-- dump date 20140618_214036 -- class Genbank::misc_feature -- table misc_feature_note -- id note 572264000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 572264000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 572264000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264000004 Walker A motif; other site 572264000005 ATP binding site [chemical binding]; other site 572264000006 Walker B motif; other site 572264000007 arginine finger; other site 572264000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 572264000009 DnaA box-binding interface [nucleotide binding]; other site 572264000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 572264000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 572264000012 putative DNA binding surface [nucleotide binding]; other site 572264000013 dimer interface [polypeptide binding]; other site 572264000014 beta-clamp/clamp loader binding surface; other site 572264000015 beta-clamp/translesion DNA polymerase binding surface; other site 572264000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 572264000017 recombination protein F; Reviewed; Region: recF; PRK00064 572264000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 572264000019 Walker A/P-loop; other site 572264000020 ATP binding site [chemical binding]; other site 572264000021 Q-loop/lid; other site 572264000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264000023 ABC transporter signature motif; other site 572264000024 Walker B; other site 572264000025 D-loop; other site 572264000026 H-loop/switch region; other site 572264000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 572264000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264000029 Mg2+ binding site [ion binding]; other site 572264000030 G-X-G motif; other site 572264000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 572264000032 anchoring element; other site 572264000033 dimer interface [polypeptide binding]; other site 572264000034 ATP binding site [chemical binding]; other site 572264000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 572264000036 active site 572264000037 putative metal-binding site [ion binding]; other site 572264000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 572264000039 DNA gyrase subunit A; Validated; Region: PRK05560 572264000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 572264000041 CAP-like domain; other site 572264000042 active site 572264000043 primary dimer interface [polypeptide binding]; other site 572264000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572264000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572264000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572264000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572264000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572264000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572264000050 YaaC-like Protein; Region: YaaC; pfam14175 572264000051 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 572264000052 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 572264000053 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 572264000054 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 572264000055 active site 572264000056 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 572264000057 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 572264000058 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 572264000059 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 572264000060 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 572264000061 active site 572264000062 multimer interface [polypeptide binding]; other site 572264000063 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 572264000064 predicted active site [active] 572264000065 catalytic triad [active] 572264000066 seryl-tRNA synthetase; Provisional; Region: PRK05431 572264000067 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 572264000068 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 572264000069 dimer interface [polypeptide binding]; other site 572264000070 active site 572264000071 motif 1; other site 572264000072 motif 2; other site 572264000073 motif 3; other site 572264000074 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 572264000075 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 572264000076 DNA binding residues [nucleotide binding] 572264000077 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 572264000078 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 572264000079 Substrate-binding site [chemical binding]; other site 572264000080 Substrate specificity [chemical binding]; other site 572264000081 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 572264000082 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 572264000083 Substrate-binding site [chemical binding]; other site 572264000084 Substrate specificity [chemical binding]; other site 572264000085 Isochorismatase family; Region: Isochorismatase; pfam00857 572264000086 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 572264000087 catalytic triad [active] 572264000088 conserved cis-peptide bond; other site 572264000089 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 572264000090 nucleoside/Zn binding site; other site 572264000091 dimer interface [polypeptide binding]; other site 572264000092 catalytic motif [active] 572264000093 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 572264000094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264000095 Walker A motif; other site 572264000096 ATP binding site [chemical binding]; other site 572264000097 Walker B motif; other site 572264000098 arginine finger; other site 572264000099 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 572264000100 hypothetical protein; Validated; Region: PRK00153 572264000101 recombination protein RecR; Reviewed; Region: recR; PRK00076 572264000102 RecR protein; Region: RecR; pfam02132 572264000103 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 572264000104 putative active site [active] 572264000105 putative metal-binding site [ion binding]; other site 572264000106 tetramer interface [polypeptide binding]; other site 572264000107 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 572264000108 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 572264000109 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 572264000110 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 572264000111 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 572264000112 homodimer interface [polypeptide binding]; other site 572264000113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264000114 catalytic residue [active] 572264000115 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 572264000116 thymidylate kinase; Validated; Region: tmk; PRK00698 572264000117 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 572264000118 TMP-binding site; other site 572264000119 ATP-binding site [chemical binding]; other site 572264000120 DNA polymerase III subunit delta'; Validated; Region: PRK08058 572264000121 DNA polymerase III subunit delta'; Validated; Region: PRK08485 572264000122 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 572264000123 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 572264000124 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 572264000125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264000126 S-adenosylmethionine binding site [chemical binding]; other site 572264000127 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 572264000128 catalytic site [active] 572264000129 metal binding site [ion binding]; metal-binding site 572264000130 Predicted methyltransferases [General function prediction only]; Region: COG0313 572264000131 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 572264000132 putative SAM binding site [chemical binding]; other site 572264000133 putative homodimer interface [polypeptide binding]; other site 572264000134 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 572264000135 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 572264000136 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 572264000137 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 572264000138 active site 572264000139 HIGH motif; other site 572264000140 KMSKS motif; other site 572264000141 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 572264000142 tRNA binding surface [nucleotide binding]; other site 572264000143 anticodon binding site; other site 572264000144 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 572264000145 dimer interface [polypeptide binding]; other site 572264000146 putative tRNA-binding site [nucleotide binding]; other site 572264000147 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 572264000148 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 572264000149 active site 572264000150 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 572264000151 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 572264000152 putative active site [active] 572264000153 putative metal binding site [ion binding]; other site 572264000154 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 572264000155 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 572264000156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264000157 S-adenosylmethionine binding site [chemical binding]; other site 572264000158 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 572264000159 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 572264000160 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 572264000161 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 572264000162 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 572264000163 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 572264000164 pur operon repressor; Provisional; Region: PRK09213 572264000165 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 572264000166 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572264000167 active site 572264000168 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 572264000169 homotrimer interaction site [polypeptide binding]; other site 572264000170 putative active site [active] 572264000171 regulatory protein SpoVG; Reviewed; Region: PRK13259 572264000172 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 572264000173 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 572264000174 Substrate binding site; other site 572264000175 Mg++ binding site; other site 572264000176 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 572264000177 active site 572264000178 substrate binding site [chemical binding]; other site 572264000179 CoA binding site [chemical binding]; other site 572264000180 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 572264000181 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 572264000182 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572264000183 active site 572264000184 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 572264000185 putative active site [active] 572264000186 catalytic residue [active] 572264000187 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 572264000188 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 572264000189 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 572264000190 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572264000191 ATP binding site [chemical binding]; other site 572264000192 putative Mg++ binding site [ion binding]; other site 572264000193 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572264000194 nucleotide binding region [chemical binding]; other site 572264000195 ATP-binding site [chemical binding]; other site 572264000196 TRCF domain; Region: TRCF; pfam03461 572264000197 stage V sporulation protein T; Region: spore_V_T; TIGR02851 572264000198 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 572264000199 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 572264000200 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 572264000201 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 572264000202 putative SAM binding site [chemical binding]; other site 572264000203 putative homodimer interface [polypeptide binding]; other site 572264000204 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 572264000205 homodimer interface [polypeptide binding]; other site 572264000206 metal binding site [ion binding]; metal-binding site 572264000207 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 572264000208 homodimer interface [polypeptide binding]; other site 572264000209 active site 572264000210 putative chemical substrate binding site [chemical binding]; other site 572264000211 metal binding site [ion binding]; metal-binding site 572264000212 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572264000213 RNA binding surface [nucleotide binding]; other site 572264000214 sporulation protein YabP; Region: spore_yabP; TIGR02892 572264000215 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 572264000216 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 572264000217 Septum formation initiator; Region: DivIC; pfam04977 572264000218 hypothetical protein; Provisional; Region: PRK08582 572264000219 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 572264000220 RNA binding site [nucleotide binding]; other site 572264000221 stage II sporulation protein E; Region: spore_II_E; TIGR02865 572264000222 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 572264000223 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 572264000224 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 572264000225 Ligand Binding Site [chemical binding]; other site 572264000226 TilS substrate binding domain; Region: TilS; pfam09179 572264000227 TilS substrate C-terminal domain; Region: TilS_C; smart00977 572264000228 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572264000229 active site 572264000230 FtsH Extracellular; Region: FtsH_ext; pfam06480 572264000231 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 572264000232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264000233 Walker A motif; other site 572264000234 ATP binding site [chemical binding]; other site 572264000235 Walker B motif; other site 572264000236 arginine finger; other site 572264000237 Peptidase family M41; Region: Peptidase_M41; pfam01434 572264000238 pantothenate kinase; Reviewed; Region: PRK13318 572264000239 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 572264000240 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 572264000241 dimerization interface [polypeptide binding]; other site 572264000242 domain crossover interface; other site 572264000243 redox-dependent activation switch; other site 572264000244 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 572264000245 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 572264000246 dimer interface [polypeptide binding]; other site 572264000247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264000248 catalytic residue [active] 572264000249 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 572264000250 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 572264000251 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 572264000252 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 572264000253 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 572264000254 glutamine binding [chemical binding]; other site 572264000255 catalytic triad [active] 572264000256 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 572264000257 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 572264000258 homodimer interface [polypeptide binding]; other site 572264000259 substrate-cofactor binding pocket; other site 572264000260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264000261 catalytic residue [active] 572264000262 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 572264000263 dihydropteroate synthase; Region: DHPS; TIGR01496 572264000264 substrate binding pocket [chemical binding]; other site 572264000265 dimer interface [polypeptide binding]; other site 572264000266 inhibitor binding site; inhibition site 572264000267 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 572264000268 homooctamer interface [polypeptide binding]; other site 572264000269 active site 572264000270 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 572264000271 catalytic center binding site [active] 572264000272 ATP binding site [chemical binding]; other site 572264000273 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572264000274 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264000275 non-specific DNA binding site [nucleotide binding]; other site 572264000276 salt bridge; other site 572264000277 sequence-specific DNA binding site [nucleotide binding]; other site 572264000278 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 572264000279 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 572264000280 FMN binding site [chemical binding]; other site 572264000281 active site 572264000282 catalytic residues [active] 572264000283 substrate binding site [chemical binding]; other site 572264000284 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 572264000285 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 572264000286 dimer interface [polypeptide binding]; other site 572264000287 putative anticodon binding site; other site 572264000288 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 572264000289 motif 1; other site 572264000290 active site 572264000291 motif 2; other site 572264000292 motif 3; other site 572264000293 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 572264000294 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 572264000295 UvrB/uvrC motif; Region: UVR; pfam02151 572264000296 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 572264000297 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 572264000298 ADP binding site [chemical binding]; other site 572264000299 phosphagen binding site; other site 572264000300 substrate specificity loop; other site 572264000301 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 572264000302 Clp amino terminal domain; Region: Clp_N; pfam02861 572264000303 Clp amino terminal domain; Region: Clp_N; pfam02861 572264000304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264000305 Walker A motif; other site 572264000306 ATP binding site [chemical binding]; other site 572264000307 Walker B motif; other site 572264000308 arginine finger; other site 572264000309 UvrB/uvrC motif; Region: UVR; pfam02151 572264000310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264000311 Walker A motif; other site 572264000312 ATP binding site [chemical binding]; other site 572264000313 Walker B motif; other site 572264000314 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 572264000315 DNA repair protein RadA; Provisional; Region: PRK11823 572264000316 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 572264000317 Walker A motif/ATP binding site; other site 572264000318 ATP binding site [chemical binding]; other site 572264000319 Walker B motif; other site 572264000320 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 572264000321 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 572264000322 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 572264000323 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 572264000324 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 572264000325 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 572264000326 putative active site [active] 572264000327 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 572264000328 substrate binding site; other site 572264000329 dimer interface; other site 572264000330 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 572264000331 homotrimer interaction site [polypeptide binding]; other site 572264000332 zinc binding site [ion binding]; other site 572264000333 CDP-binding sites; other site 572264000334 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 572264000335 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 572264000336 active site 572264000337 HIGH motif; other site 572264000338 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 572264000339 active site 572264000340 KMSKS motif; other site 572264000341 serine O-acetyltransferase; Region: cysE; TIGR01172 572264000342 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 572264000343 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 572264000344 trimer interface [polypeptide binding]; other site 572264000345 active site 572264000346 substrate binding site [chemical binding]; other site 572264000347 CoA binding site [chemical binding]; other site 572264000348 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 572264000349 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 572264000350 active site 572264000351 HIGH motif; other site 572264000352 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 572264000353 KMSKS motif; other site 572264000354 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 572264000355 tRNA binding surface [nucleotide binding]; other site 572264000356 anticodon binding site; other site 572264000357 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 572264000358 active site 572264000359 metal binding site [ion binding]; metal-binding site 572264000360 dimerization interface [polypeptide binding]; other site 572264000361 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 572264000362 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 572264000363 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 572264000364 YacP-like NYN domain; Region: NYN_YacP; pfam05991 572264000365 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 572264000366 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264000367 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 572264000368 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 572264000369 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 572264000370 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 572264000371 putative homodimer interface [polypeptide binding]; other site 572264000372 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 572264000373 heterodimer interface [polypeptide binding]; other site 572264000374 homodimer interface [polypeptide binding]; other site 572264000375 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 572264000376 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 572264000377 23S rRNA interface [nucleotide binding]; other site 572264000378 L7/L12 interface [polypeptide binding]; other site 572264000379 putative thiostrepton binding site; other site 572264000380 L25 interface [polypeptide binding]; other site 572264000381 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 572264000382 mRNA/rRNA interface [nucleotide binding]; other site 572264000383 Ribosomal protein L10 leader 572264000384 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 572264000385 23S rRNA interface [nucleotide binding]; other site 572264000386 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 572264000387 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 572264000388 core dimer interface [polypeptide binding]; other site 572264000389 peripheral dimer interface [polypeptide binding]; other site 572264000390 L10 interface [polypeptide binding]; other site 572264000391 L11 interface [polypeptide binding]; other site 572264000392 putative EF-Tu interaction site [polypeptide binding]; other site 572264000393 putative EF-G interaction site [polypeptide binding]; other site 572264000394 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 572264000395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264000396 S-adenosylmethionine binding site [chemical binding]; other site 572264000397 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 572264000398 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 572264000399 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 572264000400 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 572264000401 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 572264000402 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 572264000403 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 572264000404 RPB10 interaction site [polypeptide binding]; other site 572264000405 RPB1 interaction site [polypeptide binding]; other site 572264000406 RPB11 interaction site [polypeptide binding]; other site 572264000407 RPB3 interaction site [polypeptide binding]; other site 572264000408 RPB12 interaction site [polypeptide binding]; other site 572264000409 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 572264000410 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 572264000411 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 572264000412 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 572264000413 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 572264000414 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 572264000415 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 572264000416 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 572264000417 G-loop; other site 572264000418 DNA binding site [nucleotide binding] 572264000419 hypothetical protein; Provisional; Region: PRK06683 572264000420 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 572264000421 S17 interaction site [polypeptide binding]; other site 572264000422 S8 interaction site; other site 572264000423 16S rRNA interaction site [nucleotide binding]; other site 572264000424 streptomycin interaction site [chemical binding]; other site 572264000425 23S rRNA interaction site [nucleotide binding]; other site 572264000426 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 572264000427 30S ribosomal protein S7; Validated; Region: PRK05302 572264000428 elongation factor G; Reviewed; Region: PRK00007 572264000429 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 572264000430 G1 box; other site 572264000431 putative GEF interaction site [polypeptide binding]; other site 572264000432 GTP/Mg2+ binding site [chemical binding]; other site 572264000433 Switch I region; other site 572264000434 G2 box; other site 572264000435 G3 box; other site 572264000436 Switch II region; other site 572264000437 G4 box; other site 572264000438 G5 box; other site 572264000439 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 572264000440 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 572264000441 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 572264000442 elongation factor Tu; Reviewed; Region: PRK00049 572264000443 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 572264000444 G1 box; other site 572264000445 GEF interaction site [polypeptide binding]; other site 572264000446 GTP/Mg2+ binding site [chemical binding]; other site 572264000447 Switch I region; other site 572264000448 G2 box; other site 572264000449 G3 box; other site 572264000450 Switch II region; other site 572264000451 G4 box; other site 572264000452 G5 box; other site 572264000453 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 572264000454 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 572264000455 Antibiotic Binding Site [chemical binding]; other site 572264000456 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 572264000457 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 572264000458 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 572264000459 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 572264000460 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 572264000461 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 572264000462 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 572264000463 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 572264000464 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 572264000465 putative translocon binding site; other site 572264000466 protein-rRNA interface [nucleotide binding]; other site 572264000467 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 572264000468 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 572264000469 G-X-X-G motif; other site 572264000470 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 572264000471 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 572264000472 23S rRNA interface [nucleotide binding]; other site 572264000473 5S rRNA interface [nucleotide binding]; other site 572264000474 putative antibiotic binding site [chemical binding]; other site 572264000475 L25 interface [polypeptide binding]; other site 572264000476 L27 interface [polypeptide binding]; other site 572264000477 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 572264000478 23S rRNA interface [nucleotide binding]; other site 572264000479 putative translocon interaction site; other site 572264000480 signal recognition particle (SRP54) interaction site; other site 572264000481 L23 interface [polypeptide binding]; other site 572264000482 trigger factor interaction site; other site 572264000483 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 572264000484 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 572264000485 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 572264000486 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 572264000487 RNA binding site [nucleotide binding]; other site 572264000488 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 572264000489 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 572264000490 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 572264000491 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 572264000492 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 572264000493 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 572264000494 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 572264000495 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 572264000496 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 572264000497 5S rRNA interface [nucleotide binding]; other site 572264000498 L27 interface [polypeptide binding]; other site 572264000499 23S rRNA interface [nucleotide binding]; other site 572264000500 L5 interface [polypeptide binding]; other site 572264000501 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 572264000502 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 572264000503 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 572264000504 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 572264000505 23S rRNA binding site [nucleotide binding]; other site 572264000506 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 572264000507 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 572264000508 SecY translocase; Region: SecY; pfam00344 572264000509 adenylate kinase; Reviewed; Region: adk; PRK00279 572264000510 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 572264000511 AMP-binding site [chemical binding]; other site 572264000512 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 572264000513 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 572264000514 active site 572264000515 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 572264000516 rRNA binding site [nucleotide binding]; other site 572264000517 predicted 30S ribosome binding site; other site 572264000518 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 572264000519 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 572264000520 30S ribosomal protein S13; Region: bact_S13; TIGR03631 572264000521 30S ribosomal protein S11; Validated; Region: PRK05309 572264000522 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 572264000523 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 572264000524 alphaNTD - beta interaction site [polypeptide binding]; other site 572264000525 alphaNTD homodimer interface [polypeptide binding]; other site 572264000526 alphaNTD - beta' interaction site [polypeptide binding]; other site 572264000527 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 572264000528 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 572264000529 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 572264000530 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 572264000531 Walker A/P-loop; other site 572264000532 ATP binding site [chemical binding]; other site 572264000533 Q-loop/lid; other site 572264000534 ABC transporter signature motif; other site 572264000535 Walker B; other site 572264000536 D-loop; other site 572264000537 H-loop/switch region; other site 572264000538 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 572264000539 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 572264000540 Walker A/P-loop; other site 572264000541 ATP binding site [chemical binding]; other site 572264000542 Q-loop/lid; other site 572264000543 ABC transporter signature motif; other site 572264000544 Walker B; other site 572264000545 D-loop; other site 572264000546 H-loop/switch region; other site 572264000547 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 572264000548 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 572264000549 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 572264000550 dimerization interface 3.5A [polypeptide binding]; other site 572264000551 active site 572264000552 Ribosomal protein L13 leader 572264000553 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 572264000554 23S rRNA interface [nucleotide binding]; other site 572264000555 L3 interface [polypeptide binding]; other site 572264000556 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 572264000557 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 572264000558 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 572264000559 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 572264000560 active site 572264000561 metal binding site [ion binding]; metal-binding site 572264000562 Domain of unknown function DUF59; Region: DUF59; pfam01883 572264000563 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 572264000564 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 572264000565 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 572264000566 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 572264000567 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 572264000568 NodB motif; other site 572264000569 putative active site [active] 572264000570 putative catalytic site [active] 572264000571 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 572264000572 Arginase family; Region: Arginase; cd09989 572264000573 agmatinase; Region: agmatinase; TIGR01230 572264000574 active site 572264000575 Mn binding site [ion binding]; other site 572264000576 oligomer interface [polypeptide binding]; other site 572264000577 Uncharacterized conserved protein [Function unknown]; Region: COG1624 572264000578 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 572264000579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 572264000580 YbbR-like protein; Region: YbbR; pfam07949 572264000581 YbbR-like protein; Region: YbbR; pfam07949 572264000582 YbbR-like protein; Region: YbbR; pfam07949 572264000583 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 572264000584 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 572264000585 active site 572264000586 substrate binding site [chemical binding]; other site 572264000587 metal binding site [ion binding]; metal-binding site 572264000588 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 572264000589 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 572264000590 glutaminase active site [active] 572264000591 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 572264000592 dimer interface [polypeptide binding]; other site 572264000593 active site 572264000594 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 572264000595 dimer interface [polypeptide binding]; other site 572264000596 active site 572264000597 Transcriptional regulators [Transcription]; Region: GntR; COG1802 572264000598 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572264000599 DNA-binding site [nucleotide binding]; DNA binding site 572264000600 FCD domain; Region: FCD; pfam07729 572264000601 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 572264000602 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 572264000603 N- and C-terminal domain interface [polypeptide binding]; other site 572264000604 active site 572264000605 catalytic site [active] 572264000606 metal binding site [ion binding]; metal-binding site 572264000607 carbohydrate binding site [chemical binding]; other site 572264000608 ATP binding site [chemical binding]; other site 572264000609 fructuronate transporter; Provisional; Region: PRK10034; cl15264 572264000610 gluconate transporter; Region: gntP; TIGR00791 572264000611 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 572264000612 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 572264000613 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 572264000614 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 572264000615 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 572264000616 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 572264000617 DoxX; Region: DoxX; cl17842 572264000618 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 572264000619 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 572264000620 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 572264000621 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264000622 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572264000623 DNA binding residues [nucleotide binding] 572264000624 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 572264000625 classical (c) SDRs; Region: SDR_c; cd05233 572264000626 NAD(P) binding site [chemical binding]; other site 572264000627 active site 572264000628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264000629 ABC-ATPase subunit interface; other site 572264000630 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 572264000631 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 572264000632 Walker A/P-loop; other site 572264000633 ATP binding site [chemical binding]; other site 572264000634 Q-loop/lid; other site 572264000635 ABC transporter signature motif; other site 572264000636 Walker B; other site 572264000637 D-loop; other site 572264000638 H-loop/switch region; other site 572264000639 NIL domain; Region: NIL; pfam09383 572264000640 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 572264000641 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 572264000642 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 572264000643 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 572264000644 putative NAD(P) binding site [chemical binding]; other site 572264000645 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 572264000646 FAD binding domain; Region: FAD_binding_4; pfam01565 572264000647 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264000648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264000649 putative substrate translocation pore; other site 572264000650 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 572264000651 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 572264000652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264000653 putative substrate translocation pore; other site 572264000654 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 572264000655 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 572264000656 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 572264000657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264000658 dimer interface [polypeptide binding]; other site 572264000659 conserved gate region; other site 572264000660 putative PBP binding loops; other site 572264000661 ABC-ATPase subunit interface; other site 572264000662 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 572264000663 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 572264000664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264000665 dimer interface [polypeptide binding]; other site 572264000666 conserved gate region; other site 572264000667 putative PBP binding loops; other site 572264000668 ABC-ATPase subunit interface; other site 572264000669 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 572264000670 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572264000671 Walker A/P-loop; other site 572264000672 ATP binding site [chemical binding]; other site 572264000673 Q-loop/lid; other site 572264000674 ABC transporter signature motif; other site 572264000675 Walker B; other site 572264000676 D-loop; other site 572264000677 H-loop/switch region; other site 572264000678 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 572264000679 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 572264000680 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572264000681 Walker A/P-loop; other site 572264000682 ATP binding site [chemical binding]; other site 572264000683 Q-loop/lid; other site 572264000684 ABC transporter signature motif; other site 572264000685 Walker B; other site 572264000686 D-loop; other site 572264000687 H-loop/switch region; other site 572264000688 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 572264000689 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 572264000690 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 572264000691 peptide binding site [polypeptide binding]; other site 572264000692 YusW-like protein; Region: YusW; pfam14039 572264000693 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 572264000694 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 572264000695 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 572264000696 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264000697 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264000698 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 572264000699 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 572264000700 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 572264000701 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 572264000702 peptide binding site [polypeptide binding]; other site 572264000703 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 572264000704 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 572264000705 peptide binding site [polypeptide binding]; other site 572264000706 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 572264000707 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 572264000708 active site 572264000709 catalytic tetrad [active] 572264000710 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 572264000711 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 572264000712 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 572264000713 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 572264000714 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 572264000715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264000716 dimer interface [polypeptide binding]; other site 572264000717 conserved gate region; other site 572264000718 putative PBP binding loops; other site 572264000719 ABC-ATPase subunit interface; other site 572264000720 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 572264000721 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 572264000722 dimerization interface [polypeptide binding]; other site 572264000723 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572264000724 membrane-bound complex binding site; other site 572264000725 hinge residues; other site 572264000726 DNA binding domain, excisionase family; Region: excise; TIGR01764 572264000727 PBP superfamily domain; Region: PBP_like; pfam12727 572264000728 Transcriptional regulator [Transcription]; Region: LysR; COG0583 572264000729 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572264000730 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 572264000731 putative dimerization interface [polypeptide binding]; other site 572264000732 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 572264000733 EamA-like transporter family; Region: EamA; pfam00892 572264000734 YrzO-like protein; Region: YrzO; pfam14142 572264000735 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 572264000736 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 572264000737 putative acyl-acceptor binding pocket; other site 572264000738 Transcriptional regulators [Transcription]; Region: PurR; COG1609 572264000739 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 572264000740 DNA binding site [nucleotide binding] 572264000741 domain linker motif; other site 572264000742 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 572264000743 putative ligand binding site [chemical binding]; other site 572264000744 putative dimerization interface [polypeptide binding]; other site 572264000745 Uncharacterized conserved protein [Function unknown]; Region: COG1284 572264000746 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 572264000747 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 572264000748 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 572264000749 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 572264000750 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 572264000751 active site 572264000752 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 572264000753 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 572264000754 C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441 572264000755 lysozyme catalytic site [active] 572264000756 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 572264000757 nucleotide binding site/active site [active] 572264000758 HIT family signature motif; other site 572264000759 catalytic residue [active] 572264000760 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 572264000761 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264000762 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264000763 ABC transporter; Region: ABC_tran_2; pfam12848 572264000764 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264000765 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 572264000766 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 572264000767 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 572264000768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264000769 dimer interface [polypeptide binding]; other site 572264000770 conserved gate region; other site 572264000771 putative PBP binding loops; other site 572264000772 ABC-ATPase subunit interface; other site 572264000773 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 572264000774 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 572264000775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264000776 dimer interface [polypeptide binding]; other site 572264000777 conserved gate region; other site 572264000778 putative PBP binding loops; other site 572264000779 ABC-ATPase subunit interface; other site 572264000780 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 572264000781 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572264000782 Walker A/P-loop; other site 572264000783 ATP binding site [chemical binding]; other site 572264000784 Q-loop/lid; other site 572264000785 ABC transporter signature motif; other site 572264000786 Walker B; other site 572264000787 D-loop; other site 572264000788 H-loop/switch region; other site 572264000789 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 572264000790 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 572264000791 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572264000792 Walker A/P-loop; other site 572264000793 ATP binding site [chemical binding]; other site 572264000794 Q-loop/lid; other site 572264000795 ABC transporter signature motif; other site 572264000796 Walker B; other site 572264000797 D-loop; other site 572264000798 H-loop/switch region; other site 572264000799 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 572264000800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264000801 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 572264000802 active site 572264000803 motif I; other site 572264000804 motif II; other site 572264000805 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264000806 motif II; other site 572264000807 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 572264000808 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 572264000809 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 572264000810 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 572264000811 dimer interface [polypeptide binding]; other site 572264000812 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 572264000813 active site 572264000814 Fe binding site [ion binding]; other site 572264000815 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 572264000816 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 572264000817 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 572264000818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264000819 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264000820 putative substrate translocation pore; other site 572264000821 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 572264000822 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 572264000823 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 572264000824 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 572264000825 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 572264000826 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 572264000827 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 572264000828 helicase 45; Provisional; Region: PTZ00424 572264000829 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 572264000830 ATP binding site [chemical binding]; other site 572264000831 Mg++ binding site [ion binding]; other site 572264000832 motif III; other site 572264000833 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572264000834 nucleotide binding region [chemical binding]; other site 572264000835 ATP-binding site [chemical binding]; other site 572264000836 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 572264000837 Rhomboid family; Region: Rhomboid; pfam01694 572264000838 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 572264000839 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 572264000840 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 572264000841 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 572264000842 alanine racemase; Reviewed; Region: alr; PRK00053 572264000843 active site 572264000844 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 572264000845 dimer interface [polypeptide binding]; other site 572264000846 substrate binding site [chemical binding]; other site 572264000847 catalytic residues [active] 572264000848 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 572264000849 PemK-like protein; Region: PemK; pfam02452 572264000850 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 572264000851 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 572264000852 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 572264000853 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 572264000854 RNA binding site [nucleotide binding]; other site 572264000855 hypothetical protein; Provisional; Region: PRK04351 572264000856 SprT homologues; Region: SprT; cl01182 572264000857 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 572264000858 Glycoprotease family; Region: Peptidase_M22; pfam00814 572264000859 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 572264000860 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 572264000861 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264000862 Coenzyme A binding pocket [chemical binding]; other site 572264000863 UGMP family protein; Validated; Region: PRK09604 572264000864 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 572264000865 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 572264000866 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 572264000867 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264000868 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264000869 ABC transporter; Region: ABC_tran_2; pfam12848 572264000870 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264000871 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 572264000872 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 572264000873 CoA binding domain; Region: CoA_binding; pfam02629 572264000874 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 572264000875 CAAX protease self-immunity; Region: Abi; pfam02517 572264000876 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 572264000877 oligomerisation interface [polypeptide binding]; other site 572264000878 mobile loop; other site 572264000879 roof hairpin; other site 572264000880 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 572264000881 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 572264000882 ring oligomerisation interface [polypeptide binding]; other site 572264000883 ATP/Mg binding site [chemical binding]; other site 572264000884 stacking interactions; other site 572264000885 hinge regions; other site 572264000886 Uncharacterized conserved protein [Function unknown]; Region: COG5444 572264000887 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 572264000888 GMP synthase; Reviewed; Region: guaA; PRK00074 572264000889 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 572264000890 AMP/PPi binding site [chemical binding]; other site 572264000891 candidate oxyanion hole; other site 572264000892 catalytic triad [active] 572264000893 potential glutamine specificity residues [chemical binding]; other site 572264000894 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 572264000895 ATP Binding subdomain [chemical binding]; other site 572264000896 Ligand Binding sites [chemical binding]; other site 572264000897 Dimerization subdomain; other site 572264000898 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 572264000899 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264000900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264000901 active site 572264000902 phosphorylation site [posttranslational modification] 572264000903 intermolecular recognition site; other site 572264000904 dimerization interface [polypeptide binding]; other site 572264000905 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264000906 DNA binding site [nucleotide binding] 572264000907 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264000908 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264000909 dimerization interface [polypeptide binding]; other site 572264000910 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264000911 dimer interface [polypeptide binding]; other site 572264000912 phosphorylation site [posttranslational modification] 572264000913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264000914 ATP binding site [chemical binding]; other site 572264000915 Mg2+ binding site [ion binding]; other site 572264000916 G-X-G motif; other site 572264000917 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 572264000918 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 572264000919 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 572264000920 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 572264000921 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 572264000922 catalytic residues [active] 572264000923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572264000924 NAD(P) binding site [chemical binding]; other site 572264000925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572264000926 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 572264000927 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 572264000928 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 572264000929 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 572264000930 Walker A/P-loop; other site 572264000931 ATP binding site [chemical binding]; other site 572264000932 Q-loop/lid; other site 572264000933 ABC transporter signature motif; other site 572264000934 Walker B; other site 572264000935 D-loop; other site 572264000936 H-loop/switch region; other site 572264000937 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264000938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264000939 dimer interface [polypeptide binding]; other site 572264000940 phosphorylation site [posttranslational modification] 572264000941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264000942 ATP binding site [chemical binding]; other site 572264000943 Mg2+ binding site [ion binding]; other site 572264000944 G-X-G motif; other site 572264000945 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264000946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264000947 active site 572264000948 phosphorylation site [posttranslational modification] 572264000949 intermolecular recognition site; other site 572264000950 dimerization interface [polypeptide binding]; other site 572264000951 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264000952 DNA binding site [nucleotide binding] 572264000953 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 572264000954 EamA-like transporter family; Region: EamA; pfam00892 572264000955 EamA-like transporter family; Region: EamA; pfam00892 572264000956 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 572264000957 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 572264000958 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 572264000959 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 572264000960 NAD binding site [chemical binding]; other site 572264000961 ATP-grasp domain; Region: ATP-grasp; pfam02222 572264000962 adenylosuccinate lyase; Provisional; Region: PRK07492 572264000963 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 572264000964 tetramer interface [polypeptide binding]; other site 572264000965 active site 572264000966 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 572264000967 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 572264000968 ATP binding site [chemical binding]; other site 572264000969 active site 572264000970 substrate binding site [chemical binding]; other site 572264000971 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 572264000972 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 572264000973 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 572264000974 putative active site [active] 572264000975 catalytic triad [active] 572264000976 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 572264000977 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 572264000978 dimerization interface [polypeptide binding]; other site 572264000979 ATP binding site [chemical binding]; other site 572264000980 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 572264000981 dimerization interface [polypeptide binding]; other site 572264000982 ATP binding site [chemical binding]; other site 572264000983 amidophosphoribosyltransferase; Provisional; Region: PRK06781 572264000984 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 572264000985 active site 572264000986 tetramer interface [polypeptide binding]; other site 572264000987 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572264000988 active site 572264000989 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 572264000990 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 572264000991 dimerization interface [polypeptide binding]; other site 572264000992 putative ATP binding site [chemical binding]; other site 572264000993 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 572264000994 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 572264000995 active site 572264000996 substrate binding site [chemical binding]; other site 572264000997 cosubstrate binding site; other site 572264000998 catalytic site [active] 572264000999 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 572264001000 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 572264001001 purine monophosphate binding site [chemical binding]; other site 572264001002 dimer interface [polypeptide binding]; other site 572264001003 putative catalytic residues [active] 572264001004 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 572264001005 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 572264001006 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 572264001007 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 572264001008 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 572264001009 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 572264001010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 572264001011 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 572264001012 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 572264001013 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 572264001014 PcrB family; Region: PcrB; pfam01884 572264001015 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 572264001016 substrate binding site [chemical binding]; other site 572264001017 putative active site [active] 572264001018 dimer interface [polypeptide binding]; other site 572264001019 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 572264001020 Part of AAA domain; Region: AAA_19; pfam13245 572264001021 Family description; Region: UvrD_C_2; pfam13538 572264001022 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 572264001023 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 572264001024 nucleotide binding pocket [chemical binding]; other site 572264001025 K-X-D-G motif; other site 572264001026 catalytic site [active] 572264001027 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 572264001028 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 572264001029 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 572264001030 Dimer interface [polypeptide binding]; other site 572264001031 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 572264001032 putative dimer interface [polypeptide binding]; other site 572264001033 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 572264001034 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 572264001035 putative dimer interface [polypeptide binding]; other site 572264001036 hypothetical protein; Provisional; Region: PRK10621 572264001037 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 572264001038 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 572264001039 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 572264001040 Glutamate binding site [chemical binding]; other site 572264001041 homodimer interface [polypeptide binding]; other site 572264001042 NAD binding site [chemical binding]; other site 572264001043 catalytic residues [active] 572264001044 Isochorismatase family; Region: Isochorismatase; pfam00857 572264001045 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 572264001046 catalytic triad [active] 572264001047 conserved cis-peptide bond; other site 572264001048 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 572264001049 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 572264001050 Walker A/P-loop; other site 572264001051 ATP binding site [chemical binding]; other site 572264001052 Q-loop/lid; other site 572264001053 ABC transporter signature motif; other site 572264001054 Walker B; other site 572264001055 D-loop; other site 572264001056 H-loop/switch region; other site 572264001057 NIL domain; Region: NIL; pfam09383 572264001058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264001059 dimer interface [polypeptide binding]; other site 572264001060 conserved gate region; other site 572264001061 ABC-ATPase subunit interface; other site 572264001062 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 572264001063 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 572264001064 Protein of unknown function (DUF3926); Region: DUF3926; pfam13080 572264001065 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 572264001066 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 572264001067 P loop; other site 572264001068 Nucleotide binding site [chemical binding]; other site 572264001069 DTAP/Switch II; other site 572264001070 Switch I; other site 572264001071 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 572264001072 putative dimer interface [polypeptide binding]; other site 572264001073 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 572264001074 MarR family; Region: MarR; pfam01047 572264001075 MarR family; Region: MarR_2; cl17246 572264001076 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 572264001077 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 572264001078 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 572264001079 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 572264001080 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 572264001081 GatB domain; Region: GatB_Yqey; pfam02637 572264001082 putative lipid kinase; Reviewed; Region: PRK13337 572264001083 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 572264001084 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 572264001085 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264001086 motif II; other site 572264001087 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 572264001088 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 572264001089 inhibitor-cofactor binding pocket; inhibition site 572264001090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264001091 catalytic residue [active] 572264001092 PAS domain; Region: PAS_9; pfam13426 572264001093 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572264001094 putative active site [active] 572264001095 heme pocket [chemical binding]; other site 572264001096 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 572264001097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264001098 Walker A motif; other site 572264001099 ATP binding site [chemical binding]; other site 572264001100 Walker B motif; other site 572264001101 arginine finger; other site 572264001102 succinic semialdehyde dehydrogenase; Region: PLN02278 572264001103 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 572264001104 tetramerization interface [polypeptide binding]; other site 572264001105 NAD(P) binding site [chemical binding]; other site 572264001106 catalytic residues [active] 572264001107 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 572264001108 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 572264001109 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 572264001110 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 572264001111 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 572264001112 putative active site [active] 572264001113 putative metal binding site [ion binding]; other site 572264001114 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 572264001115 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 572264001116 putative active site [active] 572264001117 putative metal binding site [ion binding]; other site 572264001118 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 572264001119 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 572264001120 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 572264001121 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 572264001122 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 572264001123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264001124 S-adenosylmethionine binding site [chemical binding]; other site 572264001125 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 572264001126 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 572264001127 FMN binding site [chemical binding]; other site 572264001128 active site 572264001129 catalytic residues [active] 572264001130 substrate binding site [chemical binding]; other site 572264001131 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 572264001132 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 572264001133 GAF domain; Region: GAF_2; pfam13185 572264001134 GAF domain; Region: GAF_3; pfam13492 572264001135 PAS fold; Region: PAS_4; pfam08448 572264001136 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264001137 dimer interface [polypeptide binding]; other site 572264001138 phosphorylation site [posttranslational modification] 572264001139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264001140 ATP binding site [chemical binding]; other site 572264001141 Mg2+ binding site [ion binding]; other site 572264001142 G-X-G motif; other site 572264001143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 572264001144 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 572264001145 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 572264001146 Protein of unknown function DUF45; Region: DUF45; pfam01863 572264001147 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 572264001148 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 572264001149 active site 572264001150 Predicted transcriptional regulator [Transcription]; Region: COG3355 572264001151 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 572264001152 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 572264001153 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 572264001154 metal binding site [ion binding]; metal-binding site 572264001155 putative dimer interface [polypeptide binding]; other site 572264001156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264001157 S-adenosylmethionine binding site [chemical binding]; other site 572264001158 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 572264001159 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 572264001160 catalytic residue [active] 572264001161 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 572264001162 catalytic residues [active] 572264001163 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572264001164 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572264001165 peroxiredoxin; Region: AhpC; TIGR03137 572264001166 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 572264001167 dimer interface [polypeptide binding]; other site 572264001168 decamer (pentamer of dimers) interface [polypeptide binding]; other site 572264001169 catalytic triad [active] 572264001170 peroxidatic and resolving cysteines [active] 572264001171 5-methylribose kinase; Reviewed; Region: PRK12396 572264001172 Phosphotransferase enzyme family; Region: APH; pfam01636 572264001173 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 572264001174 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 572264001175 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 572264001176 intersubunit interface [polypeptide binding]; other site 572264001177 active site 572264001178 Zn2+ binding site [ion binding]; other site 572264001179 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 572264001180 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572264001181 ABC-ATPase subunit interface; other site 572264001182 dimer interface [polypeptide binding]; other site 572264001183 putative PBP binding regions; other site 572264001184 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 572264001185 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572264001186 ABC-ATPase subunit interface; other site 572264001187 dimer interface [polypeptide binding]; other site 572264001188 putative PBP binding regions; other site 572264001189 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 572264001190 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 572264001191 putative ligand binding residues [chemical binding]; other site 572264001192 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 572264001193 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572264001194 DNA binding domain, excisionase family; Region: excise; TIGR01764 572264001195 Sm and related proteins; Region: Sm_like; cl00259 572264001196 Sm1 motif; other site 572264001197 RNA binding site [nucleotide binding]; other site 572264001198 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 572264001199 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 572264001200 hypothetical protein; Provisional; Region: PRK06851 572264001201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 572264001202 Walker A motif; other site 572264001203 ATP binding site [chemical binding]; other site 572264001204 NTPase; Region: NTPase_1; cl17478 572264001205 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 572264001206 benzoate transport; Region: 2A0115; TIGR00895 572264001207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264001208 putative substrate translocation pore; other site 572264001209 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 572264001210 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 572264001211 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 572264001212 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 572264001213 [2Fe-2S] cluster binding site [ion binding]; other site 572264001214 Fatty acid desaturase; Region: FA_desaturase; pfam00487 572264001215 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 572264001216 putative di-iron ligands [ion binding]; other site 572264001217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264001218 dimer interface [polypeptide binding]; other site 572264001219 conserved gate region; other site 572264001220 putative PBP binding loops; other site 572264001221 ABC-ATPase subunit interface; other site 572264001222 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 572264001223 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572264001224 substrate binding pocket [chemical binding]; other site 572264001225 membrane-bound complex binding site; other site 572264001226 hinge residues; other site 572264001227 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 572264001228 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 572264001229 Walker A/P-loop; other site 572264001230 ATP binding site [chemical binding]; other site 572264001231 Q-loop/lid; other site 572264001232 ABC transporter signature motif; other site 572264001233 Walker B; other site 572264001234 D-loop; other site 572264001235 H-loop/switch region; other site 572264001236 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 572264001237 HAMP domain; Region: HAMP; pfam00672 572264001238 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572264001239 dimer interface [polypeptide binding]; other site 572264001240 putative CheW interface [polypeptide binding]; other site 572264001241 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 572264001242 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 572264001243 Ca binding site [ion binding]; other site 572264001244 active site 572264001245 catalytic site [active] 572264001246 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 572264001247 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 572264001248 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 572264001249 active site turn [active] 572264001250 phosphorylation site [posttranslational modification] 572264001251 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 572264001252 putative catalytic site [active] 572264001253 putative metal binding site [ion binding]; other site 572264001254 putative phosphate binding site [ion binding]; other site 572264001255 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 572264001256 SEA domain; Region: SEA; cl02507 572264001257 Predicted membrane protein [Function unknown]; Region: COG1511 572264001258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264001259 DNA topoisomerase III; Provisional; Region: PRK07726 572264001260 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 572264001261 active site 572264001262 putative interdomain interaction site [polypeptide binding]; other site 572264001263 putative metal-binding site [ion binding]; other site 572264001264 putative nucleotide binding site [chemical binding]; other site 572264001265 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 572264001266 domain I; other site 572264001267 DNA binding groove [nucleotide binding] 572264001268 phosphate binding site [ion binding]; other site 572264001269 domain II; other site 572264001270 domain III; other site 572264001271 nucleotide binding site [chemical binding]; other site 572264001272 catalytic site [active] 572264001273 domain IV; other site 572264001274 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 572264001275 substrate binding site [chemical binding]; other site 572264001276 multimerization interface [polypeptide binding]; other site 572264001277 ATP binding site [chemical binding]; other site 572264001278 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 572264001279 thiamine phosphate binding site [chemical binding]; other site 572264001280 active site 572264001281 pyrophosphate binding site [ion binding]; other site 572264001282 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 572264001283 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 572264001284 HAMP domain; Region: HAMP; pfam00672 572264001285 dimerization interface [polypeptide binding]; other site 572264001286 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572264001287 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572264001288 dimer interface [polypeptide binding]; other site 572264001289 putative CheW interface [polypeptide binding]; other site 572264001290 Domain of unknown function DUF77; Region: DUF77; pfam01910 572264001291 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 572264001292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264001293 dimer interface [polypeptide binding]; other site 572264001294 conserved gate region; other site 572264001295 putative PBP binding loops; other site 572264001296 ABC-ATPase subunit interface; other site 572264001297 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 572264001298 NMT1/THI5 like; Region: NMT1; pfam09084 572264001299 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 572264001300 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 572264001301 Walker A/P-loop; other site 572264001302 ATP binding site [chemical binding]; other site 572264001303 Q-loop/lid; other site 572264001304 ABC transporter signature motif; other site 572264001305 Walker B; other site 572264001306 D-loop; other site 572264001307 H-loop/switch region; other site 572264001308 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 572264001309 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264001310 Walker A/P-loop; other site 572264001311 ATP binding site [chemical binding]; other site 572264001312 Q-loop/lid; other site 572264001313 ABC transporter signature motif; other site 572264001314 Walker B; other site 572264001315 D-loop; other site 572264001316 H-loop/switch region; other site 572264001317 ABC transporter; Region: ABC_tran_2; pfam12848 572264001318 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264001319 Glyco_18 domain; Region: Glyco_18; smart00636 572264001320 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 572264001321 active site 572264001322 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 572264001323 Interdomain contacts; other site 572264001324 Cytokine receptor motif; other site 572264001325 CBD_II domain; Region: CBD_II; smart00637 572264001326 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 572264001327 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 572264001328 catalytic residues [active] 572264001329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264001330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264001331 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 572264001332 H+ Antiporter protein; Region: 2A0121; TIGR00900 572264001333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264001334 putative substrate translocation pore; other site 572264001335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264001336 non-specific DNA binding site [nucleotide binding]; other site 572264001337 salt bridge; other site 572264001338 sequence-specific DNA binding site [nucleotide binding]; other site 572264001339 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 572264001340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264001341 putative substrate translocation pore; other site 572264001342 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 572264001343 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 572264001344 YesK-like protein; Region: YesK; pfam14150 572264001345 prolyl-tRNA synthetase; Provisional; Region: PRK08661 572264001346 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 572264001347 dimer interface [polypeptide binding]; other site 572264001348 motif 1; other site 572264001349 active site 572264001350 motif 2; other site 572264001351 motif 3; other site 572264001352 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 572264001353 anticodon binding site; other site 572264001354 zinc-binding site [ion binding]; other site 572264001355 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 572264001356 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 572264001357 nucleotide binding site [chemical binding]; other site 572264001358 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 572264001359 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 572264001360 putative metal binding site [ion binding]; other site 572264001361 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 572264001362 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 572264001363 putative metal binding site [ion binding]; other site 572264001364 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 572264001365 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 572264001366 putative metal binding site [ion binding]; other site 572264001367 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 572264001368 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 572264001369 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 572264001370 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 572264001371 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 572264001372 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572264001373 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 572264001374 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 572264001375 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 572264001376 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 572264001377 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 572264001378 Low molecular weight phosphatase family; Region: LMWPc; cd00115 572264001379 active site 572264001380 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 572264001381 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 572264001382 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 572264001383 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572264001384 Soluble P-type ATPase [General function prediction only]; Region: COG4087 572264001385 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 572264001386 EamA-like transporter family; Region: EamA; pfam00892 572264001387 EamA-like transporter family; Region: EamA; pfam00892 572264001388 YhhN-like protein; Region: YhhN; pfam07947 572264001389 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 572264001390 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 572264001391 Catalytic site [active] 572264001392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264001393 binding surface 572264001394 Tetratricopeptide repeat; Region: TPR_16; pfam13432 572264001395 TPR motif; other site 572264001396 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 572264001397 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 572264001398 Predicted membrane protein [Function unknown]; Region: COG2510 572264001399 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 572264001400 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 572264001401 calcium/proton exchanger (cax); Region: cax; TIGR00378 572264001402 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 572264001403 YfkD-like protein; Region: YfkD; pfam14167 572264001404 Radical SAM superfamily; Region: Radical_SAM; pfam04055 572264001405 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572264001406 FeS/SAM binding site; other site 572264001407 YfkB-like domain; Region: YfkB; pfam08756 572264001408 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 572264001409 Fumarase C-terminus; Region: Fumerase_C; pfam05683 572264001410 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 572264001411 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 572264001412 NodB motif; other site 572264001413 active site 572264001414 catalytic site [active] 572264001415 Cd binding site [ion binding]; other site 572264001416 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 572264001417 endonuclease III; Region: ENDO3c; smart00478 572264001418 minor groove reading motif; other site 572264001419 helix-hairpin-helix signature motif; other site 572264001420 substrate binding pocket [chemical binding]; other site 572264001421 active site 572264001422 TRAM domain; Region: TRAM; pfam01938 572264001423 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 572264001424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264001425 S-adenosylmethionine binding site [chemical binding]; other site 572264001426 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 572264001427 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 572264001428 dimerization interface 3.5A [polypeptide binding]; other site 572264001429 active site 572264001430 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 572264001431 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264001432 Walker A motif; other site 572264001433 ATP binding site [chemical binding]; other site 572264001434 Walker B motif; other site 572264001435 arginine finger; other site 572264001436 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 572264001437 hypothetical protein; Validated; Region: PRK06748 572264001438 S-methylmethionine transporter; Provisional; Region: PRK11387 572264001439 acetylornithine deacetylase; Validated; Region: PRK08596 572264001440 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 572264001441 metal binding site [ion binding]; metal-binding site 572264001442 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572264001443 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264001444 non-specific DNA binding site [nucleotide binding]; other site 572264001445 salt bridge; other site 572264001446 sequence-specific DNA binding site [nucleotide binding]; other site 572264001447 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 572264001448 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 572264001449 Domain of unknown function DUF; Region: DUF204; pfam02659 572264001450 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 572264001451 glutaminase A; Region: Gln_ase; TIGR03814 572264001452 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 572264001453 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 572264001454 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 572264001455 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 572264001456 active site turn [active] 572264001457 phosphorylation site [posttranslational modification] 572264001458 Beta-lactamase; Region: Beta-lactamase; pfam00144 572264001459 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572264001460 Sm and related proteins; Region: Sm_like; cl00259 572264001461 heptamer interface [polypeptide binding]; other site 572264001462 Sm1 motif; other site 572264001463 hexamer interface [polypeptide binding]; other site 572264001464 RNA binding site [nucleotide binding]; other site 572264001465 Sm2 motif; other site 572264001466 Sm and related proteins; Region: Sm_like; cl00259 572264001467 heptamer interface [polypeptide binding]; other site 572264001468 Sm1 motif; other site 572264001469 hexamer interface [polypeptide binding]; other site 572264001470 RNA binding site [nucleotide binding]; other site 572264001471 Sm2 motif; other site 572264001472 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 572264001473 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 572264001474 Ligand binding site; other site 572264001475 Putative Catalytic site; other site 572264001476 DXD motif; other site 572264001477 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 572264001478 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 572264001479 active site 572264001480 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 572264001481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572264001482 NAD(P) binding site [chemical binding]; other site 572264001483 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 572264001484 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 572264001485 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 572264001486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572264001487 NAD(P) binding site [chemical binding]; other site 572264001488 active site 572264001489 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 572264001490 active site 572264001491 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 572264001492 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 572264001493 active site 572264001494 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 572264001495 Pyruvate formate lyase 1; Region: PFL1; cd01678 572264001496 coenzyme A binding site [chemical binding]; other site 572264001497 active site 572264001498 catalytic residues [active] 572264001499 glycine loop; other site 572264001500 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 572264001501 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572264001502 FeS/SAM binding site; other site 572264001503 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 572264001504 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 572264001505 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 572264001506 YfhE-like protein; Region: YfhE; pfam14152 572264001507 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572264001508 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 572264001509 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 572264001510 active site 572264001511 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 572264001512 TIGR01777 family protein; Region: yfcH 572264001513 putative NAD(P) binding site [chemical binding]; other site 572264001514 putative active site [active] 572264001515 recombination regulator RecX; Provisional; Region: recX; PRK14135 572264001516 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 572264001517 YpzG-like protein; Region: YpzG; pfam14139 572264001518 Small acid-soluble spore protein K family; Region: SspK; pfam08176 572264001519 WVELL protein; Region: WVELL; pfam14043 572264001520 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 572264001521 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 572264001522 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 572264001523 minor groove reading motif; other site 572264001524 helix-hairpin-helix signature motif; other site 572264001525 substrate binding pocket [chemical binding]; other site 572264001526 active site 572264001527 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 572264001528 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 572264001529 DNA binding and oxoG recognition site [nucleotide binding] 572264001530 YgaB-like protein; Region: YgaB; pfam14182 572264001531 hypothetical protein; Provisional; Region: PRK13662 572264001532 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 572264001533 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 572264001534 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 572264001535 Walker A/P-loop; other site 572264001536 ATP binding site [chemical binding]; other site 572264001537 Q-loop/lid; other site 572264001538 ABC transporter signature motif; other site 572264001539 Walker B; other site 572264001540 D-loop; other site 572264001541 H-loop/switch region; other site 572264001542 Predicted membrane protein [Function unknown]; Region: COG4129 572264001543 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 572264001544 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 572264001545 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 572264001546 active site 572264001547 dimer interface [polypeptide binding]; other site 572264001548 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 572264001549 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 572264001550 active site 572264001551 FMN binding site [chemical binding]; other site 572264001552 substrate binding site [chemical binding]; other site 572264001553 3Fe-4S cluster binding site [ion binding]; other site 572264001554 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 572264001555 domain_subunit interface; other site 572264001556 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 572264001557 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 572264001558 inhibitor-cofactor binding pocket; inhibition site 572264001559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264001560 catalytic residue [active] 572264001561 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 572264001562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264001563 Walker A/P-loop; other site 572264001564 ATP binding site [chemical binding]; other site 572264001565 Q-loop/lid; other site 572264001566 ABC transporter signature motif; other site 572264001567 Walker B; other site 572264001568 D-loop; other site 572264001569 H-loop/switch region; other site 572264001570 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 572264001571 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 572264001572 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 572264001573 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 572264001574 Ion channel; Region: Ion_trans_2; pfam07885 572264001575 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 572264001576 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 572264001577 catalytic triad [active] 572264001578 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 572264001579 metal binding site 2 [ion binding]; metal-binding site 572264001580 putative DNA binding helix; other site 572264001581 metal binding site 1 [ion binding]; metal-binding site 572264001582 dimer interface [polypeptide binding]; other site 572264001583 structural Zn2+ binding site [ion binding]; other site 572264001584 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 572264001585 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 572264001586 hypothetical protein; Provisional; Region: PRK12378 572264001587 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 572264001588 nudix motif; other site 572264001589 Transglycosylase; Region: Transgly; pfam00912 572264001590 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 572264001591 Thioredoxin; Region: Thioredoxin_4; pfam13462 572264001592 epoxyqueuosine reductase; Region: TIGR00276 572264001593 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 572264001594 Putative amidase domain; Region: Amidase_6; pfam12671 572264001595 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 572264001596 PAS fold; Region: PAS_4; pfam08448 572264001597 PAS domain S-box; Region: sensory_box; TIGR00229 572264001598 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572264001599 putative active site [active] 572264001600 heme pocket [chemical binding]; other site 572264001601 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572264001602 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572264001603 metal binding site [ion binding]; metal-binding site 572264001604 active site 572264001605 I-site; other site 572264001606 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572264001607 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 572264001608 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 572264001609 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 572264001610 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 572264001611 heme-binding site [chemical binding]; other site 572264001612 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 572264001613 Leucine-rich repeats; other site 572264001614 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 572264001615 Substrate binding site [chemical binding]; other site 572264001616 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 572264001617 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 572264001618 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 572264001619 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 572264001620 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 572264001621 Leucine rich repeat; Region: LRR_8; pfam13855 572264001622 BCCT family transporter; Region: BCCT; pfam02028 572264001623 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 572264001624 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 572264001625 FOG: PKD repeat [General function prediction only]; Region: COG3291 572264001626 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 572264001627 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 572264001628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 572264001629 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 572264001630 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 572264001631 Cache domain; Region: Cache_1; pfam02743 572264001632 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264001633 dimerization interface [polypeptide binding]; other site 572264001634 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572264001635 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572264001636 dimer interface [polypeptide binding]; other site 572264001637 putative CheW interface [polypeptide binding]; other site 572264001638 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 572264001639 PAS domain; Region: PAS; smart00091 572264001640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264001641 ATP binding site [chemical binding]; other site 572264001642 Mg2+ binding site [ion binding]; other site 572264001643 G-X-G motif; other site 572264001644 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 572264001645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264001646 active site 572264001647 phosphorylation site [posttranslational modification] 572264001648 intermolecular recognition site; other site 572264001649 dimerization interface [polypeptide binding]; other site 572264001650 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 572264001651 Citrate transporter; Region: CitMHS; pfam03600 572264001652 hypothetical protein; Provisional; Region: PRK12784 572264001653 NosL; Region: NosL; cl01769 572264001654 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 572264001655 Ankyrin repeat; Region: Ank; pfam00023 572264001656 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 572264001657 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 572264001658 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 572264001659 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 572264001660 active site 572264001661 metal binding site [ion binding]; metal-binding site 572264001662 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264001663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264001664 active site 572264001665 phosphorylation site [posttranslational modification] 572264001666 intermolecular recognition site; other site 572264001667 dimerization interface [polypeptide binding]; other site 572264001668 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264001669 DNA binding site [nucleotide binding] 572264001670 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264001671 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264001672 dimer interface [polypeptide binding]; other site 572264001673 phosphorylation site [posttranslational modification] 572264001674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264001675 ATP binding site [chemical binding]; other site 572264001676 Mg2+ binding site [ion binding]; other site 572264001677 G-X-G motif; other site 572264001678 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 572264001679 putative active site [active] 572264001680 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 572264001681 Cache domain; Region: Cache_1; pfam02743 572264001682 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264001683 dimerization interface [polypeptide binding]; other site 572264001684 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572264001685 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572264001686 dimer interface [polypeptide binding]; other site 572264001687 putative CheW interface [polypeptide binding]; other site 572264001688 sensory histidine kinase DcuS; Provisional; Region: PRK11086 572264001689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264001690 ATP binding site [chemical binding]; other site 572264001691 Mg2+ binding site [ion binding]; other site 572264001692 G-X-G motif; other site 572264001693 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 572264001694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264001695 active site 572264001696 phosphorylation site [posttranslational modification] 572264001697 intermolecular recognition site; other site 572264001698 dimerization interface [polypeptide binding]; other site 572264001699 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 572264001700 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 572264001701 Malic enzyme, N-terminal domain; Region: malic; pfam00390 572264001702 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 572264001703 putative NAD(P) binding site [chemical binding]; other site 572264001704 EamA-like transporter family; Region: EamA; pfam00892 572264001705 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 572264001706 EamA-like transporter family; Region: EamA; pfam00892 572264001707 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 572264001708 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572264001709 DNA-binding site [nucleotide binding]; DNA binding site 572264001710 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572264001711 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264001712 homodimer interface [polypeptide binding]; other site 572264001713 catalytic residue [active] 572264001714 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 572264001715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264001716 Coenzyme A binding pocket [chemical binding]; other site 572264001717 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264001718 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264001719 dimerization interface [polypeptide binding]; other site 572264001720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264001721 dimer interface [polypeptide binding]; other site 572264001722 phosphorylation site [posttranslational modification] 572264001723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264001724 ATP binding site [chemical binding]; other site 572264001725 Mg2+ binding site [ion binding]; other site 572264001726 G-X-G motif; other site 572264001727 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264001728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264001729 active site 572264001730 phosphorylation site [posttranslational modification] 572264001731 intermolecular recognition site; other site 572264001732 dimerization interface [polypeptide binding]; other site 572264001733 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264001734 DNA binding site [nucleotide binding] 572264001735 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 572264001736 Arrestin_N terminal like; Region: LDB19; pfam13002 572264001737 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264001738 Coenzyme A binding pocket [chemical binding]; other site 572264001739 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 572264001740 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 572264001741 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 572264001742 catalytic loop [active] 572264001743 iron binding site [ion binding]; other site 572264001744 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 572264001745 4Fe-4S binding domain; Region: Fer4; pfam00037 572264001746 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 572264001747 [4Fe-4S] binding site [ion binding]; other site 572264001748 molybdopterin cofactor binding site; other site 572264001749 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 572264001750 molybdopterin cofactor binding site; other site 572264001751 Uncharacterized conserved protein [Function unknown]; Region: COG2427 572264001752 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 572264001753 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 572264001754 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 572264001755 putative active site [active] 572264001756 catalytic site [active] 572264001757 putative metal binding site [ion binding]; other site 572264001758 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 572264001759 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 572264001760 hexamer interface [polypeptide binding]; other site 572264001761 ligand binding site [chemical binding]; other site 572264001762 putative active site [active] 572264001763 NAD(P) binding site [chemical binding]; other site 572264001764 amino acid transporter; Region: 2A0306; TIGR00909 572264001765 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 572264001766 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264001767 dimerization interface [polypeptide binding]; other site 572264001768 putative DNA binding site [nucleotide binding]; other site 572264001769 putative Zn2+ binding site [ion binding]; other site 572264001770 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 572264001771 metal-binding site [ion binding] 572264001772 Heavy-metal-associated domain; Region: HMA; pfam00403 572264001773 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 572264001774 metal-binding site [ion binding] 572264001775 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572264001776 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264001777 motif I; other site 572264001778 motif II; other site 572264001779 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 572264001780 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 572264001781 active site 572264001782 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264001783 non-specific DNA binding site [nucleotide binding]; other site 572264001784 salt bridge; other site 572264001785 sequence-specific DNA binding site [nucleotide binding]; other site 572264001786 Tetratricopeptide repeat; Region: TPR_12; pfam13424 572264001787 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264001788 binding surface 572264001789 TPR motif; other site 572264001790 Tetratricopeptide repeat; Region: TPR_12; pfam13424 572264001791 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 572264001792 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 572264001793 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 572264001794 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 572264001795 active site 572264001796 Zn binding site [ion binding]; other site 572264001797 Uncharacterized conserved protein [Function unknown]; Region: COG0398 572264001798 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 572264001799 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 572264001800 VanW like protein; Region: VanW; pfam04294 572264001801 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 572264001802 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 572264001803 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 572264001804 Nucleoside recognition; Region: Gate; pfam07670 572264001805 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 572264001806 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 572264001807 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572264001808 putative metal binding site [ion binding]; other site 572264001809 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 572264001810 Domain of unknown function DUF21; Region: DUF21; pfam01595 572264001811 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 572264001812 Transporter associated domain; Region: CorC_HlyC; smart01091 572264001813 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 572264001814 Aspartase; Region: Aspartase; cd01357 572264001815 active sites [active] 572264001816 tetramer interface [polypeptide binding]; other site 572264001817 L-lactate permease; Region: Lactate_perm; cl00701 572264001818 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 572264001819 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264001820 dimerization interface [polypeptide binding]; other site 572264001821 putative Zn2+ binding site [ion binding]; other site 572264001822 putative DNA binding site [nucleotide binding]; other site 572264001823 HTH-like domain; Region: HTH_21; pfam13276 572264001824 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 572264001825 Integrase core domain; Region: rve; pfam00665 572264001826 Integrase core domain; Region: rve_2; pfam13333 572264001827 Transposase; Region: HTH_Tnp_1; cl17663 572264001828 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 572264001829 acid-soluble spore protein H; Provisional; Region: sspH; PRK01625 572264001830 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 572264001831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264001832 putative substrate translocation pore; other site 572264001833 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 572264001834 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 572264001835 siderophore binding site; other site 572264001836 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 572264001837 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572264001838 ABC-ATPase subunit interface; other site 572264001839 dimer interface [polypeptide binding]; other site 572264001840 putative PBP binding regions; other site 572264001841 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 572264001842 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572264001843 ABC-ATPase subunit interface; other site 572264001844 dimer interface [polypeptide binding]; other site 572264001845 putative PBP binding regions; other site 572264001846 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 572264001847 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 572264001848 Walker A/P-loop; other site 572264001849 ATP binding site [chemical binding]; other site 572264001850 Q-loop/lid; other site 572264001851 ABC transporter signature motif; other site 572264001852 Walker B; other site 572264001853 D-loop; other site 572264001854 H-loop/switch region; other site 572264001855 Methyltransferase domain; Region: Methyltransf_31; pfam13847 572264001856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264001857 S-adenosylmethionine binding site [chemical binding]; other site 572264001858 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 572264001859 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 572264001860 substrate-cofactor binding pocket; other site 572264001861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264001862 catalytic residue [active] 572264001863 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 572264001864 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 572264001865 NAD binding site [chemical binding]; other site 572264001866 homodimer interface [polypeptide binding]; other site 572264001867 active site 572264001868 putative substrate binding site [chemical binding]; other site 572264001869 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572264001870 active site 572264001871 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 572264001872 nudix motif; other site 572264001873 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 572264001874 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 572264001875 metal ion-dependent adhesion site (MIDAS); other site 572264001876 MoxR-like ATPases [General function prediction only]; Region: COG0714 572264001877 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264001878 Walker A motif; other site 572264001879 ATP binding site [chemical binding]; other site 572264001880 Walker B motif; other site 572264001881 arginine finger; other site 572264001882 cardiolipin synthetase; Reviewed; Region: PRK12452 572264001883 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 572264001884 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 572264001885 putative active site [active] 572264001886 catalytic site [active] 572264001887 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 572264001888 putative active site [active] 572264001889 catalytic site [active] 572264001890 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572264001891 PAS domain; Region: PAS_9; pfam13426 572264001892 putative active site [active] 572264001893 heme pocket [chemical binding]; other site 572264001894 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572264001895 metal binding site [ion binding]; metal-binding site 572264001896 active site 572264001897 I-site; other site 572264001898 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572264001899 Amino acid permease; Region: AA_permease_2; pfam13520 572264001900 Spore germination protein; Region: Spore_permease; cl17796 572264001901 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572264001902 DNA-binding site [nucleotide binding]; DNA binding site 572264001903 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 572264001904 UTRA domain; Region: UTRA; pfam07702 572264001905 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 572264001906 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 572264001907 active site turn [active] 572264001908 phosphorylation site [posttranslational modification] 572264001909 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 572264001910 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 572264001911 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 572264001912 Ca binding site [ion binding]; other site 572264001913 active site 572264001914 catalytic site [active] 572264001915 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 572264001916 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 572264001917 Spore germination protein; Region: Spore_permease; cl17796 572264001918 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 572264001919 GAF domain; Region: GAF_3; pfam13492 572264001920 GAF domain; Region: GAF_2; pfam13185 572264001921 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 572264001922 Histidine kinase; Region: HisKA_3; pfam07730 572264001923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264001924 ATP binding site [chemical binding]; other site 572264001925 Mg2+ binding site [ion binding]; other site 572264001926 G-X-G motif; other site 572264001927 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 572264001928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264001929 active site 572264001930 phosphorylation site [posttranslational modification] 572264001931 intermolecular