 Walker B; other site 649639006750 D-loop; other site 649639006751 H-loop/switch region; other site 649639006752 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649639006753 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 649639006754 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639006755 Walker A/P-loop; other site 649639006756 ATP binding site [chemical binding]; other site 649639006757 Q-loop/lid; other site 649639006758 ABC transporter signature motif; other site 649639006759 Walker B; other site 649639006760 D-loop; other site 649639006761 H-loop/switch region; other site 649639006762 hypothetical protein; Provisional; Region: PRK01844 649639006763 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 649639006764 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 649639006765 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 649639006766 TPP-binding site [chemical binding]; other site 649639006767 dimer interface [polypeptide binding]; other site 649639006768 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 649639006769 PYR/PP interface [polypeptide binding]; other site 649639006770 dimer interface [polypeptide binding]; other site 649639006771 TPP binding site [chemical binding]; other site 649639006772 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 649639006773 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 649639006774 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 649639006775 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 649639006776 catalytic residues [active] 649639006777 catalytic nucleophile [active] 649639006778 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639006779 LexA repressor; Validated; Region: PRK00215 649639006780 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649639006781 putative DNA binding site [nucleotide binding]; other site 649639006782 putative Zn2+ binding site [ion binding]; other site 649639006783 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 649639006784 Catalytic site [active] 649639006785 Transposase; Region: DEDD_Tnp_IS110; pfam01548 649639006786 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 649639006787 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 649639006788 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 649639006789 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 649639006790 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 649639006791 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 649639006792 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 649639006793 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 649639006794 Aluminium resistance protein; Region: Alum_res; pfam06838 649639006795 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 649639006796 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 649639006797 HflX GTPase family; Region: HflX; cd01878 649639006798 G1 box; other site 649639006799 GTP/Mg2+ binding site [chemical binding]; other site 649639006800 Switch I region; other site 649639006801 G2 box; other site 649639006802 G3 box; other site 649639006803 Switch II region; other site 649639006804 G4 box; other site 649639006805 G5 box; other site 649639006806 stage V sporulation protein K; Region: spore_V_K; TIGR02881 649639006807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639006808 Walker A motif; other site 649639006809 ATP binding site [chemical binding]; other site 649639006810 Walker B motif; other site 649639006811 arginine finger; other site 649639006812 bacterial Hfq-like; Region: Hfq; cd01716 649639006813 hexamer interface [polypeptide binding]; other site 649639006814 Sm1 motif; other site 649639006815 RNA binding site [nucleotide binding]; other site 649639006816 Sm2 motif; other site 649639006817 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 649639006818 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 649639006819 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 649639006820 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 649639006821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 649639006822 ATP binding site [chemical binding]; other site 649639006823 Mg2+ binding site [ion binding]; other site 649639006824 G-X-G motif; other site 649639006825 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 649639006826 ATP binding site [chemical binding]; other site 649639006827 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 649639006828 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 649639006829 MutS domain I; Region: MutS_I; pfam01624 649639006830 MutS domain II; Region: MutS_II; pfam05188 649639006831 MutS domain III; Region: MutS_III; pfam05192 649639006832 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 649639006833 Walker A/P-loop; other site 649639006834 ATP binding site [chemical binding]; other site 649639006835 Q-loop/lid; other site 649639006836 ABC transporter signature motif; other site 649639006837 Walker B; other site 649639006838 D-loop; other site 649639006839 H-loop/switch region; other site 649639006840 Phage phiEco32-like COOH.NH2 ligase-type 2; Region: COOH-NH2_lig; pfam14395 649639006841 Outer spore coat protein E (CotE); Region: CotE; pfam10628 649639006842 Predicted membrane protein [Function unknown]; Region: COG4550 649639006843 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 649639006844 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 649639006845 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649639006846 FeS/SAM binding site; other site 649639006847 TRAM domain; Region: TRAM; pfam01938 649639006848 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 649639006849 active site residue [active] 649639006850 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 649639006851 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 649639006852 substrate-cofactor binding pocket; other site 649639006853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639006854 catalytic residue [active] 649639006855 Threonine dehydrogenase; Region: TDH; cd05281 649639006856 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 649639006857 structural Zn binding site [ion binding]; other site 649639006858 catalytic Zn binding site [ion binding]; other site 649639006859 tetramer interface [polypeptide binding]; other site 649639006860 NADP binding site [chemical binding]; other site 649639006861 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 649639006862 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 649639006863 TPP-binding site [chemical binding]; other site 649639006864 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 649639006865 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 649639006866 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 649639006867 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 649639006868 dimer interface [polypeptide binding]; other site 649639006869 PYR/PP interface [polypeptide binding]; other site 649639006870 TPP binding site [chemical binding]; other site 649639006871 substrate binding site [chemical binding]; other site 649639006872 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 649639006873 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 649639006874 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 649639006875 putative active site [active] 649639006876 metal binding site [ion binding]; metal-binding site 649639006877 homodimer binding site [polypeptide binding]; other site 649639006878 phosphodiesterase; Provisional; Region: PRK12704 649639006879 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 649639006880 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 649639006881 Zn2+ binding site [ion binding]; other site 649639006882 Mg2+ binding site [ion binding]; other site 649639006883 recombinase A; Provisional; Region: recA; PRK09354 649639006884 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 649639006885 hexamer interface [polypeptide binding]; other site 649639006886 Walker A motif; other site 649639006887 ATP binding site [chemical binding]; other site 649639006888 Walker B motif; other site 649639006889 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 649639006890 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 649639006891 ATP binding site [chemical binding]; other site 649639006892 Mg++ binding site [ion binding]; other site 649639006893 motif III; other site 649639006894 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649639006895 nucleotide binding region [chemical binding]; other site 649639006896 ATP-binding site [chemical binding]; other site 649639006897 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 649639006898 RNA binding site [nucleotide binding]; other site 649639006899 competence damage-inducible protein A; Provisional; Region: PRK00549 649639006900 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 649639006901 putative MPT binding site; other site 649639006902 Competence-damaged protein; Region: CinA; pfam02464 649639006903 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 649639006904 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 649639006905 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649639006906 non-specific DNA binding site [nucleotide binding]; other site 649639006907 salt bridge; other site 649639006908 sequence-specific DNA binding site [nucleotide binding]; other site 649639006909 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 649639006910 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 649639006911 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 649639006912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649639006913 NAD(P) binding site [chemical binding]; other site 649639006914 active site 649639006915 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 649639006916 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 649639006917 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 649639006918 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 649639006919 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 649639006920 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 649639006921 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 649639006922 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 649639006923 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 649639006924 YlzJ-like protein; Region: YlzJ; pfam14035 649639006925 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 649639006926 Clp protease; Region: CLP_protease; pfam00574 649639006927 active site 649639006928 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 649639006929 dihydrodipicolinate synthase; Region: dapA; TIGR00674 649639006930 dimer interface [polypeptide binding]; other site 649639006931 active site 649639006932 catalytic residue [active] 649639006933 aspartate kinase I; Reviewed; Region: PRK08210 649639006934 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 649639006935 nucleotide binding site [chemical binding]; other site 649639006936 substrate binding site [chemical binding]; other site 649639006937 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 649639006938 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 649639006939 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 649639006940 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 649639006941 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 649639006942 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 649639006943 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 649639006944 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 649639006945 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 649639006946 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 649639006947 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 649639006948 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 649639006949 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 649639006950 NodB motif; other site 649639006951 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 649639006952 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 649639006953 RNase E interface [polypeptide binding]; other site 649639006954 trimer interface [polypeptide binding]; other site 649639006955 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 649639006956 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 649639006957 RNase E interface [polypeptide binding]; other site 649639006958 trimer interface [polypeptide binding]; other site 649639006959 active site 649639006960 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 649639006961 putative nucleic acid binding region [nucleotide binding]; other site 649639006962 G-X-X-G motif; other site 649639006963 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 649639006964 RNA binding site [nucleotide binding]; other site 649639006965 domain interface; other site 649639006966 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 649639006967 16S/18S rRNA binding site [nucleotide binding]; other site 649639006968 S13e-L30e interaction site [polypeptide binding]; other site 649639006969 25S rRNA binding site [nucleotide binding]; other site 649639006970 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 649639006971 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 649639006972 active site 649639006973 Riboflavin kinase; Region: Flavokinase; smart00904 649639006974 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 649639006975 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 649639006976 RNA binding site [nucleotide binding]; other site 649639006977 active site 649639006978 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 649639006979 Protein of unknown function (DUF503); Region: DUF503; pfam04456 649639006980 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 649639006981 translation initiation factor IF-2; Region: IF-2; TIGR00487 649639006982 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 649639006983 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 649639006984 G1 box; other site 649639006985 putative GEF interaction site [polypeptide binding]; other site 649639006986 GTP/Mg2+ binding site [chemical binding]; other site 649639006987 Switch I region; other site 649639006988 G2 box; other site 649639006989 G3 box; other site 649639006990 Switch II region; other site 649639006991 G4 box; other site 649639006992 G5 box; other site 649639006993 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 649639006994 Translation-initiation factor 2; Region: IF-2; pfam11987 649639006995 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 649639006996 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 649639006997 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 649639006998 putative RNA binding cleft [nucleotide binding]; other site 649639006999 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 649639007000 NusA N-terminal domain; Region: NusA_N; pfam08529 649639007001 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 649639007002 RNA binding site [nucleotide binding]; other site 649639007003 homodimer interface [polypeptide binding]; other site 649639007004 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 649639007005 G-X-X-G motif; other site 649639007006 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 649639007007 G-X-X-G motif; other site 649639007008 ribosome maturation protein RimP; Reviewed; Region: PRK00092 649639007009 Sm and related proteins; Region: Sm_like; cl00259 649639007010 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 649639007011 putative oligomer interface [polypeptide binding]; other site 649639007012 putative RNA binding site [nucleotide binding]; other site 649639007013 DNA polymerase III PolC; Validated; Region: polC; PRK00448 649639007014 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 649639007015 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 649639007016 generic binding surface II; other site 649639007017 generic binding surface I; other site 649639007018 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 649639007019 active site 649639007020 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 649639007021 active site 649639007022 catalytic site [active] 649639007023 substrate binding site [chemical binding]; other site 649639007024 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 649639007025 prolyl-tRNA synthetase; Provisional; Region: PRK09194 649639007026 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 649639007027 dimer interface [polypeptide binding]; other site 649639007028 motif 1; other site 649639007029 active site 649639007030 motif 2; other site 649639007031 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 649639007032 putative deacylase active site [active] 649639007033 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 649639007034 active site 649639007035 motif 3; other site 649639007036 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 649639007037 anticodon binding site; other site 649639007038 RIP metalloprotease RseP; Region: TIGR00054 649639007039 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 649639007040 active site 649639007041 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 649639007042 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 649639007043 protein binding site [polypeptide binding]; other site 649639007044 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 649639007045 putative substrate binding region [chemical binding]; other site 649639007046 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 649639007047 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 649639007048 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 649639007049 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 649639007050 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 649639007051 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 649639007052 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 649639007053 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 649639007054 catalytic residue [active] 649639007055 putative FPP diphosphate binding site; other site 649639007056 putative FPP binding hydrophobic cleft; other site 649639007057 dimer interface [polypeptide binding]; other site 649639007058 putative IPP diphosphate binding site; other site 649639007059 ribosome recycling factor; Reviewed; Region: frr; PRK00083 649639007060 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 649639007061 hinge region; other site 649639007062 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 649639007063 putative nucleotide binding site [chemical binding]; other site 649639007064 uridine monophosphate binding site [chemical binding]; other site 649639007065 homohexameric interface [polypeptide binding]; other site 649639007066 elongation factor Ts; Provisional; Region: tsf; PRK09377 649639007067 UBA/TS-N domain; Region: UBA; pfam00627 649639007068 Elongation factor TS; Region: EF_TS; pfam00889 649639007069 Elongation factor TS; Region: EF_TS; pfam00889 649639007070 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 649639007071 rRNA interaction site [nucleotide binding]; other site 649639007072 S8 interaction site; other site 649639007073 putative laminin-1 binding site; other site 649639007074 Protein of unknown function (DUF342); Region: DUF342; pfam03961 649639007075 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 649639007076 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 649639007077 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639007078 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 649639007079 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649639007080 DNA binding residues [nucleotide binding] 649639007081 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 649639007082 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 649639007083 CheC-like family; Region: CheC; pfam04509 649639007084 CheC-like family; Region: CheC; pfam04509 649639007085 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 649639007086 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 649639007087 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 649639007088 putative binding surface; other site 649639007089 active site 649639007090 P2 response regulator binding domain; Region: P2; pfam07194 649639007091 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 649639007092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639007093 ATP binding site [chemical binding]; other site 649639007094 Mg2+ binding site [ion binding]; other site 649639007095 G-X-G motif; other site 649639007096 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 649639007097 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 649639007098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639007099 active site 649639007100 phosphorylation site [posttranslational modification] 649639007101 intermolecular recognition site; other site 649639007102 dimerization interface [polypeptide binding]; other site 649639007103 CheB methylesterase; Region: CheB_methylest; pfam01339 649639007104 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 649639007105 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 649639007106 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 649639007107 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 649639007108 FHIPEP family; Region: FHIPEP; pfam00771 649639007109 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 649639007110 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 649639007111 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 649639007112 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 649639007113 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 649639007114 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 649639007115 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 649639007116 Response regulator receiver domain; Region: Response_reg; pfam00072 649639007117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639007118 active site 649639007119 phosphorylation site [posttranslational modification] 649639007120 intermolecular recognition site; other site 649639007121 dimerization interface [polypeptide binding]; other site 649639007122 flagellar motor switch protein; Validated; Region: PRK08119 649639007123 CheC-like family; Region: CheC; pfam04509 649639007124 CheC-like family; Region: CheC; pfam04509 649639007125 flagellar motor switch protein FliN; Region: fliN; TIGR02480 649639007126 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 649639007127 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 649639007128 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 649639007129 Flagellar protein (FlbD); Region: FlbD; pfam06289 649639007130 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 649639007131 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 649639007132 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 649639007133 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 649639007134 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 649639007135 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 649639007136 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 649639007137 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 649639007138 MgtE intracellular N domain; Region: MgtE_N; pfam03448 649639007139 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 649639007140 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 649639007141 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 649639007142 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 649639007143 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 649639007144 Walker A motif/ATP binding site; other site 649639007145 Walker B motif; other site 649639007146 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 649639007147 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 649639007148 Flagellar assembly protein FliH; Region: FliH; pfam02108 649639007149 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 649639007150 MgtE intracellular N domain; Region: MgtE_N; cl15244 649639007151 FliG C-terminal domain; Region: FliG_C; pfam01706 649639007152 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 649639007153 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 649639007154 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 649639007155 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 649639007156 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 649639007157 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 649639007158 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 649639007159 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 649639007160 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 649639007161 transcriptional repressor CodY; Validated; Region: PRK04158 649639007162 CodY GAF-like domain; Region: CodY; pfam06018 649639007163 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 649639007164 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 649639007165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639007166 Walker A motif; other site 649639007167 ATP binding site [chemical binding]; other site 649639007168 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 649639007169 Walker B motif; other site 649639007170 arginine finger; other site 649639007171 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 649639007172 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 649639007173 active site 649639007174 HslU subunit interaction site [polypeptide binding]; other site 649639007175 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 649639007176 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 649639007177 active site 649639007178 Int/Topo IB signature motif; other site 649639007179 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 649639007180 Glucose inhibited division protein A; Region: GIDA; pfam01134 649639007181 DNA topoisomerase I; Validated; Region: PRK05582 649639007182 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 649639007183 active site 649639007184 interdomain interaction site; other site 649639007185 putative metal-binding site [ion binding]; other site 649639007186 nucleotide binding site [chemical binding]; other site 649639007187 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 649639007188 domain I; other site 649639007189 DNA binding groove [nucleotide binding] 649639007190 phosphate binding site [ion binding]; other site 649639007191 domain II; other site 649639007192 domain III; other site 649639007193 nucleotide binding site [chemical binding]; other site 649639007194 catalytic site [active] 649639007195 domain IV; other site 649639007196 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 649639007197 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 649639007198 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 649639007199 DNA protecting protein DprA; Region: dprA; TIGR00732 649639007200 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 649639007201 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 649639007202 CoA binding domain; Region: CoA_binding; smart00881 649639007203 CoA-ligase; Region: Ligase_CoA; pfam00549 649639007204 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 649639007205 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 649639007206 CoA-ligase; Region: Ligase_CoA; pfam00549 649639007207 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 649639007208 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 649639007209 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 649639007210 RNA/DNA hybrid binding site [nucleotide binding]; other site 649639007211 active site 649639007212 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 649639007213 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 649639007214 GTP/Mg2+ binding site [chemical binding]; other site 649639007215 G4 box; other site 649639007216 G5 box; other site 649639007217 G1 box; other site 649639007218 Switch I region; other site 649639007219 G2 box; other site 649639007220 G3 box; other site 649639007221 Switch II region; other site 649639007222 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 649639007223 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 649639007224 Catalytic site [active] 649639007225 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 649639007226 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 649639007227 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 649639007228 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 649639007229 RimM N-terminal domain; Region: RimM; pfam01782 649639007230 PRC-barrel domain; Region: PRC; pfam05239 649639007231 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 649639007232 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 649639007233 hypothetical protein; Provisional; Region: PRK00468 649639007234 G-X-X-G motif; other site 649639007235 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 649639007236 signal recognition particle protein; Provisional; Region: PRK10867 649639007237 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 649639007238 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 649639007239 P loop; other site 649639007240 GTP binding site [chemical binding]; other site 649639007241 Signal peptide binding domain; Region: SRP_SPB; pfam02978 649639007242 putative DNA-binding protein; Validated; Region: PRK00118 649639007243 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 649639007244 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 649639007245 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 649639007246 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 649639007247 P loop; other site 649639007248 GTP binding site [chemical binding]; other site 649639007249 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 649639007250 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 649639007251 Walker A/P-loop; other site 649639007252 ATP binding site [chemical binding]; other site 649639007253 Q-loop/lid; other site 649639007254 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 649639007255 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 649639007256 ABC transporter signature motif; other site 649639007257 Walker B; other site 649639007258 D-loop; other site 649639007259 H-loop/switch region; other site 649639007260 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 649639007261 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 649639007262 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 649639007263 dimerization interface [polypeptide binding]; other site 649639007264 active site 649639007265 metal binding site [ion binding]; metal-binding site 649639007266 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 649639007267 dsRNA binding site [nucleotide binding]; other site 649639007268 acyl carrier protein; Provisional; Region: acpP; PRK00982 649639007269 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 649639007270 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 649639007271 NAD(P) binding site [chemical binding]; other site 649639007272 homotetramer interface [polypeptide binding]; other site 649639007273 homodimer interface [polypeptide binding]; other site 649639007274 active site 649639007275 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 649639007276 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649639007277 putative phosphate acyltransferase; Provisional; Region: PRK05331 649639007278 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 649639007279 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 649639007280 active site 2 [active] 649639007281 active site 1 [active] 649639007282 Y-family of DNA polymerases; Region: PolY; cl12025 649639007283 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 649639007284 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 649639007285 generic binding surface II; other site 649639007286 ssDNA binding site; other site 649639007287 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649639007288 ATP binding site [chemical binding]; other site 649639007289 putative Mg++ binding site [ion binding]; other site 649639007290 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649639007291 nucleotide binding region [chemical binding]; other site 649639007292 ATP-binding site [chemical binding]; other site 649639007293 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 649639007294 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 649639007295 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 649639007296 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 649639007297 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 649639007298 putative L-serine binding site [chemical binding]; other site 649639007299 EDD domain protein, DegV family; Region: DegV; TIGR00762 649639007300 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 649639007301 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 649639007302 DAK2 domain; Region: Dak2; pfam02734 649639007303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 649639007304 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 649639007305 Stage V sporulation protein family; Region: SpoV; cl15455 649639007306 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 649639007307 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 649639007308 substrate binding site [chemical binding]; other site 649639007309 hexamer interface [polypeptide binding]; other site 649639007310 metal binding site [ion binding]; metal-binding site 649639007311 GTPase RsgA; Reviewed; Region: PRK00098 649639007312 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 649639007313 RNA binding site [nucleotide binding]; other site 649639007314 homodimer interface [polypeptide binding]; other site 649639007315 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 649639007316 GTPase/Zn-binding domain interface [polypeptide binding]; other site 649639007317 GTP/Mg2+ binding site [chemical binding]; other site 649639007318 G4 box; other site 649639007319 G5 box; other site 649639007320 G1 box; other site 649639007321 Switch I region; other site 649639007322 G2 box; other site 649639007323 G3 box; other site 649639007324 Switch II region; other site 649639007325 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649639007326 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649639007327 active site 649639007328 ATP binding site [chemical binding]; other site 649639007329 substrate binding site [chemical binding]; other site 649639007330 activation loop (A-loop); other site 649639007331 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 649639007332 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 649639007333 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 649639007334 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 649639007335 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 649639007336 active site 649639007337 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 649639007338 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649639007339 FeS/SAM binding site; other site 649639007340 16S rRNA methyltransferase B; Provisional; Region: PRK14902 649639007341 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 649639007342 putative RNA binding site [nucleotide binding]; other site 649639007343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639007344 S-adenosylmethionine binding site [chemical binding]; other site 649639007345 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 649639007346 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 649639007347 putative active site [active] 649639007348 substrate binding site [chemical binding]; other site 649639007349 putative cosubstrate binding site; other site 649639007350 catalytic site [active] 649639007351 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 649639007352 substrate binding site [chemical binding]; other site 649639007353 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649639007354 primosomal protein N' Region: priA; TIGR00595 649639007355 ATP binding site [chemical binding]; other site 649639007356 putative Mg++ binding site [ion binding]; other site 649639007357 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649639007358 nucleotide binding region [chemical binding]; other site 649639007359 ATP-binding site [chemical binding]; other site 649639007360 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 649639007361 Flavoprotein; Region: Flavoprotein; pfam02441 649639007362 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 649639007363 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 649639007364 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 649639007365 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 649639007366 catalytic site [active] 649639007367 G-X2-G-X-G-K; other site 649639007368 hypothetical protein; Provisional; Region: PRK04323 649639007369 hypothetical protein; Provisional; Region: PRK11820 649639007370 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 649639007371 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 649639007372 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 649639007373 Domain of unknown function (DUF814); Region: DUF814; pfam05670 649639007374 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649639007375 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649639007376 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 649639007377 Walker A/P-loop; other site 649639007378 ATP binding site [chemical binding]; other site 649639007379 Q-loop/lid; other site 649639007380 ABC transporter signature motif; other site 649639007381 Walker B; other site 649639007382 D-loop; other site 649639007383 H-loop/switch region; other site 649639007384 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649639007385 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649639007386 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 649639007387 Walker A/P-loop; other site 649639007388 ATP binding site [chemical binding]; other site 649639007389 Q-loop/lid; other site 649639007390 ABC transporter signature motif; other site 649639007391 Walker B; other site 649639007392 D-loop; other site 649639007393 H-loop/switch region; other site 649639007394 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 649639007395 active site 649639007396 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 649639007397 active site 649639007398 dimer interface [polypeptide binding]; other site 649639007399 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 649639007400 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 649639007401 heterodimer interface [polypeptide binding]; other site 649639007402 active site 649639007403 FMN binding site [chemical binding]; other site 649639007404 homodimer interface [polypeptide binding]; other site 649639007405 substrate binding site [chemical binding]; other site 649639007406 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 649639007407 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 649639007408 FAD binding pocket [chemical binding]; other site 649639007409 FAD binding motif [chemical binding]; other site 649639007410 phosphate binding motif [ion binding]; other site 649639007411 beta-alpha-beta structure motif; other site 649639007412 NAD binding pocket [chemical binding]; other site 649639007413 Iron coordination center [ion binding]; other site 649639007414 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 649639007415 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 649639007416 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 649639007417 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 649639007418 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 649639007419 ATP-grasp domain; Region: ATP-grasp_4; cl17255 649639007420 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 649639007421 IMP binding site; other site 649639007422 dimer interface [polypeptide binding]; other site 649639007423 interdomain contacts; other site 649639007424 partial ornithine binding site; other