-- dump date 20140618_214129 -- class Genbank::misc_feature -- table misc_feature_note -- id note 405534000001 Replication initiation factor; Region: Rep_trans; pfam02486 405534000002 Zonular occludens toxin (Zot); Region: Zot; cl17485 405534000003 Fibronectin type 3 domain; Region: FN3; smart00060 405534000004 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405534000005 Interdomain contacts; other site 405534000006 Cytokine receptor motif; other site 405534000007 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405534000008 Interdomain contacts; other site 405534000009 Cytokine receptor motif; other site 405534000010 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534000011 putative DNA binding site [nucleotide binding]; other site 405534000012 putative Zn2+ binding site [ion binding]; other site 405534000013 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 405534000014 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 405534000015 Helix-turn-helix domain; Region: HTH_38; pfam13936 405534000016 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 405534000017 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 405534000018 active site 405534000019 catalytic residues [active] 405534000020 DNA binding site [nucleotide binding] 405534000021 Int/Topo IB signature motif; other site 405534000022 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 405534000023 Active Sites [active] 405534000024 HEPN domain; Region: HEPN; pfam05168 405534000025 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 405534000026 active site 405534000027 NTP binding site [chemical binding]; other site 405534000028 metal binding triad [ion binding]; metal-binding site 405534000029 antibiotic binding site [chemical binding]; other site 405534000030 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 405534000031 ATP binding site [chemical binding]; other site 405534000032 substrate interface [chemical binding]; other site 405534000033 PRTRC system protein A; Region: PRTRC_A; TIGR03735 405534000034 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 405534000035 Prokaryotic E2 family D; Region: Prok-E2_D; cl14019 405534000036 DNA polymerase III subunit beta; Validated; Region: PRK05643 405534000037 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 405534000038 putative DNA binding surface [nucleotide binding]; other site 405534000039 dimer interface [polypeptide binding]; other site 405534000040 beta-clamp/clamp loader binding surface; other site 405534000041 beta-clamp/translesion DNA polymerase binding surface; other site 405534000042 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 405534000043 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 405534000044 putative active site [active] 405534000045 putative NTP binding site [chemical binding]; other site 405534000046 putative nucleic acid binding site [nucleotide binding]; other site 405534000047 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 405534000048 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 405534000049 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 405534000050 active site 405534000051 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 405534000052 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 405534000053 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 405534000054 putative active site [active] 405534000055 putative NTP binding site [chemical binding]; other site 405534000056 putative nucleic acid binding site [nucleotide binding]; other site 405534000057 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 405534000058 Domain of unknown function (DUF373); Region: DUF373; cl12079 405534000059 AAA-like domain; Region: AAA_10; pfam12846 405534000060 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 405534000061 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 405534000062 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 405534000063 Replication-relaxation; Region: Replic_Relax; pfam13814 405534000064 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 405534000065 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 405534000066 DNA binding residues [nucleotide binding] 405534000067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405534000068 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 405534000069 Probable transposase; Region: OrfB_IS605; pfam01385 405534000070 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405534000071 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 405534000072 S-layer homology domain; Region: SLH; pfam00395 405534000073 S-layer homology domain; Region: SLH; pfam00395 405534000074 S-layer homology domain; Region: SLH; pfam00395 405534000075 HTH-like domain; Region: HTH_21; pfam13276 405534000076 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 405534000077 Integrase core domain; Region: rve; pfam00665 405534000078 Integrase core domain; Region: rve_2; pfam13333 405534000079 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405534000080 Helix-turn-helix domain; Region: HTH_28; pfam13518 405534000081 Helix-turn-helix domain; Region: HTH_28; pfam13518 405534000082 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 405534000083 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 405534000084 AAA domain; Region: AAA_31; pfam13614 405534000085 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 405534000086 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 405534000087 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 405534000088 Walker A motif; other site 405534000089 ATP binding site [chemical binding]; other site 405534000090 Walker B motif; other site 405534000091 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405534000092 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 405534000093 Probable transposase; Region: OrfB_IS605; pfam01385 405534000094 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405534000095 WxL domain surface cell wall-binding; Region: WxL; pfam13731 405534000096 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 405534000097 active site 405534000098 catalytic site [active] 405534000099 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 405534000100 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 405534000101 Recombination protein U; Region: RecU; cl01314 405534000102 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 405534000103 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405534000104 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405534000105 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 405534000106 catalytic residues [active] 405534000107 catalytic nucleophile [active] 405534000108 Presynaptic Site I dimer interface [polypeptide binding]; other site 405534000109 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 