recognition site; other site 572264001932 dimerization interface [polypeptide binding]; other site 572264001933 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572264001934 DNA binding residues [nucleotide binding] 572264001935 dimerization interface [polypeptide binding]; other site 572264001936 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 572264001937 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 572264001938 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 572264001939 putative active site [active] 572264001940 catalytic triad [active] 572264001941 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 572264001942 PA/protease domain interface [polypeptide binding]; other site 572264001943 putative integrin binding motif; other site 572264001944 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 572264001945 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 572264001946 dockerin binding interface; other site 572264001947 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 572264001948 CAAX protease self-immunity; Region: Abi; pfam02517 572264001949 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 572264001950 active site 572264001951 ATP binding site [chemical binding]; other site 572264001952 substrate binding site [chemical binding]; other site 572264001953 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 572264001954 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 572264001955 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 572264001956 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 572264001957 Walker A/P-loop; other site 572264001958 ATP binding site [chemical binding]; other site 572264001959 Q-loop/lid; other site 572264001960 ABC transporter signature motif; other site 572264001961 Walker B; other site 572264001962 D-loop; other site 572264001963 H-loop/switch region; other site 572264001964 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 572264001965 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572264001966 substrate binding pocket [chemical binding]; other site 572264001967 membrane-bound complex binding site; other site 572264001968 hinge residues; other site 572264001969 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 572264001970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264001971 dimer interface [polypeptide binding]; other site 572264001972 conserved gate region; other site 572264001973 putative PBP binding loops; other site 572264001974 ABC-ATPase subunit interface; other site 572264001975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264001976 dimer interface [polypeptide binding]; other site 572264001977 conserved gate region; other site 572264001978 putative PBP binding loops; other site 572264001979 ABC-ATPase subunit interface; other site 572264001980 S-methylmethionine transporter; Provisional; Region: PRK11387 572264001981 OsmC-like protein; Region: OsmC; pfam02566 572264001982 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 572264001983 nucleotide binding site/active site [active] 572264001984 HIT family signature motif; other site 572264001985 catalytic residue [active] 572264001986 RNA polymerase sigma factor; Provisional; Region: PRK12542 572264001987 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264001988 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572264001989 DNA binding residues [nucleotide binding] 572264001990 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 572264001991 Predicted transcriptional regulator [Transcription]; Region: COG2378 572264001992 HTH domain; Region: HTH_11; pfam08279 572264001993 WYL domain; Region: WYL; pfam13280 572264001994 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 572264001995 RibD C-terminal domain; Region: RibD_C; cl17279 572264001996 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264001997 dimerization interface [polypeptide binding]; other site 572264001998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264001999 dimer interface [polypeptide binding]; other site 572264002000 phosphorylation site [posttranslational modification] 572264002001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264002002 ATP binding site [chemical binding]; other site 572264002003 Mg2+ binding site [ion binding]; other site 572264002004 G-X-G motif; other site 572264002005 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264002006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264002007 active site 572264002008 phosphorylation site [posttranslational modification] 572264002009 intermolecular recognition site; other site 572264002010 dimerization interface [polypeptide binding]; other site 572264002011 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264002012 DNA binding site [nucleotide binding] 572264002013 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 572264002014 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 572264002015 Sulfate transporter family; Region: Sulfate_transp; pfam00916 572264002016 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 572264002017 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 572264002018 Ligand Binding Site [chemical binding]; other site 572264002019 Protein of unknown function (DUF4027); Region: DUF4027; pfam13219 572264002020 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 572264002021 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 572264002022 peptide binding site [polypeptide binding]; other site 572264002023 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 572264002024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264002025 dimer interface [polypeptide binding]; other site 572264002026 conserved gate region; other site 572264002027 putative PBP binding loops; other site 572264002028 ABC-ATPase subunit interface; other site 572264002029 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 572264002030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264002031 putative PBP binding loops; other site 572264002032 ABC-ATPase subunit interface; other site 572264002033 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 572264002034 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572264002035 Walker A/P-loop; other site 572264002036 ATP binding site [chemical binding]; other site 572264002037 Q-loop/lid; other site 572264002038 ABC transporter signature motif; other site 572264002039 Walker B; other site 572264002040 D-loop; other site 572264002041 H-loop/switch region; other site 572264002042 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 572264002043 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 572264002044 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572264002045 Walker A/P-loop; other site 572264002046 ATP binding site [chemical binding]; other site 572264002047 Q-loop/lid; other site 572264002048 ABC transporter signature motif; other site 572264002049 Walker B; other site 572264002050 D-loop; other site 572264002051 H-loop/switch region; other site 572264002052 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 572264002053 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 572264002054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264002055 putative substrate translocation pore; other site 572264002056 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 572264002057 MarR family; Region: MarR; pfam01047 572264002058 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 572264002059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264002060 putative substrate translocation pore; other site 572264002061 Transcriptional regulators [Transcription]; Region: PurR; COG1609 572264002062 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 572264002063 DNA binding site [nucleotide binding] 572264002064 domain linker motif; other site 572264002065 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 572264002066 dimerization interface [polypeptide binding]; other site 572264002067 ligand binding site [chemical binding]; other site 572264002068 sodium binding site [ion binding]; other site 572264002069 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 572264002070 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 572264002071 substrate binding site [chemical binding]; other site 572264002072 dimer interface [polypeptide binding]; other site 572264002073 ATP binding site [chemical binding]; other site 572264002074 D-ribose pyranase; Provisional; Region: PRK11797 572264002075 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 572264002076 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 572264002077 Walker A/P-loop; other site 572264002078 ATP binding site [chemical binding]; other site 572264002079 Q-loop/lid; other site 572264002080 ABC transporter signature motif; other site 572264002081 Walker B; other site 572264002082 D-loop; other site 572264002083 H-loop/switch region; other site 572264002084 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 572264002085 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 572264002086 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 572264002087 TM-ABC transporter signature motif; other site 572264002088 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 572264002089 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 572264002090 ligand binding site [chemical binding]; other site 572264002091 dimerization interface [polypeptide binding]; other site 572264002092 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 572264002093 active site 572264002094 intersubunit interactions; other site 572264002095 catalytic residue [active] 572264002096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 572264002097 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 572264002098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264002099 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264002100 putative substrate translocation pore; other site 572264002101 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 572264002102 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 572264002103 putative NAD(P) binding site [chemical binding]; other site 572264002104 catalytic Zn binding site [ion binding]; other site 572264002105 Ion channel; Region: Ion_trans_2; pfam07885 572264002106 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 572264002107 Zn binding site [ion binding]; other site 572264002108 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 572264002109 putative catalytic site [active] 572264002110 metal binding site A [ion binding]; metal-binding site 572264002111 phosphate binding site [ion binding]; other site 572264002112 metal binding site C [ion binding]; metal-binding site 572264002113 metal binding site B [ion binding]; metal-binding site 572264002114 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 572264002115 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 572264002116 dimer interface [polypeptide binding]; other site 572264002117 active site 572264002118 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 572264002119 substrate binding site [chemical binding]; other site 572264002120 catalytic residue [active] 572264002121 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 572264002122 FAD binding domain; Region: FAD_binding_4; pfam01565 572264002123 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 572264002124 VanZ like family; Region: VanZ; pfam04892 572264002125 RDD family; Region: RDD; pfam06271 572264002126 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 572264002127 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572264002128 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572264002129 dimer interface [polypeptide binding]; other site 572264002130 putative CheW interface [polypeptide binding]; other site 572264002131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 572264002132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 572264002133 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572264002134 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264002135 non-specific DNA binding site [nucleotide binding]; other site 572264002136 salt bridge; other site 572264002137 sequence-specific DNA binding site [nucleotide binding]; other site 572264002138 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 572264002139 active site 572264002140 catalytic site [active] 572264002141 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 572264002142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264002143 putative substrate translocation pore; other site 572264002144 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 572264002145 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 572264002146 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 572264002147 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 572264002148 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 572264002149 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 572264002150 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572264002151 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264002152 non-specific DNA binding site [nucleotide binding]; other site 572264002153 salt bridge; other site 572264002154 sequence-specific DNA binding site [nucleotide binding]; other site 572264002155 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264002156 Coenzyme A binding pocket [chemical binding]; other site 572264002157 Protein of unknown function (DUF4022); Region: DUF4022; pfam13214 572264002158 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 572264002159 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 572264002160 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 572264002161 TrkA-N domain; Region: TrkA_N; pfam02254 572264002162 TrkA-C domain; Region: TrkA_C; pfam02080 572264002163 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 572264002164 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 572264002165 Subunit I/III interface [polypeptide binding]; other site 572264002166 Subunit III/IV interface [polypeptide binding]; other site 572264002167 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 572264002168 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 572264002169 D-pathway; other site 572264002170 Putative ubiquinol binding site [chemical binding]; other site 572264002171 Low-spin heme (heme b) binding site [chemical binding]; other site 572264002172 Putative water exit pathway; other site 572264002173 Binuclear center (heme o3/CuB) [ion binding]; other site 572264002174 K-pathway; other site 572264002175 Putative proton exit pathway; other site 572264002176 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 572264002177 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 572264002178 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 572264002179 putative active site [active] 572264002180 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 572264002181 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 572264002182 metal binding site [ion binding]; metal-binding site 572264002183 dimer interface [polypeptide binding]; other site 572264002184 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 572264002185 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 572264002186 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 572264002187 Na binding site [ion binding]; other site 572264002188 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 572264002189 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 572264002190 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 572264002191 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 572264002192 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 572264002193 Nucleoside recognition; Region: Gate; pfam07670 572264002194 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 572264002195 Nucleoside recognition; Region: Gate; pfam07670 572264002196 FeoA domain; Region: FeoA; pfam04023 572264002197 phosphate binding protein; Region: ptsS_2; TIGR02136 572264002198 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 572264002199 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 572264002200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264002201 dimer interface [polypeptide binding]; other site 572264002202 conserved gate region; other site 572264002203 putative PBP binding loops; other site 572264002204 ABC-ATPase subunit interface; other site 572264002205 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 572264002206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264002207 dimer interface [polypeptide binding]; other site 572264002208 conserved gate region; other site 572264002209 putative PBP binding loops; other site 572264002210 ABC-ATPase subunit interface; other site 572264002211 AAA domain; Region: AAA_33; pfam13671 572264002212 AAA domain; Region: AAA_17; pfam13207 572264002213 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 572264002214 FOG: CBS domain [General function prediction only]; Region: COG0517 572264002215 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 572264002216 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 572264002217 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 572264002218 Bacterial SH3 domain; Region: SH3_3; pfam08239 572264002219 Bacterial SH3 domain; Region: SH3_3; pfam08239 572264002220 Bacterial SH3 domain; Region: SH3_3; pfam08239 572264002221 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 572264002222 Peptidase family M23; Region: Peptidase_M23; pfam01551 572264002223 Putative transcription activator [Transcription]; Region: TenA; COG0819 572264002224 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 572264002225 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 572264002226 Walker A/P-loop; other site 572264002227 ATP binding site [chemical binding]; other site 572264002228 Q-loop/lid; other site 572264002229 ABC transporter signature motif; other site 572264002230 Walker B; other site 572264002231 D-loop; other site 572264002232 H-loop/switch region; other site 572264002233 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 572264002234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264002235 dimer interface [polypeptide binding]; other site 572264002236 conserved gate region; other site 572264002237 putative PBP binding loops; other site 572264002238 ABC-ATPase subunit interface; other site 572264002239 NMT1/THI5 like; Region: NMT1; pfam09084 572264002240 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 572264002241 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 572264002242 thiamine phosphate binding site [chemical binding]; other site 572264002243 active site 572264002244 pyrophosphate binding site [ion binding]; other site 572264002245 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 572264002246 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 572264002247 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 572264002248 thiS-thiF/thiG interaction site; other site 572264002249 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 572264002250 ThiS interaction site; other site 572264002251 putative active site [active] 572264002252 tetramer interface [polypeptide binding]; other site 572264002253 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 572264002254 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 572264002255 ATP binding site [chemical binding]; other site 572264002256 substrate interface [chemical binding]; other site 572264002257 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 572264002258 dimer interface [polypeptide binding]; other site 572264002259 substrate binding site [chemical binding]; other site 572264002260 ATP binding site [chemical binding]; other site 572264002261 ydaO/yuaA leader 572264002262 ydaO/yuaA leader 572264002263 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 572264002264 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 572264002265 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572264002266 Soluble P-type ATPase [General function prediction only]; Region: COG4087 572264002267 potassium-transporting ATPase subunit C; Provisional; Region: PRK13997 572264002268 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 572264002269 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 572264002270 Ligand Binding Site [chemical binding]; other site 572264002271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264002272 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264002273 putative substrate translocation pore; other site 572264002274 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 572264002275 MarR family; Region: MarR; pfam01047 572264002276 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 572264002277 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 572264002278 active site 572264002279 nucleophile elbow; other site 572264002280 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 572264002281 FtsX-like permease family; Region: FtsX; pfam02687 572264002282 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 572264002283 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 572264002284 FtsX-like permease family; Region: FtsX; pfam02687 572264002285 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572264002286 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572264002287 Walker A/P-loop; other site 572264002288 ATP binding site [chemical binding]; other site 572264002289 Q-loop/lid; other site 572264002290 ABC transporter signature motif; other site 572264002291 Walker B; other site 572264002292 D-loop; other site 572264002293 H-loop/switch region; other site 572264002294 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 572264002295 short chain dehydrogenase; Provisional; Region: PRK06701 572264002296 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 572264002297 NAD binding site [chemical binding]; other site 572264002298 metal binding site [ion binding]; metal-binding site 572264002299 active site 572264002300 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 572264002301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 572264002302 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 572264002303 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 572264002304 putative substrate binding site [chemical binding]; other site 572264002305 putative ATP binding site [chemical binding]; other site 572264002306 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 572264002307 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 572264002308 substrate binding [chemical binding]; other site 572264002309 active site 572264002310 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 572264002311 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 572264002312 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 572264002313 active site turn [active] 572264002314 phosphorylation site [posttranslational modification] 572264002315 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 572264002316 Transcriptional regulators [Transcription]; Region: PurR; COG1609 572264002317 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 572264002318 DNA binding site [nucleotide binding] 572264002319 domain linker motif; other site 572264002320 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 572264002321 dimerization interface [polypeptide binding]; other site 572264002322 ligand binding site [chemical binding]; other site 572264002323 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 572264002324 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 572264002325 catalytic residues [active] 572264002326 putative disulfide oxidoreductase; Provisional; Region: PRK03113 572264002327 YhdB-like protein; Region: YhdB; pfam14148 572264002328 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 572264002329 Spore germination protein; Region: Spore_permease; cl17796 572264002330 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 572264002331 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 572264002332 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 572264002333 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 572264002334 putative FMN binding site [chemical binding]; other site 572264002335 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 572264002336 SpoVR like protein; Region: SpoVR; pfam04293 572264002337 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 572264002338 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572264002339 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572264002340 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 572264002341 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 572264002342 active site residue [active] 572264002343 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 572264002344 putative homodimer interface [polypeptide binding]; other site 572264002345 putative homotetramer interface [polypeptide binding]; other site 572264002346 putative metal binding site [ion binding]; other site 572264002347 putative homodimer-homodimer interface [polypeptide binding]; other site 572264002348 putative allosteric switch controlling residues; other site 572264002349 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 572264002350 CPxP motif; other site 572264002351 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 572264002352 active site residue [active] 572264002353 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 572264002354 active site residue [active] 572264002355 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572264002356 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 572264002357 CPxP motif; other site 572264002358 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 572264002359 active site residue [active] 572264002360 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 572264002361 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 572264002362 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 572264002363 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 572264002364 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 572264002365 NADP binding site [chemical binding]; other site 572264002366 dimer interface [polypeptide binding]; other site 572264002367 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 572264002368 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 572264002369 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 572264002370 PhoU domain; Region: PhoU; pfam01895 572264002371 PhoU domain; Region: PhoU; pfam01895 572264002372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264002373 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264002374 putative substrate translocation pore; other site 572264002375 Uncharacterized conserved protein [Function unknown]; Region: COG3589 572264002376 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 572264002377 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 572264002378 HTH domain; Region: HTH_11; pfam08279 572264002379 Mga helix-turn-helix domain; Region: Mga; pfam05043 572264002380 PRD domain; Region: PRD; pfam00874 572264002381 PRD domain; Region: PRD; pfam00874 572264002382 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 572264002383 active site 572264002384 P-loop; other site 572264002385 phosphorylation site [posttranslational modification] 572264002386 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 572264002387 active site 572264002388 phosphorylation site [posttranslational modification] 572264002389 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 572264002390 active site 572264002391 methionine cluster; other site 572264002392 phosphorylation site [posttranslational modification] 572264002393 metal binding site [ion binding]; metal-binding site 572264002394 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 572264002395 active site 572264002396 P-loop; other site 572264002397 phosphorylation site [posttranslational modification] 572264002398 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 572264002399 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 572264002400 Uncharacterized conserved protein [Function unknown]; Region: COG3589 572264002401 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 572264002402 Bacterial SH3 domain; Region: SH3_3; pfam08239 572264002403 Bacterial SH3 domain; Region: SH3_3; pfam08239 572264002404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 572264002405 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 572264002406 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 572264002407 FtsX-like permease family; Region: FtsX; pfam02687 572264002408 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572264002409 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572264002410 Walker A/P-loop; other site 572264002411 ATP binding site [chemical binding]; other site 572264002412 Q-loop/lid; other site 572264002413 ABC transporter signature motif; other site 572264002414 Walker B; other site 572264002415 D-loop; other site 572264002416 H-loop/switch region; other site 572264002417 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 572264002418 HlyD family secretion protein; Region: HlyD_3; pfam13437 572264002419 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 572264002420 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 572264002421 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 572264002422 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 572264002423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264002424 dimer interface [polypeptide binding]; other site 572264002425 conserved gate region; other site 572264002426 ABC-ATPase subunit interface; other site 572264002427 FtsX-like permease family; Region: FtsX; pfam02687 572264002428 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 572264002429 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 572264002430 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 572264002431 dimanganese center [ion binding]; other site 572264002432 CotJB protein; Region: CotJB; pfam12652 572264002433 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 572264002434 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572264002435 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 572264002436 active site 572264002437 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 572264002438 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 572264002439 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 572264002440 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 572264002441 putative DNA binding site [nucleotide binding]; other site 572264002442 putative homodimer interface [polypeptide binding]; other site 572264002443 yybP-ykoY leader 572264002444 Uncharacterized conserved protein [Function unknown]; Region: COG3339 572264002445 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 572264002446 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 572264002447 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 572264002448 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 572264002449 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 572264002450 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 572264002451 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 572264002452 active site 572264002453 metal binding site [ion binding]; metal-binding site 572264002454 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 572264002455 Interdomain contacts; other site 572264002456 Cytokine receptor motif; other site 572264002457 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 572264002458 amino acid transporter; Region: 2A0306; TIGR00909 572264002459 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 572264002460 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 572264002461 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 572264002462 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 572264002463 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 572264002464 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 572264002465 putative active site [active] 572264002466 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 572264002467 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 572264002468 putative active site [active] 572264002469 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 572264002470 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 572264002471 active site turn [active] 572264002472 phosphorylation site [posttranslational modification] 572264002473 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 572264002474 Probable transposase; Region: OrfB_IS605; pfam01385 572264002475 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 572264002476 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 572264002477 Uncharacterized conserved protein [Function unknown]; Region: COG3589 572264002478 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 572264002479 DoxX; Region: DoxX; pfam07681 572264002480 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 572264002481 hypothetical protein; Provisional; Region: PRK06770 572264002482 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 572264002483 EamA-like transporter family; Region: EamA; pfam00892 572264002484 EamA-like transporter family; Region: EamA; pfam00892 572264002485 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 572264002486 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 572264002487 AsnC family; Region: AsnC_trans_reg; pfam01037 572264002488 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264002489 Coenzyme A binding pocket [chemical binding]; other site 572264002490 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 572264002491 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 572264002492 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264002493 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264002494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264002495 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264002496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264002497 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 572264002498 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 572264002499 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 572264002500 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264002501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264002502 putative substrate translocation pore; other site 572264002503 intracellular protease, PfpI family; Region: PfpI; TIGR01382 572264002504 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 572264002505 proposed catalytic triad [active] 572264002506 conserved cys residue [active] 572264002507 hydroperoxidase II; Provisional; Region: katE; PRK11249 572264002508 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 572264002509 tetramer interface [polypeptide binding]; other site 572264002510 heme binding pocket [chemical binding]; other site 572264002511 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 572264002512 domain interactions; other site 572264002513 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 572264002514 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 572264002515 Spore germination protein; Region: Spore_permease; cl17796 572264002516 Lysine riboswitch 572264002517 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 572264002518 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 572264002519 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 572264002520 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 572264002521 tetrameric interface [polypeptide binding]; other site 572264002522 activator binding site; other site 572264002523 NADP binding site [chemical binding]; other site 572264002524 substrate binding site [chemical binding]; other site 572264002525 catalytic residues [active] 572264002526 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 572264002527 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 572264002528 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264002529 Walker A/P-loop; other site 572264002530 ATP binding site [chemical binding]; other site 572264002531 Q-loop/lid; other site 572264002532 ABC transporter signature motif; other site 572264002533 Walker B; other site 572264002534 D-loop; other site 572264002535 H-loop/switch region; other site 572264002536 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 572264002537 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 572264002538 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 572264002539 Walker A/P-loop; other site 572264002540 ATP binding site [chemical binding]; other site 572264002541 Q-loop/lid; other site 572264002542 ABC transporter signature motif; other site 572264002543 Walker B; other site 572264002544 D-loop; other site 572264002545 H-loop/switch region; other site 572264002546 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 572264002547 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572264002548 substrate binding pocket [chemical binding]; other site 572264002549 membrane-bound complex binding site; other site 572264002550 hinge residues; other site 572264002551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264002552 dimer interface [polypeptide binding]; other site 572264002553 conserved gate region; other site 572264002554 putative PBP binding loops; other site 572264002555 ABC-ATPase subunit interface; other site 572264002556 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 572264002557 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 572264002558 Walker A/P-loop; other site 572264002559 ATP binding site [chemical binding]; other site 572264002560 Q-loop/lid; other site 572264002561 ABC transporter signature motif; other site 572264002562 Walker B; other site 572264002563 D-loop; other site 572264002564 H-loop/switch region; other site 572264002565 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 572264002566 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 572264002567 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 572264002568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 572264002569 hypothetical protein; Provisional; Region: PRK13676 572264002570 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 572264002571 acetolactate synthase; Reviewed; Region: PRK08617 572264002572 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 572264002573 PYR/PP interface [polypeptide binding]; other site 572264002574 dimer interface [polypeptide binding]; other site 572264002575 TPP binding site [chemical binding]; other site 572264002576 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 572264002577 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 572264002578 TPP-binding site [chemical binding]; other site 572264002579 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 572264002580 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 572264002581 active site 572264002582 DNA binding site [nucleotide binding] 572264002583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 572264002584 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 572264002585 active site 572264002586 motif I; other site 572264002587 motif II; other site 572264002588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264002589 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 572264002590 amidase catalytic site [active] 572264002591 Zn binding residues [ion binding]; other site 572264002592 substrate binding site [chemical binding]; other site 572264002593 S-layer homology domain; Region: SLH; pfam00395 572264002594 S-layer homology domain; Region: SLH; pfam00395 572264002595 S-layer homology domain; Region: SLH; pfam00395 572264002596 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 572264002597 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 572264002598 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572264002599 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 572264002600 acyl-activating enzyme (AAE) consensus motif; other site 572264002601 acyl-activating enzyme (AAE) consensus motif; other site 572264002602 putative AMP binding site [chemical binding]; other site 572264002603 putative active site [active] 572264002604 putative CoA binding site [chemical binding]; other site 572264002605 high affinity sulphate transporter 1; Region: sulP; TIGR00815 572264002606 Sulfate transporter family; Region: Sulfate_transp; pfam00916 572264002607 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 572264002608 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 572264002609 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 572264002610 ATP binding site [chemical binding]; other site 572264002611 putative Mg++ binding site [ion binding]; other site 572264002612 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 572264002613 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572264002614 nucleotide binding region [chemical binding]; other site 572264002615 ATP-binding site [chemical binding]; other site 572264002616 stage V sporulation protein B; Region: spore_V_B; TIGR02900 572264002617 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 572264002618 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 572264002619 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 572264002620 S-layer homology domain; Region: SLH; pfam00395 572264002621 S-layer homology domain; Region: SLH; pfam00395 572264002622 S-layer homology domain; Region: SLH; pfam00395 572264002623 S-layer homology domain; Region: SLH; pfam00395 572264002624 S-layer homology domain; Region: SLH; pfam00395 572264002625 S-layer homology domain; Region: SLH; pfam00395 572264002626 DHHW protein; Region: DHHW; pfam14286 572264002627 DHHW protein; Region: DHHW; pfam14286 572264002628 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 572264002629 enoyl-CoA hydratase; Provisional; Region: PRK07659 572264002630 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572264002631 substrate binding site [chemical binding]; other site 572264002632 oxyanion hole (OAH) forming residues; other site 572264002633 trimer interface [polypeptide binding]; other site 572264002634 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 572264002635 metal binding site [ion binding]; metal-binding site 572264002636 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 572264002637 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 572264002638 putative oligomer interface [polypeptide binding]; other site 572264002639 putative active site [active] 572264002640 metal binding site [ion binding]; metal-binding site 572264002641 S-layer homology domain; Region: SLH; pfam00395 572264002642 S-layer homology domain; Region: SLH; pfam00395 572264002643 S-layer homology domain; Region: SLH; pfam00395 572264002644 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 572264002645 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 572264002646 active site 572264002647 metal binding site [ion binding]; metal-binding site 572264002648 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 572264002649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264002650 S-adenosylmethionine binding site [chemical binding]; other site 572264002651 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 572264002652 proline racemase; Provisional; Region: PRK13969 572264002653 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 572264002654 ornithine cyclodeaminase; Validated; Region: PRK08618 572264002655 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 572264002656 NAD(P) binding site [chemical binding]; other site 572264002657 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 572264002658 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 572264002659 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 572264002660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264002661 dimer interface [polypeptide binding]; other site 572264002662 conserved gate region; other site 572264002663 putative PBP binding loops; other site 572264002664 ABC-ATPase subunit interface; other site 572264002665 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 572264002666 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 572264002667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264002668 dimer interface [polypeptide binding]; other site 572264002669 conserved gate region; other site 572264002670 putative PBP binding loops; other site 572264002671 ABC-ATPase subunit interface; other site 572264002672 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 572264002673 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572264002674 Walker A/P-loop; other site 572264002675 ATP binding site [chemical binding]; other site 572264002676 Q-loop/lid; other site 572264002677 ABC transporter signature motif; other site 572264002678 Walker B; other site 572264002679 D-loop; other site 572264002680 H-loop/switch region; other site 572264002681 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 572264002682 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 572264002683 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572264002684 Walker A/P-loop; other site 572264002685 ATP binding site [chemical binding]; other site 572264002686 Q-loop/lid; other site 572264002687 ABC transporter signature motif; other site 572264002688 Walker B; other site 572264002689 D-loop; other site 572264002690 H-loop/switch region; other site 572264002691 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 572264002692 Predicted transcriptional regulator [Transcription]; Region: COG2378 572264002693 WYL domain; Region: WYL; pfam13280 572264002694 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 572264002695 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 572264002696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264002697 putative substrate translocation pore; other site 572264002698 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 572264002699 PAS domain; Region: PAS; smart00091 572264002700 putative active site [active] 572264002701 heme pocket [chemical binding]; other site 572264002702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264002703 ATP binding site [chemical binding]; other site 572264002704 Mg2+ binding site [ion binding]; other site 572264002705 G-X-G motif; other site 572264002706 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 572264002707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264002708 active site 572264002709 phosphorylation site [posttranslational modification] 572264002710 intermolecular recognition site; other site 572264002711 dimerization interface [polypeptide binding]; other site 572264002712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 572264002713 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 572264002714 active site 572264002715 DNA binding site [nucleotide binding] 572264002716 Int/Topo IB signature motif; other site 572264002717 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 572264002718 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 572264002719 cofactor binding site; other site 572264002720 DNA binding site [nucleotide binding] 572264002721 substrate interaction site [chemical binding]; other site 572264002722 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 572264002723 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 572264002724 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 572264002725 cofactor binding site; other site 572264002726 DNA binding site [nucleotide binding] 572264002727 substrate interaction site [chemical binding]; other site 572264002728 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 572264002729 HTH-like domain; Region: HTH_21; pfam13276 572264002730 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 572264002731 Integrase core domain; Region: rve; pfam00665 572264002732 Integrase core domain; Region: rve_2; pfam13333 572264002733 Transposase; Region: HTH_Tnp_1; cl17663 572264002734 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 572264002735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 572264002736 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 572264002737 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 572264002738 LlaJI restriction endonuclease; Region: RE_LlaJI; pfam09563 572264002739 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 572264002740 replicative DNA helicase; Provisional; Region: PRK06749 572264002741 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 572264002742 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 572264002743 Walker A motif; other site 572264002744 ATP binding site [chemical binding]; other site 572264002745 Walker B motif; other site 572264002746 DNA binding loops [nucleotide binding] 572264002747 Predicted transcriptional regulators [Transcription]; Region: COG1378 572264002748 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 572264002749 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 572264002750 C-terminal domain interface [polypeptide binding]; other site 572264002751 sugar binding site [chemical binding]; other site 572264002752 hypothetical protein; Provisional; Region: PRK10621 572264002753 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 572264002754 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264002755 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264002756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264002757 putative substrate translocation pore; other site 572264002758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264002759 Predicted permease; Region: DUF318; cl17795 572264002760 Predicted permease; Region: DUF318; cl17795 572264002761 Predicted transcriptional regulators [Transcription]; Region: COG1695 572264002762 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 572264002763 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 572264002764 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 572264002765 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 572264002766 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 572264002767 CGNR zinc finger; Region: zf-CGNR; pfam11706 572264002768 HPP family; Region: HPP; pfam04982 572264002769 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 572264002770 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 572264002771 putative NAD(P) binding site [chemical binding]; other site 572264002772 active site 572264002773 putative substrate binding site [chemical binding]; other site 572264002774 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572264002775 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264002776 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264002777 YmzC-like protein; Region: YmzC; pfam14157 572264002778 Transcriptional regulators [Transcription]; Region: MarR; COG1846 572264002779 MarR family; Region: MarR_2; pfam12802 572264002780 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 572264002781 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 572264002782 ATP synthase I chain; Region: ATP_synt_I; pfam03899 572264002783 VanZ like family; Region: VanZ; pfam04892 572264002784 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 572264002785 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 572264002786 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 572264002787 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 572264002788 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264002789 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 572264002790 dihydroxyacetone kinase; Provisional; Region: PRK14479 572264002791 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 572264002792 DAK2 domain; Region: Dak2; pfam02734 572264002793 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 572264002794 Predicted transcriptional regulator [Transcription]; Region: COG1959 572264002795 Transcriptional regulator; Region: Rrf2; pfam02082 572264002796 DAK2 domain; Region: Dak2; pfam02734 572264002797 Bacterial SH3 domain; Region: SH3_3; cl17532 572264002798 Tetratricopeptide repeat; Region: TPR_12; pfam13424 572264002799 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 572264002800 TPR motif; other site 572264002801 binding surface 572264002802 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 572264002803 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572264002804 Zn2+ binding site [ion binding]; other site 572264002805 Mg2+ binding site [ion binding]; other site 572264002806 S-layer homology domain; Region: SLH; pfam00395 572264002807 S-layer homology domain; Region: SLH; pfam00395 572264002808 S-layer homology domain; Region: SLH; pfam00395 572264002809 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 572264002810 Predicted transcriptional regulators [Transcription]; Region: COG1695 572264002811 Transcriptional regulator PadR-like family; Region: PadR; cl17335 572264002812 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 572264002813 Heat induced stress protein YflT; Region: YflT; pfam11181 572264002814 Predicted membrane protein [Function unknown]; Region: COG2261 572264002815 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 572264002816 anti sigma factor interaction site; other site 572264002817 regulatory phosphorylation site [posttranslational modification]; other site 572264002818 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 572264002819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264002820 ATP binding site [chemical binding]; other site 572264002821 Mg2+ binding site [ion binding]; other site 572264002822 G-X-G motif; other site 572264002823 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 572264002824 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264002825 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 572264002826 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572264002827 DNA binding residues [nucleotide binding] 572264002828 Ferritin-like domain; Region: Ferritin; pfam00210 572264002829 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 572264002830 dinuclear metal binding motif [ion binding]; other site 572264002831 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 572264002832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264002833 active site 572264002834 phosphorylation site [posttranslational modification] 572264002835 intermolecular recognition site; other site 572264002836 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 572264002837 dimerization interface [polypeptide binding]; other site 572264002838 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 572264002839 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 572264002840 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 572264002841 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 572264002842 CHASE3 domain; Region: CHASE3; pfam05227 572264002843 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 572264002844 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 572264002845 GAF domain; Region: GAF; pfam01590 572264002846 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264002847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264002848 dimer interface [polypeptide binding]; other site 572264002849 phosphorylation site [posttranslational modification] 572264002850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264002851 ATP binding site [chemical binding]; other site 572264002852 Mg2+ binding site [ion binding]; other site 572264002853 G-X-G motif; other site 572264002854 Response regulator receiver domain; Region: Response_reg; pfam00072 572264002855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264002856 active site 572264002857 phosphorylation site [posttranslational modification] 572264002858 intermolecular recognition site; other site 572264002859 dimerization interface [polypeptide binding]; other site 572264002860 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 572264002861 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 572264002862 hypothetical protein; Provisional; Region: PRK12856 572264002863 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 572264002864 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 572264002865 NADP binding site [chemical binding]; other site 572264002866 dimer interface [polypeptide binding]; other site 572264002867 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 572264002868 YhzD-like protein; Region: YhzD; pfam14120 572264002869 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 572264002870 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 572264002871 active site 572264002872 metal binding site [ion binding]; metal-binding site 572264002873 DNA binding site [nucleotide binding] 572264002874 AAA domain; Region: AAA_27; pfam13514 572264002875 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264002876 Q-loop/lid; other site 572264002877 ABC transporter signature motif; other site 572264002878 Walker B; other site 572264002879 D-loop; other site 572264002880 H-loop/switch region; other site 572264002881 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 572264002882 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 572264002883 generic binding surface II; other site 572264002884 generic binding surface I; other site 572264002885 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572264002886 Zn2+ binding site [ion binding]; other site 572264002887 Mg2+ binding site [ion binding]; other site 572264002888 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 572264002889 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 572264002890 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 572264002891 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572264002892 Zn binding site [ion binding]; other site 572264002893 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 572264002894 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572264002895 Zn binding site [ion binding]; other site 572264002896 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 572264002897 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572264002898 Zn binding site [ion binding]; other site 572264002899 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 572264002900 Zn binding site [ion binding]; other site 572264002901 Tetratricopeptide repeat; Region: TPR_12; pfam13424 572264002902 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264002903 TPR motif; other site 572264002904 binding surface 572264002905 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 572264002906 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 572264002907 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 572264002908 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 572264002909 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 572264002910 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264002911 non-specific DNA binding site [nucleotide binding]; other site 572264002912 salt bridge; other site 572264002913 sequence-specific DNA binding site [nucleotide binding]; other site 572264002914 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 572264002915 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 572264002916 amphipathic channel; other site 572264002917 Asn-Pro-Ala signature motifs; other site 572264002918 glycerol kinase; Provisional; Region: glpK; PRK00047 572264002919 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 572264002920 N- and C-terminal domain interface [polypeptide binding]; other site 572264002921 active site 572264002922 MgATP binding site [chemical binding]; other site 572264002923 catalytic site [active] 572264002924 metal binding site [ion binding]; metal-binding site 572264002925 glycerol binding site [chemical binding]; other site 572264002926 homotetramer interface [polypeptide binding]; other site 572264002927 homodimer interface [polypeptide binding]; other site 572264002928 FBP binding site [chemical binding]; other site 572264002929 protein IIAGlc interface [polypeptide binding]; other site 572264002930 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 572264002931 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 572264002932 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 572264002933 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264002934 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572264002935 DNA binding residues [nucleotide binding] 572264002936 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 572264002937 Predicted transcriptional regulators [Transcription]; Region: COG1695 572264002938 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 572264002939 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 572264002940 MarR family; Region: MarR; pfam01047 572264002941 DoxX-like family; Region: DoxX_2; pfam13564 572264002942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264002943 putative substrate translocation pore; other site 572264002944 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 572264002945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264002946 putative substrate translocation pore; other site 572264002947 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 572264002948 Part of AAA domain; Region: AAA_19; pfam13245 572264002949 Family description; Region: UvrD_C_2; pfam13538 572264002950 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 572264002951 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 572264002952 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 572264002953 transcriptional regulator Hpr; Provisional; Region: PRK13777 572264002954 MarR family; Region: MarR; pfam01047 572264002955 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 572264002956 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 572264002957 HIT family signature motif; other site 572264002958 catalytic residue [active] 572264002959 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 572264002960 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 572264002961 Walker A/P-loop; other site 572264002962 ATP binding site [chemical binding]; other site 572264002963 Q-loop/lid; other site 572264002964 ABC transporter signature motif; other site 572264002965 Walker B; other site 572264002966 D-loop; other site 572264002967 H-loop/switch region; other site 572264002968 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 572264002969 EcsC protein family; Region: EcsC; pfam12787 572264002970 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 572264002971 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 572264002972 nucleophilic elbow; other site 572264002973 catalytic triad; other site 572264002974 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264002975 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264002976 Uncharacterized conserved protein [Function unknown]; Region: COG3402 572264002977 Predicted membrane protein [Function unknown]; Region: COG3428 572264002978 Bacterial PH domain; Region: DUF304; pfam03703 572264002979 Bacterial PH domain; Region: DUF304; cl01348 572264002980 Bacterial PH domain; Region: DUF304; pfam03703 572264002981 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 572264002982 S-layer homology domain; Region: SLH; pfam00395 572264002983 S-layer homology domain; Region: SLH; pfam00395 572264002984 S-layer homology domain; Region: SLH; pfam00395 572264002985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 572264002986 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 572264002987 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 572264002988 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 572264002989 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 572264002990 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 572264002991 DNA binding residues [nucleotide binding] 572264002992 drug binding residues [chemical binding]; other site 572264002993 dimer interface [polypeptide binding]; other site 572264002994 Uncharacterized conserved protein [Function unknown]; Region: COG3402 572264002995 Predicted membrane protein [Function unknown]; Region: COG3428 572264002996 Bacterial PH domain; Region: DUF304; pfam03703 572264002997 Bacterial PH domain; Region: DUF304; pfam03703 572264002998 Bacterial PH domain; Region: DUF304; pfam03703 572264002999 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 572264003000 Transglycosylase; Region: Transgly; pfam00912 572264003001 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 572264003002 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572264003003 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 572264003004 substrate binding site [chemical binding]; other site 572264003005 active site 572264003006 ferrochelatase; Provisional; Region: PRK12435 572264003007 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 572264003008 C-terminal domain interface [polypeptide binding]; other site 572264003009 active site 572264003010 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 572264003011 active site 572264003012 N-terminal domain interface [polypeptide binding]; other site 572264003013 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 572264003014 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572264003015 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572264003016 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 572264003017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 572264003018 Fn3 associated; Region: Fn3_assoc; pfam13287 572264003019 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 572264003020 generic binding surface II; other site 572264003021 generic binding surface I; other site 572264003022 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 572264003023 putative active site [active] 572264003024 putative catalytic site [active] 572264003025 putative Mg binding site IVb [ion binding]; other site 572264003026 putative phosphate binding site [ion binding]; other site 572264003027 putative DNA binding site [nucleotide binding]; other site 572264003028 putative Mg binding site IVa [ion binding]; other site 572264003029 Penicillinase repressor; Region: Pencillinase_R; pfam03965 572264003030 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 572264003031 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 572264003032 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264003033 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264003034 Predicted membrane protein [Function unknown]; Region: COG1511 572264003035 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 572264003036 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 572264003037 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 572264003038 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 572264003039 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 572264003040 DinB superfamily; Region: DinB_2; pfam12867 572264003041 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 572264003042 Predicted transcriptional regulator [Transcription]; Region: COG2378 572264003043 HTH domain; Region: HTH_11; pfam08279 572264003044 WYL domain; Region: WYL; pfam13280 572264003045 Transcriptional regulators [Transcription]; Region: PurR; COG1609 572264003046 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 572264003047 DNA binding site [nucleotide binding] 572264003048 domain linker motif; other site 572264003049 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 572264003050 putative dimerization interface [polypeptide binding]; other site 572264003051 putative ligand binding site [chemical binding]; other site 572264003052 YhfH-like protein; Region: YhfH; pfam14149 572264003053 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 572264003054 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 572264003055 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 572264003056 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 572264003057 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 572264003058 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 572264003059 acyl-activating enzyme (AAE) consensus motif; other site 572264003060 putative AMP binding site [chemical binding]; other site 572264003061 putative active site [active] 572264003062 putative CoA binding site [chemical binding]; other site 572264003063 RHS protein; Region: RHS; pfam03527 572264003064 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 572264003065 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 572264003066 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 572264003067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264003068 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572264003069 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 572264003070 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 572264003071 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 572264003072 putative active site [active] 572264003073 putative metal binding site [ion binding]; other site 572264003074 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572264003075 Zn2+ binding site [ion binding]; other site 572264003076 Mg2+ binding site [ion binding]; other site 572264003077 Putative zinc-finger; Region: zf-HC2; pfam13490 572264003078 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 572264003079 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 572264003080 RNA polymerase sigma factor; Provisional; Region: PRK12541 572264003081 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264003082 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572264003083 DNA binding residues [nucleotide binding] 572264003084 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 572264003085 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 572264003086 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 572264003087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 572264003088 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264003089 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264003090 dimer interface [polypeptide binding]; other site 572264003091 phosphorylation site [posttranslational modification] 572264003092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264003093 ATP binding site [chemical binding]; other site 572264003094 Mg2+ binding site [ion binding]; other site 572264003095 G-X-G motif; other site 572264003096 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264003097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264003098 active site 572264003099 phosphorylation site [posttranslational modification] 572264003100 intermolecular recognition site; other site 572264003101 dimerization interface [polypeptide binding]; other site 572264003102 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264003103 DNA binding site [nucleotide binding] 572264003104 CAAX protease self-immunity; Region: Abi; pfam02517 572264003105 Peptidase family M48; Region: Peptidase_M48; pfam01435 572264003106 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 572264003107 EamA-like transporter family; Region: EamA; pfam00892 572264003108 EamA-like transporter family; Region: EamA; pfam00892 572264003109 S-layer homology domain; Region: SLH; pfam00395 572264003110 S-layer homology domain; Region: SLH; pfam00395 572264003111 S-layer homology domain; Region: SLH; pfam00395 572264003112 S-layer homology domain; Region: SLH; pfam00395 572264003113 S-layer homology domain; Region: SLH; pfam00395 572264003114 S-layer homology domain; Region: SLH; pfam00395 572264003115 S-layer homology domain; Region: SLH; pfam00395 572264003116 S-layer homology domain; Region: SLH; pfam00395 572264003117 S-layer homology domain; Region: SLH; pfam00395 572264003118 malate synthase A; Region: malate_syn_A; TIGR01344 572264003119 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 572264003120 active site 572264003121 isocitrate lyase; Provisional; Region: PRK15063 572264003122 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 572264003123 tetramer interface [polypeptide binding]; other site 572264003124 active site 572264003125 Mg2+/Mn2+ binding site [ion binding]; other site 572264003126 Phosphotransferase enzyme family; Region: APH; pfam01636 572264003127 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 572264003128 active site 572264003129 substrate binding site [chemical binding]; other site 572264003130 ATP binding site [chemical binding]; other site 572264003131 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 572264003132 DNA-binding site [nucleotide binding]; DNA binding site 572264003133 RNA-binding motif; other site 572264003134 ComK protein; Region: ComK; pfam06338 572264003135 Uncharacterized conserved protein [Function unknown]; Region: COG0398 572264003136 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 572264003137 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 572264003138 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 572264003139 Catalytic site [active] 572264003140 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 572264003141 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 572264003142 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 572264003143 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 572264003144 Part of AAA domain; Region: AAA_19; pfam13245 572264003145 Family description; Region: UvrD_C_2; pfam13538 572264003146 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 572264003147 hypothetical protein; Provisional; Region: PRK07758 572264003148 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 572264003149 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 572264003150 Spore germination protein GerPC; Region: GerPC; pfam10737 572264003151 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 572264003152 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 572264003153 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 572264003154 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 572264003155 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 572264003156 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 572264003157 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 572264003158 inhibitor-cofactor binding pocket; inhibition site 572264003159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264003160 catalytic residue [active] 572264003161 hypothetical protein; Provisional; Region: PRK13673 572264003162 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 572264003163 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 572264003164 active site 572264003165 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 572264003166 dimer interface [polypeptide binding]; other site 572264003167 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 572264003168 Ligand Binding Site [chemical binding]; other site 572264003169 Molecular Tunnel; other site 572264003170 ferrochelatase; Provisional; Region: PRK12435 572264003171 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 572264003172 C-terminal domain interface [polypeptide binding]; other site 572264003173 active site 572264003174 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 572264003175 active site 572264003176 N-terminal domain interface [polypeptide binding]; other site 572264003177 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 572264003178 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 572264003179 tetramer interface [polypeptide binding]; other site 572264003180 heme binding pocket [chemical binding]; other site 572264003181 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 572264003182 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 572264003183 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 572264003184 active site 572264003185 catalytic site [active] 572264003186 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264003187 non-specific DNA binding site [nucleotide binding]; other site 572264003188 salt bridge; other site 572264003189 sequence-specific DNA binding site [nucleotide binding]; other site 572264003190 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 572264003191 binding surface 572264003192 TPR motif; other site 572264003193 Tetratricopeptide repeat; Region: TPR_12; pfam13424 572264003194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 572264003195 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 572264003196 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 572264003197 S1 domain; Region: S1_2; pfam13509 572264003198 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 572264003199 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 572264003200 Uncharacterized conserved protein [Function unknown]; Region: COG1284 572264003201 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 572264003202 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 572264003203 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 572264003204 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 572264003205 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264003206 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 572264003207 active site 572264003208 motif I; other site 572264003209 motif II; other site 572264003210 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 572264003211 YjzC-like protein; Region: YjzC; pfam14168 572264003212 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 572264003213 Clp amino terminal domain; Region: Clp_N; pfam02861 572264003214 Clp amino terminal domain; Region: Clp_N; pfam02861 572264003215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264003216 Walker A motif; other site 572264003217 ATP binding site [chemical binding]; other site 572264003218 Walker B motif; other site 572264003219 arginine finger; other site 572264003220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264003221 Walker A motif; other site 572264003222 ATP binding site [chemical binding]; other site 572264003223 Walker B motif; other site 572264003224 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 572264003225 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 572264003226 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 572264003227 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 572264003228 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 572264003229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572264003230 NAD(P) binding site [chemical binding]; other site 572264003231 active site 572264003232 ComZ; Region: ComZ; pfam10815 572264003233 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 572264003234 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 572264003235 dimer interface [polypeptide binding]; other site 572264003236 active site 572264003237 CoA binding pocket [chemical binding]; other site 572264003238 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 572264003239 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 572264003240 dimer interface [polypeptide binding]; other site 572264003241 active site 572264003242 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 572264003243 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 572264003244 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 572264003245 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 572264003246 active site 572264003247 HIGH motif; other site 572264003248 dimer interface [polypeptide binding]; other site 572264003249 KMSKS motif; other site 572264003250 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 572264003251 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 572264003252 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 572264003253 peptide binding site [polypeptide binding]; other site 572264003254 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 572264003255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264003256 dimer interface [polypeptide binding]; other site 572264003257 conserved gate region; other site 572264003258 putative PBP binding loops; other site 572264003259 ABC-ATPase subunit interface; other site 572264003260 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 572264003261 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 572264003262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264003263 dimer interface [polypeptide binding]; other site 572264003264 conserved gate region; other site 572264003265 putative PBP binding loops; other site 572264003266 ABC-ATPase subunit interface; other site 572264003267 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 572264003268 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572264003269 Walker A/P-loop; other site 572264003270 ATP binding site [chemical binding]; other site 572264003271 Q-loop/lid; other site 572264003272 ABC transporter signature motif; other site 572264003273 Walker B; other site 572264003274 D-loop; other site 572264003275 H-loop/switch region; other site 572264003276 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 572264003277 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 572264003278 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572264003279 Walker A/P-loop; other site 572264003280 ATP binding site [chemical binding]; other site 572264003281 Q-loop/lid; other site 572264003282 ABC transporter signature motif; other site 572264003283 Walker B; other site 572264003284 D-loop; other site 572264003285 H-loop/switch region; other site 572264003286 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 572264003287 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 572264003288 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 572264003289 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 572264003290 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 572264003291 peptide binding site [polypeptide binding]; other site 572264003292 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 572264003293 ArsC family; Region: ArsC; pfam03960 572264003294 putative catalytic residues [active] 572264003295 thiol/disulfide switch; other site 572264003296 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 572264003297 adaptor protein; Provisional; Region: PRK02315 572264003298 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 572264003299 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 572264003300 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 572264003301 putative active site [active] 572264003302 catalytic site [active] 572264003303 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 572264003304 putative active site [active] 572264003305 catalytic site [active] 572264003306 Competence protein CoiA-like family; Region: CoiA; cl11541 572264003307 oligoendopeptidase F; Region: pepF; TIGR00181 572264003308 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 572264003309 active site 572264003310 Zn binding site [ion binding]; other site 572264003311 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 572264003312 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 572264003313 catalytic residues [active] 572264003314 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 572264003315 apolar tunnel; other site 572264003316 heme binding site [chemical binding]; other site 572264003317 dimerization interface [polypeptide binding]; other site 572264003318 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 572264003319 putative active site [active] 572264003320 putative metal binding residues [ion binding]; other site 572264003321 signature motif; other site 572264003322 putative triphosphate binding site [ion binding]; other site 572264003323 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 572264003324 synthetase active site [active] 572264003325 NTP binding site [chemical binding]; other site 572264003326 metal binding site [ion binding]; metal-binding site 572264003327 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 572264003328 ATP-NAD kinase; Region: NAD_kinase; pfam01513 572264003329 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 572264003330 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 572264003331 active site 572264003332 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 572264003333 trimer interface [polypeptide binding]; other site 572264003334 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 572264003335 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 572264003336 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 572264003337 active site 572264003338 metal binding site [ion binding]; metal-binding site 572264003339 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 572264003340 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 572264003341 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 572264003342 active site 572264003343 Methyltransferase domain; Region: Methyltransf_23; pfam13489 572264003344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264003345 S-adenosylmethionine binding site [chemical binding]; other site 572264003346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 572264003347 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 572264003348 putative metal binding site; other site 572264003349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264003350 binding surface 572264003351 TPR motif; other site 572264003352 Methyltransferase domain; Region: Methyltransf_23; pfam13489 572264003353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264003354 S-adenosylmethionine binding site [chemical binding]; other site 572264003355 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 572264003356 catalytic residues [active] 572264003357 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 572264003358 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 572264003359 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 572264003360 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 572264003361 active site 572264003362 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 572264003363 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 572264003364 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 572264003365 NAD binding site [chemical binding]; other site 572264003366 substrate binding site [chemical binding]; other site 572264003367 homodimer interface [polypeptide binding]; other site 572264003368 active site 572264003369 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 572264003370 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 572264003371 NADP binding site [chemical binding]; other site 572264003372 active site 572264003373 putative substrate binding site [chemical binding]; other site 572264003374 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 572264003375 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 572264003376 NAD binding site [chemical binding]; other site 572264003377 homotetramer interface [polypeptide binding]; other site 572264003378 homodimer interface [polypeptide binding]; other site 572264003379 substrate binding site [chemical binding]; other site 572264003380 active site 572264003381 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 572264003382 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 572264003383 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 572264003384 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 572264003385 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 572264003386 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 572264003387 Part of AAA domain; Region: AAA_19; pfam13245 572264003388 Family description; Region: UvrD_C_2; pfam13538 572264003389 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 572264003390 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264003391 Coenzyme A binding pocket [chemical binding]; other site 572264003392 hypothetical protein; Provisional; Region: PRK13679 572264003393 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 572264003394 Putative esterase; Region: Esterase; pfam00756 572264003395 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 572264003396 EamA-like transporter family; Region: EamA; pfam00892 572264003397 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 572264003398 EamA-like transporter family; Region: EamA; pfam00892 572264003399 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 572264003400 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 572264003401 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 572264003402 Na binding site [ion binding]; other site 572264003403 anthranilate synthase component I; Provisional; Region: PRK13570 572264003404 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 572264003405 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 572264003406 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 572264003407 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 572264003408 glutamine binding [chemical binding]; other site 572264003409 catalytic triad [active] 572264003410 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 572264003411 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 572264003412 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 572264003413 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 572264003414 active site 572264003415 ribulose/triose binding site [chemical binding]; other site 572264003416 phosphate binding site [ion binding]; other site 572264003417 substrate (anthranilate) binding pocket [chemical binding]; other site 572264003418 product (indole) binding pocket [chemical binding]; other site 572264003419 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 572264003420 active site 572264003421 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 572264003422 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 572264003423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264003424 catalytic residue [active] 572264003425 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 572264003426 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 572264003427 substrate binding site [chemical binding]; other site 572264003428 active site 572264003429 catalytic residues [active] 572264003430 heterodimer interface [polypeptide binding]; other site 572264003431 Protein of unknown function (DUF4029); Region: DUF4029; pfam13221 572264003432 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 572264003433 L-lactate permease; Region: Lactate_perm; cl00701 572264003434 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 572264003435 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 572264003436 Double zinc ribbon; Region: DZR; pfam12773 572264003437 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572264003438 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 572264003439 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572264003440 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 572264003441 Predicted acetyltransferase [General function prediction only]; Region: COG5628 572264003442 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 572264003443 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 572264003444 NADPH bind site [chemical binding]; other site 572264003445 putative FMN binding site [chemical binding]; other site 572264003446 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 572264003447 putative FMN binding site [chemical binding]; other site 572264003448 NADPH bind site [chemical binding]; other site 572264003449 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 572264003450 YcaO-like family; Region: YcaO; pfam02624 572264003451 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 572264003452 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 572264003453 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 572264003454 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 572264003455 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 572264003456 E3 interaction surface; other site 572264003457 lipoyl attachment site [posttranslational modification]; other site 572264003458 e3 binding domain; Region: E3_binding; pfam02817 572264003459 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 572264003460 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 572264003461 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 572264003462 TPP-binding site [chemical binding]; other site 572264003463 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 572264003464 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264003465 salt bridge; other site 572264003466 non-specific DNA binding site [nucleotide binding]; other site 572264003467 sequence-specific DNA binding site [nucleotide binding]; other site 572264003468 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 572264003469 Predicted transcriptional regulators [Transcription]; Region: COG1695 572264003470 Transcriptional regulator PadR-like family; Region: PadR; cl17335 572264003471 Methyltransferase domain; Region: Methyltransf_23; pfam13489 572264003472 Methyltransferase domain; Region: Methyltransf_25; pfam13649 572264003473 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 572264003474 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 572264003475 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572264003476 catalytic residue [active] 572264003477 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 572264003478 classical (c) SDRs; Region: SDR_c; cd05233 572264003479 NAD(P) binding site [chemical binding]; other site 572264003480 active site 572264003481 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 572264003482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264003483 Walker A/P-loop; other site 572264003484 ATP binding site [chemical binding]; other site 572264003485 Q-loop/lid; other site 572264003486 ABC transporter signature motif; other site 572264003487 Walker B; other site 572264003488 D-loop; other site 572264003489 H-loop/switch region; other site 572264003490 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 572264003491 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 572264003492 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 572264003493 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 572264003494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264003495 S-adenosylmethionine binding site [chemical binding]; other site 572264003496 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 572264003497 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 572264003498 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 572264003499 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 572264003500 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 572264003501 Catalytic site [active] 572264003502 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 572264003503 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 572264003504 Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389 572264003505 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572264003506 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264003507 non-specific DNA binding site [nucleotide binding]; other site 572264003508 salt bridge; other site 572264003509 sequence-specific DNA binding site [nucleotide binding]; other site 572264003510 Anti-repressor SinI; Region: SinI; pfam08671 572264003511 Anti-repressor SinI; Region: SinI; pfam08671 572264003512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 572264003513 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 572264003514 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 572264003515 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 572264003516 NAD(P) binding site [chemical binding]; other site 572264003517 catalytic residues [active] 572264003518 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 572264003519 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 572264003520 Walker A/P-loop; other site 572264003521 ATP binding site [chemical binding]; other site 572264003522 Q-loop/lid; other site 572264003523 ABC transporter signature motif; other site 572264003524 Walker B; other site 572264003525 D-loop; other site 572264003526 H-loop/switch region; other site 572264003527 TOBE domain; Region: TOBE_2; pfam08402 572264003528 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 572264003529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264003530 dimer interface [polypeptide binding]; other site 572264003531 conserved gate region; other site 572264003532 putative PBP binding loops; other site 572264003533 ABC-ATPase subunit interface; other site 572264003534 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 572264003535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264003536 dimer interface [polypeptide binding]; other site 572264003537 conserved gate region; other site 572264003538 putative PBP binding loops; other site 572264003539 ABC-ATPase subunit interface; other site 572264003540 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 572264003541 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 572264003542 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 572264003543 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 572264003544 active site 572264003545 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 572264003546 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 572264003547 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 572264003548 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 572264003549 active site 572264003550 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 572264003551 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 572264003552 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 572264003553 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 572264003554 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 572264003555 Cysteine-rich domain; Region: CCG; pfam02754 572264003556 Cysteine-rich domain; Region: CCG; pfam02754 572264003557 FAD binding domain; Region: FAD_binding_4; pfam01565 572264003558 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 572264003559 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 572264003560 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 572264003561 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 572264003562 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 572264003563 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 572264003564 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264003565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264003566 active site 572264003567 phosphorylation site [posttranslational modification] 572264003568 intermolecular recognition site; other site 572264003569 dimerization interface [polypeptide binding]; other site 572264003570 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264003571 DNA binding site [nucleotide binding] 572264003572 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 572264003573 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264003574 dimerization interface [polypeptide binding]; other site 572264003575 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264003576 dimer interface [polypeptide binding]; other site 572264003577 phosphorylation site [posttranslational modification] 572264003578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264003579 ATP binding site [chemical binding]; other site 572264003580 Mg2+ binding site [ion binding]; other site 572264003581 G-X-G motif; other site 572264003582 Transcriptional regulators [Transcription]; Region: FadR; COG2186 572264003583 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572264003584 DNA-binding site [nucleotide binding]; DNA binding site 572264003585 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 572264003586 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 572264003587 Cysteine-rich domain; Region: CCG; pfam02754 572264003588 Cysteine-rich domain; Region: CCG; pfam02754 572264003589 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 572264003590 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 572264003591 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 572264003592 Uncharacterized conserved protein [Function unknown]; Region: COG1556 572264003593 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 572264003594 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 572264003595 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 572264003596 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 572264003597 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 572264003598 yybP-ykoY leader 572264003599 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 572264003600 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 572264003601 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 572264003602 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 572264003603 dimer interaction site [polypeptide binding]; other site 572264003604 substrate-binding tunnel; other site 572264003605 active site 572264003606 catalytic site [active] 572264003607 substrate binding site [chemical binding]; other site 572264003608 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 572264003609 poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719 572264003610 Predicted transcriptional regulators [Transcription]; Region: COG1695 572264003611 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 572264003612 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 572264003613 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 572264003614 NAD(P) binding site [chemical binding]; other site 572264003615 homotetramer interface [polypeptide binding]; other site 572264003616 homodimer interface [polypeptide binding]; other site 572264003617 active site 572264003618 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 572264003619 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 572264003620 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 572264003621 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 572264003622 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 572264003623 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 572264003624 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 572264003625 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 572264003626 putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261 572264003627 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 572264003628 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 572264003629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264003630 dimer interface [polypeptide binding]; other site 572264003631 conserved gate region; other site 572264003632 putative PBP binding loops; other site 572264003633 ABC-ATPase subunit interface; other site 572264003634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264003635 dimer interface [polypeptide binding]; other site 572264003636 conserved gate region; other site 572264003637 putative PBP binding loops; other site 572264003638 ABC-ATPase subunit interface; other site 572264003639 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 572264003640 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264003641 motif II; other site 572264003642 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 572264003643 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572264003644 catalytic residue [active] 572264003645 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 572264003646 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 572264003647 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 572264003648 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 572264003649 hypothetical protein; Validated; Region: PRK06755 572264003650 intersubunit interface [polypeptide binding]; other site 572264003651 active site 572264003652 Zn2+ binding site [ion binding]; other site 572264003653 FOG: CBS domain [General function prediction only]; Region: COG0517 572264003654 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 572264003655 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 572264003656 NodB motif; other site 572264003657 putative active site [active] 572264003658 putative catalytic site [active] 572264003659 Zn binding site [ion binding]; other site 572264003660 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 572264003661 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 572264003662 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264003663 dimer interface [polypeptide binding]; other site 572264003664 phosphorylation site [posttranslational modification] 572264003665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264003666 ATP binding site [chemical binding]; other site 572264003667 Mg2+ binding site [ion binding]; other site 572264003668 G-X-G motif; other site 572264003669 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 572264003670 MarR family; Region: MarR; pfam01047 572264003671 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 572264003672 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 572264003673 active site 572264003674 Zn binding site [ion binding]; other site 572264003675 DinB superfamily; Region: DinB_2; pfam12867 572264003676 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 572264003677 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264003678 dimer interface [polypeptide binding]; other site 572264003679 phosphorylation site [posttranslational modification] 572264003680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264003681 ATP binding site [chemical binding]; other site 572264003682 Mg2+ binding site [ion binding]; other site 572264003683 G-X-G motif; other site 572264003684 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 572264003685 Ligand Binding Site [chemical binding]; other site 572264003686 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 572264003687 active site 572264003688 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 572264003689 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 572264003690 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 572264003691 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 572264003692 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 572264003693 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264003694 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 572264003695 Coenzyme A binding pocket [chemical binding]; other site 572264003696 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 572264003697 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 572264003698 Class I ribonucleotide reductase; Region: RNR_I; cd01679 572264003699 active site 572264003700 dimer interface [polypeptide binding]; other site 572264003701 catalytic residues [active] 572264003702 effector binding site; other site 572264003703 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 572264003704 active site 572264003705 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 572264003706 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 572264003707 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 572264003708 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 572264003709 dimer interface [polypeptide binding]; other site 572264003710 putative radical transfer pathway; other site 572264003711 diiron center [ion binding]; other site 572264003712 tyrosyl radical; other site 572264003713 Predicted transcriptional regulators [Transcription]; Region: COG1725 572264003714 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572264003715 DNA-binding site [nucleotide binding]; DNA binding site 572264003716 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 572264003717 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 572264003718 Walker A/P-loop; other site 572264003719 ATP binding site [chemical binding]; other site 572264003720 Q-loop/lid; other site 572264003721 ABC transporter signature motif; other site 572264003722 Walker B; other site 572264003723 D-loop; other site 572264003724 H-loop/switch region; other site 572264003725 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 572264003726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264003727 Walker A/P-loop; other site 572264003728 ATP binding site [chemical binding]; other site 572264003729 Q-loop/lid; other site 572264003730 ABC transporter signature motif; other site 572264003731 Walker B; other site 572264003732 D-loop; other site 572264003733 H-loop/switch region; other site 572264003734 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 572264003735 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 572264003736 CAAX protease self-immunity; Region: Abi; pfam02517 572264003737 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 572264003738 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 572264003739 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 572264003740 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264003741 putative DNA binding site [nucleotide binding]; other site 572264003742 putative Zn2+ binding site [ion binding]; other site 572264003743 AsnC family; Region: AsnC_trans_reg; pfam01037 572264003744 Uncharacterized conserved protein [Function unknown]; Region: COG2128 572264003745 Isochorismatase family; Region: Isochorismatase; pfam00857 572264003746 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 572264003747 catalytic triad [active] 572264003748 conserved cis-peptide bond; other site 572264003749 SseB protein; Region: SseB; cl06279 572264003750 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 572264003751 dimer interface [polypeptide binding]; other site 572264003752 catalytic triad [active] 572264003753 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 572264003754 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 572264003755 FMN binding site [chemical binding]; other site 572264003756 substrate binding site [chemical binding]; other site 572264003757 putative catalytic residue [active] 572264003758 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 572264003759 DltD N-terminal region; Region: DltD_N; pfam04915 572264003760 DltD central region; Region: DltD_M; pfam04918 572264003761 DltD C-terminal region; Region: DltD_C; pfam04914 572264003762 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 572264003763 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 572264003764 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 572264003765 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 572264003766 acyl-activating enzyme (AAE) consensus motif; other site 572264003767 AMP binding site [chemical binding]; other site 572264003768 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 572264003769 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 572264003770 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 572264003771 metal binding site [ion binding]; metal-binding site 572264003772 dimer interface [polypeptide binding]; other site 572264003773 flavodoxin; Provisional; Region: PRK06756 572264003774 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 572264003775 Phosphotransferase enzyme family; Region: APH; pfam01636 572264003776 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 572264003777 active site 572264003778 substrate binding site [chemical binding]; other site 572264003779 ATP binding site [chemical binding]; other site 572264003780 Wnt and FGF inhibitory regulator; Region: Shisa; pfam13908 572264003781 multidrug efflux protein; Reviewed; Region: PRK01766 572264003782 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 572264003783 cation binding site [ion binding]; other site 572264003784 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 572264003785 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 572264003786 catalytic residues [active] 572264003787 Regulatory protein YrvL; Region: YrvL; pfam14184 572264003788 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 572264003789 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 572264003790 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 572264003791 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 572264003792 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 572264003793 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 572264003794 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 572264003795 hypothetical protein; Provisional; Region: PRK03094 572264003796 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 572264003797 flavin-containing monooxygenase FMO GS-OX; Region: PLN02172 572264003798 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 572264003799 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 572264003800 homodimer interface [polypeptide binding]; other site 572264003801 substrate-cofactor binding pocket; other site 572264003802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264003803 catalytic residue [active] 572264003804 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 572264003805 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 572264003806 PYR/PP interface [polypeptide binding]; other site 572264003807 dimer interface [polypeptide binding]; other site 572264003808 TPP binding site [chemical binding]; other site 572264003809 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 572264003810 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 572264003811 TPP-binding site [chemical binding]; other site 572264003812 dimer interface [polypeptide binding]; other site 572264003813 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 572264003814 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 572264003815 putative valine binding site [chemical binding]; other site 572264003816 dimer interface [polypeptide binding]; other site 572264003817 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 572264003818 ketol-acid reductoisomerase; Provisional; Region: PRK05479 572264003819 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 572264003820 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 572264003821 2-isopropylmalate synthase; Validated; Region: PRK00915 572264003822 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 572264003823 active site 572264003824 catalytic residues [active] 572264003825 metal binding site [ion binding]; metal-binding site 572264003826 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 572264003827 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 572264003828 tartrate dehydrogenase; Region: TTC; TIGR02089 572264003829 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 572264003830 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 572264003831 substrate binding site [chemical binding]; other site 572264003832 ligand binding site [chemical binding]; other site 572264003833 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 572264003834 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 572264003835 substrate binding site [chemical binding]; other site 572264003836 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 572264003837 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 572264003838 dimer interface [polypeptide binding]; other site 572264003839 motif 1; other site 572264003840 active site 572264003841 motif 2; other site 572264003842 motif 3; other site 572264003843 