site 649639007425 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 649639007426 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 649639007427 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 649639007428 catalytic site [active] 649639007429 subunit interface [polypeptide binding]; other site 649639007430 dihydroorotase; Validated; Region: pyrC; PRK09357 649639007431 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649639007432 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 649639007433 active site 649639007434 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 649639007435 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 649639007436 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 649639007437 uracil transporter; Provisional; Region: PRK10720 649639007438 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 649639007439 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 649639007440 active site 649639007441 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 649639007442 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 649639007443 RNA binding surface [nucleotide binding]; other site 649639007444 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 649639007445 active site 649639007446 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 649639007447 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 649639007448 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 649639007449 HIGH motif; other site 649639007450 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 649639007451 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 649639007452 active site 649639007453 KMSKS motif; other site 649639007454 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 649639007455 tRNA binding surface [nucleotide binding]; other site 649639007456 anticodon binding site; other site 649639007457 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 649639007458 DivIVA protein; Region: DivIVA; pfam05103 649639007459 DivIVA domain; Region: DivI1A_domain; TIGR03544 649639007460 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 649639007461 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 649639007462 RNA binding surface [nucleotide binding]; other site 649639007463 YGGT family; Region: YGGT; pfam02325 649639007464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 649639007465 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 649639007466 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 649639007467 catalytic residue [active] 649639007468 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 649639007469 sporulation sigma factor SigG; Reviewed; Region: PRK08215 649639007470 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639007471 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 649639007472 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649639007473 DNA binding residues [nucleotide binding] 649639007474 sporulation sigma factor SigE; Reviewed; Region: PRK08301 649639007475 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639007476 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649639007477 DNA binding residues [nucleotide binding] 649639007478 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 649639007479 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 649639007480 cell division protein FtsZ; Validated; Region: PRK09330 649639007481 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 649639007482 nucleotide binding site [chemical binding]; other site 649639007483 SulA interaction site; other site 649639007484 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 649639007485 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 649639007486 nucleotide binding site [chemical binding]; other site 649639007487 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 649639007488 Cell division protein FtsA; Region: FtsA; pfam14450 649639007489 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 649639007490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 649639007491 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 649639007492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 649639007493 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 649639007494 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 649639007495 Cell division protein FtsQ; Region: FtsQ; pfam03799 649639007496 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 649639007497 FAD binding domain; Region: FAD_binding_4; pfam01565 649639007498 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 649639007499 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 649639007500 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 649639007501 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 649639007502 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 649639007503 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 649639007504 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 649639007505 Mg++ binding site [ion binding]; other site 649639007506 putative catalytic motif [active] 649639007507 putative substrate binding site [chemical binding]; other site 649639007508 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 649639007509 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 649639007510 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 649639007511 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 649639007512 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 649639007513 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 649639007514 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 649639007515 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 649639007516 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 649639007517 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 649639007518 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 649639007519 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 649639007520 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 649639007521 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 649639007522 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 649639007523 Cell division protein FtsL; Region: FtsL; cl11433 649639007524 MraW methylase family; Region: Methyltransf_5; pfam01795 649639007525 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 649639007526 cell division protein MraZ; Reviewed; Region: PRK00326 649639007527 MraZ protein; Region: MraZ; pfam02381 649639007528 MraZ protein; Region: MraZ; pfam02381 649639007529 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 649639007530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 649639007531 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 649639007532 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 649639007533 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 649639007534 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 649639007535 hypothetical protein; Provisional; Region: PRK13688 649639007536 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639007537 Coenzyme A binding pocket [chemical binding]; other site 649639007538 Transposase; Region: DEDD_Tnp_IS110; pfam01548 649639007539 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 649639007540 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 649639007541 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 649639007542 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 649639007543 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 649639007544 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 649639007545 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 649639007546 hypothetical protein; Provisional; Region: PRK13670 649639007547 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 649639007548 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 649639007549 protein binding site [polypeptide binding]; other site 649639007550 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 649639007551 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 649639007552 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 649639007553 active site 649639007554 nucleophile elbow; other site 649639007555 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 649639007556 Nucleoside recognition; Region: Gate; pfam07670 649639007557 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 649639007558 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 649639007559 active site 649639007560 (T/H)XGH motif; other site 649639007561 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 649639007562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639007563 S-adenosylmethionine binding site [chemical binding]; other site 649639007564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639007565 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649639007566 putative substrate translocation pore; other site 649639007567 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 649639007568 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 649639007569 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 649639007570 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 649639007571 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649639007572 ATP binding site [chemical binding]; other site 649639007573 putative Mg++ binding site [ion binding]; other site 649639007574 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649639007575 nucleotide binding region [chemical binding]; other site 649639007576 ATP-binding site [chemical binding]; other site 649639007577 YlbE-like protein; Region: YlbE; pfam14003 649639007578 Putative coat protein; Region: YlbD_coat; pfam14071 649639007579 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 649639007580 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 649639007581 FOG: CBS domain [General function prediction only]; Region: COG0517 649639007582 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 649639007583 YugN-like family; Region: YugN; pfam08868 649639007584 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 649639007585 Domain of unknown function DUF20; Region: UPF0118; pfam01594 649639007586 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 649639007587 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 649639007588 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 649639007589 Protein of unknown function (DUF458); Region: DUF458; pfam04308 649639007590 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639007591 Walker A/P-loop; other site 649639007592 ATP binding site [chemical binding]; other site 649639007593 ABC transporter; Region: ABC_tran; pfam00005 649639007594 Q-loop/lid; other site 649639007595 ABC transporter signature motif; other site 649639007596 Walker B; other site 649639007597 D-loop; other site 649639007598 Predicted transcriptional regulators [Transcription]; Region: COG1725 649639007599 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649639007600 DNA-binding site [nucleotide binding]; DNA binding site 649639007601 Protein of unknown function (DUF420); Region: DUF420; pfam04238 649639007602 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 649639007603 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 649639007604 Subunit I/III interface [polypeptide binding]; other site 649639007605 Subunit III/IV interface [polypeptide binding]; other site 649639007606 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 649639007607 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 649639007608 D-pathway; other site 649639007609 Putative ubiquinol binding site [chemical binding]; other site 649639007610 Low-spin heme (heme b) binding site [chemical binding]; other site 649639007611 Putative water exit pathway; other site 649639007612 Binuclear center (heme o3/CuB) [ion binding]; other site 649639007613 K-pathway; other site 649639007614 Putative proton exit pathway; other site 649639007615 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 649639007616 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 649639007617 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 649639007618 Cytochrome c; Region: Cytochrom_C; pfam00034 649639007619 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 649639007620 UbiA prenyltransferase family; Region: UbiA; pfam01040 649639007621 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 649639007622 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 649639007623 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 649639007624 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 649639007625 dimerization interface [polypeptide binding]; other site 649639007626 DPS ferroxidase diiron center [ion binding]; other site 649639007627 ion pore; other site 649639007628 hypothetical protein; Provisional; Region: PRK13666 649639007629 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 649639007630 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 649639007631 putative active site [active] 649639007632 PhoH-like protein; Region: PhoH; pfam02562 649639007633 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 649639007634 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 649639007635 hypothetical protein; Provisional; Region: PRK06733 649639007636 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 649639007637 YlaH-like protein; Region: YlaH; pfam14036 649639007638 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 649639007639 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 649639007640 active site 649639007641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 649639007642 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 649639007643 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 649639007644 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 649639007645 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 649639007646 homodimer interface [polypeptide binding]; other site 649639007647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639007648 catalytic residue [active] 649639007649 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 649639007650 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 649639007651 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 649639007652 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 649639007653 Peptidase family M23; Region: Peptidase_M23; pfam01551 649639007654 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 649639007655 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 649639007656 NodB motif; other site 649639007657 active site 649639007658 catalytic site [active] 649639007659 metal binding site [ion binding]; metal-binding site 649639007660 BCCT family transporter; Region: BCCT; pfam02028 649639007661 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 649639007662 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 649639007663 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649639007664 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 649639007665 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 649639007666 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 649639007667 E3 interaction surface; other site 649639007668 lipoyl attachment site [posttranslational modification]; other site 649639007669 e3 binding domain; Region: E3_binding; pfam02817 649639007670 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 649639007671 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 649639007672 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 649639007673 alpha subunit interface [polypeptide binding]; other site 649639007674 TPP binding site [chemical binding]; other site 649639007675 heterodimer interface [polypeptide binding]; other site 649639007676 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 649639007677 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 649639007678 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 649639007679 TPP-binding site [chemical binding]; other site 649639007680 heterodimer interface [polypeptide binding]; other site 649639007681 tetramer interface [polypeptide binding]; other site 649639007682 phosphorylation loop region [posttranslational modification] 649639007683 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 649639007684 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 649639007685 active site 649639007686 catalytic residues [active] 649639007687 metal binding site [ion binding]; metal-binding site 649639007688 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639007689 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 649639007690 active site 649639007691 motif I; other site 649639007692 motif II; other site 649639007693 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639007694 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 649639007695 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 649639007696 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 649639007697 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 649639007698 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 649639007699 TrkA-N domain; Region: TrkA_N; pfam02254 649639007700 TrkA-C domain; Region: TrkA_C; pfam02080 649639007701 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 649639007702 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 649639007703 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 649639007704 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 649639007705 dimer interface [polypeptide binding]; other site 649639007706 decamer (pentamer of dimers) interface [polypeptide binding]; other site 649639007707 catalytic triad [active] 649639007708 peroxidatic and resolving cysteines [active] 649639007709 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 649639007710 Mechanosensitive ion channel; Region: MS_channel; pfam00924 649639007711 hypothetical protein; Provisional; Region: PRK03094 649639007712 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 649639007713 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 649639007714 metal binding site [ion binding]; metal-binding site 649639007715 putative dimer interface [polypeptide binding]; other site 649639007716 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 649639007717 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 649639007718 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 649639007719 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 649639007720 putative CoA binding site [chemical binding]; other site 649639007721 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 649639007722 catalytic residues [active] 649639007723 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 649639007724 Mechanosensitive ion channel; Region: MS_channel; pfam00924 649639007725 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649639007726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639007727 Walker A/P-loop; other site 649639007728 ATP binding site [chemical binding]; other site 649639007729 Q-loop/lid; other site 649639007730 ABC transporter signature motif; other site 649639007731 Walker B; other site 649639007732 D-loop; other site 649639007733 H-loop/switch region; other site 649639007734 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 649639007735 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 649639007736 putative dimer interface [polypeptide binding]; other site 649639007737 YppG-like protein; Region: YppG; pfam14179 649639007738 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 649639007739 dimer interface [polypeptide binding]; other site 649639007740 FMN binding site [chemical binding]; other site 649639007741 NADPH bind site [chemical binding]; other site 649639007742 S-ribosylhomocysteinase; Provisional; Region: PRK02260 649639007743 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 649639007744 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 649639007745 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 649639007746 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 649639007747 Predicted transcriptional regulators [Transcription]; Region: COG1695 649639007748 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 649639007749 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649639007750 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 649639007751 putative active site [active] 649639007752 nucleotide binding site [chemical binding]; other site 649639007753 nudix motif; other site 649639007754 putative metal binding site [ion binding]; other site 649639007755 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 649639007756 conserved cys residue [active] 649639007757 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649639007758 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649639007759 Coenzyme A binding pocket [chemical binding]; other site 649639007760 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 649639007761 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639007762 Coenzyme A binding pocket [chemical binding]; other site 649639007763 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 649639007764 tetramer interfaces [polypeptide binding]; other site 649639007765 binuclear metal-binding site [ion binding]; other site 649639007766 Replication-relaxation; Region: Replic_Relax; pfam13814 649639007767 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 649639007768 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 649639007769 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 649639007770 Mg binding site [ion binding]; other site 649639007771 nucleotide binding site [chemical binding]; other site 649639007772 putative protofilament interface [polypeptide binding]; other site 649639007773 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649639007774 sequence-specific DNA binding site [nucleotide binding]; other site 649639007775 salt bridge; other site 649639007776 Restriction endonuclease; Region: Mrr_cat; pfam04471 649639007777 Helix-turn-helix domain; Region: HTH_17; cl17695 649639007778 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 649639007779 Phage tail protein; Region: Sipho_tail; pfam05709 649639007780 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 649639007781 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 649639007782 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 649639007783 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 649639007784 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 649639007785 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 649639007786 oligomerization interface [polypeptide binding]; other site 649639007787 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 649639007788 Phage capsid family; Region: Phage_capsid; pfam05065 649639007789 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 649639007790 oligomer interface [polypeptide binding]; other site 649639007791 Clp protease; Region: CLP_protease; pfam00574 649639007792 active site residues [active] 649639007793 Phage portal protein; Region: Phage_portal; pfam04860 649639007794 Phage-related protein [Function unknown]; Region: COG4695 649639007795 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 649639007796 Phage terminase, small subunit; Region: Terminase_4; pfam05119 649639007797 HNH endonuclease; Region: HNH; pfam01844 649639007798 active site 649639007799 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 649639007800 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 649639007801 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639007802 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 649639007803 Walker A motif; other site 649639007804 ATP binding site [chemical binding]; other site 649639007805 Walker B motif; other site 649639007806 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 649639007807 Helix-turn-helix domain; Region: HTH_17; pfam12728 649639007808 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649639007809 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649639007810 non-specific DNA binding site [nucleotide binding]; other site 649639007811 salt bridge; other site 649639007812 sequence-specific DNA binding site [nucleotide binding]; other site 649639007813 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649639007814 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649639007815 non-specific DNA binding site [nucleotide binding]; other site 649639007816 salt bridge; other site 649639007817 sequence-specific DNA binding site [nucleotide binding]; other site 649639007818 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 649639007819 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 649639007820 Int/Topo IB signature motif; other site 649639007821 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 649639007822 active site 649639007823 catalytic triad [active] 649639007824 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 649639007825 Fasciclin domain; Region: Fasciclin; pfam02469 649639007826 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 649639007827 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649639007828 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 649639007829 Walker A/P-loop; other site 649639007830 ATP binding site [chemical binding]; other site 649639007831 Q-loop/lid; other site 649639007832 ABC transporter signature motif; other site 649639007833 Walker B; other site 649639007834 D-loop; other site 649639007835 H-loop/switch region; other site 649639007836 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 649639007837 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 649639007838 FtsX-like permease family; Region: FtsX; pfam02687 649639007839 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 649639007840 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 649639007841 FtsX-like permease family; Region: FtsX; pfam02687 649639007842 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649639007843 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 649639007844 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639007845 Walker A/P-loop; other site 649639007846 ATP binding site [chemical binding]; other site 649639007847 Q-loop/lid; other site 649639007848 ABC transporter signature motif; other site 649639007849 Walker B; other site 649639007850 D-loop; other site 649639007851 H-loop/switch region; other site 649639007852 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 649639007853 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 649639007854 active site 649639007855 catalytic residues [active] 649639007856 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649639007857 Beta-lactamase; Region: Beta-lactamase; pfam00144 649639007858 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 649639007859 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 649639007860 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 649639007861 Uncharacterized conserved protein [Function unknown]; Region: COG1359 649639007862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 649639007863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 649639007864 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 649639007865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639007866 dimer interface [polypeptide binding]; other site 649639007867 conserved gate region; other site 649639007868 putative PBP binding loops; other site 649639007869 ABC-ATPase subunit interface; other site 649639007870 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 649639007871 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 649639007872 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 649639007873 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 649639007874 Predicted membrane protein [Function unknown]; Region: COG2323 649639007875 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649639007876 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649639007877 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 649639007878 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 649639007879 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 649639007880 TM-ABC transporter signature motif; other site 649639007881 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 649639007882 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 649639007883 Walker A/P-loop; other site 649639007884 ATP binding site [chemical binding]; other site 649639007885 Q-loop/lid; other site 649639007886 ABC transporter signature motif; other site 649639007887 Walker B; other site 649639007888 D-loop; other site 649639007889 H-loop/switch region; other site 649639007890 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 649639007891 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 649639007892 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 649639007893 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649639007894 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649639007895 DNA binding site [nucleotide binding] 649639007896 domain linker motif; other site 649639007897 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 649639007898 ligand binding site [chemical binding]; other site 649639007899 dimerization interface [polypeptide binding]; other site 649639007900 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 649639007901 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 649639007902 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 649639007903 hypothetical protein; Provisional; Region: PRK11479 649639007904 Hemerythrin-like domain; Region: Hr-like; cd12108 649639007905 Fe binding site [ion binding]; other site 649639007906 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 649639007907 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 649639007908 N-acetyl-D-glucosamine binding site [chemical binding]; other site 649639007909 catalytic residue [active] 649639007910 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 649639007911 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 649639007912 putative active site [active] 649639007913 putative NTP binding site [chemical binding]; other site 649639007914 putative nucleic acid binding site [nucleotide binding]; other site 649639007915 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 649639007916 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 649639007917 Nicotianamine synthase protein; Region: NAS; cl17658 649639007918 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 649639007919 ferrous iron transporter FeoB; Region: feoB; TIGR00437 649639007920 G1 box; other site 649639007921 GTP/Mg2+ binding site [chemical binding]; other site 649639007922 G2 box; other site 649639007923 Switch I region; other site 649639007924 G3 box; other site 649639007925 Switch II region; other site 649639007926 G4 box; other site 649639007927 G5 box; other site 649639007928 Nucleoside recognition; Region: Gate; pfam07670 649639007929 Nucleoside recognition; Region: Gate; pfam07670 649639007930 FeoA domain; Region: FeoA; pfam04023 649639007931 Transcriptional regulator PadR-like family; Region: PadR; cl17335 649639007932 Predicted transcriptional regulators [Transcription]; Region: COG1695 649639007933 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 649639007934 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 649639007935 Chromate transporter; Region: Chromate_transp; pfam02417 649639007936 hypothetical protein; Validated; Region: PRK07708 649639007937 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 649639007938 RNA/DNA hybrid binding site [nucleotide binding]; other site 649639007939 active site 649639007940 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 649639007941 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 649639007942 FMN binding site [chemical binding]; other site 649639007943 substrate binding site [chemical binding]; other site 649639007944 putative catalytic residue [active] 649639007945 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 649639007946 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 649639007947 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 649639007948 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 649639007949 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649639007950 DNA-binding site [nucleotide binding]; DNA binding site 649639007951 UTRA domain; Region: UTRA; pfam07702 649639007952 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 649639007953 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 649639007954 NAD binding site [chemical binding]; other site 649639007955 sugar binding site [chemical binding]; other site 649639007956 divalent metal binding site [ion binding]; other site 649639007957 tetramer (dimer of dimers) interface [polypeptide binding]; other site 649639007958 dimer interface [polypeptide binding]; other site 649639007959 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 649639007960 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 649639007961 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 649639007962 active site 649639007963 DNA topoisomerase III; Provisional; Region: PRK07726 649639007964 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 649639007965 active site 649639007966 putative interdomain interaction site [polypeptide binding]; other site 649639007967 putative metal-binding site [ion binding]; other site 649639007968 putative nucleotide binding site [chemical binding]; other site 649639007969 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 649639007970 domain I; other site 649639007971 DNA binding groove [nucleotide binding] 649639007972 phosphate binding site [ion binding]; other site 649639007973 domain II; other site 649639007974 domain III; other site 649639007975 nucleotide binding site [chemical binding]; other site 649639007976 catalytic site [active] 649639007977 domain IV; other site 649639007978 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 649639007979 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 649639007980 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 649639007981 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 649639007982 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 649639007983 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639007984 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649639007985 DNA binding residues [nucleotide binding] 649639007986 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 649639007987 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 649639007988 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 649639007989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639007990 dimer interface [polypeptide binding]; other site 649639007991 conserved gate region; other site 649639007992 putative PBP binding loops; other site 649639007993 ABC-ATPase subunit interface; other site 649639007994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639007995 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 649639007996 Walker A/P-loop; other site 649639007997 ATP binding site [chemical binding]; other site 649639007998 Q-loop/lid; other site 649639007999 ABC transporter signature motif; other site 649639008000 Walker B; other site 649639008001 D-loop; other site 649639008002 H-loop/switch region; other site 649639008003 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 649639008004 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649639008005 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 649639008006 Walker A/P-loop; other site 649639008007 ATP binding site [chemical binding]; other site 649639008008 Q-loop/lid; other site 649639008009 ABC transporter signature motif; other site 649639008010 Walker B; other site 649639008011 D-loop; other site 649639008012 H-loop/switch region; other site 649639008013 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 649639008014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649639008015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649639008016 Acylphosphatase; Region: Acylphosphatase; pfam00708 649639008017 39S mitochondrial ribosomal protein L46; Region: MRP-L46; pfam11788 649639008018 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 649639008019 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 649639008020 aspartate racemase; Region: asp_race; TIGR00035 649639008021 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 649639008022 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 649639008023 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 649639008024 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 649639008025 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 649639008026 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 649639008027 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 649639008028 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 649639008029 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 649639008030 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 649639008031 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 649639008032 active site 649639008033 ATP binding site [chemical binding]; other site 649639008034 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 649639008035 putative ADP-binding pocket [chemical binding]; other site 649639008036 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 649639008037 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 649639008038 active site 649639008039 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 649639008040 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 649639008041 active site 649639008042 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 649639008043 active site 649639008044 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649639008045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649639008046 NAD(P) binding site [chemical binding]; other site 649639008047 active site 649639008048 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 649639008049 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 649639008050 UbiA prenyltransferase family; Region: UbiA; pfam01040 649639008051 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 649639008052 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 649639008053 inhibitor-cofactor binding pocket; inhibition site 649639008054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639008055 catalytic residue [active] 649639008056 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 649639008057 Peptidase family U32; Region: Peptidase_U32; pfam01136 649639008058 Peptidase family U32; Region: Peptidase_U32; cl03113 649639008059 Erythromycin esterase; Region: Erythro_esteras; pfam05139 649639008060 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 649639008061 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639008062 motif II; other site 649639008063 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 649639008064 short chain dehydrogenase; Provisional; Region: PRK08309 649639008065 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 649639008066 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 649639008067 N- and C-terminal domain interface [polypeptide binding]; other site 649639008068 active site 649639008069 catalytic site [active] 649639008070 metal binding site [ion binding]; metal-binding site 649639008071 carbohydrate binding site [chemical binding]; other site 649639008072 ATP binding site [chemical binding]; other site 649639008073 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 649639008074 isocitrate dehydrogenase; Validated; Region: PRK09222 649639008075 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 649639008076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639008077 S-adenosylmethionine binding site [chemical binding]; other site 649639008078 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 649639008079 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639008080 Coenzyme A binding pocket [chemical binding]; other site 649639008081 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 649639008082 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 649639008083 active