405534000110 Synaptic Flat tetramer interface [polypeptide binding]; other site 405534000111 Synaptic Site I dimer interface [polypeptide binding]; other site 405534000112 DNA binding site [nucleotide binding] 405534000113 S-layer homology domain; Region: SLH; pfam00395 405534000114 S-layer homology domain; Region: SLH; pfam00395 405534000115 S-layer homology domain; Region: SLH; pfam00395 405534000116 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 405534000117 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 405534000118 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 405534000119 active site 405534000120 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 405534000121 RNAase interaction site [polypeptide binding]; other site 405534000122 ARID/BRIGHT DNA binding domain; Region: ARID; cl02633 405534000123 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 405534000124 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 405534000125 active site 405534000126 metal binding site [ion binding]; metal-binding site 405534000127 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 405534000128 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 405534000129 PrgI family protein; Region: PrgI; pfam12666 405534000130 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 405534000131 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 405534000132 putative active site [active] 405534000133 putative NTP binding site [chemical binding]; other site 405534000134 putative nucleic acid binding site [nucleotide binding]; other site 405534000135 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 405534000136 active site 405534000137 AAA-like domain; Region: AAA_10; pfam12846 405534000138 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 405534000139 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 405534000140 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405534000141 catalytic residue [active] 405534000142 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405534000143 Peptidase family M23; Region: Peptidase_M23; pfam01551 405534000144 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405534000145 NlpC/P60 family; Region: NLPC_P60; pfam00877 405534000146 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 405534000147 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 405534000148 CAAX protease self-immunity; Region: Abi; pfam02517 405534000149 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405534000150 Predicted membrane protein [Function unknown]; Region: COG2311 405534000151 Protein of unknown function (DUF418); Region: DUF418; cl12135 405534000152 Protein of unknown function (DUF418); Region: DUF418; pfam04235 405534000153 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405534000154 catalytic residues [active] 405534000155 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 405534000156 IHF dimer interface [polypeptide binding]; other site 405534000157 IHF - DNA interface [nucleotide binding]; other site 405534000158 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 405534000159 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 405534000160 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405534000161 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534000162 non-specific DNA binding site [nucleotide binding]; other site 405534000163 salt bridge; other site 405534000164 sequence-specific DNA binding site [nucleotide binding]; other site 405534000165 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405534000166 active site 405534000167 Int/Topo IB signature motif; other site 405534000168 DNA binding site [nucleotide binding] 405534000169 Helix-turn-helix domain; Region: HTH_17; pfam12728 405534000170 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 405534000171 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 405534000172 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 405534000173 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 405534000174 Spindle pole body interacting protein; Region: SPB_interacting; pfam08616 405534000175 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534000176 dimerization interface [polypeptide binding]; other site 405534000177 putative DNA binding site [nucleotide binding]; other site 405534000178 putative Zn2+ binding site [ion binding]; other site 405534000179 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 405534000180 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 405534000181 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 405534000182 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 405534000183 multiple promoter invertase; Provisional; Region: mpi; PRK13413 405534000184 catalytic residues [active] 405534000185 catalytic nucleophile [active] 405534000186 Presynaptic Site I dimer interface [polypeptide binding]; other site 405534000187 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 405534000188 Synaptic Flat tetramer interface [polypeptide binding]; other site 405534000189 Synaptic Site I dimer interface [polypeptide binding]; other site 405534000190 DNA binding site [nucleotide binding] 405534000191 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 405534000192 DNA-binding interface [nucleotide binding]; DNA binding site 405534000193 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405534000194 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405534000195 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 405534000196 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405534000197 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 405534000198 Presynaptic Site I dimer interface [polypeptide binding]; other site 405534000199 catalytic residues [active] 405534000200 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 405534000201 Synaptic Flat tetramer interface [polypeptide binding]; other site 405534000202 Synaptic Site I dimer interface [polypeptide binding]; other site 405534000203 DNA binding site [nucleotide binding] 405534000204 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 405534000205 DNA-binding interface [nucleotide binding]; DNA binding site 405534000206 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 405534000207 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405534000208 active site 405534000209 metal binding site [ion binding]; metal-binding site 405534000210 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405534000211 catalytic core [active] 405534000212 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 405534000213 Integrase core domain; Region: rve; pfam00665 405534000214 transposase/IS protein; Provisional; Region: PRK09183 405534000215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534000216 Walker A motif; other site 405534000217 ATP binding site [chemical