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 572264003844 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 572264003845 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 572264003846 histidinol dehydrogenase; Region: hisD; TIGR00069 572264003847 NAD binding site [chemical binding]; other site 572264003848 dimerization interface [polypeptide binding]; other site 572264003849 product binding site; other site 572264003850 substrate binding site [chemical binding]; other site 572264003851 zinc binding site [ion binding]; other site 572264003852 catalytic residues [active] 572264003853 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 572264003854 putative active site pocket [active] 572264003855 4-fold oligomerization interface [polypeptide binding]; other site 572264003856 metal binding residues [ion binding]; metal-binding site 572264003857 3-fold/trimer interface [polypeptide binding]; other site 572264003858 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 572264003859 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 572264003860 putative active site [active] 572264003861 oxyanion strand; other site 572264003862 catalytic triad [active] 572264003863 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 572264003864 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 572264003865 catalytic residues [active] 572264003866 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 572264003867 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 572264003868 substrate binding site [chemical binding]; other site 572264003869 glutamase interaction surface [polypeptide binding]; other site 572264003870 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 572264003871 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 572264003872 metal binding site [ion binding]; metal-binding site 572264003873 histidinol-phosphatase; Validated; Region: PRK06740 572264003874 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 572264003875 dimer interface [polypeptide binding]; other site 572264003876 active site 572264003877 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 572264003878 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 572264003879 putative ligand binding site [chemical binding]; other site 572264003880 putative NAD binding site [chemical binding]; other site 572264003881 catalytic site [active] 572264003882 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 572264003883 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 572264003884 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 572264003885 Sulfatase; Region: Sulfatase; pfam00884 572264003886 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 572264003887 Lysine riboswitch 572264003888 diaminopimelate decarboxylase; Region: lysA; TIGR01048 572264003889 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 572264003890 active site 572264003891 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 572264003892 substrate binding site [chemical binding]; other site 572264003893 catalytic residues [active] 572264003894 dimer interface [polypeptide binding]; other site 572264003895 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 572264003896 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 572264003897 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 572264003898 Active Sites [active] 572264003899 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 572264003900 ATP-sulfurylase; Region: ATPS; cd00517 572264003901 active site 572264003902 HXXH motif; other site 572264003903 flexible loop; other site 572264003904 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 572264003905 ligand-binding site [chemical binding]; other site 572264003906 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 572264003907 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 572264003908 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 572264003909 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 572264003910 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 572264003911 diphthine synthase; Region: dph5; TIGR00522 572264003912 active site 572264003913 SAM binding site [chemical binding]; other site 572264003914 homodimer interface [polypeptide binding]; other site 572264003915 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 572264003916 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 572264003917 putative active site [active] 572264003918 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 572264003919 putative active site [active] 572264003920 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 572264003921 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 572264003922 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 572264003923 Na2 binding site [ion binding]; other site 572264003924 putative substrate binding site 1 [chemical binding]; other site 572264003925 Na binding site 1 [ion binding]; other site 572264003926 putative substrate binding site 2 [chemical binding]; other site 572264003927 HTH-like domain; Region: HTH_21; pfam13276 572264003928 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 572264003929 Integrase core domain; Region: rve; pfam00665 572264003930 Integrase core domain; Region: rve_2; pfam13333 572264003931 Transposase; Region: HTH_Tnp_1; cl17663 572264003932 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 572264003933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 572264003934 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 572264003935 Peptidase family M23; Region: Peptidase_M23; pfam01551 572264003936 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 572264003937 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 572264003938 Protein of unknown function (DUF402); Region: DUF402; cl00979 572264003939 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 572264003940 Vpu protein; Region: Vpu; pfam00558 572264003941 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 572264003942 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 572264003943 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 572264003944 Histidine kinase; Region: HisKA_3; pfam07730 572264003945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264003946 ATP binding site [chemical binding]; other site 572264003947 Mg2+ binding site [ion binding]; other site 572264003948 G-X-G motif; other site 572264003949 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 572264003950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264003951 active site 572264003952 phosphorylation site [posttranslational modification] 572264003953 intermolecular recognition site; other site 572264003954 dimerization interface [polypeptide binding]; other site 572264003955 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572264003956 DNA binding residues [nucleotide binding] 572264003957 dimerization interface [polypeptide binding]; other site 572264003958 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 572264003959 E3 interaction surface; other site 572264003960 lipoyl attachment site [posttranslational modification]; other site 572264003961 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 572264003962 Methyltransferase domain; Region: Methyltransf_31; pfam13847 572264003963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264003964 S-adenosylmethionine binding site [chemical binding]; other site 572264003965 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 572264003966 Peptidase family M50; Region: Peptidase_M50; pfam02163 572264003967 active site 572264003968 putative substrate binding region [chemical binding]; other site 572264003969 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 572264003970 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 572264003971 heme-binding site [chemical binding]; other site 572264003972 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 572264003973 FAD binding pocket [chemical binding]; other site 572264003974 FAD binding motif [chemical binding]; other site 572264003975 phosphate binding motif [ion binding]; other site 572264003976 beta-alpha-beta structure motif; other site 572264003977 NAD binding pocket [chemical binding]; other site 572264003978 Heme binding pocket [chemical binding]; other site 572264003979 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 572264003980 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 572264003981 ligand binding site [chemical binding]; other site 572264003982 flexible hinge region; other site 572264003983 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 572264003984 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 572264003985 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 572264003986 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 572264003987 Transglycosylase; Region: Transgly; pfam00912 572264003988 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 572264003989 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572264003990 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 572264003991 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 572264003992 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572264003993 putative active site [active] 572264003994 heme pocket [chemical binding]; other site 572264003995 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264003996 dimer interface [polypeptide binding]; other site 572264003997 phosphorylation site [posttranslational modification] 572264003998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264003999 ATP binding site [chemical binding]; other site 572264004000 Mg2+ binding site [ion binding]; other site 572264004001 G-X-G motif; other site 572264004002 Protein of unknown function DUF72; Region: DUF72; pfam01904 572264004003 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 572264004004 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 572264004005 active site 572264004006 DNA binding site [nucleotide binding] 572264004007 Int/Topo IB signature motif; other site 572264004008 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264004009 dimerization interface [polypeptide binding]; other site 572264004010 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264004011 dimer interface [polypeptide binding]; other site 572264004012 phosphorylation site [posttranslational modification] 572264004013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264004014 ATP binding site [chemical binding]; other site 572264004015 Mg2+ binding site [ion binding]; other site 572264004016 G-X-G motif; other site 572264004017 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 572264004018 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 572264004019 Probable transposase; Region: OrfB_IS605; pfam01385 572264004020 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 572264004021 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 572264004022 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 572264004023 Predicted integral membrane protein [Function unknown]; Region: COG0392 572264004024 Uncharacterized conserved protein [Function unknown]; Region: COG2898 572264004025 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 572264004026 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 572264004027 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 572264004028 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 572264004029 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 572264004030 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 572264004031 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 572264004032 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 572264004033 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 572264004034 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 572264004035 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572264004036 RNA binding surface [nucleotide binding]; other site 572264004037 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 572264004038 active site 572264004039 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 572264004040 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 572264004041 catalytic residues [active] 572264004042 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 572264004043 ResB-like family; Region: ResB; pfam05140 572264004044 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 572264004045 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 572264004046 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264004047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264004048 active site 572264004049 phosphorylation site [posttranslational modification] 572264004050 intermolecular recognition site; other site 572264004051 dimerization interface [polypeptide binding]; other site 572264004052 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264004053 DNA binding site [nucleotide binding] 572264004054 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 572264004055 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264004056 dimerization interface [polypeptide binding]; other site 572264004057 PAS domain; Region: PAS; smart00091 572264004058 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264004059 dimer interface [polypeptide binding]; other site 572264004060 phosphorylation site [posttranslational modification] 572264004061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264004062 ATP binding site [chemical binding]; other site 572264004063 Mg2+ binding site [ion binding]; other site 572264004064 G-X-G motif; other site 572264004065 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 572264004066 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 572264004067 Peptidase family M23; Region: Peptidase_M23; pfam01551 572264004068 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 572264004069 Predicted membrane protein [Function unknown]; Region: COG3601 572264004070 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 572264004071 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 572264004072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 572264004073 DEAD-like helicases superfamily; Region: DEXDc; smart00487 572264004074 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572264004075 ATP binding site [chemical binding]; other site 572264004076 putative Mg++ binding site [ion binding]; other site 572264004077 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572264004078 nucleotide binding region [chemical binding]; other site 572264004079 ATP-binding site [chemical binding]; other site 572264004080 CAAX protease self-immunity; Region: Abi; pfam02517 572264004081 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 572264004082 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 572264004083 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 572264004084 putative active site [active] 572264004085 putative metal binding site [ion binding]; other site 572264004086 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 572264004087 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 572264004088 DNA binding residues [nucleotide binding] 572264004089 B12 binding domain; Region: B12-binding_2; pfam02607 572264004090 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 572264004091 adaptor protein; Provisional; Region: PRK02899 572264004092 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 572264004093 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 572264004094 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 572264004095 NAD(P) binding site [chemical binding]; other site 572264004096 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 572264004097 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 572264004098 amidase catalytic site [active] 572264004099 Zn binding residues [ion binding]; other site 572264004100 substrate binding site [chemical binding]; other site 572264004101 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 572264004102 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 572264004103 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572264004104 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 572264004105 active site 572264004106 homotetramer interface [polypeptide binding]; other site 572264004107 homodimer interface [polypeptide binding]; other site 572264004108 cytidylate kinase; Provisional; Region: cmk; PRK00023 572264004109 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 572264004110 CMP-binding site; other site 572264004111 The sites determining sugar specificity; other site 572264004112 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 572264004113 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 572264004114 RNA binding site [nucleotide binding]; other site 572264004115 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 572264004116 RNA binding site [nucleotide binding]; other site 572264004117 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 572264004118 RNA binding site [nucleotide binding]; other site 572264004119 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 572264004120 RNA binding site [nucleotide binding]; other site 572264004121 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 572264004122 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 572264004123 homotetramer interface [polypeptide binding]; other site 572264004124 FMN binding site [chemical binding]; other site 572264004125 homodimer contacts [polypeptide binding]; other site 572264004126 putative active site [active] 572264004127 putative substrate binding site [chemical binding]; other site 572264004128 YpzI-like protein; Region: YpzI; pfam14140 572264004129 YIEGIA protein; Region: YIEGIA; pfam14045 572264004130 GTP-binding protein Der; Reviewed; Region: PRK00093 572264004131 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 572264004132 G1 box; other site 572264004133 GTP/Mg2+ binding site [chemical binding]; other site 572264004134 Switch I region; other site 572264004135 G2 box; other site 572264004136 Switch II region; other site 572264004137 G3 box; other site 572264004138 G4 box; other site 572264004139 G5 box; other site 572264004140 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 572264004141 G1 box; other site 572264004142 GTP/Mg2+ binding site [chemical binding]; other site 572264004143 Switch I region; other site 572264004144 G2 box; other site 572264004145 G3 box; other site 572264004146 Switch II region; other site 572264004147 G4 box; other site 572264004148 G5 box; other site 572264004149 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 572264004150 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 572264004151 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 572264004152 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 572264004153 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 572264004154 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 572264004155 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 572264004156 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 572264004157 IHF dimer interface [polypeptide binding]; other site 572264004158 IHF - DNA interface [nucleotide binding]; other site 572264004159 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 572264004160 homodecamer interface [polypeptide binding]; other site 572264004161 GTP cyclohydrolase I; Provisional; Region: PLN03044 572264004162 active site 572264004163 putative catalytic site residues [active] 572264004164 zinc binding site [ion binding]; other site 572264004165 GTP-CH-I/GFRP interaction surface; other site 572264004166 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 572264004167 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 572264004168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264004169 S-adenosylmethionine binding site [chemical binding]; other site 572264004170 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 572264004171 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 572264004172 substrate binding pocket [chemical binding]; other site 572264004173 chain length determination region; other site 572264004174 substrate-Mg2+ binding site; other site 572264004175 catalytic residues [active] 572264004176 aspartate-rich region 1; other site 572264004177 active site lid residues [active] 572264004178 aspartate-rich region 2; other site 572264004179 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 572264004180 active site 572264004181 multimer interface [polypeptide binding]; other site 572264004182 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 572264004183 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 572264004184 Tetramer interface [polypeptide binding]; other site 572264004185 active site 572264004186 FMN-binding site [chemical binding]; other site 572264004187 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 572264004188 active site 572264004189 dimer interface [polypeptide binding]; other site 572264004190 metal binding site [ion binding]; metal-binding site 572264004191 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 572264004192 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572264004193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264004194 homodimer interface [polypeptide binding]; other site 572264004195 catalytic residue [active] 572264004196 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 572264004197 TPR motif; other site 572264004198 binding surface 572264004199 Tetratricopeptide repeat; Region: TPR_12; pfam13424 572264004200 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264004201 binding surface 572264004202 TPR motif; other site 572264004203 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 572264004204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264004205 binding surface 572264004206 TPR motif; other site 572264004207 Tetratricopeptide repeat; Region: TPR_12; pfam13424 572264004208 TPR repeat; Region: TPR_11; pfam13414 572264004209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264004210 binding surface 572264004211 TPR motif; other site 572264004212 hypothetical protein; Provisional; Region: PRK03636 572264004213 UPF0302 domain; Region: UPF0302; pfam08864 572264004214 IDEAL domain; Region: IDEAL; pfam08858 572264004215 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 572264004216 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 572264004217 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 572264004218 iron-sulfur cluster [ion binding]; other site 572264004219 [2Fe-2S] cluster binding site [ion binding]; other site 572264004220 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 572264004221 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 572264004222 interchain domain interface [polypeptide binding]; other site 572264004223 intrachain domain interface; other site 572264004224 heme bH binding site [chemical binding]; other site 572264004225 Qi binding site; other site 572264004226 heme bL binding site [chemical binding]; other site 572264004227 Qo binding site; other site 572264004228 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 572264004229 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 572264004230 interchain domain interface [polypeptide binding]; other site 572264004231 intrachain domain interface; other site 572264004232 Qi binding site; other site 572264004233 Qo binding site; other site 572264004234 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 572264004235 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 572264004236 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 572264004237 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 572264004238 sporulation protein YpjB; Region: spore_ypjB; TIGR02878 572264004239 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 572264004240 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 572264004241 active site 572264004242 Fe-S cluster binding site [ion binding]; other site 572264004243 Uncharacterized conserved protein [Function unknown]; Region: COG1284 572264004244 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 572264004245 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 572264004246 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 572264004247 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 572264004248 homodimer interface [polypeptide binding]; other site 572264004249 metal binding site [ion binding]; metal-binding site 572264004250 dihydrodipicolinate reductase; Provisional; Region: PRK00048 572264004251 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 572264004252 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 572264004253 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 572264004254 active site 572264004255 dimer interfaces [polypeptide binding]; other site 572264004256 catalytic residues [active] 572264004257 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 572264004258 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 572264004259 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 572264004260 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 572264004261 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 572264004262 active site 572264004263 NTP binding site [chemical binding]; other site 572264004264 metal binding triad [ion binding]; metal-binding site 572264004265 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 572264004266 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 572264004267 Biotin operon repressor [Transcription]; Region: BirA; COG1654 572264004268 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 572264004269 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 572264004270 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 572264004271 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 572264004272 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 572264004273 oligomerization interface [polypeptide binding]; other site 572264004274 active site 572264004275 metal binding site [ion binding]; metal-binding site 572264004276 pantoate--beta-alanine ligase; Region: panC; TIGR00018 572264004277 Pantoate-beta-alanine ligase; Region: PanC; cd00560 572264004278 active site 572264004279 ATP-binding site [chemical binding]; other site 572264004280 pantoate-binding site; other site 572264004281 HXXH motif; other site 572264004282 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 572264004283 tetramerization interface [polypeptide binding]; other site 572264004284 active site 572264004285 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 572264004286 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 572264004287 active site 572264004288 catalytic site [active] 572264004289 substrate binding site [chemical binding]; other site 572264004290 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 572264004291 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572264004292 nucleotide binding region [chemical binding]; other site 572264004293 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 572264004294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 572264004295 aspartate aminotransferase; Provisional; Region: PRK05764 572264004296 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572264004297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264004298 homodimer interface [polypeptide binding]; other site 572264004299 catalytic residue [active] 572264004300 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 572264004301 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 572264004302 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 572264004303 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 572264004304 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 572264004305 minor groove reading motif; other site 572264004306 helix-hairpin-helix signature motif; other site 572264004307 substrate binding pocket [chemical binding]; other site 572264004308 active site 572264004309 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 572264004310 Transglycosylase; Region: Transgly; pfam00912 572264004311 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 572264004312 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 572264004313 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 572264004314 Interdomain contacts; other site 572264004315 Cytokine receptor motif; other site 572264004316 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 572264004317 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 572264004318 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 572264004319 YppF-like protein; Region: YppF; pfam14178 572264004320 YppG-like protein; Region: YppG; pfam14179 572264004321 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 572264004322 hypothetical protein; Provisional; Region: PRK13660 572264004323 cell division protein GpsB; Provisional; Region: PRK14127 572264004324 DivIVA domain; Region: DivI1A_domain; TIGR03544 572264004325 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 572264004326 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 572264004327 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 572264004328 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 572264004329 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 572264004330 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 572264004331 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 572264004332 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 572264004333 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 572264004334 active site 572264004335 Zn binding site [ion binding]; other site 572264004336 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572264004337 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 572264004338 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 572264004339 Phosphotransferase enzyme family; Region: APH; pfam01636 572264004340 putative active site [active] 572264004341 putative substrate binding site [chemical binding]; other site 572264004342 ATP binding site [chemical binding]; other site 572264004343 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 572264004344 active site 572264004345 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572264004346 active site 572264004347 xanthine permease; Region: pbuX; TIGR03173 572264004348 Predicted membrane protein [Function unknown]; Region: COG2311 572264004349 Protein of unknown function (DUF418); Region: DUF418; cl12135 572264004350 Protein of unknown function (DUF418); Region: DUF418; pfam04235 572264004351 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 572264004352 Dynamin family; Region: Dynamin_N; pfam00350 572264004353 G1 box; other site 572264004354 GTP/Mg2+ binding site [chemical binding]; other site 572264004355 G2 box; other site 572264004356 Switch I region; other site 572264004357 G3 box; other site 572264004358 Switch II region; other site 572264004359 G4 box; other site 572264004360 G5 box; other site 572264004361 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 572264004362 Dynamin family; Region: Dynamin_N; pfam00350 572264004363 G1 box; other site 572264004364 GTP/Mg2+ binding site [chemical binding]; other site 572264004365 G2 box; other site 572264004366 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 572264004367 G3 box; other site 572264004368 Switch II region; other site 572264004369 GTP/Mg2+ binding site [chemical binding]; other site 572264004370 G4 box; other site 572264004371 G5 box; other site 572264004372 Protein of unknown function (DUF3931); Region: DUF3931; pfam13082 572264004373 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264004374 Coenzyme A binding pocket [chemical binding]; other site 572264004375 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 572264004376 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 572264004377 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 572264004378 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 572264004379 active site residue [active] 572264004380 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 572264004381 active site residue [active] 572264004382 Probable transposase; Region: OrfB_IS605; pfam01385 572264004383 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 572264004384 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 572264004385 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 572264004386 Predicted membrane protein [Function unknown]; Region: COG3766 572264004387 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 572264004388 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 572264004389 ykoK leader 572264004390 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 572264004391 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572264004392 5'-3' exonuclease; Region: 53EXOc; smart00475 572264004393 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 572264004394 active site 572264004395 metal binding site 1 [ion binding]; metal-binding site 572264004396 putative 5' ssDNA interaction site; other site 572264004397 metal binding site 3; metal-binding site 572264004398 metal binding site 2 [ion binding]; metal-binding site 572264004399 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 572264004400 putative DNA binding site [nucleotide binding]; other site 572264004401 putative metal binding site [ion binding]; other site 572264004402 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 572264004403 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004404 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004405 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004406 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004407 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004408 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004409 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004410 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004411 Domain of unknown function DUF11; Region: DUF11; cl17728 572264004412 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004413 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004414 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004415 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004416 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004417 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004418 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004419 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004420 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004421 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004422 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004423 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004424 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004425 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004426 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004427 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004428 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004429 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004430 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004431 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264004432 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 572264004433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264004434 Coenzyme A binding pocket [chemical binding]; other site 572264004435 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 572264004436 Isochorismatase family; Region: Isochorismatase; pfam00857 572264004437 catalytic triad [active] 572264004438 conserved cis-peptide bond; other site 572264004439 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 572264004440 EamA-like transporter family; Region: EamA; pfam00892 572264004441 EamA-like transporter family; Region: EamA; cl17759 572264004442 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 572264004443 RNA/DNA hybrid binding site [nucleotide binding]; other site 572264004444 active site 572264004445 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 572264004446 active site 572264004447 catalytic residues [active] 572264004448 QueT transporter; Region: QueT; pfam06177 572264004449 hypothetical protein; Validated; Region: PRK07708 572264004450 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 572264004451 RNA/DNA hybrid binding site [nucleotide binding]; other site 572264004452 active site 572264004453 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 572264004454 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 572264004455 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 572264004456 DNA-binding site [nucleotide binding]; DNA binding site 572264004457 RNA-binding motif; other site 572264004458 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 572264004459 LysE type translocator; Region: LysE; pfam01810 572264004460 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 572264004461 Protein of unknown function, DUF485; Region: DUF485; pfam04341 572264004462 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 572264004463 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 572264004464 Na binding site [ion binding]; other site 572264004465 aminotransferase; Validated; Region: PRK07678 572264004466 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 572264004467 inhibitor-cofactor binding pocket; inhibition site 572264004468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264004469 catalytic residue [active] 572264004470 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 572264004471 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 572264004472 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 572264004473 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 572264004474 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572264004475 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 572264004476 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 572264004477 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 572264004478 DNA binding residues [nucleotide binding] 572264004479 drug binding residues [chemical binding]; other site 572264004480 dimer interface [polypeptide binding]; other site 572264004481 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 572264004482 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 572264004483 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 572264004484 Predicted membrane protein [Function unknown]; Region: COG2323 572264004485 Uncharacterized conserved protein [Function unknown]; Region: COG1434 572264004486 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 572264004487 putative active site [active] 572264004488 Tic20-like protein; Region: Tic20; pfam09685 572264004489 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 572264004490 dimer interface [polypeptide binding]; other site 572264004491 FMN binding site [chemical binding]; other site 572264004492 NADPH bind site [chemical binding]; other site 572264004493 DJ-1 family protein; Region: not_thiJ; TIGR01383 572264004494 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 572264004495 conserved cys residue [active] 572264004496 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 572264004497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264004498 H+ Antiporter protein; Region: 2A0121; TIGR00900 572264004499 putative substrate translocation pore; other site 572264004500 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264004501 dimerization interface [polypeptide binding]; other site 572264004502 putative DNA binding site [nucleotide binding]; other site 572264004503 putative Zn2+ binding site [ion binding]; other site 572264004504 H+ Antiporter protein; Region: 2A0121; TIGR00900 572264004505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264004506 putative substrate translocation pore; other site 572264004507 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 572264004508 active site 572264004509 metal binding site [ion binding]; metal-binding site 572264004510 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572264004511 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 572264004512 bacterial Hfq-like; Region: Hfq; cd01716 572264004513 hexamer interface [polypeptide binding]; other site 572264004514 Sm1 motif; other site 572264004515 RNA binding site [nucleotide binding]; other site 572264004516 Sm2 motif; other site 572264004517 HD domain; Region: HD_3; pfam13023 572264004518 flagellar motor protein MotP; Reviewed; Region: PRK06743 572264004519 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 572264004520 flagellar motor protein MotS; Reviewed; Region: PRK06742 572264004521 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 572264004522 ligand binding site [chemical binding]; other site 572264004523 Response regulator receiver domain; Region: Response_reg; pfam00072 572264004524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264004525 active site 572264004526 phosphorylation site [posttranslational modification] 572264004527 intermolecular recognition site; other site 572264004528 dimerization interface [polypeptide binding]; other site 572264004529 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 572264004530 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 572264004531 putative binding surface; other site 572264004532 active site 572264004533 P2 response regulator binding domain; Region: P2; pfam07194 572264004534 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 572264004535 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264004536 ATP binding site [chemical binding]; other site 572264004537 Mg2+ binding site [ion binding]; other site 572264004538 G-X-G motif; other site 572264004539 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 572264004540 flagellar motor switch protein; Reviewed; Region: PRK06782 572264004541 CheC-like family; Region: CheC; pfam04509 572264004542 CheC-like family; Region: CheC; pfam04509 572264004543 CheC-like family; Region: CheC; pfam04509 572264004544 CheC-like family; Region: CheC; pfam04509 572264004545 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 572264004546 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 572264004547 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 572264004548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264004549 Protein of unknown function (DUF327); Region: DUF327; pfam03885 572264004550 Glutamate-cysteine ligase; Region: GshA; pfam08886 572264004551 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 572264004552 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 572264004553 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 572264004554 flagellar capping protein; Validated; Region: fliD; PRK06798 572264004555 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 572264004556 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 572264004557 Flagellar protein FliS; Region: FliS; cl00654 572264004558 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 572264004559 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 572264004560 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 572264004561 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 572264004562 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 572264004563 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 572264004564 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 572264004565 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 572264004566 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 572264004567 FliG C-terminal domain; Region: FliG_C; pfam01706 572264004568 flagellar assembly protein H; Validated; Region: fliH; PRK06800 572264004569 Flagellar assembly protein FliH; Region: FliH; pfam02108 572264004570 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 572264004571 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 572264004572 Walker A motif; other site 572264004573 ATP binding site [chemical binding]; other site 572264004574 Walker B motif; other site 572264004575 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 572264004576 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 572264004577 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 572264004578 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 572264004579 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 572264004580 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 572264004581 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 572264004582 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 572264004583 Response regulator receiver domain; Region: Response_reg; pfam00072 572264004584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264004585 active site 572264004586 phosphorylation site [posttranslational modification] 572264004587 intermolecular recognition site; other site 572264004588 dimerization interface [polypeptide binding]; other site 572264004589 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 572264004590 flagellin; Provisional; Region: PRK12807 572264004591 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 572264004592 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 572264004593 flagellin; Provisional; Region: PRK12808 572264004594 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 572264004595 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 572264004596 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 572264004597 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 572264004598 N-acetyl-D-glucosamine binding site [chemical binding]; other site 572264004599 catalytic residue [active] 572264004600 flagellar motor switch protein; Validated; Region: PRK06789 572264004601 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 572264004602 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 572264004603 flagellar motor switch protein; Validated; Region: PRK06788 572264004604 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 572264004605 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 572264004606 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 572264004607 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 572264004608 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 572264004609 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 572264004610 FHIPEP family; Region: FHIPEP; pfam00771 572264004611 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889 572264004612 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 572264004613 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 572264004614 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 572264004615 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 572264004616 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 572264004617 Predicted transcriptional regulators [Transcription]; Region: COG1378 572264004618 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 572264004619 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 572264004620 C-terminal domain interface [polypeptide binding]; other site 572264004621 sugar binding site [chemical binding]; other site 572264004622 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 572264004623 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 572264004624 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 572264004625 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264004626 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264004627 Dienelactone hydrolase family; Region: DLH; pfam01738 572264004628 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 572264004629 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 572264004630 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264004631 non-specific DNA binding site [nucleotide binding]; other site 572264004632 salt bridge; other site 572264004633 sequence-specific DNA binding site [nucleotide binding]; other site 572264004634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264004635 H+ Antiporter protein; Region: 2A0121; TIGR00900 572264004636 putative substrate translocation pore; other site 572264004637 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 572264004638 Transcriptional regulator [Transcription]; Region: LysR; COG0583 572264004639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572264004640 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 572264004641 dimerization interface [polypeptide binding]; other site 572264004642 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 572264004643 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264004644 Walker A/P-loop; other site 572264004645 ATP binding site [chemical binding]; other site 572264004646 Q-loop/lid; other site 572264004647 ABC transporter signature motif; other site 572264004648 Walker B; other site 572264004649 D-loop; other site 572264004650 H-loop/switch region; other site 572264004651 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 572264004652 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 572264004653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264004654 dimer interface [polypeptide binding]; other site 572264004655 conserved gate region; other site 572264004656 putative PBP binding loops; other site 572264004657 ABC-ATPase subunit interface; other site 572264004658 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 572264004659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264004660 dimer interface [polypeptide binding]; other site 572264004661 conserved gate region; other site 572264004662 putative PBP binding loops; other site 572264004663 ABC-ATPase subunit interface; other site 572264004664 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 572264004665 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 572264004666 Beta-Casp domain; Region: Beta-Casp; smart01027 572264004667 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 572264004668 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 572264004669 Cupin; Region: Cupin_1; smart00835 572264004670 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 572264004671 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 572264004672 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572264004673 catalytic core [active] 572264004674 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572264004675 hypothetical protein; Provisional; Region: PRK09272 572264004676 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 572264004677 MarR family; Region: MarR_2; pfam12802 572264004678 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 572264004679 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 572264004680 active site 572264004681 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 572264004682 dimer interface [polypeptide binding]; other site 572264004683 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 572264004684 Ligand Binding Site [chemical binding]; other site 572264004685 Molecular Tunnel; other site 572264004686 RNA polymerase factor sigma-70; Validated; Region: PRK06811 572264004687 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264004688 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572264004689 DNA binding residues [nucleotide binding] 572264004690 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 572264004691 VPS10 domain; Region: VPS10; smart00602 572264004692 VPS10 domain; Region: VPS10; smart00602 572264004693 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 572264004694 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 572264004695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572264004696 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 572264004697 DNA-binding site [nucleotide binding]; DNA binding site 572264004698 FCD domain; Region: FCD; pfam07729 572264004699 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 572264004700 EamA-like transporter family; Region: EamA; pfam00892 572264004701 EamA-like transporter family; Region: EamA; pfam00892 572264004702 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 572264004703 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 572264004704 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 572264004705 Predicted permeases [General function prediction only]; Region: COG0701 572264004706 TIGR03943 family protein; Region: TIGR03943 572264004707 Methyltransferase domain; Region: Methyltransf_24; pfam13578 572264004708 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 572264004709 fumarate hydratase; Reviewed; Region: fumC; PRK00485 572264004710 Class II fumarases; Region: Fumarase_classII; cd01362 572264004711 active site 572264004712 tetramer interface [polypeptide binding]; other site 572264004713 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 572264004714 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 572264004715 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 572264004716 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 572264004717 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 572264004718 active site pocket [active] 572264004719 oxyanion hole [active] 572264004720 catalytic triad [active] 572264004721 active site nucleophile [active] 572264004722 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 572264004723 Penicillinase repressor; Region: Pencillinase_R; pfam03965 572264004724 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 572264004725 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 572264004726 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 572264004727 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 572264004728 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 572264004729 catalytic residues [active] 572264004730 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 572264004731 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 572264004732 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264004733 non-specific DNA binding site [nucleotide binding]; other site 572264004734 salt bridge; other site 572264004735 sequence-specific DNA binding site [nucleotide binding]; other site 572264004736 Cupin domain; Region: Cupin_2; pfam07883 572264004737 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 572264004738 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 572264004739 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 572264004740 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 572264004741 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572264004742 catalytic residue [active] 572264004743 Protein of unknown function (DUF445); Region: DUF445; pfam04286 572264004744 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 572264004745 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264004746 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572264004747 DNA binding residues [nucleotide binding] 572264004748 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 572264004749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264004750 active site 572264004751 phosphorylation site [posttranslational modification] 572264004752 intermolecular recognition site; other site 572264004753 dimerization interface [polypeptide binding]; other site 572264004754 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572264004755 DNA binding residues [nucleotide binding] 572264004756 dimerization interface [polypeptide binding]; other site 572264004757 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 572264004758 Histidine kinase; Region: HisKA_3; pfam07730 572264004759 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 572264004760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264004761 Walker A/P-loop; other site 572264004762 ATP binding site [chemical binding]; other site 572264004763 Q-loop/lid; other site 572264004764 ABC transporter signature motif; other site 572264004765 Walker B; other site 572264004766 D-loop; other site 572264004767 H-loop/switch region; other site 572264004768 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 572264004769 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 572264004770 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 572264004771 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 572264004772 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 572264004773 PLD-like domain; Region: PLDc_2; pfam13091 572264004774 putative active site [active] 572264004775 catalytic site [active] 572264004776 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 572264004777 PLD-like domain; Region: PLDc_2; pfam13091 572264004778 putative active site [active] 572264004779 catalytic site [active] 572264004780 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 572264004781 putative nucleotide binding site [chemical binding]; other site 572264004782 uridine monophosphate binding site [chemical binding]; other site 572264004783 homohexameric interface [polypeptide binding]; other site 572264004784 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 572264004785 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 572264004786 aspartate ammonia-lyase; Provisional; Region: PRK14515 572264004787 Aspartase; Region: Aspartase; cd01357 572264004788 active sites [active] 572264004789 tetramer interface [polypeptide binding]; other site 572264004790 malate dehydrogenase; Provisional; Region: PRK13529 572264004791 Malic enzyme, N-terminal domain; Region: malic; pfam00390 572264004792 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 572264004793 NAD(P) binding site [chemical binding]; other site 572264004794 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264004795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264004796 ATP binding site [chemical binding]; other site 572264004797 Mg2+ binding site [ion binding]; other site 572264004798 G-X-G motif; other site 572264004799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264004800 Response regulator receiver domain; Region: Response_reg; pfam00072 572264004801 active site 572264004802 phosphorylation site [posttranslational modification] 572264004803 intermolecular recognition site; other site 572264004804 dimerization interface [polypeptide binding]; other site 572264004805 YcbB domain; Region: YcbB; pfam08664 572264004806 SWIM zinc finger; Region: SWIM; pfam04434 572264004807 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 572264004808 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 572264004809 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572264004810 ATP binding site [chemical binding]; other site 572264004811 putative Mg++ binding site [ion binding]; other site 572264004812 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572264004813 nucleotide binding region [chemical binding]; other site 572264004814 ATP-binding site [chemical binding]; other site 572264004815 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 572264004816 dimer interface [polypeptide binding]; other site 572264004817 active site 572264004818 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 572264004819 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 572264004820 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572264004821 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264004822 non-specific DNA binding site [nucleotide binding]; other site 572264004823 salt bridge; other site 572264004824 sequence-specific DNA binding site [nucleotide binding]; other site 572264004825 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 572264004826 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 572264004827 aspartate kinase; Reviewed; Region: PRK06635 572264004828 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 572264004829 putative nucleotide binding site [chemical binding]; other site 572264004830 putative catalytic residues [active] 572264004831 putative Mg ion binding site [ion binding]; other site 572264004832 putative aspartate binding site [chemical binding]; other site 572264004833 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 572264004834 putative allosteric regulatory site; other site 572264004835 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 572264004836 putative allosteric regulatory residue; other site 572264004837 Lysine riboswitch 572264004838 DoxX-like family; Region: DoxX_3; pfam13781 572264004839 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 572264004840 YndJ-like protein; Region: YndJ; pfam14158 572264004841 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 572264004842 putative active site [active] 572264004843 nucleotide binding site [chemical binding]; other site 572264004844 nudix motif; other site 572264004845 putative metal binding site [ion binding]; other site 572264004846 S-layer homology domain; Region: SLH; pfam00395 572264004847 S-layer homology domain; Region: SLH; pfam00395 572264004848 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 572264004849 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 572264004850 active site 572264004851 metal binding site [ion binding]; metal-binding site 572264004852 S-layer homology domain; Region: SLH; pfam00395 572264004853 S-layer homology domain; Region: SLH; pfam00395 572264004854 S-layer homology domain; Region: SLH; pfam00395 572264004855 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 572264004856 H+ Antiporter protein; Region: 2A0121; TIGR00900 572264004857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264004858 putative substrate translocation pore; other site 572264004859 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 572264004860 Carbon starvation protein CstA; Region: CstA; pfam02554 572264004861 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 572264004862 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 572264004863 Predicted transcriptional regulators [Transcription]; Region: COG1695 572264004864 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 572264004865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264004866 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264004867 putative substrate translocation pore; other site 572264004868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264004869 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264004870 putative substrate translocation pore; other site 572264004871 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 572264004872 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 572264004873 dimer interface [polypeptide binding]; other site 572264004874 active site 572264004875 CoA binding pocket [chemical binding]; other site 572264004876 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 572264004877 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 572264004878 HflX GTPase family; Region: HflX; cd01878 572264004879 G1 box; other site 572264004880 GTP/Mg2+ binding site [chemical binding]; other site 572264004881 Switch I region; other site 572264004882 G2 box; other site 572264004883 G3 box; other site 572264004884 Switch II region; other site 572264004885 G4 box; other site 572264004886 G5 box; other site 572264004887 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 572264004888 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 572264004889 peptide binding site [polypeptide binding]; other site 572264004890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264004891 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264004892 putative substrate translocation pore; other site 572264004893 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 572264004894 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 572264004895 dimer interface [polypeptide binding]; other site 572264004896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264004897 catalytic residue [active] 572264004898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264004899 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572264004900 Coenzyme A binding pocket [chemical binding]; other site 572264004901 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 572264004902 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 572264004903 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 572264004904 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 572264004905 Na2 binding site [ion binding]; other site 572264004906 putative substrate binding site 1 [chemical binding]; other site 572264004907 Na binding site 1 [ion binding]; other site 572264004908 putative substrate binding site 2 [chemical binding]; other site 572264004909 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 572264004910 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 572264004911 NodB motif; other site 572264004912 putative active site [active] 572264004913 putative catalytic site [active] 572264004914 putative Zn binding site [ion binding]; other site 572264004915 Mor transcription activator family; Region: Mor; cl02360 572264004916 Predicted membrane protein [Function unknown]; Region: COG2323 572264004917 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 572264004918 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 572264004919 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 572264004920 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 572264004921 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 572264004922 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 572264004923 methionine sulfoxide reductase A; Provisional; Region: PRK14054 572264004924 short chain dehydrogenase; Provisional; Region: PRK12747 572264004925 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 572264004926 NADP binding site [chemical binding]; other site 572264004927 homodimer interface [polypeptide binding]; other site 572264004928 active site 572264004929 substrate binding site [chemical binding]; other site 572264004930 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 572264004931 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 572264004932 homodimer interface [polypeptide binding]; other site 572264004933 substrate-cofactor binding pocket; other site 572264004934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264004935 catalytic residue [active] 572264004936 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 572264004937 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 572264004938 PYR/PP interface [polypeptide binding]; other site 572264004939 dimer interface [polypeptide binding]; other site 572264004940 TPP binding site [chemical binding]; other site 572264004941 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 572264004942 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 572264004943 TPP-binding site [chemical binding]; other site 572264004944 dimer interface [polypeptide binding]; other site 572264004945 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 572264004946 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 572264004947 putative valine binding site [chemical binding]; other site 572264004948 dimer interface [polypeptide binding]; other site 572264004949 ketol-acid reductoisomerase; Provisional; Region: PRK05479 572264004950 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 572264004951 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 572264004952 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 572264004953 threonine dehydratase; Validated; Region: PRK08639 572264004954 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 572264004955 tetramer interface [polypeptide binding]; other site 572264004956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264004957 catalytic residue [active] 572264004958 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 572264004959 putative Ile/Val binding site [chemical binding]; other site 572264004960 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 572264004961 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 572264004962 putative active site [active] 572264004963 putative metal binding site [ion binding]; other site 572264004964 Protein of unknown function (DUF554); Region: DUF554; pfam04474 572264004965 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264004966 Coenzyme A binding pocket [chemical binding]; other site 572264004967 drug efflux system protein MdtG; Provisional; Region: PRK09874 572264004968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264004969 putative substrate translocation pore; other site 572264004970 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 572264004971 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 572264004972 putative active site [active] 572264004973 metal binding site [ion binding]; metal-binding site 572264004974 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 572264004975 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 572264004976 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 572264004977 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 572264004978 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 572264004979 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 572264004980 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572264004981 Beta-lactamase; Region: Beta-lactamase; pfam00144 572264004982 LytTr DNA-binding domain; Region: LytTR; pfam04397 572264004983 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 572264004984 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 572264004985 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 572264004986 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 572264004987 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 572264004988 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264004989 Coenzyme A binding pocket [chemical binding]; other site 572264004990 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 572264004991 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 572264004992 active site 572264004993 putative substrate binding pocket [chemical binding]; other site 572264004994 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 572264004995 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 572264004996 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 572264004997 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 572264004998 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 572264004999 Int/Topo IB signature motif; other site 572264005000 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572264005001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264005002 non-specific DNA binding site [nucleotide binding]; other site 572264005003 salt bridge; other site 572264005004 sequence-specific DNA binding site [nucleotide binding]; other site 572264005005 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 572264005006 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 572264005007 ORF6C domain; Region: ORF6C; pfam10552 572264005008 Helix-turn-helix domain; Region: HTH_17; pfam12728 572264005009 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 572264005010 hypothetical protein; Validated; Region: PRK08116 572264005011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 572264005012 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 572264005013 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 572264005014 putative metal binding site [ion binding]; other site 572264005015 YopX protein; Region: YopX; pfam09643 572264005016 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 572264005017 Ligand Binding Site [chemical binding]; other site 572264005018 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 572264005019 cofactor binding site; other site 572264005020 DNA binding site [nucleotide binding] 572264005021 substrate interaction site [chemical binding]; other site 572264005022 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 572264005023 Protein of unknown function (DUF3983); Region: DUF3983; pfam13137 572264005024 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 572264005025 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 572264005026 Int/Topo IB signature motif; other site 572264005027 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 572264005028 Phage terminase, small subunit; Region: Terminase_4; cl01525 572264005029 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 572264005030 Phage-related protein [Function unknown]; Region: COG4695; cl01923 572264005031 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 572264005032 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 572264005033 oligomer interface [polypeptide binding]; other site 572264005034 active site residues [active] 572264005035 Phage capsid family; Region: Phage_capsid; pfam05065 572264005036 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 572264005037 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 572264005038 Phage-related minor tail protein [Function unknown]; Region: COG5280 572264005039 membrane protein P6; Region: PHA01399 572264005040 membrane protein P6; Region: PHA01399 572264005041 Phage tail protein; Region: Sipho_tail; pfam05709 572264005042 Phage tail protein; Region: Sipho_tail; cl17486 572264005043 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 572264005044 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 572264005045 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 572264005046 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 572264005047 active site 572264005048 catalytic residues [active] 572264005049 DNA binding site [nucleotide binding] 572264005050 Int/Topo IB signature motif; other site 572264005051 AzlC protein; Region: AzlC; cl00570 572264005052 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 572264005053 active site 572264005054 metal binding site [ion binding]; metal-binding site 572264005055 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 572264005056 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 572264005057 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 572264005058 peptide binding site [polypeptide binding]; other site 572264005059 hypothetical protein; Provisional; Region: PRK06922 572264005060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264005061 S-adenosylmethionine binding site [chemical binding]; other site 572264005062 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 572264005063 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572264005064 FeS/SAM binding site; other site 572264005065 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 572264005066 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572264005067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264005068 Coenzyme A binding pocket [chemical binding]; other site 572264005069 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264005070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264005071 active site 572264005072 phosphorylation site [posttranslational modification] 572264005073 intermolecular recognition site; other site 572264005074 dimerization interface [polypeptide binding]; other site 572264005075 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264005076 DNA binding site [nucleotide binding] 572264005077 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264005078 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264005079 dimerization interface [polypeptide binding]; other site 572264005080 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264005081 dimer interface [polypeptide binding]; other site 572264005082 phosphorylation site [posttranslational modification] 572264005083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264005084 ATP binding site [chemical binding]; other site 572264005085 Mg2+ binding site [ion binding]; other site 572264005086 G-X-G motif; other site 572264005087 Peptidase family M23; Region: Peptidase_M23; pfam01551 572264005088 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 572264005089 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572264005090 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 572264005091 manganese transport protein MntH; Reviewed; Region: PRK00701 572264005092 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 572264005093 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 572264005094 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 572264005095 active site residue [active] 572264005096 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 572264005097 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 572264005098 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 572264005099 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 572264005100 ydaO/yuaA leader 572264005101 Amino acid permease; Region: AA_permease_2; pfam13520 572264005102 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 572264005103 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 572264005104 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 572264005105 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 572264005106 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 572264005107 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572264005108 DNA binding residues [nucleotide binding] 572264005109 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 572264005110 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 572264005111 intersubunit interface [polypeptide binding]; other site 572264005112 active site 572264005113 catalytic residue [active] 572264005114 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 572264005115 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 572264005116 Nucleoside recognition; Region: Gate; pfam07670 572264005117 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 572264005118 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 572264005119 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 572264005120 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 572264005121 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 572264005122 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 572264005123 active site 572264005124 catalytic motif [active] 572264005125 Zn binding site [ion binding]; other site 572264005126 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 572264005127 hypothetical protein; Provisional; Region: PRK01631 572264005128 Family description; Region: DsbD_2; pfam13386 572264005129 VPS10 domain; Region: VPS10; smart00602 572264005130 proline aminopeptidase P II; Provisional; Region: PRK10879 572264005131 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 572264005132 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 572264005133 active site 572264005134 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 572264005135 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 572264005136 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 572264005137 Multicopper oxidase; Region: Cu-oxidase; pfam00394 572264005138 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 572264005139 Bacterial SH3 domain; Region: SH3_3; pfam08239 572264005140 Bacterial SH3 domain; Region: SH3_3; pfam08239 572264005141 Bacterial SH3 domain; Region: SH3_3; pfam08239 572264005142 Bacterial SH3 domain; Region: SH3_3; pfam08239 572264005143 Bacterial SH3 domain; Region: SH3_3; pfam08239 572264005144 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 572264005145 Peptidase family M23; Region: Peptidase_M23; pfam01551 572264005146 DNA topoisomerase III; Provisional; Region: PRK07726 572264005147 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 572264005148 active site 572264005149 putative interdomain interaction site [polypeptide binding]; other site 572264005150 putative metal-binding site [ion binding]; other site 572264005151 putative nucleotide binding site [chemical binding]; other site 572264005152 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 572264005153 domain I; other site 572264005154 DNA binding groove [nucleotide binding] 572264005155 phosphate binding site [ion binding]; other site 572264005156 domain II; other site 572264005157 domain III; other site 572264005158 nucleotide binding site [chemical binding]; other site 572264005159 catalytic site [active] 572264005160 domain IV; other site 572264005161 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 572264005162 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 572264005163 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 572264005164 Sodium Bile acid symporter family; Region: SBF; cl17470 572264005165 azoreductase; Provisional; Region: PRK13555 572264005166 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 572264005167 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572264005168 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 572264005169 dimer interface [polypeptide binding]; other site 572264005170 substrate binding site [chemical binding]; other site 572264005171 metal binding site [ion binding]; metal-binding site 572264005172 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 572264005173 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 572264005174 YtkA-like; Region: YtkA; pfam13115 572264005175 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 572264005176 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 572264005177 EamA-like transporter family; Region: EamA; pfam00892 572264005178 EamA-like transporter family; Region: EamA; pfam00892 572264005179 Transcriptional regulator [Transcription]; Region: LysR; COG0583 572264005180 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572264005181 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 572264005182 dimerization interface [polypeptide binding]; other site 572264005183 Predicted transcriptional regulator [Transcription]; Region: COG1959 572264005184 Transcriptional regulator; Region: Rrf2; pfam02082 572264005185 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 572264005186 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 572264005187 catalytic residues [active] 572264005188 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 572264005189 dimer interface [polypeptide binding]; other site 572264005190 FMN binding site [chemical binding]; other site 572264005191 amidase; Provisional; Region: PRK06707 572264005192 Amidase; Region: Amidase; cl11426 572264005193 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 572264005194 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 572264005195 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 572264005196 tetramer (dimer of dimers) interface [polypeptide binding]; other site 572264005197 NAD binding site [chemical binding]; other site 572264005198 dimer interface [polypeptide binding]; other site 572264005199 substrate binding site [chemical binding]; other site 572264005200 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 572264005201 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572264005202 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 572264005203 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 572264005204 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 572264005205 S-layer homology domain; Region: SLH; pfam00395 572264005206 S-layer homology domain; Region: SLH; pfam00395 572264005207 S-layer homology domain; Region: SLH; pfam00395 572264005208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264005209 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264005210 acyl-CoA synthetase; Validated; Region: PRK06839 572264005211 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572264005212 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 572264005213 acyl-activating enzyme (AAE) consensus motif; other site 572264005214 putative AMP binding site [chemical binding]; other site 572264005215 putative active site [active] 572264005216 putative CoA binding site [chemical binding]; other site 572264005217 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 572264005218 dimer interaction site [polypeptide binding]; other site 572264005219 substrate-binding tunnel; other site 572264005220 active site 572264005221 catalytic site [active] 572264005222 substrate binding site [chemical binding]; other site 572264005223 hypothetical protein; Validated; Region: PRK06840 572264005224 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 572264005225 active site 572264005226 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 572264005227 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 572264005228 putative ligand binding site [chemical binding]; other site 572264005229 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 572264005230 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 572264005231 Walker A/P-loop; other site 572264005232 ATP binding site [chemical binding]; other site 572264005233 Q-loop/lid; other site 572264005234 ABC transporter signature motif; other site 572264005235 Walker B; other site 572264005236 D-loop; other site 572264005237 H-loop/switch region; other site 572264005238 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 572264005239 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 572264005240 Walker A/P-loop; other site 572264005241 ATP binding site [chemical binding]; other site 572264005242 Q-loop/lid; other site 572264005243 ABC transporter signature motif; other site 572264005244 Walker B; other site 572264005245 D-loop; other site 572264005246 H-loop/switch region; other site 572264005247 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 572264005248 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 572264005249 TM-ABC transporter signature motif; other site 572264005250 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 572264005251 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 572264005252 TM-ABC transporter signature motif; other site 572264005253 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572264005254 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 572264005255 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 572264005256 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 572264005257 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 572264005258 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264005259 putative Zn2+ binding site [ion binding]; other site 572264005260 putative DNA binding site [nucleotide binding]; other site 572264005261 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 572264005262 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 572264005263 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 572264005264 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 572264005265 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 572264005266 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 572264005267 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 572264005268 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 572264005269 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 572264005270 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 572264005271 Walker A/P-loop; other site 572264005272 ATP binding site [chemical binding]; other site 572264005273 Q-loop/lid; other site 572264005274 ABC transporter signature motif; other site 572264005275 Walker B; other site 572264005276 D-loop; other site 572264005277 H-loop/switch region; other site 572264005278 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 572264005279 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 572264005280 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 572264005281 Walker A/P-loop; other site 572264005282 ATP binding site [chemical binding]; other site 572264005283 Q-loop/lid; other site 572264005284 ABC transporter signature motif; other site 572264005285 Walker B; other site 572264005286 D-loop; other site 572264005287 H-loop/switch region; other site 572264005288 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 572264005289 putative dimer interface [polypeptide binding]; other site 572264005290 catalytic triad [active] 572264005291 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 572264005292 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 572264005293 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 572264005294 dimer interface [polypeptide binding]; other site 572264005295 FMN binding site [chemical binding]; other site 572264005296 Bacterial SH3 domain; Region: SH3_3; pfam08239 572264005297 Bacterial SH3 domain; Region: SH3_3; pfam08239 572264005298 Bacterial SH3 domain; Region: SH3_3; pfam08239 572264005299 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 572264005300 NlpC/P60 family; Region: NLPC_P60; pfam00877 572264005301 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 572264005302 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 572264005303 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 572264005304 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264005305 Walker A/P-loop; other site 572264005306 ATP binding site [chemical binding]; other site 572264005307 Q-loop/lid; other site 572264005308 ABC transporter signature motif; other site 572264005309 Walker B; other site 572264005310 D-loop; other site 572264005311 H-loop/switch region; other site 572264005312 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264005313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264005314 active site 572264005315 phosphorylation site [posttranslational modification] 572264005316 intermolecular recognition site; other site 572264005317 dimerization interface [polypeptide binding]; other site 572264005318 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264005319 DNA binding site [nucleotide binding] 572264005320 Protein of unknown function (DUF475); Region: DUF475; cl17481 572264005321 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264005322 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264005323 dimerization interface [polypeptide binding]; other site 572264005324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264005325 dimer interface [polypeptide binding]; other site 572264005326 phosphorylation site [posttranslational modification] 572264005327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264005328 ATP binding site [chemical binding]; other site 572264005329 Mg2+ binding site [ion binding]; other site 572264005330 G-X-G motif; other site 572264005331 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 572264005332 classical (c) SDRs; Region: SDR_c; cd05233 572264005333 NAD(P) binding site [chemical binding]; other site 572264005334 active site 572264005335 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 572264005336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264005337 S-adenosylmethionine binding site [chemical binding]; other site 572264005338 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 572264005339 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 572264005340 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 572264005341 NodB motif; other site 572264005342 active site 572264005343 catalytic site [active] 572264005344 metal binding site [ion binding]; metal-binding site 572264005345 SdpI/YhfL protein family; Region: SdpI; pfam13630 572264005346 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 572264005347 nudix motif; other site 572264005348 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 572264005349 homoserine dehydrogenase; Provisional; Region: PRK06349 572264005350 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 572264005351 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 572264005352 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 572264005353 threonine synthase; Reviewed; Region: PRK06721 572264005354 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 572264005355 homodimer interface [polypeptide binding]; other site 572264005356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264005357 catalytic residue [active] 572264005358 homoserine kinase; Provisional; Region: PRK01212 572264005359 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 572264005360 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 572264005361 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 572264005362 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 572264005363 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264005364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264005365 active site 572264005366 phosphorylation site [posttranslational modification] 572264005367 intermolecular recognition site; other site 572264005368 dimerization interface [polypeptide binding]; other site 572264005369 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264005370 DNA binding site [nucleotide binding] 572264005371 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264005372 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264005373 dimerization interface [polypeptide binding]; other site 572264005374 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264005375 dimer interface [polypeptide binding]; other site 572264005376 phosphorylation site [posttranslational modification] 572264005377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264005378 ATP binding site [chemical binding]; other site 572264005379 Mg2+ binding site [ion binding]; other site 572264005380 G-X-G motif; other site 572264005381 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 572264005382 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 572264005383 NodB motif; other site 572264005384 active site 572264005385 catalytic site [active] 572264005386 Zn binding site [ion binding]; other site 572264005387 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 572264005388 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 572264005389 MgtC family; Region: MgtC; pfam02308 572264005390 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 572264005391 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264005392 Coenzyme A binding pocket [chemical binding]; other site 572264005393 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 572264005394 IucA / IucC family; Region: IucA_IucC; pfam04183 572264005395 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 572264005396 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 572264005397 IucA / IucC family; Region: IucA_IucC; pfam04183 572264005398 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 572264005399 acyl-CoA synthetase; Validated; Region: PRK08308 572264005400 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572264005401 acyl-activating enzyme (AAE) consensus motif; other site 572264005402 AMP binding site [chemical binding]; other site 572264005403 active site 572264005404 CoA binding site [chemical binding]; other site 572264005405 acyl carrier protein; Provisional; Region: PRK07639 572264005406 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 572264005407 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 572264005408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264005409 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264005410 putative substrate translocation pore; other site 572264005411 Lysine efflux permease [General function prediction only]; Region: COG1279 572264005412 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 572264005413 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572264005414 DNA-binding site [nucleotide binding]; DNA binding site 572264005415 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572264005416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264005417 homodimer interface [polypeptide binding]; other site 572264005418 catalytic residue [active] 572264005419 Protein of unknown function (DUF3933); Region: DUF3933; pfam13069 572264005420 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 572264005421 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 572264005422 active site 572264005423 nucleophile elbow; other site 572264005424 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 572264005425 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 572264005426 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 572264005427 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 572264005428 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 572264005429 nudix motif; other site 572264005430 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 572264005431 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 572264005432 homodimer interface [polypeptide binding]; other site 572264005433 NAD binding pocket [chemical binding]; other site 572264005434 ATP binding pocket [chemical binding]; other site 572264005435 Mg binding site [ion binding]; other site 572264005436 active-site loop [active] 572264005437 SIR2-like domain; Region: SIR2_2; pfam13289 572264005438 Divergent AAA domain; Region: AAA_4; pfam04326 572264005439 Phage terminase, small subunit; Region: Terminase_4; pfam05119 572264005440 Phage-related protein [Function unknown]; Region: COG4695; cl01923 572264005441 Phage portal protein; Region: Phage_portal; pfam04860 572264005442 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 572264005443 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 572264005444 Phage capsid family; Region: Phage_capsid; pfam05065 572264005445 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 572264005446 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 572264005447 catalytic residues [active] 572264005448 catalytic nucleophile [active] 572264005449 Recombinase; Region: Recombinase; pfam07508 572264005450 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 572264005451 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 572264005452 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 572264005453 FtsX-like permease family; Region: FtsX; pfam02687 572264005454 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 572264005455 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 572264005456 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 572264005457 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 572264005458 active site 572264005459 catalytic residues [active] 572264005460 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264005461 dimerization interface [polypeptide binding]; other site 572264005462 putative DNA binding site [nucleotide binding]; other site 572264005463 putative Zn2+ binding site [ion binding]; other site 572264005464 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 572264005465 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 572264005466 active site 572264005467 catalytic tetrad [active] 572264005468 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 572264005469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264005470 putative substrate translocation pore; other site 572264005471 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 572264005472 Protein of unknown function (DUF664); Region: DUF664; pfam04978 572264005473 DinB superfamily; Region: DinB_2; pfam12867 572264005474 GTPase RsgA; Reviewed; Region: PRK01889 572264005475 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 572264005476 RNA binding site [nucleotide binding]; other site 572264005477 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 572264005478 GTPase/Zn-binding domain interface [polypeptide binding]; other site 572264005479 GTP/Mg2+ binding site [chemical binding]; other site 572264005480 G4 box; other site 572264005481 G5 box; other site 572264005482 G1 box; other site 572264005483 Switch I region; other site 572264005484 G2 box; other site 572264005485 G3 box; other site 572264005486 Switch II region; other site 572264005487 Tar ligand binding domain homologue; Region: TarH; pfam02203 572264005488 Cache domain; Region: Cache_1; pfam02743 572264005489 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 572264005490 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264005491 dimerization interface [polypeptide binding]; other site 572264005492 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572264005493 dimer interface [polypeptide binding]; other site 572264005494 putative CheW interface [polypeptide binding]; other site 572264005495 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 572264005496 Uncharacterized membrane protein [Function unknown]; Region: COG3949 572264005497 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 572264005498 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 572264005499 dimerization interface [polypeptide binding]; other site 572264005500 DPS ferroxidase diiron center [ion binding]; other site 572264005501 ion pore; other site 572264005502 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 572264005503 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 572264005504 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 572264005505 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 572264005506 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 572264005507 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 572264005508 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572264005509 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572264005510 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 572264005511 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 572264005512 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 572264005513 active site 572264005514 catalytic tetrad [active] 572264005515 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 572264005516 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 572264005517 P-loop, Walker A motif; other site 572264005518 Base recognition motif; other site 572264005519 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 572264005520 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 572264005521 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264005522 Coenzyme A binding pocket [chemical binding]; other site 572264005523 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 572264005524 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 572264005525 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 572264005526 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 572264005527 metal binding site [ion binding]; metal-binding site 572264005528 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 572264005529 NADH(P)-binding; Region: NAD_binding_10; pfam13460 572264005530 NAD binding site [chemical binding]; other site 572264005531 active site 572264005532 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 572264005533 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 572264005534 active site 572264005535 FMN binding site [chemical binding]; other site 572264005536 substrate binding site [chemical binding]; other site 572264005537 homotetramer interface [polypeptide binding]; other site 572264005538 catalytic residue [active] 572264005539 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 572264005540 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 572264005541 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 572264005542 DNA binding site [nucleotide binding] 572264005543 active site 572264005544 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 572264005545 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 572264005546 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 572264005547 peptide binding site [polypeptide binding]; other site 572264005548 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 572264005549 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 572264005550 active site 572264005551 metal binding site [ion binding]; metal-binding site 572264005552 short chain dehydrogenase; Provisional; Region: PRK08309 572264005553 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572264005554 catalytic core [active] 572264005555 CotH protein; Region: CotH; pfam08757 572264005556 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 572264005557 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 572264005558 nudix motif; other site 572264005559 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 572264005560 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 572264005561 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 572264005562 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 572264005563 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 572264005564 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 572264005565 Cl binding site [ion binding]; other site 572264005566 oligomer interface [polypeptide binding]; other site 572264005567 Predicted permeases [General function prediction only]; Region: COG0701 572264005568 Predicted membrane protein [Function unknown]; Region: COG3689 572264005569 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 572264005570 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 572264005571 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 572264005572 putative active site [active] 572264005573 catalytic site [active] 572264005574 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 572264005575 putative active site [active] 572264005576 catalytic site [active] 572264005577 Coat F domain; Region: Coat_F; pfam07875 572264005578 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 572264005579 NADH(P)-binding; Region: NAD_binding_10; pfam13460 572264005580 NAD binding site [chemical binding]; other site 572264005581 substrate binding site [chemical binding]; other site 572264005582 putative active site [active] 572264005583 Protein of unknown function (DUF456); Region: DUF456; pfam04306 572264005584 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 572264005585 Domain of unknown function DUF21; Region: DUF21; pfam01595 572264005586 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 572264005587 Transporter associated domain; Region: CorC_HlyC; smart01091 572264005588 FOG: CBS domain [General function prediction only]; Region: COG0517 572264005589 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 572264005590 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 572264005591 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 572264005592 dimer interface [polypeptide binding]; other site 572264005593 putative tRNA-binding site [nucleotide binding]; other site 572264005594 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 572264005595 DinB superfamily; Region: DinB_2; pfam12867 572264005596 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 572264005597 stage II sporulation protein P; Region: spore_II_P; TIGR02867 572264005598 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572264005599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264005600 Coenzyme A binding pocket [chemical binding]; other site 572264005601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 572264005602 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 572264005603 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 572264005604 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+ for their activity and contain a highly...; Region: Nudix_Hydrolase_6; cd04663 572264005605 nudix motif; other site 572264005606 amidase; Provisional; Region: PRK06828 572264005607 Amidase; Region: Amidase; pfam01425 572264005608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264005609 putative substrate translocation pore; other site 572264005610 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 572264005611 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 572264005612 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 572264005613 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 572264005614 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 572264005615 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 572264005616 Transcriptional regulator [Transcription]; Region: IclR; COG1414 572264005617 Bacterial transcriptional regulator; Region: IclR; pfam01614 572264005618 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 572264005619 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 572264005620 active site 572264005621 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 572264005622 Amidohydrolase; Region: Amidohydro_2; pfam04909 572264005623 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 572264005624 homotrimer interaction site [polypeptide binding]; other site 572264005625 putative active site [active] 572264005626 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 572264005627 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 572264005628 NAD binding site [chemical binding]; other site 572264005629 catalytic residues [active] 572264005630 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 572264005631 acetaldehyde dehydrogenase; Validated; Region: PRK08300 572264005632 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 572264005633 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 572264005634 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 572264005635 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 572264005636 active site 572264005637 catalytic residues [active] 572264005638 metal binding site [ion binding]; metal-binding site 572264005639 DmpG-like communication domain; Region: DmpG_comm; pfam07836 572264005640 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 572264005641 4-oxalocrotonate tautomerase; Provisional; Region: PRK01964 572264005642 active site 1 [active] 572264005643 dimer interface [polypeptide binding]; other site 572264005644 hexamer interface [polypeptide binding]; other site 572264005645 active site 2 [active] 572264005646 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572264005647 catalytic core [active] 572264005648 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264005649 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 572264005650 active site 572264005651 motif I; other site 572264005652 motif II; other site 572264005653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264005654 DinB superfamily; Region: DinB_2; pfam12867 572264005655 DinB family; Region: DinB; cl17821 572264005656 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 572264005657 alanine racemase; Reviewed; Region: alr; PRK00053 572264005658 active site 572264005659 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 572264005660 dimer interface [polypeptide binding]; other site 572264005661 substrate binding site [chemical binding]; other site 572264005662 catalytic residues [active] 572264005663 Methyltransferase domain; Region: Methyltransf_31; pfam13847 572264005664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264005665 S-adenosylmethionine binding site [chemical binding]; other site 572264005666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264005667 Coenzyme A binding pocket [chemical binding]; other site 572264005668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264005669 Coenzyme A binding pocket [chemical binding]; other site 572264005670 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 572264005671 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 572264005672 glycosyltransferase, MGT family; Region: MGT; TIGR01426 572264005673 active site 572264005674 TDP-binding site; other site 572264005675 acceptor substrate-binding pocket; other site 572264005676 homodimer interface [polypeptide binding]; other site 572264005677 Uncharacterized conserved protein [Function unknown]; Region: COG1284 572264005678 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 572264005679 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 572264005680 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 572264005681 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572264005682 DNA-binding site [nucleotide binding]; DNA binding site 572264005683 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572264005684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264005685 homodimer interface [polypeptide binding]; other site 572264005686 catalytic residue [active] 572264005687 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264005688 Coenzyme A binding pocket [chemical binding]; other site 572264005689 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 572264005690 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 572264005691 active site 572264005692 metal binding site [ion binding]; metal-binding site 572264005693 Src Homology 3 domain superfamily; Region: SH3; cl17036 572264005694 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 572264005695 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 572264005696 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264005697 Coenzyme A binding pocket [chemical binding]; other site 572264005698 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 572264005699 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 572264005700 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 572264005701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264005702 Coenzyme A binding pocket [chemical binding]; other site 572264005703 Cupin domain; Region: Cupin_2; cl17218 572264005704 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 572264005705 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 572264005706 Methyltransferase domain; Region: Methyltransf_31; pfam13847 572264005707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264005708 S-adenosylmethionine binding site [chemical binding]; other site 572264005709 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 572264005710 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 572264005711 Potassium binding sites [ion binding]; other site 572264005712 Cesium cation binding sites [ion binding]; other site 572264005713 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 572264005714 DEAD-like helicases superfamily; Region: DEXDc; smart00487 572264005715 ATP binding site [chemical binding]; other site 572264005716 putative Mg++ binding site [ion binding]; other site 572264005717 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572264005718 nucleotide binding region [chemical binding]; other site 572264005719 ATP-binding site [chemical binding]; other site 572264005720 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 572264005721 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572264005722 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 572264005723 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 572264005724 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 572264005725 NADP binding site [chemical binding]; other site 572264005726 dimer interface [polypeptide binding]; other site 572264005727 RNA polymerase sigma factor; Provisional; Region: PRK12543 572264005728 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264005729 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572264005730 DNA binding residues [nucleotide binding] 572264005731 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 572264005732 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 572264005733 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572264005734 Protein of unknown function (DUF3925); Region: DUF3925; pfam13063 572264005735 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 572264005736 catalytic residues [active] 572264005737 dimer interface [polypeptide binding]; other site 572264005738 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 572264005739 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 572264005740 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 572264005741 