site 649639008084 NTP binding site [chemical binding]; other site 649639008085 metal binding triad [ion binding]; metal-binding site 649639008086 antibiotic binding site [chemical binding]; other site 649639008087 Predicted membrane protein [Function unknown]; Region: COG2364 649639008088 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 649639008089 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 649639008090 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639008091 motif II; other site 649639008092 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 649639008093 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 649639008094 active site 649639008095 catalytic residue [active] 649639008096 dimer interface [polypeptide binding]; other site 649639008097 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 649639008098 VanW like protein; Region: VanW; pfam04294 649639008099 EamA-like transporter family; Region: EamA; pfam00892 649639008100 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 649639008101 EamA-like transporter family; Region: EamA; pfam00892 649639008102 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 649639008103 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 649639008104 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 649639008105 Walker A/P-loop; other site 649639008106 ATP binding site [chemical binding]; other site 649639008107 Q-loop/lid; other site 649639008108 ABC transporter signature motif; other site 649639008109 Walker B; other site 649639008110 D-loop; other site 649639008111 H-loop/switch region; other site 649639008112 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 649639008113 Walker A/P-loop; other site 649639008114 ATP binding site [chemical binding]; other site 649639008115 Q-loop/lid; other site 649639008116 ABC transporter signature motif; other site 649639008117 Walker B; other site 649639008118 D-loop; other site 649639008119 H-loop/switch region; other site 649639008120 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 649639008121 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 649639008122 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 649639008123 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 649639008124 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 649639008125 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 649639008126 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 649639008127 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 649639008128 hexamer interface [polypeptide binding]; other site 649639008129 ligand binding site [chemical binding]; other site 649639008130 putative active site [active] 649639008131 NAD(P) binding site [chemical binding]; other site 649639008132 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 649639008133 YpjP-like protein; Region: YpjP; pfam14005 649639008134 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 649639008135 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649639008136 dimerization interface [polypeptide binding]; other site 649639008137 putative DNA binding site [nucleotide binding]; other site 649639008138 putative Zn2+ binding site [ion binding]; other site 649639008139 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 649639008140 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 649639008141 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 649639008142 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 649639008143 Protein of unknown function DUF58; Region: DUF58; pfam01882 649639008144 MoxR-like ATPases [General function prediction only]; Region: COG0714 649639008145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639008146 Walker A motif; other site 649639008147 ATP binding site [chemical binding]; other site 649639008148 Walker B motif; other site 649639008149 arginine finger; other site 649639008150 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 649639008151 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 649639008152 putative oligomer interface [polypeptide binding]; other site 649639008153 putative active site [active] 649639008154 metal binding site [ion binding]; metal-binding site 649639008155 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 649639008156 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 649639008157 dimer interface [polypeptide binding]; other site 649639008158 active site 649639008159 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 649639008160 active site 649639008161 Predicted membrane protein [Function unknown]; Region: COG2259 649639008162 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 649639008163 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649639008164 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 649639008165 NAD(P) binding site [chemical binding]; other site 649639008166 active site 649639008167 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 649639008168 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 649639008169 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 649639008170 putative active site [active] 649639008171 putative NTP binding site [chemical binding]; other site 649639008172 putative nucleic acid binding site [nucleotide binding]; other site 649639008173 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 649639008174 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 649639008175 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 649639008176 NAD binding site [chemical binding]; other site 649639008177 homotetramer interface [polypeptide binding]; other site 649639008178 homodimer interface [polypeptide binding]; other site 649639008179 substrate binding site [chemical binding]; other site 649639008180 active site 649639008181 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 649639008182 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 649639008183 active site 649639008184 metal binding site [ion binding]; metal-binding site 649639008185 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 649639008186 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 649639008187 active site 649639008188 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 649639008189 ATP-NAD kinase; Region: NAD_kinase; pfam01513 649639008190 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 649639008191 synthetase active site [active] 649639008192 NTP binding site [chemical binding]; other site 649639008193 metal binding site [ion binding]; metal-binding site 649639008194 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 649639008195 putative active site [active] 649639008196 putative metal binding residues [ion binding]; other site 649639008197 signature motif; other site 649639008198 putative triphosphate binding site [ion binding]; other site 649639008199 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 649639008200 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 649639008201 N-acetyl-D-glucosamine binding site [chemical binding]; other site 649639008202 catalytic residue [active] 649639008203 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 649639008204 apolar tunnel; other site 649639008205 heme binding site [chemical binding]; other site 649639008206 dimerization interface [polypeptide binding]; other site 649639008207 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 649639008208 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 649639008209 catalytic residues [active] 649639008210 oligoendopeptidase F; Region: pepF; TIGR00181 649639008211 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 649639008212 active site 649639008213 Zn binding site [ion binding]; other site 649639008214 Competence protein CoiA-like family; Region: CoiA; cl11541 649639008215 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 649639008216 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 649639008217 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 649639008218 putative active site [active] 649639008219 catalytic site [active] 649639008220 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 649639008221 putative active site [active] 649639008222 catalytic site [active] 649639008223 adaptor protein; Provisional; Region: PRK02315 649639008224 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 649639008225 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 649639008226 ArsC family; Region: ArsC; pfam03960 649639008227 putative catalytic residues [active] 649639008228 thiol/disulfide switch; other site 649639008229 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 649639008230 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 649639008231 Zn2+ binding site [ion binding]; other site 649639008232 Mg2+ binding site [ion binding]; other site 649639008233 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 649639008234 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 649639008235 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 649639008236 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 649639008237 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 649639008238 catalytic residues [active] 649639008239 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 649639008240 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 649639008241 active site 649639008242 HIGH motif; other site 649639008243 dimer interface [polypeptide binding]; other site 649639008244 KMSKS motif; other site 649639008245 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 649639008246 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 649639008247 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 649639008248 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 649639008249 ligand binding site [chemical binding]; other site 649639008250 flexible hinge region; other site 649639008251 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 649639008252 non-specific DNA interactions [nucleotide binding]; other site 649639008253 DNA binding site [nucleotide binding] 649639008254 sequence specific DNA binding site [nucleotide binding]; other site 649639008255 putative cAMP binding site [chemical binding]; other site 649639008256 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649639008257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639008258 active site 649639008259 phosphorylation site [posttranslational modification] 649639008260 intermolecular recognition site; other site 649639008261 dimerization interface [polypeptide binding]; other site 649639008262 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649639008263 DNA binding residues [nucleotide binding] 649639008264 dimerization interface [polypeptide binding]; other site 649639008265 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649639008266 Histidine kinase; Region: HisKA_3; pfam07730 649639008267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639008268 ATP binding site [chemical binding]; other site 649639008269 Mg2+ binding site [ion binding]; other site 649639008270 G-X-G motif; other site 649639008271 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 649639008272 Transcriptional regulator [Transcription]; Region: LytR; COG1316 649639008273 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 649639008274 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 649639008275 dimer interface [polypeptide binding]; other site 649639008276 active site 649639008277 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 649639008278 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 649639008279 dimer interface [polypeptide binding]; other site 649639008280 active site 649639008281 CoA binding pocket [chemical binding]; other site 649639008282 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 649639008283 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 649639008284 putative ligand binding site [chemical binding]; other site 649639008285 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649639008286 YwiC-like protein; Region: YwiC; pfam14256 649639008287 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 649639008288 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 649639008289 ligand binding site [chemical binding]; other site 649639008290 flexible hinge region; other site 649639008291 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 649639008292 putative switch regulator; other site 649639008293 non-specific DNA interactions [nucleotide binding]; other site 649639008294 DNA binding site [nucleotide binding] 649639008295 sequence specific DNA binding site [nucleotide binding]; other site 649639008296 putative cAMP binding site [chemical binding]; other site 649639008297 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 649639008298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639008299 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 649639008300 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 649639008301 iron-sulfur cluster [ion binding]; other site 649639008302 [2Fe-2S] cluster binding site [ion binding]; other site 649639008303 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 649639008304 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 649639008305 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 649639008306 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 649639008307 [4Fe-4S] binding site [ion binding]; other site 649639008308 molybdopterin cofactor binding site; other site 649639008309 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 649639008310 molybdopterin cofactor binding site; other site 649639008311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 649639008312 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 649639008313 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649639008314 FeS/SAM binding site; other site 649639008315 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 649639008316 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 649639008317 MoaE interaction surface [polypeptide binding]; other site 649639008318 MoeB interaction surface [polypeptide binding]; other site 649639008319 thiocarboxylated glycine; other site 649639008320 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 649639008321 MoaE homodimer interface [polypeptide binding]; other site 649639008322 MoaD interaction [polypeptide binding]; other site 649639008323 active site residues [active] 649639008324 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 649639008325 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 649639008326 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 649639008327 dimer interface [polypeptide binding]; other site 649639008328 putative functional site; other site 649639008329 putative MPT binding site; other site 649639008330 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 649639008331 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 649639008332 Cu(I) binding site [ion binding]; other site 649639008333 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 649639008334 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 649639008335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639008336 active site 649639008337 motif I; other site 649639008338 motif II; other site 649639008339 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639008340 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639008341 Coenzyme A binding pocket [chemical binding]; other site 649639008342 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 649639008343 AzlC protein; Region: AzlC; pfam03591 649639008344 Hemerythrin-like domain; Region: Hr-like; cd12108 649639008345 Fe binding site [ion binding]; other site 649639008346 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 649639008347 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 649639008348 SNF2 Helicase protein; Region: DUF3670; pfam12419 649639008349 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 649639008350 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649639008351 ATP binding site [chemical binding]; other site 649639008352 putative Mg++ binding site [ion binding]; other site 649639008353 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649639008354 nucleotide binding region [chemical binding]; other site 649639008355 ATP-binding site [chemical binding]; other site 649639008356 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 649639008357 Uncharacterized conserved protein [Function unknown]; Region: COG1284 649639008358 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 649639008359 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 649639008360 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 649639008361 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 649639008362 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649639008363 dimer interface [polypeptide binding]; other site 649639008364 putative CheW interface [polypeptide binding]; other site 649639008365 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745 649639008366 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 649639008367 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 649639008368 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 649639008369 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 649639008370 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 649639008371 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649639008372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639008373 dimer interface [polypeptide binding]; other site 649639008374 conserved gate region; other site 649639008375 putative PBP binding loops; other site 649639008376 ABC-ATPase subunit interface; other site 649639008377 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 649639008378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639008379 dimer interface [polypeptide binding]; other site 649639008380 conserved gate region; other site 649639008381 putative PBP binding loops; other site 649639008382 ABC-ATPase subunit interface; other site 649639008383 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649639008384 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 649639008385 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 649639008386 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649639008387 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 649639008388 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649639008389 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 649639008390 active site residue [active] 649639008391 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 649639008392 Domain of unknown function DUF20; Region: UPF0118; pfam01594 649639008393 Cupin domain; Region: Cupin_2; pfam07883 649639008394 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 649639008395 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649639008396 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 649639008397 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 649639008398 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 649639008399 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 649639008400 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 649639008401 DctM-like transporters; Region: DctM; pfam06808 649639008402 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 649639008403 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 649639008404 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 649639008405 putative active site [active] 649639008406 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 649639008407 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 649639008408 inhibitor-cofactor binding pocket; inhibition site 649639008409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639008410 catalytic residue [active] 649639008411 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 649639008412 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649639008413 FeS/SAM binding site; other site 649639008414 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 649639008415 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 649639008416 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649639008417 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 649639008418 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 649639008419 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 649639008420 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649639008421 FeS/SAM binding site; other site 649639008422 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 649639008423 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 649639008424 EamA-like transporter family; Region: EamA; pfam00892 649639008425 EamA-like transporter family; Region: EamA; pfam00892 649639008426 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 649639008427 active site 649639008428 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 649639008429 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 649639008430 putative substrate binding pocket [chemical binding]; other site 649639008431 AC domain interface; other site 649639008432 catalytic triad [active] 649639008433 AB domain interface; other site 649639008434 interchain disulfide; other site 649639008435 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 649639008436 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 649639008437 YvrJ protein family; Region: YvrJ; pfam12841 649639008438 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 649639008439 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 649639008440 ligand binding site [chemical binding]; other site 649639008441 flexible hinge region; other site 649639008442 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 649639008443 putative switch regulator; other site 649639008444 non-specific DNA interactions [nucleotide binding]; other site 649639008445 DNA binding site [nucleotide binding] 649639008446 sequence specific DNA binding site [nucleotide binding]; other site 649639008447 putative cAMP binding site [chemical binding]; other site 649639008448 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649639008449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649639008450 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 649639008451 Methyltransferase domain; Region: Methyltransf_31; pfam13847 649639008452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639008453 S-adenosylmethionine binding site [chemical binding]; other site 649639008454 isoaspartyl dipeptidase; Provisional; Region: PRK10657 649639008455 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649639008456 active site 649639008457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639008458 dimer interface [polypeptide binding]; other site 649639008459 phosphorylation site [posttranslational modification] 649639008460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639008461 ATP binding site [chemical binding]; other site 649639008462 Mg2+ binding site [ion binding]; other site 649639008463 G-X-G motif; other site 649639008464 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 649639008465 catalytic residues [active] 649639008466 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 649639008467 PAS domain; Region: PAS_9; pfam13426 649639008468 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649639008469 putative active site [active] 649639008470 heme pocket [chemical binding]; other site 649639008471 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649639008472 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649639008473 metal binding site [ion binding]; metal-binding site 649639008474 active site 649639008475 I-site; other site 649639008476 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649639008477 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 649639008478 KTSC domain; Region: KTSC; pfam13619 649639008479 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649639008480 metal binding site [ion binding]; metal-binding site 649639008481 active site 649639008482 I-site; other site 649639008483 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649639008484 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 649639008485 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 649639008486 motif I; other site 649639008487 active site 649639008488 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639008489 motif II; other site 649639008490 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 649639008491 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 649639008492 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 649639008493 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 649639008494 Walker A/P-loop; other site 649639008495 ATP binding site [chemical binding]; other site 649639008496 Q-loop/lid; other site 649639008497 ABC transporter signature motif; other site 649639008498 Walker B; other site 649639008499 D-loop; other site 649639008500 H-loop/switch region; other site 649639008501 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 649639008502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 649639008503 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 649639008504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639008505 dimer interface [polypeptide binding]; other site 649639008506 conserved gate region; other site 649639008507 ABC-ATPase subunit interface; other site 649639008508 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 649639008509 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 649639008510 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649639008511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639008512 active site 649639008513 phosphorylation site [posttranslational modification] 649639008514 intermolecular recognition site; other site 649639008515 dimerization interface [polypeptide binding]; other site 649639008516 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649639008517 DNA binding site [nucleotide binding] 649639008518 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 649639008519 PhoU domain; Region: PhoU; pfam01895 649639008520 PhoU domain; Region: PhoU; pfam01895 649639008521 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 649639008522 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 649639008523 Walker A/P-loop; other site 649639008524 ATP binding site [chemical binding]; other site 649639008525 Q-loop/lid; other site 649639008526 ABC transporter signature motif; other site 649639008527 Walker B; other site 649639008528 D-loop; other site 649639008529 H-loop/switch region; other site 649639008530 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 649639008531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639008532 dimer interface [polypeptide binding]; other site 649639008533 conserved gate region; other site 649639008534 ABC-ATPase subunit interface; other site 649639008535 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 649639008536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639008537 dimer interface [polypeptide binding]; other site 649639008538 conserved gate region; other site 649639008539 putative PBP binding loops; other site 649639008540 ABC-ATPase subunit interface; other site 649639008541 PBP superfamily domain; Region: PBP_like_2; cl17296 649639008542 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 649639008543 hypothetical protein; Provisional; Region: PRK14553 649639008544 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 649639008545 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 649639008546 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 649639008547 homodimer interface [polypeptide binding]; other site 649639008548 oligonucleotide binding site [chemical binding]; other site 649639008549 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 649639008550 Peptidase family M50; Region: Peptidase_M50; pfam02163 649639008551 active site 649639008552 putative substrate binding region [chemical binding]; other site 649639008553 Peptidase family M23; Region: Peptidase_M23; pfam01551 649639008554 Predicted membrane protein [Function unknown]; Region: COG2259 649639008555 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 649639008556 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 649639008557 Switch I; other site 649639008558 Switch II; other site 649639008559 septum formation inhibitor; Reviewed; Region: minC; PRK00513 649639008560 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 649639008561 rod shape-determining protein MreD; Region: MreD; cl01087 649639008562 rod shape-determining protein MreC; Provisional; Region: PRK13922 649639008563 rod shape-determining protein MreC; Region: MreC; pfam04085 649639008564 rod shape-determining protein MreB; Provisional; Region: PRK13927 649639008565 MreB and similar proteins; Region: MreB_like; cd10225 649639008566 nucleotide binding site [chemical binding]; other site 649639008567 Mg binding site [ion binding]; other site 649639008568 putative protofilament interaction site [polypeptide binding]; other site 649639008569 RodZ interaction site [polypeptide binding]; other site 649639008570 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 649639008571 active site 649639008572 DNA binding site [nucleotide binding] 649639008573 Int/Topo IB signature motif; other site 649639008574 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 649639008575 active site 649639008576 catalytic residues [active] 649639008577 DNA binding site [nucleotide binding] 649639008578 Int/Topo IB signature motif; other site 649639008579 ribonuclease Y; Region: RNase_Y; TIGR03319 649639008580 Part of AAA domain; Region: AAA_19; pfam13245 649639008581 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 649639008582 Family description; Region: UvrD_C_2; pfam13538 649639008583 AAA ATPase domain; Region: AAA_15; pfam13175 649639008584 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639008585 Walker A/P-loop; other site 649639008586 ATP binding site [chemical binding]; other site 649639008587 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 649639008588 putative active site [active] 649639008589 putative metal-binding site [ion binding]; other site 649639008590 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 649639008591 putative nucleic acid binding site [nucleotide binding]; other site 649639008592 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 649639008593 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 649639008594 active site 649639008595 dimer interface [polypeptide binding]; other site 649639008596 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 649639008597 Ligand Binding Site [chemical binding]; other site 649639008598 Molecular Tunnel; other site 649639008599 Protein of unknown function (DUF3487); Region: DUF3487; cl13432 649639008600 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 649639008601 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 649639008602 Penicillinase repressor; Region: Pencillinase_R; pfam03965 649639008603 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 649639008604 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 649639008605 metal-binding site [ion binding] 649639008606 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 649639008607 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639008608 motif II; other site 649639008609 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 649639008610 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 649639008611 metal-binding site [ion binding] 649639008612 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 649639008613 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 649639008614 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 649639008615 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 649639008616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639008617 dimer interface [polypeptide binding]; other site 649639008618 phosphorylation site [posttranslational modification] 649639008619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639008620 ATP binding site [chemical binding]; other site 649639008621 Mg2+ binding site [ion binding]; other site 649639008622 G-X-G motif; other site 649639008623 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649639008624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639008625 active site 649639008626 phosphorylation site [posttranslational modification] 649639008627 intermolecular recognition site; other site 649639008628 dimerization interface [polypeptide binding]; other site 649639008629 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649639008630 DNA binding site [nucleotide binding] 649639008631 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 649639008632 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649639008633 dimerization interface [polypeptide binding]; other site 649639008634 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639008635 dimer interface [polypeptide binding]; other site 649639008636 phosphorylation site [posttranslational modification] 649639008637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639008638 ATP binding site [chemical binding]; other site 649639008639 Mg2+ binding site [ion binding]; other site 649639008640 G-X-G motif; other site 649639008641 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649639008642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639008643 active site 649639008644 phosphorylation site [posttranslational modification] 649639008645 intermolecular recognition site; other site 649639008646 dimerization interface [polypeptide binding]; other site 649639008647 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649639008648 DNA binding site [nucleotide binding] 649639008649 VPS10 domain; Region: VPS10; smart00602 649639008650 Uncharacterized conserved protein [Function unknown]; Region: COG0398 649639008651 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 649639008652 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 649639008653 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 649639008654 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 649639008655 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 649639008656 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 649639008657 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 649639008658 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 649639008659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 649639008660 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 649639008661 Peptidase family M23; Region: Peptidase_M23; pfam01551 649639008662 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639008663 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 649639008664 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639008665 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639008666 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 649639008667 NlpC/P60 family; Region: NLPC_P60; pfam00877 649639008668 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 649639008669 TIR domain; Region: TIR_2; pfam13676 649639008670 AAA domain; Region: AAA_22; pfam13401 649639008671 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 649639008672 Integrase core domain; Region: rve; pfam00665 649639008673 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 649639008674 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 649639008675 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 649639008676 cadmium resistance transporter (or sequestration) family protein; Region: cad; TIGR00779 649639008677 Cadmium resistance transporter; Region: Cad; pfam03596 649639008678 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 649639008679 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 649639008680 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649639008681 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 649639008682 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 649639008683 metal-binding site [ion binding] 649639008684 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 649639008685 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 649639008686 metal-binding site [ion binding] 649639008687 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 649639008688 Soluble P-type ATPase [General function prediction only]; Region: COG4087 649639008689 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649639008690 dimerization interface [polypeptide binding]; other site 649639008691 putative DNA binding site [nucleotide binding]; other site 649639008692 putative Zn2+ binding site [ion binding]; other site 649639008693 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 649639008694 metal-binding site [ion binding] 649639008695 mercuric reductase; Region: MerA; TIGR02053 649639008696 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649639008697 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 649639008698 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 649639008699 DNA binding residues [nucleotide binding] 649639008700 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 649639008701 dimer interface [polypeptide binding]; other site 649639008702 mercury binding site [ion binding]; other site 649639008703 hypothetical protein; Reviewed; Region: PRK00024 649639008704 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 649639008705 helix-hairpin-helix signature motif; other site 649639008706 active site 649639008707 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 649639008708 Maf-like protein; Region: Maf; pfam02545 649639008709 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 649639008710 active site 649639008711 dimer interface [polypeptide binding]; other site 649639008712 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 649639008713 Aspartase; Region: Aspartase; cd01357 649639008714 active sites [active] 649639008715 tetramer interface [polypeptide binding]; other site 649639008716 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 649639008717 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 649639008718 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 649639008719 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 649639008720 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 649639008721 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 649639008722 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 649639008723 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 649639008724 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 649639008725 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 649639008726 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 649639008727 Protein of unknown function (DUF1258); Region: DUF1258; pfam06869 649639008728 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 649639008729 Walker A motif; other site 649639008730 ATP binding site [chemical binding]; other site 649639008731 Walker B motif; other site 649639008732 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 649639008733 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 649639008734 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 649639008735 Walker A motif; other site 649639008736 ATP binding site [chemical binding]; other site 649639008737 Walker B motif; other site 649639008738 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 649639008739 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 649639008740 GAF domain; Region: GAF_3; pfam13492 649639008741 GAF domain; Region: GAF_2; pfam13185 649639008742 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649639008743 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649639008744 metal binding site [ion binding]; metal-binding site 649639008745 active site 649639008746 I-site; other site 649639008747 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 649639008748 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 649639008749 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 649639008750 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 649639008751 ATP-grasp domain; Region: ATP-grasp_4; cl17255 649639008752 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 