binding]; other site 405534000218 Walker B motif; other site 405534000219 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405534000220 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 405534000221 DNA-binding interface [nucleotide binding]; DNA binding site 405534000222 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 405534000223 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405534000224 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534000225 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405534000226 active site 405534000227 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 405534000228 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 405534000229 multiple promoter invertase; Provisional; Region: mpi; PRK13413 405534000230 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 405534000231 catalytic residues [active] 405534000232 catalytic nucleophile [active] 405534000233 Presynaptic Site I dimer interface [polypeptide binding]; other site 405534000234 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 405534000235 Synaptic Flat tetramer interface [polypeptide binding]; other site 405534000236 Synaptic Site I dimer interface [polypeptide binding]; other site 405534000237 DNA binding site [nucleotide binding] 405534000238 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 405534000239 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534000240 salt bridge; other site 405534000241 non-specific DNA binding site [nucleotide binding]; other site 405534000242 sequence-specific DNA binding site [nucleotide binding]; other site 405534000243 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405534000244 Predicted membrane protein [Function unknown]; Region: COG2323 405534000245 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 405534000246 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 405534000247 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405534000248 putative active site [active] 405534000249 catalytic site [active] 405534000250 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 405534000251 putative active site [active] 405534000252 catalytic site [active] 405534000253 Predicted membrane protein [Function unknown]; Region: COG2323 405534000254 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 405534000255 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 405534000256 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 405534000257 stage V sporulation protein AD; Provisional; Region: PRK12404 405534000258 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 405534000259 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 405534000260 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 405534000261 Predicted membrane protein [Function unknown]; Region: COG2323 405534000262 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 405534000263 Clp protease; Region: CLP_protease; pfam00574 405534000264 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 405534000265 oligomer interface [polypeptide binding]; other site 405534000266 active site residues [active] 405534000267 multiple promoter invertase; Provisional; Region: mpi; PRK13413 405534000268 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 405534000269 catalytic residues [active] 405534000270 catalytic nucleophile [active] 405534000271 Presynaptic Site I dimer interface [polypeptide binding]; other site 405534000272 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 405534000273 Synaptic Flat tetramer interface [polypeptide binding]; other site 405534000274 Synaptic Site I dimer interface [polypeptide binding]; other site 405534000275 DNA binding site [nucleotide binding] 405534000276 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 405534000277 DNA-binding interface [nucleotide binding]; DNA binding site 405534000278 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405534000279 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405534000280 Spore germination protein; Region: Spore_permease; cl17796 405534000281 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405534000282 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 405534000283 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 405534000284 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 405534000285 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 405534000286 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 405534000287 Predicted transcriptional regulators [Transcription]; Region: COG1733 405534000288 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 405534000289 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 405534000290 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 405534000291 substrate binding site [chemical binding]; other site 405534000292 catalytic Zn binding site [ion binding]; other site 405534000293 NAD binding site [chemical binding]; other site 405534000294 structural Zn binding site [ion binding]; other site 405534000295 dimer interface [polypeptide binding]; other site 405534000296 S-formylglutathione hydrolase; Region: PLN02442 405534000297 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 405534000298 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 405534000299 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 405534000300 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 405534000301 ATP-grasp domain; Region: ATP-grasp_4; cl17255 405534000302 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405534000303 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405534000304 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405534000305 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405534000306 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405534000307 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000308 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000309 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000310 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000311 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000312 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000313 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000314 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000315 Domain of unknown function DUF11; Region: DUF11; cl17728 405534000316 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000317 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000318 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000319 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000320 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000321 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000322 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000323 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000324 