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 572264005742 Protein of unknown function DUF58; Region: DUF58; pfam01882 572264005743 MoxR-like ATPases [General function prediction only]; Region: COG0714 572264005744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264005745 Walker A motif; other site 572264005746 ATP binding site [chemical binding]; other site 572264005747 Walker B motif; other site 572264005748 arginine finger; other site 572264005749 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 572264005750 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 572264005751 [4Fe-4S] binding site [ion binding]; other site 572264005752 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 572264005753 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 572264005754 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 572264005755 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 572264005756 molybdopterin cofactor binding site; other site 572264005757 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 572264005758 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 572264005759 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 572264005760 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 572264005761 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 572264005762 ligand binding site [chemical binding]; other site 572264005763 flexible hinge region; other site 572264005764 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 572264005765 putative switch regulator; other site 572264005766 non-specific DNA interactions [nucleotide binding]; other site 572264005767 DNA binding site [nucleotide binding] 572264005768 sequence specific DNA binding site [nucleotide binding]; other site 572264005769 putative cAMP binding site [chemical binding]; other site 572264005770 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 572264005771 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572264005772 FeS/SAM binding site; other site 572264005773 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 572264005774 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 572264005775 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 572264005776 ATP binding site [chemical binding]; other site 572264005777 substrate interface [chemical binding]; other site 572264005778 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 572264005779 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 572264005780 dimer interface [polypeptide binding]; other site 572264005781 putative functional site; other site 572264005782 putative MPT binding site; other site 572264005783 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 572264005784 MoaE homodimer interface [polypeptide binding]; other site 572264005785 MoaD interaction [polypeptide binding]; other site 572264005786 active site residues [active] 572264005787 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 572264005788 MoaE interaction surface [polypeptide binding]; other site 572264005789 MoeB interaction surface [polypeptide binding]; other site 572264005790 thiocarboxylated glycine; other site 572264005791 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 572264005792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264005793 putative substrate translocation pore; other site 572264005794 Predicted permeases [General function prediction only]; Region: COG0679 572264005795 precorrin-2 dehydrogenase; Validated; Region: PRK06719 572264005796 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 572264005797 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 572264005798 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 572264005799 putative active site [active] 572264005800 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 572264005801 putative active site [active] 572264005802 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 572264005803 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 572264005804 active site 572264005805 SAM binding site [chemical binding]; other site 572264005806 homodimer interface [polypeptide binding]; other site 572264005807 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 572264005808 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 572264005809 [2Fe-2S] cluster binding site [ion binding]; other site 572264005810 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 572264005811 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572264005812 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572264005813 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 572264005814 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 572264005815 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 572264005816 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 572264005817 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 572264005818 Hemerythrin-like domain; Region: Hr-like; cd12108 572264005819 Excalibur calcium-binding domain; Region: Excalibur; smart00894 572264005820 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 572264005821 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 572264005822 PGAP1-like protein; Region: PGAP1; pfam07819 572264005823 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 572264005824 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 572264005825 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 572264005826 nucleophilic elbow; other site 572264005827 catalytic triad; other site 572264005828 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 572264005829 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572264005830 Zn2+ binding site [ion binding]; other site 572264005831 Mg2+ binding site [ion binding]; other site 572264005832 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 572264005833 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264005834 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264005835 ABC transporter; Region: ABC_tran_2; pfam12848 572264005836 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264005837 Bax inhibitor 1 like; Region: BaxI_1; cl17691 572264005838 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 572264005839 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 572264005840 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 572264005841 dimer interface [polypeptide binding]; other site 572264005842 ssDNA binding site [nucleotide binding]; other site 572264005843 tetramer (dimer of dimers) interface [polypeptide binding]; other site 572264005844 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264005845 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264005846 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 572264005847 Virulence factor; Region: Virulence_fact; pfam13769 572264005848 HEAT repeats; Region: HEAT_2; pfam13646 572264005849 HEAT repeats; Region: HEAT_2; pfam13646 572264005850 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 572264005851 Protein of unknown function, DUF393; Region: DUF393; pfam04134 572264005852 Disulphide isomerase; Region: Disulph_isomer; pfam06491 572264005853 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 572264005854 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 572264005855 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 572264005856 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 572264005857 active site 572264005858 HIGH motif; other site 572264005859 KMSK motif region; other site 572264005860 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 572264005861 tRNA binding surface [nucleotide binding]; other site 572264005862 anticodon binding site; other site 572264005863 Methyltransferase domain; Region: Methyltransf_32; pfam13679 572264005864 Methyltransferase domain; Region: Methyltransf_31; pfam13847 572264005865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264005866 S-adenosylmethionine binding site [chemical binding]; other site 572264005867 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 572264005868 putative catalytic site [active] 572264005869 putative metal binding site [ion binding]; other site 572264005870 putative phosphate binding site [ion binding]; other site 572264005871 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264005872 binding surface 572264005873 TPR motif; other site 572264005874 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 572264005875 putative active site [active] 572264005876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264005877 binding surface 572264005878 TPR motif; other site 572264005879 TPR repeat; Region: TPR_11; pfam13414 572264005880 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264005881 binding surface 572264005882 TPR motif; other site 572264005883 Tetratricopeptide repeat; Region: TPR_16; pfam13432 572264005884 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264005885 binding surface 572264005886 TPR motif; other site 572264005887 TPR repeat; Region: TPR_11; pfam13414 572264005888 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264005889 binding surface 572264005890 TPR motif; other site 572264005891 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264005892 binding surface 572264005893 Tetratricopeptide repeat; Region: TPR_12; pfam13424 572264005894 TPR motif; other site 572264005895 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264005896 binding surface 572264005897 TPR motif; other site 572264005898 Tetratricopeptide repeat; Region: TPR_12; pfam13424 572264005899 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264005900 binding surface 572264005901 TPR motif; other site 572264005902 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 572264005903 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 572264005904 HIGH motif; other site 572264005905 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 572264005906 active site 572264005907 KMSKS motif; other site 572264005908 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 572264005909 tRNA binding surface [nucleotide binding]; other site 572264005910 anticodon binding site; other site 572264005911 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 572264005912 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 572264005913 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 572264005914 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 572264005915 Zn binding site [ion binding]; other site 572264005916 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 572264005917 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 572264005918 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 572264005919 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 572264005920 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 572264005921 Dimer interface [polypeptide binding]; other site 572264005922 anticodon binding site; other site 572264005923 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 572264005924 homodimer interface [polypeptide binding]; other site 572264005925 motif 1; other site 572264005926 motif 2; other site 572264005927 active site 572264005928 motif 3; other site 572264005929 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 572264005930 metal ion-dependent adhesion site (MIDAS); other site 572264005931 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 572264005932 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 572264005933 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264005934 Walker A motif; other site 572264005935 ATP binding site [chemical binding]; other site 572264005936 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 572264005937 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 572264005938 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 572264005939 active site 572264005940 ATP binding site [chemical binding]; other site 572264005941 substrate binding site [chemical binding]; other site 572264005942 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264005943 binding surface 572264005944 TPR motif; other site 572264005945 TPR repeat; Region: TPR_11; pfam13414 572264005946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264005947 binding surface 572264005948 TPR motif; other site 572264005949 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264005950 binding surface 572264005951 Tetratricopeptide repeat; Region: TPR_12; pfam13424 572264005952 TPR motif; other site 572264005953 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 572264005954 SseB protein; Region: SseB; cl06279 572264005955 Proteins of 100 residues with WXG; Region: WXG100; cl02005 572264005956 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 572264005957 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 572264005958 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 572264005959 catalytic residues [active] 572264005960 catalytic nucleophile [active] 572264005961 Recombinase; Region: Recombinase; pfam07508 572264005962 Transposase; Region: DEDD_Tnp_IS110; pfam01548 572264005963 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 572264005964 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 572264005965 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 572264005966 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 572264005967 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 572264005968 catalytic residues [active] 572264005969 catalytic nucleophile [active] 572264005970 Recombinase; Region: Recombinase; pfam07508 572264005971 Transposase; Region: DEDD_Tnp_IS110; pfam01548 572264005972 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 572264005973 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 572264005974 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 572264005975 glycerate kinase; Region: TIGR00045 572264005976 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 572264005977 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 572264005978 transmembrane helices; other site 572264005979 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264005980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264005981 active site 572264005982 phosphorylation site [posttranslational modification] 572264005983 intermolecular recognition site; other site 572264005984 dimerization interface [polypeptide binding]; other site 572264005985 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264005986 DNA binding site [nucleotide binding] 572264005987 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264005988 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264005989 dimerization interface [polypeptide binding]; other site 572264005990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264005991 dimer interface [polypeptide binding]; other site 572264005992 phosphorylation site [posttranslational modification] 572264005993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264005994 ATP binding site [chemical binding]; other site 572264005995 Mg2+ binding site [ion binding]; other site 572264005996 G-X-G motif; other site 572264005997 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 572264005998 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 572264005999 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 572264006000 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 572264006001 Na2 binding site [ion binding]; other site 572264006002 putative substrate binding site 1 [chemical binding]; other site 572264006003 Na binding site 1 [ion binding]; other site 572264006004 putative substrate binding site 2 [chemical binding]; other site 572264006005 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572264006006 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 572264006007 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 572264006008 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 572264006009 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264006010 motif II; other site 572264006011 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 572264006012 fructuronate transporter; Provisional; Region: PRK10034; cl15264 572264006013 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 572264006014 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 572264006015 active site 572264006016 NAD binding site [chemical binding]; other site 572264006017 metal binding site [ion binding]; metal-binding site 572264006018 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 572264006019 aspartate racemase; Region: asp_race; TIGR00035 572264006020 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 572264006021 homodimer interaction site [polypeptide binding]; other site 572264006022 cofactor binding site; other site 572264006023 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 572264006024 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264006025 Coenzyme A binding pocket [chemical binding]; other site 572264006026 hypothetical protein; Validated; Region: PRK06769 572264006027 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264006028 active site 572264006029 motif I; other site 572264006030 motif II; other site 572264006031 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 572264006032 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264006033 Coenzyme A binding pocket [chemical binding]; other site 572264006034 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 572264006035 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 572264006036 Walker A/P-loop; other site 572264006037 ATP binding site [chemical binding]; other site 572264006038 Q-loop/lid; other site 572264006039 ABC transporter signature motif; other site 572264006040 Walker B; other site 572264006041 D-loop; other site 572264006042 H-loop/switch region; other site 572264006043 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 572264006044 YpjP-like protein; Region: YpjP; pfam14005 572264006045 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 572264006046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264006047 motif II; other site 572264006048 hypothetical protein; Provisional; Region: PRK06724 572264006049 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572264006050 active site 572264006051 metal binding site [ion binding]; metal-binding site 572264006052 Phosphotransferase enzyme family; Region: APH; pfam01636 572264006053 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 572264006054 active site 572264006055 ATP binding site [chemical binding]; other site 572264006056 substrate binding site [chemical binding]; other site 572264006057 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 572264006058 Active site serine [active] 572264006059 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572264006060 Beta-lactamase; Region: Beta-lactamase; pfam00144 572264006061 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 572264006062 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 572264006063 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 572264006064 thymidylate synthase; Region: thym_sym; TIGR03284 572264006065 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 572264006066 dimerization interface [polypeptide binding]; other site 572264006067 active site 572264006068 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 572264006069 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 572264006070 folate binding site [chemical binding]; other site 572264006071 NADP+ binding site [chemical binding]; other site 572264006072 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 572264006073 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 572264006074 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 572264006075 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572264006076 azoreductase; Reviewed; Region: PRK00170 572264006077 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 572264006078 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 572264006079 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 572264006080 putative acyl-acceptor binding pocket; other site 572264006081 Haemolysin-III related; Region: HlyIII; cl03831 572264006082 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 572264006083 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 572264006084 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 572264006085 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 572264006086 EDD domain protein, DegV family; Region: DegV; TIGR00762 572264006087 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 572264006088 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 572264006089 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 572264006090 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 572264006091 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 572264006092 Cu(I) binding site [ion binding]; other site 572264006093 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 572264006094 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 572264006095 putative dimer interface [polypeptide binding]; other site 572264006096 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 572264006097 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 572264006098 active site 572264006099 dimer interface [polypeptide binding]; other site 572264006100 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 572264006101 Ligand Binding Site [chemical binding]; other site 572264006102 Molecular Tunnel; other site 572264006103 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 572264006104 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 572264006105 active site 572264006106 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 572264006107 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 572264006108 siderophore binding site; other site 572264006109 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 572264006110 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 572264006111 homodimer interface [polypeptide binding]; other site 572264006112 substrate-cofactor binding pocket; other site 572264006113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264006114 catalytic residue [active] 572264006115 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 572264006116 FMN binding site [chemical binding]; other site 572264006117 dimer interface [polypeptide binding]; other site 572264006118 Isochorismatase family; Region: Isochorismatase; pfam00857 572264006119 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 572264006120 catalytic triad [active] 572264006121 conserved cis-peptide bond; other site 572264006122 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 572264006123 nudix motif; other site 572264006124 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 572264006125 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 572264006126 putative dimer interface [polypeptide binding]; other site 572264006127 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 572264006128 Mechanosensitive ion channel; Region: MS_channel; pfam00924 572264006129 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 572264006130 GAF domain; Region: GAF; pfam01590 572264006131 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 572264006132 Histidine kinase; Region: HisKA_3; pfam07730 572264006133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264006134 ATP binding site [chemical binding]; other site 572264006135 Mg2+ binding site [ion binding]; other site 572264006136 G-X-G motif; other site 572264006137 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 572264006138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264006139 active site 572264006140 phosphorylation site [posttranslational modification] 572264006141 intermolecular recognition site; other site 572264006142 dimerization interface [polypeptide binding]; other site 572264006143 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572264006144 DNA binding residues [nucleotide binding] 572264006145 dimerization interface [polypeptide binding]; other site 572264006146 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 572264006147 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 572264006148 putative active site [active] 572264006149 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 572264006150 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 572264006151 NAD binding site [chemical binding]; other site 572264006152 substrate binding site [chemical binding]; other site 572264006153 catalytic Zn binding site [ion binding]; other site 572264006154 tetramer interface [polypeptide binding]; other site 572264006155 structural Zn binding site [ion binding]; other site 572264006156 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 572264006157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264006158 dimer interface [polypeptide binding]; other site 572264006159 conserved gate region; other site 572264006160 ABC-ATPase subunit interface; other site 572264006161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264006162 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 572264006163 dimer interface [polypeptide binding]; other site 572264006164 conserved gate region; other site 572264006165 putative PBP binding loops; other site 572264006166 ABC-ATPase subunit interface; other site 572264006167 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572264006168 Beta-lactamase; Region: Beta-lactamase; pfam00144 572264006169 Erythromycin esterase; Region: Erythro_esteras; pfam05139 572264006170 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 572264006171 fructuronate transporter; Provisional; Region: PRK10034; cl15264 572264006172 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 572264006173 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 572264006174 active site 572264006175 Predicted flavoprotein [General function prediction only]; Region: COG0431 572264006176 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 572264006177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264006178 H+ Antiporter protein; Region: 2A0121; TIGR00900 572264006179 putative substrate translocation pore; other site 572264006180 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 572264006181 Uncharacterized conserved protein [Function unknown]; Region: COG1434 572264006182 putative active site [active] 572264006183 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 572264006184 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 572264006185 Walker A/P-loop; other site 572264006186 ATP binding site [chemical binding]; other site 572264006187 Q-loop/lid; other site 572264006188 ABC transporter signature motif; other site 572264006189 Walker B; other site 572264006190 D-loop; other site 572264006191 H-loop/switch region; other site 572264006192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264006193 dimer interface [polypeptide binding]; other site 572264006194 conserved gate region; other site 572264006195 ABC-ATPase subunit interface; other site 572264006196 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 572264006197 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 572264006198 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 572264006199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 572264006200 Protein of unknown function (DUF524); Region: DUF524; pfam04411 572264006201 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 572264006202 Helix-turn-helix domain; Region: HTH_17; cl17695 572264006203 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 572264006204 Domain of unknown function DUF21; Region: DUF21; pfam01595 572264006205 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 572264006206 Transporter associated domain; Region: CorC_HlyC; smart01091 572264006207 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 572264006208 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 572264006209 NAD(P) binding site [chemical binding]; other site 572264006210 catalytic residues [active] 572264006211 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 572264006212 Histidine kinase N terminal; Region: HisK_N; pfam09385 572264006213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264006214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264006215 dimer interface [polypeptide binding]; other site 572264006216 phosphorylation site [posttranslational modification] 572264006217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264006218 ATP binding site [chemical binding]; other site 572264006219 Mg2+ binding site [ion binding]; other site 572264006220 G-X-G motif; other site 572264006221 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 572264006222 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 572264006223 hypothetical protein; Provisional; Region: PRK06917 572264006224 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 572264006225 inhibitor-cofactor binding pocket; inhibition site 572264006226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264006227 catalytic residue [active] 572264006228 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 572264006229 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 572264006230 acetylornithine deacetylase; Validated; Region: PRK06915 572264006231 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 572264006232 metal binding site [ion binding]; metal-binding site 572264006233 dimer interface [polypeptide binding]; other site 572264006234 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 572264006235 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 572264006236 PAS fold; Region: PAS_4; pfam08448 572264006237 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 572264006238 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264006239 Walker A motif; other site 572264006240 ATP binding site [chemical binding]; other site 572264006241 Walker B motif; other site 572264006242 arginine finger; other site 572264006243 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 572264006244 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 572264006245 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572264006246 FeS/SAM binding site; other site 572264006247 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 572264006248 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 572264006249 toxin interface [polypeptide binding]; other site 572264006250 Zn binding site [ion binding]; other site 572264006251 hypothetical protein; Provisional; Region: PRK13672 572264006252 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 572264006253 YozD-like protein; Region: YozD; pfam14162 572264006254 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 572264006255 Catalytic domain of Protein Kinases; Region: PKc; cd00180 572264006256 active site 572264006257 ATP binding site [chemical binding]; other site 572264006258 substrate binding site [chemical binding]; other site 572264006259 activation loop (A-loop); other site 572264006260 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 572264006261 SpoOM protein; Region: Spo0M; pfam07070 572264006262 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 572264006263 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 572264006264 active site 572264006265 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 572264006266 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 572264006267 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 572264006268 catalytic residues [active] 572264006269 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 572264006270 homotrimer interaction site [polypeptide binding]; other site 572264006271 putative active site [active] 572264006272 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 572264006273 CHRD domain; Region: CHRD; pfam07452 572264006274 C1q domain; Region: C1q; cl17543 572264006275 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 572264006276 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 572264006277 YolD-like protein; Region: YolD; pfam08863 572264006278 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 572264006279 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 572264006280 classical (c) SDRs; Region: SDR_c; cd05233 572264006281 NAD(P) binding site [chemical binding]; other site 572264006282 active site 572264006283 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 572264006284 Transglycosylase; Region: Transgly; pfam00912 572264006285 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 572264006286 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572264006287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264006288 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264006289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264006290 putative substrate translocation pore; other site 572264006291 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 572264006292 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 572264006293 dimer interface [polypeptide binding]; other site 572264006294 Citrate synthase; Region: Citrate_synt; pfam00285 572264006295 active site 572264006296 coenzyme A binding site [chemical binding]; other site 572264006297 citrylCoA binding site [chemical binding]; other site 572264006298 oxalacetate/citrate binding site [chemical binding]; other site 572264006299 catalytic triad [active] 572264006300 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 572264006301 2-methylcitrate dehydratase; Region: prpD; TIGR02330 572264006302 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 572264006303 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 572264006304 tetramer interface [polypeptide binding]; other site 572264006305 active site 572264006306 Mg2+/Mn2+ binding site [ion binding]; other site 572264006307 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572264006308 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572264006309 active site 572264006310 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 572264006311 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 572264006312 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 572264006313 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 572264006314 tetrameric interface [polypeptide binding]; other site 572264006315 NAD binding site [chemical binding]; other site 572264006316 catalytic residues [active] 572264006317 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 572264006318 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 572264006319 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572264006320 substrate binding site [chemical binding]; other site 572264006321 oxyanion hole (OAH) forming residues; other site 572264006322 trimer interface [polypeptide binding]; other site 572264006323 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 572264006324 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 572264006325 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 572264006326 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 572264006327 active site 572264006328 metal binding site [ion binding]; metal-binding site 572264006329 DNA binding site [nucleotide binding] 572264006330 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 572264006331 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 572264006332 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 572264006333 Walker A/P-loop; other site 572264006334 ATP binding site [chemical binding]; other site 572264006335 Q-loop/lid; other site 572264006336 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 572264006337 ABC transporter signature motif; other site 572264006338 Walker B; other site 572264006339 D-loop; other site 572264006340 H-loop/switch region; other site 572264006341 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264006342 dimerization interface [polypeptide binding]; other site 572264006343 putative DNA binding site [nucleotide binding]; other site 572264006344 putative Zn2+ binding site [ion binding]; other site 572264006345 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 572264006346 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 572264006347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264006348 putative substrate translocation pore; other site 572264006349 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 572264006350 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 572264006351 putative NAD(P) binding site [chemical binding]; other site 572264006352 active site 572264006353 isochorismate synthase DhbC; Validated; Region: PRK06923 572264006354 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 572264006355 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 572264006356 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 572264006357 acyl-activating enzyme (AAE) consensus motif; other site 572264006358 active site 572264006359 AMP binding site [chemical binding]; other site 572264006360 substrate binding site [chemical binding]; other site 572264006361 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 572264006362 hydrophobic substrate binding pocket; other site 572264006363 Isochorismatase family; Region: Isochorismatase; pfam00857 572264006364 active site 572264006365 conserved cis-peptide bond; other site 572264006366 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 572264006367 Condensation domain; Region: Condensation; pfam00668 572264006368 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 572264006369 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 572264006370 acyl-activating enzyme (AAE) consensus motif; other site 572264006371 AMP binding site [chemical binding]; other site 572264006372 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 572264006373 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 572264006374 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 572264006375 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 572264006376 acyl-activating enzyme (AAE) consensus motif; other site 572264006377 AMP binding site [chemical binding]; other site 572264006378 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 572264006379 MbtH-like protein; Region: MbtH; cl01279 572264006380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264006381 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264006382 putative substrate translocation pore; other site 572264006383 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 572264006384 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 572264006385 Chorismate lyase; Region: Chor_lyase; cl01230 572264006386 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 572264006387 IHF dimer interface [polypeptide binding]; other site 572264006388 IHF - DNA interface [nucleotide binding]; other site 572264006389 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 572264006390 DinB family; Region: DinB; cl17821 572264006391 DinB superfamily; Region: DinB_2; pfam12867 572264006392 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 572264006393 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 572264006394 active site 572264006395 catalytic triad [active] 572264006396 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 572264006397 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 572264006398 Glycine riboswitch 572264006399 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 572264006400 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 572264006401 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572264006402 RNA binding surface [nucleotide binding]; other site 572264006403 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 572264006404 probable active site [active] 572264006405 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 572264006406 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 572264006407 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 572264006408 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 572264006409 active site 572264006410 dimer interface [polypeptide binding]; other site 572264006411 motif 1; other site 572264006412 motif 2; other site 572264006413 motif 3; other site 572264006414 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 572264006415 anticodon binding site; other site 572264006416 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 572264006417 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572264006418 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572264006419 Walker A/P-loop; other site 572264006420 ATP binding site [chemical binding]; other site 572264006421 Q-loop/lid; other site 572264006422 ABC transporter signature motif; other site 572264006423 Walker B; other site 572264006424 D-loop; other site 572264006425 H-loop/switch region; other site 572264006426 FtsX-like permease family; Region: FtsX; pfam02687 572264006427 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572264006428 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 572264006429 H+ Antiporter protein; Region: 2A0121; TIGR00900 572264006430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264006431 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 572264006432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264006433 dimer interface [polypeptide binding]; other site 572264006434 conserved gate region; other site 572264006435 ABC-ATPase subunit interface; other site 572264006436 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 572264006437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264006438 S-adenosylmethionine binding site [chemical binding]; other site 572264006439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 572264006440 Protein of unknown function (DUF2185); Region: DUF2185; pfam09951 572264006441 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572264006442 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 572264006443 active site 572264006444 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 572264006445 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 572264006446 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 572264006447 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572264006448 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264006449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264006450 MMPL family; Region: MMPL; pfam03176 572264006451 MMPL family; Region: MMPL; pfam03176 572264006452 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 572264006453 Chloramphenicol acetyltransferase; Region: CAT; pfam00302 572264006454 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 572264006455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264006456 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 572264006457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 572264006458 Coenzyme A binding pocket [chemical binding]; other site 572264006459 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 572264006460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264006461 Coenzyme A binding pocket [chemical binding]; other site 572264006462 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 572264006463 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 572264006464 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 572264006465 putative acetyltransferase YhhY; Provisional; Region: PRK10140 572264006466 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264006467 Coenzyme A binding pocket [chemical binding]; other site 572264006468 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 572264006469 EamA-like transporter family; Region: EamA; pfam00892 572264006470 EamA-like transporter family; Region: EamA; pfam00892 572264006471 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 572264006472 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264006473 non-specific DNA binding site [nucleotide binding]; other site 572264006474 salt bridge; other site 572264006475 sequence-specific DNA binding site [nucleotide binding]; other site 572264006476 Cupin domain; Region: Cupin_2; pfam07883 572264006477 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 572264006478 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 572264006479 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 572264006480 protoporphyrinogen oxidase; Provisional; Region: PRK12416 572264006481 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572264006482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264006483 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 572264006484 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 572264006485 Cold-inducible protein YdjO; Region: YdjO; pfam14169 572264006486 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 572264006487 DNA-binding site [nucleotide binding]; DNA binding site 572264006488 RNA-binding motif; other site 572264006489 CAAX protease self-immunity; Region: Abi; pfam02517 572264006490 AAA domain; Region: AAA_17; pfam13207 572264006491 AAA domain; Region: AAA_18; pfam13238 572264006492 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 572264006493 active site 572264006494 metal binding site [ion binding]; metal-binding site 572264006495 hypothetical protein; Provisional; Region: PRK06770 572264006496 Transcriptional regulator [Transcription]; Region: LysR; COG0583 572264006497 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572264006498 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 572264006499 dimerization interface [polypeptide binding]; other site 572264006500 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 572264006501 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 572264006502 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 572264006503 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 572264006504 active site 572264006505 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 572264006506 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 572264006507 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572264006508 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 572264006509 dimerization interface [polypeptide binding]; other site 572264006510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 572264006511 MOSC domain; Region: MOSC; pfam03473 572264006512 3-alpha domain; Region: 3-alpha; pfam03475 572264006513 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264006514 Coenzyme A binding pocket [chemical binding]; other site 572264006515 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 572264006516 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 572264006517 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 572264006518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264006519 Walker A/P-loop; other site 572264006520 ATP binding site [chemical binding]; other site 572264006521 Q-loop/lid; other site 572264006522 ABC transporter signature motif; other site 572264006523 Walker B; other site 572264006524 D-loop; other site 572264006525 H-loop/switch region; other site 572264006526 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 572264006527 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 572264006528 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 572264006529 Walker A/P-loop; other site 572264006530 ATP binding site [chemical binding]; other site 572264006531 Q-loop/lid; other site 572264006532 ABC transporter signature motif; other site 572264006533 Walker B; other site 572264006534 D-loop; other site 572264006535 H-loop/switch region; other site 572264006536 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 572264006537 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 572264006538 active site 572264006539 metal binding site [ion binding]; metal-binding site 572264006540 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 572264006541 LysE type translocator; Region: LysE; cl00565 572264006542 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 572264006543 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264006544 non-specific DNA binding site [nucleotide binding]; other site 572264006545 salt bridge; other site 572264006546 sequence-specific DNA binding site [nucleotide binding]; other site 572264006547 Cupin domain; Region: Cupin_2; pfam07883 572264006548 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 572264006549 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 572264006550 BclB C-terminal domain; Region: exospore_TM; TIGR03721 572264006551 Cupin; Region: Cupin_1; smart00835 572264006552 HD domain; Region: HD_4; pfam13328 572264006553 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 572264006554 metal binding triad [ion binding]; metal-binding site 572264006555 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 572264006556 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 572264006557 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572264006558 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 572264006559 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264006560 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 572264006561 Methyltransferase domain; Region: Methyltransf_31; pfam13847 572264006562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264006563 S-adenosylmethionine binding site [chemical binding]; other site 572264006564 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 572264006565 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 572264006566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 572264006567 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 572264006568 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 572264006569 active site 572264006570 P-loop; other site 572264006571 phosphorylation site [posttranslational modification] 572264006572 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 572264006573 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 572264006574 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 572264006575 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 572264006576 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 572264006577 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 572264006578 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 572264006579 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 572264006580 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572264006581 catalytic residue [active] 572264006582 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 572264006583 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 572264006584 tetramer interface [polypeptide binding]; other site 572264006585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264006586 catalytic residue [active] 572264006587 Uncharacterized conserved protein [Function unknown]; Region: COG3339 572264006588 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 572264006589 Proteins of 100 residues with WXG; Region: WXG100; cl02005 572264006590 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572264006591 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 572264006592 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 572264006593 ATP binding site [chemical binding]; other site 572264006594 Mg++ binding site [ion binding]; other site 572264006595 motif III; other site 572264006596 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572264006597 nucleotide binding region [chemical binding]; other site 572264006598 ATP-binding site [chemical binding]; other site 572264006599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264006600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264006601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264006602 H+ Antiporter protein; Region: 2A0121; TIGR00900 572264006603 putative substrate translocation pore; other site 572264006604 FtsX-like permease family; Region: FtsX; pfam02687 572264006605 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572264006606 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572264006607 Walker A/P-loop; other site 572264006608 ATP binding site [chemical binding]; other site 572264006609 Q-loop/lid; other site 572264006610 ABC transporter signature motif; other site 572264006611 Walker B; other site 572264006612 D-loop; other site 572264006613 H-loop/switch region; other site 572264006614 Methyltransferase domain; Region: Methyltransf_23; pfam13489 572264006615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264006616 S-adenosylmethionine binding site [chemical binding]; other site 572264006617 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 572264006618 dimer interface [polypeptide binding]; other site 572264006619 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 572264006620 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 572264006621 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 572264006622 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 572264006623 Int/Topo IB signature motif; other site 572264006624 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 572264006625 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 572264006626 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 572264006627 C1q domain; Region: C1q; cl17543 572264006628 Protein of unknown function (DUF3983); Region: DUF3983; pfam13137 572264006629 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 572264006630 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 572264006631 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 572264006632 Cytochrome P450; Region: p450; cl12078 572264006633 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 572264006634 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 572264006635 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 572264006636 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 572264006637 MarR family; Region: MarR_2; pfam12802 572264006638 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572264006639 catalytic core [active] 572264006640 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 572264006641 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 572264006642 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 572264006643 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 572264006644 metal binding site [ion binding]; metal-binding site 572264006645 dimer interface [polypeptide binding]; other site 572264006646 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 572264006647 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 572264006648 trimer interface [polypeptide binding]; other site 572264006649 active site 572264006650 substrate binding site [chemical binding]; other site 572264006651 CoA binding site [chemical binding]; other site 572264006652 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 572264006653 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 572264006654 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 572264006655 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 572264006656 active site 572264006657 catalytic triad [active] 572264006658 oxyanion hole [active] 572264006659 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 572264006660 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 572264006661 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 572264006662 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572264006663 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 572264006664 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264006665 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572264006666 DNA binding residues [nucleotide binding] 572264006667 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 572264006668 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 572264006669 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572264006670 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 572264006671 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 572264006672 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 572264006673 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572264006674 beta-lactamase TEM; Provisional; Region: PRK15442 572264006675 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 572264006676 Transcriptional regulators [Transcription]; Region: PurR; COG1609 572264006677 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 572264006678 DNA binding site [nucleotide binding] 572264006679 domain linker motif; other site 572264006680 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 572264006681 dimerization interface [polypeptide binding]; other site 572264006682 ligand binding site [chemical binding]; other site 572264006683 polyol permease family; Region: 2A0118; TIGR00897 572264006684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264006685 putative substrate translocation pore; other site 572264006686 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 572264006687 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 572264006688 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 572264006689 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 572264006690 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 572264006691 substrate binding site [chemical binding]; other site 572264006692 ATP binding site [chemical binding]; other site 572264006693 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 572264006694 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 572264006695 tetrameric interface [polypeptide binding]; other site 572264006696 NAD binding site [chemical binding]; other site 572264006697 catalytic residues [active] 572264006698 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 572264006699 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 572264006700 PYR/PP interface [polypeptide binding]; other site 572264006701 dimer interface [polypeptide binding]; other site 572264006702 TPP binding site [chemical binding]; other site 572264006703 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 572264006704 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 572264006705 TPP-binding site; other site 572264006706 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 572264006707 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 572264006708 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 572264006709 intersubunit interface [polypeptide binding]; other site 572264006710 active site 572264006711 zinc binding site [ion binding]; other site 572264006712 Na+ binding site [ion binding]; other site 572264006713 KduI/IolB family; Region: KduI; pfam04962 572264006714 DinB superfamily; Region: DinB_2; pfam12867 572264006715 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 572264006716 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 572264006717 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 572264006718 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 572264006719 active site 572264006720 metal binding site [ion binding]; metal-binding site 572264006721 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 572264006722 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264006723 TPR motif; other site 572264006724 binding surface 572264006725 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264006726 non-specific DNA binding site [nucleotide binding]; other site 572264006727 salt bridge; other site 572264006728 sequence-specific DNA binding site [nucleotide binding]; other site 572264006729 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 572264006730 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 572264006731 S-layer homology domain; Region: SLH; pfam00395 572264006732 S-layer homology domain; Region: SLH; pfam00395 572264006733 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 572264006734 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 572264006735 active site 572264006736 metal binding site [ion binding]; metal-binding site 572264006737 beta-channel forming cytolysin; Region: hlyII; TIGR01002 572264006738 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264006739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264006740 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 572264006741 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264006742 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264006743 PAS fold; Region: PAS_4; pfam08448 572264006744 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572264006745 putative active site [active] 572264006746 heme pocket [chemical binding]; other site 572264006747 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572264006748 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572264006749 metal binding site [ion binding]; metal-binding site 572264006750 active site 572264006751 I-site; other site 572264006752 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572264006753 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 572264006754 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 572264006755 Tar ligand binding domain homologue; Region: TarH; pfam02203 572264006756 Cache domain; Region: Cache_1; pfam02743 572264006757 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264006758 dimerization interface [polypeptide binding]; other site 572264006759 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572264006760 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572264006761 dimer interface [polypeptide binding]; other site 572264006762 putative CheW interface [polypeptide binding]; other site 572264006763 Homeodomain-like domain; Region: HTH_23; cl17451 572264006764 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 572264006765 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572264006766 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 572264006767 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 572264006768 active site residue [active] 572264006769 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 572264006770 active site residue [active] 572264006771 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 572264006772 Protein of unknown function (DUF523); Region: DUF523; pfam04463 572264006773 Uncharacterized conserved protein [Function unknown]; Region: COG3272 572264006774 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 572264006775 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572264006776 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 572264006777 FAD binding site [chemical binding]; other site 572264006778 homotetramer interface [polypeptide binding]; other site 572264006779 substrate binding pocket [chemical binding]; other site 572264006780 catalytic base [active] 572264006781 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 572264006782 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 572264006783 ATP-grasp domain; Region: ATP-grasp_4; cl17255 572264006784 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 572264006785 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 572264006786 carboxyltransferase (CT) interaction site; other site 572264006787 biotinylation site [posttranslational modification]; other site 572264006788 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 572264006789 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 572264006790 active site 572264006791 catalytic residues [active] 572264006792 metal binding site [ion binding]; metal-binding site 572264006793 enoyl-CoA hydratase; Provisional; Region: PRK07657 572264006794 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572264006795 substrate binding site [chemical binding]; other site 572264006796 oxyanion hole (OAH) forming residues; other site 572264006797 trimer interface [polypeptide binding]; other site 572264006798 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 572264006799 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 572264006800 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 572264006801 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 572264006802 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 572264006803 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 572264006804 acyl-activating enzyme (AAE) consensus motif; other site 572264006805 putative AMP binding site [chemical binding]; other site 572264006806 putative active site [active] 572264006807 putative CoA binding site [chemical binding]; other site 572264006808 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 572264006809 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264006810 Coenzyme A binding pocket [chemical binding]; other site 572264006811 hypothetical protein; Provisional; Region: PRK08233 572264006812 AAA domain; Region: AAA_18; pfam13238 572264006813 active site 572264006814 DinB family; Region: DinB; cl17821 572264006815 DinB superfamily; Region: DinB_2; pfam12867 572264006816 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 572264006817 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 572264006818 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264006819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264006820 dimer interface [polypeptide binding]; other site 572264006821 phosphorylation site [posttranslational modification] 572264006822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264006823 ATP binding site [chemical binding]; other site 572264006824 Mg2+ binding site [ion binding]; other site 572264006825 G-X-G motif; other site 572264006826 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264006827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264006828 active site 572264006829 phosphorylation site [posttranslational modification] 572264006830 intermolecular recognition site; other site 572264006831 dimerization interface [polypeptide binding]; other site 572264006832 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264006833 DNA binding site [nucleotide binding] 572264006834 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 572264006835 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 572264006836 S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714 572264006837 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 572264006838 NADH(P)-binding; Region: NAD_binding_10; pfam13460 572264006839 NAD binding site [chemical binding]; other site 572264006840 substrate binding site [chemical binding]; other site 572264006841 putative active site [active] 572264006842 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 572264006843 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264006844 Coenzyme A binding pocket [chemical binding]; other site 572264006845 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264006846 Coenzyme A binding pocket [chemical binding]; other site 572264006847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 572264006848 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 572264006849 putative hydrophobic ligand binding site [chemical binding]; other site 572264006850 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264006851 AAA domain; Region: AAA_21; pfam13304 572264006852 Walker A/P-loop; other site 572264006853 ATP binding site [chemical binding]; other site 572264006854 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264006855 ABC transporter signature motif; other site 572264006856 Walker B; other site 572264006857 D-loop; other site 572264006858 H-loop/switch region; other site 572264006859 ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238 572264006860 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 572264006861 Restriction endonuclease XhoI; Region: XhoI; pfam04555 572264006862 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 572264006863 Predicted transcriptional regulators [Transcription]; Region: COG1695 572264006864 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 572264006865 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572264006866 Beta-lactamase; Region: Beta-lactamase; pfam00144 572264006867 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 572264006868 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 572264006869 DNA binding residues [nucleotide binding] 572264006870 drug binding residues [chemical binding]; other site 572264006871 dimer interface [polypeptide binding]; other site 572264006872 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 572264006873 H+ Antiporter protein; Region: 2A0121; TIGR00900 572264006874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264006875 putative substrate translocation pore; other site 572264006876 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 572264006877 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 572264006878 active site 572264006879 ATP binding site [chemical binding]; other site 572264006880 substrate binding site [chemical binding]; other site 572264006881 activation loop (A-loop); other site 572264006882 Methyltransferase domain; Region: Methyltransf_31; pfam13847 572264006883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264006884 S-adenosylmethionine binding site [chemical binding]; other site 572264006885 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 572264006886 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 572264006887 Phosphotransferase enzyme family; Region: APH; pfam01636 572264006888 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 572264006889 active site 572264006890 substrate binding site [chemical binding]; other site 572264006891 ATP binding site [chemical binding]; other site 572264006892 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 572264006893 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 572264006894 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 572264006895 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 572264006896 active site 572264006897 Zn binding site [ion binding]; other site 572264006898 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 572264006899 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 572264006900 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572264006901 DNA-binding site [nucleotide binding]; DNA binding site 572264006902 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572264006903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264006904 homodimer interface [polypeptide binding]; other site 572264006905 catalytic residue [active] 572264006906 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 572264006907 Methyltransferase domain; Region: Methyltransf_31; pfam13847 572264006908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264006909 S-adenosylmethionine binding site [chemical binding]; other site 572264006910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264006911 S-adenosylmethionine binding site [chemical binding]; other site 572264006912 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 572264006913 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 572264006914 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 572264006915 active site 572264006916 HIGH motif; other site 572264006917 KMSKS motif; other site 572264006918 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 572264006919 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 572264006920 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264006921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264006922 active site 572264006923 phosphorylation site [posttranslational modification] 572264006924 intermolecular recognition site; other site 572264006925 dimerization interface [polypeptide binding]; other site 572264006926 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264006927 DNA binding site [nucleotide binding] 572264006928 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264006929 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 572264006930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264006931 ATP binding site [chemical binding]; other site 572264006932 Mg2+ binding site [ion binding]; other site 572264006933 G-X-G motif; other site 572264006934 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 572264006935 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 572264006936 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264006937 ABC transporter; Region: ABC_tran_2; pfam12848 572264006938 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264006939 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572264006940 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572264006941 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 572264006942 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 572264006943 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572264006944 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572264006945 Walker A/P-loop; other site 572264006946 ATP binding site [chemical binding]; other site 572264006947 Q-loop/lid; other site 572264006948 ABC transporter signature motif; other site 572264006949 Walker B; other site 572264006950 D-loop; other site 572264006951 H-loop/switch region; other site 572264006952 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 572264006953 FtsX-like permease family; Region: FtsX; pfam02687 572264006954 hypothetical protein; Provisional; Region: PRK06760 572264006955 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 572264006956 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 572264006957 homoserine dehydrogenase; Validated; Region: PRK06813 572264006958 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 572264006959 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 572264006960 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572264006961 DNA-binding site [nucleotide binding]; DNA binding site 572264006962 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572264006963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264006964 homodimer interface [polypeptide binding]; other site 572264006965 catalytic residue [active] 572264006966 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 572264006967 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 572264006968 ATP-grasp domain; Region: ATP-grasp_4; cl17255 572264006969 Putative transcription activator [Transcription]; Region: TenA; COG0819 572264006970 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 572264006971 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 572264006972 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105 572264006973 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 572264006974 Protein of unknown function; Region: DUF3658; pfam12395 572264006975 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 572264006976 Cytochrome P450; Region: p450; cl12078 572264006977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264006978 H+ Antiporter protein; Region: 2A0121; TIGR00900 572264006979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264006980 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 572264006981 trimer interface [polypeptide binding]; other site 572264006982 active site 572264006983 substrate binding site [chemical binding]; other site 572264006984 CoA binding site [chemical binding]; other site 572264006985 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 572264006986 Predicted transcriptional regulators [Transcription]; Region: COG1695 572264006987 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 572264006988 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 572264006989 Cytochrome P450; Region: p450; cl12078 572264006990 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 572264006991 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264006992 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 572264006993 active site 572264006994 motif I; other site 572264006995 motif II; other site 572264006996 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264006997 PAS domain S-box; Region: sensory_box; TIGR00229 572264006998 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572264006999 putative active site [active] 572264007000 heme pocket [chemical binding]; other site 572264007001 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 572264007002 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264007003 dimer interface [polypeptide binding]; other site 572264007004 phosphorylation site [posttranslational modification] 572264007005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264007006 ATP binding site [chemical binding]; other site 572264007007 Mg2+ binding site [ion binding]; other site 572264007008 G-X-G motif; other site 572264007009 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 572264007010 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 572264007011 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 572264007012 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572264007013 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 572264007014 glycosyltransferase, MGT family; Region: MGT; TIGR01426 572264007015 active site 572264007016 TDP-binding site; other site 572264007017 acceptor substrate-binding pocket; other site 572264007018 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 572264007019 aspartate racemase; Region: asp_race; TIGR00035 572264007020 hypothetical protein; Provisional; Region: PRK13661 572264007021 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13644 572264007022 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 572264007023 Walker A/P-loop; other site 572264007024 ATP binding site [chemical binding]; other site 572264007025 Q-loop/lid; other site 572264007026 ABC transporter signature motif; other site 572264007027 Walker B; other site 572264007028 D-loop; other site 572264007029 H-loop/switch region; other site 572264007030 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 572264007031 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 572264007032 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 572264007033 Walker A/P-loop; other site 572264007034 ATP binding site [chemical binding]; other site 572264007035 Q-loop/lid; other site 572264007036 ABC transporter signature motif; other site 572264007037 Walker B; other site 572264007038 D-loop; other site 572264007039 H-loop/switch region; other site 572264007040 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 572264007041 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 572264007042 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264007043 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264007044 dimer interface [polypeptide binding]; other site 572264007045 phosphorylation site [posttranslational modification] 572264007046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264007047 ATP binding site [chemical binding]; other site 572264007048 Mg2+ binding site [ion binding]; other site 572264007049 G-X-G motif; other site 572264007050 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 572264007051 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 572264007052 active site 572264007053 ATP binding site [chemical binding]; other site 572264007054 substrate binding site [chemical binding]; other site 572264007055 activation loop (A-loop); other site 572264007056 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 572264007057 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 572264007058 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 572264007059 NAD(P) binding site [chemical binding]; other site 572264007060 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 572264007061 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 572264007062 active site 572264007063 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 572264007064 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 572264007065 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572264007066 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 572264007067 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 572264007068 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264007069 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264007070 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 572264007071 classical (c) SDRs; Region: SDR_c; cd05233 572264007072 short chain dehydrogenase; Provisional; Region: PRK07832 572264007073 NAD(P) binding site [chemical binding]; other site 572264007074 active site 572264007075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264007076 H+ Antiporter protein; Region: 2A0121; TIGR00900 572264007077 putative substrate translocation pore; other site 572264007078 Beta-lactamase; Region: Beta-lactamase; pfam00144 572264007079 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572264007080 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264007081 Coenzyme A binding pocket [chemical binding]; other site 572264007082 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 572264007083 EDD domain protein, DegV family; Region: DegV; TIGR00762 572264007084 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 572264007085 Putative amidotransferase; Region: DUF4066; pfam13278 572264007086 conserved cys residue [active] 572264007087 Predicted transcriptional regulator [Transcription]; Region: COG2378 572264007088 HTH domain; Region: HTH_11; pfam08279 572264007089 WYL domain; Region: WYL; pfam13280 572264007090 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 572264007091 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 572264007092 conserved cys residue [active] 572264007093 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572264007094 Beta-lactamase; Region: Beta-lactamase; pfam00144 572264007095 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777 572264007096 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 572264007097 DNA binding residues [nucleotide binding] 572264007098 putative dimer interface [polypeptide binding]; other site 572264007099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264007100 S-adenosylmethionine binding site [chemical binding]; other site 572264007101 H+ Antiporter protein; Region: 2A0121; TIGR00900 572264007102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264007103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264007104 Coenzyme A binding pocket [chemical binding]; other site 572264007105 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 572264007106 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 572264007107 active site 572264007108 catalytic site [active] 572264007109 metal binding site [ion binding]; metal-binding site 572264007110 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 572264007111 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 572264007112 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572264007113 DNA-binding site [nucleotide binding]; DNA binding site 572264007114 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572264007115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264007116 homodimer interface [polypeptide binding]; other site 572264007117 catalytic residue [active] 572264007118 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 572264007119 EamA-like transporter family; Region: EamA; pfam00892 572264007120 EamA-like transporter family; Region: EamA; pfam00892 572264007121 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 572264007122 Coenzyme A binding pocket [chemical binding]; other site 572264007123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 572264007124 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 572264007125 nudix motif; other site 572264007126 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 572264007127 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 572264007128 Beta-lactamase; Region: Beta-lactamase; pfam00144 572264007129 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572264007130 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 572264007131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264007132 putative substrate translocation pore; other site 572264007133 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 572264007134 nudix motif; other site 572264007135 DNA polymerase III subunit beta; Validated; Region: PRK06673 572264007136 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 572264007137 putative DNA binding surface [nucleotide binding]; other site 572264007138 dimer interface [polypeptide binding]; other site 572264007139 beta-clamp/clamp loader binding surface; other site 572264007140 beta-clamp/translesion DNA polymerase binding surface; other site 572264007141 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 572264007142 putative active site [active] 572264007143 nucleotide binding site [chemical binding]; other site 572264007144 nudix motif; other site 572264007145 putative metal binding site [ion binding]; other site 572264007146 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572264007147 translation initiation factor IF-2; Provisional; Region: PRK14845 572264007148 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572264007149 catalytic core [active] 572264007150 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 572264007151 homotrimer interaction site [polypeptide binding]; other site 572264007152 putative active site [active] 572264007153 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 572264007154 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 572264007155 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 572264007156 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 572264007157 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 572264007158 YxiJ-like protein; Region: YxiJ; pfam14176 572264007159 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 572264007160 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 572264007161 active site 572264007162 nucleophile elbow; other site 572264007163 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 572264007164 pentamer interface [polypeptide binding]; other site 572264007165 dodecaamer interface [polypeptide binding]; other site 572264007166 metal-dependent hydrolase; Provisional; Region: PRK13291 572264007167 DinB superfamily; Region: DinB_2; pfam12867 572264007168 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572264007169 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 572264007170 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 572264007171 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 572264007172 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 572264007173 GIY-YIG motif/motif A; other site 572264007174 active site 572264007175 catalytic site [active] 572264007176 putative DNA binding site [nucleotide binding]; other site 572264007177 metal binding site [ion binding]; metal-binding site 572264007178 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572264007179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264007180 Coenzyme A binding pocket [chemical binding]; other site 572264007181 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 572264007182 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 572264007183 active site 572264007184 ATP binding site [chemical binding]; other site 572264007185 substrate binding site [chemical binding]; other site 572264007186 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 572264007187 nudix motif; other site 572264007188 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 572264007189 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572264007190 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 572264007191 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 572264007192 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 572264007193 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264007194 motif II; other site 572264007195 DinB superfamily; Region: DinB_2; pfam12867 572264007196 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 572264007197 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 572264007198 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 572264007199 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 572264007200 active site 572264007201 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 572264007202 carbohydrate binding site [chemical binding]; other site 572264007203 pullulanase, type I; Region: pulA_typeI; TIGR02104 572264007204 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 572264007205 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 572264007206 Ca binding site [ion binding]; other site 572264007207 active site 572264007208 catalytic site [active] 572264007209 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 572264007210 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 572264007211 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 572264007212 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 572264007213 active site 572264007214 Zn binding site [ion binding]; other site 572264007215 Putative zinc-finger; Region: zf-HC2; pfam13490 572264007216 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 572264007217 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 572264007218 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264007219 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572264007220 DNA binding residues [nucleotide binding] 572264007221 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 572264007222 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 572264007223 active site 572264007224 metal binding site [ion binding]; metal-binding site 572264007225 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572264007226 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 572264007227 SecY translocase; Region: SecY; pfam00344 572264007228 hypothetical protein; Validated; Region: PRK06672 572264007229 DnaA N-terminal domain; Region: DnaA_N; pfam11638 572264007230 DnaA N-terminal domain; Region: DnaA_N; pfam11638 572264007231 DnaA N-terminal domain; Region: DnaA_N; pfam11638 572264007232 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 572264007233 EamA-like transporter family; Region: EamA; pfam00892 572264007234 EamA-like transporter family; Region: EamA; pfam00892 572264007235 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 572264007236 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572264007237 DNA-binding site [nucleotide binding]; DNA binding site 572264007238 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572264007239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264007240 homodimer interface [polypeptide binding]; other site 572264007241 catalytic residue [active] 572264007242 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572264007243 TAP-like protein; Region: Abhydrolase_4; pfam08386 572264007244 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 572264007245 Mg binding site [ion binding]; other site 572264007246 nucleotide binding site [chemical binding]; other site 572264007247 putative protofilament interface [polypeptide binding]; other site 572264007248 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 572264007249 Predicted membrane protein [Function unknown]; Region: COG4129 572264007250 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 572264007251 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 572264007252 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 572264007253 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 572264007254 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 572264007255 germination protein YpeB; Region: spore_YpeB; TIGR02889 572264007256 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 572264007257 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 572264007258 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 572264007259 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 572264007260 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572264007261 Beta-lactamase; Region: Beta-lactamase; pfam00144 572264007262 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 572264007263 arylformamidase; Region: trp_arylform; TIGR03035 572264007264 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 572264007265 kynureninase; Region: kynureninase; TIGR01814 572264007266 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572264007267 catalytic residue [active] 572264007268 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264007269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264007270 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 572264007271 nudix motif; other site 572264007272 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 572264007273 hydrophobic ligand binding site; other site 572264007274 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 572264007275 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 572264007276 GAF domain; Region: GAF; pfam01590 572264007277 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264007278 Walker A motif; other site 572264007279 ATP binding site [chemical binding]; other site 572264007280 Walker B motif; other site 572264007281 arginine finger; other site 572264007282 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 572264007283 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 572264007284 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 572264007285 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264007286 Coenzyme A binding pocket [chemical binding]; other site 572264007287 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 572264007288 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 572264007289 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 572264007290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264007291 S-adenosylmethionine binding site [chemical binding]; other site 572264007292 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 572264007293 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572264007294 Rrf2 family protein; Region: rrf2_super; TIGR00738 572264007295 Transcriptional regulator; Region: Rrf2; pfam02082 572264007296 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 572264007297 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 572264007298 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572264007299 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572264007300 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 572264007301 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 572264007302 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 572264007303 E3 interaction surface; other site 572264007304 lipoyl attachment site [posttranslational modification]; other site 572264007305 e3 binding domain; Region: E3_binding; pfam02817 572264007306 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 572264007307 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 572264007308 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 572264007309 alpha subunit interface [polypeptide binding]; other site 572264007310 TPP binding site [chemical binding]; other site 572264007311 heterodimer interface [polypeptide binding]; other site 572264007312 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 572264007313 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 572264007314 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 572264007315 tetramer interface [polypeptide binding]; other site 572264007316 TPP-binding site [chemical binding]; other site 572264007317 heterodimer interface [polypeptide binding]; other site 572264007318 phosphorylation loop region [posttranslational modification] 572264007319 DinB superfamily; Region: DinB_2; pfam12867 572264007320 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 572264007321 short chain dehydrogenase; Provisional; Region: PRK06914 572264007322 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 572264007323 NADP binding site [chemical binding]; other site 572264007324 active site 572264007325 steroid binding site; other site 572264007326 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 572264007327 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 572264007328 AAA domain; Region: AAA_18; pfam13238 572264007329 active site 572264007330 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 572264007331 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 572264007332 nudix motif; other site 572264007333 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 572264007334 Protein phosphatase 2C; Region: PP2C_2; pfam13672 572264007335 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 572264007336 nucleotide binding site/active site [active] 572264007337 HIT family signature motif; other site 572264007338 catalytic residue [active] 572264007339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264007340 dimer interface [polypeptide binding]; other site 572264007341 conserved gate region; other site 572264007342 putative PBP binding loops; other site 572264007343 ABC-ATPase subunit interface; other site 572264007344 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 572264007345 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 572264007346 Walker A/P-loop; other site 572264007347 ATP binding site [chemical binding]; other site 572264007348 Q-loop/lid; other site 572264007349 ABC transporter signature motif; other site 572264007350 Walker B; other site 572264007351 D-loop; other site 572264007352 H-loop/switch region; other site 572264007353 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 572264007354 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 572264007355 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 572264007356 Clp protease; Region: CLP_protease; pfam00574 572264007357 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 572264007358 oligomer interface [polypeptide binding]; other site 572264007359 active site residues [active] 572264007360 RNA polymerase factor sigma-70; Validated; Region: PRK06704 572264007361 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264007362 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 572264007363 DNA binding residues [nucleotide binding] 572264007364 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 572264007365 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 572264007366 catalytic loop [active] 572264007367 iron binding site [ion binding]; other site 572264007368 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 572264007369 tetramer (dimer of dimers) interface [polypeptide binding]; other site 572264007370 active site 572264007371 dimer interface [polypeptide binding]; other site 572264007372 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264007373 Coenzyme A binding pocket [chemical binding]; other site 572264007374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 572264007375 Chitin binding domain; Region: Chitin_bind_3; pfam03067 572264007376 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 572264007377 Interdomain contacts; other site 572264007378 Cytokine receptor motif; other site 572264007379 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 572264007380 Interdomain contacts; other site 572264007381 Cytokine receptor motif; other site 572264007382 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 572264007383 topology modulation protein; Reviewed; Region: PRK08118 572264007384 AAA domain; Region: AAA_17; pfam13207 572264007385 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 572264007386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264007387 S-adenosylmethionine binding site [chemical binding]; other site 572264007388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 572264007389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264007390 Coenzyme A binding pocket [chemical binding]; other site 572264007391 S-layer homology domain; Region: SLH; pfam00395 572264007392 S-layer homology domain; Region: SLH; pfam00395 572264007393 S-layer homology domain; Region: SLH; pfam00395 572264007394 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 572264007395 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572264007396 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 572264007397 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 572264007398 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 572264007399 active site 572264007400 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 572264007401 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264007402 Coenzyme A binding pocket [chemical binding]; other site 572264007403 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 572264007404 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 572264007405 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264007406 Coenzyme A binding pocket [chemical binding]; other site 572264007407 Predicted transcriptional regulators [Transcription]; Region: COG1695 572264007408 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 572264007409 Protein of unknown function (DUF952); Region: DUF952; pfam06108 572264007410 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 572264007411 Part of AAA domain; Region: AAA_19; pfam13245 572264007412 Family description; Region: UvrD_C_2; pfam13538 572264007413 CAAX protease self-immunity; Region: Abi; pfam02517 572264007414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264007415 S-adenosylmethionine binding site [chemical binding]; other site 572264007416 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 572264007417 putative active site pocket [active] 572264007418 dimerization interface [polypeptide binding]; other site 572264007419 putative catalytic residue [active] 572264007420 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 572264007421 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572264007422 ATP binding site [chemical binding]; other site 572264007423 putative Mg++ binding site [ion binding]; other site 572264007424 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572264007425 nucleotide binding region [chemical binding]; other site 572264007426 ATP-binding site [chemical binding]; other site 572264007427 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 572264007428 HRDC domain; Region: HRDC; pfam00570 572264007429 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 572264007430 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 572264007431 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 572264007432 active site 572264007433 Zn binding site [ion binding]; other site 572264007434 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 572264007435 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 572264007436 DHHA2 domain; Region: DHHA2; pfam02833 572264007437 Chitin binding domain; Region: Chitin_bind_3; pfam03067 572264007438 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 572264007439 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264007440 Coenzyme A binding pocket [chemical binding]; other site 572264007441 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 572264007442 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 572264007443 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 572264007444 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 572264007445 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 572264007446 NAD(P) binding site [chemical binding]; other site 572264007447 catalytic residues [active] 572264007448 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 572264007449 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 572264007450 inhibitor site; inhibition site 572264007451 active site 572264007452 dimer interface [polypeptide binding]; other site 572264007453 catalytic residue [active] 572264007454 Proline racemase; Region: Pro_racemase; pfam05544 572264007455 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 572264007456 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 572264007457 Proline racemase; Region: Pro_racemase; pfam05544 572264007458 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 572264007459 hydroxyglutarate oxidase; Provisional; Region: PRK11728 572264007460 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 572264007461 PAS domain; Region: PAS_10; pfam13596 572264007462 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 572264007463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264007464 Walker A motif; other site 572264007465 ATP binding site [chemical binding]; other site 572264007466 Walker B motif; other site 572264007467 arginine finger; other site 572264007468 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 572264007469 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 572264007470 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264007471 Walker A/P-loop; other site 572264007472 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 572264007473 catalytic loop [active] 572264007474 iron binding site [ion binding]; other site 572264007475 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 572264007476 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572264007477 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 572264007478 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 572264007479 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 572264007480 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 572264007481 DinB superfamily; Region: DinB_2; pfam12867 572264007482 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 572264007483 DltD N-terminal region; Region: DltD_N; pfam04915 572264007484 DltD central region; Region: DltD_M; pfam04918 572264007485 DltD C-terminal region; Region: DltD_C; pfam04914 572264007486 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572264007487 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 572264007488 Coenzyme A binding pocket [chemical binding]; other site 572264007489 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 572264007490 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 572264007491 peptide binding site [polypeptide binding]; other site 572264007492 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 572264007493 NlpC/P60 family; Region: NLPC_P60; pfam00877 572264007494 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 572264007495 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 572264007496 active site 572264007497 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 572264007498 Septum formation initiator; Region: DivIC; pfam04977 572264007499 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 572264007500 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 572264007501 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 572264007502 active site 572264007503 catalytic motif [active] 572264007504 Zn binding site [ion binding]; other site 572264007505 Methyltransferase domain; Region: Methyltransf_23; pfam13489 572264007506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264007507 S-adenosylmethionine binding site [chemical binding]; other site 572264007508 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 572264007509 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 572264007510 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264007511 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264007512 dimerization interface [polypeptide binding]; other site 572264007513 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264007514 dimer interface [polypeptide binding]; other site 572264007515 phosphorylation site [posttranslational modification] 572264007516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264007517 ATP binding site [chemical binding]; other site 572264007518 Mg2+ binding site [ion binding]; other site 572264007519 G-X-G motif; other site 572264007520 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264007521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264007522 active site 572264007523 phosphorylation site [posttranslational modification] 572264007524 intermolecular recognition site; other site 572264007525 dimerization interface [polypeptide binding]; other site 572264007526 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264007527 DNA binding site [nucleotide binding] 572264007528 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 572264007529 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Validated; Region: PRK06698 572264007530 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Provisional; Region: PRK14697 572264007531 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264007532 motif II; other site 572264007533 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 572264007534 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 572264007535 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 572264007536 Zn binding site [ion binding]; other site 572264007537 Spore germination protein; Region: Spore_permease; cl17796 572264007538 putative transporter; Provisional; Region: PRK11021 572264007539 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 572264007540 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264007541 putative DNA binding site [nucleotide binding]; other site 572264007542 putative Zn2+ binding site [ion binding]; other site 572264007543 AsnC family; Region: AsnC_trans_reg; pfam01037 572264007544 EDD domain protein, DegV family; Region: DegV; TIGR00762 572264007545 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 572264007546 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 572264007547 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 572264007548 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 572264007549 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264007550 Coenzyme A binding pocket [chemical binding]; other site 572264007551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264007552 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264007553 putative substrate translocation pore; other site 572264007554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264007555 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 572264007556 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 572264007557 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 572264007558 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 572264007559 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 572264007560 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 572264007561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264007562 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264007563 putative substrate translocation pore; other site 572264007564 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 572264007565 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 572264007566 active site 572264007567 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 572264007568 Methyltransferase domain; Region: Methyltransf_31; pfam13847 572264007569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264007570 S-adenosylmethionine binding site [chemical binding]; other site 572264007571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264007572 putative substrate translocation pore; other site 572264007573 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264007574 aspartate aminotransferase; Provisional; Region: PRK07681 572264007575 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572264007576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264007577 homodimer interface [polypeptide binding]; other site 572264007578 catalytic residue [active] 572264007579 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 572264007580 pantothenate kinase; Provisional; Region: PRK13317 572264007581 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 572264007582 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 572264007583 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 572264007584 Protein of unknown function (DUF4052); Region: DUF4052; pfam13261 572264007585 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 572264007586 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264007587 Walker A/P-loop; other site 572264007588 ATP binding site [chemical binding]; other site 572264007589 Q-loop/lid; other site 572264007590 ABC transporter signature motif; other site 572264007591 Walker B; other site 572264007592 D-loop; other site 572264007593 H-loop/switch region; other site 572264007594 Predicted transcriptional regulators [Transcription]; Region: COG1725 572264007595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572264007596 DNA-binding site [nucleotide binding]; DNA binding site 572264007597 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 572264007598 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 572264007599 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 572264007600 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 572264007601 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 572264007602 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 572264007603 Domain of unknown function DUF20; Region: UPF0118; pfam01594 572264007604 HNH endonuclease; Region: HNH_5; pfam14279 572264007605 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 572264007606 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 572264007607 active site 572264007608 dimer interface [polypeptide binding]; other site 572264007609 non-prolyl cis peptide bond; other site 572264007610 insertion regions; other site 572264007611 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 572264007612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 572264007613 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 572264007614 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572264007615 substrate binding pocket [chemical binding]; other site 572264007616 membrane-bound complex binding site; other site 572264007617 hinge residues; other site 572264007618 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 572264007619 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 572264007620 Walker A/P-loop; other site 572264007621 ATP binding site [chemical binding]; other site 572264007622 Q-loop/lid; other site 572264007623 ABC transporter signature motif; other site 572264007624 Walker B; other site 572264007625 D-loop; other site 572264007626 H-loop/switch region; other site 572264007627 Protein of unknown function (DUF402); Region: DUF402; pfam04167 572264007628 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 572264007629 nudix motif; other site 572264007630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 572264007631 binding surface 572264007632 TPR motif; other site 572264007633 hypothetical protein; Provisional; Region: PRK09620 572264007634 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 572264007635 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 572264007636 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 572264007637 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 572264007638 Coenzyme A binding pocket [chemical binding]; other site 572264007639 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 572264007640 DinB superfamily; Region: DinB_2; pfam12867 572264007641 Protein of unknown function (DUF664); Region: DUF664; pfam04978 572264007642 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 572264007643 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264007644 Coenzyme A binding pocket [chemical binding]; other site 572264007645 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572264007646 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 572264007647 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 572264007648 active site 572264007649 NTP binding