649639008753 ATP-grasp domain; Region: ATP-grasp_4; cl17255 649639008754 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649639008755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639008756 active site 649639008757 phosphorylation site [posttranslational modification] 649639008758 intermolecular recognition site; other site 649639008759 dimerization interface [polypeptide binding]; other site 649639008760 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649639008761 DNA binding residues [nucleotide binding] 649639008762 dimerization interface [polypeptide binding]; other site 649639008763 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649639008764 Histidine kinase; Region: HisKA_3; pfam07730 649639008765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639008766 ATP binding site [chemical binding]; other site 649639008767 Mg2+ binding site [ion binding]; other site 649639008768 G-X-G motif; other site 649639008769 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 649639008770 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 649639008771 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 649639008772 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 649639008773 homodimer interface [polypeptide binding]; other site 649639008774 substrate-cofactor binding pocket; other site 649639008775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639008776 catalytic residue [active] 649639008777 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 649639008778 homodimer interface [polypeptide binding]; other site 649639008779 homotetramer interface [polypeptide binding]; other site 649639008780 active site pocket [active] 649639008781 cleavage site 649639008782 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 649639008783 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 649639008784 active site 649639008785 HIGH motif; other site 649639008786 nucleotide binding site [chemical binding]; other site 649639008787 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 649639008788 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 649639008789 active site 649639008790 KMSKS motif; other site 649639008791 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 649639008792 tRNA binding surface [nucleotide binding]; other site 649639008793 anticodon binding site; other site 649639008794 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 649639008795 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 649639008796 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 649639008797 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 649639008798 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639008799 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 649639008800 Sodium Bile acid symporter family; Region: SBF; pfam01758 649639008801 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 649639008802 Transposase; Region: DDE_Tnp_ISL3; pfam01610 649639008803 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 649639008804 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 649639008805 inhibitor-cofactor binding pocket; inhibition site 649639008806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639008807 catalytic residue [active] 649639008808 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 649639008809 dimer interface [polypeptide binding]; other site 649639008810 active site 649639008811 Schiff base residues; other site 649639008812 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 649639008813 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 649639008814 active site 649639008815 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 649639008816 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 649639008817 domain interfaces; other site 649639008818 active site 649639008819 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 649639008820 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 649639008821 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 649639008822 tRNA; other site 649639008823 putative tRNA binding site [nucleotide binding]; other site 649639008824 putative NADP binding site [chemical binding]; other site 649639008825 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 649639008826 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 649639008827 G1 box; other site 649639008828 GTP/Mg2+ binding site [chemical binding]; other site 649639008829 Switch I region; other site 649639008830 G2 box; other site 649639008831 G3 box; other site 649639008832 Switch II region; other site 649639008833 G4 box; other site 649639008834 G5 box; other site 649639008835 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 649639008836 Found in ATP-dependent protease La (LON); Region: LON; smart00464 649639008837 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639008838 Walker A motif; other site 649639008839 ATP binding site [chemical binding]; other site 649639008840 Walker B motif; other site 649639008841 arginine finger; other site 649639008842 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 649639008843 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 649639008844 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639008845 Walker A motif; other site 649639008846 ATP binding site [chemical binding]; other site 649639008847 Walker B motif; other site 649639008848 arginine finger; other site 649639008849 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 649639008850 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649639008851 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 649639008852 active site 649639008853 metal binding site [ion binding]; metal-binding site 649639008854 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 649639008855 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 649639008856 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 649639008857 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639008858 Walker A motif; other site 649639008859 ATP binding site [chemical binding]; other site 649639008860 Walker B motif; other site 649639008861 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 649639008862 trigger factor; Provisional; Region: tig; PRK01490 649639008863 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 649639008864 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 649639008865 TPR repeat; Region: TPR_11; pfam13414 649639008866 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649639008867 binding surface 649639008868 TPR motif; other site 649639008869 stage II sporulation protein P; Region: spore_II_P; TIGR02867 649639008870 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 649639008871 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639008872 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649639008873 DNA binding residues [nucleotide binding] 649639008874 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 649639008875 active site 649639008876 metal binding site [ion binding]; metal-binding site 649639008877 homotetramer interface [polypeptide binding]; other site 649639008878 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 649639008879 active site 649639008880 dimerization interface [polypeptide binding]; other site 649639008881 ribonuclease PH; Reviewed; Region: rph; PRK00173 649639008882 Ribonuclease PH; Region: RNase_PH_bact; cd11362 649639008883 hexamer interface [polypeptide binding]; other site 649639008884 active site 649639008885 Sporulation and spore germination; Region: Germane; pfam10646 649639008886 Spore germination protein [General function prediction only]; Region: COG5401 649639008887 Sporulation and spore germination; Region: Germane; pfam10646 649639008888 glutamate racemase; Provisional; Region: PRK00865 649639008889 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649639008890 MarR family; Region: MarR; pfam01047 649639008891 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 649639008892 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 649639008893 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 649639008894 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 649639008895 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 649639008896 dimerization domain swap beta strand [polypeptide binding]; other site 649639008897 regulatory protein interface [polypeptide binding]; other site 649639008898 active site 649639008899 regulatory phosphorylation site [posttranslational modification]; other site 649639008900 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649639008901 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649639008902 DNA binding residues [nucleotide binding] 649639008903 dimerization interface [polypeptide binding]; other site 649639008904 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 649639008905 active site 649639008906 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 649639008907 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 649639008908 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 649639008909 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 649639008910 L-aspartate oxidase; Provisional; Region: PRK06175 649639008911 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 649639008912 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 649639008913 putative Iron-sulfur protein interface [polypeptide binding]; other site 649639008914 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 649639008915 proximal heme binding site [chemical binding]; other site 649639008916 distal heme binding site [chemical binding]; other site 649639008917 putative dimer interface [polypeptide binding]; other site 649639008918 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 649639008919 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 649639008920 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 649639008921 aspartate kinase; Reviewed; Region: PRK06635 649639008922 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 649639008923 putative catalytic residues [active] 649639008924 putative nucleotide binding site [chemical binding]; other site 649639008925 putative aspartate binding site [chemical binding]; other site 649639008926 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 649639008927 putative allosteric regulatory site; other site 649639008928 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 649639008929 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 649639008930 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 649639008931 GIY-YIG motif/motif A; other site 649639008932 active site 649639008933 catalytic site [active] 649639008934 putative DNA binding site [nucleotide binding]; other site 649639008935 metal binding site [ion binding]; metal-binding site 649639008936 UvrB/uvrC motif; Region: UVR; pfam02151 649639008937 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 649639008938 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 649639008939 DNA binding site [nucleotide binding] 649639008940 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 649639008941 catalytic residues [active] 649639008942 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 649639008943 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 649639008944 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 649639008945 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 649639008946 Ligand binding site [chemical binding]; other site 649639008947 Electron transfer flavoprotein domain; Region: ETF; pfam01012 649639008948 enoyl-CoA hydratase; Provisional; Region: PRK07658 649639008949 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 649639008950 substrate binding site [chemical binding]; other site 649639008951 oxyanion hole (OAH) forming residues; other site 649639008952 trimer interface [polypeptide binding]; other site 649639008953 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649639008954 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649639008955 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 649639008956 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 649639008957 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 649639008958 acyl-activating enzyme (AAE) consensus motif; other site 649639008959 putative AMP binding site [chemical binding]; other site 649639008960 putative active site [active] 649639008961 putative CoA binding site [chemical binding]; other site 649639008962 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 649639008963 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649639008964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639008965 dimer interface [polypeptide binding]; other site 649639008966 conserved gate region; other site 649639008967 putative PBP binding loops; other site 649639008968 ABC-ATPase subunit interface; other site 649639008969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639008970 dimer interface [polypeptide binding]; other site 649639008971 conserved gate region; other site 649639008972 putative PBP binding loops; other site 649639008973 ABC-ATPase subunit interface; other site 649639008974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639008975 Response regulator receiver domain; Region: Response_reg; pfam00072 649639008976 active site 649639008977 phosphorylation site [posttranslational modification] 649639008978 intermolecular recognition site; other site 649639008979 dimerization interface [polypeptide binding]; other site 649639008980 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 649639008981 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649639008982 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649639008983 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 649639008984 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649639008985 dimerization interface [polypeptide binding]; other site 649639008986 Histidine kinase; Region: His_kinase; pfam06580 649639008987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639008988 ATP binding site [chemical binding]; other site 649639008989 Mg2+ binding site [ion binding]; other site 649639008990 G-X-G motif; other site 649639008991 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649639008992 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649639008993 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 649639008994 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 649639008995 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 649639008996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 649639008997 Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995 649639008998 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 649639008999 Predicted membrane protein [Function unknown]; Region: COG3766 649639009000 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 649639009001 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 649639009002 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 649639009003 MutS domain III; Region: MutS_III; pfam05192 649639009004 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 649639009005 Walker A/P-loop; other site 649639009006 ATP binding site [chemical binding]; other site 649639009007 Q-loop/lid; other site 649639009008 ABC transporter signature motif; other site 649639009009 Walker B; other site 649639009010 D-loop; other site 649639009011 H-loop/switch region; other site 649639009012 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 649639009013 Smr domain; Region: Smr; pfam01713 649639009014 hypothetical protein; Provisional; Region: PRK08609 649639009015 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 649639009016 active site 649639009017 primer binding site [nucleotide binding]; other site 649639009018 NTP binding site [chemical binding]; other site 649639009019 metal binding triad [ion binding]; metal-binding site 649639009020 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 649639009021 active site 649639009022 Colicin V production protein; Region: Colicin_V; pfam02674 649639009023 Cell division protein ZapA; Region: ZapA; cl01146 649639009024 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 649639009025 ribonuclease HIII; Provisional; Region: PRK00996 649639009026 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 649639009027 RNA/DNA hybrid binding site [nucleotide binding]; other site 649639009028 active site 649639009029 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 649639009030 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 649639009031 active site 649639009032 metal binding site [ion binding]; metal-binding site 649639009033 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 649639009034 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 649639009035 putative tRNA-binding site [nucleotide binding]; other site 649639009036 B3/4 domain; Region: B3_4; pfam03483 649639009037 tRNA synthetase B5 domain; Region: B5; smart00874 649639009038 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 649639009039 dimer interface [polypeptide binding]; other site 649639009040 motif 1; other site 649639009041 motif 3; other site 649639009042 motif 2; other site 649639009043 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 649639009044 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 649639009045 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 649639009046 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 649639009047 dimer interface [polypeptide binding]; other site 649639009048 motif 1; other site 649639009049 active site 649639009050 motif 2; other site 649639009051 motif 3; other site 649639009052 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 649639009053 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 649639009054 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 649639009055 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 649639009056 BCCT family transporter; Region: BCCT; pfam02028 649639009057 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 649639009058 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 649639009059 oligomer interface [polypeptide binding]; other site 649639009060 active site 649639009061 metal binding site [ion binding]; metal-binding site 649639009062 dUTPase; Region: dUTPase_2; pfam08761 649639009063 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 649639009064 active site 649639009065 homodimer interface [polypeptide binding]; other site 649639009066 metal binding site [ion binding]; metal-binding site 649639009067 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 649639009068 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 649639009069 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 649639009070 putative DNA binding site [nucleotide binding]; other site 649639009071 putative homodimer interface [polypeptide binding]; other site 649639009072 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 649639009073 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 649639009074 active site 649639009075 DNA binding site [nucleotide binding] 649639009076 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 649639009077 DNA binding site [nucleotide binding] 649639009078 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 649639009079 DNA binding site [nucleotide binding] 649639009080 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 649639009081 nucleotide binding site [chemical binding]; other site 649639009082 Uncharacterized conserved protein [Function unknown]; Region: COG0398 649639009083 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 649639009084 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 649639009085 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 649639009086 23S rRNA binding site [nucleotide binding]; other site 649639009087 L21 binding site [polypeptide binding]; other site 649639009088 L13 binding site [polypeptide binding]; other site 649639009089 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 649639009090 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 649639009091 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 649639009092 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 649639009093 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649639009094 PAS domain; Region: PAS_9; pfam13426 649639009095 putative active site [active] 649639009096 heme pocket [chemical binding]; other site 649639009097 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649639009098 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649639009099 metal binding site [ion binding]; metal-binding site 649639009100 active site 649639009101 I-site; other site 649639009102 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649639009103 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 649639009104 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 649639009105 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 649639009106 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 649639009107 active site 649639009108 dimer interface [polypeptide binding]; other site 649639009109 motif 1; other site 649639009110 motif 2; other site 649639009111 motif 3; other site 649639009112 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 649639009113 anticodon binding site; other site 649639009114 YtxC-like family; Region: YtxC; cl08500 649639009115 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 649639009116 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649639009117 FeS/SAM binding site; other site 649639009118 primosomal protein DnaI; Reviewed; Region: PRK08939 649639009119 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 649639009120 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639009121 Walker A motif; other site 649639009122 ATP binding site [chemical binding]; other site 649639009123 Walker B motif; other site 649639009124 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 649639009125 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 649639009126 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 649639009127 ATP cone domain; Region: ATP-cone; pfam03477 649639009128 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 649639009129 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 649639009130 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 649639009131 CoA-binding site [chemical binding]; other site 649639009132 ATP-binding [chemical binding]; other site 649639009133 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 649639009134 Domain of unknown function DUF; Region: DUF204; pfam02659 649639009135 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 649639009136 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 649639009137 DNA binding site [nucleotide binding] 649639009138 catalytic residue [active] 649639009139 H2TH interface [polypeptide binding]; other site 649639009140 putative catalytic residues [active] 649639009141 turnover-facilitating residue; other site 649639009142 intercalation triad [nucleotide binding]; other site 649639009143 8OG recognition residue [nucleotide binding]; other site 649639009144 putative reading head residues; other site 649639009145 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 649639009146 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 649639009147 DNA polymerase I; Provisional; Region: PRK05755 649639009148 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 649639009149 active site 649639009150 metal binding site 1 [ion binding]; metal-binding site 649639009151 putative 5' ssDNA interaction site; other site 649639009152 metal binding site 3; metal-binding site 649639009153 metal binding site 2 [ion binding]; metal-binding site 649639009154 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 649639009155 putative DNA binding site [nucleotide binding]; other site 649639009156 putative metal binding site [ion binding]; other site 649639009157 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 649639009158 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 649639009159 active site 649639009160 DNA binding site [nucleotide binding] 649639009161 catalytic site [active] 649639009162 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649639009163 dimerization interface [polypeptide binding]; other site 649639009164 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 649639009165 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649639009166 putative active site [active] 649639009167 heme pocket [chemical binding]; other site 649639009168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639009169 dimer interface [polypeptide binding]; other site 649639009170 phosphorylation site [posttranslational modification] 649639009171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639009172 ATP binding site [chemical binding]; other site 649639009173 Mg2+ binding site [ion binding]; other site 649639009174 G-X-G motif; other site 649639009175 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649639009176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639009177 active site 649639009178 phosphorylation site [posttranslational modification] 649639009179 intermolecular recognition site; other site 649639009180 dimerization interface [polypeptide binding]; other site 649639009181 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649639009182 DNA binding site [nucleotide binding] 649639009183 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 649639009184 active site 2 [active] 649639009185 active site 1 [active] 649639009186 malate dehydrogenase; Reviewed; Region: PRK06223 649639009187 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 649639009188 dimer interface [polypeptide binding]; other site 649639009189 NAD(P) binding site [chemical binding]; other site 649639009190 tetramer (dimer of dimers) interface [polypeptide binding]; other site 649639009191 substrate binding site [chemical binding]; other site 649639009192 isocitrate dehydrogenase; Reviewed; Region: PRK07006 649639009193 isocitrate dehydrogenase; Validated; Region: PRK07362 649639009194 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 649639009195 dimer interface [polypeptide binding]; other site 649639009196 active site 649639009197 citrylCoA binding site [chemical binding]; other site 649639009198 Citrate synthase; Region: Citrate_synt; pfam00285 649639009199 oxalacetate/citrate binding site [chemical binding]; other site 649639009200 coenzyme A binding site [chemical binding]; other site 649639009201 catalytic triad [active] 649639009202 Protein of unknown function (DUF441); Region: DUF441; pfam04284 649639009203 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 649639009204 Domain of unknown function DUF20; Region: UPF0118; pfam01594 649639009205 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 649639009206 pyruvate kinase; Provisional; Region: PRK06354 649639009207 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 649639009208 domain interfaces; other site 649639009209 active site 649639009210 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 649639009211 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 649639009212 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 649639009213 active site 649639009214 ADP/pyrophosphate binding site [chemical binding]; other site 649639009215 dimerization interface [polypeptide binding]; other site 649639009216 allosteric effector site; other site 649639009217 fructose-1,6-bisphosphate binding site; other site 649639009218 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 649639009219 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 649639009220 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 649639009221 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 649639009222 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 649639009223 YCII-related domain; Region: YCII; cl00999 649639009224 Transcriptional regulators [Transcription]; Region: FadR; COG2186 649639009225 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649639009226 DNA-binding site [nucleotide binding]; DNA binding site 649639009227 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 649639009228 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 649639009229 Malic enzyme, N-terminal domain; Region: malic; pfam00390 649639009230 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 649639009231 putative NAD(P) binding site [chemical binding]; other site 649639009232 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 649639009233 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 649639009234 active site 649639009235 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 649639009236 generic binding surface II; other site 649639009237 generic binding surface I; other site 649639009238 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 649639009239 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 649639009240 DHH family; Region: DHH; pfam01368 649639009241 DHHA1 domain; Region: DHHA1; pfam02272 649639009242 YtpI-like protein; Region: YtpI; pfam14007 649639009243 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 649639009244 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649639009245 DNA-binding site [nucleotide binding]; DNA binding site 649639009246 DRTGG domain; Region: DRTGG; pfam07085 649639009247 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 649639009248 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 649639009249 active site 2 [active] 649639009250 active site 1 [active] 649639009251 metal-dependent hydrolase; Provisional; Region: PRK00685 649639009252 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 649639009253 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 649639009254 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 649639009255 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 649639009256 active site 649639009257 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 649639009258 classical (c) SDRs; Region: SDR_c; cd05233 649639009259 NAD(P) binding site [chemical binding]; other site 649639009260 active site 649639009261 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649639009262 Ligand Binding Site [chemical binding]; other site 649639009263 EcsC protein family; Region: EcsC; pfam12787 649639009264 propionate/acetate kinase; Provisional; Region: PRK12379 649639009265 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 649639009266 nucleotide binding site [chemical binding]; other site 649639009267 butyrate kinase; Provisional; Region: PRK03011 649639009268 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 649639009269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639009270 S-adenosylmethionine binding site [chemical binding]; other site 649639009271 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 649639009272 dimer interface [polypeptide binding]; other site 649639009273 catalytic triad [active] 649639009274 peroxidatic and resolving cysteines [active] 649639009275 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 649639009276 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 649639009277 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 649639009278 ATP-NAD kinase; Region: NAD_kinase; pfam01513 649639009279 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 649639009280 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 649639009281 active site 649639009282 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 649639009283 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 649639009284 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 649639009285 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 649639009286 Ligand Binding Site [chemical binding]; other site 649639009287 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 649639009288 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 649639009289 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649639009290 catalytic residue [active] 649639009291 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 649639009292 septation ring formation regulator EzrA; Provisional; Region: PRK04778 649639009293 histidinol-phosphatase; Reviewed; Region: PRK08123 649639009294 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 649639009295 active site 649639009296 dimer interface [polypeptide binding]; other site 649639009297 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649639009298 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649639009299 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 649639009300 GAF domain; Region: GAF_2; pfam13185 649639009301 GAF domain; Region: GAF_2; pfam13185 649639009302 GAF domain; Region: GAF; cl17456 649639009303 GAF domain; Region: GAF_3; pfam13492 649639009304 GAF domain; Region: GAF_2; pfam13185 649639009305 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649639009306 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649639009307 metal binding site [ion binding]; metal-binding site 649639009308 active site 649639009309 I-site; other site 649639009310 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 649639009311 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 649639009312 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 649639009313 RNA binding surface [nucleotide binding]; other site 649639009314 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 649639009315 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 649639009316 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 649639009317 active site 649639009318 HIGH motif; other site 649639009319 dimer interface [polypeptide binding]; other site 649639009320 KMSKS motif; other site 649639009321 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 649639009322 RNA binding surface [nucleotide binding]; other site 649639009323 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 649639009324 Transglycosylase; Region: Transgly; pfam00912 649639009325 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 649639009326 FOG: CBS domain [General function prediction only]; Region: COG0517 649639009327 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 649639009328 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 649639009329 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 649639009330 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 649639009331 active site 649639009332 Zn binding site [ion binding]; other site 649639009333 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 649639009334 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 649639009335 flagellar motor protein MotS; Reviewed; Region: PRK06925 649639009336 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 649639009337 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 649639009338 ligand binding site [chemical binding]; other site 649639009339 flagellar motor protein MotP; Reviewed; Region: PRK06926 649639009340 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 649639009341 catabolite control protein A; Region: ccpA; TIGR01481 649639009342 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649639009343 DNA binding site [nucleotide binding] 649639009344 domain linker motif; other site 649639009345 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 649639009346 dimerization interface [polypeptide binding]; other site 649639009347 effector binding site; other site 649639009348 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 649639009349 Chorismate mutase type II; Region: CM_2; cl00693 649639009350 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 649639009351 Cell division protein FtsA; Region: FtsA; smart00842 649639009352 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 649639009353 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 649639009354 nucleotide binding site [chemical binding]; other site 649639009355 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 649639009356 YtxH-like protein; Region: YtxH; pfam12732 649639009357 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 649639009358 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 649639009359 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 649639009360 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 649639009361 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 649639009362 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 649639009363 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 649639009364 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 649639009365 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 649639009366 active site 649639009367 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 649639009368 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 649639009369 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 649639009370 hypothetical protein; Provisional; Region: PRK13668 649639009371 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 649639009372 catalytic residues [active] 649639009373 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 649639009374 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 649639009375 YtoQ family protein; Region: YtoQ_fam; TIGR03646 649639009376 NTPase; Reviewed; Region: PRK03114 649639009377 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 649639009378 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 649639009379 oligomer interface [polypeptide binding]; other site 649639009380 active site 649639009381 metal binding site [ion binding]; metal-binding site 649639009382 Predicted small secreted protein [Function unknown]; Region: COG5584 649639009383 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 649639009384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639009385 S-adenosylmethionine binding site [chemical binding]; other site 649639009386 YtzH-like protein; Region: YtzH; pfam14165 649639009387 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 649639009388 Phosphotransferase enzyme family; Region: APH; pfam01636 649639009389 active site 649639009390 ATP binding site [chemical binding]; other site 649639009391 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 649639009392 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 649639009393 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 649639009394 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 649639009395 dimer interface [polypeptide binding]; other site 649639009396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639009397 catalytic residue [active] 649639009398 dipeptidase PepV; Reviewed; Region: PRK07318 649639009399 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 649639009400 active site 649639009401 metal binding site [ion binding]; metal-binding site 649639009402 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 649639009403 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 649639009404 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 649639009405 RNA binding surface [nucleotide binding]; other site 649639009406 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 649639009407 active site 649639009408 uracil binding [chemical binding]; other site 649639009409 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 649639009410 cell division protein FtsW; Region: ftsW; TIGR02614 649639009411 Predicted transcriptional regulators [Transcription]; Region: COG1733 649639009412 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649639009413 dimerization interface [polypeptide binding]; other site 649639009414 putative DNA binding site [nucleotide binding]; other site 649639009415 putative Zn2+ binding site [ion binding]; other site 649639009416 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 649639009417 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 649639009418 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 649639009419 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 649639009420 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 649639009421 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 649639009422 HI0933-like protein; Region: HI0933_like; pfam03486 649639009423 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 649639009424 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 649639009425 