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000325 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000326 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000327 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000328 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000329 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000330 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000331 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000332 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000333 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000334 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000335 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000336 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534000337 Isochorismatase family; Region: Isochorismatase; pfam00857 405534000338 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 405534000339 catalytic triad [active] 405534000340 conserved cis-peptide bond; other site 405534000341 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 405534000342 putative active site [active] 405534000343 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534000344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534000345 active site 405534000346 phosphorylation site [posttranslational modification] 405534000347 intermolecular recognition site; other site 405534000348 dimerization interface [polypeptide binding]; other site 405534000349 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534000350 DNA binding site [nucleotide binding] 405534000351 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534000352 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534000353 dimerization interface [polypeptide binding]; other site 405534000354 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534000355 dimer interface [polypeptide binding]; other site 405534000356 phosphorylation site [posttranslational modification] 405534000357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534000358 ATP binding site [chemical binding]; other site 405534000359 Mg2+ binding site [ion binding]; other site 405534000360 G-X-G motif; other site 405534000361 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 405534000362 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 405534000363 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 405534000364 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 405534000365 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 405534000366 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405534000367 active site 405534000368 DNA binding site [nucleotide binding] 405534000369 Int/Topo IB signature motif; other site 405534000370 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405534000371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405534000372 TPR motif; other site 405534000373 binding surface 405534000374 bacterial Hfq-like; Region: Hfq; cd01716 405534000375 hexamer interface [polypeptide binding]; other site 405534000376 Sm1 motif; other site 405534000377 RNA binding site [nucleotide binding]; other site 405534000378 Sm2 motif; other site 405534000379 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534000380 dimerization interface [polypeptide binding]; other site 405534000381 putative DNA binding site [nucleotide binding]; other site 405534000382 putative Zn2+ binding site [ion binding]; other site 405534000383 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 405534000384 Staphylococcal nuclease homologues; Region: SNc; smart00318 405534000385 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 405534000386 Catalytic site; other site 405534000387 DNA topoisomerase III; Provisional; Region: PRK07726 405534000388 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 405534000389 active site 405534000390 putative interdomain interaction site [polypeptide binding]; other site 405534000391 putative metal-binding site [ion binding]; other site 405534000392 putative nucleotide binding site [chemical binding]; other site 405534000393 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 405534000394 domain I; other site 405534000395 DNA binding groove [nucleotide binding] 405534000396 phosphate binding site [ion binding]; other site 405534000397 domain II; other site 405534000398 domain III; other site 405534000399 nucleotide binding site [chemical binding]; other site 405534000400 catalytic site [active] 405534000401 domain IV; other site 405534000402 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 405534000403 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 405534000404 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 405534000405 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 405534000406 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 405534000407 Nuclease-related domain; Region: NERD; pfam08378 405534000408 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 405534000409 ATP binding site [chemical binding]; other site 405534000410 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405534000411 nucleotide binding region [chemical binding]; other site 405534000412 ATP-binding site [chemical binding]; other site 405534000413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534000414 S-adenosylmethionine binding site [chemical binding]; other site 405534000415 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 405534000416 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 405534000417 putative active site [active] 405534000418 putative NTP binding site [chemical binding]; other site 405534000419 putative nucleic acid binding site [nucleotide binding]; other site 405534000420 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 405534000421 active site 405534000422 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405534000423 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405534000424 Walker A/P-loop; other site 405534000425 ATP binding site [chemical binding]; other site 405534000426 Q-loop/lid; other site 405534000427 ABC transporter signature motif; other site 405534000428 Walker B; other site 405534000429 D-loop; other site 405534000430 H-loop/switch region; other site 405534000431 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405534000432 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 405534000433 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 405534000434 acyl-activating enzyme (AAE) consensus motif; other site 405534000435 putative AMP binding site [chemical binding]; other site 405534000436 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 405534000437 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 405534000438 putative NADP binding site [chemical binding]; other site 405534000439 active site 405534000440 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405534000441 