site [chemical binding]; other site 572264007650 metal binding triad [ion binding]; metal-binding site 572264007651 antibiotic binding site [chemical binding]; other site 572264007652 A new structural DNA glycosylase; Region: AlkD_like; cd06561 572264007653 active site 572264007654 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 572264007655 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 572264007656 NodB motif; other site 572264007657 active site 572264007658 catalytic site [active] 572264007659 Zn binding site [ion binding]; other site 572264007660 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 572264007661 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 572264007662 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 572264007663 Sulfatase; Region: Sulfatase; pfam00884 572264007664 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 572264007665 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264007666 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264007667 ABC transporter; Region: ABC_tran_2; pfam12848 572264007668 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264007669 hypothetical protein; Provisional; Region: PRK06761 572264007670 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264007671 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264007672 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 572264007673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264007674 Coenzyme A binding pocket [chemical binding]; other site 572264007675 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 572264007676 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 572264007677 hinge; other site 572264007678 active site 572264007679 prephenate dehydrogenase; Validated; Region: PRK06545 572264007680 prephenate dehydrogenase; Validated; Region: PRK08507 572264007681 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 572264007682 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 572264007683 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572264007684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264007685 homodimer interface [polypeptide binding]; other site 572264007686 catalytic residue [active] 572264007687 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 572264007688 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 572264007689 Tetramer interface [polypeptide binding]; other site 572264007690 active site 572264007691 FMN-binding site [chemical binding]; other site 572264007692 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 572264007693 Chorismate mutase type II; Region: CM_2; cl00693 572264007694 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 572264007695 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 572264007696 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 572264007697 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 572264007698 Isochorismatase family; Region: Isochorismatase; pfam00857 572264007699 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 572264007700 catalytic triad [active] 572264007701 conserved cis-peptide bond; other site 572264007702 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 572264007703 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264007704 Coenzyme A binding pocket [chemical binding]; other site 572264007705 YfzA-like protein; Region: YfzA; pfam14118 572264007706 hypothetical protein; Provisional; Region: PRK06762 572264007707 AAA domain; Region: AAA_33; pfam13671 572264007708 Bacterial SH3 domain; Region: SH3_3; pfam08239 572264007709 Bacterial SH3 domain; Region: SH3_3; pfam08239 572264007710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 572264007711 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572264007712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264007713 Coenzyme A binding pocket [chemical binding]; other site 572264007714 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 572264007715 enoyl-CoA hydratase; Provisional; Region: PRK06688 572264007716 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572264007717 substrate binding site [chemical binding]; other site 572264007718 oxyanion hole (OAH) forming residues; other site 572264007719 trimer interface [polypeptide binding]; other site 572264007720 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 572264007721 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572264007722 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 572264007723 putative AMP binding site [chemical binding]; other site 572264007724 putative active site [active] 572264007725 acyl-activating enzyme (AAE) consensus motif; other site 572264007726 putative CoA binding site [chemical binding]; other site 572264007727 PAS domain; Region: PAS; smart00091 572264007728 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 572264007729 putative active site [active] 572264007730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264007731 Walker A motif; other site 572264007732 ATP binding site [chemical binding]; other site 572264007733 Walker B motif; other site 572264007734 arginine finger; other site 572264007735 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 572264007736 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 572264007737 malate:quinone oxidoreductase; Validated; Region: PRK05257 572264007738 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 572264007739 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 572264007740 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 572264007741 ligand binding site [chemical binding]; other site 572264007742 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 572264007743 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 572264007744 TM-ABC transporter signature motif; other site 572264007745 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 572264007746 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 572264007747 TM-ABC transporter signature motif; other site 572264007748 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 572264007749 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 572264007750 Walker A/P-loop; other site 572264007751 ATP binding site [chemical binding]; other site 572264007752 Q-loop/lid; other site 572264007753 ABC transporter signature motif; other site 572264007754 Walker B; other site 572264007755 D-loop; other site 572264007756 H-loop/switch region; other site 572264007757 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 572264007758 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 572264007759 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 572264007760 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 572264007761 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 572264007762 putative N- and C-terminal domain interface [polypeptide binding]; other site 572264007763 putative active site [active] 572264007764 putative MgATP binding site [chemical binding]; other site 572264007765 catalytic site [active] 572264007766 metal binding site [ion binding]; metal-binding site 572264007767 putative carbohydrate binding site [chemical binding]; other site 572264007768 Cupin domain; Region: Cupin_2; pfam07883 572264007769 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 572264007770 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 572264007771 putative active site; other site 572264007772 catalytic residue [active] 572264007773 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572264007774 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 572264007775 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 572264007776 active site 572264007777 NTP binding site [chemical binding]; other site 572264007778 metal binding triad [ion binding]; metal-binding site 572264007779 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 572264007780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264007781 H+ Antiporter protein; Region: 2A0121; TIGR00900 572264007782 putative substrate translocation pore; other site 572264007783 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264007784 putative DNA binding site [nucleotide binding]; other site 572264007785 putative Zn2+ binding site [ion binding]; other site 572264007786 DinB superfamily; Region: DinB_2; pfam12867 572264007787 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 572264007788 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 572264007789 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 572264007790 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 572264007791 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 572264007792 putative catalytic cysteine [active] 572264007793 gamma-glutamyl kinase; Provisional; Region: PRK05429 572264007794 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 572264007795 nucleotide binding site [chemical binding]; other site 572264007796 homotetrameric interface [polypeptide binding]; other site 572264007797 putative phosphate binding site [ion binding]; other site 572264007798 putative allosteric binding site; other site 572264007799 PUA domain; Region: PUA; pfam01472 572264007800 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 572264007801 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 572264007802 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 572264007803 putative metal binding site [ion binding]; other site 572264007804 putative dimer interface [polypeptide binding]; other site 572264007805 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 572264007806 Transcriptional regulator [Transcription]; Region: IclR; COG1414 572264007807 Bacterial transcriptional regulator; Region: IclR; pfam01614 572264007808 S-methylmethionine transporter; Provisional; Region: PRK11387 572264007809 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 572264007810 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 572264007811 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 572264007812 putative di-iron ligands [ion binding]; other site 572264007813 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 572264007814 dimer interface [polypeptide binding]; other site 572264007815 Alkaline phosphatase homologues; Region: alkPPc; smart00098 572264007816 active site 572264007817 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 572264007818 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264007819 salt bridge; other site 572264007820 non-specific DNA binding site [nucleotide binding]; other site 572264007821 sequence-specific DNA binding site [nucleotide binding]; other site 572264007822 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 572264007823 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 572264007824 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 572264007825 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 572264007826 LytTr DNA-binding domain; Region: LytTR; pfam04397 572264007827 uridine kinase; Provisional; Region: PRK07667 572264007828 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572264007829 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264007830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 572264007831 Coenzyme A binding pocket [chemical binding]; other site 572264007832 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572264007833 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 572264007834 active site 572264007835 metal binding site [ion binding]; metal-binding site 572264007836 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 572264007837 Predicted transcriptional regulators [Transcription]; Region: COG1695 572264007838 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 572264007839 MoxR-like ATPases [General function prediction only]; Region: COG0714 572264007840 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264007841 Walker A motif; other site 572264007842 ATP binding site [chemical binding]; other site 572264007843 Walker B motif; other site 572264007844 arginine finger; other site 572264007845 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 572264007846 Protein of unknown function DUF58; Region: DUF58; pfam01882 572264007847 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 572264007848 proline/glycine betaine transporter; Provisional; Region: PRK10642 572264007849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264007850 putative substrate translocation pore; other site 572264007851 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 572264007852 active site 572264007853 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 572264007854 active site 572264007855 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 572264007856 active site 572264007857 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 572264007858 Ligand binding site; other site 572264007859 Putative Catalytic site; other site 572264007860 DXD motif; other site 572264007861 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 572264007862 active site 572264007863 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 572264007864 Ligand binding site; other site 572264007865 Putative Catalytic site; other site 572264007866 DXD motif; other site 572264007867 acetylornithine aminotransferase; Provisional; Region: PRK02627 572264007868 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 572264007869 inhibitor-cofactor binding pocket; inhibition site 572264007870 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264007871 catalytic residue [active] 572264007872 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 572264007873 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 572264007874 tetramer interface [polypeptide binding]; other site 572264007875 heme binding pocket [chemical binding]; other site 572264007876 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 572264007877 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 572264007878 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 572264007879 active site 572264007880 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 572264007881 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572264007882 Beta-lactamase; Region: Beta-lactamase; pfam00144 572264007883 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 572264007884 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 572264007885 Uncharacterized conserved protein [Function unknown]; Region: COG1359 572264007886 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 572264007887 dimer interface [polypeptide binding]; other site 572264007888 FMN binding site [chemical binding]; other site 572264007889 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 572264007890 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264007891 putative DNA binding site [nucleotide binding]; other site 572264007892 putative Zn2+ binding site [ion binding]; other site 572264007893 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 572264007894 G1 box; other site 572264007895 GTP/Mg2+ binding site [chemical binding]; other site 572264007896 elongation factor G; Reviewed; Region: PRK13351 572264007897 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 572264007898 Switch I region; other site 572264007899 G2 box; other site 572264007900 putative GEF interaction site [polypeptide binding]; other site 572264007901 G3 box; other site 572264007902 Switch II region; other site 572264007903 GTP/Mg2+ binding site [chemical binding]; other site 572264007904 G4 box; other site 572264007905 G5 box; other site 572264007906 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 572264007907 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 572264007908 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 572264007909 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 572264007910 nudix motif; other site 572264007911 YfzA-like protein; Region: YfzA; pfam14118 572264007912 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 572264007913 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 572264007914 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 572264007915 Walker A/P-loop; other site 572264007916 ATP binding site [chemical binding]; other site 572264007917 Q-loop/lid; other site 572264007918 ABC transporter signature motif; other site 572264007919 Walker B; other site 572264007920 D-loop; other site 572264007921 H-loop/switch region; other site 572264007922 Predicted transcriptional regulators [Transcription]; Region: COG1725 572264007923 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572264007924 DNA-binding site [nucleotide binding]; DNA binding site 572264007925 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 572264007926 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 572264007927 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 572264007928 putative NAD(P) binding site [chemical binding]; other site 572264007929 active site 572264007930 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572264007931 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572264007932 Walker A/P-loop; other site 572264007933 ATP binding site [chemical binding]; other site 572264007934 Q-loop/lid; other site 572264007935 ABC transporter signature motif; other site 572264007936 Walker B; other site 572264007937 D-loop; other site 572264007938 H-loop/switch region; other site 572264007939 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 572264007940 FtsX-like permease family; Region: FtsX; pfam02687 572264007941 FtsX-like permease family; Region: FtsX; pfam02687 572264007942 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572264007943 Beta-lactamase; Region: Beta-lactamase; pfam00144 572264007944 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 572264007945 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 572264007946 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 572264007947 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 572264007948 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264007949 Coenzyme A binding pocket [chemical binding]; other site 572264007950 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 572264007951 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 572264007952 nudix motif; other site 572264007953 EamA-like transporter family; Region: EamA; pfam00892 572264007954 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 572264007955 EamA-like transporter family; Region: EamA; pfam00892 572264007956 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 572264007957 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572264007958 DNA-binding site [nucleotide binding]; DNA binding site 572264007959 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572264007960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264007961 homodimer interface [polypeptide binding]; other site 572264007962 catalytic residue [active] 572264007963 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 572264007964 hypothetical protein; Validated; Region: PRK00124 572264007965 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 572264007966 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264007967 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 572264007968 phosphorylation site [posttranslational modification] 572264007969 dimer interface [polypeptide binding]; other site 572264007970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264007971 ATP binding site [chemical binding]; other site 572264007972 Mg2+ binding site [ion binding]; other site 572264007973 G-X-G motif; other site 572264007974 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264007975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264007976 active site 572264007977 phosphorylation site [posttranslational modification] 572264007978 intermolecular recognition site; other site 572264007979 dimerization interface [polypeptide binding]; other site 572264007980 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264007981 DNA binding site [nucleotide binding] 572264007982 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 572264007983 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 572264007984 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 572264007985 uridine kinase; Validated; Region: PRK06696 572264007986 active site 572264007987 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 572264007988 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 572264007989 active site 572264007990 metal binding site [ion binding]; metal-binding site 572264007991 Phosphotransferase enzyme family; Region: APH; pfam01636 572264007992 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 572264007993 active site 572264007994 substrate binding site [chemical binding]; other site 572264007995 ATP binding site [chemical binding]; other site 572264007996 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 572264007997 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 572264007998 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572264007999 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 572264008000 Lysine riboswitch 572264008001 lysine transporter; Provisional; Region: PRK10836 572264008002 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 572264008003 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 572264008004 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 572264008005 DNA binding residues [nucleotide binding] 572264008006 dimer interface [polypeptide binding]; other site 572264008007 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 572264008008 Methyltransferase domain; Region: Methyltransf_11; pfam08241 572264008009 S-adenosylmethionine binding site [chemical binding]; other site 572264008010 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 572264008011 putative active site [active] 572264008012 nucleotide binding site [chemical binding]; other site 572264008013 nudix motif; other site 572264008014 putative metal binding site [ion binding]; other site 572264008015 Cephalosporin hydroxylase; Region: CmcI; pfam04989 572264008016 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 572264008017 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 572264008018 Catalytic site [active] 572264008019 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 572264008020 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 572264008021 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572264008022 NAD-dependent deacetylase; Provisional; Region: PRK00481 572264008023 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 572264008024 NAD+ binding site [chemical binding]; other site 572264008025 substrate binding site [chemical binding]; other site 572264008026 Zn binding site [ion binding]; other site 572264008027 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 572264008028 putative substrate binding pocket [chemical binding]; other site 572264008029 AC domain interface; other site 572264008030 catalytic triad [active] 572264008031 AB domain interface; other site 572264008032 interchain disulfide; other site 572264008033 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 572264008034 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 572264008035 Predicted membrane protein [Function unknown]; Region: COG3817 572264008036 Protein of unknown function (DUF979); Region: DUF979; pfam06166 572264008037 Protein of unknown function (DUF969); Region: DUF969; pfam06149 572264008038 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 572264008039 putative active site [active] 572264008040 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 572264008041 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 572264008042 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 572264008043 Transcriptional regulator [Transcription]; Region: IclR; COG1414 572264008044 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 572264008045 Bacterial transcriptional regulator; Region: IclR; pfam01614 572264008046 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 572264008047 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 572264008048 Catalytic site [active] 572264008049 CutC family; Region: CutC; cl01218 572264008050 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 572264008051 stage II sporulation protein P; Region: spore_II_P; TIGR02867 572264008052 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264008053 dimerization interface [polypeptide binding]; other site 572264008054 putative DNA binding site [nucleotide binding]; other site 572264008055 putative Zn2+ binding site [ion binding]; other site 572264008056 DinB superfamily; Region: DinB_2; pfam12867 572264008057 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572264008058 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572264008059 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 572264008060 Uncharacterized conserved protein [Function unknown]; Region: COG1434 572264008061 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 572264008062 putative active site [active] 572264008063 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 572264008064 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 572264008065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 572264008066 Nucleoside recognition; Region: Gate; pfam07670 572264008067 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 572264008068 Phosphotransferase enzyme family; Region: APH; pfam01636 572264008069 putative active site [active] 572264008070 putative substrate binding site [chemical binding]; other site 572264008071 ATP binding site [chemical binding]; other site 572264008072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264008073 Coenzyme A binding pocket [chemical binding]; other site 572264008074 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 572264008075 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 572264008076 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264008077 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264008078 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 572264008079 phosphoenolpyruvate synthase; Validated; Region: PRK06241 572264008080 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 572264008081 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 572264008082 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572264008083 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 572264008084 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 572264008085 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 572264008086 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 572264008087 LysE type translocator; Region: LysE; pfam01810 572264008088 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 572264008089 Spore germination protein; Region: Spore_permease; cl17796 572264008090 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 572264008091 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 572264008092 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 572264008093 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 572264008094 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 572264008095 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 572264008096 NAD binding site [chemical binding]; other site 572264008097 catalytic Zn binding site [ion binding]; other site 572264008098 structural Zn binding site [ion binding]; other site 572264008099 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 572264008100 dimanganese center [ion binding]; other site 572264008101 YolD-like protein; Region: YolD; pfam08863 572264008102 DNA polymerase IV; Reviewed; Region: PRK03103 572264008103 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 572264008104 active site 572264008105 DNA binding site [nucleotide binding] 572264008106 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 572264008107 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572264008108 Beta-lactamase; Region: Beta-lactamase; pfam00144 572264008109 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 572264008110 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 572264008111 putative active site [active] 572264008112 putative metal binding site [ion binding]; other site 572264008113 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 572264008114 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 572264008115 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 572264008116 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 572264008117 Cl binding site [ion binding]; other site 572264008118 oligomer interface [polypeptide binding]; other site 572264008119 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 572264008120 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 572264008121 Mg binding site [ion binding]; other site 572264008122 nucleotide binding site [chemical binding]; other site 572264008123 putative protofilament interface [polypeptide binding]; other site 572264008124 Heat induced stress protein YflT; Region: YflT; pfam11181 572264008125 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 572264008126 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 572264008127 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 572264008128 putative NAD(P) binding site [chemical binding]; other site 572264008129 catalytic Zn binding site [ion binding]; other site 572264008130 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 572264008131 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264008132 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 572264008133 Cytochrome P450; Region: p450; cl12078 572264008134 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264008135 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264008136 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 572264008137 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 572264008138 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 572264008139 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 572264008140 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 572264008141 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 572264008142 TspO/MBR family; Region: TspO_MBR; pfam03073 572264008143 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 572264008144 DNA photolyase; Region: DNA_photolyase; pfam00875 572264008145 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 572264008146 zinc binding site [ion binding]; other site 572264008147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 572264008148 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 572264008149 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 572264008150 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 572264008151 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 572264008152 Protein of unknown function DUF58; Region: DUF58; pfam01882 572264008153 MoxR-like ATPases [General function prediction only]; Region: COG0714 572264008154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264008155 Walker A motif; other site 572264008156 ATP binding site [chemical binding]; other site 572264008157 Walker B motif; other site 572264008158 arginine finger; other site 572264008159 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 572264008160 UbiA prenyltransferase family; Region: UbiA; pfam01040 572264008161 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572264008162 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 572264008163 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 572264008164 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 572264008165 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572264008166 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572264008167 Walker A/P-loop; other site 572264008168 ATP binding site [chemical binding]; other site 572264008169 Q-loop/lid; other site 572264008170 ABC transporter signature motif; other site 572264008171 Walker B; other site 572264008172 D-loop; other site 572264008173 H-loop/switch region; other site 572264008174 FtsX-like permease family; Region: FtsX; pfam02687 572264008175 FtsX-like permease family; Region: FtsX; pfam02687 572264008176 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 572264008177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264008178 ATP binding site [chemical binding]; other site 572264008179 Mg2+ binding site [ion binding]; other site 572264008180 G-X-G motif; other site 572264008181 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 572264008182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264008183 active site 572264008184 phosphorylation site [posttranslational modification] 572264008185 intermolecular recognition site; other site 572264008186 dimerization interface [polypeptide binding]; other site 572264008187 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572264008188 DNA binding residues [nucleotide binding] 572264008189 dimerization interface [polypeptide binding]; other site 572264008190 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 572264008191 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 572264008192 metal binding site [ion binding]; metal-binding site 572264008193 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 572264008194 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572264008195 ABC-ATPase subunit interface; other site 572264008196 dimer interface [polypeptide binding]; other site 572264008197 putative PBP binding regions; other site 572264008198 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 572264008199 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 572264008200 DJ-1 family protein; Region: not_thiJ; TIGR01383 572264008201 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 572264008202 conserved cys residue [active] 572264008203 Phosphotransferase enzyme family; Region: APH; pfam01636 572264008204 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 572264008205 active site 572264008206 ATP binding site [chemical binding]; other site 572264008207 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 572264008208 active site 572264008209 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 572264008210 Low molecular weight phosphatase family; Region: LMWPc; cd00115 572264008211 active site 572264008212 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 572264008213 arsenical-resistance protein; Region: acr3; TIGR00832 572264008214 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572264008215 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 572264008216 putative metal binding site [ion binding]; other site 572264008217 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264008218 dimerization interface [polypeptide binding]; other site 572264008219 putative DNA binding site [nucleotide binding]; other site 572264008220 putative Zn2+ binding site [ion binding]; other site 572264008221 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 572264008222 DnaJ domain; Region: DnaJ; pfam00226 572264008223 HSP70 interaction site [polypeptide binding]; other site 572264008224 TPR repeat; Region: TPR_11; pfam13414 572264008225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264008226 binding surface 572264008227 TPR motif; other site 572264008228 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 572264008229 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 572264008230 nucleotide binding site [chemical binding]; other site 572264008231 putative NEF/HSP70 interaction site [polypeptide binding]; other site 572264008232 SBD interface [polypeptide binding]; other site 572264008233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264008234 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264008235 putative substrate translocation pore; other site 572264008236 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 572264008237 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 572264008238 metal binding site [ion binding]; metal-binding site 572264008239 AAA domain; Region: AAA_11; pfam13086 572264008240 Part of AAA domain; Region: AAA_19; pfam13245 572264008241 Erp protein C-terminus; Region: Erp_C; pfam06780 572264008242 AAA domain; Region: AAA_30; pfam13604 572264008243 AAA domain; Region: AAA_12; pfam13087 572264008244 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 572264008245 putative active site [active] 572264008246 catalytic site [active] 572264008247 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572264008248 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 572264008249 active site 572264008250 metal binding site [ion binding]; metal-binding site 572264008251 Beta-lactamase; Region: Beta-lactamase; pfam00144 572264008252 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572264008253 hypothetical protein; Provisional; Region: PRK06770 572264008254 putative monooxygenase; Provisional; Region: PRK11118 572264008255 DoxX-like family; Region: DoxX_2; pfam13564 572264008256 Transcriptional regulators [Transcription]; Region: MarR; COG1846 572264008257 MarR family; Region: MarR_2; pfam12802 572264008258 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 572264008259 Cytochrome P450; Region: p450; pfam00067 572264008260 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 572264008261 Flavodoxin; Region: Flavodoxin_1; pfam00258 572264008262 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 572264008263 FAD binding pocket [chemical binding]; other site 572264008264 FAD binding motif [chemical binding]; other site 572264008265 catalytic residues [active] 572264008266 NAD binding pocket [chemical binding]; other site 572264008267 phosphate binding motif [ion binding]; other site 572264008268 beta-alpha-beta structure motif; other site 572264008269 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 572264008270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264008271 putative substrate translocation pore; other site 572264008272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264008273 Malarial early transcribed membrane protein (ETRAMP); Region: ETRAMP; cl09917 572264008274 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 572264008275 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264008276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264008277 active site 572264008278 phosphorylation site [posttranslational modification] 572264008279 intermolecular recognition site; other site 572264008280 dimerization interface [polypeptide binding]; other site 572264008281 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264008282 DNA binding site [nucleotide binding] 572264008283 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264008284 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264008285 dimerization interface [polypeptide binding]; other site 572264008286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264008287 dimer interface [polypeptide binding]; other site 572264008288 phosphorylation site [posttranslational modification] 572264008289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264008290 ATP binding site [chemical binding]; other site 572264008291 G-X-G motif; other site 572264008292 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 572264008293 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 572264008294 D-cysteine desulfhydrase; Validated; Region: PRK03910 572264008295 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 572264008296 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572264008297 catalytic residue [active] 572264008298 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 572264008299 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 572264008300 active site 572264008301 metal binding site [ion binding]; metal-binding site 572264008302 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 572264008303 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572264008304 Beta-lactamase; Region: Beta-lactamase; pfam00144 572264008305 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 572264008306 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 572264008307 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 572264008308 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 572264008309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572264008310 NAD(P) binding site [chemical binding]; other site 572264008311 active site 572264008312 hypothetical protein; Provisional; Region: PRK06849 572264008313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572264008314 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 572264008315 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 572264008316 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 572264008317 dimer interface [polypeptide binding]; other site 572264008318 active site 572264008319 CoA binding pocket [chemical binding]; other site 572264008320 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 572264008321 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 572264008322 CAAX protease self-immunity; Region: Abi; pfam02517 572264008323 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 572264008324 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 572264008325 DNA binding residues [nucleotide binding] 572264008326 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 572264008327 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 572264008328 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 572264008329 trimer interface [polypeptide binding]; other site 572264008330 active site 572264008331 SEC-C motif; Region: SEC-C; pfam02810 572264008332 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 572264008333 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572264008334 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572264008335 Walker A/P-loop; other site 572264008336 ATP binding site [chemical binding]; other site 572264008337 Q-loop/lid; other site 572264008338 ABC transporter signature motif; other site 572264008339 Walker B; other site 572264008340 D-loop; other site 572264008341 H-loop/switch region; other site 572264008342 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 572264008343 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 572264008344 FtsX-like permease family; Region: FtsX; pfam02687 572264008345 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264008346 dimerization interface [polypeptide binding]; other site 572264008347 putative DNA binding site [nucleotide binding]; other site 572264008348 Predicted transcriptional regulator [Transcription]; Region: COG2345 572264008349 putative Zn2+ binding site [ion binding]; other site 572264008350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264008351 H+ Antiporter protein; Region: 2A0121; TIGR00900 572264008352 putative substrate translocation pore; other site 572264008353 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 572264008354 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264008355 dimerization interface [polypeptide binding]; other site 572264008356 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264008357 dimer interface [polypeptide binding]; other site 572264008358 phosphorylation site [posttranslational modification] 572264008359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264008360 ATP binding site [chemical binding]; other site 572264008361 Mg2+ binding site [ion binding]; other site 572264008362 G-X-G motif; other site 572264008363 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264008364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264008365 active site 572264008366 phosphorylation site [posttranslational modification] 572264008367 intermolecular recognition site; other site 572264008368 dimerization interface [polypeptide binding]; other site 572264008369 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264008370 DNA binding site [nucleotide binding] 572264008371 Predicted membrane protein [Function unknown]; Region: COG2364 572264008372 Transcriptional regulators [Transcription]; Region: MarR; COG1846 572264008373 MarR family; Region: MarR; pfam01047 572264008374 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 572264008375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264008376 Coenzyme A binding pocket [chemical binding]; other site 572264008377 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 572264008378 Uncharacterized conserved protein [Function unknown]; Region: COG1284 572264008379 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 572264008380 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 572264008381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264008382 D-galactonate transporter; Region: 2A0114; TIGR00893 572264008383 putative substrate translocation pore; other site 572264008384 Uncharacterized conserved protein [Function unknown]; Region: COG1556 572264008385 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 572264008386 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 572264008387 4Fe-4S binding domain; Region: Fer4; pfam00037 572264008388 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 572264008389 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 572264008390 Cysteine-rich domain; Region: CCG; pfam02754 572264008391 Cysteine-rich domain; Region: CCG; pfam02754 572264008392 Transcriptional regulator [Transcription]; Region: LysR; COG0583 572264008393 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572264008394 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 572264008395 dimerization interface [polypeptide binding]; other site 572264008396 2TM domain; Region: 2TM; pfam13239 572264008397 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 572264008398 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 572264008399 putative dimer interface [polypeptide binding]; other site 572264008400 catalytic triad [active] 572264008401 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 572264008402 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 572264008403 active site residue [active] 572264008404 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 572264008405 active site residue [active] 572264008406 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 572264008407 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572264008408 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 572264008409 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 572264008410 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 572264008411 active site 572264008412 Zn binding site [ion binding]; other site 572264008413 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613 572264008414 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 572264008415 putative active site [active] 572264008416 catalytic site [active] 572264008417 putative metal binding site [ion binding]; other site 572264008418 VanZ like family; Region: VanZ; pfam04892 572264008419 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264008420 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264008421 dimer interface [polypeptide binding]; other site 572264008422 phosphorylation site [posttranslational modification] 572264008423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264008424 ATP binding site [chemical binding]; other site 572264008425 Mg2+ binding site [ion binding]; other site 572264008426 G-X-G motif; other site 572264008427 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264008428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264008429 active site 572264008430 phosphorylation site [posttranslational modification] 572264008431 intermolecular recognition site; other site 572264008432 dimerization interface [polypeptide binding]; other site 572264008433 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264008434 DNA binding site [nucleotide binding] 572264008435 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572264008436 Beta-lactamase; Region: Beta-lactamase; pfam00144 572264008437 S-layer homology domain; Region: SLH; pfam00395 572264008438 S-layer homology domain; Region: SLH; pfam00395 572264008439 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 572264008440 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 572264008441 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 572264008442 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 572264008443 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 572264008444 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 572264008445 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 572264008446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264008447 putative substrate translocation pore; other site 572264008448 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 572264008449 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 572264008450 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 572264008451 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 572264008452 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264008453 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 572264008454 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 572264008455 inhibitor-cofactor binding pocket; inhibition site 572264008456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264008457 catalytic residue [active] 572264008458 Transcriptional regulators [Transcription]; Region: PurR; COG1609 572264008459 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 572264008460 DNA binding site [nucleotide binding] 572264008461 domain linker motif; other site 572264008462 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 572264008463 putative dimerization interface [polypeptide binding]; other site 572264008464 putative ligand binding site [chemical binding]; other site 572264008465 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 572264008466 TPR motif; other site 572264008467 Tetratricopeptide repeat; Region: TPR_12; pfam13424 572264008468 binding surface 572264008469 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264008470 TPR motif; other site 572264008471 binding surface 572264008472 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257 572264008473 PKC phosphorylation site [posttranslational modification]; other site 572264008474 DNA polymerase IV; Reviewed; Region: PRK03103 572264008475 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 572264008476 active site 572264008477 DNA binding site [nucleotide binding] 572264008478 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 572264008479 YolD-like protein; Region: YolD; pfam08863 572264008480 Tar ligand binding domain homologue; Region: TarH; pfam02203 572264008481 Cache domain; Region: Cache_1; pfam02743 572264008482 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264008483 dimerization interface [polypeptide binding]; other site 572264008484 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572264008485 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572264008486 dimer interface [polypeptide binding]; other site 572264008487 putative CheW interface [polypeptide binding]; other site 572264008488 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 572264008489 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 572264008490 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 572264008491 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 572264008492 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 572264008493 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 572264008494 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 572264008495 inhibitor-cofactor binding pocket; inhibition site 572264008496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264008497 catalytic residue [active] 572264008498 Acylphosphatase; Region: Acylphosphatase; pfam00708 572264008499 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 572264008500 HypF finger; Region: zf-HYPF; pfam07503 572264008501 HypF finger; Region: zf-HYPF; pfam07503 572264008502 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 572264008503 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 572264008504 dimerization interface [polypeptide binding]; other site 572264008505 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 572264008506 ATP binding site [chemical binding]; other site 572264008507 Isochorismatase family; Region: Isochorismatase; pfam00857 572264008508 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 572264008509 catalytic triad [active] 572264008510 conserved cis-peptide bond; other site 572264008511 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 572264008512 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264008513 putative DNA binding site [nucleotide binding]; other site 572264008514 putative Zn2+ binding site [ion binding]; other site 572264008515 AsnC family; Region: AsnC_trans_reg; pfam01037 572264008516 putative transporter; Provisional; Region: PRK11021 572264008517 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 572264008518 Uncharacterized conserved protein [Function unknown]; Region: COG4198 572264008519 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 572264008520 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 572264008521 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 572264008522 putative ligand binding site [chemical binding]; other site 572264008523 putative NAD binding site [chemical binding]; other site 572264008524 putative catalytic site [active] 572264008525 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 572264008526 L-serine binding site [chemical binding]; other site 572264008527 ACT domain interface; other site 572264008528 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 572264008529 homodimer interface [polypeptide binding]; other site 572264008530 substrate-cofactor binding pocket; other site 572264008531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264008532 catalytic residue [active] 572264008533 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 572264008534 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 572264008535 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 572264008536 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264008537 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 572264008538 DNA binding residues [nucleotide binding] 572264008539 Uncharacterized conserved protein [Function unknown]; Region: COG2155 572264008540 Cupin domain; Region: Cupin_2; cl17218 572264008541 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 572264008542 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 572264008543 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 572264008544 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 572264008545 Proteins of 100 residues with WXG; Region: WXG100; cl02005 572264008546 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 572264008547 Penicillin amidase; Region: Penicil_amidase; pfam01804 572264008548 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 572264008549 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 572264008550 active site 572264008551 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 572264008552 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 572264008553 amidase catalytic site [active] 572264008554 Zn binding residues [ion binding]; other site 572264008555 substrate binding site [chemical binding]; other site 572264008556 Bacterial SH3 domain; Region: SH3_3; pfam08239 572264008557 S-layer homology domain; Region: SLH; pfam00395 572264008558 S-layer homology domain; Region: SLH; pfam00395 572264008559 S-layer homology domain; Region: SLH; pfam00395 572264008560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264008561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264008562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264008563 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264008564 putative substrate translocation pore; other site 572264008565 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 572264008566 A new structural DNA glycosylase; Region: AlkD_like; cd06561 572264008567 active site 572264008568 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 572264008569 S-layer homology domain; Region: SLH; pfam00395 572264008570 S-layer homology domain; Region: SLH; pfam00395 572264008571 S-layer homology domain; Region: SLH; pfam00395 572264008572 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 572264008573 putative metal binding site [ion binding]; other site 572264008574 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572264008575 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 572264008576 NETI protein; Region: NETI; pfam14044 572264008577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264008578 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264008579 putative substrate translocation pore; other site 572264008580 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572264008581 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 572264008582 TAP-like protein; Region: Abhydrolase_4; pfam08386 572264008583 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 572264008584 MarR family; Region: MarR_2; pfam12802 572264008585 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264008586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264008587 putative substrate translocation pore; other site 572264008588 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572264008589 Beta-lactamase; Region: Beta-lactamase; pfam00144 572264008590 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 572264008591 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 572264008592 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 572264008593 Walker A/P-loop; other site 572264008594 ATP binding site [chemical binding]; other site 572264008595 Q-loop/lid; other site 572264008596 ABC transporter signature motif; other site 572264008597 Walker B; other site 572264008598 D-loop; other site 572264008599 H-loop/switch region; other site 572264008600 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 572264008601 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264008602 putative DNA binding site [nucleotide binding]; other site 572264008603 putative Zn2+ binding site [ion binding]; other site 572264008604 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 572264008605 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264008606 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264008607 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 572264008608 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 572264008609 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 572264008610 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 572264008611 SWIM zinc finger; Region: SWIM; pfam04434 572264008612 YwiC-like protein; Region: YwiC; pfam14256 572264008613 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 572264008614 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 572264008615 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 572264008616 Walker A/P-loop; other site 572264008617 ATP binding site [chemical binding]; other site 572264008618 Q-loop/lid; other site 572264008619 ABC transporter signature motif; other site 572264008620 Walker B; other site 572264008621 D-loop; other site 572264008622 H-loop/switch region; other site 572264008623 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 572264008624 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 572264008625 Walker A/P-loop; other site 572264008626 ATP binding site [chemical binding]; other site 572264008627 Q-loop/lid; other site 572264008628 ABC transporter signature motif; other site 572264008629 Walker B; other site 572264008630 D-loop; other site 572264008631 H-loop/switch region; other site 572264008632 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 572264008633 Calreticulin family; Region: Calreticulin; pfam00262 572264008634 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 572264008635 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 572264008636 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 572264008637 Predicted membrane protein [Function unknown]; Region: COG1288 572264008638 Endonuclease I; Region: Endonuclease_1; pfam04231 572264008639 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 572264008640 putative deacylase active site [active] 572264008641 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572264008642 Beta-lactamase; Region: Beta-lactamase; pfam00144 572264008643 Beta-lactamase; Region: Beta-lactamase; pfam00144 572264008644 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572264008645 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 572264008646 Histidine kinase; Region: HisKA_3; pfam07730 572264008647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264008648 ATP binding site [chemical binding]; other site 572264008649 Mg2+ binding site [ion binding]; other site 572264008650 G-X-G motif; other site 572264008651 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 572264008652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264008653 active site 572264008654 phosphorylation site [posttranslational modification] 572264008655 intermolecular recognition site; other site 572264008656 dimerization interface [polypeptide binding]; other site 572264008657 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572264008658 DNA binding residues [nucleotide binding] 572264008659 dimerization interface [polypeptide binding]; other site 572264008660 histidyl-tRNA synthetase; Provisional; Region: PRK12420 572264008661 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 572264008662 dimer interface [polypeptide binding]; other site 572264008663 motif 1; other site 572264008664 active site 572264008665 motif 2; other site 572264008666 motif 3; other site 572264008667 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 572264008668 anticodon binding site; other site 572264008669 Predicted transcriptional regulators [Transcription]; Region: COG1733 572264008670 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 572264008671 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 572264008672 dimer interface [polypeptide binding]; other site 572264008673 FMN binding site [chemical binding]; other site 572264008674 pyruvate kinase; Validated; Region: PRK06739 572264008675 active site 572264008676 domain interfaces; other site 572264008677 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 572264008678 classical (c) SDRs; Region: SDR_c; cd05233 572264008679 NAD(P) binding site [chemical binding]; other site 572264008680 active site 572264008681 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 572264008682 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 572264008683 Walker A/P-loop; other site 572264008684 ATP binding site [chemical binding]; other site 572264008685 Q-loop/lid; other site 572264008686 ABC transporter signature motif; other site 572264008687 Walker B; other site 572264008688 D-loop; other site 572264008689 H-loop/switch region; other site 572264008690 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 572264008691 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264008692 non-specific DNA binding site [nucleotide binding]; other site 572264008693 salt bridge; other site 572264008694 sequence-specific DNA binding site [nucleotide binding]; other site 572264008695 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 572264008696 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264008697 motif II; other site 572264008698 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 572264008699 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 572264008700 Probable transposase; Region: OrfB_IS605; pfam01385 572264008701 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 572264008702 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 572264008703 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 572264008704 catalytic residues [active] 572264008705 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 572264008706 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 572264008707 DNA binding residues [nucleotide binding] 572264008708 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 572264008709 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 572264008710 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 572264008711 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 572264008712 Coenzyme A binding pocket [chemical binding]; other site 572264008713 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 572264008714 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 572264008715 nudix motif; other site 572264008716 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 572264008717 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572264008718 putative metal binding site [ion binding]; other site 572264008719 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 572264008720 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 572264008721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 572264008722 putative substrate translocation pore; other site 572264008723 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264008724 maltose O-acetyltransferase; Provisional; Region: PRK10092 572264008725 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 572264008726 active site 572264008727 substrate binding site [chemical binding]; other site 572264008728 trimer interface [polypeptide binding]; other site 572264008729 CoA binding site [chemical binding]; other site 572264008730 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 572264008731 FtsX-like permease family; Region: FtsX; pfam02687 572264008732 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 572264008733 FtsX-like permease family; Region: FtsX; pfam02687 572264008734 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572264008735 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572264008736 Walker A/P-loop; other site 572264008737 ATP binding site [chemical binding]; other site 572264008738 Q-loop/lid; other site 572264008739 ABC transporter signature motif; other site 572264008740 Walker B; other site 572264008741 D-loop; other site 572264008742 H-loop/switch region; other site 572264008743 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 572264008744 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 572264008745 active site 572264008746 HIGH motif; other site 572264008747 dimer interface [polypeptide binding]; other site 572264008748 KMSKS motif; other site 572264008749 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 572264008750 Domain of unknown function DUF20; Region: UPF0118; pfam01594 572264008751 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264008752 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 572264008753 Coenzyme A binding pocket [chemical binding]; other site 572264008754 ydaO/yuaA leader 572264008755 Methyltransferase domain; Region: Methyltransf_31; pfam13847 572264008756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264008757 S-adenosylmethionine binding site [chemical binding]; other site 572264008758 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 572264008759 CGNR zinc finger; Region: zf-CGNR; pfam11706 572264008760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264008761 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264008762 putative substrate translocation pore; other site 572264008763 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264008764 binding surface 572264008765 TPR motif; other site 572264008766 TPR repeat; Region: TPR_11; pfam13414 572264008767 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264008768 binding surface 572264008769 Tetratricopeptide repeat; Region: TPR_16; pfam13432 572264008770 TPR motif; other site 572264008771 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 572264008772 hypothetical protein; Provisional; Region: PRK04164 572264008773 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 572264008774 ATP synthase I chain; Region: ATP_synt_I; cl09170 572264008775 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 572264008776 Domain of unknown function DUF21; Region: DUF21; pfam01595 572264008777 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 572264008778 Transporter associated domain; Region: CorC_HlyC; smart01091 572264008779 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 572264008780 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 572264008781 DNA binding residues [nucleotide binding] 572264008782 putative dimer interface [polypeptide binding]; other site 572264008783 EamA-like transporter family; Region: EamA; pfam00892 572264008784 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 572264008785 EamA-like transporter family; Region: EamA; pfam00892 572264008786 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 572264008787 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 572264008788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 572264008789 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 572264008790 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 572264008791 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 572264008792 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 572264008793 N- and C-terminal domain interface [polypeptide binding]; other site 572264008794 active site 572264008795 catalytic site [active] 572264008796 metal binding site [ion binding]; metal-binding site 572264008797 carbohydrate binding site [chemical binding]; other site 572264008798 ATP binding site [chemical binding]; other site 572264008799 GntP family permease; Region: GntP_permease; pfam02447 572264008800 fructuronate transporter; Provisional; Region: PRK10034; cl15264 572264008801 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 572264008802 active site 572264008803 intersubunit interactions; other site 572264008804 catalytic residue [active] 572264008805 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 572264008806 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 572264008807 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 572264008808 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 572264008809 TPP-binding site [chemical binding]; other site 572264008810 dimer interface [polypeptide binding]; other site 572264008811 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 572264008812 PYR/PP interface [polypeptide binding]; other site 572264008813 dimer interface [polypeptide binding]; other site 572264008814 TPP binding site [chemical binding]; other site 572264008815 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 572264008816 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 572264008817 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 572264008818 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 572264008819 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 572264008820 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 572264008821 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 572264008822 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 572264008823 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 572264008824 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 572264008825 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 572264008826 hypothetical protein; Provisional; Region: PRK02487 572264008827 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 572264008828 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 572264008829 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 572264008830 IDEAL domain; Region: IDEAL; pfam08858 572264008831 Transcriptional regulator; Region: Rrf2; pfam02082 572264008832 Rrf2 family protein; Region: rrf2_super; TIGR00738 572264008833 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 572264008834 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 572264008835 ArsC family; Region: ArsC; pfam03960 572264008836 putative catalytic residues [active] 572264008837 thiol/disulfide switch; other site 572264008838 Predicted transcriptional regulators [Transcription]; Region: COG1733 572264008839 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 572264008840 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 572264008841 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572264008842 DNA-binding site [nucleotide binding]; DNA binding site 572264008843 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 572264008844 putative oxidoreductase; Provisional; Region: PRK10206 572264008845 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 572264008846 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 572264008847 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 572264008848 putative hydrophobic ligand binding site [chemical binding]; other site 572264008849 protein interface [polypeptide binding]; other site 572264008850 gate; other site 572264008851 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 572264008852 catalytic triad [active] 572264008853 oxyanion hole [active] 572264008854 active site 572264008855 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572264008856 Phosphotransferase enzyme family; Region: APH; pfam01636 572264008857 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 572264008858 substrate binding site [chemical binding]; other site 572264008859 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 572264008860 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 572264008861 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 572264008862 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264008863 Coenzyme A binding pocket [chemical binding]; other site 572264008864 C factor cell-cell signaling protein; Provisional; Region: PRK09009 572264008865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572264008866 NAD(P) binding site [chemical binding]; other site 572264008867 active site 572264008868 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 572264008869 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 572264008870 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572264008871 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 572264008872 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 572264008873 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572264008874 acyl-activating enzyme (AAE) consensus motif; other site 572264008875 AMP binding site [chemical binding]; other site 572264008876 active site 572264008877 CoA binding site [chemical binding]; other site 572264008878 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 572264008879 Predicted transcriptional regulators [Transcription]; Region: COG1733 572264008880 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264008881 dimerization interface [polypeptide binding]; other site 572264008882 putative DNA binding site [nucleotide binding]; other site 572264008883 putative Zn2+ binding site [ion binding]; other site 572264008884 CrcB-like protein; Region: CRCB; cl09114 572264008885 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 572264008886 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 572264008887 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 572264008888 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 572264008889 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 572264008890 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264008891 dimerization interface [polypeptide binding]; other site 572264008892 putative DNA binding site [nucleotide binding]; other site 572264008893 putative Zn2+ binding site [ion binding]; other site 572264008894 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 572264008895 active site 572264008896 Glyco_18 domain; Region: Glyco_18; smart00636 572264008897 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 572264008898 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 572264008899 NodB motif; other site 572264008900 putative active site [active] 572264008901 putative catalytic site [active] 572264008902 putative Zn binding site [ion binding]; other site 572264008903 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 572264008904 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 572264008905 DXD motif; other site 572264008906 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 572264008907 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 572264008908 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264008909 CAAX protease self-immunity; Region: Abi; pfam02517 572264008910 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264008911 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264008912 Protein of unknown function (DUF3963); Region: DUF3963; pfam13124 572264008913 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 572264008914 Predicted transcriptional regulator [Transcription]; Region: COG2378 572264008915 HTH domain; Region: HTH_11; pfam08279 572264008916 WYL domain; Region: WYL; pfam13280 572264008917 Protein of unknown function (DUF805); Region: DUF805; pfam05656 572264008918 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 572264008919 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 572264008920 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 572264008921 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 572264008922 ABC-2 type transporter; Region: ABC2_membrane; cl17235 572264008923 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 572264008924 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264008925 Walker A/P-loop; other site 572264008926 ATP binding site [chemical binding]; other site 572264008927 Q-loop/lid; other site 572264008928 ABC transporter signature motif; other site 572264008929 Walker B; other site 572264008930 D-loop; other site 572264008931 H-loop/switch region; other site 572264008932 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 572264008933 Predicted transcriptional regulators [Transcription]; Region: COG1695 572264008934 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 572264008935 hydroxylamine reductase; Provisional; Region: PRK12310 572264008936 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 572264008937 ACS interaction site; other site 572264008938 CODH interaction site; other site 572264008939 metal cluster binding site [ion binding]; other site 572264008940 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 572264008941 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572264008942 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 572264008943 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 572264008944 active site 572264008945 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 572264008946 metal binding site [ion binding]; metal-binding site 572264008947 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 572264008948 hypothetical protein; Provisional; Region: PRK06771 572264008949 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572264008950 Beta-lactamase; Region: Beta-lactamase; pfam00144 572264008951 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 572264008952 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 572264008953 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 572264008954 dimer interface [polypeptide binding]; other site 572264008955 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572264008956 ligand binding site [chemical binding]; other site 572264008957 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 572264008958 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 572264008959 ligand binding site [chemical binding]; other site 572264008960 flexible hinge region; other site 572264008961 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 572264008962 Protein of unknown function, DUF606; Region: DUF606; pfam04657 572264008963 Protein of unknown function, DUF606; Region: DUF606; pfam04657 572264008964 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572264008965 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 572264008966 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 572264008967 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 572264008968 Predicted transcriptional regulators [Transcription]; Region: COG1695 572264008969 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 572264008970 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 572264008971 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 572264008972 putative NAD(P) binding site [chemical binding]; other site 572264008973 dimer interface [polypeptide binding]; other site 572264008974 putative transport protein YifK; Provisional; Region: PRK10746 572264008975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264008976 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 572264008977 putative substrate translocation pore; other site 572264008978 Haemolysin XhlA; Region: XhlA; pfam10779 572264008979 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 572264008980 classical (c) SDRs; Region: SDR_c; cd05233 572264008981 NAD(P) binding site [chemical binding]; other site 572264008982 active site 572264008983 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 572264008984 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 572264008985 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 572264008986 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 572264008987 transmembrane helices; other site 572264008988 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 572264008989 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264008990 Coenzyme A binding pocket [chemical binding]; other site 572264008991 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 572264008992 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 572264008993 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 572264008994 putative ligand binding residues [chemical binding]; other site 572264008995 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 572264008996 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572264008997 ABC-ATPase subunit interface; other site 572264008998 dimer interface [polypeptide binding]; other site 572264008999 putative PBP binding regions; other site 572264009000 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 572264009001 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572264009002 ABC-ATPase subunit interface; other site 572264009003 dimer interface [polypeptide binding]; other site 572264009004 putative PBP binding regions; other site 572264009005 Protein of unknown function (DUF817); Region: DUF817; pfam05675 572264009006 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 572264009007 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 572264009008 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 572264009009 DinB superfamily; Region: DinB_2; pfam12867 572264009010 DinB family; Region: DinB; cl17821 572264009011 Transcriptional regulator [Transcription]; Region: LysR; COG0583 572264009012 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572264009013 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 572264009014 dimerization interface [polypeptide binding]; other site 572264009015 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 572264009016 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 572264009017 NADP binding site [chemical binding]; other site 572264009018 dimer interface [polypeptide binding]; other site 572264009019 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572264009020 catalytic core [active] 572264009021 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264009022 Coenzyme A binding pocket [chemical binding]; other site 572264009023 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 572264009024 MutS domain III; Region: MutS_III; pfam05192 572264009025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264009026 Walker A/P-loop; other site 572264009027 ATP binding site [chemical binding]; other site 572264009028 Q-loop/lid; other site 572264009029 ABC transporter signature motif; other site 572264009030 Walker B; other site 572264009031 D-loop; other site 572264009032 H-loop/switch region; other site 572264009033 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 572264009034 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 572264009035 active site 572264009036 Na/Ca binding site [ion binding]; other site 572264009037 catalytic site [active] 572264009038 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 572264009039 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 572264009040 oligoendopeptidase F; Region: pepF; TIGR00181 572264009041 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 572264009042 active site 572264009043 Zn binding site [ion binding]; other site 572264009044 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572264009045 Beta-lactamase; Region: Beta-lactamase; pfam00144 572264009046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264009047 putative substrate translocation pore; other site 572264009048 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264009049 Transcriptional regulator [Transcription]; Region: LysR; COG0583 572264009050 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572264009051 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 572264009052 putative dimerization interface [polypeptide binding]; other site 572264009053 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 572264009054 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 572264009055 putative active site [active] 572264009056 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 572264009057 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 572264009058 active site 572264009059 catalytic site [active] 572264009060 metal binding site [ion binding]; metal-binding site 572264009061 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 572264009062 FAD binding domain; Region: FAD_binding_3; pfam01494 572264009063 hypothetical protein; Provisional; Region: PRK07236 572264009064 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264009065 dimerization interface [polypeptide binding]; other site 572264009066 putative DNA binding site [nucleotide binding]; other site 572264009067 putative Zn2+ binding site [ion binding]; other site 572264009068 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 572264009069 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 572264009070 putative NAD(P) binding site [chemical binding]; other site 572264009071 Uncharacterized conserved protein [Function unknown]; Region: COG0397 572264009072 hypothetical protein; Validated; Region: PRK00029 572264009073 Tetratricopeptide repeat; Region: TPR_12; pfam13424 572264009074 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264009075 TPR motif; other site 572264009076 binding surface 572264009077 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 572264009078 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 572264009079 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 572264009080 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 572264009081 Sodium Bile acid symporter family; Region: SBF; cl17470 572264009082 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 572264009083 FAD binding domain; Region: FAD_binding_4; pfam01565 572264009084 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 572264009085 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572264009086 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 572264009087 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 572264009088 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 572264009089 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 572264009090 trimer interface [polypeptide binding]; other site 572264009091 active site 572264009092 substrate binding site [chemical binding]; other site 572264009093 CoA binding site [chemical binding]; other site 572264009094 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 572264009095 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 572264009096 inhibitor-cofactor binding pocket; inhibition site 572264009097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264009098 catalytic residue [active] 572264009099 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 572264009100 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 572264009101 active site 572264009102 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 572264009103 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 572264009104 active site 572264009105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264009106 Methyltransferase domain; Region: Methyltransf_23; pfam13489 572264009107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 572264009108 enoyl-CoA hydratase; Provisional; Region: PRK06688 572264009109 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572264009110 substrate binding site [chemical binding]; other site 572264009111 oxyanion hole (OAH) forming residues; other site 572264009112 trimer interface [polypeptide binding]; other site 572264009113 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 572264009114 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 572264009115 FOG: PKD repeat [General function prediction only]; Region: COG3291 572264009116 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 572264009117 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 572264009118 MgtC family; Region: MgtC; pfam02308 572264009119 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572264009120 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264009121 Coenzyme A binding pocket [chemical binding]; other site 572264009122 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 572264009123 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 572264009124 putative metal binding site [ion binding]; other site 572264009125 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 572264009126 active site 572264009127 metal binding site [ion binding]; metal-binding site 572264009128 VanW like protein; Region: VanW; pfam04294 572264009129 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 572264009130 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 572264009131 exonuclease; Provisional; Region: PRK06722 572264009132 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 572264009133 active site 572264009134 catalytic site [active] 572264009135 substrate binding site [chemical binding]; other site 572264009136 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 572264009137 DNA-binding site [nucleotide binding]; DNA binding site 572264009138 RNA-binding motif; other site 572264009139 flavodoxin; Provisional; Region: PRK06703 572264009140 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 572264009141 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 572264009142 nudix motif; other site 572264009143 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 572264009144 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 572264009145 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 572264009146 trimer interface [polypeptide binding]; other site 572264009147 active site 572264009148 substrate binding site [chemical binding]; other site 572264009149 CoA binding site [chemical binding]; other site 572264009150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 572264009151 Helix-turn-helix domain; Region: HTH_28; pfam13518 572264009152 HTH-like domain; Region: HTH_21; pfam13276 572264009153 Integrase core domain; Region: rve_3; cl15866 572264009154 Haemolysin XhlA; Region: XhlA; pfam10779 572264009155 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 572264009156 Peptidase family M23; Region: Peptidase_M23; pfam01551 572264009157 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 572264009158 N-acetyl-D-glucosamine binding site [chemical binding]; other site 572264009159 catalytic residue [active] 572264009160 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 572264009161 active site 572264009162 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 572264009163 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 572264009164 N-acetyl-D-glucosamine binding site [chemical binding]; other site 572264009165 catalytic residue [active] 572264009166 Helix-turn-helix domain; Region: HTH_36; pfam13730 572264009167 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 572264009168 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264009169 sequence-specific DNA binding site [nucleotide binding]; other site 572264009170 salt bridge; other site 572264009171 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572264009172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264009173 non-specific DNA binding site [nucleotide binding]; other site 572264009174 salt bridge; other site 572264009175 sequence-specific DNA binding site [nucleotide binding]; other site 572264009176 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 572264009177 Domain of unknown function (DUF955); Region: DUF955; cl01076 572264009178 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009179 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009180 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009181 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009182 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009183 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009184 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009185 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009186 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009187 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009188 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009189 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009190 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009191 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009192 short chain dehydrogenase; Provisional; Region: PRK06924 572264009193 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 572264009194 NADP binding site [chemical binding]; other site 572264009195 homodimer interface [polypeptide binding]; other site 572264009196 active site 572264009197 Predicted acetyltransferase [General function prediction only]; Region: COG3393 572264009198 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 572264009199 argininosuccinate lyase; Provisional; Region: PRK06705 572264009200 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 572264009201 active sites [active] 572264009202 tetramer interface [polypeptide binding]; other site 572264009203 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 572264009204 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 572264009205 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 572264009206 active site 572264009207 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 572264009208 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 572264009209 Na binding site [ion binding]; other site 572264009210 Protein of unknown function (DUF997); Region: DUF997; pfam06196 572264009211 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 572264009212 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 572264009213 NAD(P) binding site [chemical binding]; other site 572264009214 catalytic residues [active] 572264009215 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 572264009216 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 572264009217 NAD(P) binding site [chemical binding]; other site 572264009218 homotetramer interface [polypeptide binding]; other site 572264009219 homodimer interface [polypeptide binding]; other site 572264009220 active site 572264009221 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 572264009222 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 572264009223 Divergent PAP2 family; Region: DUF212; pfam02681 572264009224 Predicted permeases [General function prediction only]; Region: RarD; COG2962 572264009225 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 572264009226 antiporter inner membrane protein; Provisional; Region: PRK11670 572264009227 Domain of unknown function DUF59; Region: DUF59; pfam01883 572264009228 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 572264009229 Walker A motif; other site 572264009230 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 572264009231 MoaE interaction surface [polypeptide binding]; other site 572264009232 MoeB interaction surface [polypeptide binding]; other site 572264009233 thiocarboxylated glycine; other site 572264009234 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 572264009235 MoaE homodimer interface [polypeptide binding]; other site 572264009236 MoaD interaction [polypeptide binding]; other site 572264009237 active site residues [active] 572264009238 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 572264009239 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 572264009240 dimer interface [polypeptide binding]; other site 572264009241 putative functional site; other site 572264009242 putative MPT binding site; other site 572264009243 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 572264009244 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 572264009245 ATP binding site [chemical binding]; other site 572264009246 substrate interface [chemical binding]; other site 572264009247 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 572264009248 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 572264009249 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572264009250 FeS/SAM binding site; other site 572264009251 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 572264009252 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 572264009253 Uncharacterized conserved protein [Function unknown]; Region: COG5609 572264009254 Uncharacterized conserved protein [Function unknown]; Region: COG2427 572264009255 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 572264009256 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 572264009257 catalytic loop [active] 572264009258 iron binding site [ion binding]; other site 572264009259 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 572264009260 4Fe-4S binding domain; Region: Fer4; pfam00037 572264009261 4Fe-4S binding domain; Region: Fer4; pfam00037 572264009262 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 572264009263 [4Fe-4S] binding site [ion binding]; other site 572264009264 molybdopterin cofactor binding site; other site 572264009265 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 572264009266 molybdopterin cofactor binding site; other site 572264009267 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 572264009268 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 572264009269 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 572264009270 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 572264009271 Tubulin like; Region: Tubulin_2; pfam13809 572264009272 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 572264009273 metal ion-dependent adhesion site (MIDAS); other site 572264009274 Methyltransferase domain; Region: Methyltransf_23; pfam13489 572264009275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264009276 S-adenosylmethionine binding site [chemical binding]; other site 572264009277 O-methyltransferase; Region: Methyltransf_2; pfam00891 572264009278 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 572264009279 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 572264009280 peptide binding site [polypeptide binding]; other site 572264009281 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 572264009282 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 572264009283 peptide binding site [polypeptide binding]; other site 572264009284 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 572264009285 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 572264009286 peptide binding site [polypeptide binding]; other site 572264009287 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 572264009288 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 572264009289 Transcriptional regulator [Transcription]; Region: LytR; COG1316 572264009290 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 572264009291 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264009292 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572264009293 DNA binding residues [nucleotide binding] 572264009294 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 572264009295 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 572264009296 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 572264009297 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 572264009298 Walker A/P-loop; other site 572264009299 ATP binding site [chemical binding]; other site 572264009300 Q-loop/lid; other site 572264009301 ABC transporter signature motif; other site 572264009302 Walker B; other site 572264009303 D-loop; other site 572264009304 H-loop/switch region; other site 572264009305 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264009306 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264009307 putative oxidoreductase; Provisional; Region: PRK11579 572264009308 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 572264009309 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 572264009310 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 572264009311 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 572264009312 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 572264009313 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 572264009314 CAP-like domain; other site 572264009315 active site 572264009316 primary dimer interface [polypeptide binding]; other site 572264009317 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572264009318 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572264009319 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572264009320 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572264009321 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 572264009322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264009323 ATP binding site [chemical binding]; other site 572264009324 Mg2+ binding site [ion binding]; other site 572264009325 G-X-G motif; other site 572264009326 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 572264009327 anchoring element; other site 572264009328 dimer interface [polypeptide binding]; other site 572264009329 ATP binding site [chemical binding]; other site 572264009330 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 572264009331 active site 572264009332 putative metal-binding site [ion binding]; other site 572264009333 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 572264009334 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 572264009335 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 572264009336 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 572264009337 protein binding site [polypeptide binding]; other site 572264009338 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264009339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264009340 active site 572264009341 phosphorylation site [posttranslational modification] 572264009342 intermolecular recognition site; other site 572264009343 dimerization interface [polypeptide binding]; other site 572264009344 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264009345 DNA binding site [nucleotide binding] 572264009346 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 572264009347 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572264009348 FeS/SAM binding site; other site 572264009349 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 572264009350 Class III ribonucleotide reductase; Region: RNR_III; cd01675 572264009351 effector binding site; other site 572264009352 active site 572264009353 Zn binding site [ion binding]; other site 572264009354 glycine loop; other site 572264009355 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 572264009356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 572264009357 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 572264009358 active site 572264009359 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 572264009360 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 572264009361 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 572264009362 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 572264009363 active site 572264009364 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 572264009365 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 572264009366 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 572264009367 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 572264009368 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 572264009369 active site 572264009370 catalytic site [active] 572264009371 substrate binding site [chemical binding]; other site 572264009372 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 572264009373 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 572264009374 catalytic residues [active] 572264009375 Family of unknown function (DUF648); Region: DUF648; pfam04890 572264009376 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 572264009377 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 572264009378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264009379 Walker A/P-loop; other site 572264009380 ATP binding site [chemical binding]; other site 572264009381 Q-loop/lid; other site 572264009382 ABC transporter signature motif; other site 572264009383 Walker B; other site 572264009384 D-loop; other site 572264009385 H-loop/switch region; other site 572264009386 aconitate hydratase; Validated; Region: PRK09277 572264009387 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 572264009388 substrate binding site [chemical binding]; other site 572264009389 ligand binding site [chemical binding]; other site 572264009390 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 572264009391 substrate binding site [chemical binding]; other site 572264009392 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 572264009393 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 572264009394 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 572264009395 NodB motif; other site 572264009396 active site 572264009397 catalytic site [active] 572264009398 metal binding site [ion binding]; metal-binding site 572264009399 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 572264009400 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 572264009401 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 572264009402 putative dimer interface [polypeptide binding]; other site 572264009403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264009404 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264009405 putative substrate translocation pore; other site 572264009406 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 572264009407 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 572264009408 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 572264009409 nudix motif; other site 572264009410 SAP domain; Region: SAP; pfam02037 572264009411 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 572264009412 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 572264009413 dimer interface [polypeptide binding]; other site 572264009414 active site 572264009415 acyl-CoA synthetase; Validated; Region: PRK07638 572264009416 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572264009417 acyl-activating enzyme (AAE) consensus motif; other site 572264009418 AMP binding site [chemical binding]; other site 572264009419 active site 572264009420 CoA binding site [chemical binding]; other site 572264009421 BioY family; Region: BioY; pfam02632 572264009422 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 572264009423 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 572264009424 dimer interface [polypeptide binding]; other site 572264009425 acyl-activating enzyme (AAE) consensus motif; other site 572264009426 putative active site [active] 572264009427 AMP binding site [chemical binding]; other site 572264009428 putative CoA binding site [chemical binding]; other site 572264009429 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 572264009430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264009431 H-loop/switch region; other site 572264009432 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264009433 Coenzyme A binding pocket [chemical binding]; other site 572264009434 S-layer homology domain; Region: SLH; pfam00395 572264009435 S-layer homology domain; Region: SLH; pfam00395 572264009436 S-layer homology domain; Region: SLH; pfam00395 572264009437 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 572264009438 active site 572264009439 catalytic motif [active] 572264009440 Zn binding site [ion binding]; other site 572264009441 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 572264009442 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 572264009443 amidase catalytic site [active] 572264009444 Zn binding residues [ion binding]; other site 572264009445 substrate binding site [chemical binding]; other site 572264009446 active site 572264009447 Protein phosphatase 2C; Region: PP2C_2; pfam13672 572264009448 Uncharacterized conserved protein [Function unknown]; Region: COG1284 572264009449 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 572264009450 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572264009451 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 572264009452 dimer interface [polypeptide binding]; other site 572264009453 putative metal binding site [ion binding]; other site 572264009454 PAS domain S-box; Region: sensory_box; TIGR00229 572264009455 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572264009456 putative active site [active] 572264009457 heme pocket [chemical binding]; other site 572264009458 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 572264009459 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572264009460 putative active site [active] 572264009461 heme pocket [chemical binding]; other site 572264009462 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264009463 dimer interface [polypeptide binding]; other site 572264009464 phosphorylation site [posttranslational modification] 572264009465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264009466 ATP binding site [chemical binding]; other site 572264009467 Mg2+ binding site [ion binding]; other site 572264009468 G-X-G motif; other site 572264009469 Predicted esterase [General function prediction only]; Region: COG0400 572264009470 putative hydrolase; Provisional; Region: PRK11460 572264009471 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 572264009472 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572264009473 Zn binding site [ion binding]; other site 572264009474 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 572264009475 Zn binding site [ion binding]; other site 572264009476 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 572264009477 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 572264009478 Na binding site [ion binding]; other site 572264009479 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 572264009480 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 572264009481 active site 572264009482 FMN binding site [chemical binding]; other site 572264009483 substrate binding site [chemical binding]; other site 572264009484 3Fe-4S cluster binding site [ion binding]; other site 572264009485 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 572264009486 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 572264009487 FMN binding site [chemical binding]; other site 572264009488 active site 572264009489 substrate binding site [chemical binding]; other site 572264009490 catalytic residue [active] 572264009491 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 572264009492 agmatinase; Region: agmatinase; TIGR01230 572264009493 Agmatinase-like family; Region: Agmatinase-like; cd09990 572264009494 active site 572264009495 oligomer interface [polypeptide binding]; other site 572264009496 Mn binding site [ion binding]; other site 572264009497 imidazolonepropionase; Validated; Region: PRK09356 572264009498 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 572264009499 active site 572264009500 urocanate hydratase; Provisional; Region: PRK05414 572264009501 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 572264009502 active sites [active] 572264009503 tetramer interface [polypeptide binding]; other site 572264009504 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 572264009505 hexamer interface [polypeptide binding]; other site 572264009506 RNA binding site [nucleotide binding]; other site 572264009507 Histidine-zinc binding site [chemical binding]; other site 572264009508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264009509 S-adenosylmethionine binding site [chemical binding]; other site 572264009510 DJ-1 family protein; Region: not_thiJ; TIGR01383 572264009511 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 572264009512 conserved cys residue [active] 572264009513 AAA domain; Region: AAA_28; pfam13521 572264009514 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 572264009515 active site 572264009516 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 572264009517 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009518 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009519 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009520 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009521 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009522 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009523 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009524 Domain of unknown function DUF11; Region: DUF11; cl17728 572264009525 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009526 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009527 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009528 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009529 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009530 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009531 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009532 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009533 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009534 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009535 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264009536 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 572264009537 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 572264009538 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 572264009539 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 572264009540 EamA-like transporter family; Region: EamA; pfam00892 572264009541 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 572264009542 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 572264009543 metal binding site [ion binding]; metal-binding site 572264009544 dimer interface [polypeptide binding]; other site 572264009545 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 572264009546 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 572264009547 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 572264009548 