HIGH motif; other site 649639009426 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 649639009427 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 649639009428 active site 649639009429 KMSKS motif; other site 649639009430 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 649639009431 tRNA binding surface [nucleotide binding]; other site 649639009432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639009433 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649639009434 putative substrate translocation pore; other site 649639009435 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 649639009436 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 649639009437 tetramer interface [polypeptide binding]; other site 649639009438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639009439 catalytic residue [active] 649639009440 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 649639009441 Methyltransferase domain; Region: Methyltransf_31; pfam13847 649639009442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639009443 S-adenosylmethionine binding site [chemical binding]; other site 649639009444 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 649639009445 active site 649639009446 ATP binding site [chemical binding]; other site 649639009447 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 649639009448 substrate binding site [chemical binding]; other site 649639009449 activation loop (A-loop); other site 649639009450 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 649639009451 Plasmodium subtelomeric family (PST-A); Region: PST-A; TIGR01607 649639009452 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 649639009453 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 649639009454 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 649639009455 trimer interface [polypeptide binding]; other site 649639009456 putative metal binding site [ion binding]; other site 649639009457 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 649639009458 active site 649639009459 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 649639009460 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649639009461 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 649639009462 S-adenosylmethionine synthetase; Validated; Region: PRK05250 649639009463 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 649639009464 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 649639009465 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 649639009466 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 649639009467 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 649639009468 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 649639009469 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 649639009470 Walker A/P-loop; other site 649639009471 ATP binding site [chemical binding]; other site 649639009472 Q-loop/lid; other site 649639009473 ABC transporter signature motif; other site 649639009474 Walker B; other site 649639009475 D-loop; other site 649639009476 H-loop/switch region; other site 649639009477 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 649639009478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639009479 dimer interface [polypeptide binding]; other site 649639009480 conserved gate region; other site 649639009481 putative PBP binding loops; other site 649639009482 ABC-ATPase subunit interface; other site 649639009483 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 649639009484 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 649639009485 nudix motif; other site 649639009486 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 649639009487 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 649639009488 GTP binding site; other site 649639009489 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 649639009490 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 649639009491 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 649639009492 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 649639009493 NodB motif; other site 649639009494 putative active site [active] 649639009495 putative catalytic site [active] 649639009496 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 649639009497 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 649639009498 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 649639009499 putative active site [active] 649639009500 catalytic site [active] 649639009501 putative metal binding site [ion binding]; other site 649639009502 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 649639009503 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 649639009504 ATP-grasp domain; Region: ATP-grasp_4; cl17255 649639009505 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 649639009506 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 649639009507 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 649639009508 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649639009509 TAP-like protein; Region: Abhydrolase_4; pfam08386 649639009510 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 649639009511 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 649639009512 NAD binding site [chemical binding]; other site 649639009513 catalytic Zn binding site [ion binding]; other site 649639009514 structural Zn binding site [ion binding]; other site 649639009515 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 649639009516 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 649639009517 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 649639009518 Ligand Binding Site [chemical binding]; other site 649639009519 5'-3' exonuclease; Region: 53EXOc; smart00475 649639009520 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 649639009521 active site 649639009522 metal binding site 1 [ion binding]; metal-binding site 649639009523 putative 5' ssDNA interaction site; other site 649639009524 metal binding site 3; metal-binding site 649639009525 metal binding site 2 [ion binding]; metal-binding site 649639009526 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 649639009527 putative DNA binding site [nucleotide binding]; other site 649639009528 putative metal binding site [ion binding]; other site 649639009529 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 649639009530 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 649639009531 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 649639009532 substrate binding pocket [chemical binding]; other site 649639009533 dimer interface [polypeptide binding]; other site 649639009534 inhibitor binding site; inhibition site 649639009535 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 649639009536 B12 binding site [chemical binding]; other site 649639009537 cobalt ligand [ion binding]; other site 649639009538 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 649639009539 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 649639009540 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 649639009541 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 649639009542 FAD binding site [chemical binding]; other site 649639009543 cystathionine beta-lyase; Provisional; Region: PRK08064 649639009544 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 649639009545 homodimer interface [polypeptide binding]; other site 649639009546 substrate-cofactor binding pocket; other site 649639009547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639009548 catalytic residue [active] 649639009549 cystathionine gamma-synthase; Reviewed; Region: PRK08247 649639009550 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 649639009551 homodimer interface [polypeptide binding]; other site 649639009552 substrate-cofactor binding pocket; other site 649639009553 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639009554 catalytic residue [active] 649639009555 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 649639009556 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 649639009557 dimer interface [polypeptide binding]; other site 649639009558 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639009559 catalytic residue [active] 649639009560 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 649639009561 active site 649639009562 SAM binding site [chemical binding]; other site 649639009563 homodimer interface [polypeptide binding]; other site 649639009564 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 649639009565 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 649639009566 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 649639009567 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 649639009568 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 649639009569 ligand-binding site [chemical binding]; other site 649639009570 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 649639009571 ATP-sulfurylase; Region: ATPS; cd00517 649639009572 active site 649639009573 HXXH motif; other site 649639009574 flexible loop; other site 649639009575 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 649639009576 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 649639009577 Active Sites [active] 649639009578 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 649639009579 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 649639009580 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 649639009581 NAD(P) binding site [chemical binding]; other site 649639009582 catalytic residues [active] 649639009583 homoserine dehydrogenase; Provisional; Region: PRK06270 649639009584 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 649639009585 NAD(P) binding pocket [chemical binding]; other site 649639009586 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 649639009587 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 649639009588 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 649639009589 metal binding site [ion binding]; metal-binding site 649639009590 dimer interface [polypeptide binding]; other site 649639009591 cystathionine gamma-synthase; Provisional; Region: PRK08249 649639009592 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 649639009593 homodimer interface [polypeptide binding]; other site 649639009594 substrate-cofactor binding pocket; other site 649639009595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639009596 catalytic residue [active] 649639009597 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 649639009598 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 649639009599 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 649639009600 active site 649639009601 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 649639009602 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 649639009603 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 649639009604 active site 649639009605 catalytic triad [active] 649639009606 oxyanion hole [active] 649639009607 Predicted permeases [General function prediction only]; Region: COG0679 649639009608 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 649639009609 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 649639009610 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 649639009611 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649639009612 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649639009613 DNA binding site [nucleotide binding] 649639009614 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 649639009615 Predicted permease [General function prediction only]; Region: COG2985 649639009616 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 649639009617 TrkA-C domain; Region: TrkA_C; pfam02080 649639009618 TrkA-C domain; Region: TrkA_C; pfam02080 649639009619 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 649639009620 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 649639009621 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 649639009622 Carbohydrate binding domain (family 17/28); Region: CBM_17_28; pfam03424 649639009623 Carbohydrate binding domain (family 17/28); Region: CBM_17_28; pfam03424 649639009624 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 649639009625 FlxA-like protein; Region: FlxA; pfam14282 649639009626 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 649639009627 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 649639009628 Carbohydrate binding domain (family 17/28); Region: CBM_17_28; pfam03424 649639009629 Carbohydrate binding domain (family 17/28); Region: CBM_17_28; pfam03424 649639009630 SlyX; Region: SlyX; pfam04102 649639009631 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 649639009632 Ion channel; Region: Ion_trans_2; pfam07885 649639009633 TrkA-N domain; Region: TrkA_N; pfam02254 649639009634 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 649639009635 YugN-like family; Region: YugN; pfam08868 649639009636 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 649639009637 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 649639009638 active site 649639009639 dimer interface [polypeptide binding]; other site 649639009640 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 649639009641 dimer interface [polypeptide binding]; other site 649639009642 active site 649639009643 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 649639009644 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 649639009645 dimer interface [polypeptide binding]; other site 649639009646 active site 649639009647 metal binding site [ion binding]; metal-binding site 649639009648 Uncharacterized conserved protein [Function unknown]; Region: COG2155 649639009649 general stress protein 13; Validated; Region: PRK08059 649639009650 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 649639009651 RNA binding site [nucleotide binding]; other site 649639009652 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 649639009653 Na2 binding site [ion binding]; other site 649639009654 putative substrate binding site 1 [chemical binding]; other site 649639009655 Na binding site 1 [ion binding]; other site 649639009656 putative substrate binding site 2 [chemical binding]; other site 649639009657 hypothetical protein; Validated; Region: PRK07682 649639009658 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 649639009659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639009660 homodimer interface [polypeptide binding]; other site 649639009661 catalytic residue [active] 649639009662 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 649639009663 AsnC family; Region: AsnC_trans_reg; pfam01037 649639009664 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 649639009665 putative oxidoreductase FixC; Provisional; Region: PRK10157 649639009666 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 649639009667 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 649639009668 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 649639009669 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 649639009670 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 649639009671 Ligand binding site [chemical binding]; other site 649639009672 Electron transfer flavoprotein domain; Region: ETF; pfam01012 649639009673 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649639009674 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 649639009675 Walker A/P-loop; other site 649639009676 ATP binding site [chemical binding]; other site 649639009677 Q-loop/lid; other site 649639009678 ABC transporter signature motif; other site 649639009679 Walker B; other site 649639009680 D-loop; other site 649639009681 H-loop/switch region; other site 649639009682 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 649639009683 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 649639009684 reactive center loop; other site 649639009685 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 649639009686 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 649639009687 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 649639009688 Predicted permease [General function prediction only]; Region: COG2056 649639009689 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 649639009690 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 649639009691 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 649639009692 DctM-like transporters; Region: DctM; pfam06808 649639009693 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 649639009694 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 649639009695 Divergent PAP2 family; Region: DUF212; pfam02681 649639009696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 649639009697 Putative membrane protein; Region: YuiB; pfam14068 649639009698 chaperone protein dnaJ-related; Provisional; Region: PLN03165 649639009699 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 649639009700 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649639009701 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 649639009702 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 649639009703 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649639009704 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 649639009705 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 649639009706 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649639009707 FeS/SAM binding site; other site 649639009708 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 649639009709 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 649639009710 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 649639009711 hypothetical protein; Provisional; Region: PRK13669 649639009712 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 649639009713 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649639009714 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 649639009715 NifU-like domain; Region: NifU; cl00484 649639009716 spore coat protein YutH; Region: spore_yutH; TIGR02905 649639009717 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 649639009718 tetramer interfaces [polypeptide binding]; other site 649639009719 binuclear metal-binding site [ion binding]; other site 649639009720 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 649639009721 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639009722 active site 649639009723 motif I; other site 649639009724 motif II; other site 649639009725 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639009726 Predicted transcriptional regulator [Transcription]; Region: COG2345 649639009727 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649639009728 putative DNA binding site [nucleotide binding]; other site 649639009729 putative Zn2+ binding site [ion binding]; other site 649639009730 Uncharacterized conserved protein [Function unknown]; Region: COG2445 649639009731 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 649639009732 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 649639009733 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 649639009734 lipoyl synthase; Provisional; Region: PRK05481 649639009735 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649639009736 FeS/SAM binding site; other site 649639009737 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 649639009738 Peptidase family M23; Region: Peptidase_M23; pfam01551 649639009739 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 649639009740 Na2 binding site [ion binding]; other site 649639009741 putative substrate binding site 1 [chemical binding]; other site 649639009742 Na binding site 1 [ion binding]; other site 649639009743 putative substrate binding site 2 [chemical binding]; other site 649639009744 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 649639009745 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 649639009746 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 649639009747 folate binding site [chemical binding]; other site 649639009748 NADP+ binding site [chemical binding]; other site 649639009749 thymidylate synthase; Reviewed; Region: thyA; PRK01827 649639009750 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 649639009751 dimerization interface [polypeptide binding]; other site 649639009752 active site 649639009753 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 649639009754 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 649639009755 Zn2+ binding site [ion binding]; other site 649639009756 Mg2+ binding site [ion binding]; other site 649639009757 Uncharacterized conserved protein [Function unknown]; Region: COG3377 649639009758 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 649639009759 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 649639009760 active site 649639009761 metal binding site [ion binding]; metal-binding site 649639009762 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 649639009763 hypothetical protein; Provisional; Region: PRK10621 649639009764 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 649639009765 Uncharacterized conserved protein [Function unknown]; Region: COG1801 649639009766 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 649639009767 FeS assembly protein SufB; Region: sufB; TIGR01980 649639009768 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 649639009769 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 649639009770 trimerization site [polypeptide binding]; other site 649639009771 active site 649639009772 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 649639009773 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 649639009774 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649639009775 catalytic residue [active] 649639009776 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 649639009777 FeS assembly protein SufD; Region: sufD; TIGR01981 649639009778 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 649639009779 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 649639009780 Walker A/P-loop; other site 649639009781 ATP binding site [chemical binding]; other site 649639009782 Q-loop/lid; other site 649639009783 ABC transporter signature motif; other site 649639009784 Walker B; other site 649639009785 D-loop; other site 649639009786 H-loop/switch region; other site 649639009787 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 649639009788 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 649639009789 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 649639009790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639009791 ABC-ATPase subunit interface; other site 649639009792 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 649639009793 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 649639009794 Walker A/P-loop; other site 649639009795 ATP binding site [chemical binding]; other site 649639009796 Q-loop/lid; other site 649639009797 ABC transporter signature motif; other site 649639009798 Walker B; other site 649639009799 D-loop; other site 649639009800 H-loop/switch region; other site 649639009801 NIL domain; Region: NIL; pfam09383 649639009802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639009803 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649639009804 putative substrate translocation pore; other site 649639009805 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 649639009806 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 649639009807 lipoyl attachment site [posttranslational modification]; other site 649639009808 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 649639009809 ArsC family; Region: ArsC; pfam03960 649639009810 putative ArsC-like catalytic residues; other site 649639009811 putative TRX-like catalytic residues [active] 649639009812 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 649639009813 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 649639009814 active site 649639009815 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 649639009816 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 649639009817 dimer interface [polypeptide binding]; other site 649639009818 active site 649639009819 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06035 649639009820 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 649639009821 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 649639009822 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 649639009823 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 649639009824 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 649639009825 substrate binding site [chemical binding]; other site 649639009826 oxyanion hole (OAH) forming residues; other site 649639009827 trimer interface [polypeptide binding]; other site 649639009828 Coat F domain; Region: Coat_F; pfam07875 649639009829 Phospholipid methyltransferase; Region: PEMT; cl17370 649639009830 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 649639009831 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 649639009832 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 649639009833 putative active site [active] 649639009834 catalytic triad [active] 649639009835 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 649639009836 putative integrin binding motif; other site 649639009837 PA/protease domain interface [polypeptide binding]; other site 649639009838 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 649639009839 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 649639009840 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 649639009841 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 649639009842 SecY translocase; Region: SecY; pfam00344 649639009843 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 649639009844 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 649639009845 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 649639009846 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 649639009847 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 649639009848 homodimer interface [polypeptide binding]; other site 649639009849 substrate-cofactor binding pocket; other site 649639009850 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639009851 catalytic residue [active] 649639009852 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 649639009853 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 649639009854 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 649639009855 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 649639009856 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 649639009857 Sulfatase; Region: Sulfatase; pfam00884 649639009858 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 649639009859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639009860 dimer interface [polypeptide binding]; other site 649639009861 conserved gate region; other site 649639009862 putative PBP binding loops; other site 649639009863 ABC-ATPase subunit interface; other site 649639009864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639009865 dimer interface [polypeptide binding]; other site 649639009866 conserved gate region; other site 649639009867 putative PBP binding loops; other site 649639009868 ABC-ATPase subunit interface; other site 649639009869 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 649639009870 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 649639009871 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 649639009872 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 649639009873 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 649639009874 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 649639009875 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 649639009876 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 649639009877 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639009878 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 649639009879 DNA binding residues [nucleotide binding] 649639009880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 649639009881 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 649639009882 NlpC/P60 family; Region: NLPC_P60; pfam00877 649639009883 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 649639009884 YibE/F-like protein; Region: YibE_F; pfam07907 649639009885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 649639009886 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 649639009887 Peptidase family M23; Region: Peptidase_M23; pfam01551 649639009888 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 649639009889 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 649639009890 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 649639009891 structural tetrad; other site 649639009892 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 649639009893 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649639009894 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649639009895 dimerization interface [polypeptide binding]; other site 649639009896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639009897 dimer interface [polypeptide binding]; other site 649639009898 phosphorylation site [posttranslational modification] 649639009899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639009900 ATP binding site [chemical binding]; other site 649639009901 Mg2+ binding site [ion binding]; other site 649639009902 G-X-G motif; other site 649639009903 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649639009904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639009905 active site 649639009906 phosphorylation site [posttranslational modification] 649639009907 intermolecular recognition site; other site 649639009908 dimerization interface [polypeptide binding]; other site 649639009909 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649639009910 DNA binding site [nucleotide binding] 649639009911 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 649639009912 active site 649639009913 catalytic site [active] 649639009914 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 649639009915 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 649639009916 metal-binding site [ion binding] 649639009917 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 649639009918 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639009919 motif II; other site 649639009920 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 649639009921 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 649639009922 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 649639009923 TrkA-N domain; Region: TrkA_N; pfam02254 649639009924 TrkA-C domain; Region: TrkA_C; pfam02080 649639009925 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 649639009926 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 649639009927 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 649639009928 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 649639009929 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 649639009930 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 649639009931 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 649639009932 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 649639009933 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 649639009934 MgtE intracellular N domain; Region: MgtE_N; pfam03448 649639009935 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 649639009936 Divalent cation transporter; Region: MgtE; pfam01769 649639009937 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 649639009938 MgtC family; Region: MgtC; pfam02308 649639009939 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 649639009940 MgtE intracellular N domain; Region: MgtE_N; pfam03448 649639009941 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 649639009942 Divalent cation transporter; Region: MgtE; pfam01769 649639009943 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 649639009944 Divalent cation transporter; Region: MgtE; pfam01769 649639009945 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 649639009946 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 649639009947 active site 649639009948 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 649639009949 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 649639009950 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649639009951 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649639009952 dimerization interface [polypeptide binding]; other site 649639009953 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639009954 dimer interface [polypeptide binding]; other site 649639009955 phosphorylation site [posttranslational modification] 649639009956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639009957 ATP binding site [chemical binding]; other site 649639009958 Mg2+ binding site [ion binding]; other site 649639009959 G-X-G motif; other site 649639009960 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649639009961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639009962 active site 649639009963 phosphorylation site [posttranslational modification] 649639009964 intermolecular recognition site; other site 649639009965 dimerization interface [polypeptide binding]; other site 649639009966 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649639009967 DNA binding site [nucleotide binding] 649639009968 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 649639009969 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 649639009970 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 649639009971 metal binding site [ion binding]; metal-binding site 649639009972 ligand binding site [chemical binding]; other site 649639009973 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 649639009974 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649639009975 Interdomain contacts; other site 649639009976 Cytokine receptor motif; other site 649639009977 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649639009978 Interdomain contacts; other site 649639009979 Cytokine receptor motif; other site 649639009980 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 649639009981 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 649639009982 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 649639009983 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649639009984 DNA binding site [nucleotide binding] 649639009985 domain linker motif; other site 649639009986 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649639009987 ligand binding site [chemical binding]; other site 649639009988 dimerization interface [polypeptide binding]; other site 649639009989 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649639009990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639009991 dimer interface [polypeptide binding]; other site 649639009992 conserved gate region; other site 649639009993 putative PBP binding loops; other site 649639009994 ABC-ATPase subunit interface; other site 649639009995 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 649639009996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639009997 dimer interface [polypeptide binding]; other site 649639009998 putative PBP binding loops; other site 649639009999 ABC-ATPase subunit interface; other site 649639010000 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649639010001 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649639010002 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 649639010003 SmpB-tmRNA interface; other site 649639010004 ribonuclease R; Region: RNase_R; TIGR02063 649639010005 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 649639010006 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 649639010007 RNB domain; Region: RNB; pfam00773 649639010008 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 649639010009 RNA binding site [nucleotide binding]; other site 649639010010 Esterase/lipase [General function prediction only]; Region: COG1647 649639010011 Preprotein translocase SecG subunit; Region: SecG; cl09123 649639010012 enolase; Provisional; Region: eno; PRK00077 649639010013 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 649639010014 dimer interface [polypeptide binding]; other site 649639010015 metal binding site [ion binding]; metal-binding site 649639010016 substrate binding pocket [chemical binding]; other site 649639010017 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 649639010018 phosphoglyceromutase; Provisional; Region: PRK05434 649639010019 triosephosphate isomerase; Provisional; Region: PRK14567 649639010020 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 649639010021 substrate binding site [chemical binding]; other site 649639010022 dimer interface [polypeptide binding]; other site 649639010023 catalytic triad [active] 649639010024 Phosphoglycerate kinase; Region: PGK; pfam00162 649639010025 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 649639010026 substrate binding site [chemical binding]; other site 649639010027 hinge regions; other site 649639010028 ADP binding site [chemical binding]; other site 649639010029 catalytic site [active] 649639010030 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 649639010031 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 649639010032 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 649639010033 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 649639010034 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 649639010035 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 649639010036 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 649639010037 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 649639010038 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 649639010039 Clp protease; Region: CLP_protease; pfam00574 649639010040 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 649639010041 oligomer interface [polypeptide binding]; other site 649639010042 active site residues [active] 649639010043 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 649639010044 dimerization domain swap beta strand [polypeptide binding]; other site 649639010045 regulatory protein interface [polypeptide binding]; other site 649639010046 active site 649639010047 regulatory phosphorylation site [posttranslational modification]; other site 649639010048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 649639010049 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 649639010050 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 649639010051 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 649639010052 phosphate binding site [ion binding]; other site 649639010053 putative substrate binding pocket [chemical binding]; other site 649639010054 dimer interface [polypeptide binding]; other site 649639010055 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 649639010056 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 649639010057 putative active site [active] 649639010058 nucleotide binding site [chemical binding]; other site 649639010059 nudix motif; other site 649639010060 putative metal binding site [ion binding]; other site 649639010061 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 649639010062 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 649639010063 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649639010064 TPR repeat; Region: TPR_11; pfam13414 649639010065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649639010066 binding surface 649639010067 TPR motif; other site 649639010068 Tetratricopeptide repeat; Region: TPR_16; pfam13432 649639010069 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 649639010070 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 649639010071 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 649639010072 metal binding site [ion binding]; metal-binding site 649639010073 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 649639010074 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 649639010075 substrate binding site [chemical binding]; other site 649639010076 glutamase interaction surface [polypeptide binding]; other site 649639010077 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 649639010078 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 649639010079 catalytic residues [active] 649639010080 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 649639010081 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 649639010082 putative active