Condensation domain; Region: Condensation; pfam00668 405534000442 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 405534000443 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 405534000444 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 405534000445 acyl-activating enzyme (AAE) consensus motif; other site 405534000446 AMP binding site [chemical binding]; other site 405534000447 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405534000448 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 405534000449 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 405534000450 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 405534000451 acyl-activating enzyme (AAE) consensus motif; other site 405534000452 putative AMP binding site [chemical binding]; other site 405534000453 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 405534000454 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 405534000455 putative NADP binding site [chemical binding]; other site 405534000456 active site 405534000457 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405534000458 Condensation domain; Region: Condensation; pfam00668 405534000459 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 405534000460 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 405534000461 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405534000462 acyl-activating enzyme (AAE) consensus motif; other site 405534000463 AMP binding site [chemical binding]; other site 405534000464 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405534000465 Condensation domain; Region: Condensation; pfam00668 405534000466 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 405534000467 Condensation domain; Region: Condensation; pfam00668 405534000468 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 405534000469 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405534000470 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 405534000471 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 405534000472 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 405534000473 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 405534000474 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405534000475 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534000476 non-specific DNA binding site [nucleotide binding]; other site 405534000477 sequence-specific DNA binding site [nucleotide binding]; other site 405534000478 salt bridge; other site 405534000479 CAAX protease self-immunity; Region: Abi; pfam02517 405534000480 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534000481 dimerization interface [polypeptide binding]; other site 405534000482 putative DNA binding site [nucleotide binding]; other site 405534000483 putative Zn2+ binding site [ion binding]; other site 405534000484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 405534000485 Chitin binding domain; Region: Chitin_bind_3; pfam03067 405534000486 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405534000487 Interdomain contacts; other site 405534000488 Cytokine receptor motif; other site 405534000489 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 405534000490 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405534000491 Interdomain contacts; other site 405534000492 Cytokine receptor motif; other site 405534000493 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 405534000494 aromatic chitin/cellulose binding site residues [chemical binding]; other site 405534000495 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 405534000496 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405534000497 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405534000498 putative CheW interface [polypeptide binding]; other site 405534000499 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405534000500 PAS domain; Region: PAS_9; pfam13426 405534000501 putative active site [active] 405534000502 heme pocket [chemical binding]; other site 405534000503 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405534000504 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405534000505 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 405534000506 active site 405534000507 Zn binding site [ion binding]; other site 405534000508 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 405534000509 putative active site [active] 405534000510 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405534000511 NlpC/P60 family; Region: NLPC_P60; pfam00877 405534000512 TIR domain; Region: TIR_2; pfam13676 405534000513 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405534000514 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534000515 non-specific DNA binding site [nucleotide binding]; other site 405534000516 salt bridge; other site 405534000517 sequence-specific DNA binding site [nucleotide binding]; other site 405534000518 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534000519 sequence-specific DNA binding site [nucleotide binding]; other site 405534000520 salt bridge; other site 405534000521 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534000522 non-specific DNA binding site [nucleotide binding]; other site 405534000523 salt bridge; other site 405534000524 sequence-specific DNA binding site [nucleotide binding]; other site 405534000525 TQXA domain; Region: TQXA_dom; TIGR03934 405534000526 Cna protein B-type domain; Region: Cna_B; pfam05738 405534000527 Cna protein B-type domain; Region: Cna_B; pfam05738 405534000528 Cna protein B-type domain; Region: Cna_B; pfam05738 405534000529 Cna protein B-type domain; Region: Cna_B; pfam05738 405534000530 Cna protein B-type domain; Region: Cna_B; pfam05738 405534000531 AAA-like domain; Region: AAA_10; pfam12846 405534000532 Replication-relaxation; Region: Replic_Relax; pfam13814 405534000533 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 405534000534 TcpE family; Region: TcpE; pfam12648 405534000535 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 405534000536 AAA-like domain; Region: AAA_10; pfam12846 405534000537 Walker A motif; other site 405534000538 ATP binding site [chemical binding]; other site 405534000539 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 405534000540 signal recognition particle protein; Provisional; Region: PRK10867 405534000541 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 405534000542 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405534000543 Peptidase family M23; Region: Peptidase_M23; pfam01551 405534000544 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 405534000545 Caspase domain; Region: Peptidase_C14; pfam00656 405534000546 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 405534000547 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 405534000548 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405534000549 