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264009549 Walker A/P-loop; other site 572264009550 ATP binding site [chemical binding]; other site 572264009551 Q-loop/lid; other site 572264009552 ABC transporter signature motif; other site 572264009553 Walker B; other site 572264009554 D-loop; other site 572264009555 H-loop/switch region; other site 572264009556 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 572264009557 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572264009558 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 572264009559 putative dimerization interface [polypeptide binding]; other site 572264009560 putative substrate binding pocket [chemical binding]; other site 572264009561 holin-like protein; Validated; Region: PRK01658 572264009562 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 572264009563 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 572264009564 nudix motif; other site 572264009565 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 572264009566 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 572264009567 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 572264009568 amidase catalytic site [active] 572264009569 Zn binding residues [ion binding]; other site 572264009570 substrate binding site [chemical binding]; other site 572264009571 S-layer homology domain; Region: SLH; pfam00395 572264009572 S-layer homology domain; Region: SLH; pfam00395 572264009573 S-layer homology domain; Region: SLH; pfam00395 572264009574 Nuclease-related domain; Region: NERD; pfam08378 572264009575 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 572264009576 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 572264009577 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 572264009578 Walker A/P-loop; other site 572264009579 ATP binding site [chemical binding]; other site 572264009580 Q-loop/lid; other site 572264009581 ABC transporter signature motif; other site 572264009582 Walker B; other site 572264009583 D-loop; other site 572264009584 H-loop/switch region; other site 572264009585 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 572264009586 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 572264009587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264009588 Walker A/P-loop; other site 572264009589 ATP binding site [chemical binding]; other site 572264009590 Q-loop/lid; other site 572264009591 ABC transporter signature motif; other site 572264009592 Walker B; other site 572264009593 D-loop; other site 572264009594 H-loop/switch region; other site 572264009595 hypothetical protein; Provisional; Region: PRK01844 572264009596 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 572264009597 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 572264009598 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 572264009599 TPP-binding site [chemical binding]; other site 572264009600 dimer interface [polypeptide binding]; other site 572264009601 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 572264009602 PYR/PP interface [polypeptide binding]; other site 572264009603 dimer interface [polypeptide binding]; other site 572264009604 TPP binding site [chemical binding]; other site 572264009605 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 572264009606 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 572264009607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264009608 dimer interface [polypeptide binding]; other site 572264009609 conserved gate region; other site 572264009610 ABC-ATPase subunit interface; other site 572264009611 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 572264009612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264009613 dimer interface [polypeptide binding]; other site 572264009614 conserved gate region; other site 572264009615 ABC-ATPase subunit interface; other site 572264009616 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 572264009617 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 572264009618 Walker A/P-loop; other site 572264009619 ATP binding site [chemical binding]; other site 572264009620 Q-loop/lid; other site 572264009621 ABC transporter signature motif; other site 572264009622 Walker B; other site 572264009623 D-loop; other site 572264009624 H-loop/switch region; other site 572264009625 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 572264009626 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572264009627 membrane-bound complex binding site; other site 572264009628 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 572264009629 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 572264009630 active site 572264009631 metal binding site [ion binding]; metal-binding site 572264009632 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 572264009633 hypothetical protein; Provisional; Region: PRK01546 572264009634 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 572264009635 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 572264009636 catalytic residues [active] 572264009637 catalytic nucleophile [active] 572264009638 LexA repressor; Validated; Region: PRK00215 572264009639 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264009640 putative DNA binding site [nucleotide binding]; other site 572264009641 putative Zn2+ binding site [ion binding]; other site 572264009642 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 572264009643 Catalytic site [active] 572264009644 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 572264009645 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 572264009646 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 572264009647 Predicted transcriptional regulators [Transcription]; Region: COG1695 572264009648 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 572264009649 glutamine synthetase, type I; Region: GlnA; TIGR00653 572264009650 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 572264009651 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 572264009652 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 572264009653 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 572264009654 DNA binding residues [nucleotide binding] 572264009655 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 572264009656 Aluminium resistance protein; Region: Alum_res; pfam06838 572264009657 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 572264009658 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 572264009659 HflX GTPase family; Region: HflX; cd01878 572264009660 G1 box; other site 572264009661 GTP/Mg2+ binding site [chemical binding]; other site 572264009662 Switch I region; other site 572264009663 G2 box; other site 572264009664 G3 box; other site 572264009665 Switch II region; other site 572264009666 G4 box; other site 572264009667 G5 box; other site 572264009668 Predicted membrane protein [Function unknown]; Region: COG2860 572264009669 UPF0126 domain; Region: UPF0126; pfam03458 572264009670 UPF0126 domain; Region: UPF0126; pfam03458 572264009671 stage V sporulation protein K; Region: spore_V_K; TIGR02881 572264009672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264009673 Walker A motif; other site 572264009674 ATP binding site [chemical binding]; other site 572264009675 Walker B motif; other site 572264009676 arginine finger; other site 572264009677 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 572264009678 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 572264009679 active site 572264009680 catalytic residues [active] 572264009681 DNA binding site [nucleotide binding] 572264009682 Int/Topo IB signature motif; other site 572264009683 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 572264009684 bacterial Hfq-like; Region: Hfq; cd01716 572264009685 hexamer interface [polypeptide binding]; other site 572264009686 Sm1 motif; other site 572264009687 RNA binding site [nucleotide binding]; other site 572264009688 Sm2 motif; other site 572264009689 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 572264009690 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 572264009691 Bacterial SH3 domain; Region: SH3_3; pfam08239 572264009692 Bacterial SH3 domain; Region: SH3_3; pfam08239 572264009693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 572264009694 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 572264009695 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 572264009696 active site 572264009697 phosphorylation site [posttranslational modification] 572264009698 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 572264009699 active site 572264009700 P-loop; other site 572264009701 phosphorylation site [posttranslational modification] 572264009702 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 572264009703 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 572264009704 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 572264009705 putative substrate binding site [chemical binding]; other site 572264009706 putative ATP binding site [chemical binding]; other site 572264009707 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 572264009708 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 572264009709 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 572264009710 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 572264009711 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 572264009712 dimer interface [polypeptide binding]; other site 572264009713 active site 572264009714 metal binding site [ion binding]; metal-binding site 572264009715 Predicted membrane protein [Function unknown]; Region: COG2322 572264009716 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 572264009717 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 572264009718 Glyco_18 domain; Region: Glyco_18; smart00636 572264009719 putative active site [active] 572264009720 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 572264009721 phosphodiesterase YaeI; Provisional; Region: PRK11340 572264009722 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 572264009723 putative active site [active] 572264009724 putative metal binding site [ion binding]; other site 572264009725 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 572264009726 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 572264009727 IHF dimer interface [polypeptide binding]; other site 572264009728 IHF - DNA interface [nucleotide binding]; other site 572264009729 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 572264009730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264009731 Coenzyme A binding pocket [chemical binding]; other site 572264009732 Abortive infection C-terminus; Region: Abi_C; pfam14355 572264009733 Restriction endonuclease; Region: Mrr_cat; pfam04471 572264009734 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 572264009735 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 572264009736 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 572264009737 metal-binding site [ion binding] 572264009738 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 572264009739 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 572264009740 metal-binding site [ion binding] 572264009741 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572264009742 Soluble P-type ATPase [General function prediction only]; Region: COG4087 572264009743 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 572264009744 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 572264009745 metal-binding site [ion binding] 572264009746 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 572264009747 putative homodimer interface [polypeptide binding]; other site 572264009748 putative homotetramer interface [polypeptide binding]; other site 572264009749 putative allosteric switch controlling residues; other site 572264009750 putative metal binding site [ion binding]; other site 572264009751 putative homodimer-homodimer interface [polypeptide binding]; other site 572264009752 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 572264009753 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 572264009754 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 572264009755 Walker A/P-loop; other site 572264009756 ATP binding site [chemical binding]; other site 572264009757 Q-loop/lid; other site 572264009758 ABC transporter signature motif; other site 572264009759 Walker B; other site 572264009760 D-loop; other site 572264009761 H-loop/switch region; other site 572264009762 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 572264009763 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572264009764 ABC-ATPase subunit interface; other site 572264009765 dimer interface [polypeptide binding]; other site 572264009766 putative PBP binding regions; other site 572264009767 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 572264009768 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572264009769 ABC-ATPase subunit interface; other site 572264009770 dimer interface [polypeptide binding]; other site 572264009771 putative PBP binding regions; other site 572264009772 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 572264009773 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 572264009774 putative ligand binding residues [chemical binding]; other site 572264009775 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 572264009776 active site 572264009777 putative catalytic site [active] 572264009778 DNA binding site [nucleotide binding] 572264009779 putative phosphate binding site [ion binding]; other site 572264009780 metal binding site A [ion binding]; metal-binding site 572264009781 AP binding site [nucleotide binding]; other site 572264009782 metal binding site B [ion binding]; metal-binding site 572264009783 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 572264009784 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 572264009785 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 572264009786 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 572264009787 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 572264009788 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 572264009789 DNA binding site [nucleotide binding] 572264009790 active site 572264009791 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 572264009792 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 572264009793 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 572264009794 minor groove reading motif; other site 572264009795 helix-hairpin-helix signature motif; other site 572264009796 substrate binding pocket [chemical binding]; other site 572264009797 active site 572264009798 peptidase T; Region: peptidase-T; TIGR01882 572264009799 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 572264009800 metal binding site [ion binding]; metal-binding site 572264009801 dimer interface [polypeptide binding]; other site 572264009802 Predicted membrane protein [Function unknown]; Region: COG2364 572264009803 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 572264009804 hypothetical protein; Provisional; Region: PRK06764 572264009805 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572264009806 catalytic core [active] 572264009807 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572264009808 PAS domain S-box; Region: sensory_box; TIGR00229 572264009809 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572264009810 putative active site [active] 572264009811 heme pocket [chemical binding]; other site 572264009812 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572264009813 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572264009814 metal binding site [ion binding]; metal-binding site 572264009815 active site 572264009816 I-site; other site 572264009817 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572264009818 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 572264009819 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 572264009820 active site 572264009821 homodimer interface [polypeptide binding]; other site 572264009822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572264009823 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 572264009824 NAD(P) binding site [chemical binding]; other site 572264009825 active site 572264009826 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 572264009827 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 572264009828 NAD(P) binding site [chemical binding]; other site 572264009829 homodimer interface [polypeptide binding]; other site 572264009830 substrate binding site [chemical binding]; other site 572264009831 active site 572264009832 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 572264009833 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 572264009834 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264009835 active site 572264009836 motif I; other site 572264009837 motif II; other site 572264009838 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 572264009839 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 572264009840 ligand binding site [chemical binding]; other site 572264009841 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 572264009842 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 572264009843 LrgB-like family; Region: LrgB; cl00596 572264009844 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 572264009845 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572264009846 DNA-binding site [nucleotide binding]; DNA binding site 572264009847 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572264009848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264009849 homodimer interface [polypeptide binding]; other site 572264009850 catalytic residue [active] 572264009851 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 572264009852 active site 572264009853 catalytic site [active] 572264009854 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 572264009855 putative active site [active] 572264009856 putative catalytic triad [active] 572264009857 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 572264009858 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 572264009859 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 572264009860 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 572264009861 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 572264009862 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 572264009863 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572264009864 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 572264009865 Sulfatase; Region: Sulfatase; pfam00884 572264009866 Tetratricopeptide repeat; Region: TPR_16; pfam13432 572264009867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264009868 binding surface 572264009869 TPR motif; other site 572264009870 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 572264009871 G1 box; other site 572264009872 GTP/Mg2+ binding site [chemical binding]; other site 572264009873 Switch I region; other site 572264009874 G3 box; other site 572264009875 Switch II region; other site 572264009876 G4 box; other site 572264009877 G5 box; other site 572264009878 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 572264009879 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 572264009880 active site 572264009881 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 572264009882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264009883 ATP binding site [chemical binding]; other site 572264009884 Mg2+ binding site [ion binding]; other site 572264009885 G-X-G motif; other site 572264009886 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 572264009887 ATP binding site [chemical binding]; other site 572264009888 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 572264009889 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 572264009890 MutS domain I; Region: MutS_I; pfam01624 572264009891 MutS domain II; Region: MutS_II; pfam05188 572264009892 MutS domain III; Region: MutS_III; pfam05192 572264009893 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 572264009894 Walker A/P-loop; other site 572264009895 ATP binding site [chemical binding]; other site 572264009896 Q-loop/lid; other site 572264009897 ABC transporter signature motif; other site 572264009898 Walker B; other site 572264009899 D-loop; other site 572264009900 H-loop/switch region; other site 572264009901 Outer spore coat protein E (CotE); Region: CotE; pfam10628 572264009902 Predicted membrane protein [Function unknown]; Region: COG4550 572264009903 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 572264009904 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 572264009905 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572264009906 FeS/SAM binding site; other site 572264009907 TRAM domain; Region: TRAM; pfam01938 572264009908 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 572264009909 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 572264009910 TPP-binding site [chemical binding]; other site 572264009911 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 572264009912 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 572264009913 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 572264009914 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 572264009915 dimer interface [polypeptide binding]; other site 572264009916 PYR/PP interface [polypeptide binding]; other site 572264009917 TPP binding site [chemical binding]; other site 572264009918 substrate binding site [chemical binding]; other site 572264009919 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 572264009920 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 572264009921 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 572264009922 active site 572264009923 dimer interface [polypeptide binding]; other site 572264009924 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 572264009925 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 572264009926 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 572264009927 putative active site [active] 572264009928 metal binding site [ion binding]; metal-binding site 572264009929 homodimer binding site [polypeptide binding]; other site 572264009930 phosphodiesterase; Provisional; Region: PRK12704 572264009931 Uncharacterized conserved protein [Function unknown]; Region: COG3334 572264009932 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572264009933 Zn2+ binding site [ion binding]; other site 572264009934 Mg2+ binding site [ion binding]; other site 572264009935 recombinase A; Provisional; Region: recA; PRK09354 572264009936 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 572264009937 hexamer interface [polypeptide binding]; other site 572264009938 Walker A motif; other site 572264009939 ATP binding site [chemical binding]; other site 572264009940 Walker B motif; other site 572264009941 competence damage-inducible protein A; Provisional; Region: PRK00549 572264009942 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 572264009943 putative MPT binding site; other site 572264009944 Competence-damaged protein; Region: CinA; pfam02464 572264009945 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 572264009946 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 572264009947 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264009948 non-specific DNA binding site [nucleotide binding]; other site 572264009949 salt bridge; other site 572264009950 sequence-specific DNA binding site [nucleotide binding]; other site 572264009951 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 572264009952 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 572264009953 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 572264009954 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 572264009955 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 572264009956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572264009957 NAD(P) binding site [chemical binding]; other site 572264009958 active site 572264009959 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 572264009960 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 572264009961 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 572264009962 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 572264009963 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 572264009964 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 572264009965 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 572264009966 TM-ABC transporter signature motif; other site 572264009967 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 572264009968 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 572264009969 TM-ABC transporter signature motif; other site 572264009970 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 572264009971 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 572264009972 Walker A/P-loop; other site 572264009973 ATP binding site [chemical binding]; other site 572264009974 Q-loop/lid; other site 572264009975 ABC transporter signature motif; other site 572264009976 Walker B; other site 572264009977 D-loop; other site 572264009978 H-loop/switch region; other site 572264009979 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 572264009980 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 572264009981 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 572264009982 ligand binding site [chemical binding]; other site 572264009983 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 572264009984 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572264009985 DNA-binding site [nucleotide binding]; DNA binding site 572264009986 UTRA domain; Region: UTRA; pfam07702 572264009987 Tetraspanin family; Region: Tetraspannin; pfam00335 572264009988 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 572264009989 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 572264009990 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 572264009991 YlzJ-like protein; Region: YlzJ; pfam14035 572264009992 Clp protease; Region: CLP_protease; pfam00574 572264009993 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 572264009994 active site 572264009995 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 572264009996 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572264009997 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 572264009998 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 572264009999 dihydrodipicolinate synthase; Region: dapA; TIGR00674 572264010000 dimer interface [polypeptide binding]; other site 572264010001 active site 572264010002 catalytic residue [active] 572264010003 aspartate kinase I; Reviewed; Region: PRK08210 572264010004 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 572264010005 nucleotide binding site [chemical binding]; other site 572264010006 substrate binding site [chemical binding]; other site 572264010007 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 572264010008 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 572264010009 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 572264010010 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 572264010011 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 572264010012 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 572264010013 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 572264010014 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 572264010015 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 572264010016 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 572264010017 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 572264010018 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 572264010019 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 572264010020 NodB motif; other site 572264010021 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 572264010022 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 572264010023 RNase E interface [polypeptide binding]; other site 572264010024 trimer interface [polypeptide binding]; other site 572264010025 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 572264010026 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 572264010027 RNase E interface [polypeptide binding]; other site 572264010028 trimer interface [polypeptide binding]; other site 572264010029 active site 572264010030 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 572264010031 putative nucleic acid binding region [nucleotide binding]; other site 572264010032 G-X-X-G motif; other site 572264010033 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 572264010034 RNA binding site [nucleotide binding]; other site 572264010035 domain interface; other site 572264010036 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 572264010037 16S/18S rRNA binding site [nucleotide binding]; other site 572264010038 S13e-L30e interaction site [polypeptide binding]; other site 572264010039 25S rRNA binding site [nucleotide binding]; other site 572264010040 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 572264010041 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 572264010042 active site 572264010043 Riboflavin kinase; Region: Flavokinase; smart00904 572264010044 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 572264010045 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 572264010046 RNA binding site [nucleotide binding]; other site 572264010047 active site 572264010048 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 572264010049 Protein of unknown function (DUF503); Region: DUF503; pfam04456 572264010050 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 572264010051 translation initiation factor IF-2; Region: IF-2; TIGR00487 572264010052 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 572264010053 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 572264010054 G1 box; other site 572264010055 putative GEF interaction site [polypeptide binding]; other site 572264010056 GTP/Mg2+ binding site [chemical binding]; other site 572264010057 Switch I region; other site 572264010058 G2 box; other site 572264010059 G3 box; other site 572264010060 Switch II region; other site 572264010061 G4 box; other site 572264010062 G5 box; other site 572264010063 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 572264010064 Translation-initiation factor 2; Region: IF-2; pfam11987 572264010065 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 572264010066 hypothetical protein; Provisional; Region: PRK07714 572264010067 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 572264010068 putative RNA binding cleft [nucleotide binding]; other site 572264010069 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 572264010070 NusA N-terminal domain; Region: NusA_N; pfam08529 572264010071 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 572264010072 RNA binding site [nucleotide binding]; other site 572264010073 homodimer interface [polypeptide binding]; other site 572264010074 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 572264010075 G-X-X-G motif; other site 572264010076 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 572264010077 G-X-X-G motif; other site 572264010078 ribosome maturation protein RimP; Reviewed; Region: PRK00092 572264010079 Sm and related proteins; Region: Sm_like; cl00259 572264010080 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 572264010081 putative oligomer interface [polypeptide binding]; other site 572264010082 putative RNA binding site [nucleotide binding]; other site 572264010083 DNA polymerase III PolC; Validated; Region: polC; PRK00448 572264010084 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 572264010085 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 572264010086 putative active site [active] 572264010087 putative NTP binding site [chemical binding]; other site 572264010088 putative nucleic acid binding site [nucleotide binding]; other site 572264010089 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 572264010090 active site 572264010091 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 572264010092 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 572264010093 generic binding surface II; other site 572264010094 generic binding surface I; other site 572264010095 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 572264010096 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 572264010097 active site 572264010098 exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573 572264010099 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 572264010100 active site 572264010101 catalytic site [active] 572264010102 substrate binding site [chemical binding]; other site 572264010103 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 572264010104 prolyl-tRNA synthetase; Provisional; Region: PRK09194 572264010105 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 572264010106 dimer interface [polypeptide binding]; other site 572264010107 motif 1; other site 572264010108 active site 572264010109 motif 2; other site 572264010110 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 572264010111 putative deacylase active site [active] 572264010112 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 572264010113 active site 572264010114 motif 3; other site 572264010115 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 572264010116 anticodon binding site; other site 572264010117 RIP metalloprotease RseP; Region: TIGR00054 572264010118 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 572264010119 active site 572264010120 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 572264010121 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 572264010122 protein binding site [polypeptide binding]; other site 572264010123 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 572264010124 putative substrate binding region [chemical binding]; other site 572264010125 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 572264010126 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 572264010127 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 572264010128 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 572264010129 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 572264010130 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 572264010131 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 572264010132 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 572264010133 catalytic residue [active] 572264010134 putative FPP diphosphate binding site; other site 572264010135 putative FPP binding hydrophobic cleft; other site 572264010136 dimer interface [polypeptide binding]; other site 572264010137 putative IPP diphosphate binding site; other site 572264010138 ribosome recycling factor; Reviewed; Region: frr; PRK00083 572264010139 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 572264010140 hinge region; other site 572264010141 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 572264010142 putative nucleotide binding site [chemical binding]; other site 572264010143 uridine monophosphate binding site [chemical binding]; other site 572264010144 homohexameric interface [polypeptide binding]; other site 572264010145 elongation factor Ts; Provisional; Region: tsf; PRK09377 572264010146 UBA/TS-N domain; Region: UBA; pfam00627 572264010147 Elongation factor TS; Region: EF_TS; pfam00889 572264010148 Elongation factor TS; Region: EF_TS; pfam00889 572264010149 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 572264010150 rRNA interaction site [nucleotide binding]; other site 572264010151 S8 interaction site; other site 572264010152 putative laminin-1 binding site; other site 572264010153 transcriptional repressor CodY; Validated; Region: PRK04158 572264010154 CodY GAF-like domain; Region: CodY; pfam06018 572264010155 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 572264010156 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 572264010157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264010158 Walker A motif; other site 572264010159 ATP binding site [chemical binding]; other site 572264010160 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 572264010161 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 572264010162 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 572264010163 active site 572264010164 HslU subunit interaction site [polypeptide binding]; other site 572264010165 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 572264010166 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 572264010167 active site 572264010168 Int/Topo IB signature motif; other site 572264010169 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 572264010170 Glucose inhibited division protein A; Region: GIDA; pfam01134 572264010171 DNA topoisomerase I; Validated; Region: PRK05582 572264010172 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 572264010173 active site 572264010174 interdomain interaction site; other site 572264010175 putative metal-binding site [ion binding]; other site 572264010176 nucleotide binding site [chemical binding]; other site 572264010177 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 572264010178 domain I; other site 572264010179 DNA binding groove [nucleotide binding] 572264010180 phosphate binding site [ion binding]; other site 572264010181 domain II; other site 572264010182 domain III; other site 572264010183 nucleotide binding site [chemical binding]; other site 572264010184 catalytic site [active] 572264010185 domain IV; other site 572264010186 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 572264010187 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 572264010188 DNA protecting protein DprA; Region: dprA; TIGR00732 572264010189 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 572264010190 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 572264010191 CoA binding domain; Region: CoA_binding; smart00881 572264010192 CoA-ligase; Region: Ligase_CoA; pfam00549 572264010193 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 572264010194 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 572264010195 CoA-ligase; Region: Ligase_CoA; pfam00549 572264010196 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 572264010197 RNA/DNA hybrid binding site [nucleotide binding]; other site 572264010198 active site 572264010199 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 572264010200 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 572264010201 GTP/Mg2+ binding site [chemical binding]; other site 572264010202 G4 box; other site 572264010203 G5 box; other site 572264010204 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 572264010205 G1 box; other site 572264010206 G1 box; other site 572264010207 GTP/Mg2+ binding site [chemical binding]; other site 572264010208 Switch I region; other site 572264010209 G2 box; other site 572264010210 G2 box; other site 572264010211 G3 box; other site 572264010212 G3 box; other site 572264010213 Switch II region; other site 572264010214 Switch II region; other site 572264010215 G4 box; other site 572264010216 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 572264010217 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 572264010218 Catalytic site [active] 572264010219 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 572264010220 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 572264010221 Ribosomal protein L19 leader 572264010222 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 572264010223 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 572264010224 RimM N-terminal domain; Region: RimM; pfam01782 572264010225 PRC-barrel domain; Region: PRC; pfam05239 572264010226 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 572264010227 KH domain; Region: KH_4; pfam13083 572264010228 G-X-X-G motif; other site 572264010229 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 572264010230 signal recognition particle protein; Provisional; Region: PRK10867 572264010231 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 572264010232 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 572264010233 P loop; other site 572264010234 GTP binding site [chemical binding]; other site 572264010235 Signal peptide binding domain; Region: SRP_SPB; pfam02978 572264010236 putative DNA-binding protein; Validated; Region: PRK00118 572264010237 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 572264010238 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 572264010239 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 572264010240 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 572264010241 P loop; other site 572264010242 GTP binding site [chemical binding]; other site 572264010243 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 572264010244 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 572264010245 Walker A/P-loop; other site 572264010246 ATP binding site [chemical binding]; other site 572264010247 Q-loop/lid; other site 572264010248 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 572264010249 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 572264010250 ABC transporter signature motif; other site 572264010251 Walker B; other site 572264010252 D-loop; other site 572264010253 H-loop/switch region; other site 572264010254 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 572264010255 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 572264010256 dimerization interface [polypeptide binding]; other site 572264010257 active site 572264010258 metal binding site [ion binding]; metal-binding site 572264010259 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 572264010260 dsRNA binding site [nucleotide binding]; other site 572264010261 acyl carrier protein; Provisional; Region: acpP; PRK00982 572264010262 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 572264010263 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 572264010264 NAD(P) binding site [chemical binding]; other site 572264010265 homotetramer interface [polypeptide binding]; other site 572264010266 homodimer interface [polypeptide binding]; other site 572264010267 active site 572264010268 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 572264010269 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 572264010270 putative phosphate acyltransferase; Provisional; Region: PRK05331 572264010271 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 572264010272 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 572264010273 active site 2 [active] 572264010274 active site 1 [active] 572264010275 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 572264010276 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 572264010277 generic binding surface II; other site 572264010278 ssDNA binding site; other site 572264010279 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572264010280 ATP binding site [chemical binding]; other site 572264010281 putative Mg++ binding site [ion binding]; other site 572264010282 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572264010283 nucleotide binding region [chemical binding]; other site 572264010284 ATP-binding site [chemical binding]; other site 572264010285 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 572264010286 DAK2 domain; Region: Dak2; pfam02734 572264010287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 572264010288 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 572264010289 Thiamine pyrophosphokinase; Region: TPK; cd07995 572264010290 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 572264010291 active site 572264010292 dimerization interface [polypeptide binding]; other site 572264010293 thiamine binding site [chemical binding]; other site 572264010294 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 572264010295 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 572264010296 substrate binding site [chemical binding]; other site 572264010297 hexamer interface [polypeptide binding]; other site 572264010298 metal binding site [ion binding]; metal-binding site 572264010299 GTPase RsgA; Reviewed; Region: PRK00098 572264010300 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 572264010301 RNA binding site [nucleotide binding]; other site 572264010302 homodimer interface [polypeptide binding]; other site 572264010303 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 572264010304 GTPase/Zn-binding domain interface [polypeptide binding]; other site 572264010305 GTP/Mg2+ binding site [chemical binding]; other site 572264010306 G4 box; other site 572264010307 G5 box; other site 572264010308 G1 box; other site 572264010309 Switch I region; other site 572264010310 G2 box; other site 572264010311 G3 box; other site 572264010312 Switch II region; other site 572264010313 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 572264010314 Catalytic domain of Protein Kinases; Region: PKc; cd00180 572264010315 active site 572264010316 ATP binding site [chemical binding]; other site 572264010317 substrate binding site [chemical binding]; other site 572264010318 activation loop (A-loop); other site 572264010319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 572264010320 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 572264010321 PASTA domain; Region: PASTA; pfam03793 572264010322 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 572264010323 Protein phosphatase 2C; Region: PP2C; pfam00481 572264010324 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 572264010325 active site 572264010326 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 572264010327 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572264010328 FeS/SAM binding site; other site 572264010329 16S rRNA methyltransferase B; Provisional; Region: PRK14902 572264010330 NusB family; Region: NusB; pfam01029 572264010331 putative RNA binding site [nucleotide binding]; other site 572264010332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264010333 S-adenosylmethionine binding site [chemical binding]; other site 572264010334 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 572264010335 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 572264010336 putative active site [active] 572264010337 substrate binding site [chemical binding]; other site 572264010338 putative cosubstrate binding site; other site 572264010339 catalytic site [active] 572264010340 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 572264010341 substrate binding site [chemical binding]; other site 572264010342 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 572264010343 active site 572264010344 catalytic residues [active] 572264010345 metal binding site [ion binding]; metal-binding site 572264010346 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572264010347 primosomal protein N' Region: priA; TIGR00595 572264010348 ATP binding site [chemical binding]; other site 572264010349 putative Mg++ binding site [ion binding]; other site 572264010350 helicase superfamily c-terminal domain; Region: HELICc; smart00490 572264010351 nucleotide binding region [chemical binding]; other site 572264010352 ATP-binding site [chemical binding]; other site 572264010353 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 572264010354 Flavoprotein; Region: Flavoprotein; pfam02441 572264010355 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 572264010356 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 572264010357 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 572264010358 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 572264010359 catalytic site [active] 572264010360 G-X2-G-X-G-K; other site 572264010361 hypothetical protein; Provisional; Region: PRK04323 572264010362 hypothetical protein; Provisional; Region: PRK11820 572264010363 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 572264010364 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 572264010365 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 572264010366 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 572264010367 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572264010368 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 572264010369 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264010370 motif II; other site 572264010371 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 572264010372 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 572264010373 Domain of unknown function (DUF814); Region: DUF814; pfam05670 572264010374 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 572264010375 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 572264010376 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 572264010377 active site 572264010378 Protein of unknown function (DUF664); Region: DUF664; pfam04978 572264010379 DinB superfamily; Region: DinB_2; pfam12867 572264010380 YoqO-like protein; Region: YoqO; pfam14037 572264010381 YoqO-like protein; Region: YoqO; pfam14037 572264010382 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 572264010383 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 572264010384 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 572264010385 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264010386 motif II; other site 572264010387 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572264010388 active site 572264010389 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 572264010390 active site 572264010391 dimer interface [polypeptide binding]; other site 572264010392 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 572264010393 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 572264010394 heterodimer interface [polypeptide binding]; other site 572264010395 active site 572264010396 FMN binding site [chemical binding]; other site 572264010397 homodimer interface [polypeptide binding]; other site 572264010398 substrate binding site [chemical binding]; other site 572264010399 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 572264010400 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 572264010401 FAD binding pocket [chemical binding]; other site 572264010402 FAD binding motif [chemical binding]; other site 572264010403 phosphate binding motif [ion binding]; other site 572264010404 beta-alpha-beta structure motif; other site 572264010405 NAD binding pocket [chemical binding]; other site 572264010406 Iron coordination center [ion binding]; other site 572264010407 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 572264010408 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 572264010409 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 572264010410 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 572264010411 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 572264010412 ATP-grasp domain; Region: ATP-grasp_4; cl17255 572264010413 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 572264010414 IMP binding site; other site 572264010415 dimer interface [polypeptide binding]; other site 572264010416 interdomain contacts; other site 572264010417 partial ornithine binding site; other site 572264010418 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 572264010419 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 572264010420 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 572264010421 catalytic site [active] 572264010422 subunit interface [polypeptide binding]; other site 572264010423 dihydroorotase; Validated; Region: pyrC; PRK09357 572264010424 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 572264010425 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 572264010426 active site 572264010427 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 572264010428 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 572264010429 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 572264010430 PyrR binding site 572264010431 uracil transporter; Provisional; Region: PRK10720 572264010432 PyrR binding site 572264010433 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 572264010434 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572264010435 active site 572264010436 PyrR binding site 572264010437 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 572264010438 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572264010439 RNA binding surface [nucleotide binding]; other site 572264010440 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 572264010441 active site 572264010442 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 572264010443 lipoprotein signal peptidase; Provisional; Region: PRK14787 572264010444 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 572264010445 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 572264010446 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572264010447 active site 572264010448 HIGH motif; other site 572264010449 nucleotide binding site [chemical binding]; other site 572264010450 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 572264010451 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 572264010452 active site 572264010453 KMSKS motif; other site 572264010454 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 572264010455 tRNA binding surface [nucleotide binding]; other site 572264010456 anticodon binding site; other site 572264010457 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 572264010458 DivIVA protein; Region: DivIVA; pfam05103 572264010459 DivIVA domain; Region: DivI1A_domain; TIGR03544 572264010460 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 572264010461 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 572264010462 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572264010463 RNA binding surface [nucleotide binding]; other site 572264010464 YGGT family; Region: YGGT; pfam02325 572264010465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 572264010466 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 572264010467 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 572264010468 catalytic residue [active] 572264010469 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 572264010470 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 572264010471 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 572264010472 sporulation sigma factor SigG; Reviewed; Region: PRK08215 572264010473 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264010474 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572264010475 DNA binding residues [nucleotide binding] 572264010476 sporulation sigma factor SigE; Reviewed; Region: PRK08301 572264010477 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264010478 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572264010479 DNA binding residues [nucleotide binding] 572264010480 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 572264010481 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 572264010482 cell division protein FtsZ; Validated; Region: PRK09330 572264010483 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 572264010484 nucleotide binding site [chemical binding]; other site 572264010485 SulA interaction site; other site 572264010486 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 572264010487 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 572264010488 nucleotide binding site [chemical binding]; other site 572264010489 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 572264010490 Cell division protein FtsA; Region: FtsA; pfam14450 572264010491 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 572264010492 Cell division protein FtsQ; Region: FtsQ; pfam03799 572264010493 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 572264010494 FAD binding domain; Region: FAD_binding_4; pfam01565 572264010495 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 572264010496 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 572264010497 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 572264010498 active site 572264010499 homodimer interface [polypeptide binding]; other site 572264010500 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 572264010501 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 572264010502 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 572264010503 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 572264010504 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 572264010505 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 572264010506 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 572264010507 Mg++ binding site [ion binding]; other site 572264010508 putative catalytic motif [active] 572264010509 putative substrate binding site [chemical binding]; other site 572264010510 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 572264010511 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 572264010512 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 572264010513 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 572264010514 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 572264010515 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 572264010516 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572264010517 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 572264010518 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 572264010519 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 572264010520 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572264010521 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 572264010522 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 572264010523 Cell division protein FtsL; Region: FtsL; cl11433 572264010524 MraW methylase family; Region: Methyltransf_5; pfam01795 572264010525 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 572264010526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 572264010527 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 572264010528 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 572264010529 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 572264010530 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 572264010531 hypothetical protein; Provisional; Region: PRK13688 572264010532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264010533 Coenzyme A binding pocket [chemical binding]; other site 572264010534 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 572264010535 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 572264010536 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 572264010537 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 572264010538 hypothetical protein; Provisional; Region: PRK13670 572264010539 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 572264010540 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 572264010541 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 572264010542 protein binding site [polypeptide binding]; other site 572264010543 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 572264010544 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 572264010545 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 572264010546 active site 572264010547 nucleophile elbow; other site 572264010548 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 572264010549 Nucleoside recognition; Region: Gate; pfam07670 572264010550 Nucleoside recognition; Region: Gate; pfam07670 572264010551 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 572264010552 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 572264010553 active site 572264010554 (T/H)XGH motif; other site 572264010555 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 572264010556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264010557 S-adenosylmethionine binding site [chemical binding]; other site 572264010558 ylbH leader 572264010559 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 572264010560 Protein of unknown function (DUF964); Region: DUF964; pfam06133 572264010561 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572264010562 catalytic core [active] 572264010563 YlbE-like protein; Region: YlbE; pfam14003 572264010564 Putative coat protein; Region: YlbD_coat; pfam14071 572264010565 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 572264010566 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 572264010567 YugN-like family; Region: YugN; pfam08868 572264010568 formamidase; Provisional; Region: amiF; PRK13287 572264010569 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 572264010570 multimer interface [polypeptide binding]; other site 572264010571 active site 572264010572 catalytic triad [active] 572264010573 dimer interface [polypeptide binding]; other site 572264010574 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 572264010575 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 572264010576 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 572264010577 Subunit I/III interface [polypeptide binding]; other site 572264010578 Subunit III/IV interface [polypeptide binding]; other site 572264010579 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 572264010580 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 572264010581 D-pathway; other site 572264010582 Putative ubiquinol binding site [chemical binding]; other site 572264010583 Low-spin heme (heme b) binding site [chemical binding]; other site 572264010584 Putative water exit pathway; other site 572264010585 Binuclear center (heme o3/CuB) [ion binding]; other site 572264010586 K-pathway; other site 572264010587 Putative proton exit pathway; other site 572264010588 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 572264010589 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 572264010590 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 572264010591 Cytochrome c; Region: Cytochrom_C; pfam00034 572264010592 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 572264010593 UbiA prenyltransferase family; Region: UbiA; pfam01040 572264010594 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 572264010595 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 572264010596 pyruvate carboxylase; Reviewed; Region: PRK12999 572264010597 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 572264010598 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 572264010599 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 572264010600 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 572264010601 active site 572264010602 catalytic residues [active] 572264010603 metal binding site [ion binding]; metal-binding site 572264010604 homodimer binding site [polypeptide binding]; other site 572264010605 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 572264010606 carboxyltransferase (CT) interaction site; other site 572264010607 biotinylation site [posttranslational modification]; other site 572264010608 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 572264010609 hypothetical protein; Provisional; Region: PRK13666 572264010610 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 572264010611 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 572264010612 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 572264010613 putative active site [active] 572264010614 PhoH-like protein; Region: PhoH; pfam02562 572264010615 hypothetical protein; Provisional; Region: PRK06733 572264010616 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 572264010617 YlaH-like protein; Region: YlaH; pfam14036 572264010618 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 572264010619 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 572264010620 G1 box; other site 572264010621 putative GEF interaction site [polypeptide binding]; other site 572264010622 GTP/Mg2+ binding site [chemical binding]; other site 572264010623 Switch I region; other site 572264010624 G2 box; other site 572264010625 G3 box; other site 572264010626 Switch II region; other site 572264010627 G4 box; other site 572264010628 G5 box; other site 572264010629 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 572264010630 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 572264010631 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 572264010632 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 572264010633 active site 572264010634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 572264010635 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 572264010636 hypothetical protein; Provisional; Region: PRK04387 572264010637 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 572264010638 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 572264010639 homodimer interface [polypeptide binding]; other site 572264010640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264010641 catalytic residue [active] 572264010642 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 572264010643 transglutaminase; Provisional; Region: tgl; PRK03187 572264010644 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 572264010645 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 572264010646 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 572264010647 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 572264010648 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 572264010649 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 572264010650 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572264010651 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 572264010652 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 572264010653 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 572264010654 E3 interaction surface; other site 572264010655 lipoyl attachment site [posttranslational modification]; other site 572264010656 e3 binding domain; Region: E3_binding; pfam02817 572264010657 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 572264010658 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 572264010659 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 572264010660 alpha subunit interface [polypeptide binding]; other site 572264010661 TPP binding site [chemical binding]; other site 572264010662 heterodimer interface [polypeptide binding]; other site 572264010663 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 572264010664 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 572264010665 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 572264010666 TPP-binding site [chemical binding]; other site 572264010667 heterodimer interface [polypeptide binding]; other site 572264010668 tetramer interface [polypeptide binding]; other site 572264010669 phosphorylation loop region [posttranslational modification] 572264010670 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 572264010671 active site 572264010672 catalytic residues [active] 572264010673 metal binding site [ion binding]; metal-binding site 572264010674 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264010675 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 572264010676 active site 572264010677 motif I; other site 572264010678 motif II; other site 572264010679 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264010680 hypothetical protein; Provisional; Region: PRK13667 572264010681 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 572264010682 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572264010683 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 572264010684 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 572264010685 TrkA-N domain; Region: TrkA_N; pfam02254 572264010686 TrkA-C domain; Region: TrkA_C; pfam02080 572264010687 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 572264010688 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 572264010689 metal binding site [ion binding]; metal-binding site 572264010690 putative dimer interface [polypeptide binding]; other site 572264010691 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 572264010692 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 572264010693 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 572264010694 trimer interface [polypeptide binding]; other site 572264010695 active site 572264010696 substrate binding site [chemical binding]; other site 572264010697 CoA binding site [chemical binding]; other site 572264010698 Transcriptional regulator [Transcription]; Region: LysR; COG0583 572264010699 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572264010700 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 572264010701 dimerization interface [polypeptide binding]; other site 572264010702 FOG: CBS domain [General function prediction only]; Region: COG0517 572264010703 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 572264010704 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 572264010705 Protein of unknown function (DUF458); Region: DUF458; pfam04308 572264010706 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 572264010707 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 572264010708 catalytic residues [active] 572264010709 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 572264010710 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572264010711 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 572264010712 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 572264010713 short chain dehydrogenase; Provisional; Region: PRK07677 572264010714 NAD(P) binding site [chemical binding]; other site 572264010715 substrate binding site [chemical binding]; other site 572264010716 homotetramer interface [polypeptide binding]; other site 572264010717 active site 572264010718 homodimer interface [polypeptide binding]; other site 572264010719 phosphodiesterase YaeI; Provisional; Region: PRK11340 572264010720 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 572264010721 putative active site [active] 572264010722 putative metal binding site [ion binding]; other site 572264010723 polyphosphate kinase; Provisional; Region: PRK05443 572264010724 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 572264010725 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 572264010726 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 572264010727 putative domain interface [polypeptide binding]; other site 572264010728 putative active site [active] 572264010729 catalytic site [active] 572264010730 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 572264010731 putative domain interface [polypeptide binding]; other site 572264010732 putative active site [active] 572264010733 catalytic site [active] 572264010734 exopolyphosphatase; Region: exo_poly_only; TIGR03706 572264010735 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 572264010736 nucleotide binding site [chemical binding]; other site 572264010737 YkyB-like protein; Region: YkyB; pfam14177 572264010738 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 572264010739 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572264010740 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572264010741 I-site; other site 572264010742 active site 572264010743 metal binding site [ion binding]; metal-binding site 572264010744 Phage lysis protein, holin; Region: Phage_holin; cl04675 572264010745 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264010746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264010747 putative substrate translocation pore; other site 572264010748 Predicted transcriptional regulators [Transcription]; Region: COG1695 572264010749 Transcriptional regulator PadR-like family; Region: PadR; cl17335 572264010750 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 572264010751 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 572264010752 THF binding site; other site 572264010753 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 572264010754 substrate binding site [chemical binding]; other site 572264010755 THF binding site; other site 572264010756 zinc-binding site [ion binding]; other site 572264010757 Competence protein J (ComJ); Region: ComJ; pfam11033 572264010758 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 572264010759 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 572264010760 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264010761 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264010762 dimer interface [polypeptide binding]; other site 572264010763 phosphorylation site [posttranslational modification] 572264010764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264010765 ATP binding site [chemical binding]; other site 572264010766 Mg2+ binding site [ion binding]; other site 572264010767 G-X-G motif; other site 572264010768 aminotransferase A; Validated; Region: PRK07683 572264010769 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572264010770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264010771 homodimer interface [polypeptide binding]; other site 572264010772 catalytic residue [active] 572264010773 Transcriptional regulators [Transcription]; Region: PurR; COG1609 572264010774 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 572264010775 DNA binding site [nucleotide binding] 572264010776 domain linker motif; other site 572264010777 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 572264010778 putative dimerization interface [polypeptide binding]; other site 572264010779 putative ligand binding site [chemical binding]; other site 572264010780 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 572264010781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264010782 dimer interface [polypeptide binding]; other site 572264010783 conserved gate region; other site 572264010784 putative PBP binding loops; other site 572264010785 ABC-ATPase subunit interface; other site 572264010786 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 572264010787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264010788 dimer interface [polypeptide binding]; other site 572264010789 conserved gate region; other site 572264010790 putative PBP binding loops; other site 572264010791 ABC-ATPase subunit interface; other site 572264010792 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 572264010793 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 572264010794 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 572264010795 homodimer interface [polypeptide binding]; other site 572264010796 maltodextrin glucosidase; Provisional; Region: PRK10785 572264010797 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 572264010798 active site 572264010799 homodimer interface [polypeptide binding]; other site 572264010800 catalytic site [active] 572264010801 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 572264010802 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 572264010803 Ca binding site [ion binding]; other site 572264010804 active site 572264010805 catalytic site [active] 572264010806 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 572264010807 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 572264010808 Walker A/P-loop; other site 572264010809 ATP binding site [chemical binding]; other site 572264010810 Q-loop/lid; other site 572264010811 ABC transporter signature motif; other site 572264010812 Walker B; other site 572264010813 D-loop; other site 572264010814 H-loop/switch region; other site 572264010815 TOBE domain; Region: TOBE_2; pfam08402 572264010816 hypothetical protein; Provisional; Region: PRK06720 572264010817 NAD(P) binding site [chemical binding]; other site 572264010818 RDD family; Region: RDD; pfam06271 572264010819 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 572264010820 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 572264010821 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 572264010822 Predicted ATPase [General function prediction only]; Region: COG3910 572264010823 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264010824 Walker A/P-loop; other site 572264010825 ATP binding site [chemical binding]; other site 572264010826 Q-loop/lid; other site 572264010827 ABC transporter signature motif; other site 572264010828 Walker B; other site 572264010829 D-loop; other site 572264010830 H-loop/switch region; other site 572264010831 putative acyltransferase; Provisional; Region: PRK05790 572264010832 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 572264010833 dimer interface [polypeptide binding]; other site 572264010834 active site 572264010835 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 572264010836 nudix motif; other site 572264010837 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 572264010838 hypothetical protein; Validated; Region: PRK07668 572264010839 hypothetical protein; Validated; Region: PRK07668 572264010840 Predicted transcriptional regulators [Transcription]; Region: COG1695 572264010841 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 572264010842 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 572264010843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572264010844 NAD(P) binding site [chemical binding]; other site 572264010845 active site 572264010846 YvrJ protein family; Region: YvrJ; pfam12841 572264010847 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 572264010848 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 572264010849 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 572264010850 Phosphotransferase enzyme family; Region: APH; pfam01636 572264010851 Predicted amidohydrolase [General function prediction only]; Region: COG0388 572264010852 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 572264010853 putative active site [active] 572264010854 catalytic triad [active] 572264010855 putative dimer interface [polypeptide binding]; other site 572264010856 transaminase; Reviewed; Region: PRK08068 572264010857 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572264010858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264010859 homodimer interface [polypeptide binding]; other site 572264010860 catalytic residue [active] 572264010861 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 572264010862 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 572264010863 dimer interface [polypeptide binding]; other site 572264010864 active site 572264010865 catalytic residue [active] 572264010866 metal binding site [ion binding]; metal-binding site 572264010867 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 572264010868 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 572264010869 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 572264010870 intersubunit interface [polypeptide binding]; other site 572264010871 active site 572264010872 Zn2+ binding site [ion binding]; other site 572264010873 ARD/ARD' family; Region: ARD; pfam03079 572264010874 Cupin domain; Region: Cupin_2; pfam07883 572264010875 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 572264010876 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 572264010877 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 572264010878 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572264010879 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572264010880 metal binding site [ion binding]; metal-binding site 572264010881 active site 572264010882 I-site; other site 572264010883 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 572264010884 dimer interface [polypeptide binding]; other site 572264010885 FMN binding site [chemical binding]; other site 572264010886 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 572264010887 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 572264010888 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 572264010889 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 572264010890 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 572264010891 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 572264010892 dimerization domain swap beta strand [polypeptide binding]; other site 572264010893 regulatory protein interface [polypeptide binding]; other site 572264010894 active site 572264010895 regulatory phosphorylation site [posttranslational modification]; other site 572264010896 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 572264010897 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 572264010898 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 572264010899 active site turn [active] 572264010900 phosphorylation site [posttranslational modification] 572264010901 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 572264010902 HPr interaction site; other site 572264010903 glycerol kinase (GK) interaction site [polypeptide binding]; other site 572264010904 active site 572264010905 phosphorylation site [posttranslational modification] 572264010906 transcriptional antiterminator BglG; Provisional; Region: PRK09772 572264010907 CAT RNA binding domain; Region: CAT_RBD; smart01061 572264010908 PRD domain; Region: PRD; pfam00874 572264010909 PRD domain; Region: PRD; pfam00874 572264010910 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 572264010911 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264010912 active site 572264010913 motif I; other site 572264010914 motif II; other site 572264010915 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264010916 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 572264010917 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 572264010918 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 572264010919 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 572264010920 active site 572264010921 trimer interface [polypeptide binding]; other site 572264010922 allosteric site; other site 572264010923 active site lid [active] 572264010924 hexamer (dimer of trimers) interface [polypeptide binding]; other site 572264010925 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 572264010926 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 572264010927 active site 572264010928 dimer interface [polypeptide binding]; other site 572264010929 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 572264010930 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572264010931 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 572264010932 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 572264010933 Domain of unknown function (DUF309); Region: DUF309; pfam03745 572264010934 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264010935 Coenzyme A binding pocket [chemical binding]; other site 572264010936 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 572264010937 active site 572264010938 Predicted secreted protein [Function unknown]; Region: COG4086 572264010939 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 572264010940 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 572264010941 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 572264010942 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 572264010943 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 572264010944 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 572264010945 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 572264010946 stage V sporulation protein AD; Validated; Region: PRK08304 572264010947 stage V sporulation protein AD; Provisional; Region: PRK12404 572264010948 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 572264010949 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 572264010950 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 572264010951 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 572264010952 Na2 binding site [ion binding]; other site 572264010953 putative substrate binding site 1 [chemical binding]; other site 572264010954 Na binding site 1 [ion binding]; other site 572264010955 putative substrate binding site 2 [chemical binding]; other site 572264010956 sporulation sigma factor SigF; Validated; Region: PRK05572 572264010957 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264010958 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 572264010959 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572264010960 DNA binding residues [nucleotide binding] 572264010961 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 572264010962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264010963 ATP binding site [chemical binding]; other site 572264010964 Mg2+ binding site [ion binding]; other site 572264010965 G-X-G motif; other site 572264010966 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 572264010967 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 572264010968 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 572264010969 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 572264010970 Predicted transcriptional regulators [Transcription]; Region: COG1725 572264010971 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572264010972 DNA-binding site [nucleotide binding]; DNA binding site 572264010973 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 572264010974 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 572264010975 Walker A/P-loop; other site 572264010976 ATP binding site [chemical binding]; other site 572264010977 Q-loop/lid; other site 572264010978 ABC transporter signature motif; other site 572264010979 Walker B; other site 572264010980 D-loop; other site 572264010981 H-loop/switch region; other site 572264010982 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 572264010983 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 572264010984 MarR family; Region: MarR; pfam01047 572264010985 MarR family; Region: MarR_2; cl17246 572264010986 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 572264010987 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 572264010988 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 572264010989 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 572264010990 oligomer interface [polypeptide binding]; other site 572264010991 metal binding site [ion binding]; metal-binding site 572264010992 metal binding site [ion binding]; metal-binding site 572264010993 putative Cl binding site [ion binding]; other site 572264010994 aspartate ring; other site 572264010995 basic sphincter; other site 572264010996 hydrophobic gate; other site 572264010997 periplasmic entrance; other site 572264010998 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 572264010999 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 572264011000 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 572264011001 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 572264011002 purine nucleoside phosphorylase; Provisional; Region: PRK08202 572264011003 phosphopentomutase; Provisional; Region: PRK05362 572264011004 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 572264011005 YtkA-like; Region: YtkA; pfam13115 572264011006 YtkA-like; Region: YtkA; pfam13115 572264011007 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 572264011008 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 572264011009 active site 572264011010 Int/Topo IB signature motif; other site 572264011011 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 572264011012 ferric uptake regulator; Provisional; Region: fur; PRK09462 572264011013 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 572264011014 metal binding site 2 [ion binding]; metal-binding site 572264011015 putative DNA binding helix; other site 572264011016 metal binding site 1 [ion binding]; metal-binding site 572264011017 dimer interface [polypeptide binding]; other site 572264011018 structural Zn2+ binding site [ion binding]; other site 572264011019 stage II sporulation protein M; Region: spo_II_M; TIGR02831 572264011020 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572264011021 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 572264011022 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 572264011023 dimer interface [polypeptide binding]; other site 572264011024 ADP-ribose binding site [chemical binding]; other site 572264011025 active site 572264011026 nudix motif; other site 572264011027 metal binding site [ion binding]; metal-binding site 572264011028 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 572264011029 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 572264011030 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 572264011031 active site 572264011032 catalytic tetrad [active] 572264011033 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 572264011034 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 572264011035 active site 572264011036 catalytic tetrad [active] 572264011037 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 572264011038 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 572264011039 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 572264011040 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 572264011041 putative active site [active] 572264011042 putative metal binding site [ion binding]; other site 572264011043 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 572264011044 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 572264011045 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 572264011046 Predicted permease [General function prediction only]; Region: COG2056 572264011047 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 572264011048 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 572264011049 Transcriptional regulators [Transcription]; Region: PurR; COG1609 572264011050 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 572264011051 DNA binding site [nucleotide binding] 572264011052 domain linker motif; other site 572264011053 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 572264011054 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264011055 Coenzyme A binding pocket [chemical binding]; other site 572264011056 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 572264011057 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 572264011058 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 572264011059 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 572264011060 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 572264011061 catalytic motif [active] 572264011062 Zn binding site [ion binding]; other site 572264011063 RibD C-terminal domain; Region: RibD_C; cl17279 572264011064 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 572264011065 Lumazine binding domain; Region: Lum_binding; pfam00677 572264011066 Lumazine binding domain; Region: Lum_binding; pfam00677 572264011067 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 572264011068 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 572264011069 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 572264011070 dimerization interface [polypeptide binding]; other site 572264011071 active site 572264011072 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 572264011073 homopentamer interface [polypeptide binding]; other site 572264011074 active site 572264011075 biotin synthase; Validated; Region: PRK06256 572264011076 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572264011077 FeS/SAM binding site; other site 572264011078 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 572264011079 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 572264011080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264011081 S-adenosylmethionine binding site [chemical binding]; other site 572264011082 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572264011083 TAP-like protein; Region: Abhydrolase_4; pfam08386 572264011084 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 572264011085 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 572264011086 substrate-cofactor binding pocket; other site 572264011087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264011088 catalytic residue [active] 572264011089 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 572264011090 AAA domain; Region: AAA_26; pfam13500 572264011091 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 572264011092 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 572264011093 inhibitor-cofactor binding pocket; inhibition site 572264011094 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264011095 catalytic residue [active] 572264011096 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 572264011097 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 572264011098 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 572264011099 active site 572264011100 metal binding site [ion binding]; metal-binding site 572264011101 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 572264011102 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 572264011103 active site 572264011104 catalytic triad [active] 572264011105 oxyanion hole [active] 572264011106 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264011107 dimerization interface [polypeptide binding]; other site 572264011108 putative DNA binding site [nucleotide binding]; other site 572264011109 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 572264011110 putative Zn2+ binding site [ion binding]; other site 572264011111 ornithine carbamoyltransferase; Provisional; Region: PRK00779 572264011112 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 572264011113 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 572264011114 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 572264011115 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 572264011116 inhibitor-cofactor binding pocket; inhibition site 572264011117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264011118 catalytic residue [active] 572264011119 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 572264011120 nucleotide binding site [chemical binding]; other site 572264011121 N-acetyl-L-glutamate binding site [chemical binding]; other site 572264011122 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 572264011123 heterotetramer interface [polypeptide binding]; other site 572264011124 active site pocket [active] 572264011125 cleavage site 572264011126 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 572264011127 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 572264011128 YqzH-like protein; Region: YqzH; pfam14164 572264011129 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 572264011130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572264011131 NAD(P) binding site [chemical binding]; other site 572264011132 active site 572264011133 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572264011134 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 572264011135 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 572264011136 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 572264011137 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 572264011138 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 572264011139 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 572264011140 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 572264011141 putative L-serine binding site [chemical binding]; other site 572264011142 ribonuclease Z; Region: RNase_Z; TIGR02651 572264011143 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 572264011144 DNA polymerase IV; Validated; Region: PRK01810 572264011145 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 572264011146 active site 572264011147 DNA binding site [nucleotide binding] 572264011148 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 572264011149 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 572264011150 peptidase T-like protein; Region: PepT-like; TIGR01883 572264011151 metal binding site [ion binding]; metal-binding site 572264011152 putative dimer interface [polypeptide binding]; other site 572264011153 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 572264011154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 572264011155 Protein of unknown function (DUF3894); Region: DUF3894; pfam13033 572264011156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 572264011157 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 572264011158 Predicted membrane protein [Function unknown]; Region: COG4129 572264011159 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 572264011160 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 572264011161 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 572264011162 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 572264011163 Walker A/P-loop; other site 572264011164 ATP binding site [chemical binding]; other site 572264011165 Q-loop/lid; other site 572264011166 ABC transporter signature motif; other site 572264011167 Walker B; other site 572264011168 D-loop; other site 572264011169 H-loop/switch region; other site 572264011170 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 572264011171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264011172 dimer interface [polypeptide binding]; other site 572264011173 conserved gate region; other site 572264011174 putative PBP binding loops; other site 572264011175 ABC-ATPase subunit interface; other site 572264011176 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 572264011177 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572264011178 substrate binding pocket [chemical binding]; other site 572264011179 membrane-bound complex binding site; other site 572264011180 hinge residues; other site 572264011181 Disulphide isomerase; Region: Disulph_isomer; pfam06491 572264011182 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 572264011183 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 572264011184 nudix motif; other site 572264011185 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 572264011186 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 572264011187 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 572264011188 E3 interaction surface; other site 572264011189 lipoyl attachment site [posttranslational modification]; other site 572264011190 e3 binding domain; Region: E3_binding; pfam02817 572264011191 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 572264011192 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 572264011193 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 572264011194 alpha subunit interface [polypeptide binding]; other site 572264011195 TPP binding site [chemical binding]; other site 572264011196 heterodimer interface [polypeptide binding]; other site 572264011197 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 572264011198 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 572264011199 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 572264011200 tetramer interface [polypeptide binding]; other site 572264011201 TPP-binding site [chemical binding]; other site 572264011202 heterodimer interface [polypeptide binding]; other site 572264011203 phosphorylation loop region [posttranslational modification] 572264011204 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 572264011205 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 572264011206 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572264011207 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 572264011208 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 572264011209 nucleotide binding site [chemical binding]; other site 572264011210 Acetokinase family; Region: Acetate_kinase; cl17229 572264011211 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 572264011212 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 572264011213 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 572264011214 NAD binding site [chemical binding]; other site 572264011215 Phe binding site; other site 572264011216 phosphate butyryltransferase; Validated; Region: PRK07742 572264011217 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 572264011218 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572264011219 putative active site [active] 572264011220 heme pocket [chemical binding]; other site 572264011221 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572264011222 putative active site [active] 572264011223 heme pocket [chemical binding]; other site 572264011224 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264011225 Walker A motif; other site 572264011226 ATP binding site [chemical binding]; other site 572264011227 Walker B motif; other site 572264011228 arginine finger; other site 572264011229 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 572264011230 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 572264011231 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 572264011232 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 572264011233 active site 572264011234 catalytic site [active] 572264011235 metal binding site [ion binding]; metal-binding site 572264011236 dimer interface [polypeptide binding]; other site 572264011237 YycC-like protein; Region: YycC; pfam14174 572264011238 conserved hypothetical integral membrane protein; Region: TIGR03766 572264011239 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 572264011240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264011241 active site 572264011242 phosphorylation site [posttranslational modification] 572264011243 intermolecular recognition site; other site 572264011244 dimerization interface [polypeptide binding]; other site 572264011245 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 572264011246 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 572264011247 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 572264011248 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 572264011249 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 572264011250 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 572264011251 Walker A/P-loop; other site 572264011252 ATP binding site [chemical binding]; other site 572264011253 Q-loop/lid; other site 572264011254 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 572264011255 ABC transporter signature motif; other site 572264011256 Walker B; other site 572264011257 D-loop; other site 572264011258 H-loop/switch region; other site 572264011259 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 572264011260 arginine repressor; Provisional; Region: PRK04280 572264011261 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 572264011262 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 572264011263 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572264011264 RNA binding surface [nucleotide binding]; other site 572264011265 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 572264011266 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 572264011267 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 572264011268 TPP-binding site; other site 572264011269 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 572264011270 PYR/PP interface [polypeptide binding]; other site 572264011271 dimer interface [polypeptide binding]; other site 572264011272 TPP binding site [chemical binding]; other site 572264011273 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 572264011274 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 572264011275 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 572264011276 substrate binding pocket [chemical binding]; other site 572264011277 chain length determination region; other site 572264011278 substrate-Mg2+ binding site; other site 572264011279 catalytic residues [active] 572264011280 aspartate-rich region 1; other site 572264011281 active site lid residues [active] 572264011282 aspartate-rich region 2; other site 572264011283 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 572264011284 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 572264011285 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 572264011286 generic binding surface II; other site 572264011287 generic binding surface I; other site 572264011288 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 572264011289 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 572264011290 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 572264011291 homodimer interface [polypeptide binding]; other site 572264011292 NADP binding site [chemical binding]; other site 572264011293 substrate binding site [chemical binding]; other site 572264011294 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 572264011295 putative RNA binding site [nucleotide binding]; other site 572264011296 Asp23 family; Region: Asp23; pfam03780 572264011297 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 572264011298 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 572264011299 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 572264011300 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 572264011301 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 572264011302 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 572264011303 carboxyltransferase (CT) interaction site; other site 572264011304 biotinylation site [posttranslational modification]; other site 572264011305 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 572264011306 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 572264011307 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 572264011308 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 572264011309 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 572264011310 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 572264011311 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 572264011312 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 572264011313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264011314 Walker A motif; other site 572264011315 ATP binding site [chemical binding]; other site 572264011316 Walker B motif; other site 572264011317 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 572264011318 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572264011319 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 572264011320 elongation factor P; Validated; Region: PRK00529 572264011321 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 572264011322 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 572264011323 RNA binding site [nucleotide binding]; other site 572264011324 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 572264011325 RNA binding site [nucleotide binding]; other site 572264011326 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 572264011327 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 572264011328 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 572264011329 active site 572264011330 Dehydroquinase class II; Region: DHquinase_II; pfam01220 572264011331 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 572264011332 trimer interface [polypeptide binding]; other site 572264011333 active site 572264011334 dimer interface [polypeptide binding]; other site 572264011335 Conserved membrane protein YqhR; Region: YqhR; pfam11085 572264011336 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 572264011337 CCC1-related family of proteins; Region: CCC1_like; cl00278 572264011338 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 572264011339 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 572264011340 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264011341 motif II; other site 572264011342 manganese transport transcriptional regulator; Provisional; Region: PRK03902 572264011343 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 572264011344 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 572264011345 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 572264011346 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572264011347 FeS/SAM binding site; other site 572264011348 Predicted transcriptional regulators [Transcription]; Region: COG1695 572264011349 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 572264011350 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 572264011351 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 572264011352 active site residue [active] 572264011353 Transcriptional regulators [Transcription]; Region: PurR; COG1609 572264011354 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 572264011355 DNA binding site [nucleotide binding] 572264011356 domain linker motif; other site 572264011357 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 572264011358 putative dimerization interface [polypeptide binding]; other site 572264011359 putative ligand binding site [chemical binding]; other site 572264011360 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264011361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264011362 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 572264011363 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 572264011364 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 572264011365 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 572264011366 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 572264011367 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 572264011368 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 572264011369 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 572264011370 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 572264011371 Walker A/P-loop; other site 572264011372 ATP binding site [chemical binding]; other site 572264011373 Q-loop/lid; other site 572264011374 ABC transporter signature motif; other site 572264011375 Walker B; other site 572264011376 D-loop; other site 572264011377 H-loop/switch region; other site 572264011378 Predicted transcriptional regulators [Transcription]; Region: COG1725 572264011379 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572264011380 DNA-binding site [nucleotide binding]; DNA binding site 572264011381 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 572264011382 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 572264011383 tetramer interface [polypeptide binding]; other site 572264011384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264011385 catalytic residue [active] 572264011386 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 572264011387 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 572264011388 tetramer interface [polypeptide binding]; other site 572264011389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264011390 catalytic residue [active] 572264011391 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 572264011392 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 572264011393 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 572264011394 DEAD-like helicases superfamily; Region: DEXDc; smart00487 572264011395 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572264011396 ATP binding site [chemical binding]; other site 572264011397 putative Mg++ binding site [ion binding]; other site 572264011398 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572264011399 nucleotide binding region [chemical binding]; other site 572264011400 ATP-binding site [chemical binding]; other site 572264011401 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 572264011402 YqzE-like protein; Region: YqzE; pfam14038 572264011403 shikimate kinase; Reviewed; Region: aroK; PRK00131 572264011404 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 572264011405 ADP binding site [chemical binding]; other site 572264011406 magnesium binding site [ion binding]; other site 572264011407 putative shikimate binding site; other site 572264011408 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 572264011409 ComG operon protein 7; Region: ComGG; pfam14173 572264011410 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 572264011411 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 572264011412 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 572264011413 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 572264011414 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 572264011415 Type II/IV secretion system protein; Region: T2SE; pfam00437 572264011416 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 572264011417 Walker A motif; other site 572264011418 ATP binding site [chemical binding]; other site 572264011419 Walker B motif; other site 572264011420 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264011421 putative DNA binding site [nucleotide binding]; other site 572264011422 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 572264011423 putative Zn2+ binding site [ion binding]; other site 572264011424 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 572264011425 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 572264011426 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 572264011427 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 572264011428 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 572264011429 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572264011430 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 572264011431 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 572264011432 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 572264011433 active site 572264011434 homodimer interface [polypeptide binding]; other site 572264011435 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 572264011436 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 572264011437 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 572264011438 substrate binding pocket [chemical binding]; other site 572264011439 dimer interface [polypeptide binding]; other site 572264011440 inhibitor binding site; inhibition site 572264011441 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 572264011442 B12 binding site [chemical binding]; other site 572264011443 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 572264011444 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 572264011445 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 572264011446 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 572264011447 FAD binding site [chemical binding]; other site 572264011448 cystathionine gamma-synthase; Reviewed; Region: PRK08247 572264011449 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 572264011450 homodimer interface [polypeptide binding]; other site 572264011451 substrate-cofactor binding pocket; other site 572264011452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264011453 catalytic residue [active] 572264011454 cystathionine beta-lyase; Provisional; Region: PRK08064 572264011455 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 572264011456 homodimer interface [polypeptide binding]; other site 572264011457 substrate-cofactor binding pocket; other site 572264011458 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264011459 catalytic residue [active] 572264011460 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264011461 dimerization interface [polypeptide binding]; other site 572264011462 putative DNA binding site [nucleotide binding]; other site 572264011463 putative Zn2+ binding site [ion binding]; other site 572264011464 Uncharacterized conserved protein [Function unknown]; Region: COG1565 572264011465 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 572264011466 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 572264011467 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 572264011468 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 572264011469 nucleotide binding site [chemical binding]; other site 572264011470 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 572264011471 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 572264011472 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 572264011473 