site [active] 649639010083 oxyanion strand; other site 649639010084 catalytic triad [active] 649639010085 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 649639010086 putative active site pocket [active] 649639010087 4-fold oligomerization interface [polypeptide binding]; other site 649639010088 metal binding residues [ion binding]; metal-binding site 649639010089 3-fold/trimer interface [polypeptide binding]; other site 649639010090 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 649639010091 histidinol dehydrogenase; Region: hisD; TIGR00069 649639010092 NAD binding site [chemical binding]; other site 649639010093 dimerization interface [polypeptide binding]; other site 649639010094 product binding site; other site 649639010095 substrate binding site [chemical binding]; other site 649639010096 zinc binding site [ion binding]; other site 649639010097 catalytic residues [active] 649639010098 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 649639010099 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 649639010100 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 649639010101 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 649639010102 dimer interface [polypeptide binding]; other site 649639010103 motif 1; other site 649639010104 active site 649639010105 motif 2; other site 649639010106 motif 3; other site 649639010107 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 649639010108 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 649639010109 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 649639010110 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 649639010111 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 649639010112 phosphopeptide binding site; other site 649639010113 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 649639010114 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 649639010115 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 649639010116 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 649639010117 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 649639010118 phosphopeptide binding site; other site 649639010119 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 649639010120 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 649639010121 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 649639010122 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 649639010123 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 649639010124 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 649639010125 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 649639010126 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 649639010127 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 649639010128 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 649639010129 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 649639010130 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 649639010131 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 649639010132 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649639010133 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649639010134 active site 649639010135 ATP binding site [chemical binding]; other site 649639010136 substrate binding site [chemical binding]; other site 649639010137 activation loop (A-loop); other site 649639010138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649639010139 TPR motif; other site 649639010140 binding surface 649639010141 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 649639010142 active site 649639010143 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 649639010144 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 649639010145 trimer interface [polypeptide binding]; other site 649639010146 active site 649639010147 CoA binding site [chemical binding]; other site 649639010148 pyrophosphatase PpaX; Provisional; Region: PRK13288 649639010149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639010150 motif II; other site 649639010151 Nucleoside recognition; Region: Gate; pfam07670 649639010152 Nucleoside recognition; Region: Gate; pfam07670 649639010153 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 649639010154 HPr kinase/phosphorylase; Provisional; Region: PRK05428 649639010155 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 649639010156 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 649639010157 Hpr binding site; other site 649639010158 active site 649639010159 homohexamer subunit interaction site [polypeptide binding]; other site 649639010160 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 649639010161 Uncharacterized conserved protein [Function unknown]; Region: COG3595 649639010162 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 649639010163 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 649639010164 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 649639010165 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 649639010166 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 649639010167 excinuclease ABC subunit B; Provisional; Region: PRK05298 649639010168 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649639010169 ATP binding site [chemical binding]; other site 649639010170 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 649639010171 putative Mg++ binding site [ion binding]; other site 649639010172 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649639010173 nucleotide binding region [chemical binding]; other site 649639010174 ATP-binding site [chemical binding]; other site 649639010175 Ultra-violet resistance protein B; Region: UvrB; pfam12344 649639010176 UvrB/uvrC motif; Region: UVR; pfam02151 649639010177 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 649639010178 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 649639010179 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 649639010180 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 649639010181 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 649639010182 protein binding site [polypeptide binding]; other site 649639010183 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 649639010184 Catalytic dyad [active] 649639010185 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649639010186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 649639010187 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 649639010188 Peptidase family M23; Region: Peptidase_M23; pfam01551 649639010189 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 649639010190 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 649639010191 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 649639010192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639010193 Walker A/P-loop; other site 649639010194 ATP binding site [chemical binding]; other site 649639010195 Q-loop/lid; other site 649639010196 ABC transporter signature motif; other site 649639010197 Walker B; other site 649639010198 D-loop; other site 649639010199 H-loop/switch region; other site 649639010200 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 649639010201 Uncharacterized conserved protein [Function unknown]; Region: COG1284 649639010202 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 649639010203 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 649639010204 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 649639010205 peptide chain release factor 2; Validated; Region: prfB; PRK00578 649639010206 PCRF domain; Region: PCRF; pfam03462 649639010207 RF-1 domain; Region: RF-1; pfam00472 649639010208 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 649639010209 DEAD/DEAH box helicase; Region: DEAD; pfam00270 649639010210 ATP binding site [chemical binding]; other site 649639010211 putative Mg++ binding site [ion binding]; other site 649639010212 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 649639010213 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 649639010214 nucleotide binding region [chemical binding]; other site 649639010215 ATP-binding site [chemical binding]; other site 649639010216 SEC-C motif; Region: SEC-C; pfam02810 649639010217 transcriptional antiterminator BglG; Provisional; Region: PRK09772 649639010218 CAT RNA binding domain; Region: CAT_RBD; smart01061 649639010219 PRD domain; Region: PRD; pfam00874 649639010220 PRD domain; Region: PRD; pfam00874 649639010221 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 649639010222 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 649639010223 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 649639010224 active site turn [active] 649639010225 phosphorylation site [posttranslational modification] 649639010226 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 649639010227 HPr interaction site; other site 649639010228 glycerol kinase (GK) interaction site [polypeptide binding]; other site 649639010229 active site 649639010230 phosphorylation site [posttranslational modification] 649639010231 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 649639010232 30S subunit binding site; other site 649639010233 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 649639010234 DNA-binding site [nucleotide binding]; DNA binding site 649639010235 RNA-binding motif; other site 649639010236 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 649639010237 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 649639010238 active site 649639010239 dimer interface [polypeptide binding]; other site 649639010240 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 649639010241 Ligand Binding Site [chemical binding]; other site 649639010242 Molecular Tunnel; other site 649639010243 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 649639010244 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 649639010245 dimer interface [polypeptide binding]; other site 649639010246 ssDNA binding site [nucleotide binding]; other site 649639010247 tetramer (dimer of dimers) interface [polypeptide binding]; other site 649639010248 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 649639010249 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 649639010250 Putative motility protein; Region: YjfB_motility; pfam14070 649639010251 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 649639010252 flagellar protein FliS; Validated; Region: fliS; PRK05685 649639010253 flagellar capping protein; Validated; Region: fliD; PRK07737 649639010254 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 649639010255 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 649639010256 FlaG protein; Region: FlaG; cl00591 649639010257 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 649639010258 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 649639010259 inhibitor-cofactor binding pocket; inhibition site 649639010260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639010261 catalytic residue [active] 649639010262 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649639010263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649639010264 NAD(P) binding site [chemical binding]; other site 649639010265 active site 649639010266 pseudaminic acid synthase; Region: PseI; TIGR03586 649639010267 NeuB family; Region: NeuB; pfam03102 649639010268 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 649639010269 NeuB binding interface [polypeptide binding]; other site 649639010270 putative substrate binding site [chemical binding]; other site 649639010271 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 649639010272 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 649639010273 ligand binding site; other site 649639010274 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 649639010275 ATP-grasp domain; Region: ATP-grasp_4; cl17255 649639010276 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 649639010277 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 649639010278 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639010279 motif II; other site 649639010280 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 649639010281 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 649639010282 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 649639010283 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 649639010284 active site 649639010285 nucleotide binding site [chemical binding]; other site 649639010286 HIGH motif; other site 649639010287 KMSKS motif; other site 649639010288 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649639010289 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649639010290 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 649639010291 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 649639010292 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 649639010293 active site 649639010294 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 649639010295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 649639010296 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 649639010297 NAD(P) binding site [chemical binding]; other site 649639010298 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 649639010299 homodimer interface [polypeptide binding]; other site 649639010300 substrate binding site [chemical binding]; other site 649639010301 active site 649639010302 flagellin; Provisional; Region: PRK12804 649639010303 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 649639010304 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 649639010305 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649639010306 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649639010307 DNA binding residues [nucleotide binding] 649639010308 dimerization interface [polypeptide binding]; other site 649639010309 carbon storage regulator; Provisional; Region: PRK01712 649639010310 flagellar assembly protein FliW; Provisional; Region: PRK13285 649639010311 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 649639010312 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 649639010313 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 649639010314 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 649639010315 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 649639010316 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 649639010317 FlgN protein; Region: FlgN; pfam05130 649639010318 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 649639010319 flagellar operon protein TIGR03826; Region: YvyF 649639010320 comF family protein; Region: comF; TIGR00201 649639010321 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 649639010322 active site 649639010323 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 649639010324 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649639010325 ATP binding site [chemical binding]; other site 649639010326 putative Mg++ binding site [ion binding]; other site 649639010327 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649639010328 nucleotide binding region [chemical binding]; other site 649639010329 ATP-binding site [chemical binding]; other site 649639010330 EDD domain protein, DegV family; Region: DegV; TIGR00762 649639010331 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 649639010332 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649639010333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639010334 active site 649639010335 phosphorylation site [posttranslational modification] 649639010336 intermolecular recognition site; other site 649639010337 dimerization interface [polypeptide binding]; other site 649639010338 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649639010339 DNA binding residues [nucleotide binding] 649639010340 dimerization interface [polypeptide binding]; other site 649639010341 Sensor protein DegS; Region: DegS; pfam05384 649639010342 Histidine kinase; Region: HisKA_3; pfam07730 649639010343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639010344 ATP binding site [chemical binding]; other site 649639010345 Mg2+ binding site [ion binding]; other site 649639010346 G-X-G motif; other site 649639010347 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 649639010348 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 649639010349 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 649639010350 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649639010351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 649639010352 phosphorylation site [posttranslational modification] 649639010353 dimer interface [polypeptide binding]; other site 649639010354 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 649639010355 Protein of unknown function (DUF342); Region: DUF342; pfam03961 649639010356 Transcriptional regulator [Transcription]; Region: LytR; COG1316 649639010357 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 649639010358 Bacterial sugar transferase; Region: Bac_transf; pfam02397 649639010359 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 649639010360 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 649639010361 active site 649639010362 tetramer interface; other site 649639010363 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 649639010364 Lysozyme subfamily 2; Region: LYZ2; smart00047 649639010365 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 649639010366 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 649639010367 substrate binding site; other site 649639010368 tetramer interface; other site 649639010369 Methyltransferase domain; Region: Methyltransf_24; pfam13578 649639010370 Nucleoporin complex subunit 54; Region: Nup54; pfam13874 649639010371 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 649639010372 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 649639010373 active site 649639010374 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649639010375 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 649639010376 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 649639010377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649639010378 TPR motif; other site 649639010379 Tetratricopeptide repeat; Region: TPR_16; pfam13432 649639010380 binding surface 649639010381 TPR repeat; Region: TPR_11; pfam13414 649639010382 Phosphotransferase enzyme family; Region: APH; pfam01636 649639010383 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 649639010384 substrate binding site [chemical binding]; other site 649639010385 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 649639010386 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 649639010387 active site 649639010388 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649639010389 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 649639010390 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 649639010391 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 649639010392 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 649639010393 Walker A/P-loop; other site 649639010394 ATP binding site [chemical binding]; other site 649639010395 Q-loop/lid; other site 649639010396 ABC transporter signature motif; other site 649639010397 Walker B; other site 649639010398 D-loop; other site 649639010399 H-loop/switch region; other site 649639010400 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 649639010401 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 649639010402 Walker A/P-loop; other site 649639010403 ATP binding site [chemical binding]; other site 649639010404 Q-loop/lid; other site 649639010405 ABC transporter signature motif; other site 649639010406 Walker B; other site 649639010407 D-loop; other site 649639010408 H-loop/switch region; other site 649639010409 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 649639010410 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 649639010411 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 649639010412 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 649639010413 active site 649639010414 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 649639010415 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649639010416 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649639010417 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 649639010418 putative ADP-binding pocket [chemical binding]; other site 649639010419 CpXC protein; Region: CpXC; pfam14353 649639010420 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 649639010421 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 649639010422 active site 649639010423 catalytic site [active] 649639010424 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 649639010425 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 649639010426 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 649639010427 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 649639010428 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 649639010429 conserved hypothetical protein; Region: MJ1255; TIGR00661 649639010430 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 649639010431 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 649639010432 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 649639010433 active site 649639010434 substrate binding site [chemical binding]; other site 649639010435 metal binding site [ion binding]; metal-binding site 649639010436 PAS domain S-box; Region: sensory_box; TIGR00229 649639010437 PAS domain S-box; Region: sensory_box; TIGR00229 649639010438 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649639010439 putative active site [active] 649639010440 heme pocket [chemical binding]; other site 649639010441 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649639010442 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649639010443 metal binding site [ion binding]; metal-binding site 649639010444 active site 649639010445 I-site; other site 649639010446 ThiC-associated domain; Region: ThiC-associated; pfam13667 649639010447 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 649639010448 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 649639010449 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649639010450 dimerization interface [polypeptide binding]; other site 649639010451 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 649639010452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639010453 phosphorylation site [posttranslational modification] 649639010454 dimer interface [polypeptide binding]; other site 649639010455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639010456 ATP binding site [chemical binding]; other site 649639010457 Mg2+ binding site [ion binding]; other site 649639010458 G-X-G motif; other site 649639010459 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 649639010460 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 649639010461 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 649639010462 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 649639010463 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 649639010464 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 649639010465 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 649639010466 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 649639010467 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 649639010468 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 649639010469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 649639010470 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 649639010471 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649639010472 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649639010473 HAMP domain; Region: HAMP; pfam00672 649639010474 dimerization interface [polypeptide binding]; other site 649639010475 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649639010476 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649639010477 dimer interface [polypeptide binding]; other site 649639010478 putative CheW interface [polypeptide binding]; other site 649639010479 Membrane transport protein; Region: Mem_trans; cl09117 649639010480 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 649639010481 DNA-binding site [nucleotide binding]; DNA binding site 649639010482 RNA-binding motif; other site 649639010483 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649639010484 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649639010485 non-specific DNA binding site [nucleotide binding]; other site 649639010486 salt bridge; other site 649639010487 sequence-specific DNA binding site [nucleotide binding]; other site 649639010488 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649639010489 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 649639010490 binding surface 649639010491 TPR motif; other site 649639010492 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 649639010493 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 649639010494 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 649639010495 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 649639010496 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649639010497 putative active site [active] 649639010498 heme pocket [chemical binding]; other site 649639010499 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649639010500 PAS fold; Region: PAS_3; pfam08447 649639010501 putative active site [active] 649639010502 heme pocket [chemical binding]; other site 649639010503 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649639010504 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649639010505 metal binding site [ion binding]; metal-binding site 649639010506 active site 649639010507 I-site; other site 649639010508 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649639010509 Histidine kinase N terminal; Region: HisK_N; pfam09385 649639010510 Protein of unknown function (DUF456); Region: DUF456; pfam04306 649639010511 Predicted integral membrane protein [Function unknown]; Region: COG5652 649639010512 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 649639010513 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649639010514 binding surface 649639010515 Tetratricopeptide repeat; Region: TPR_16; pfam13432 649639010516 TPR motif; other site 649639010517 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 649639010518 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 649639010519 NAD binding site [chemical binding]; other site 649639010520 substrate binding site [chemical binding]; other site 649639010521 homodimer interface [polypeptide binding]; other site 649639010522 active site 649639010523 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 649639010524 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 649639010525 NADP binding site [chemical binding]; other site 649639010526 active site 649639010527 putative substrate binding site [chemical binding]; other site 649639010528 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 649639010529 UDP-glucose 4-epimerase; Region: PLN02240 649639010530 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 649639010531 NAD binding site [chemical binding]; other site 649639010532 homodimer interface [polypeptide binding]; other site 649639010533 active site 649639010534 substrate binding site [chemical binding]; other site 649639010535 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 649639010536 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 649639010537 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 649639010538 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 649639010539 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 649639010540 metal binding site [ion binding]; metal-binding site 649639010541 putative dimer interface [polypeptide binding]; other site 649639010542 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 649639010543 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 649639010544 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 649639010545 active site 649639010546 trimer interface [polypeptide binding]; other site 649639010547 allosteric site; other site 649639010548 active site lid [active] 649639010549 hexamer (dimer of trimers) interface [polypeptide binding]; other site 649639010550 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 649639010551 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 649639010552 active site 649639010553 dimer interface [polypeptide binding]; other site 649639010554 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 649639010555 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649639010556 DNA-binding site [nucleotide binding]; DNA binding site 649639010557 UTRA domain; Region: UTRA; pfam07702 649639010558 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 649639010559 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 649639010560 substrate binding site [chemical binding]; other site 649639010561 ATP binding site [chemical binding]; other site 649639010562 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 649639010563 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 649639010564 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649639010565 active site 649639010566 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 649639010567 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 649639010568 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 649639010569 putative active site [active] 649639010570 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649639010571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639010572 dimer interface [polypeptide binding]; other site 649639010573 conserved gate region; other site 649639010574 putative PBP binding loops; other site 649639010575 ABC-ATPase subunit interface; other site 649639010576 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 649639010577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639010578 dimer interface [polypeptide binding]; other site 649639010579 conserved gate region; other site 649639010580 putative PBP binding loops; other site 649639010581 ABC-ATPase subunit interface; other site 649639010582 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649639010583 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649639010584 PAS domain; Region: PAS; smart00091 649639010585 PAS domain; Region: PAS_9; pfam13426 649639010586 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649639010587 PilZ domain; Region: PilZ; pfam07238 649639010588 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 649639010589 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 649639010590 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 649639010591 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 649639010592 HSP70 interaction site [polypeptide binding]; other site 649639010593 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649639010594 binding surface 649639010595 Tetratricopeptide repeat; Region: TPR_16; pfam13432 649639010596 TPR motif; other site 649639010597 Tetratricopeptide repeat; Region: TPR_16; pfam13432 649639010598 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 649639010599 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 649639010600 nucleotide binding site [chemical binding]; other site 649639010601 stage V sporulation protein K; Region: spore_V_K; TIGR02881 649639010602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639010603 Walker A motif; other site 649639010604 ATP binding site [chemical binding]; other site 649639010605 Walker B motif; other site 649639010606 arginine finger; other site 649639010607 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 649639010608 HSP70 interaction site [polypeptide binding]; other site 649639010609 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649639010610 binding surface 649639010611 TPR motif; other site 649639010612 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 649639010613 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 649639010614 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 649639010615 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 649639010616 NAD(P) binding site [chemical binding]; other site 649639010617 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 649639010618 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 649639010619 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 649639010620 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 649639010621 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 649639010622 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 649639010623 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 649639010624 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 649639010625 Double zinc ribbon; Region: DZR; pfam12773 649639010626 Ribosome receptor lysine/proline rich region; Region: Rib_recp_KP_reg; pfam05104 649639010627 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 649639010628 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 649639010629 Double zinc ribbon; Region: DZR; pfam12773 649639010630 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 649639010631 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649639010632 Interdomain contacts; other site 649639010633 Cytokine receptor motif; other site 649639010634 Striatin family; Region: Striatin; pfam08232 649639010635 Trehalose utilisation; Region: ThuA; pfam06283 649639010636 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 649639010637 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 649639010638 Cellulose Binding Domain Type IV; Region: CBD_IV; smart00606 649639010639 metal binding site [ion binding]; metal-binding site 649639010640 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 649639010641 sugar binding site [chemical binding]; other site 649639010642 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 649639010643 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649639010644 putative metal binding site [ion binding]; other site 649639010645 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 649639010646 homodimer interface [polypeptide binding]; other site 649639010647 putative GKAP docking site [polypeptide binding]; other site 649639010648 methionine sulfoxide reductase A; Provisional; Region: PRK14054 649639010649 methionine sulfoxide reductase B; Provisional; Region: PRK00222 649639010650 SelR domain; Region: SelR; pfam01641 649639010651 Nuclease-related domain; Region: NERD; pfam08378 649639010652 ferrochelatase; Reviewed; Region: hemH; PRK00035 649639010653 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 649639010654 C-terminal domain interface [polypeptide binding]; other site 649639010655 active site 649639010656 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 649639010657 active site 649639010658 N-terminal domain interface [polypeptide binding]; other site 649639010659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639010660 ATP binding site [chemical binding]; other site 649639010661 Mg2+ binding site [ion binding]; other site 649639010662 G-X-G motif; other site 649639010663 dihydrodipicolinate synthase; Region: dapA; TIGR00674 649639010664 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 649639010665 inhibitor site; inhibition site 649639010666 active site 649639010667 dimer interface [polypeptide binding]; other site 649639010668 catalytic residue [active] 649639010669 allantoate amidohydrolase; Reviewed; Region: PRK09290 649639010670 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 649639010671 active site 649639010672 metal binding site [ion binding]; metal-binding site 649639010673 dimer interface [polypeptide binding]; other site 649639010674 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 649639010675 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649639010676 active site 649639010677 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 649639010678 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 649639010679 TM-ABC transporter signature motif; other site 649639010680 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 649639010681 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649639010682 Walker A/P-loop; other site 649639010683 ATP binding site [chemical binding]; other site 649639010684 Q-loop/lid; other site 649639010685 ABC transporter signature motif; other site 649639010686 Walker B; other site 649639010687 D-loop; other site 649639010688 H-loop/switch region; other site 649639010689 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 649639010690 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 649639010691 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 649639010692 ligand binding site [chemical binding]; other site 649639010693 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 649639010694 aspartate aminotransferase; Provisional; Region: PRK05764 649639010695 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 649639010696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639010697 homodimer interface [polypeptide binding]; other site 649639010698 catalytic residue [active] 649639010699 Transcriptional regulators [Transcription]; Region: FadR; COG2186 649639010700 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649639010701 DNA-binding site [nucleotide binding]; DNA binding site 649639010702 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 649639010703 mannonate dehydratase; Region: uxuA; TIGR00695 649639010704 mannonate dehydratase; Provisional; Region: PRK03906 649639010705 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 649639010706 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 649639010707 active site 649639010708 intersubunit interface [polypeptide binding]; other site 649639010709 catalytic residue [active] 649639010710 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 649639010711 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 649639010712 substrate binding site [chemical binding]; other site 649639010713 ATP binding site [chemical binding]; other site 649639010714 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 649639010715 Nuclease-related domain; Region: NERD; pfam08378 649639010716 Protein of unknown function (DUF342); Region: DUF342; pfam03961 649639010717 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649639010718 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649639010719 active site 649639010720 catalytic tetrad [active] 649639010721 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649639010722 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 649639010723 active site 649639010724 metal binding site [ion binding]; metal-binding site 649639010725 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 649639010726 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 649639010727 active site 649639010728 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 649639010729 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 649639010730 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 649639010731 iron-sulfur cluster [ion binding]; other site 649639010732 [2Fe-2S] cluster binding site [ion binding]; other site 649639010733 MMPL family; Region: MMPL; pfam03176 649639010734 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 649639010735 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 649639010736 TrkA-C domain; Region: TrkA_C; pfam02080 649639010737 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 649639010738 TrkA-C domain; Region: TrkA_C; pfam02080 649639010739 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 649639010740 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 649639010741 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 649639010742 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 649639010743 putative active site [active] 649639010744 putative substrate binding site [chemical binding]; other site 649639010745 putative cosubstrate binding site; other site 649639010746 catalytic site [active] 649639010747 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 649639010748 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 649639010749 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649639010750 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649639010751 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 