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 572264011474 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 572264011475 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 572264011476 active site 572264011477 Substrate binding site; other site 572264011478 Mg++ binding site; other site 572264011479 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 572264011480 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 572264011481 active site 572264011482 metal binding site [ion binding]; metal-binding site 572264011483 substrate binding site [chemical binding]; other site 572264011484 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 572264011485 PhoU domain; Region: PhoU; pfam01895 572264011486 PhoU domain; Region: PhoU; pfam01895 572264011487 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 572264011488 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 572264011489 Walker A/P-loop; other site 572264011490 ATP binding site [chemical binding]; other site 572264011491 Q-loop/lid; other site 572264011492 ABC transporter signature motif; other site 572264011493 Walker B; other site 572264011494 D-loop; other site 572264011495 H-loop/switch region; other site 572264011496 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 572264011497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264011498 dimer interface [polypeptide binding]; other site 572264011499 conserved gate region; other site 572264011500 putative PBP binding loops; other site 572264011501 ABC-ATPase subunit interface; other site 572264011502 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 572264011503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264011504 dimer interface [polypeptide binding]; other site 572264011505 conserved gate region; other site 572264011506 putative PBP binding loops; other site 572264011507 ABC-ATPase subunit interface; other site 572264011508 PBP superfamily domain; Region: PBP_like_2; cl17296 572264011509 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 572264011510 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 572264011511 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572264011512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264011513 putative substrate translocation pore; other site 572264011514 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264011515 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 572264011516 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 572264011517 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 572264011518 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 572264011519 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 572264011520 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 572264011521 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 572264011522 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 572264011523 metal binding site 2 [ion binding]; metal-binding site 572264011524 putative DNA binding helix; other site 572264011525 metal binding site 1 [ion binding]; metal-binding site 572264011526 dimer interface [polypeptide binding]; other site 572264011527 structural Zn2+ binding site [ion binding]; other site 572264011528 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 572264011529 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572264011530 ABC-ATPase subunit interface; other site 572264011531 dimer interface [polypeptide binding]; other site 572264011532 putative PBP binding regions; other site 572264011533 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 572264011534 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 572264011535 Uncharacterized conserved protein [Function unknown]; Region: COG1284 572264011536 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 572264011537 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 572264011538 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 572264011539 endonuclease IV; Provisional; Region: PRK01060 572264011540 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 572264011541 AP (apurinic/apyrimidinic) site pocket; other site 572264011542 DNA interaction; other site 572264011543 Metal-binding active site; metal-binding site 572264011544 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 572264011545 DEAD-like helicases superfamily; Region: DEXDc; smart00487 572264011546 ATP binding site [chemical binding]; other site 572264011547 Mg++ binding site [ion binding]; other site 572264011548 motif III; other site 572264011549 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572264011550 nucleotide binding region [chemical binding]; other site 572264011551 ATP-binding site [chemical binding]; other site 572264011552 YqfQ-like protein; Region: YqfQ; pfam14181 572264011553 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 572264011554 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 572264011555 Uncharacterized conserved protein [Function unknown]; Region: COG0327 572264011556 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 572264011557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 572264011558 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 572264011559 Uncharacterized conserved protein [Function unknown]; Region: COG0327 572264011560 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 572264011561 Family of unknown function (DUF633); Region: DUF633; pfam04816 572264011562 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 572264011563 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 572264011564 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 572264011565 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 572264011566 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 572264011567 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264011568 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 572264011569 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572264011570 DNA binding residues [nucleotide binding] 572264011571 DNA primase; Validated; Region: dnaG; PRK05667 572264011572 CHC2 zinc finger; Region: zf-CHC2; pfam01807 572264011573 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 572264011574 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 572264011575 active site 572264011576 metal binding site [ion binding]; metal-binding site 572264011577 interdomain interaction site; other site 572264011578 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 572264011579 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 572264011580 PEP synthetase regulatory protein; Provisional; Region: PRK05339 572264011581 HTH domain; Region: HTH_11; pfam08279 572264011582 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 572264011583 FOG: CBS domain [General function prediction only]; Region: COG0517 572264011584 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 572264011585 Recombination protein O N terminal; Region: RecO_N; pfam11967 572264011586 Recombination protein O C terminal; Region: RecO_C; pfam02565 572264011587 YqzL-like protein; Region: YqzL; pfam14006 572264011588 GTPase Era; Reviewed; Region: era; PRK00089 572264011589 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 572264011590 G1 box; other site 572264011591 GTP/Mg2+ binding site [chemical binding]; other site 572264011592 Switch I region; other site 572264011593 G2 box; other site 572264011594 Switch II region; other site 572264011595 G3 box; other site 572264011596 G4 box; other site 572264011597 G5 box; other site 572264011598 KH domain; Region: KH_2; pfam07650 572264011599 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 572264011600 active site 572264011601 catalytic motif [active] 572264011602 Zn binding site [ion binding]; other site 572264011603 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 572264011604 metal-binding heat shock protein; Provisional; Region: PRK00016 572264011605 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 572264011606 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 572264011607 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572264011608 Zn2+ binding site [ion binding]; other site 572264011609 Mg2+ binding site [ion binding]; other site 572264011610 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 572264011611 PhoH-like protein; Region: PhoH; pfam02562 572264011612 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 572264011613 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 572264011614 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 572264011615 Yqey-like protein; Region: YqeY; pfam09424 572264011616 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 572264011617 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 572264011618 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 572264011619 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572264011620 FeS/SAM binding site; other site 572264011621 TRAM domain; Region: TRAM; cl01282 572264011622 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 572264011623 RNA methyltransferase, RsmE family; Region: TIGR00046 572264011624 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 572264011625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264011626 S-adenosylmethionine binding site [chemical binding]; other site 572264011627 chaperone protein DnaJ; Provisional; Region: PRK14280 572264011628 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 572264011629 HSP70 interaction site [polypeptide binding]; other site 572264011630 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 572264011631 substrate binding site [polypeptide binding]; other site 572264011632 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 572264011633 Zn binding sites [ion binding]; other site 572264011634 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 572264011635 dimer interface [polypeptide binding]; other site 572264011636 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 572264011637 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 572264011638 nucleotide binding site [chemical binding]; other site 572264011639 NEF interaction site [polypeptide binding]; other site 572264011640 SBD interface [polypeptide binding]; other site 572264011641 GrpE; Region: GrpE; pfam01025 572264011642 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 572264011643 dimer interface [polypeptide binding]; other site 572264011644 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 572264011645 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 572264011646 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 572264011647 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 572264011648 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572264011649 FeS/SAM binding site; other site 572264011650 HemN C-terminal domain; Region: HemN_C; pfam06969 572264011651 Predicted transcriptional regulators [Transcription]; Region: COG1733 572264011652 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 572264011653 GTP-binding protein LepA; Provisional; Region: PRK05433 572264011654 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 572264011655 G1 box; other site 572264011656 putative GEF interaction site [polypeptide binding]; other site 572264011657 GTP/Mg2+ binding site [chemical binding]; other site 572264011658 Switch I region; other site 572264011659 G2 box; other site 572264011660 G3 box; other site 572264011661 Switch II region; other site 572264011662 G4 box; other site 572264011663 G5 box; other site 572264011664 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 572264011665 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 572264011666 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 572264011667 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 572264011668 germination protease; Provisional; Region: PRK02858 572264011669 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 572264011670 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 572264011671 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 572264011672 YqzM-like protein; Region: YqzM; pfam14141 572264011673 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 572264011674 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 572264011675 Competence protein; Region: Competence; pfam03772 572264011676 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572264011677 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 572264011678 catalytic motif [active] 572264011679 Zn binding site [ion binding]; other site 572264011680 SLBB domain; Region: SLBB; pfam10531 572264011681 comEA protein; Region: comE; TIGR01259 572264011682 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 572264011683 late competence protein ComER; Validated; Region: PRK07680 572264011684 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 572264011685 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 572264011686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264011687 S-adenosylmethionine binding site [chemical binding]; other site 572264011688 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 572264011689 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572264011690 Zn2+ binding site [ion binding]; other site 572264011691 Mg2+ binding site [ion binding]; other site 572264011692 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 572264011693 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 572264011694 active site 572264011695 (T/H)XGH motif; other site 572264011696 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 572264011697 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 572264011698 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 572264011699 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 572264011700 shikimate binding site; other site 572264011701 NAD(P) binding site [chemical binding]; other site 572264011702 GTPase YqeH; Provisional; Region: PRK13796 572264011703 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 572264011704 GTP/Mg2+ binding site [chemical binding]; other site 572264011705 G4 box; other site 572264011706 G5 box; other site 572264011707 G1 box; other site 572264011708 Switch I region; other site 572264011709 G2 box; other site 572264011710 G3 box; other site 572264011711 Switch II region; other site 572264011712 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 572264011713 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264011714 active site 572264011715 motif I; other site 572264011716 motif II; other site 572264011717 Sporulation inhibitor A; Region: Sda; pfam08970 572264011718 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 572264011719 sporulation sigma factor SigK; Reviewed; Region: PRK05803 572264011720 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264011721 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572264011722 DNA binding residues [nucleotide binding] 572264011723 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 572264011724 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 572264011725 dimer interface [polypeptide binding]; other site 572264011726 FMN binding site [chemical binding]; other site 572264011727 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 572264011728 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 572264011729 synthetase active site [active] 572264011730 NTP binding site [chemical binding]; other site 572264011731 metal binding site [ion binding]; metal-binding site 572264011732 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 572264011733 dimer interface [polypeptide binding]; other site 572264011734 Alkaline phosphatase homologues; Region: alkPPc; smart00098 572264011735 active site 572264011736 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 572264011737 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264011738 Coenzyme A binding pocket [chemical binding]; other site 572264011739 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 572264011740 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 572264011741 CHAT domain; Region: CHAT; cl17868 572264011742 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 572264011743 catalytic core [active] 572264011744 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 572264011745 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 572264011746 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 572264011747 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 572264011748 putative active site [active] 572264011749 catalytic triad [active] 572264011750 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 572264011751 putative integrin binding motif; other site 572264011752 PA/protease domain interface [polypeptide binding]; other site 572264011753 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 572264011754 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 572264011755 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 572264011756 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 572264011757 cofactor binding site; other site 572264011758 metal binding site [ion binding]; metal-binding site 572264011759 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 572264011760 aromatic arch; other site 572264011761 DCoH dimer interaction site [polypeptide binding]; other site 572264011762 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 572264011763 DCoH tetramer interaction site [polypeptide binding]; other site 572264011764 substrate binding site [chemical binding]; other site 572264011765 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 572264011766 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 572264011767 putative metal binding site [ion binding]; other site 572264011768 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 572264011769 active site 572264011770 metal binding site [ion binding]; metal-binding site 572264011771 Predicted membrane protein [Function unknown]; Region: COG2259 572264011772 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 572264011773 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264011774 non-specific DNA binding site [nucleotide binding]; other site 572264011775 salt bridge; other site 572264011776 sequence-specific DNA binding site [nucleotide binding]; other site 572264011777 Cupin domain; Region: Cupin_2; pfam07883 572264011778 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 572264011779 active site 2 [active] 572264011780 active site 1 [active] 572264011781 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264011782 Coenzyme A binding pocket [chemical binding]; other site 572264011783 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572264011784 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 572264011785 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 572264011786 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 572264011787 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 572264011788 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 572264011789 Walker A/P-loop; other site 572264011790 ATP binding site [chemical binding]; other site 572264011791 Q-loop/lid; other site 572264011792 ABC transporter signature motif; other site 572264011793 Walker B; other site 572264011794 D-loop; other site 572264011795 H-loop/switch region; other site 572264011796 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 572264011797 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572264011798 ABC-ATPase subunit interface; other site 572264011799 dimer interface [polypeptide binding]; other site 572264011800 putative PBP binding regions; other site 572264011801 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 572264011802 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 572264011803 intersubunit interface [polypeptide binding]; other site 572264011804 YrhC-like protein; Region: YrhC; pfam14143 572264011805 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 572264011806 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 572264011807 putative catalytic cysteine [active] 572264011808 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 572264011809 putative active site [active] 572264011810 metal binding site [ion binding]; metal-binding site 572264011811 cystathionine beta-lyase; Provisional; Region: PRK07671 572264011812 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 572264011813 homodimer interface [polypeptide binding]; other site 572264011814 substrate-cofactor binding pocket; other site 572264011815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264011816 catalytic residue [active] 572264011817 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 572264011818 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 572264011819 dimer interface [polypeptide binding]; other site 572264011820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264011821 catalytic residue [active] 572264011822 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 572264011823 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 572264011824 Methyltransferase domain; Region: Methyltransf_23; pfam13489 572264011825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264011826 S-adenosylmethionine binding site [chemical binding]; other site 572264011827 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 572264011828 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 572264011829 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 572264011830 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 572264011831 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572264011832 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 572264011833 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 572264011834 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 572264011835 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 572264011836 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 572264011837 ATP-binding site [chemical binding]; other site 572264011838 Sugar specificity; other site 572264011839 Pyrimidine base specificity; other site 572264011840 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 572264011841 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 572264011842 Peptidase family U32; Region: Peptidase_U32; pfam01136 572264011843 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 572264011844 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 572264011845 Peptidase family U32; Region: Peptidase_U32; pfam01136 572264011846 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 572264011847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264011848 S-adenosylmethionine binding site [chemical binding]; other site 572264011849 YceG-like family; Region: YceG; pfam02618 572264011850 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 572264011851 dimerization interface [polypeptide binding]; other site 572264011852 hypothetical protein; Provisional; Region: PRK13678 572264011853 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 572264011854 hypothetical protein; Provisional; Region: PRK05473 572264011855 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 572264011856 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 572264011857 motif 1; other site 572264011858 active site 572264011859 motif 2; other site 572264011860 motif 3; other site 572264011861 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 572264011862 DHHA1 domain; Region: DHHA1; pfam02272 572264011863 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 572264011864 Domain of unknown function DUF20; Region: UPF0118; pfam01594 572264011865 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 572264011866 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 572264011867 AAA domain; Region: AAA_30; pfam13604 572264011868 Family description; Region: UvrD_C_2; pfam13538 572264011869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264011870 TPR motif; other site 572264011871 TPR repeat; Region: TPR_11; pfam13414 572264011872 binding surface 572264011873 TPR repeat; Region: TPR_11; pfam13414 572264011874 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264011875 binding surface 572264011876 TPR motif; other site 572264011877 TPR repeat; Region: TPR_11; pfam13414 572264011878 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 572264011879 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 572264011880 Ligand Binding Site [chemical binding]; other site 572264011881 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 572264011882 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 572264011883 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572264011884 catalytic residue [active] 572264011885 Predicted transcriptional regulator [Transcription]; Region: COG1959 572264011886 Transcriptional regulator; Region: Rrf2; pfam02082 572264011887 recombination factor protein RarA; Reviewed; Region: PRK13342 572264011888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264011889 Walker A motif; other site 572264011890 ATP binding site [chemical binding]; other site 572264011891 Walker B motif; other site 572264011892 arginine finger; other site 572264011893 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 572264011894 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 572264011895 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 572264011896 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 572264011897 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 572264011898 putative ATP binding site [chemical binding]; other site 572264011899 putative substrate interface [chemical binding]; other site 572264011900 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 572264011901 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 572264011902 dimer interface [polypeptide binding]; other site 572264011903 anticodon binding site; other site 572264011904 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 572264011905 homodimer interface [polypeptide binding]; other site 572264011906 motif 1; other site 572264011907 active site 572264011908 motif 2; other site 572264011909 GAD domain; Region: GAD; pfam02938 572264011910 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 572264011911 motif 3; other site 572264011912 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 572264011913 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 572264011914 dimer interface [polypeptide binding]; other site 572264011915 motif 1; other site 572264011916 active site 572264011917 motif 2; other site 572264011918 motif 3; other site 572264011919 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 572264011920 anticodon binding site; other site 572264011921 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 572264011922 putative active site [active] 572264011923 dimerization interface [polypeptide binding]; other site 572264011924 putative tRNAtyr binding site [nucleotide binding]; other site 572264011925 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 572264011926 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572264011927 Zn2+ binding site [ion binding]; other site 572264011928 Mg2+ binding site [ion binding]; other site 572264011929 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 572264011930 synthetase active site [active] 572264011931 NTP binding site [chemical binding]; other site 572264011932 metal binding site [ion binding]; metal-binding site 572264011933 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 572264011934 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 572264011935 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572264011936 active site 572264011937 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 572264011938 DHH family; Region: DHH; pfam01368 572264011939 DHHA1 domain; Region: DHHA1; pfam02272 572264011940 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 572264011941 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 572264011942 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 572264011943 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 572264011944 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 572264011945 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 572264011946 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 572264011947 Protein export membrane protein; Region: SecD_SecF; pfam02355 572264011948 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 572264011949 stage V sporulation protein B; Region: spore_V_B; TIGR02900 572264011950 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 572264011951 Predicted membrane protein [Function unknown]; Region: COG2323 572264011952 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 572264011953 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 572264011954 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 572264011955 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 572264011956 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 572264011957 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 572264011958 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 572264011959 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 572264011960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264011961 Walker A motif; other site 572264011962 ATP binding site [chemical binding]; other site 572264011963 Walker B motif; other site 572264011964 arginine finger; other site 572264011965 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 572264011966 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 572264011967 RuvA N terminal domain; Region: RuvA_N; pfam01330 572264011968 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 572264011969 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 572264011970 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 572264011971 putative ligand binding residues [chemical binding]; other site 572264011972 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 572264011973 BofC C-terminal domain; Region: BofC_C; pfam08955 572264011974 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 572264011975 EamA-like transporter family; Region: EamA; pfam00892 572264011976 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 572264011977 EamA-like transporter family; Region: EamA; pfam00892 572264011978 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264011979 dimerization interface [polypeptide binding]; other site 572264011980 putative DNA binding site [nucleotide binding]; other site 572264011981 putative Zn2+ binding site [ion binding]; other site 572264011982 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 572264011983 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 572264011984 quinolinate synthetase; Provisional; Region: PRK09375 572264011985 L-aspartate oxidase; Provisional; Region: PRK08071 572264011986 L-aspartate oxidase; Provisional; Region: PRK06175 572264011987 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 572264011988 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 572264011989 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 572264011990 dimerization interface [polypeptide binding]; other site 572264011991 active site 572264011992 cysteine desulfurase; Provisional; Region: PRK02948 572264011993 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 572264011994 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572264011995 catalytic residue [active] 572264011996 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 572264011997 HTH domain; Region: HTH_11; pfam08279 572264011998 3H domain; Region: 3H; pfam02829 572264011999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 572264012000 MOSC domain; Region: MOSC; pfam03473 572264012001 3-alpha domain; Region: 3-alpha; pfam03475 572264012002 prephenate dehydratase; Provisional; Region: PRK11898 572264012003 Prephenate dehydratase; Region: PDT; pfam00800 572264012004 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 572264012005 putative L-Phe binding site [chemical binding]; other site 572264012006 FtsX-like permease family; Region: FtsX; pfam02687 572264012007 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 572264012008 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 572264012009 FtsX-like permease family; Region: FtsX; pfam02687 572264012010 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572264012011 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572264012012 Walker A/P-loop; other site 572264012013 ATP binding site [chemical binding]; other site 572264012014 Q-loop/lid; other site 572264012015 ABC transporter signature motif; other site 572264012016 Walker B; other site 572264012017 D-loop; other site 572264012018 H-loop/switch region; other site 572264012019 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264012020 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 572264012021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264012022 ATP binding site [chemical binding]; other site 572264012023 Mg2+ binding site [ion binding]; other site 572264012024 G-X-G motif; other site 572264012025 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264012026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264012027 active site 572264012028 phosphorylation site [posttranslational modification] 572264012029 intermolecular recognition site; other site 572264012030 dimerization interface [polypeptide binding]; other site 572264012031 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264012032 DNA binding site [nucleotide binding] 572264012033 GTPase CgtA; Reviewed; Region: obgE; PRK12297 572264012034 GTP1/OBG; Region: GTP1_OBG; pfam01018 572264012035 Obg GTPase; Region: Obg; cd01898 572264012036 G1 box; other site 572264012037 GTP/Mg2+ binding site [chemical binding]; other site 572264012038 Switch I region; other site 572264012039 G2 box; other site 572264012040 G3 box; other site 572264012041 Switch II region; other site 572264012042 G4 box; other site 572264012043 G5 box; other site 572264012044 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 572264012045 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 572264012046 hypothetical protein; Provisional; Region: PRK14553 572264012047 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 572264012048 Ribosomal protein L21 leader 572264012049 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 572264012050 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 572264012051 homodimer interface [polypeptide binding]; other site 572264012052 oligonucleotide binding site [chemical binding]; other site 572264012053 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 572264012054 Peptidase family M50; Region: Peptidase_M50; pfam02163 572264012055 active site 572264012056 putative substrate binding region [chemical binding]; other site 572264012057 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 572264012058 Peptidase family M23; Region: Peptidase_M23; pfam01551 572264012059 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 572264012060 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 572264012061 Switch I; other site 572264012062 Switch II; other site 572264012063 septum formation inhibitor; Reviewed; Region: minC; PRK00513 572264012064 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 572264012065 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 572264012066 rod shape-determining protein MreC; Provisional; Region: PRK13922 572264012067 rod shape-determining protein MreC; Region: MreC; pfam04085 572264012068 rod shape-determining protein MreB; Provisional; Region: PRK13927 572264012069 MreB and similar proteins; Region: MreB_like; cd10225 572264012070 nucleotide binding site [chemical binding]; other site 572264012071 Mg binding site [ion binding]; other site 572264012072 putative protofilament interaction site [polypeptide binding]; other site 572264012073 RodZ interaction site [polypeptide binding]; other site 572264012074 hypothetical protein; Reviewed; Region: PRK00024 572264012075 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 572264012076 MPN+ (JAMM) motif; other site 572264012077 Zinc-binding site [ion binding]; other site 572264012078 Maf-like protein; Region: Maf; pfam02545 572264012079 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 572264012080 active site 572264012081 dimer interface [polypeptide binding]; other site 572264012082 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 572264012083 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 572264012084 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 572264012085 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 572264012086 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572264012087 active site 572264012088 HIGH motif; other site 572264012089 nucleotide binding site [chemical binding]; other site 572264012090 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 572264012091 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 572264012092 active site 572264012093 KMSKS motif; other site 572264012094 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 572264012095 tRNA binding surface [nucleotide binding]; other site 572264012096 anticodon binding site; other site 572264012097 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 572264012098 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 572264012099 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 572264012100 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 572264012101 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 572264012102 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 572264012103 inhibitor-cofactor binding pocket; inhibition site 572264012104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264012105 catalytic residue [active] 572264012106 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 572264012107 dimer interface [polypeptide binding]; other site 572264012108 active site 572264012109 Schiff base residues; other site 572264012110 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 572264012111 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 572264012112 active site 572264012113 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 572264012114 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 572264012115 domain interfaces; other site 572264012116 active site 572264012117 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 572264012118 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 572264012119 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 572264012120 tRNA; other site 572264012121 putative tRNA binding site [nucleotide binding]; other site 572264012122 putative NADP binding site [chemical binding]; other site 572264012123 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 572264012124 Transcriptional regulators [Transcription]; Region: MarR; COG1846 572264012125 MarR family; Region: MarR; pfam01047 572264012126 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 572264012127 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 572264012128 G1 box; other site 572264012129 GTP/Mg2+ binding site [chemical binding]; other site 572264012130 Switch I region; other site 572264012131 G2 box; other site 572264012132 G3 box; other site 572264012133 Switch II region; other site 572264012134 G4 box; other site 572264012135 G5 box; other site 572264012136 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 572264012137 Found in ATP-dependent protease La (LON); Region: LON; smart00464 572264012138 Found in ATP-dependent protease La (LON); Region: LON; smart00464 572264012139 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264012140 Walker A motif; other site 572264012141 ATP binding site [chemical binding]; other site 572264012142 Walker B motif; other site 572264012143 arginine finger; other site 572264012144 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 572264012145 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 572264012146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264012147 Walker A motif; other site 572264012148 ATP binding site [chemical binding]; other site 572264012149 Walker B motif; other site 572264012150 arginine finger; other site 572264012151 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 572264012152 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 572264012153 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 572264012154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264012155 Walker A motif; other site 572264012156 ATP binding site [chemical binding]; other site 572264012157 Walker B motif; other site 572264012158 arginine finger; other site 572264012159 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 572264012160 trigger factor; Provisional; Region: tig; PRK01490 572264012161 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 572264012162 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 572264012163 Protein of unknown function (DUF3257); Region: DUF3257; pfam11645 572264012164 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 572264012165 pentamer interface [polypeptide binding]; other site 572264012166 dodecaamer interface [polypeptide binding]; other site 572264012167 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 572264012168 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 572264012169 active site 572264012170 metal binding site [ion binding]; metal-binding site 572264012171 homotetramer interface [polypeptide binding]; other site 572264012172 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 572264012173 active site 572264012174 dimerization interface [polypeptide binding]; other site 572264012175 ribonuclease PH; Reviewed; Region: rph; PRK00173 572264012176 Ribonuclease PH; Region: RNase_PH_bact; cd11362 572264012177 hexamer interface [polypeptide binding]; other site 572264012178 active site 572264012179 Sporulation and spore germination; Region: Germane; pfam10646 572264012180 Spore germination protein [General function prediction only]; Region: COG5401 572264012181 Sporulation and spore germination; Region: Germane; pfam10646 572264012182 glutamate racemase; Provisional; Region: PRK00865 572264012183 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 572264012184 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 572264012185 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 572264012186 potential catalytic triad [active] 572264012187 conserved cys residue [active] 572264012188 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264012189 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264012190 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 572264012191 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 572264012192 potential catalytic triad [active] 572264012193 conserved cys residue [active] 572264012194 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 572264012195 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572264012196 DNA binding residues [nucleotide binding] 572264012197 dimerization interface [polypeptide binding]; other site 572264012198 putative uracil/xanthine transporter; Provisional; Region: PRK11412 572264012199 putative deaminase; Validated; Region: PRK06846 572264012200 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 572264012201 active site 572264012202 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 572264012203 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 572264012204 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264012205 non-specific DNA binding site [nucleotide binding]; other site 572264012206 salt bridge; other site 572264012207 sequence-specific DNA binding site [nucleotide binding]; other site 572264012208 Cupin domain; Region: Cupin_2; pfam07883 572264012209 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 572264012210 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 572264012211 amphipathic channel; other site 572264012212 Asn-Pro-Ala signature motifs; other site 572264012213 Probable transposase; Region: OrfB_IS605; pfam01385 572264012214 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 572264012215 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 572264012216 Predicted transcriptional regulator [Transcription]; Region: COG1959 572264012217 Transcriptional regulator; Region: Rrf2; pfam02082 572264012218 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 572264012219 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 572264012220 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264012221 Walker A/P-loop; other site 572264012222 ATP binding site [chemical binding]; other site 572264012223 Q-loop/lid; other site 572264012224 ABC transporter signature motif; other site 572264012225 Walker B; other site 572264012226 D-loop; other site 572264012227 H-loop/switch region; other site 572264012228 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 572264012229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264012230 active site 572264012231 motif I; other site 572264012232 motif II; other site 572264012233 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 572264012234 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 572264012235 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 572264012236 ligand binding site [chemical binding]; other site 572264012237 flagellar motor protein MotA; Validated; Region: PRK08124 572264012238 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 572264012239 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 572264012240 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 572264012241 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 572264012242 active site 572264012243 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 572264012244 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 572264012245 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 572264012246 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 572264012247 L-aspartate oxidase; Provisional; Region: PRK06175 572264012248 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 572264012249 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 572264012250 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 572264012251 putative Iron-sulfur protein interface [polypeptide binding]; other site 572264012252 proximal heme binding site [chemical binding]; other site 572264012253 distal heme binding site [chemical binding]; other site 572264012254 putative dimer interface [polypeptide binding]; other site 572264012255 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 572264012256 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 572264012257 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 572264012258 GIY-YIG motif/motif A; other site 572264012259 active site 572264012260 catalytic site [active] 572264012261 putative DNA binding site [nucleotide binding]; other site 572264012262 metal binding site [ion binding]; metal-binding site 572264012263 UvrB/uvrC motif; Region: UVR; pfam02151 572264012264 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 572264012265 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 572264012266 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 572264012267 catalytic residues [active] 572264012268 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 572264012269 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 572264012270 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 572264012271 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 572264012272 Ligand binding site [chemical binding]; other site 572264012273 Electron transfer flavoprotein domain; Region: ETF; pfam01012 572264012274 enoyl-CoA hydratase; Provisional; Region: PRK07658 572264012275 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572264012276 substrate binding site [chemical binding]; other site 572264012277 oxyanion hole (OAH) forming residues; other site 572264012278 trimer interface [polypeptide binding]; other site 572264012279 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 572264012280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264012281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264012282 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 572264012283 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 572264012284 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 572264012285 acyl-activating enzyme (AAE) consensus motif; other site 572264012286 putative AMP binding site [chemical binding]; other site 572264012287 putative active site [active] 572264012288 putative CoA binding site [chemical binding]; other site 572264012289 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 572264012290 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 572264012291 siderophore binding site; other site 572264012292 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 572264012293 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572264012294 ABC-ATPase subunit interface; other site 572264012295 dimer interface [polypeptide binding]; other site 572264012296 putative PBP binding regions; other site 572264012297 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572264012298 ABC-ATPase subunit interface; other site 572264012299 dimer interface [polypeptide binding]; other site 572264012300 putative PBP binding regions; other site 572264012301 DinB family; Region: DinB; pfam05163 572264012302 DinB superfamily; Region: DinB_2; pfam12867 572264012303 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 572264012304 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 572264012305 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 572264012306 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 572264012307 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 572264012308 Walker A/P-loop; other site 572264012309 ATP binding site [chemical binding]; other site 572264012310 Q-loop/lid; other site 572264012311 ABC transporter signature motif; other site 572264012312 Walker B; other site 572264012313 D-loop; other site 572264012314 H-loop/switch region; other site 572264012315 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264012316 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264012317 dimer interface [polypeptide binding]; other site 572264012318 phosphorylation site [posttranslational modification] 572264012319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264012320 ATP binding site [chemical binding]; other site 572264012321 Mg2+ binding site [ion binding]; other site 572264012322 G-X-G motif; other site 572264012323 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264012324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264012325 active site 572264012326 phosphorylation site [posttranslational modification] 572264012327 intermolecular recognition site; other site 572264012328 dimerization interface [polypeptide binding]; other site 572264012329 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264012330 DNA binding site [nucleotide binding] 572264012331 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 572264012332 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 572264012333 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 572264012334 putative RNA binding site [nucleotide binding]; other site 572264012335 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 572264012336 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 572264012337 Neurotransmitter-gated ion-channel transmembrane region; Region: Neur_chan_memb; pfam02932 572264012338 TrkA-N domain; Region: TrkA_N; pfam02254 572264012339 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 572264012340 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 572264012341 active site 572264012342 catalytic site [active] 572264012343 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 572264012344 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 572264012345 Walker A/P-loop; other site 572264012346 ATP binding site [chemical binding]; other site 572264012347 Q-loop/lid; other site 572264012348 ABC transporter signature motif; other site 572264012349 Walker B; other site 572264012350 D-loop; other site 572264012351 H-loop/switch region; other site 572264012352 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 572264012353 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572264012354 ABC-ATPase subunit interface; other site 572264012355 dimer interface [polypeptide binding]; other site 572264012356 putative PBP binding regions; other site 572264012357 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 572264012358 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 572264012359 intersubunit interface [polypeptide binding]; other site 572264012360 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 572264012361 heme-binding site [chemical binding]; other site 572264012362 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 572264012363 heme-binding site [chemical binding]; other site 572264012364 Repeat of unknown function (DUF1388); Region: DUF1388; pfam07142 572264012365 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 572264012366 heme-binding site [chemical binding]; other site 572264012367 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 572264012368 heme-binding site [chemical binding]; other site 572264012369 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 572264012370 heme-binding site [chemical binding]; other site 572264012371 heme uptake protein IsdC; Region: IsdC; TIGR03656 572264012372 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 572264012373 heme-binding site [chemical binding]; other site 572264012374 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 572264012375 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 572264012376 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 572264012377 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572264012378 RNA binding surface [nucleotide binding]; other site 572264012379 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 572264012380 probable active site [active] 572264012381 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 572264012382 MutS domain III; Region: MutS_III; pfam05192 572264012383 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 572264012384 Walker A/P-loop; other site 572264012385 ATP binding site [chemical binding]; other site 572264012386 Q-loop/lid; other site 572264012387 ABC transporter signature motif; other site 572264012388 Walker B; other site 572264012389 D-loop; other site 572264012390 H-loop/switch region; other site 572264012391 Smr domain; Region: Smr; pfam01713 572264012392 hypothetical protein; Provisional; Region: PRK08609 572264012393 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 572264012394 active site 572264012395 primer binding site [nucleotide binding]; other site 572264012396 NTP binding site [chemical binding]; other site 572264012397 metal binding triad [ion binding]; metal-binding site 572264012398 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 572264012399 active site 572264012400 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 572264012401 Colicin V production protein; Region: Colicin_V; pfam02674 572264012402 cell division protein ZapA; Provisional; Region: PRK14126 572264012403 ribonuclease HIII; Provisional; Region: PRK00996 572264012404 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 572264012405 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 572264012406 RNA/DNA hybrid binding site [nucleotide binding]; other site 572264012407 active site 572264012408 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 572264012409 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 572264012410 putative dimer interface [polypeptide binding]; other site 572264012411 putative anticodon binding site; other site 572264012412 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 572264012413 homodimer interface [polypeptide binding]; other site 572264012414 motif 1; other site 572264012415 motif 2; other site 572264012416 active site 572264012417 motif 3; other site 572264012418 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 572264012419 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 572264012420 putative tRNA-binding site [nucleotide binding]; other site 572264012421 B3/4 domain; Region: B3_4; pfam03483 572264012422 tRNA synthetase B5 domain; Region: B5; smart00874 572264012423 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 572264012424 dimer interface [polypeptide binding]; other site 572264012425 motif 1; other site 572264012426 motif 3; other site 572264012427 motif 2; other site 572264012428 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 572264012429 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 572264012430 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 572264012431 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 572264012432 dimer interface [polypeptide binding]; other site 572264012433 motif 1; other site 572264012434 active site 572264012435 motif 2; other site 572264012436 motif 3; other site 572264012437 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 572264012438 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 572264012439 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 572264012440 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 572264012441 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572264012442 Zn2+ binding site [ion binding]; other site 572264012443 Mg2+ binding site [ion binding]; other site 572264012444 CAAX protease self-immunity; Region: Abi; pfam02517 572264012445 CAAX protease self-immunity; Region: Abi; pfam02517 572264012446 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 572264012447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264012448 putative substrate translocation pore; other site 572264012449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264012450 HlyD family secretion protein; Region: HlyD_3; pfam13437 572264012451 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264012452 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264012453 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 572264012454 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 572264012455 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 572264012456 oligomer interface [polypeptide binding]; other site 572264012457 active site 572264012458 metal binding site [ion binding]; metal-binding site 572264012459 dUTPase; Region: dUTPase_2; pfam08761 572264012460 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 572264012461 active site 572264012462 homodimer interface [polypeptide binding]; other site 572264012463 metal binding site [ion binding]; metal-binding site 572264012464 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 572264012465 23S rRNA binding site [nucleotide binding]; other site 572264012466 L21 binding site [polypeptide binding]; other site 572264012467 L13 binding site [polypeptide binding]; other site 572264012468 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 572264012469 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 572264012470 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 572264012471 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 572264012472 Ribosomal protein L20 leader 572264012473 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 572264012474 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 572264012475 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 572264012476 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 572264012477 active site 572264012478 dimer interface [polypeptide binding]; other site 572264012479 motif 1; other site 572264012480 motif 2; other site 572264012481 motif 3; other site 572264012482 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 572264012483 anticodon binding site; other site 572264012484 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 572264012485 primosomal protein DnaI; Reviewed; Region: PRK08939 572264012486 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 572264012487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264012488 Walker A motif; other site 572264012489 ATP binding site [chemical binding]; other site 572264012490 Walker B motif; other site 572264012491 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 572264012492 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 572264012493 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 572264012494 ATP cone domain; Region: ATP-cone; pfam03477 572264012495 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 572264012496 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 572264012497 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 572264012498 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 572264012499 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 572264012500 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 572264012501 CoA-binding site [chemical binding]; other site 572264012502 ATP-binding [chemical binding]; other site 572264012503 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 572264012504 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 572264012505 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 572264012506 DNA binding site [nucleotide binding] 572264012507 catalytic residue [active] 572264012508 H2TH interface [polypeptide binding]; other site 572264012509 putative catalytic residues [active] 572264012510 turnover-facilitating residue; other site 572264012511 intercalation triad [nucleotide binding]; other site 572264012512 8OG recognition residue [nucleotide binding]; other site 572264012513 putative reading head residues; other site 572264012514 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 572264012515 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 572264012516 DNA polymerase I; Provisional; Region: PRK05755 572264012517 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 572264012518 active site 572264012519 metal binding site 1 [ion binding]; metal-binding site 572264012520 putative 5' ssDNA interaction site; other site 572264012521 metal binding site 3; metal-binding site 572264012522 metal binding site 2 [ion binding]; metal-binding site 572264012523 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 572264012524 putative DNA binding site [nucleotide binding]; other site 572264012525 putative metal binding site [ion binding]; other site 572264012526 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 572264012527 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 572264012528 active site 572264012529 DNA binding site [nucleotide binding] 572264012530 catalytic site [active] 572264012531 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264012532 dimerization interface [polypeptide binding]; other site 572264012533 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 572264012534 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572264012535 putative active site [active] 572264012536 heme pocket [chemical binding]; other site 572264012537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264012538 dimer interface [polypeptide binding]; other site 572264012539 phosphorylation site [posttranslational modification] 572264012540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264012541 ATP binding site [chemical binding]; other site 572264012542 Mg2+ binding site [ion binding]; other site 572264012543 G-X-G motif; other site 572264012544 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264012545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264012546 active site 572264012547 phosphorylation site [posttranslational modification] 572264012548 intermolecular recognition site; other site 572264012549 dimerization interface [polypeptide binding]; other site 572264012550 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264012551 DNA binding site [nucleotide binding] 572264012552 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 572264012553 active site 2 [active] 572264012554 active site 1 [active] 572264012555 malate dehydrogenase; Reviewed; Region: PRK06223 572264012556 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 572264012557 NAD(P) binding site [chemical binding]; other site 572264012558 dimer interface [polypeptide binding]; other site 572264012559 tetramer (dimer of dimers) interface [polypeptide binding]; other site 572264012560 substrate binding site [chemical binding]; other site 572264012561 isocitrate dehydrogenase; Reviewed; Region: PRK07006 572264012562 isocitrate dehydrogenase; Validated; Region: PRK07362 572264012563 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 572264012564 dimer interface [polypeptide binding]; other site 572264012565 Citrate synthase; Region: Citrate_synt; pfam00285 572264012566 active site 572264012567 citrylCoA binding site [chemical binding]; other site 572264012568 oxalacetate/citrate binding site [chemical binding]; other site 572264012569 coenzyme A binding site [chemical binding]; other site 572264012570 catalytic triad [active] 572264012571 Protein of unknown function (DUF441); Region: DUF441; pfam04284 572264012572 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 572264012573 Domain of unknown function DUF20; Region: UPF0118; pfam01594 572264012574 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 572264012575 pyruvate kinase; Provisional; Region: PRK06354 572264012576 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 572264012577 domain interfaces; other site 572264012578 active site 572264012579 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 572264012580 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 572264012581 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 572264012582 active site 572264012583 ADP/pyrophosphate binding site [chemical binding]; other site 572264012584 dimerization interface [polypeptide binding]; other site 572264012585 allosteric effector site; other site 572264012586 fructose-1,6-bisphosphate binding site; other site 572264012587 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 572264012588 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 572264012589 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 572264012590 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 572264012591 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 572264012592 Transcriptional regulators [Transcription]; Region: FadR; COG2186 572264012593 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572264012594 DNA-binding site [nucleotide binding]; DNA binding site 572264012595 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 572264012596 Malic enzyme, N-terminal domain; Region: malic; pfam00390 572264012597 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 572264012598 putative NAD(P) binding site [chemical binding]; other site 572264012599 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 572264012600 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 572264012601 active site 572264012602 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 572264012603 generic binding surface II; other site 572264012604 generic binding surface I; other site 572264012605 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 572264012606 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 572264012607 DHH family; Region: DHH; pfam01368 572264012608 DHHA1 domain; Region: DHHA1; pfam02272 572264012609 YtpI-like protein; Region: YtpI; pfam14007 572264012610 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 572264012611 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 572264012612 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572264012613 DNA-binding site [nucleotide binding]; DNA binding site 572264012614 DRTGG domain; Region: DRTGG; pfam07085 572264012615 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 572264012616 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 572264012617 active site 2 [active] 572264012618 active site 1 [active] 572264012619 metal-dependent hydrolase; Provisional; Region: PRK00685 572264012620 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 572264012621 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 572264012622 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 572264012623 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 572264012624 active site 572264012625 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 572264012626 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 572264012627 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 572264012628 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 572264012629 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 572264012630 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 572264012631 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264012632 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 572264012633 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572264012634 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264012635 Coenzyme A binding pocket [chemical binding]; other site 572264012636 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572264012637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264012638 non-specific DNA binding site [nucleotide binding]; other site 572264012639 salt bridge; other site 572264012640 sequence-specific DNA binding site [nucleotide binding]; other site 572264012641 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 572264012642 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 572264012643 hexamer interface [polypeptide binding]; other site 572264012644 ligand binding site [chemical binding]; other site 572264012645 putative active site [active] 572264012646 NAD(P) binding site [chemical binding]; other site 572264012647 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 572264012648 classical (c) SDRs; Region: SDR_c; cd05233 572264012649 NAD(P) binding site [chemical binding]; other site 572264012650 active site 572264012651 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 572264012652 Ligand Binding Site [chemical binding]; other site 572264012653 argininosuccinate lyase; Provisional; Region: PRK00855 572264012654 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 572264012655 active sites [active] 572264012656 tetramer interface [polypeptide binding]; other site 572264012657 argininosuccinate synthase; Provisional; Region: PRK13820 572264012658 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 572264012659 ANP binding site [chemical binding]; other site 572264012660 Substrate Binding Site II [chemical binding]; other site 572264012661 Substrate Binding Site I [chemical binding]; other site 572264012662 Uncharacterized conserved protein [Function unknown]; Region: COG1284 572264012663 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 572264012664 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 572264012665 EcsC protein family; Region: EcsC; pfam12787 572264012666 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 572264012667 nudix motif; other site 572264012668 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 572264012669 propionate/acetate kinase; Provisional; Region: PRK12379 572264012670 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 572264012671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264012672 S-adenosylmethionine binding site [chemical binding]; other site 572264012673 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 572264012674 dimer interface [polypeptide binding]; other site 572264012675 catalytic triad [active] 572264012676 peroxidatic and resolving cysteines [active] 572264012677 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 572264012678 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 572264012679 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 572264012680 ATP-NAD kinase; Region: NAD_kinase; pfam01513 572264012681 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 572264012682 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 572264012683 active site 572264012684 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572264012685 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 572264012686 dimer interface [polypeptide binding]; other site 572264012687 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 572264012688 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 572264012689 active site 572264012690 acyl-activating enzyme (AAE) consensus motif; other site 572264012691 putative CoA binding site [chemical binding]; other site 572264012692 AMP binding site [chemical binding]; other site 572264012693 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 572264012694 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 572264012695 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 572264012696 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 572264012697 Ligand Binding Site [chemical binding]; other site 572264012698 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 572264012699 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 572264012700 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572264012701 catalytic residue [active] 572264012702 septation ring formation regulator EzrA; Provisional; Region: PRK04778 572264012703 Transcriptional regulator [Transcription]; Region: LysR; COG0583 572264012704 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572264012705 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 572264012706 dimerization interface [polypeptide binding]; other site 572264012707 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 572264012708 EamA-like transporter family; Region: EamA; pfam00892 572264012709 EamA-like transporter family; Region: EamA; pfam00892 572264012710 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264012711 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264012712 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 572264012713 GAF domain; Region: GAF_2; pfam13185 572264012714 methionine gamma-lyase; Provisional; Region: PRK06767 572264012715 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 572264012716 homodimer interface [polypeptide binding]; other site 572264012717 substrate-cofactor binding pocket; other site 572264012718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264012719 catalytic residue [active] 572264012720 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 572264012721 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 572264012722 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572264012723 RNA binding surface [nucleotide binding]; other site 572264012724 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 572264012725 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 572264012726 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 572264012727 active site 572264012728 HIGH motif; other site 572264012729 dimer interface [polypeptide binding]; other site 572264012730 KMSKS motif; other site 572264012731 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572264012732 RNA binding surface [nucleotide binding]; other site 572264012733 acetyl-CoA synthetase; Provisional; Region: PRK04319 572264012734 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 572264012735 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 572264012736 active site 572264012737 acyl-activating enzyme (AAE) consensus motif; other site 572264012738 putative CoA binding site [chemical binding]; other site 572264012739 AMP binding site [chemical binding]; other site 572264012740 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 572264012741 Coenzyme A binding pocket [chemical binding]; other site 572264012742 FOG: CBS domain [General function prediction only]; Region: COG0517 572264012743 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 572264012744 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 572264012745 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 572264012746 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 572264012747 active site 572264012748 Zn binding site [ion binding]; other site 572264012749 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 572264012750 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264012751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264012752 active site 572264012753 phosphorylation site [posttranslational modification] 572264012754 intermolecular recognition site; other site 572264012755 dimerization interface [polypeptide binding]; other site 572264012756 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264012757 DNA binding site [nucleotide binding] 572264012758 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264012759 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264012760 dimerization interface [polypeptide binding]; other site 572264012761 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264012762 dimer interface [polypeptide binding]; other site 572264012763 phosphorylation site [posttranslational modification] 572264012764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264012765 ATP binding site [chemical binding]; other site 572264012766 Mg2+ binding site [ion binding]; other site 572264012767 G-X-G motif; other site 572264012768 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 572264012769 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 572264012770 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 572264012771 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 572264012772 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 572264012773 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 572264012774 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 572264012775 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 572264012776 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 572264012777 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 572264012778 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 572264012779 catabolite control protein A; Region: ccpA; TIGR01481 572264012780 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 572264012781 DNA binding site [nucleotide binding] 572264012782 domain linker motif; other site 572264012783 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 572264012784 dimerization interface [polypeptide binding]; other site 572264012785 effector binding site; other site 572264012786 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 572264012787 putative dimer interface [polypeptide binding]; other site 572264012788 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 572264012789 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 572264012790 putative dimer interface [polypeptide binding]; other site 572264012791 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 572264012792 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 572264012793 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 572264012794 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 572264012795 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 572264012796 FtsX-like permease family; Region: FtsX; pfam02687 572264012797 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572264012798 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572264012799 Walker A/P-loop; other site 572264012800 ATP binding site [chemical binding]; other site 572264012801 Q-loop/lid; other site 572264012802 ABC transporter signature motif; other site 572264012803 Walker B; other site 572264012804 D-loop; other site 572264012805 H-loop/switch region; other site 572264012806 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 572264012807 Coenzyme A binding pocket [chemical binding]; other site 572264012808 Protein of unknown function (DUF3632); Region: DUF3632; pfam12311 572264012809 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 572264012810 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 572264012811 Coenzyme A binding pocket [chemical binding]; other site 572264012812 Predicted transcriptional regulators [Transcription]; Region: COG1695 572264012813 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 572264012814 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 572264012815 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 572264012816 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 572264012817 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 572264012818 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 572264012819 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 572264012820 active site 572264012821 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 572264012822 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 572264012823 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 572264012824 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 572264012825 putative tRNA-binding site [nucleotide binding]; other site 572264012826 hypothetical protein; Provisional; Region: PRK13668 572264012827 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 572264012828 catalytic residues [active] 572264012829 NTPase; Reviewed; Region: PRK03114 572264012830 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 572264012831 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 572264012832 oligomer interface [polypeptide binding]; other site 572264012833 active site 572264012834 metal binding site [ion binding]; metal-binding site 572264012835 Predicted small secreted protein [Function unknown]; Region: COG5584 572264012836 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572264012837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264012838 S-adenosylmethionine binding site [chemical binding]; other site 572264012839 YtzH-like protein; Region: YtzH; pfam14165 572264012840 Phosphotransferase enzyme family; Region: APH; pfam01636 572264012841 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 572264012842 active site 572264012843 substrate binding site [chemical binding]; other site 572264012844 ATP binding site [chemical binding]; other site 572264012845 pullulanase, type I; Region: pulA_typeI; TIGR02104 572264012846 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 572264012847 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 572264012848 Ca binding site [ion binding]; other site 572264012849 active site 572264012850 catalytic site [active] 572264012851 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 572264012852 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 572264012853 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 572264012854 dipeptidase PepV; Reviewed; Region: PRK07318 572264012855 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 572264012856 active site 572264012857 metal binding site [ion binding]; metal-binding site 572264012858 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 572264012859 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 572264012860 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572264012861 RNA binding surface [nucleotide binding]; other site 572264012862 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 572264012863 active site 572264012864 uracil binding [chemical binding]; other site 572264012865 stage V sporulation protein B; Region: spore_V_B; TIGR02900 572264012866 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 572264012867 HI0933-like protein; Region: HI0933_like; pfam03486 572264012868 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572264012869 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 572264012870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264012871 putative substrate translocation pore; other site 572264012872 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264012873 dimerization interface [polypeptide binding]; other site 572264012874 putative DNA binding site [nucleotide binding]; other site 572264012875 putative Zn2+ binding site [ion binding]; other site 572264012876 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 572264012877 putative hydrophobic ligand binding site [chemical binding]; other site 572264012878 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 572264012879 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 572264012880 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 572264012881 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 572264012882 glucose-1-dehydrogenase; Provisional; Region: PRK08936 572264012883 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 572264012884 NAD binding site [chemical binding]; other site 572264012885 homodimer interface [polypeptide binding]; other site 572264012886 active site 572264012887 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 572264012888 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 572264012889 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 572264012890 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 572264012891 MoaE interaction surface [polypeptide binding]; other site 572264012892 MoeB interaction surface [polypeptide binding]; other site 572264012893 thiocarboxylated glycine; other site 572264012894 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 572264012895 MoaE homodimer interface [polypeptide binding]; other site 572264012896 MoaD interaction [polypeptide binding]; other site 572264012897 active site residues [active] 572264012898 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 572264012899 Walker A motif; other site 572264012900 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 572264012901 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 572264012902 dimer interface [polypeptide binding]; other site 572264012903 putative functional site; other site 572264012904 putative MPT binding site; other site 572264012905 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 572264012906 trimer interface [polypeptide binding]; other site 572264012907 dimer interface [polypeptide binding]; other site 572264012908 putative active site [active] 572264012909 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 572264012910 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 572264012911 ATP binding site [chemical binding]; other site 572264012912 substrate interface [chemical binding]; other site 572264012913 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 572264012914 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572264012915 FeS/SAM binding site; other site 572264012916 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 572264012917 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 572264012918 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 572264012919 active site residue [active] 572264012920 homoserine O-acetyltransferase; Provisional; Region: PRK06765 572264012921 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 572264012922 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 572264012923 Spore germination protein; Region: Spore_permease; pfam03845 572264012924 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 572264012925 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 572264012926 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 572264012927 putative nucleotide binding site [chemical binding]; other site 572264012928 putative metal binding site [ion binding]; other site 572264012929 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 572264012930 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 572264012931 HIGH motif; other site 572264012932 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 572264012933 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 572264012934 active site 572264012935 KMSKS motif; other site 572264012936 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 572264012937 tRNA binding surface [nucleotide binding]; other site 572264012938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264012939 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264012940 putative substrate translocation pore; other site 572264012941 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 572264012942 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 572264012943 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 572264012944 TrkA-C domain; Region: TrkA_C; pfam02080 572264012945 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 572264012946 Int/Topo IB signature motif; other site 572264012947 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 572264012948 FtsX-like permease family; Region: FtsX; pfam02687 572264012949 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572264012950 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572264012951 Walker A/P-loop; other site 572264012952 ATP binding site [chemical binding]; other site 572264012953 Q-loop/lid; other site 572264012954 ABC transporter signature motif; other site 572264012955 Walker B; other site 572264012956 D-loop; other site 572264012957 H-loop/switch region; other site 572264012958 Protein of unknown function (DUF418); Region: DUF418; cl12135 572264012959 Protein of unknown function (DUF418); Region: DUF418; pfam04235 572264012960 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 572264012961 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 572264012962 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572264012963 FeS/SAM binding site; other site 572264012964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264012965 S-adenosylmethionine binding site [chemical binding]; other site 572264012966 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 572264012967 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 572264012968 Walker A/P-loop; other site 572264012969 ATP binding site [chemical binding]; other site 572264012970 Q-loop/lid; other site 572264012971 ABC transporter signature motif; other site 572264012972 Walker B; other site 572264012973 D-loop; other site 572264012974 H-loop/switch region; other site 572264012975 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 572264012976 aspartate racemase; Region: asp_race; TIGR00035 572264012977 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 572264012978 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 572264012979 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 572264012980 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 572264012981 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 572264012982 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572264012983 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 572264012984 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 572264012985 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 572264012986 trimer interface [polypeptide binding]; other site 572264012987 putative metal binding site [ion binding]; other site 572264012988 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 572264012989 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 572264012990 active site 572264012991 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572264012992 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 572264012993 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 572264012994 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 572264012995 GTP binding site; other site 572264012996 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 572264012997 MPT binding site; other site 572264012998 trimer interface [polypeptide binding]; other site 572264012999 S-adenosylmethionine synthetase; Validated; Region: PRK05250 572264013000 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 572264013001 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 572264013002 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 572264013003 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 572264013004 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 572264013005 active site 572264013006 substrate-binding site [chemical binding]; other site 572264013007 metal-binding site [ion binding] 572264013008 ATP binding site [chemical binding]; other site 572264013009 ATP synthase I chain; Region: ATP_synt_I; pfam03899 572264013010 EamA-like transporter family; Region: EamA; pfam00892 572264013011 EamA-like transporter family; Region: EamA; pfam00892 572264013012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 572264013013 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 572264013014 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264013015 motif II; other site 572264013016 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 572264013017 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 572264013018 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 572264013019 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 572264013020 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264013021 motif II; other site 572264013022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264013023 ATP binding site [chemical binding]; other site 572264013024 Mg2+ binding site [ion binding]; other site 572264013025 G-X-G motif; other site 572264013026 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264013027 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264013028 dimer interface [polypeptide binding]; other site 572264013029 phosphorylation site [posttranslational modification] 572264013030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264013031 ATP binding site [chemical binding]; other site 572264013032 Mg2+ binding site [ion binding]; other site 572264013033 G-X-G motif; other site 572264013034 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572264013035 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 572264013036 Secretory lipase; Region: LIP; pfam03583 572264013037 Sulfatase; Region: Sulfatase; pfam00884 572264013038 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 572264013039 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 572264013040 NMT1-like family; Region: NMT1_2; pfam13379 572264013041 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 572264013042 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 572264013043 Walker A/P-loop; other site 572264013044 ATP binding site [chemical binding]; other site 572264013045 Q-loop/lid; other site 572264013046 ABC transporter signature motif; other site 572264013047 Walker B; other site 572264013048 D-loop; other site 572264013049 H-loop/switch region; other site 572264013050 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 572264013051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264013052 dimer interface [polypeptide binding]; other site 572264013053 conserved gate region; other site 572264013054 putative PBP binding loops; other site 572264013055 ABC-ATPase subunit interface; other site 572264013056 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 572264013057 active site 572264013058 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 572264013059 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264013060 motif II; other site 572264013061 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 572264013062 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 572264013063 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 572264013064 nudix motif; other site 572264013065 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 572264013066 S-ribosylhomocysteinase; Provisional; Region: PRK02260 572264013067 Haemolytic domain; Region: Haemolytic; pfam01809 572264013068 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 572264013069 active site clefts [active] 572264013070 zinc binding site [ion binding]; other site 572264013071 dimer interface [polypeptide binding]; other site 572264013072 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 572264013073 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 572264013074 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 572264013075 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 572264013076 S-layer homology domain; Region: SLH; pfam00395 572264013077 S-layer homology domain; Region: SLH; pfam00395 572264013078 S-layer homology domain; Region: SLH; pfam00395 572264013079 Excalibur calcium-binding domain; Region: Excalibur; smart00894 572264013080 Uncharacterized conserved protein [Function unknown]; Region: COG1434 572264013081 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 572264013082 putative active site [active] 572264013083 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 572264013084 Uncharacterized conserved protein [Function unknown]; Region: COG1284 572264013085 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 572264013086 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 572264013087 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 572264013088 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 572264013089 Predicted membrane protein [Function unknown]; Region: COG3766 572264013090 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 572264013091 hypothetical protein; Provisional; Region: PRK12473 572264013092 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 572264013093 DNA binding residues [nucleotide binding] 572264013094 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 572264013095 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 572264013096 active site 572264013097 catalytic residues [active] 572264013098 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 572264013099 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 572264013100 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 572264013101 G1 box; other site 572264013102 GTP/Mg2+ binding site [chemical binding]; other site 572264013103 Switch I region; other site 572264013104 G2 box; other site 572264013105 G3 box; other site 572264013106 Switch II region; other site 572264013107 G4 box; other site 572264013108 G5 box; other site 572264013109 Nucleoside recognition; Region: Gate; pfam07670 572264013110 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 572264013111 Nucleoside recognition; Region: Gate; pfam07670 572264013112 FeoA domain; Region: FeoA; pfam04023 572264013113 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 572264013114 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264013115 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264013116 dimerization interface [polypeptide binding]; other site 572264013117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264013118 dimer interface [polypeptide binding]; other site 572264013119 phosphorylation site [posttranslational modification] 572264013120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264013121 ATP binding site [chemical binding]; other site 572264013122 Mg2+ binding site [ion binding]; other site 572264013123 G-X-G motif; other site 572264013124 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264013125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264013126 active site 572264013127 phosphorylation site [posttranslational modification] 572264013128 intermolecular recognition site; other site 572264013129 dimerization interface [polypeptide binding]; other site 572264013130 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264013131 DNA binding site [nucleotide binding] 572264013132 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 572264013133 active site 572264013134 catalytic site [active] 572264013135 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 572264013136 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572264013137 active site 572264013138 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 572264013139 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 572264013140 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 572264013141 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 572264013142 Probable transposase; Region: OrfB_IS605; pfam01385 572264013143 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 572264013144 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 572264013145 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 572264013146 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 572264013147 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 572264013148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264013149 S-adenosylmethionine binding site [chemical binding]; other site 572264013150 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 572264013151 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 572264013152 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 572264013153 YolD-like protein; Region: YolD; pfam08863 572264013154 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 572264013155 FtsX-like permease family; Region: FtsX; pfam02687 572264013156 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572264013157 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572264013158 Walker A/P-loop; other site 572264013159 ATP binding site [chemical binding]; other site 572264013160 Q-loop/lid; other site 572264013161 ABC transporter signature motif; other site 572264013162 Walker B; other site 572264013163 D-loop; other site 572264013164 H-loop/switch region; other site 572264013165 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 572264013166 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 572264013167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 572264013168 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264013169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264013170 active site 572264013171 phosphorylation site [posttranslational modification] 572264013172 intermolecular recognition site; other site 572264013173 dimerization interface [polypeptide binding]; other site 572264013174 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264013175 DNA binding site [nucleotide binding] 572264013176 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264013177 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 572264013178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264013179 ATP binding site [chemical binding]; other site 572264013180 Mg2+ binding site [ion binding]; other site 572264013181 G-X-G motif; other site 572264013182 FtsX-like permease family; Region: FtsX; pfam02687 572264013183 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572264013184 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572264013185 Walker A/P-loop; other site 572264013186 ATP binding site [chemical binding]; other site 572264013187 Q-loop/lid; other site 572264013188 ABC transporter signature motif; other site 572264013189 Walker B; other site 572264013190 D-loop; other site 572264013191 H-loop/switch region; other site 572264013192 FtsX-like permease family; Region: FtsX; pfam02687 572264013193 GntP family permease; Region: GntP_permease; pfam02447 572264013194 fructuronate transporter; Provisional; Region: PRK10034; cl15264 572264013195 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 572264013196 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572264013197 DNA-binding site [nucleotide binding]; DNA binding site 572264013198 UTRA domain; Region: UTRA; pfam07702 572264013199 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 572264013200 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 572264013201 substrate binding site [chemical binding]; other site 572264013202 ATP binding site [chemical binding]; other site 572264013203 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 572264013204 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 572264013205 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572264013206 catalytic residue [active] 572264013207 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 572264013208 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 572264013209 active site 572264013210 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 572264013211 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264013212 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264013213 dimerization interface [polypeptide binding]; other site 572264013214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264013215 dimer interface [polypeptide binding]; other site 572264013216 phosphorylation site [posttranslational modification] 572264013217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264013218 ATP binding site [chemical binding]; other site 572264013219 Mg2+ binding site [ion binding]; other site 572264013220 G-X-G motif; other site 572264013221 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264013222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264013223 active site 572264013224 phosphorylation site [posttranslational modification] 572264013225 intermolecular recognition site; other site 572264013226 dimerization interface [polypeptide binding]; other site 572264013227 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264013228 DNA binding site [nucleotide binding] 572264013229 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 572264013230 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 572264013231 active site 572264013232 octamer interface [polypeptide binding]; other site 572264013233 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 572264013234 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 572264013235 acyl-activating enzyme (AAE) consensus motif; other site 572264013236 putative AMP binding site [chemical binding]; other site 572264013237 putative active site [active] 572264013238 putative CoA binding site [chemical binding]; other site 572264013239 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572264013240 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 572264013241 substrate binding site [chemical binding]; other site 572264013242 oxyanion hole (OAH) forming residues; other site 572264013243 trimer interface [polypeptide binding]; other site 572264013244 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 572264013245 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 572264013246 nucleophilic elbow; other site 572264013247 catalytic triad; other site 572264013248 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 572264013249 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 572264013250 dimer interface [polypeptide binding]; other site 572264013251 tetramer interface [polypeptide binding]; other site 572264013252 PYR/PP interface [polypeptide binding]; other site 572264013253 TPP binding site [chemical binding]; other site 572264013254 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 572264013255 TPP-binding site; other site 572264013256 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 572264013257 chorismate binding enzyme; Region: Chorismate_bind; cl10555 572264013258 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 572264013259 UbiA prenyltransferase family; Region: UbiA; pfam01040 572264013260 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 572264013261 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 572264013262 DNA-binding site [nucleotide binding]; DNA binding site 572264013263 RNA-binding motif; other site 572264013264 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 572264013265 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 572264013266 active site flap/lid [active] 572264013267 nucleophilic elbow; other site 572264013268 catalytic triad [active] 572264013269 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 572264013270 homodimer interface [polypeptide binding]; other site 572264013271 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 572264013272 active site pocket [active] 572264013273 glycogen synthase; Provisional; Region: glgA; PRK00654 572264013274 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 572264013275 ADP-binding pocket [chemical binding]; other site 572264013276 homodimer interface [polypeptide binding]; other site 572264013277 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 572264013278 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 572264013279 ligand binding site; other site 572264013280 oligomer interface; other site 572264013281 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 572264013282 dimer interface [polypeptide binding]; other site 572264013283 N-terminal domain interface [polypeptide binding]; other site 572264013284 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 572264013285 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 572264013286 ligand binding site; other site 572264013287 oligomer interface; other site 572264013288 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 572264013289 dimer interface [polypeptide binding]; other site 572264013290 N-terminal domain interface [polypeptide binding]; other site 572264013291 sulfate 1 binding site; other site 572264013292 glycogen branching enzyme; Provisional; Region: PRK12313 572264013293 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 572264013294 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 572264013295 active site 572264013296 catalytic site [active] 572264013297 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 572264013298 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 572264013299 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 572264013300 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 572264013301 putative active site [active] 572264013302 catalytic triad [active] 572264013303 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 572264013304 PA/protease domain interface [polypeptide binding]; other site 572264013305 putative integrin binding motif; other site 572264013306 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 572264013307 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 572264013308 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 572264013309 dockerin binding interface; other site 572264013310 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 572264013311 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 572264013312 tetramer (dimer of dimers) interface [polypeptide binding]; other site 572264013313 NAD binding site [chemical binding]; other site 572264013314 dimer interface [polypeptide binding]; other site 572264013315 substrate binding site [chemical binding]; other site 572264013316 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 572264013317 MgtC family; Region: MgtC; pfam02308 572264013318 Ion channel; Region: Ion_trans_2; pfam07885 572264013319 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 572264013320 TrkA-N domain; Region: TrkA_N; pfam02254 572264013321 YugN-like family; Region: YugN; pfam08868 572264013322 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 572264013323 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 572264013324 active site 572264013325 dimer interface [polypeptide binding]; other site 572264013326 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 572264013327 dimer interface [polypeptide binding]; other site 572264013328 active site 572264013329 Domain of unknown function (DUF378); Region: DUF378; pfam04070 572264013330 general stress protein 13; Validated; Region: PRK08059 572264013331 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 572264013332 RNA binding site [nucleotide binding]; other site 572264013333 hypothetical protein; Validated; Region: PRK07682 572264013334 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572264013335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264013336 homodimer interface [polypeptide binding]; other site 572264013337 catalytic residue [active] 572264013338 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 572264013339 AsnC family; Region: AsnC_trans_reg; pfam01037 572264013340 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 572264013341 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 572264013342 dimerization interface [polypeptide binding]; other site 572264013343 ligand binding site [chemical binding]; other site 572264013344 NADP binding site [chemical binding]; other site 572264013345 catalytic site [active] 572264013346 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 572264013347 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 572264013348 nucleophilic elbow; other site 572264013349 catalytic triad; other site 572264013350 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 572264013351 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 572264013352 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572264013353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264013354 homodimer interface [polypeptide binding]; other site 572264013355 catalytic residue [active] 572264013356 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 572264013357 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 572264013358 E-class dimer interface [polypeptide binding]; other site 572264013359 P-class dimer interface [polypeptide binding]; other site 572264013360 active site 572264013361 Cu2+ binding site [ion binding]; other site 572264013362 Zn2+ binding site [ion binding]; other site 572264013363 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 572264013364 Kinase associated protein B; Region: KapB; pfam08810 572264013365 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 572264013366 active site 572264013367 catalytic site [active] 572264013368 substrate binding site [chemical binding]; other site 572264013369 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 572264013370 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 572264013371 transmembrane helices; other site 572264013372 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 572264013373 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 572264013374 active site 572264013375 glycyl-tRNA synthetase; Provisional; Region: PRK04173 572264013376 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 572264013377 motif 1; other site 572264013378 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 572264013379 active site 572264013380 motif 2; other site 572264013381 motif 3; other site 572264013382 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 572264013383 anticodon binding site; other site 572264013384 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 572264013385 CoenzymeA binding site [chemical binding]; other site 572264013386 subunit interaction site [polypeptide binding]; other site 572264013387 PHB binding site; other site 572264013388 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 572264013389 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 572264013390 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 572264013391 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 572264013392 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 572264013393 active site 572264013394 tetramer interface; other site 572264013395 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 572264013396 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 572264013397 active site 572264013398 substrate binding site [chemical binding]; other site 572264013399 metal binding site [ion binding]; metal-binding site 572264013400 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 572264013401 Uncharacterized conserved protein [Function unknown]; Region: COG1624 572264013402 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 572264013403 multifunctional aminopeptidase A; Provisional; Region: PRK00913 572264013404 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 