649639010752 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 649639010753 Predicted membrane protein [Function unknown]; Region: COG1511 649639010754 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 649639010755 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227 649639010756 carbohydrate binding site [chemical binding]; other site 649639010757 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 649639010758 carbohydrate binding site [chemical binding]; other site 649639010759 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 649639010760 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 649639010761 active site 649639010762 catalytic site [active] 649639010763 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 649639010764 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 649639010765 carbohydrate binding site [chemical binding]; other site 649639010766 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 649639010767 carbohydrate binding site [chemical binding]; other site 649639010768 trehalose synthase; Region: treS_nterm; TIGR02456 649639010769 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 649639010770 active site 649639010771 catalytic site [active] 649639010772 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 649639010773 basic region leucin zipper; Region: BRLZ; smart00338 649639010774 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 649639010775 putative alpha-glucosidase; Provisional; Region: PRK10658 649639010776 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 649639010777 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 649639010778 trimer interface [polypeptide binding]; other site 649639010779 active site 649639010780 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 649639010781 catalytic site [active] 649639010782 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649639010783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 649639010784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639010785 dimer interface [polypeptide binding]; other site 649639010786 conserved gate region; other site 649639010787 putative PBP binding loops; other site 649639010788 ABC-ATPase subunit interface; other site 649639010789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639010790 dimer interface [polypeptide binding]; other site 649639010791 conserved gate region; other site 649639010792 putative PBP binding loops; other site 649639010793 ABC-ATPase subunit interface; other site 649639010794 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649639010795 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 649639010796 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649639010797 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649639010798 DNA binding site [nucleotide binding] 649639010799 domain linker motif; other site 649639010800 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649639010801 dimerization interface [polypeptide binding]; other site 649639010802 ligand binding site [chemical binding]; other site 649639010803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639010804 Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460 649639010805 active site 649639010806 motif I; other site 649639010807 motif II; other site 649639010808 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639010809 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649639010810 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 649639010811 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649639010812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639010813 dimer interface [polypeptide binding]; other site 649639010814 conserved gate region; other site 649639010815 putative PBP binding loops; other site 649639010816 ABC-ATPase subunit interface; other site 649639010817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639010818 dimer interface [polypeptide binding]; other site 649639010819 conserved gate region; other site 649639010820 putative PBP binding loops; other site 649639010821 ABC-ATPase subunit interface; other site 649639010822 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 649639010823 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 649639010824 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 649639010825 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 649639010826 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 649639010827 Predicted transcriptional regulators [Transcription]; Region: COG1733 649639010828 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 649639010829 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 649639010830 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649639010831 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 649639010832 putative active site [active] 649639010833 heme pocket [chemical binding]; other site 649639010834 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649639010835 putative active site [active] 649639010836 heme pocket [chemical binding]; other site 649639010837 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649639010838 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649639010839 metal binding site [ion binding]; metal-binding site 649639010840 active site 649639010841 I-site; other site 649639010842 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649639010843 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649639010844 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 649639010845 Walker A/P-loop; other site 649639010846 ATP binding site [chemical binding]; other site 649639010847 Q-loop/lid; other site 649639010848 ABC transporter signature motif; other site 649639010849 Walker B; other site 649639010850 D-loop; other site 649639010851 H-loop/switch region; other site 649639010852 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 649639010853 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 649639010854 methionine sulfoxide reductase A; Provisional; Region: PRK14054 649639010855 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 649639010856 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 649639010857 Repair protein; Region: Repair_PSII; pfam04536 649639010858 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 649639010859 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 649639010860 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649639010861 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649639010862 dimer interface [polypeptide binding]; other site 649639010863 putative CheW interface [polypeptide binding]; other site 649639010864 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 649639010865 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 649639010866 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 649639010867 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 649639010868 generic binding surface I; other site 649639010869 generic binding surface II; other site 649639010870 Staphylococcal nuclease homologues; Region: SNc; smart00318 649639010871 Catalytic site; other site 649639010872 Staphylococcal nuclease homologue; Region: SNase; pfam00565 649639010873 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649639010874 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649639010875 dimer interface [polypeptide binding]; other site 649639010876 putative CheW interface [polypeptide binding]; other site 649639010877 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649639010878 Beta-lactamase; Region: Beta-lactamase; pfam00144 649639010879 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 649639010880 KaiC; Region: KaiC; pfam06745 649639010881 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 649639010882 Walker A motif; other site 649639010883 Walker A motif; other site 649639010884 ATP binding site [chemical binding]; other site 649639010885 Walker B motif; other site 649639010886 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649639010887 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649639010888 DNA binding residues [nucleotide binding] 649639010889 dimerization interface [polypeptide binding]; other site 649639010890 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649639010891 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649639010892 dimerization interface [polypeptide binding]; other site 649639010893 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649639010894 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649639010895 dimer interface [polypeptide binding]; other site 649639010896 putative CheW interface [polypeptide binding]; other site 649639010897 Protein of unknown function (DUF805); Region: DUF805; pfam05656 649639010898 PAS domain S-box; Region: sensory_box; TIGR00229 649639010899 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649639010900 putative active site [active] 649639010901 heme pocket [chemical binding]; other site 649639010902 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649639010903 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649639010904 metal binding site [ion binding]; metal-binding site 649639010905 active site 649639010906 I-site; other site 649639010907 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 649639010908 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 649639010909 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 649639010910 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 649639010911 Helix-turn-helix domain; Region: HTH_28; pfam13518 649639010912 Homeodomain-like domain; Region: HTH_23; cl17451 649639010913 putative transposase OrfB; Reviewed; Region: PHA02517 649639010914 HTH-like domain; Region: HTH_21; pfam13276 649639010915 Integrase core domain; Region: rve; pfam00665 649639010916 Integrase core domain; Region: rve_2; pfam13333 649639010917 amidase; Provisional; Region: PRK06529 649639010918 Amidase; Region: Amidase; pfam01425 649639010919 Predicted membrane protein [Function unknown]; Region: COG1511 649639010920 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 649639010921 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 649639010922 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649639010923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649639010924 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 649639010925 FMN binding site [chemical binding]; other site 649639010926 dimer interface [polypeptide binding]; other site 649639010927 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 649639010928 FMN binding site [chemical binding]; other site 649639010929 dimer interface [polypeptide binding]; other site 649639010930 Sporulation inhibitor A; Region: Sda; pfam08970 649639010931 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649639010932 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649639010933 non-specific DNA binding site [nucleotide binding]; other site 649639010934 salt bridge; other site 649639010935 sequence-specific DNA binding site [nucleotide binding]; other site 649639010936 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649639010937 Coenzyme A binding pocket [chemical binding]; other site 649639010938 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 649639010939 YfzA-like protein; Region: YfzA; pfam14118 649639010940 Predicted transcriptional regulators [Transcription]; Region: COG1725 649639010941 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649639010942 DNA-binding site [nucleotide binding]; DNA binding site 649639010943 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649639010944 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 649639010945 Walker A/P-loop; other site 649639010946 ATP binding site [chemical binding]; other site 649639010947 Q-loop/lid; other site 649639010948 ABC transporter signature motif; other site 649639010949 Walker B; other site 649639010950 D-loop; other site 649639010951 H-loop/switch region; other site 649639010952 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 649639010953 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 649639010954 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 649639010955 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639010956 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649639010957 DNA binding residues [nucleotide binding] 649639010958 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649639010959 non-specific DNA binding site [nucleotide binding]; other site 649639010960 salt bridge; other site 649639010961 sequence-specific DNA binding site [nucleotide binding]; other site 649639010962 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 649639010963 short chain dehydrogenase; Provisional; Region: PRK07454 649639010964 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 649639010965 NADP binding site [chemical binding]; other site 649639010966 homodimer interface [polypeptide binding]; other site 649639010967 active site 649639010968 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 649639010969 Predicted membrane protein [Function unknown]; Region: COG4682 649639010970 yiaA/B two helix domain; Region: YiaAB; pfam05360 649639010971 yiaA/B two helix domain; Region: YiaAB; pfam05360 649639010972 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 649639010973 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 649639010974 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 649639010975 NADP binding site [chemical binding]; other site 649639010976 NADH(P)-binding; Region: NAD_binding_10; pfam13460 649639010977 active site 649639010978 regulatory binding site [polypeptide binding]; other site 649639010979 SEC-C motif; Region: SEC-C; pfam02810 649639010980 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 649639010981 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 649639010982 Tetratricopeptide repeat; Region: TPR_16; pfam13432 649639010983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649639010984 TPR motif; other site 649639010985 binding surface 649639010986 TPR repeat; Region: TPR_11; pfam13414 649639010987 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 649639010988 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 649639010989 Fatty acid desaturase; Region: FA_desaturase; pfam00487 649639010990 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 649639010991 putative di-iron ligands [ion binding]; other site 649639010992 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639010993 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 649639010994 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639010995 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639010996 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 649639010997 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 649639010998 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 649639010999 transmembrane helices; other site 649639011000 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 649639011001 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 649639011002 Double zinc ribbon; Region: DZR; pfam12773 649639011003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 649639011004 Helix-turn-helix domain; Region: HTH_28; pfam13518 649639011005 Homeodomain-like domain; Region: HTH_23; cl17451 649639011006 putative transposase OrfB; Reviewed; Region: PHA02517 649639011007 HTH-like domain; Region: HTH_21; pfam13276 649639011008 Integrase core domain; Region: rve; pfam00665 649639011009 Integrase core domain; Region: rve_2; pfam13333 649639011010 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 649639011011 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 649639011012 Cytochrome P450; Region: p450; pfam00067 649639011013 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649639011014 Cache domain; Region: Cache_1; pfam02743 649639011015 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 649639011016 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649639011017 dimerization interface [polypeptide binding]; other site 649639011018 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649639011019 dimer interface [polypeptide binding]; other site 649639011020 putative CheW interface [polypeptide binding]; other site 649639011021 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 649639011022 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 649639011023 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 649639011024 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 649639011025 Ligand binding site; other site 649639011026 Putative Catalytic site; other site 649639011027 DXD motif; other site 649639011028 Esterase/lipase [General function prediction only]; Region: COG1647 649639011029 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 649639011030 Transposase IS200 like; Region: Y1_Tnp; pfam01797 649639011031 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 649639011032 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 649639011033 oxidoreductase; Provisional; Region: PRK06196 649639011034 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 649639011035 putative NAD(P) binding site [chemical binding]; other site 649639011036 active site 649639011037 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 649639011038 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639011039 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 649639011040 DNA binding residues [nucleotide binding] 649639011041 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649639011042 non-specific DNA binding site [nucleotide binding]; other site 649639011043 salt bridge; other site 649639011044 sequence-specific DNA binding site [nucleotide binding]; other site 649639011045 ComK protein; Region: ComK; cl11560 649639011046 Short C-terminal domain; Region: SHOCT; pfam09851 649639011047 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 649639011048 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 649639011049 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 649639011050 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 649639011051 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 649639011052 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 649639011053 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 649639011054 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 649639011055 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 649639011056 active site 649639011057 homodimer interface [polypeptide binding]; other site 649639011058 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 649639011059 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649639011060 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 649639011061 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 649639011062 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 649639011063 YcxB-like protein; Region: YcxB; pfam14317 649639011064 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 649639011065 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 649639011066 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 649639011067 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649639011068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649639011069 non-specific DNA binding site [nucleotide binding]; other site 649639011070 salt bridge; other site 649639011071 sequence-specific DNA binding site [nucleotide binding]; other site 649639011072 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 649639011073 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649639011074 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649639011075 non-specific DNA binding site [nucleotide binding]; other site 649639011076 salt bridge; other site 649639011077 sequence-specific DNA binding site [nucleotide binding]; other site 649639011078 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 649639011079 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 649639011080 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649639011081 DNA binding residues [nucleotide binding] 649639011082 dimer interface [polypeptide binding]; other site 649639011083 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 649639011084 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 649639011085 active site 649639011086 catalytic motif [active] 649639011087 Zn binding site [ion binding]; other site 649639011088 DJ-1 family protein; Region: not_thiJ; TIGR01383 649639011089 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 649639011090 conserved cys residue [active] 649639011091 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 649639011092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639011093 H+ Antiporter protein; Region: 2A0121; TIGR00900 649639011094 putative substrate translocation pore; other site 649639011095 Phosphotransferase enzyme family; Region: APH; pfam01636 649639011096 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 649639011097 active site 649639011098 ATP binding site [chemical binding]; other site 649639011099 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 649639011100 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 649639011101 nudix motif; other site 649639011102 Methyltransferase domain; Region: Methyltransf_31; pfam13847 649639011103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639011104 S-adenosylmethionine binding site [chemical binding]; other site 649639011105 Beta-lactamase; Region: Beta-lactamase; pfam00144 649639011106 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649639011107 Nuclease-related domain; Region: NERD; pfam08378 649639011108 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649639011109 dimerization interface [polypeptide binding]; other site 649639011110 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649639011111 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649639011112 dimer interface [polypeptide binding]; other site 649639011113 putative CheW interface [polypeptide binding]; other site 649639011114 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 649639011115 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 649639011116 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 649639011117 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 649639011118 putative dimer interface [polypeptide binding]; other site 649639011119 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649639011120 ligand binding site [chemical binding]; other site 649639011121 Zn binding site [ion binding]; other site 649639011122 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649639011123 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649639011124 non-specific DNA binding site [nucleotide binding]; other site 649639011125 salt bridge; other site 649639011126 sequence-specific DNA binding site [nucleotide binding]; other site 649639011127 YCII-related domain; Region: YCII; cl00999 649639011128 Tubby C 2; Region: Tub_2; cl02043 649639011129 N-acetyltransferase; Region: Acetyltransf_2; cl00949 649639011130 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649639011131 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649639011132 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 649639011133 DinB superfamily; Region: DinB_2; pfam12867 649639011134 Cache domain; Region: Cache_1; pfam02743 649639011135 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649639011136 dimerization interface [polypeptide binding]; other site 649639011137 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649639011138 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649639011139 metal binding site [ion binding]; metal-binding site 649639011140 active site 649639011141 I-site; other site 649639011142 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649639011143 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 649639011144 DinB family; Region: DinB; cl17821 649639011145 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639011146 Coenzyme A binding pocket [chemical binding]; other site 649639011147 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 649639011148 active site lid residues [active] 649639011149 substrate binding pocket [chemical binding]; other site 649639011150 catalytic residues [active] 649639011151 substrate-Mg2+ binding site; other site 649639011152 aspartate-rich region 1; other site 649639011153 aspartate-rich region 2; other site 649639011154 Protein of unknown function (DUF422); Region: DUF422; cl00991 649639011155 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 649639011156 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 649639011157 putative acyl-acceptor binding pocket; other site 649639011158 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 649639011159 DXD motif; other site 649639011160 phytoene desaturase; Region: crtI_fam; TIGR02734 649639011161 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 649639011162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639011163 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 649639011164 active site 649639011165 phosphorylation site [posttranslational modification] 649639011166 intermolecular recognition site; other site 649639011167 dimerization interface [polypeptide binding]; other site 649639011168 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 649639011169 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 649639011170 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649639011171 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639011172 dimer interface [polypeptide binding]; other site 649639011173 phosphorylation site [posttranslational modification] 649639011174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639011175 ATP binding site [chemical binding]; other site 649639011176 Mg2+ binding site [ion binding]; other site 649639011177 G-X-G motif; other site 649639011178 Response regulator receiver domain; Region: Response_reg; pfam00072 649639011179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639011180 active site 649639011181 phosphorylation site [posttranslational modification] 649639011182 intermolecular recognition site; other site 649639011183 dimerization interface [polypeptide binding]; other site 649639011184 Histidine kinase; Region: His_kinase; pfam06580 649639011185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639011186 ATP binding site [chemical binding]; other site 649639011187 Mg2+ binding site [ion binding]; other site 649639011188 G-X-G motif; other site 649639011189 putative transposase OrfB; Reviewed; Region: PHA02517 649639011190 HTH-like domain; Region: HTH_21; pfam13276 649639011191 Integrase core domain; Region: rve; pfam00665 649639011192 Integrase core domain; Region: rve_2; pfam13333 649639011193 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 649639011194 Helix-turn-helix domain; Region: HTH_28; pfam13518 649639011195 Homeodomain-like domain; Region: HTH_23; cl17451 649639011196 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649639011197 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 649639011198 active site 649639011199 metal binding site [ion binding]; metal-binding site 649639011200 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 649639011201 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649639011202 dimerization interface [polypeptide binding]; other site 649639011203 putative DNA binding site [nucleotide binding]; other site 649639011204 putative Zn2+ binding site [ion binding]; other site 649639011205 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 649639011206 Uncharacterized conserved protein [Function unknown]; Region: COG5646 649639011207 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 649639011208 AAA domain; Region: AAA_33; pfam13671 649639011209 active site 649639011210 maltose O-acetyltransferase; Provisional; Region: PRK10092 649639011211 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 649639011212 active site 649639011213 substrate binding site [chemical binding]; other site 649639011214 trimer interface [polypeptide binding]; other site 649639011215 CoA binding site [chemical binding]; other site 649639011216 putative transposase OrfB; Reviewed; Region: PHA02517 649639011217 HTH-like domain; Region: HTH_21; pfam13276 649639011218 Integrase core domain; Region: rve; pfam00665 649639011219 Integrase core domain; Region: rve_2; pfam13333 649639011220 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 649639011221 Helix-turn-helix domain; Region: HTH_28; pfam13518 649639011222 Homeodomain-like domain; Region: HTH_23; cl17451 649639011223 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 649639011224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649639011225 putative substrate translocation pore; other site 649639011226 Ryanodine Receptor TM 4-6; Region: RR_TM4-6; pfam06459 649639011227 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 649639011228 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 649639011229 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649639011230 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639011231 dimer interface [polypeptide binding]; other site 649639011232 phosphorylation site [posttranslational modification] 649639011233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639011234 ATP binding site [chemical binding]; other site 649639011235 Mg2+ binding site [ion binding]; other site 649639011236 G-X-G motif; other site 649639011237 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639011238 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649639011239 Coenzyme A binding pocket [chemical binding]; other site 649639011240 DinB superfamily; Region: DinB_2; pfam12867 649639011241 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 649639011242 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 649639011243 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649639011244 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 649639011245 dimer interface [polypeptide binding]; other site 649639011246 putative metal binding site [ion binding]; other site 649639011247 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649639011248 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639011249 Coenzyme A binding pocket [chemical binding]; other site 649639011250 Methyltransferase domain; Region: Methyltransf_23; pfam13489 649639011251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639011252 S-adenosylmethionine binding site [chemical binding]; other site 649639011253 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 649639011254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649639011255 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 649639011256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639011257 S-adenosylmethionine binding site [chemical binding]; other site 649639011258 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 649639011259 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 649639011260 NodB motif; other site 649639011261 putative active site [active] 649639011262 putative catalytic site [active] 649639011263 putative Zn binding site [ion binding]; other site 649639011264 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 649639011265 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649639011266 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 649639011267 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649639011268 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649639011269 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649639011270 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 649639011271 NlpC/P60 family; Region: NLPC_P60; pfam00877 649639011272 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 649639011273 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 649639011274 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 649639011275 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 649639011276 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 649639011277 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 649639011278 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 649639011279 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 649639011280 rod shape-determining protein Mbl; Provisional; Region: PRK13928 649639011281 MreB and similar proteins; Region: MreB_like; cd10225 649639011282 nucleotide binding site [chemical binding]; other site 649639011283 Mg binding site [ion binding]; other site 649639011284 putative protofilament interaction site [polypeptide binding]; other site 649639011285 RodZ interaction site [polypeptide binding]; other site 649639011286 Stage III sporulation protein D; Region: SpoIIID; pfam12116 649639011287 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 649639011288 Peptidase family M23; Region: Peptidase_M23; pfam01551 649639011289 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 649639011290 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 649639011291 stage II sporulation protein D; Region: spore_II_D; TIGR02870 649639011292 Stage II sporulation protein; Region: SpoIID; pfam08486 649639011293 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 649639011294 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 649639011295 hinge; other site 649639011296 active site 649639011297 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 649639011298 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 649639011299 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 649639011300 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 649639011301 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 649639011302 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 649639011303 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 649639011304 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 649639011305 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 649639011306 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 649639011307 NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; pfam00499 649639011308 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 649639011309 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 649639011310 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 649639011311 4Fe-4S binding domain; Region: Fer4; pfam00037 649639011312 4Fe-4S binding domain; Region: Fer4; cl02805 649639011313 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 649639011314 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 649639011315 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 649639011316 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 649639011317 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 649639011318 NADH dehydrogenase subunit B; Validated; Region: PRK06411 649639011319 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 649639011320 Transposase IS200 like; Region: Y1_Tnp; cl00848 649639011321 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 649639011322 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 649639011323 gamma subunit interface [polypeptide binding]; other site 649639011324 epsilon subunit interface [polypeptide binding]; other site 649639011325 LBP interface [polypeptide binding]; other site 649639011326 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 649639011327 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 649639011328 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 649639011329 alpha subunit interaction interface [polypeptide binding]; other site 649639011330 Walker A motif; other site 649639011331 ATP binding site [chemical binding]; other site 649639011332 Walker B motif; other site 649639011333 inhibitor binding site; inhibition site 649639011334 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 649639011335 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 649639011336 core domain interface [polypeptide binding]; other site 649639011337 delta subunit interface [polypeptide binding]; other site 649639011338 epsilon subunit interface [polypeptide binding]; other site 649639011339 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 649639011340 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 649639011341 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 649639011342 beta subunit interaction interface [polypeptide binding]; other site 649639011343 Walker A motif; other site 649639011344 ATP binding site [chemical binding]; other site 649639011345 Walker B motif; other site 649639011346 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 649639011347 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 649639011348 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 649639011349 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 649639011350 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 649639011351 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 649639011352 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 649639011353 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 649639011354 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 649639011355 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 649639011356 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 649639011357 putative active site [active] 649639011358 catalytic triad [active] 649639011359 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 649639011360 putative integrin binding motif; other site 649639011361 PA/protease domain interface [polypeptide binding]; other site 649639011362 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 649639011363 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 649639011364 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649639011365 active site 649639011366 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649639011367 catalytic tetrad [active] 649639011368 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649639011369 extended (e) SDRs; Region: SDR_e; cd08946 649639011370 NAD(P) binding site [chemical binding]; other site 649639011371 active site 649639011372 substrate binding site [chemical binding]; other site 649639011373 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 649639011374 active site 649639011375 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 649639011376 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 649639011377 dimer interface [polypeptide binding]; other site 649639011378 active site 649639011379 glycine-pyridoxal phosphate binding site [chemical binding]; other site 649639011380 folate binding site [chemical binding]; other site 649639011381 hypothetical protein; Provisional; Region: PRK13690 649639011382 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 649639011383 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 649639011384 Low molecular weight phosphatase family; Region: LMWPc; cd00115 649639011385 active site 649639011386 Predicted membrane protein [Function unknown]; Region: COG1971 649639011387 Domain of unknown function DUF; Region: DUF204; pfam02659 649639011388 Domain of unknown function DUF; Region: DUF204; pfam02659 649639011389 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 649639011390 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 649639011391 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649639011392 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 649639011393 nudix motif; other site 649639011394 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 649639011395 Transposase, Mutator family; Region: Transposase_mut; pfam00872 649639011396 MULE transposase domain; Region: MULE; pfam10551 649639011397 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 649639011398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639011399 S-adenosylmethionine binding site [chemical binding]; other site 649639011400 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 649639011401 peptide chain release factor 1; Validated; Region: prfA; PRK00591 649639011402 This domain is found in peptide chain release factors; Region: PCRF; smart00937 649639011403 RF-1 domain; Region: RF-1; pfam00472 649639011404 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 649639011405 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 649639011406 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649639011407 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 649639011408 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 649639011409 thymidine kinase; Provisional; Region: PRK04296 649639011410 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 649639011411 transcription termination factor Rho; Provisional; Region: rho; PRK09376 649639011412 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 649639011413 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 649639011414 RNA binding site [nucleotide binding]; other site 649639011415 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 649639011416 multimer interface [polypeptide binding]; other site 649639011417 Walker A motif; other site 649639011418 ATP binding site [chemical binding]; other site 649639011419 Walker B motif; other site 649639011420 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 649639011421 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 649639011422 hinge; other site 649639011423 active site 649639011424 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 649639011425 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 649639011426 intersubunit interface [polypeptide binding]; other site 649639011427 active site 649639011428 zinc binding site [ion binding]; other site 649639011429 Na+ binding site [ion binding]; other site 649639011430 Response regulator receiver domain; Region: Response_reg; pfam00072 649639011431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639011432 active site 649639011433 phosphorylation site [posttranslational modification] 649639011434 intermolecular recognition site; other site 649639011435 dimerization interface [polypeptide binding]; other site 649639011436 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 649639011437 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649639011438 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649639011439 DNA binding residues [nucleotide binding] 649639011440 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 649639011441 CTP synthetase; Validated; Region: pyrG; PRK05380 649639011442 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 649639011443 Catalytic site [active] 649639011444 active site 649639011445 UTP binding site [chemical binding]; other site 649639011446 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 649639011447 active site 649639011448 putative oxyanion hole; other site 649639011449 catalytic triad [active] 649639011450 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 649639011451 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 649639011452 B12 binding site [chemical binding]; other site 649639011453 cobalt ligand [ion binding]; other site 649639011454 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 649639011455 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 649639011456 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 649639011457 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 649639011458 Walker A; other site 649639011459 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 649639011460 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 649639011461 FAD binding site [chemical binding]; other site 649639011462 homotetramer interface [polypeptide binding]; other site 649639011463 substrate binding pocket [chemical binding]; other site 649639011464 catalytic base [active] 649639011465 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 649639011466 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 649639011467 FAD binding site [chemical binding]; other site 649639011468 homotetramer interface [polypeptide binding]; other site 649639011469 substrate binding pocket [chemical binding]; other site 649639011470 catalytic base [active] 649639011471 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 649639011472 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 649639011473 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 649639011474 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 649639011475 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 649639011476 dimer interface [polypeptide binding]; other site 649639011477 active site 649639011478 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 649639011479 4Fe-4S binding domain; Region: Fer4_2; pfam12797 649639011480 Cysteine-rich domain; Region: CCG; pfam02754 649639011481 Cysteine-rich domain; Region: CCG; pfam02754 649639011482 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 649639011483 PLD-like domain; Region: PLDc_2; pfam13091 649639011484 putative active site [active] 649639011485 catalytic site [active] 649639011486 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 649639011487 PLD-like domain; Region: PLDc_2; pfam13091 649639011488 putative active site [active] 649639011489 catalytic site [active] 649639011490 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 649639011491 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 649639011492 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639011493 motif II; other site 649639011494 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 649639011495 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 649639011496 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 649639011497 active site 649639011498 HIGH motif; other site 649639011499 KMSK motif region; other site 649639011500 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 649639011501 tRNA binding surface [nucleotide binding]; other site 649639011502 anticodon binding site; other site 649639011503 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 649639011504 spermidine synthase; Provisional; Region: PRK00811 649639011505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639011506 Transglycosylase; Region: Transgly; pfam00912 649639011507 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 649639011508 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 649639011509 YwhD family; Region: YwhD; pfam08741 649639011510 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 649639011511 active site 1 [active] 649639011512 dimer interface [polypeptide binding]; other site 649639011513 hexamer interface [polypeptide binding]; other site 649639011514 active site 2 [active] 649639011515 Uncharacterized conserved protein [Function unknown]; Region: COG3465 649639011516 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 649639011517 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 649639011518 Zn2+ binding site [ion binding]; other site 649639011519 Mg2+ binding site [ion binding]; other site 649639011520 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 649639011521 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 649639011522 putative heme peroxidase; Provisional; Region: PRK12276 649639011523 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 649639011524 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 649639011525 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 649639011526 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 649639011527 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 649639011528 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 649639011529 substrate binding pocket [chemical binding]; other site 649639011530 membrane-bound complex binding site; other site 649639011531 hinge residues; other site 649639011532 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 649639011533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639011534 dimer interface [polypeptide binding]; other site 649639011535 conserved gate region; other site 649639011536 putative PBP binding loops; other site 649639011537 ABC-ATPase subunit interface; other site 649639011538 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 649639011539 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 649639011540 Walker A/P-loop; other site 649639011541 ATP binding site [chemical binding]; other site 649639011542 Q-loop/lid; other site 649639011543 ABC transporter signature motif; other site 649639011544 Walker B; other site 649639011545 D-loop; other site 649639011546 H-loop/switch region; other site 649639011547 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 649639011548 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 649639011549 active site 649639011550 Zn binding site [ion binding]; other site 649639011551 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 649639011552 NADH(P)-binding; Region: NAD_binding_10; pfam13460 649639011553 NAD binding site [chemical binding]; other site 649639011554 active site 649639011555 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 649639011556 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 649639011557 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 649639011558 ligand binding site [chemical binding]; other site 649639011559 active site 649639011560 UGI interface [polypeptide binding]; other site 649639011561 catalytic site [active] 649639011562 Response regulator receiver domain; Region: Response_reg; pfam00072 649639011563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639011564 active site 649639011565 phosphorylation site [posttranslational modification] 649639011566 intermolecular recognition site; other site 649639011567 dimerization interface [polypeptide binding]; other site 649639011568 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 649639011569 ATP-grasp domain; Region: ATP-grasp_4; cl17255 649639011570 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 649639011571 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 649639011572 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 649639011573 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 649639011574 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649639011575 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 649639011576 active site 649639011577 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 649639011578 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 649639011579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 649639011580 Nucleoside recognition; Region: Gate; pfam07670 649639011581 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 649639011582 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 649639011583 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 649639011584 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 649639011585 GTPase RsgA; Reviewed; Region: PRK01889 649639011586 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 649639011587 RNA binding site [nucleotide binding]; other site 649639011588 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 649639011589 GTPase/Zn-binding domain interface [polypeptide binding]; other site 649639011590 GTP/Mg2+ binding site [chemical binding]; other site 649639011591 G4 box; other site 649639011592 G5 box; other site 649639011593 G1 box; other site 649639011594 Switch I region; other site 649639011595 G2 box; other site 649639011596 G3 box; other site 649639011597 Switch II region; other site 649639011598 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 649639011599 homotrimer interaction site [polypeptide binding]; other site 649639011600 putative active site [active] 649639011601 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 649639011602 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 649639011603 putative active site [active] 649639011604 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 649639011605 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 649639011606 pantothenate kinase; Provisional; Region: PRK05439 649639011607 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 649639011608 ATP-binding site [chemical binding]; other site 649639011609 CoA-binding site [chemical binding]; other site 649639011610 Mg2+-binding site [ion binding]; other site 649639011611 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 649639011612 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 649639011613 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 649639011614 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 649639011615 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 649639011616 [2Fe-2S] cluster binding site [ion binding]; other site 649639011617 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 649639011618 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 649639011619 metal binding site [ion binding]; metal-binding site 649639011620 homoserine dehydrogenase; Provisional; Region: PRK06349 649639011621 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 649639011622 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 649639011623 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 649639011624 threonine synthase; Reviewed; Region: PRK06721 649639011625 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 649639011626 homodimer interface [polypeptide binding]; other site 649639011627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639011628 catalytic residue [active] 649639011629 homoserine kinase; Provisional; Region: PRK01212 649639011630 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 649639011631 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 649639011632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639011633 Coenzyme A binding pocket [chemical binding]; other site 649639011634 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 649639011635 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 649639011636 active site 649639011637 HIGH motif; other site 649639011638 nucleotide binding site [chemical binding]; other site 649639011639 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 649639011640 KMSKS motif; other site 649639011641 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 649639011642 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 649639011643 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 649639011644 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 649639011645 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 649639011646 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 649639011647 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 649639011648 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 649639011649 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639011650 Coenzyme A binding pocket [chemical binding]; other site 649639011651 SurA N-terminal domain; Region: SurA_N_3; cl07813 649639011652 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 649639011653 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 649639011654 metal binding site [ion binding]; metal-binding site 649639011655 ligand binding site [chemical binding]; other site 649639011656 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 649639011657 metal binding site [ion binding]; metal-binding site 649639011658 ligand binding site [chemical binding]; other site 649639011659 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 649639011660 Amidinotransferase; Region: Amidinotransf; pfam02274 649639011661 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649639011662 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649639011663 active site 649639011664 catalytic tetrad [active] 649639011665 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 649639011666 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649639011667 FeS/SAM binding site; other site 649639011668 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 649639011669 Class III ribonucleotide reductase; Region: RNR_III; cd01675 649639011670 effector binding site; other site 649639011671 active site 649639011672 Zn binding site [ion binding]; other site 649639011673 glycine loop; other site 649639011674 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 649639011675 dimer interface [polypeptide binding]; other site 649639011676 putative radical transfer pathway; other site 649639011677 diiron center [ion binding]; other site 649639011678 tyrosyl radical; other site 649639011679 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 649639011680 Class I ribonucleotide reductase; Region: RNR_I; cd01679 649639011681 active site 649639011682 dimer interface [polypeptide binding]; other site 649639011683 catalytic residues [active] 649639011684 effector binding site; other site 649639011685 R2 peptide binding site; other site 649639011686 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639011687 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 649639011688 active site 649639011689 motif I; other site 649639011690 motif II; other site 649639011691 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649639011692 PAS domain; Region: PAS_8; pfam13188 649639011693 PAS domain; Region: PAS_9; pfam13426 649639011694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639011695 dimer interface [polypeptide binding]; other site 649639011696 phosphorylation site [posttranslational modification] 649639011697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639011698 ATP binding site [chemical binding]; other site 649639011699 Mg2+ binding site [ion binding]; other site 649639011700 G-X-G motif; other site 649639011701 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 649639011702 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 649639011703 argininosuccinate lyase; Provisional; Region: PRK00855 649639011704 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 649639011705 active sites [active] 649639011706 tetramer interface [polypeptide binding]; other site 649639011707 argininosuccinate synthase; Provisional; Region: PRK13820 649639011708 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 649639011709 ANP binding site [chemical binding]; other site 649639011710 Substrate Binding Site II [chemical binding]; other site 649639011711 Substrate Binding Site I [chemical binding]; other site 649639011712 ornithine carbamoyltransferase; Provisional; Region: PRK00779 649639011713 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 649639011714 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 649639011715 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 649639011716 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 649639011717 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 649639011718 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 649639011719 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 649639011720 ATP-grasp domain; Region: ATP-grasp_4; cl17255 649639011721 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 649639011722 substrate binding site [chemical binding]; other site 649639011723 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 649639011724 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 649639011725 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 649639011726 catalytic site [active] 649639011727 subunit interface [polypeptide binding]; other site 649639011728 acetylornithine aminotransferase; Provisional; Region: PRK02627 649639011729 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 649639011730 inhibitor-cofactor binding pocket; inhibition site 649639011731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649639011732 catalytic residue [active] 649639011733 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 649639011734 nucleotide binding site [chemical binding]; other site 649639011735 N-acetyl-L-glutamate binding site [chemical binding]; other site 649639011736 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 649639011737 heterotetramer interface [polypeptide binding]; other site 649639011738 active site pocket [active] 649639011739 cleavage site 649639011740 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 649639011741 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 649639011742 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 649639011743 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649639011744 Small acid-soluble spore protein H family; Region: SspH; cl06949 649639011745 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639011746 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 649639011747 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639011748 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 649639011749 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639011750 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639011751 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639011752 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 649639011753 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639011754 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 649639011755 active site 649639011756 Glyco_18 domain; Region: Glyco_18; smart00636 649639011757 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 649639011758 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639011759 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649639011760 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649639011761 NAD(P) binding site [chemical binding]; other site 649639011762 active site 649639011763 Predicted amidohydrolase [General function prediction only]; Region: COG0388 649639011764 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 649639011765 putative active site [active] 649639011766 catalytic triad [active] 649639011767 putative dimer interface [polypeptide binding]; other site 649639011768 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 649639011769 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 649639011770 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 649639011771 Spore germination protein; Region: Spore_permease; cl17796 649639011772 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 649639011773 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 649639011774 Walker A/P-loop; other site 649639011775 ATP binding site [chemical binding]; other site 649639011776 Q-loop/lid; other site 649639011777 ABC transporter signature motif; other site 649639011778 Walker B; other site 649639011779 D-loop; other site 649639011780 H-loop/switch region; other site 649639011781 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 649639011782 Walker A/P-loop; other site 649639011783 ATP binding site [chemical binding]; other site 649639011784 Q-loop/lid; other site 649639011785 ABC transporter signature motif; other site 649639011786 Walker B; other site 649639011787 D-loop; other site 649639011788 H-loop/switch region; other site 649639011789 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 649639011790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639011791 dimer interface [polypeptide binding]; other site 649639011792 conserved gate region; other site 649639011793 ABC-ATPase subunit interface; other site 649639011794 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 649639011795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639011796 dimer interface [polypeptide binding]; other site 649639011797 conserved gate region; other site 649639011798 putative PBP binding loops; other site 649639011799 ABC-ATPase subunit interface; other site 649639011800 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 649639011801 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 649639011802 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649639011803 Coenzyme A binding pocket [chemical binding]; other site 649639011804 VanZ like family; Region: VanZ; pfam04892 649639011805 Small acid-soluble spore protein H family; Region: SspH; pfam08141 649639011806 Putative transcription activator [Transcription]; Region: TenA; COG0819 649639011807 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 649639011808 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 649639011809 Walker A/P-loop; other site 649639011810 ATP binding site [chemical binding]; other site 649639011811 Q-loop/lid; other site 649639011812 ABC transporter signature motif; other site 649639011813 Walker B; other site 649639011814 D-loop; other site 649639011815 H-loop/switch region; other site 649639011816 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 649639011817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649639011818 dimer interface [polypeptide binding]; other site 649639011819 conserved gate region; other site 649639011820 putative PBP binding loops; other site 649639011821 ABC-ATPase subunit interface; other site 649639011822 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 649639011823 NMT1/THI5 like; Region: NMT1; pfam09084 649639011824 short chain dehydrogenase; Provisional; Region: PRK06701 649639011825 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 649639011826 NAD binding site [chemical binding]; other site 649639011827 metal binding site [ion binding]; metal-binding site 649639011828 active site 649639011829 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 649639011830 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 649639011831 putative RNA binding site [nucleotide binding]; other site 649639011832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649639011833 S-adenosylmethionine binding site [chemical binding]; other site 649639011834 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649639011835 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649639011836 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649639011837 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649639011838 metal binding site [ion binding]; metal-binding site 649639011839 active site 649639011840 I-site; other site 649639011841 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649639011842 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 649639011843 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 649639011844 putative active site [active] 649639011845 putative metal binding site [ion binding]; other site 649639011846 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 649639011847 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 649639011848 active site 649639011849 catalytic site [active] 649639011850 metal binding site [ion binding]; metal-binding site 649639011851 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 649639011852 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 649639011853 putative active site; other site 649639011854 catalytic triad [active] 649639011855 putative dimer interface [polypeptide binding]; other site 649639011856 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 649639011857 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 649639011858 Protein of unknown function (DUF4023); Region: DUF4023; pfam13215 649639011859 RDD family; Region: RDD; pfam06271 649639011860 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 649639011861 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 649639011862 Protein of unknown function DUF58; Region: DUF58; pfam01882 649639011863 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 649639011864 metal ion-dependent adhesion site (MIDAS); other site 649639011865 MoxR-like ATPases [General function prediction only]; Region: COG0714 649639011866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649639011867 Walker A motif; other site 649639011868 ATP binding site [chemical binding]; other site 649639011869 Walker B motif; other site 649639011870 arginine finger; other site 649639011871 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 649639011872 ribonuclease Z; Region: RNase_Z; TIGR02651 649639011873 Amastin surface glycoprotein; Region: Amastin; cl06401 649639011874 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 649639011875 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 649639011876 peroxiredoxin; Region: AhpC; TIGR03137 649639011877 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 649639011878 dimer interface [polypeptide binding]; other site 649639011879 decamer (pentamer of dimers) interface [polypeptide binding]; other site 649639011880 catalytic triad [active] 649639011881 peroxidatic and resolving cysteines [active] 649639011882 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 649639011883 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 649639011884 catalytic residue [active] 649639011885 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 649639011886 catalytic residues [active] 649639011887 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 649639011888 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649639011889 malate:quinone oxidoreductase; Validated; Region: PRK05257 649639011890 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 649639011891 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649639011892 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 649639011893 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639011894 dimer interface [polypeptide binding]; other site 649639011895 phosphorylation site [posttranslational modification] 649639011896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639011897 ATP binding site [chemical binding]; other site 649639011898 Mg2+ binding site [ion binding]; other site 649639011899 G-X-G motif; other site 649639011900 Sulphur transport; Region: Sulf_transp; pfam04143 649639011901 Sulphur transport; Region: Sulf_transp; pfam04143 649639011902 Nuclease-related domain; Region: NERD; pfam08378 649639011903 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 649639011904 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 649639011905 FtsX-like permease family; Region: FtsX; pfam02687 649639011906 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 649639011907 FtsX-like permease family; Region: FtsX; pfam02687 649639011908 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649639011909 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 649639011910 Walker A/P-loop; other site 649639011911 ATP binding site [chemical binding]; other site 649639011912 Q-loop/lid; other site 649639011913 ABC transporter signature motif; other site 649639011914 Walker B; other site 649639011915 D-loop; other site 649639011916 H-loop/switch region; other site 649639011917 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 649639011918 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649639011919 DNA binding residues [nucleotide binding] 649639011920 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 649639011921 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 649639011922 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 649639011923 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 649639011924 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 649639011925 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 649639011926 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 649639011927 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 649639011928 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 649639011929 catalytic residues [active] 649639011930 catalytic nucleophile [active] 649639011931 Presynaptic Site I dimer interface [polypeptide binding]; other site 649639011932 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 649639011933 Synaptic Flat tetramer interface [polypeptide binding]; other site 649639011934 Synaptic Site I dimer interface [polypeptide binding]; other site 649639011935 DNA binding site [nucleotide binding] 649639011936 Recombinase; Region: Recombinase; pfam07508 649639011937 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 649639011938 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 649639011939 DNA methylase; Region: N6_N4_Mtase; pfam01555 649639011940 Antirestriction protein (ArdA); Region: ArdA; cl01953 649639011941 Domain of unknown function (DUF1817); Region: DUF1817; cl02292 649639011942 PemK-like protein; Region: PemK; pfam02452 649639011943 Superinfection exclusion protein B; Region: SieB; pfam14163 649639011944 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 649639011945 active site 649639011946 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 649639011947 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 649639011948 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649639011949 ATP binding site [chemical binding]; other site 649639011950 putative Mg++ binding site [ion binding]; other site 649639011951 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 649639011952 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 649639011953 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 649639011954 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 649639011955 HsdM N-terminal domain; Region: HsdM_N; pfam12161 649639011956 Methyltransferase domain; Region: Methyltransf_26; pfam13659 649639011957 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 649639011958 HsdM N-terminal domain; Region: HsdM_N; pfam12161 649639011959 Methyltransferase domain; Region: Methyltransf_26; pfam13659 649639011960 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 649639011961 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 649639011962 active site 649639011963 DNA binding site [nucleotide binding] 649639011964 Int/Topo IB signature motif; other site 649639011965 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 649639011966 Predicted ATPase [General function prediction only]; Region: COG5293 649639011967 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 649639011968 Uncharacterized N-terminal domain of the transcription elongation factor GreA [Function unknown]; Region: COG1747 649639011969 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 649639011970 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 649639011971 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 649639011972 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 649639011973 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 649639011974 YycH protein; Region: YycI; pfam09648 649639011975 YycH protein; Region: YycH; pfam07435 649639011976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 649639011977 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 649639011978 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649639011979 dimerization interface [polypeptide binding]; other site 649639011980 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649639011981 putative active site [active] 649639011982 heme pocket [chemical binding]; other site 649639011983 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649639011984 dimer interface [polypeptide binding]; other site 649639011985 phosphorylation site [posttranslational modification] 649639011986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649639011987 ATP binding site [chemical binding]; other site 649639011988 Mg2+ binding site [ion binding]; other site 649639011989 G-X-G motif; other site 649639011990 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649639011991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649639011992 active site 649639011993 phosphorylation site [posttranslational modification] 649639011994 intermolecular recognition site; other site 649639011995 dimerization interface [polypeptide binding]; other site 649639011996 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649639011997 DNA binding site [nucleotide binding] 649639011998 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 649639011999 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649639012000 G5 domain; Region: G5; pfam07501 649639012001 Peptidase family M23; Region: Peptidase_M23; pfam01551 649639012002 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 649639012003 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 649639012004 GDP-binding site [chemical binding]; other site 649639012005 ACT binding site; other site 649639012006 IMP binding site; other site 649639012007 replicative DNA helicase; Provisional; Region: PRK05748 649639012008 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 649639012009 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 649639012010 Walker A motif; other site 649639012011 ATP binding site [chemical binding]; other site 649639012012 Walker B motif; other site 649639012013 DNA binding loops [nucleotide binding] 649639012014 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 649639012015 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 649639012016 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 649639012017 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 649639012018 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 649639012019 DHH family; Region: DHH; pfam01368 649639012020 DHHA1 domain; Region: DHHA1; pfam02272 649639012021 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 649639012022 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 649639012023 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 649639012024 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 649639012025 dimer interface [polypeptide binding]; other site 649639012026 ssDNA binding site [nucleotide binding]; other site 649639012027 tetramer (dimer of dimers) interface [polypeptide binding]; other site 649639012028 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 649639012029 GTP-binding protein YchF; Reviewed; Region: PRK09601 649639012030 YchF GTPase; Region: YchF; cd01900 649639012031 G1 box; other site 649639012032 GTP/Mg2+ binding site [chemical binding]; other site 649639012033 Switch I region; other site 649639012034 G2 box; other site 649639012035 Switch II region; other site 649639012036 G3 box; other site 649639012037 G4 box; other site 649639012038 G5 box; other site 649639012039 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 649639012040 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 649639012041 Uncharacterized membrane protein [Function unknown]; Region: COG3949 649639012042 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 649639012043 Protein of unknown function (DUF554); Region: DUF554; pfam04474 649639012044 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 649639012045 ParB-like nuclease domain; Region: ParB; smart00470 649639012046 KorB domain; Region: KorB; pfam08535 649639012047 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 649639012048 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 649639012049 P-loop; other site 649639012050 Magnesium ion binding site [ion binding]; other site 649639012051 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 649639012052 Magnesium ion binding site [ion binding]; other site 649639012053 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 649639012054 ParB-like nuclease domain; Region: ParBc; pfam02195 649639012055 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 649639012056 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 649639012057 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 649639012058 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 649639012059 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 649639012060 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 649639012061 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 649639012062 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 649639012063 trmE is a tRNA modification GTPase; Region: trmE; cd04164 649639012064 G1 box; other site 649639012065 GTP/Mg2+ binding site [chemical binding]; other site 649639012066 Switch I region; other site 649639012067 G2 box; other site 649639012068 Switch II region; other site 649639012069 G3 box; other site 649639012070 G4 box; other site 649639012071 G5 box; other site 649639012072 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 649639012073 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 649639012074 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 649639012075 G-X-X-G motif; other site 649639012076 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 649639012077 RxxxH motif; other site 649639012078 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 649639012079 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 649639012080 Haemolytic domain; Region: Haemolytic; pfam01809 649639012081 ribonuclease P; Reviewed; Region: rnpA; PRK00499 649639012082 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399