572264013405 interface (dimer of trimers) [polypeptide binding]; other site 572264013406 Substrate-binding/catalytic site; other site 572264013407 Zn-binding sites [ion binding]; other site 572264013408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 572264013409 Putative membrane protein; Region: YuiB; pfam14068 572264013410 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 572264013411 nudix motif; other site 572264013412 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 572264013413 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572264013414 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 572264013415 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572264013416 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572264013417 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 572264013418 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 572264013419 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 572264013420 Domain of unknown function DUF11; Region: DUF11; pfam01345 572264013421 Domain of unknown function DUF11; Region: DUF11; pfam01345 572264013422 Domain of unknown function DUF11; Region: DUF11; pfam01345 572264013423 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 572264013424 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 572264013425 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 572264013426 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 572264013427 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 572264013428 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 572264013429 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 572264013430 conserved repeat domain; Region: B_ant_repeat; TIGR01451 572264013431 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 572264013432 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 572264013433 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 572264013434 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 572264013435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 572264013436 H+ Antiporter protein; Region: 2A0121; TIGR00900 572264013437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264013438 putative substrate translocation pore; other site 572264013439 Helix-turn-helix domain; Region: HTH_36; pfam13730 572264013440 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 572264013441 Protein of unknown function (DUF523); Region: DUF523; pfam04463 572264013442 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 572264013443 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 572264013444 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 572264013445 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 572264013446 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 572264013447 hypothetical protein; Provisional; Region: PRK13669 572264013448 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 572264013449 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572264013450 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 572264013451 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572264013452 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264013453 Walker A/P-loop; other site 572264013454 ATP binding site [chemical binding]; other site 572264013455 Q-loop/lid; other site 572264013456 ABC transporter signature motif; other site 572264013457 Walker B; other site 572264013458 D-loop; other site 572264013459 H-loop/switch region; other site 572264013460 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 572264013461 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 572264013462 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 572264013463 PhnA protein; Region: PhnA; pfam03831 572264013464 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 572264013465 CAAX protease self-immunity; Region: Abi; pfam02517 572264013466 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 572264013467 active site 572264013468 NTP binding site [chemical binding]; other site 572264013469 metal binding triad [ion binding]; metal-binding site 572264013470 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 572264013471 NifU-like domain; Region: NifU; pfam01106 572264013472 spore coat protein YutH; Region: spore_yutH; TIGR02905 572264013473 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 572264013474 tetramer interfaces [polypeptide binding]; other site 572264013475 binuclear metal-binding site [ion binding]; other site 572264013476 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 572264013477 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 572264013478 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 572264013479 FtsX-like permease family; Region: FtsX; pfam02687 572264013480 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 572264013481 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 572264013482 FtsX-like permease family; Region: FtsX; pfam02687 572264013483 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572264013484 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572264013485 Walker A/P-loop; other site 572264013486 ATP binding site [chemical binding]; other site 572264013487 Q-loop/lid; other site 572264013488 ABC transporter signature motif; other site 572264013489 Walker B; other site 572264013490 D-loop; other site 572264013491 H-loop/switch region; other site 572264013492 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 572264013493 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 572264013494 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 572264013495 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264013496 active site 572264013497 motif I; other site 572264013498 motif II; other site 572264013499 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264013500 Predicted transcriptional regulator [Transcription]; Region: COG2345 572264013501 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264013502 putative Zn2+ binding site [ion binding]; other site 572264013503 putative DNA binding site [nucleotide binding]; other site 572264013504 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 572264013505 Uncharacterized conserved protein [Function unknown]; Region: COG2445 572264013506 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 572264013507 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 572264013508 putative active site [active] 572264013509 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 572264013510 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 572264013511 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572264013512 RNA binding surface [nucleotide binding]; other site 572264013513 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 572264013514 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 572264013515 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 572264013516 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 572264013517 DNA binding residues [nucleotide binding] 572264013518 dimer interface [polypeptide binding]; other site 572264013519 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 572264013520 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 572264013521 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572264013522 catalytic core [active] 572264013523 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 572264013524 putative deacylase active site [active] 572264013525 lipoyl synthase; Provisional; Region: PRK05481 572264013526 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572264013527 FeS/SAM binding site; other site 572264013528 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 572264013529 Peptidase family M23; Region: Peptidase_M23; pfam01551 572264013530 sporulation protein YunB; Region: spo_yunB; TIGR02832 572264013531 Uncharacterized conserved protein [Function unknown]; Region: COG3377 572264013532 Predicted transcriptional regulators [Transcription]; Region: COG1695 572264013533 Transcriptional regulator PadR-like family; Region: PadR; cl17335 572264013534 VanZ like family; Region: VanZ; pfam04892 572264013535 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 572264013536 FeS assembly protein SufB; Region: sufB; TIGR01980 572264013537 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 572264013538 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 572264013539 trimerization site [polypeptide binding]; other site 572264013540 active site 572264013541 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 572264013542 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 572264013543 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572264013544 catalytic residue [active] 572264013545 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 572264013546 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 572264013547 FeS assembly protein SufD; Region: sufD; TIGR01981 572264013548 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 572264013549 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 572264013550 Walker A/P-loop; other site 572264013551 ATP binding site [chemical binding]; other site 572264013552 Q-loop/lid; other site 572264013553 ABC transporter signature motif; other site 572264013554 Walker B; other site 572264013555 D-loop; other site 572264013556 H-loop/switch region; other site 572264013557 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 572264013558 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 572264013559 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 572264013560 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 572264013561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572264013562 ABC-ATPase subunit interface; other site 572264013563 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 572264013564 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 572264013565 Walker A/P-loop; other site 572264013566 ATP binding site [chemical binding]; other site 572264013567 Q-loop/lid; other site 572264013568 ABC transporter signature motif; other site 572264013569 Walker B; other site 572264013570 D-loop; other site 572264013571 H-loop/switch region; other site 572264013572 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 572264013573 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 572264013574 catalytic residues [active] 572264013575 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 572264013576 putative active site [active] 572264013577 putative metal binding site [ion binding]; other site 572264013578 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 572264013579 lipoyl attachment site [posttranslational modification]; other site 572264013580 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 572264013581 ArsC family; Region: ArsC; pfam03960 572264013582 putative ArsC-like catalytic residues; other site 572264013583 putative TRX-like catalytic residues [active] 572264013584 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 572264013585 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 572264013586 active site 572264013587 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 572264013588 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 572264013589 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 572264013590 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 572264013591 tetramer (dimer of dimers) interface [polypeptide binding]; other site 572264013592 NAD binding site [chemical binding]; other site 572264013593 dimer interface [polypeptide binding]; other site 572264013594 substrate binding site [chemical binding]; other site 572264013595 Coat F domain; Region: Coat_F; pfam07875 572264013596 CAAX protease self-immunity; Region: Abi; cl00558 572264013597 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 572264013598 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264013599 salt bridge; other site 572264013600 non-specific DNA binding site [nucleotide binding]; other site 572264013601 sequence-specific DNA binding site [nucleotide binding]; other site 572264013602 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264013603 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264013604 WHG domain; Region: WHG; pfam13305 572264013605 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572264013606 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572264013607 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 572264013608 Walker A/P-loop; other site 572264013609 ATP binding site [chemical binding]; other site 572264013610 Q-loop/lid; other site 572264013611 ABC transporter signature motif; other site 572264013612 Walker B; other site 572264013613 D-loop; other site 572264013614 H-loop/switch region; other site 572264013615 Integral membrane protein DUF95; Region: DUF95; cl00572 572264013616 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572264013617 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572264013618 active site 572264013619 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 572264013620 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 572264013621 dimer interface [polypeptide binding]; other site 572264013622 active site 572264013623 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 572264013624 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 572264013625 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 572264013626 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 572264013627 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572264013628 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 572264013629 substrate binding site [chemical binding]; other site 572264013630 oxyanion hole (OAH) forming residues; other site 572264013631 YuzL-like protein; Region: YuzL; pfam14115 572264013632 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 572264013633 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 572264013634 Proline dehydrogenase; Region: Pro_dh; cl03282 572264013635 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 572264013636 Domain of unknown function DUF77; Region: DUF77; pfam01910 572264013637 Cache domain; Region: Cache_1; pfam02743 572264013638 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264013639 dimerization interface [polypeptide binding]; other site 572264013640 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572264013641 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572264013642 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572264013643 dimer interface [polypeptide binding]; other site 572264013644 putative CheW interface [polypeptide binding]; other site 572264013645 Predicted transcriptional regulators [Transcription]; Region: COG1378 572264013646 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 572264013647 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 572264013648 C-terminal domain interface [polypeptide binding]; other site 572264013649 sugar binding site [chemical binding]; other site 572264013650 TQXA domain; Region: TQXA_dom; TIGR03934 572264013651 Cna protein B-type domain; Region: Cna_B; pfam05738 572264013652 Cna protein B-type domain; Region: Cna_B; pfam05738 572264013653 Cna protein B-type domain; Region: Cna_B; pfam05738 572264013654 Cna protein B-type domain; Region: Cna_B; pfam05738 572264013655 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 572264013656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264013657 putative substrate translocation pore; other site 572264013658 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 572264013659 Spore germination protein; Region: Spore_permease; cl17796 572264013660 MAEBL; Provisional; Region: PTZ00121 572264013661 OxaA-like protein precursor; Validated; Region: PRK01622 572264013662 Uncharacterized conserved protein [Function unknown]; Region: COG1284 572264013663 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 572264013664 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 572264013665 hypothetical protein; Provisional; Region: PRK06758 572264013666 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 572264013667 active site 572264013668 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 572264013669 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264013670 non-specific DNA binding site [nucleotide binding]; other site 572264013671 salt bridge; other site 572264013672 sequence-specific DNA binding site [nucleotide binding]; other site 572264013673 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 572264013674 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 572264013675 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 572264013676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 572264013677 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 572264013678 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264013679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264013680 active site 572264013681 phosphorylation site [posttranslational modification] 572264013682 intermolecular recognition site; other site 572264013683 dimerization interface [polypeptide binding]; other site 572264013684 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264013685 DNA binding site [nucleotide binding] 572264013686 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572264013687 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264013688 dimer interface [polypeptide binding]; other site 572264013689 phosphorylation site [posttranslational modification] 572264013690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264013691 ATP binding site [chemical binding]; other site 572264013692 Mg2+ binding site [ion binding]; other site 572264013693 G-X-G motif; other site 572264013694 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 572264013695 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 572264013696 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 572264013697 active site 572264013698 HIGH motif; other site 572264013699 KMSKS motif; other site 572264013700 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 572264013701 tRNA binding surface [nucleotide binding]; other site 572264013702 anticodon binding site; other site 572264013703 Methyltransferase domain; Region: Methyltransf_23; pfam13489 572264013704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264013705 S-adenosylmethionine binding site [chemical binding]; other site 572264013706 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264013707 dimerization interface [polypeptide binding]; other site 572264013708 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572264013709 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572264013710 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572264013711 dimer interface [polypeptide binding]; other site 572264013712 putative CheW interface [polypeptide binding]; other site 572264013713 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264013714 dimerization interface [polypeptide binding]; other site 572264013715 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572264013716 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572264013717 dimer interface [polypeptide binding]; other site 572264013718 putative CheW interface [polypeptide binding]; other site 572264013719 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 572264013720 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 572264013721 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 572264013722 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 572264013723 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 572264013724 active site 572264013725 Zn binding site [ion binding]; other site 572264013726 Pirin-related protein [General function prediction only]; Region: COG1741 572264013727 Pirin; Region: Pirin; pfam02678 572264013728 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 572264013729 MarR family; Region: MarR_2; pfam12802 572264013730 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 572264013731 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 572264013732 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 572264013733 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 572264013734 TrkA-C domain; Region: TrkA_C; pfam02080 572264013735 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 572264013736 amino acid carrier protein; Region: agcS; TIGR00835 572264013737 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 572264013738 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 572264013739 dimerization interface [polypeptide binding]; other site 572264013740 DPS ferroxidase diiron center [ion binding]; other site 572264013741 ion pore; other site 572264013742 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 572264013743 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 572264013744 metal binding site [ion binding]; metal-binding site 572264013745 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 572264013746 Ferritin-like domain; Region: Ferritin; pfam00210 572264013747 ferroxidase diiron center [ion binding]; other site 572264013748 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 572264013749 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 572264013750 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 572264013751 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 572264013752 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 572264013753 Nucleoside recognition; Region: Gate; pfam07670 572264013754 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 572264013755 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 572264013756 amino acid carrier protein; Region: agcS; TIGR00835 572264013757 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 572264013758 amino acid carrier protein; Region: agcS; TIGR00835 572264013759 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 572264013760 NADH(P)-binding; Region: NAD_binding_10; pfam13460 572264013761 NAD binding site [chemical binding]; other site 572264013762 substrate binding site [chemical binding]; other site 572264013763 putative active site [active] 572264013764 Peptidase M60-like family; Region: M60-like; pfam13402 572264013765 TQXA domain; Region: TQXA_dom; TIGR03934 572264013766 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 572264013767 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 572264013768 active site 572264013769 catalytic tetrad [active] 572264013770 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 572264013771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264013772 putative substrate translocation pore; other site 572264013773 Predicted transcriptional regulators [Transcription]; Region: COG1733 572264013774 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264013775 dimerization interface [polypeptide binding]; other site 572264013776 putative DNA binding site [nucleotide binding]; other site 572264013777 putative Zn2+ binding site [ion binding]; other site 572264013778 Uncharacterized conserved protein [Function unknown]; Region: COG2427 572264013779 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 572264013780 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572264013781 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 572264013782 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 572264013783 active site 572264013784 HIGH motif; other site 572264013785 dimer interface [polypeptide binding]; other site 572264013786 KMSKS motif; other site 572264013787 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572264013788 RNA binding surface [nucleotide binding]; other site 572264013789 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 572264013790 FAD binding domain; Region: FAD_binding_4; pfam01565 572264013791 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 572264013792 SET domain; Region: SET; pfam00856 572264013793 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 572264013794 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572264013795 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572264013796 dimer interface [polypeptide binding]; other site 572264013797 putative CheW interface [polypeptide binding]; other site 572264013798 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 572264013799 putative catalytic site [active] 572264013800 putative metal binding site [ion binding]; other site 572264013801 putative phosphate binding site [ion binding]; other site 572264013802 camphor resistance protein CrcB; Provisional; Region: PRK14219 572264013803 camphor resistance protein CrcB; Provisional; Region: PRK14205 572264013804 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 572264013805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264013806 H+ Antiporter protein; Region: 2A0121; TIGR00900 572264013807 putative substrate translocation pore; other site 572264013808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264013809 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 572264013810 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264013811 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264013812 ABC transporter; Region: ABC_tran_2; pfam12848 572264013813 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264013814 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 572264013815 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572264013816 Coenzyme A binding pocket [chemical binding]; other site 572264013817 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 572264013818 Nuclease-related domain; Region: NERD; pfam08378 572264013819 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 572264013820 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 572264013821 Walker A/P-loop; other site 572264013822 ATP binding site [chemical binding]; other site 572264013823 Q-loop/lid; other site 572264013824 ABC transporter signature motif; other site 572264013825 Walker B; other site 572264013826 D-loop; other site 572264013827 H-loop/switch region; other site 572264013828 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572264013829 ABC-ATPase subunit interface; other site 572264013830 dimer interface [polypeptide binding]; other site 572264013831 putative PBP binding regions; other site 572264013832 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 572264013833 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572264013834 ABC-ATPase subunit interface; other site 572264013835 dimer interface [polypeptide binding]; other site 572264013836 putative PBP binding regions; other site 572264013837 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 572264013838 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 572264013839 intersubunit interface [polypeptide binding]; other site 572264013840 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264013841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264013842 active site 572264013843 phosphorylation site [posttranslational modification] 572264013844 intermolecular recognition site; other site 572264013845 dimerization interface [polypeptide binding]; other site 572264013846 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264013847 DNA binding site [nucleotide binding] 572264013848 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 572264013849 SmpB-tmRNA interface; other site 572264013850 ribonuclease R; Region: RNase_R; TIGR02063 572264013851 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 572264013852 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 572264013853 RNB domain; Region: RNB; pfam00773 572264013854 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 572264013855 RNA binding site [nucleotide binding]; other site 572264013856 Esterase/lipase [General function prediction only]; Region: COG1647 572264013857 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 572264013858 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 572264013859 holin-like protein; Validated; Region: PRK01658 572264013860 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 572264013861 active site 572264013862 enolase; Provisional; Region: eno; PRK00077 572264013863 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 572264013864 dimer interface [polypeptide binding]; other site 572264013865 metal binding site [ion binding]; metal-binding site 572264013866 substrate binding pocket [chemical binding]; other site 572264013867 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 572264013868 phosphoglyceromutase; Provisional; Region: PRK05434 572264013869 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 572264013870 triosephosphate isomerase; Provisional; Region: PRK14565 572264013871 substrate binding site [chemical binding]; other site 572264013872 dimer interface [polypeptide binding]; other site 572264013873 catalytic triad [active] 572264013874 Phosphoglycerate kinase; Region: PGK; pfam00162 572264013875 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 572264013876 substrate binding site [chemical binding]; other site 572264013877 hinge regions; other site 572264013878 ADP binding site [chemical binding]; other site 572264013879 catalytic site [active] 572264013880 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 572264013881 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 572264013882 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 572264013883 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 572264013884 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 572264013885 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 572264013886 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 572264013887 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 572264013888 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 572264013889 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 572264013890 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 572264013891 Helix-turn-helix domain; Region: HTH_36; pfam13730 572264013892 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 572264013893 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 572264013894 catalytic residues [active] 572264013895 catalytic nucleophile [active] 572264013896 Presynaptic Site I dimer interface [polypeptide binding]; other site 572264013897 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 572264013898 Synaptic Flat tetramer interface [polypeptide binding]; other site 572264013899 Synaptic Site I dimer interface [polypeptide binding]; other site 572264013900 DNA binding site [nucleotide binding] 572264013901 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 572264013902 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 572264013903 active site 572264013904 DNA binding site [nucleotide binding] 572264013905 Int/Topo IB signature motif; other site 572264013906 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 572264013907 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 572264013908 stage V sporulation protein AD; Provisional; Region: PRK12404 572264013909 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 572264013910 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 572264013911 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 572264013912 Predicted membrane protein [Function unknown]; Region: COG2323 572264013913 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 572264013914 Clp protease; Region: CLP_protease; pfam00574 572264013915 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 572264013916 oligomer interface [polypeptide binding]; other site 572264013917 active site residues [active] 572264013918 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 572264013919 dimerization domain swap beta strand [polypeptide binding]; other site 572264013920 regulatory protein interface [polypeptide binding]; other site 572264013921 active site 572264013922 regulatory phosphorylation site [posttranslational modification]; other site 572264013923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 572264013924 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 572264013925 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 572264013926 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 572264013927 phosphate binding site [ion binding]; other site 572264013928 putative substrate binding pocket [chemical binding]; other site 572264013929 dimer interface [polypeptide binding]; other site 572264013930 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 572264013931 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 572264013932 putative active site [active] 572264013933 nucleotide binding site [chemical binding]; other site 572264013934 nudix motif; other site 572264013935 putative metal binding site [ion binding]; other site 572264013936 Domain of unknown function (DUF368); Region: DUF368; pfam04018 572264013937 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 572264013938 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572264013939 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572264013940 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264013941 binding surface 572264013942 TPR motif; other site 572264013943 Tetratricopeptide repeat; Region: TPR_12; pfam13424 572264013944 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 572264013945 binding surface 572264013946 Tetratricopeptide repeat; Region: TPR_16; pfam13432 572264013947 TPR motif; other site 572264013948 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 572264013949 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 572264013950 trimer interface [polypeptide binding]; other site 572264013951 active site 572264013952 substrate binding site [chemical binding]; other site 572264013953 CoA binding site [chemical binding]; other site 572264013954 pyrophosphatase PpaX; Provisional; Region: PRK13288 572264013955 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264013956 active site 572264013957 motif I; other site 572264013958 motif II; other site 572264013959 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 572264013960 HPr kinase/phosphorylase; Provisional; Region: PRK05428 572264013961 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 572264013962 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 572264013963 Hpr binding site; other site 572264013964 active site 572264013965 homohexamer subunit interaction site [polypeptide binding]; other site 572264013966 Predicted membrane protein [Function unknown]; Region: COG1950 572264013967 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 572264013968 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 572264013969 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 572264013970 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 572264013971 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 572264013972 excinuclease ABC subunit B; Provisional; Region: PRK05298 572264013973 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572264013974 ATP binding site [chemical binding]; other site 572264013975 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572264013976 nucleotide binding region [chemical binding]; other site 572264013977 ATP-binding site [chemical binding]; other site 572264013978 Ultra-violet resistance protein B; Region: UvrB; pfam12344 572264013979 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 572264013980 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 572264013981 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 572264013982 DNA binding residues [nucleotide binding] 572264013983 dimer interface [polypeptide binding]; other site 572264013984 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 572264013985 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572264013986 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264013987 non-specific DNA binding site [nucleotide binding]; other site 572264013988 salt bridge; other site 572264013989 sequence-specific DNA binding site [nucleotide binding]; other site 572264013990 Predicted membrane protein [Function unknown]; Region: COG2855 572264013991 Transcriptional regulator [Transcription]; Region: LysR; COG0583 572264013992 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572264013993 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 572264013994 putative dimerization interface [polypeptide binding]; other site 572264013995 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 572264013996 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 572264013997 DNA binding residues [nucleotide binding] 572264013998 putative dimer interface [polypeptide binding]; other site 572264013999 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 572264014000 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 572264014001 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264014002 hypothetical protein; Provisional; Region: PRK12855 572264014003 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 572264014004 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 572264014005 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 572264014006 Walker A/P-loop; other site 572264014007 ATP binding site [chemical binding]; other site 572264014008 Q-loop/lid; other site 572264014009 ABC transporter signature motif; other site 572264014010 Walker B; other site 572264014011 D-loop; other site 572264014012 H-loop/switch region; other site 572264014013 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 572264014014 protein binding site [polypeptide binding]; other site 572264014015 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 572264014016 C-terminal peptidase (prc); Region: prc; TIGR00225 572264014017 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 572264014018 protein binding site [polypeptide binding]; other site 572264014019 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 572264014020 Catalytic dyad [active] 572264014021 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 572264014022 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 572264014023 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 572264014024 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 572264014025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264014026 Walker A/P-loop; other site 572264014027 ATP binding site [chemical binding]; other site 572264014028 Q-loop/lid; other site 572264014029 ABC transporter signature motif; other site 572264014030 Walker B; other site 572264014031 D-loop; other site 572264014032 H-loop/switch region; other site 572264014033 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 572264014034 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 572264014035 peptide chain release factor 2; Provisional; Region: PRK06746 572264014036 This domain is found in peptide chain release factors; Region: PCRF; smart00937 572264014037 RF-1 domain; Region: RF-1; pfam00472 572264014038 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 572264014039 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 572264014040 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 572264014041 nucleotide binding region [chemical binding]; other site 572264014042 ATP-binding site [chemical binding]; other site 572264014043 SEC-C motif; Region: SEC-C; pfam02810 572264014044 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 572264014045 30S subunit binding site; other site 572264014046 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 572264014047 DNA-binding site [nucleotide binding]; DNA binding site 572264014048 RNA-binding motif; other site 572264014049 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 572264014050 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572264014051 active site 572264014052 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 572264014053 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572264014054 ATP binding site [chemical binding]; other site 572264014055 putative Mg++ binding site [ion binding]; other site 572264014056 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572264014057 nucleotide binding region [chemical binding]; other site 572264014058 ATP-binding site [chemical binding]; other site 572264014059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 572264014060 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 572264014061 NlpC/P60 family; Region: NLPC_P60; pfam00877 572264014062 Predicted transcriptional regulators [Transcription]; Region: COG1733 572264014063 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264014064 dimerization interface [polypeptide binding]; other site 572264014065 putative DNA binding site [nucleotide binding]; other site 572264014066 putative Zn2+ binding site [ion binding]; other site 572264014067 EDD domain protein, DegV family; Region: DegV; TIGR00762 572264014068 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 572264014069 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 572264014070 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 572264014071 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 572264014072 Transcriptional regulator [Transcription]; Region: LytR; COG1316 572264014073 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 572264014074 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 572264014075 active site 572264014076 homodimer interface [polypeptide binding]; other site 572264014077 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 572264014078 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 572264014079 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 572264014080 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 572264014081 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 572264014082 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 572264014083 Mg++ binding site [ion binding]; other site 572264014084 putative catalytic motif [active] 572264014085 substrate binding site [chemical binding]; other site 572264014086 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 572264014087 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 572264014088 NodB motif; other site 572264014089 active site 572264014090 catalytic site [active] 572264014091 Zn binding site [ion binding]; other site 572264014092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572264014093 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 572264014094 Walker A motif; other site 572264014095 ATP binding site [chemical binding]; other site 572264014096 Walker B motif; other site 572264014097 arginine finger; other site 572264014098 Transcriptional antiterminator [Transcription]; Region: COG3933 572264014099 PRD domain; Region: PRD; pfam00874 572264014100 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 572264014101 active pocket/dimerization site; other site 572264014102 active site 572264014103 phosphorylation site [posttranslational modification] 572264014104 PRD domain; Region: PRD; pfam00874 572264014105 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 572264014106 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 572264014107 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 572264014108 Chromate transporter; Region: Chromate_transp; pfam02417 572264014109 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 572264014110 putative active site [active] 572264014111 YdjC motif; other site 572264014112 Mg binding site [ion binding]; other site 572264014113 putative homodimer interface [polypeptide binding]; other site 572264014114 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 572264014115 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 572264014116 NAD binding site [chemical binding]; other site 572264014117 sugar binding site [chemical binding]; other site 572264014118 divalent metal binding site [ion binding]; other site 572264014119 tetramer (dimer of dimers) interface [polypeptide binding]; other site 572264014120 dimer interface [polypeptide binding]; other site 572264014121 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 572264014122 active site 572264014123 methionine cluster; other site 572264014124 phosphorylation site [posttranslational modification] 572264014125 metal binding site [ion binding]; metal-binding site 572264014126 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 572264014127 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 572264014128 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 572264014129 active site 572264014130 P-loop; other site 572264014131 phosphorylation site [posttranslational modification] 572264014132 spermidine synthase; Provisional; Region: PRK03612 572264014133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264014134 S-adenosylmethionine binding site [chemical binding]; other site 572264014135 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 572264014136 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 572264014137 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 572264014138 LytTr DNA-binding domain; Region: LytTR; smart00850 572264014139 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 572264014140 methionine cluster; other site 572264014141 active site 572264014142 phosphorylation site [posttranslational modification] 572264014143 metal binding site [ion binding]; metal-binding site 572264014144 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 572264014145 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 572264014146 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 572264014147 active site 572264014148 P-loop; other site 572264014149 phosphorylation site [posttranslational modification] 572264014150 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 572264014151 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 572264014152 Acyltransferase family; Region: Acyl_transf_3; pfam01757 572264014153 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 572264014154 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572264014155 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 572264014156 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 572264014157 active site 572264014158 catalytic site [active] 572264014159 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014160 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 572264014161 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 572264014162 Domain of unknown function DUF11; Region: DUF11; pfam01345 572264014163 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 572264014164 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 572264014165 Domain of unknown function DUF11; Region: DUF11; cl17728 572264014166 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014167 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 572264014168 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 572264014169 Predicted membrane protein [Function unknown]; Region: COG1511 572264014170 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 572264014171 Transcriptional regulator [Transcription]; Region: LysR; COG0583 572264014172 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572264014173 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 572264014174 putative dimerization interface [polypeptide binding]; other site 572264014175 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 572264014176 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 572264014177 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 572264014178 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 572264014179 transmembrane helices; other site 572264014180 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 572264014181 ThiC-associated domain; Region: ThiC-associated; pfam13667 572264014182 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 572264014183 L-lactate permease; Region: Lactate_perm; cl00701 572264014184 glycolate transporter; Provisional; Region: PRK09695 572264014185 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 572264014186 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 572264014187 Probable transposase; Region: OrfB_IS605; pfam01385 572264014188 Tic20-like protein; Region: Tic20; pfam09685 572264014189 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 572264014190 Uncharacterized conserved protein [Function unknown]; Region: COG3339 572264014191 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 572264014192 Sulfatase; Region: Sulfatase; pfam00884 572264014193 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 572264014194 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 572264014195 homodimer interface [polypeptide binding]; other site 572264014196 substrate-cofactor binding pocket; other site 572264014197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264014198 catalytic residue [active] 572264014199 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 572264014200 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 572264014201 Nucleoside recognition; Region: Gate; pfam07670 572264014202 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 572264014203 Uncharacterized conserved protein (DUF2215); Region: DUF2215; pfam10225 572264014204 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 572264014205 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 572264014206 DXD motif; other site 572264014207 BCCT family transporter; Region: BCCT; pfam02028 572264014208 Bacterial SH3 domain; Region: SH3_3; pfam08239 572264014209 Bacterial SH3 domain; Region: SH3_3; pfam08239 572264014210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 572264014211 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 572264014212 Predicted membrane protein [Function unknown]; Region: COG4640 572264014213 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 572264014214 Double zinc ribbon; Region: DZR; pfam12773 572264014215 Double zinc ribbon; Region: DZR; pfam12773 572264014216 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 572264014217 SNF2 Helicase protein; Region: DUF3670; pfam12419 572264014218 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 572264014219 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572264014220 ATP binding site [chemical binding]; other site 572264014221 putative Mg++ binding site [ion binding]; other site 572264014222 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 572264014223 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572264014224 nucleotide binding region [chemical binding]; other site 572264014225 ATP-binding site [chemical binding]; other site 572264014226 Predicted integral membrane protein [Function unknown]; Region: COG5652 572264014227 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 572264014228 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 572264014229 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 572264014230 ComK protein; Region: ComK; pfam06338 572264014231 RNA polymerase factor sigma-70; Validated; Region: PRK06759 572264014232 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264014233 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572264014234 DNA binding residues [nucleotide binding] 572264014235 Yip1 domain; Region: Yip1; cl17815 572264014236 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 572264014237 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 572264014238 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 572264014239 FtsX-like permease family; Region: FtsX; pfam02687 572264014240 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572264014241 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572264014242 Walker A/P-loop; other site 572264014243 ATP binding site [chemical binding]; other site 572264014244 Q-loop/lid; other site 572264014245 ABC transporter signature motif; other site 572264014246 Walker B; other site 572264014247 D-loop; other site 572264014248 H-loop/switch region; other site 572264014249 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 572264014250 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 572264014251 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572264014252 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264014253 non-specific DNA binding site [nucleotide binding]; other site 572264014254 salt bridge; other site 572264014255 sequence-specific DNA binding site [nucleotide binding]; other site 572264014256 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 572264014257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264014258 putative substrate translocation pore; other site 572264014259 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 572264014260 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 572264014261 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 572264014262 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 572264014263 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264014264 dimerization interface [polypeptide binding]; other site 572264014265 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264014266 dimer interface [polypeptide binding]; other site 572264014267 phosphorylation site [posttranslational modification] 572264014268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264014269 ATP binding site [chemical binding]; other site 572264014270 Mg2+ binding site [ion binding]; other site 572264014271 G-X-G motif; other site 572264014272 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264014273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264014274 active site 572264014275 phosphorylation site [posttranslational modification] 572264014276 intermolecular recognition site; other site 572264014277 dimerization interface [polypeptide binding]; other site 572264014278 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264014279 DNA binding site [nucleotide binding] 572264014280 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 572264014281 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 572264014282 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 572264014283 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 572264014284 active site 572264014285 P-loop; other site 572264014286 phosphorylation site [posttranslational modification] 572264014287 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 572264014288 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 572264014289 active site 572264014290 phosphorylation site [posttranslational modification] 572264014291 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 572264014292 HTH domain; Region: HTH_11; pfam08279 572264014293 HTH domain; Region: HTH_11; pfam08279 572264014294 PRD domain; Region: PRD; pfam00874 572264014295 PRD domain; Region: PRD; pfam00874 572264014296 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 572264014297 active site 572264014298 P-loop; other site 572264014299 phosphorylation site [posttranslational modification] 572264014300 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 572264014301 active site 572264014302 phosphorylation site [posttranslational modification] 572264014303 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 572264014304 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 572264014305 NAD binding site [chemical binding]; other site 572264014306 homodimer interface [polypeptide binding]; other site 572264014307 active site 572264014308 substrate binding site [chemical binding]; other site 572264014309 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 572264014310 active site 572264014311 catalytic triad [active] 572264014312 oxyanion hole [active] 572264014313 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 572264014314 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 572264014315 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 572264014316 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 572264014317 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 572264014318 active site 572264014319 Cupin domain; Region: Cupin_2; cl17218 572264014320 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572264014321 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 572264014322 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 572264014323 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572264014324 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 572264014325 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 572264014326 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 572264014327 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 572264014328 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 572264014329 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572264014330 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 572264014331 colanic acid exporter; Provisional; Region: PRK10459 572264014332 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 572264014333 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 572264014334 Bacterial sugar transferase; Region: Bac_transf; pfam02397 572264014335 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 572264014336 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 572264014337 active site 572264014338 tetramer interface; other site 572264014339 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 572264014340 DNA photolyase; Region: DNA_photolyase; pfam00875 572264014341 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 572264014342 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 572264014343 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 572264014344 Chain length determinant protein; Region: Wzz; cl15801 572264014345 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 572264014346 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 572264014347 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 572264014348 rod shape-determining protein Mbl; Provisional; Region: PRK13928 572264014349 MreB and similar proteins; Region: MreB_like; cd10225 572264014350 nucleotide binding site [chemical binding]; other site 572264014351 Mg binding site [ion binding]; other site 572264014352 putative protofilament interaction site [polypeptide binding]; other site 572264014353 RodZ interaction site [polypeptide binding]; other site 572264014354 Stage III sporulation protein D; Region: SpoIIID; pfam12116 572264014355 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 572264014356 Peptidase family M23; Region: Peptidase_M23; pfam01551 572264014357 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 572264014358 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 572264014359 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 572264014360 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 572264014361 Walker A/P-loop; other site 572264014362 ATP binding site [chemical binding]; other site 572264014363 Q-loop/lid; other site 572264014364 ABC transporter signature motif; other site 572264014365 Walker B; other site 572264014366 D-loop; other site 572264014367 H-loop/switch region; other site 572264014368 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 572264014369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264014370 Walker A/P-loop; other site 572264014371 ATP binding site [chemical binding]; other site 572264014372 Q-loop/lid; other site 572264014373 ABC transporter signature motif; other site 572264014374 Walker B; other site 572264014375 D-loop; other site 572264014376 H-loop/switch region; other site 572264014377 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 572264014378 LytTr DNA-binding domain; Region: LytTR; pfam04397 572264014379 Stage II sporulation protein; Region: SpoIID; pfam08486 572264014380 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 572264014381 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 572264014382 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 572264014383 hinge; other site 572264014384 active site 572264014385 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 572264014386 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 572264014387 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 572264014388 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 572264014389 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 572264014390 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 572264014391 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 572264014392 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 572264014393 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 572264014394 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 572264014395 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 572264014396 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 572264014397 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 572264014398 4Fe-4S binding domain; Region: Fer4; cl02805 572264014399 4Fe-4S binding domain; Region: Fer4; pfam00037 572264014400 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 572264014401 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 572264014402 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 572264014403 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 572264014404 NADH dehydrogenase subunit C; Validated; Region: PRK07735 572264014405 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 572264014406 NADH dehydrogenase subunit B; Validated; Region: PRK06411 572264014407 NADH dehydrogenase subunit A; Validated; Region: PRK07756 572264014408 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572264014409 PAS domain; Region: PAS_9; pfam13426 572264014410 putative active site [active] 572264014411 heme pocket [chemical binding]; other site 572264014412 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572264014413 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572264014414 metal binding site [ion binding]; metal-binding site 572264014415 active site 572264014416 I-site; other site 572264014417 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572264014418 Protein of unknown function (DUF975); Region: DUF975; cl10504 572264014419 Protein of unknown function (DUF975); Region: DUF975; cl10504 572264014420 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 572264014421 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 572264014422 gamma subunit interface [polypeptide binding]; other site 572264014423 epsilon subunit interface [polypeptide binding]; other site 572264014424 LBP interface [polypeptide binding]; other site 572264014425 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 572264014426 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 572264014427 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 572264014428 alpha subunit interaction interface [polypeptide binding]; other site 572264014429 Walker A motif; other site 572264014430 ATP binding site [chemical binding]; other site 572264014431 Walker B motif; other site 572264014432 inhibitor binding site; inhibition site 572264014433 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 572264014434 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 572264014435 core domain interface [polypeptide binding]; other site 572264014436 delta subunit interface [polypeptide binding]; other site 572264014437 epsilon subunit interface [polypeptide binding]; other site 572264014438 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 572264014439 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 572264014440 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 572264014441 beta subunit interaction interface [polypeptide binding]; other site 572264014442 Walker A motif; other site 572264014443 ATP binding site [chemical binding]; other site 572264014444 Walker B motif; other site 572264014445 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 572264014446 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 572264014447 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 572264014448 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 572264014449 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 572264014450 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 572264014451 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 572264014452 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 572264014453 ATP synthase I chain; Region: ATP_synt_I; pfam03899 572264014454 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 572264014455 Protein of unknown function (DUF4024); Region: DUF4024; pfam13216 572264014456 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572264014457 active site 572264014458 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 572264014459 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 572264014460 dimer interface [polypeptide binding]; other site 572264014461 active site 572264014462 glycine-pyridoxal phosphate binding site [chemical binding]; other site 572264014463 folate binding site [chemical binding]; other site 572264014464 HTH-like domain; Region: HTH_21; pfam13276 572264014465 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 572264014466 Integrase core domain; Region: rve; pfam00665 572264014467 Integrase core domain; Region: rve_2; pfam13333 572264014468 Transposase; Region: HTH_Tnp_1; cl17663 572264014469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 572264014470 hypothetical protein; Provisional; Region: PRK13690 572264014471 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 572264014472 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 572264014473 Low molecular weight phosphatase family; Region: LMWPc; cd00115 572264014474 active site 572264014475 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 572264014476 HPr interaction site; other site 572264014477 glycerol kinase (GK) interaction site [polypeptide binding]; other site 572264014478 active site 572264014479 phosphorylation site [posttranslational modification] 572264014480 Predicted membrane protein [Function unknown]; Region: COG2259 572264014481 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 572264014482 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 572264014483 oligomer interface [polypeptide binding]; other site 572264014484 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 572264014485 Predicted membrane protein [Function unknown]; Region: COG1971 572264014486 Domain of unknown function DUF; Region: DUF204; pfam02659 572264014487 Domain of unknown function DUF; Region: DUF204; pfam02659 572264014488 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 572264014489 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 572264014490 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 572264014491 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 572264014492 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 572264014493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264014494 S-adenosylmethionine binding site [chemical binding]; other site 572264014495 peptide chain release factor 1; Validated; Region: prfA; PRK00591 572264014496 This domain is found in peptide chain release factors; Region: PCRF; smart00937 572264014497 RF-1 domain; Region: RF-1; pfam00472 572264014498 thymidine kinase; Provisional; Region: PRK04296 572264014499 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 572264014500 transcription termination factor Rho; Provisional; Region: rho; PRK09376 572264014501 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 572264014502 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 572264014503 RNA binding site [nucleotide binding]; other site 572264014504 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 572264014505 multimer interface [polypeptide binding]; other site 572264014506 Walker A motif; other site 572264014507 ATP binding site [chemical binding]; other site 572264014508 Walker B motif; other site 572264014509 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 572264014510 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 572264014511 putative active site [active] 572264014512 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 572264014513 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 572264014514 hinge; other site 572264014515 active site 572264014516 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 572264014517 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 572264014518 intersubunit interface [polypeptide binding]; other site 572264014519 active site 572264014520 zinc binding site [ion binding]; other site 572264014521 Na+ binding site [ion binding]; other site 572264014522 Response regulator receiver domain; Region: Response_reg; pfam00072 572264014523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264014524 active site 572264014525 phosphorylation site [posttranslational modification] 572264014526 intermolecular recognition site; other site 572264014527 dimerization interface [polypeptide binding]; other site 572264014528 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 572264014529 CTP synthetase; Validated; Region: pyrG; PRK05380 572264014530 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 572264014531 Catalytic site [active] 572264014532 active site 572264014533 UTP binding site [chemical binding]; other site 572264014534 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 572264014535 active site 572264014536 putative oxyanion hole; other site 572264014537 catalytic triad [active] 572264014538 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 572264014539 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264014540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264014541 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572264014542 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 572264014543 FAD binding site [chemical binding]; other site 572264014544 homotetramer interface [polypeptide binding]; other site 572264014545 substrate binding pocket [chemical binding]; other site 572264014546 catalytic base [active] 572264014547 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572264014548 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 572264014549 FAD binding site [chemical binding]; other site 572264014550 homotetramer interface [polypeptide binding]; other site 572264014551 substrate binding pocket [chemical binding]; other site 572264014552 catalytic base [active] 572264014553 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 572264014554 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 572264014555 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 572264014556 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 572264014557 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 572264014558 dimer interface [polypeptide binding]; other site 572264014559 active site 572264014560 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 572264014561 4Fe-4S binding domain; Region: Fer4; cl02805 572264014562 Cysteine-rich domain; Region: CCG; pfam02754 572264014563 Cysteine-rich domain; Region: CCG; pfam02754 572264014564 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 572264014565 PLD-like domain; Region: PLDc_2; pfam13091 572264014566 putative active site [active] 572264014567 catalytic site [active] 572264014568 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 572264014569 PLD-like domain; Region: PLDc_2; pfam13091 572264014570 putative active site [active] 572264014571 catalytic site [active] 572264014572 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 572264014573 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 572264014574 PAS domain S-box; Region: sensory_box; TIGR00229 572264014575 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572264014576 putative active site [active] 572264014577 heme pocket [chemical binding]; other site 572264014578 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572264014579 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572264014580 metal binding site [ion binding]; metal-binding site 572264014581 active site 572264014582 I-site; other site 572264014583 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572264014584 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 572264014585 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264014586 non-specific DNA binding site [nucleotide binding]; other site 572264014587 salt bridge; other site 572264014588 sequence-specific DNA binding site [nucleotide binding]; other site 572264014589 Tetratricopeptide repeat; Region: TPR_12; pfam13424 572264014590 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 572264014591 TPR motif; other site 572264014592 binding surface 572264014593 TPR repeat; Region: TPR_11; pfam13414 572264014594 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 572264014595 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 572264014596 cheY-homologous receiver domain; Region: REC; smart00448 572264014597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264014598 active site 572264014599 phosphorylation site [posttranslational modification] 572264014600 intermolecular recognition site; other site 572264014601 dimerization interface [polypeptide binding]; other site 572264014602 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572264014603 DNA binding residues [nucleotide binding] 572264014604 dimerization interface [polypeptide binding]; other site 572264014605 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 572264014606 Histidine kinase; Region: HisKA_3; pfam07730 572264014607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264014608 ATP binding site [chemical binding]; other site 572264014609 Mg2+ binding site [ion binding]; other site 572264014610 G-X-G motif; other site 572264014611 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 572264014612 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 572264014613 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 572264014614 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 572264014615 Walker A/P-loop; other site 572264014616 ATP binding site [chemical binding]; other site 572264014617 Q-loop/lid; other site 572264014618 ABC transporter signature motif; other site 572264014619 Walker B; other site 572264014620 D-loop; other site 572264014621 H-loop/switch region; other site 572264014622 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 572264014623 active site 572264014624 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 572264014625 Collagen binding domain; Region: Collagen_bind; pfam05737 572264014626 Collagen binding domain; Region: Collagen_bind; pfam05737 572264014627 Collagen binding domain; Region: Collagen_bind; pfam05737 572264014628 Collagen binding domain; Region: Collagen_bind; pfam05737 572264014629 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014630 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014631 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014632 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014633 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014634 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014635 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014636 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 572264014637 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014638 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014639 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014640 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014641 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 572264014642 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014643 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014644 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014645 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014646 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014647 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014648 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 572264014649 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014650 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014651 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014652 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014653 Cna protein B-type domain; Region: Cna_B; pfam05738 572264014654 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 572264014655 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 572264014656 PA/protease or protease-like domain interface [polypeptide binding]; other site 572264014657 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 572264014658 Peptidase family M28; Region: Peptidase_M28; pfam04389 572264014659 metal binding site [ion binding]; metal-binding site 572264014660 RNA polymerase sigma factor; Provisional; Region: PRK12522 572264014661 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572264014662 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572264014663 DNA binding residues [nucleotide binding] 572264014664 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 572264014665 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 572264014666 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 572264014667 active site 572264014668 HIGH motif; other site 572264014669 KMSK motif region; other site 572264014670 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 572264014671 tRNA binding surface [nucleotide binding]; other site 572264014672 anticodon binding site; other site 572264014673 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 572264014674 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 572264014675 putative dimer interface [polypeptide binding]; other site 572264014676 catalytic triad [active] 572264014677 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 572264014678 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 572264014679 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 572264014680 agmatinase; Region: agmatinase; TIGR01230 572264014681 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 572264014682 putative active site [active] 572264014683 Mn binding site [ion binding]; other site 572264014684 spermidine synthase; Provisional; Region: PRK00811 572264014685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264014686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264014687 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572264014688 putative substrate translocation pore; other site 572264014689 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 572264014690 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 572264014691 DNA binding residues [nucleotide binding] 572264014692 putative dimer interface [polypeptide binding]; other site 572264014693 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 572264014694 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 572264014695 active site 572264014696 catalytic site [active] 572264014697 metal binding site [ion binding]; metal-binding site 572264014698 dimer interface [polypeptide binding]; other site 572264014699 Transglycosylase; Region: Transgly; pfam00912 572264014700 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 572264014701 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572264014702 YwhD family; Region: YwhD; pfam08741 572264014703 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 572264014704 Peptidase family M50; Region: Peptidase_M50; pfam02163 572264014705 active site 572264014706 putative substrate binding region [chemical binding]; other site 572264014707 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 572264014708 active site 1 [active] 572264014709 dimer interface [polypeptide binding]; other site 572264014710 hexamer interface [polypeptide binding]; other site 572264014711 active site 2 [active] 572264014712 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 572264014713 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572264014714 Zn2+ binding site [ion binding]; other site 572264014715 Mg2+ binding site [ion binding]; other site 572264014716 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 572264014717 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 572264014718 intersubunit interface [polypeptide binding]; other site 572264014719 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 572264014720 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 572264014721 Walker A/P-loop; other site 572264014722 ATP binding site [chemical binding]; other site 572264014723 Q-loop/lid; other site 572264014724 ABC transporter signature motif; other site 572264014725 Walker B; other site 572264014726 D-loop; other site 572264014727 H-loop/switch region; other site 572264014728 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 572264014729 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572264014730 ABC-ATPase subunit interface; other site 572264014731 dimer interface [polypeptide binding]; other site 572264014732 putative PBP binding regions; other site 572264014733 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 572264014734 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 572264014735 ABC-ATPase subunit interface; other site 572264014736 dimer interface [polypeptide binding]; other site 572264014737 putative PBP binding regions; other site 572264014738 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 572264014739 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 572264014740 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 572264014741 hypothetical protein; Provisional; Region: PRK12473 572264014742 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 572264014743 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 572264014744 putative heme peroxidase; Provisional; Region: PRK12276 572264014745 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 572264014746 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 572264014747 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 572264014748 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 572264014749 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 572264014750 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 572264014751 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 572264014752 Ion channel; Region: Ion_trans_2; pfam07885 572264014753 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 572264014754 TrkA-N domain; Region: TrkA_N; pfam02254 572264014755 TrkA-C domain; Region: TrkA_C; pfam02080 572264014756 putative uracil/xanthine transporter; Provisional; Region: PRK11412 572264014757 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 572264014758 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264014759 motif II; other site 572264014760 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264014761 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 572264014762 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 572264014763 ligand binding site [chemical binding]; other site 572264014764 active site 572264014765 UGI interface [polypeptide binding]; other site 572264014766 catalytic site [active] 572264014767 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 572264014768 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 572264014769 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 572264014770 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 572264014771 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 572264014772 Walker A/P-loop; other site 572264014773 ATP binding site [chemical binding]; other site 572264014774 Q-loop/lid; other site 572264014775 ABC transporter signature motif; other site 572264014776 Walker B; other site 572264014777 D-loop; other site 572264014778 H-loop/switch region; other site 572264014779 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 572264014780 active site 572264014781 catalytic triad [active] 572264014782 oxyanion hole [active] 572264014783 Transcriptional regulators [Transcription]; Region: PurR; COG1609 572264014784 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 572264014785 DNA binding site [nucleotide binding] 572264014786 domain linker motif; other site 572264014787 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 572264014788 putative dimerization interface [polypeptide binding]; other site 572264014789 putative ligand binding site [chemical binding]; other site 572264014790 Predicted membrane protein [Function unknown]; Region: COG2364 572264014791 homoserine dehydrogenase; Provisional; Region: PRK06349 572264014792 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 572264014793 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 572264014794 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 572264014795 homoserine O-succinyltransferase; Provisional; Region: PRK05368 572264014796 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 572264014797 proposed active site lysine [active] 572264014798 conserved cys residue [active] 572264014799 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 572264014800 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 572264014801 homodimer interface [polypeptide binding]; other site 572264014802 substrate-cofactor binding pocket; other site 572264014803 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572264014804 catalytic residue [active] 572264014805 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 572264014806 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572264014807 active site 572264014808 motif I; other site 572264014809 motif II; other site 572264014810 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 572264014811 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 572264014812 ligand binding site [chemical binding]; other site 572264014813 flexible hinge region; other site 572264014814 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 572264014815 azoreductase; Provisional; Region: PRK13556 572264014816 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 572264014817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264014818 active site 572264014819 phosphorylation site [posttranslational modification] 572264014820 intermolecular recognition site; other site 572264014821 dimerization interface [polypeptide binding]; other site 572264014822 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572264014823 DNA binding residues [nucleotide binding] 572264014824 dimerization interface [polypeptide binding]; other site 572264014825 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 572264014826 GAF domain; Region: GAF; pfam01590 572264014827 GAF domain; Region: GAF_3; pfam13492 572264014828 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 572264014829 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 572264014830 Histidine kinase; Region: HisKA_3; pfam07730 572264014831 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 572264014832 ATP binding site [chemical binding]; other site 572264014833 Mg2+ binding site [ion binding]; other site 572264014834 G-X-G motif; other site 572264014835 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 572264014836 dimer interface [polypeptide binding]; other site 572264014837 substrate binding site [chemical binding]; other site 572264014838 ATP binding site [chemical binding]; other site 572264014839 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 572264014840 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572264014841 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572264014842 metal binding site [ion binding]; metal-binding site 572264014843 active site 572264014844 I-site; other site 572264014845 Protein of unknown function (DUF466); Region: DUF466; pfam04328 572264014846 carbon starvation protein A; Provisional; Region: PRK15015 572264014847 Carbon starvation protein CstA; Region: CstA; pfam02554 572264014848 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 572264014849 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 572264014850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264014851 active site 572264014852 phosphorylation site [posttranslational modification] 572264014853 intermolecular recognition site; other site 572264014854 dimerization interface [polypeptide binding]; other site 572264014855 LytTr DNA-binding domain; Region: LytTR; pfam04397 572264014856 benzoate transport; Region: 2A0115; TIGR00895 572264014857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264014858 putative substrate translocation pore; other site 572264014859 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 572264014860 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 572264014861 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572264014862 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 572264014863 Predicted membrane protein [Function unknown]; Region: COG2860 572264014864 UPF0126 domain; Region: UPF0126; pfam03458 572264014865 UPF0126 domain; Region: UPF0126; pfam03458 572264014866 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 572264014867 heme-binding site [chemical binding]; other site 572264014868 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 572264014869 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 572264014870 dimer interface [polypeptide binding]; other site 572264014871 putative CheW interface [polypeptide binding]; other site 572264014872 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 572264014873 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 572264014874 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 572264014875 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 572264014876 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 572264014877 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 572264014878 active site 572264014879 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 572264014880 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264014881 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264014882 ABC transporter; Region: ABC_tran_2; pfam12848 572264014883 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572264014884 conserved hypothetical integral membrane protein; Region: TIGR03766 572264014885 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 572264014886 Predicted membrane protein [Function unknown]; Region: COG2246 572264014887 GtrA-like protein; Region: GtrA; pfam04138 572264014888 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 572264014889 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 572264014890 Ligand binding site; other site 572264014891 Putative Catalytic site; other site 572264014892 DXD motif; other site 572264014893 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572264014894 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572264014895 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 572264014896 Protein export membrane protein; Region: SecD_SecF; cl14618 572264014897 methionine sulfoxide reductase A; Provisional; Region: PRK14054 572264014898 methionine sulfoxide reductase B; Provisional; Region: PRK00222 572264014899 SelR domain; Region: SelR; pfam01641 572264014900 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 572264014901 antiholin-like protein LrgB; Provisional; Region: PRK04288 572264014902 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 572264014903 two-component response regulator; Provisional; Region: PRK14084 572264014904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264014905 active site 572264014906 phosphorylation site [posttranslational modification] 572264014907 intermolecular recognition site; other site 572264014908 dimerization interface [polypeptide binding]; other site 572264014909 LytTr DNA-binding domain; Region: LytTR; pfam04397 572264014910 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 572264014911 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 572264014912 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 572264014913 Histidine kinase; Region: His_kinase; pfam06580 572264014914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264014915 ATP binding site [chemical binding]; other site 572264014916 Mg2+ binding site [ion binding]; other site 572264014917 G-X-G motif; other site 572264014918 PyrR binding site 572264014919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572264014920 benzoate transport; Region: 2A0115; TIGR00895 572264014921 putative substrate translocation pore; other site 572264014922 BCCT family transporter; Region: BCCT; pfam02028 572264014923 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 572264014924 active site 572264014925 dimer interface [polypeptide binding]; other site 572264014926 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 572264014927 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 572264014928 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 572264014929 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 572264014930 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572264014931 NAD(P) binding site [chemical binding]; other site 572264014932 active site 572264014933 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 572264014934 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 572264014935 UDP-glucose 4-epimerase; Region: PLN02240 572264014936 NAD binding site [chemical binding]; other site 572264014937 homodimer interface [polypeptide binding]; other site 572264014938 active site 572264014939 substrate binding site [chemical binding]; other site 572264014940 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 572264014941 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 572264014942 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 572264014943 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 572264014944 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 572264014945 ATP binding site [chemical binding]; other site 572264014946 Mg++ binding site [ion binding]; other site 572264014947 motif III; other site 572264014948 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572264014949 nucleotide binding region [chemical binding]; other site 572264014950 ATP-binding site [chemical binding]; other site 572264014951 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 572264014952 RNA binding site [nucleotide binding]; other site 572264014953 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 572264014954 Acyltransferase family; Region: Acyl_transf_3; pfam01757 572264014955 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 572264014956 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 572264014957 active site 572264014958 oligoendopeptidase F; Region: pepF; TIGR00181 572264014959 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 572264014960 active site 572264014961 Zn binding site [ion binding]; other site 572264014962 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572264014963 FeS/SAM binding site; other site 572264014964 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 572264014965 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 572264014966 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 572264014967 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 572264014968 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 572264014969 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 572264014970 protein binding site [polypeptide binding]; other site 572264014971 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 572264014972 YycH protein; Region: YycI; pfam09648 572264014973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 572264014974 YycH protein; Region: YycH; pfam07435 572264014975 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 572264014976 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 572264014977 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572264014978 dimerization interface [polypeptide binding]; other site 572264014979 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572264014980 putative active site [active] 572264014981 heme pocket [chemical binding]; other site 572264014982 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572264014983 dimer interface [polypeptide binding]; other site 572264014984 phosphorylation site [posttranslational modification] 572264014985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572264014986 ATP binding site [chemical binding]; other site 572264014987 Mg2+ binding site [ion binding]; other site 572264014988 G-X-G motif; other site 572264014989 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572264014990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572264014991 active site 572264014992 phosphorylation site [posttranslational modification] 572264014993 intermolecular recognition site; other site 572264014994 dimerization interface [polypeptide binding]; other site 572264014995 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572264014996 DNA binding site [nucleotide binding] 572264014997 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 572264014998 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 572264014999 GDP-binding site [chemical binding]; other site 572264015000 ACT binding site; other site 572264015001 IMP binding site; other site 572264015002 replicative DNA helicase; Provisional; Region: PRK05748 572264015003 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 572264015004 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 572264015005 Walker A motif; other site 572264015006 ATP binding site [chemical binding]; other site 572264015007 Walker B motif; other site 572264015008 DNA binding loops [nucleotide binding] 572264015009 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 572264015010 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 572264015011 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 572264015012 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 572264015013 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 572264015014 DHH family; Region: DHH; pfam01368 572264015015 DHHA1 domain; Region: DHHA1; pfam02272 572264015016 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 572264015017 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 572264015018 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 572264015019 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 572264015020 dimer interface [polypeptide binding]; other site 572264015021 ssDNA binding site [nucleotide binding]; other site 572264015022 tetramer (dimer of dimers) interface [polypeptide binding]; other site 572264015023 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 572264015024 GTP-binding protein YchF; Reviewed; Region: PRK09601 572264015025 YchF GTPase; Region: YchF; cd01900 572264015026 G1 box; other site 572264015027 GTP/Mg2+ binding site [chemical binding]; other site 572264015028 Switch I region; other site 572264015029 G2 box; other site 572264015030 Switch II region; other site 572264015031 G3 box; other site 572264015032 G4 box; other site 572264015033 G5 box; other site 572264015034 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 572264015035 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 572264015036 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 572264015037 Mechanosensitive ion channel; Region: MS_channel; pfam00924 572264015038 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 572264015039 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 572264015040 ParB-like nuclease domain; Region: ParB; smart00470 572264015041 KorB domain; Region: KorB; pfam08535 572264015042 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 572264015043 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 572264015044 P-loop; other site 572264015045 Magnesium ion binding site [ion binding]; other site 572264015046 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 572264015047 Magnesium ion binding site [ion binding]; other site 572264015048 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 572264015049 ParB-like nuclease domain; Region: ParBc; pfam02195 572264015050 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 572264015051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264015052 S-adenosylmethionine binding site [chemical binding]; other site 572264015053 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 572264015054 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 572264015055 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 572264015056 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 572264015057 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 572264015058 trmE is a tRNA modification GTPase; Region: trmE; cd04164 572264015059 G1 box; other site 572264015060 GTP/Mg2+ binding site [chemical binding]; other site 572264015061 Switch I region; other site 572264015062 G2 box; other site 572264015063 Switch II region; other site 572264015064 G3 box; other site 572264015065 G4 box; other site 572264015066 G5 box; other site 572264015067 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 572264015068 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 572264015069 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 572264015070 G-X-X-G motif; other site 572264015071 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 572264015072 RxxxH motif; other site 572264015073 OxaA-like protein precursor; Validated; Region: PRK02944 572264015074 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 572264015075 ribonuclease P; Reviewed; Region: rnpA; PRK00499 572264015076 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 572264015077 Nuclease-related domain; Region: NERD; pfam08378 572264015078 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 572264015079 ATP binding site [chemical binding]; other site 572264015080 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572264015081 nucleotide binding region [chemical binding]; other site 572264015082 ATP-binding site [chemical binding]; other site 572264015083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572264015084 S-adenosylmethionine binding site [chemical binding]; other site 572264015085 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572264015086 sequence-specific DNA binding site [nucleotide binding]; other site 572264015087 salt bridge; other site 572264015088 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 572264015089 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 572264015090 active site 572264015091 Int/Topo IB signature motif; other site 572264015092 catalytic residues [active] 572264015093 DNA binding site [nucleotide binding] 572264015094 HNH endonuclease; Region: HNH_5; pfam14279 572264015095 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 572264015096 HEPN domain; Region: HEPN; pfam05168 572264015097 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 572264015098 active site 572264015099 NTP binding site [chemical binding]; other site 572264015100 metal binding triad [ion binding]; metal-binding site 572264015101 antibiotic binding site [chemical binding]; other site 572264015102 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 572264015103 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 572264015104 Predicted integral membrane protein [Function unknown]; Region: COG5658 572264015105 SdpI/YhfL protein family; Region: SdpI; pfam13630 572264015106 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264015107 dimerization interface [polypeptide binding]; other site 572264015108 putative DNA binding site [nucleotide binding]; other site 572264015109 putative Zn2+ binding site [ion binding]; other site 572264015110 Domain of unknown function (DUF373); Region: DUF373; cl12079 572264015111 AAA-like domain; Region: AAA_10; pfam12846 572264015112 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 572264015113 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 572264015114 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 572264015115 Replication-relaxation; Region: Replic_Relax; pfam13814 572264015116 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 572264015117 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 572264015118 DNA binding residues [nucleotide binding] 572264015119 Transposase; Region: HTH_Tnp_1; pfam01527 572264015120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 572264015121 HTH-like domain; Region: HTH_21; pfam13276 572264015122 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 572264015123 Integrase core domain; Region: rve; pfam00665 572264015124 Integrase core domain; Region: rve_2; pfam13333 572264015125 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 572264015126 S-layer homology domain; Region: SLH; pfam00395 572264015127 S-layer homology domain; Region: SLH; pfam00395 572264015128 S-layer homology domain; Region: SLH; pfam00395 572264015129 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 572264015130 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 572264015131 AAA domain; Region: AAA_31; pfam13614 572264015132 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 572264015133 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 572264015134 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 572264015135 Walker A motif; other site 572264015136 ATP binding site [chemical binding]; other site 572264015137 Walker B motif; other site 572264015138 WxL domain surface cell wall-binding; Region: WxL; pfam13731 572264015139 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 572264015140 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 572264015141 WxL domain surface cell wall-binding; Region: WxL; pfam13731 572264015142 ARID/BRIGHT DNA binding domain; Region: ARID; cl02633 572264015143 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 572264015144 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 572264015145 active site 572264015146 metal binding site [ion binding]; metal-binding site 572264015147 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 572264015148 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 572264015149 PrgI family protein; Region: PrgI; pfam12666 572264015150 AAA-like domain; Region: AAA_10; pfam12846 572264015151 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 572264015152 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 572264015153 N-acetyl-D-glucosamine binding site [chemical binding]; other site 572264015154 catalytic residue [active] 572264015155 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 572264015156 Peptidase family M23; Region: Peptidase_M23; pfam01551 572264015157 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 572264015158 NlpC/P60 family; Region: NLPC_P60; pfam00877 572264015159 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 572264015160 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 572264015161 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 572264015162 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 572264015163 putative active site [active] 572264015164 putative metal binding site [ion binding]; other site 572264015165 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 572264015166 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 572264015167 Predicted membrane protein [Function unknown]; Region: COG2311 572264015168 Protein of unknown function (DUF418); Region: DUF418; cl12135 572264015169 Protein of unknown function (DUF418); Region: DUF418; pfam04235 572264015170 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 572264015171 catalytic residues [active] 572264015172 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 572264015173 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 572264015174 Probable transposase; Region: OrfB_IS605; pfam01385 572264015175 Probable transposase; Region: OrfB_IS605; pfam01385 572264015176 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 572264015177 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 572264015178 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 572264015179 heme-binding site [chemical binding]; other site 572264015180 S-layer homology domain; Region: SLH; pfam00395 572264015181 S-layer homology domain; Region: SLH; pfam00395 572264015182 S-layer homology domain; Region: SLH; pfam00395 572264015183 Acetokinase family; Region: Acetate_kinase; cl17229 572264015184 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 572264015185 active site 572264015186 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 572264015187 chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242 572264015188 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 572264015189 active site 572264015190 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 572264015191 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 572264015192 active site 572264015193 tetramer interface; other site 572264015194 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 572264015195 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 572264015196 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 572264015197 putative transposase OrfB; Reviewed; Region: PHA02517 572264015198 HTH-like domain; Region: HTH_21; pfam13276 572264015199 Integrase core domain; Region: rve; pfam00665 572264015200 Integrase core domain; Region: rve_3; pfam13683 572264015201 Integrase core domain; Region: rve; pfam00665 572264015202 Anthrax toxin lethal factor, N- and C-terminal domain; Region: ATLF; pfam07737 572264015203 Anthrax toxin LF subunit; Region: Anthrax_toxA; pfam03497 572264015204 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572264015205 active site 572264015206 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 572264015207 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 572264015208 Transposase domain (DUF772); Region: DUF772; pfam05598 572264015209 HTH domain; Region: HTH_11; cl17392 572264015210 Mga helix-turn-helix domain; Region: Mga; pfam05043 572264015211 PRD domain; Region: PRD; pfam00874 572264015212 PRD domain; Region: PRD; pfam00874 572264015213 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 572264015214 Histidine kinase N terminal; Region: HisK_N; pfam09385 572264015215 Histidine kinase N terminal; Region: HisK_N; pfam09385 572264015216 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572264015217 active site 572264015218 Endonuclease I; Region: Endonuclease_1; pfam04231 572264015219 PA14 domain; Region: PA14; pfam07691 572264015220 Clostridial binary toxin B/anthrax toxin PA; Region: Binary_toxB; pfam03495 572264015221 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 572264015222 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264015223 dimerization interface [polypeptide binding]; other site 572264015224 putative DNA binding site [nucleotide binding]; other site 572264015225 putative Zn2+ binding site [ion binding]; other site 572264015226 Anthrax toxin lethal factor, N- and C-terminal domain; Region: ATLF; pfam07737 572264015227 PA14 domain; Region: PA14; pfam07691 572264015228 Clostridial binary toxin B/anthrax toxin PA; Region: Binary_toxB; pfam03495 572264015229 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264015230 dimerization interface [polypeptide binding]; other site 572264015231 putative DNA binding site [nucleotide binding]; other site 572264015232 putative Zn2+ binding site [ion binding]; other site 572264015233 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 572264015234 Anthrax toxin lethal factor, N- and C-terminal domain; Region: ATLF; pfam07737 572264015235 Anthrax toxin lethal factor, middle domain; Region: Anthrax-tox_M; pfam09156 572264015236 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 572264015237 active site 572264015238 conformational flexibility of ligand binding pocket; other site 572264015239 ADP-ribosylating toxin turn-turn motif; other site 572264015240 Anthrax toxin lethal factor, N- and C-terminal domain; Region: ATLF; pfam07737 572264015241 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 572264015242 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 572264015243 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 572264015244 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 572264015245 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 572264015246 active site 572264015247 Int/Topo IB signature motif; other site 572264015248 DNA binding site [nucleotide binding] 572264015249 Helix-turn-helix domain; Region: HTH_17; pfam12728 572264015250 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 572264015251 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 572264015252 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 572264015253 Integrase core domain; Region: rve; pfam00665 572264015254 Integrase core domain; Region: rve_2; pfam13333 572264015255 Winged helix-turn helix; Region: HTH_29; pfam13551 572264015256 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 572264015257 HTH-like domain; Region: HTH_21; pfam13276 572264015258 Integrase core domain; Region: rve; pfam00665 572264015259 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 572264015260 Homeodomain-like domain; Region: HTH_23; cl17451 572264015261 Homeodomain-like domain; Region: HTH_23; cl17451 572264015262 HTH-like domain; Region: HTH_21; pfam13276 572264015263 Integrase core domain; Region: rve; pfam00665 572264015264 Integrase core domain; Region: rve; pfam00665 572264015265 Integrase core domain; Region: rve_2; pfam13333 572264015266 YodA lipocalin-like domain; Region: YodA; pfam09223 572264015267 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 572264015268 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 572264015269 active site 572264015270 DNA binding site [nucleotide binding] 572264015271 Int/Topo IB signature motif; other site 572264015272 Part of AAA domain; Region: AAA_19; pfam13245 572264015273 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 572264015274 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 572264015275 Family description; Region: UvrD_C_2; pfam13538 572264015276 AAA ATPase domain; Region: AAA_15; pfam13175 572264015277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572264015278 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 572264015279 G1 box; other site 572264015280 Walker A/P-loop; other site 572264015281 GTP/Mg2+ binding site [chemical binding]; other site 572264015282 ATP binding site [chemical binding]; other site 572264015283 G2 box; other site 572264015284 Switch I region; other site 572264015285 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 572264015286 putative active site [active] 572264015287 putative metal-binding site [ion binding]; other site 572264015288 Competence protein CoiA-like family; Region: CoiA; cl11541 572264015289 LXG domain of WXG superfamily; Region: LXG; pfam04740 572264015290 bacterial Hfq-like; Region: Hfq; cd01716 572264015291 hexamer interface [polypeptide binding]; other site 572264015292 Sm1 motif; other site 572264015293 RNA binding site [nucleotide binding]; other site 572264015294 Sm2 motif; other site 572264015295 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572264015296 dimerization interface [polypeptide binding]; other site 572264015297 putative DNA binding site [nucleotide binding]; other site 572264015298 putative Zn2+ binding site [ion binding]; other site 572264015299 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 572264015300 Staphylococcal nuclease homologues; Region: SNc; smart00318 572264015301 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 572264015302 Catalytic site; other site 572264015303 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342