active site 405534000550 DNA binding site [nucleotide binding] 405534000551 Int/Topo IB signature motif; other site 405534000552 YueH-like protein; Region: YueH; pfam14166 405534000553 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 405534000554 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 405534000555 Neogenin C-terminus; Region: Neogenin_C; pfam06583 405534000556 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 405534000557 non-specific DNA binding site [nucleotide binding]; other site 405534000558 salt bridge; other site 405534000559 sequence-specific DNA binding site [nucleotide binding]; other site 405534000560 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 405534000561 DNA binding residues [nucleotide binding] 405534000562 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 405534000563 Mg binding site [ion binding]; other site 405534000564 nucleotide binding site [chemical binding]; other site 405534000565 putative protofilament interface [polypeptide binding]; other site 405534000566 Helix-turn-helix domain; Region: HTH_17; pfam12728 405534000567 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 405534000568 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 405534000569 active site 405534000570 catalytic residues [active] 405534000571 DNA binding site [nucleotide binding] 405534000572 Int/Topo IB signature motif; other site 405534000573 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 405534000574 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 405534000575 DnaA N-terminal domain; Region: DnaA_N; pfam11638 405534000576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534000577 Walker A motif; other site 405534000578 ATP binding site [chemical binding]; other site 405534000579 Walker B motif; other site 405534000580 arginine finger; other site 405534000581 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 405534000582 DnaA box-binding interface [nucleotide binding]; other site 405534000583 DNA polymerase III subunit beta; Validated; Region: PRK05643 405534000584 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 405534000585 putative DNA binding surface [nucleotide binding]; other site 405534000586 dimer interface [polypeptide binding]; other site 405534000587 beta-clamp/clamp loader binding surface; other site 405534000588 beta-clamp/translesion DNA polymerase binding surface; other site 405534000589 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 405534000590 recombination protein F; Reviewed; Region: recF; PRK00064 405534000591 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 405534000592 Walker A/P-loop; other site 405534000593 ATP binding site [chemical binding]; other site 405534000594 Q-loop/lid; other site 405534000595 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534000596 ABC transporter signature motif; other site 405534000597 Walker B; other site 405534000598 D-loop; other site 405534000599 H-loop/switch region; other site 405534000600 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 405534000601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534000602 Mg2+ binding site [ion binding]; other site 405534000603 G-X-G motif; other site 405534000604 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 405534000605 anchoring element; other site 405534000606 dimer interface [polypeptide binding]; other site 405534000607 ATP binding site [chemical binding]; other site 405534000608 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 405534000609 active site 405534000610 putative metal-binding site [ion binding]; other site 405534000611 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 405534000612 DNA gyrase subunit A; Validated; Region: PRK05560 405534000613 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 405534000614 CAP-like domain; other site 405534000615 active site 405534000616 primary dimer interface [polypeptide binding]; other site 405534000617 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405534000618 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405534000619 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405534000620 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405534000621 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405534000622 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405534000623 YaaC-like Protein; Region: YaaC; pfam14175 405534000624 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 405534000625 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 405534000626 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 405534000627 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 405534000628 active site 405534000629 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 405534000630 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405534000631 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 405534000632 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 405534000633 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 405534000634 active site 405534000635 multimer interface [polypeptide binding]; other site 405534000636 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 405534000637 predicted active site [active] 405534000638 catalytic triad [active] 405534000639 seryl-tRNA synthetase; Provisional; Region: PRK05431 405534000640 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 405534000641 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 405534000642 dimer interface [polypeptide binding]; other site 405534000643 active site 405534000644 motif 1; other site 405534000645 motif 2; other site 405534000646 motif 3; other site 405534000647 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 405534000648 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 405534000649 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 405534000650 DNA binding residues [nucleotide binding] 405534000651 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 405534000652 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 405534000653 Substrate-binding site [chemical binding]; other site 405534000654 Substrate specificity [chemical binding]; other site 405534000655 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 405534000656 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 405534000657 Substrate-binding site [chemical binding]; other site 405534000658 Substrate specificity [chemical binding]; other site 405534000659 Isochorismatase family; Region: Isochorismatase; pfam00857 405534000660 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 405534000661 catalytic triad [active] 405534000662 conserved cis-peptide bond; other site 405534000663 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 405534000664 nucleoside/Zn binding site; other site 405534000665 dimer interface [polypeptide binding]; other site 405534000666 catalytic motif [active] 405534000667 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 405534000668 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534000669 Walker A motif; other site 405534000670 ATP binding site [chemical binding]; other site 405534000671 Walker B motif; other site 405534000672 arginine finger; other site 405534000673 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 405534000674 hypothetical protein; Validated; Region: PRK00153 405534000675 recombination protein RecR; Reviewed; Region: recR; PRK00076 405534000676 RecR protein; Region: RecR; pfam02132 405534000677 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 405534000678 putative active site [active] 405534000679 putative metal-binding site [ion binding]; other site 405534000680 tetramer interface [polypeptide binding]; other site 405534000681 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 405534000682 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 405534000683 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 405534000684 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 405534000685 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 405534000686 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405534000687 catalytic residue [active] 405534000688 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 405534000689 thymidylate kinase; Validated; Region: tmk; PRK00698 405534000690 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 405534000691 TMP-binding site; other site 405534000692 ATP-binding site [chemical binding]; other site 405534000693 DNA polymerase III subunit delta'; Validated; Region: PRK08058 405534000694 DNA polymerase III subunit delta'; Validated; Region: PRK08485 405534000695 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 405534000696 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 405534000697 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 405534000698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534000699 S-adenosylmethionine binding site [chemical binding]; other site 405534000700 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 405534000701 putative active site [active] 405534000702 GIY-YIG motif/motif A; other site 405534000703 putative metal binding site [ion binding]; other site 405534000704 Predicted methyltransferases [General function prediction only]; Region: COG0313 405534000705 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 405534000706 putative SAM binding site [chemical binding]; other site 405534000707 putative homodimer interface [polypeptide binding]; other site 405534000708 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 405534000709 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 405534000710 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 405534000711 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 405534000712 active site 405534000713 HIGH motif; other site 405534000714 KMSKS motif; other site 405534000715 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 405534000716 tRNA binding surface [nucleotide binding]; other site 405534000717 anticodon binding site; other site 405534000718 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 405534000719 dimer interface [polypeptide binding]; other site 405534000720 putative tRNA-binding site [nucleotide binding]; other site 405534000721 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 405534000722 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 405534000723 active site 405534000724 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 405534000725 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 405534000726 putative active site [active] 405534000727 putative metal binding site [ion binding]; other site 405534000728 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 405534000729 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 405534000730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534000731 S-adenosylmethionine binding site [chemical binding]; other site 405534000732 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 405534000733 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 405534000734 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405534000735 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 405534000736 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 405534000737 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 405534000738 pur operon repressor; Provisional; Region: PRK09213 405534000739 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 405534000740 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405534000741 active site 405534000742 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 405534000743 homotrimer interaction site [polypeptide binding]; other site 405534000744 putative active site [active] 405534000745 regulatory protein SpoVG; Reviewed; Region: PRK13259 405534000746 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 405534000747 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 405534000748 Substrate binding site; other site 405534000749 Mg++ binding site; other site 405534000750 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 405534000751 active site 405534000752 substrate binding site [chemical binding]; other site 405534000753 CoA binding site [chemical binding]; other site 405534000754 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 405534000755 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 405534000756 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405534000757 active site 405534000758 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 405534000759 putative active site [active] 405534000760 catalytic residue [active] 405534000761 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 405534000762 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 405534000763 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 405534000764 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405534000765 ATP binding site [chemical binding]; other site 405534000766 putative Mg++ binding site [ion binding]; other site 405534000767 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405534000768 nucleotide binding region [chemical binding]; other site 405534000769 ATP-binding site [chemical binding]; other site 405534000770 TRCF domain; Region: TRCF; pfam03461 405534000771 stage V sporulation protein T; Region: spore_V_T; TIGR02851 405534000772 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 405534000773 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405534000774 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 405534000775 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 405534000776 putative SAM binding site [chemical binding]; other site 405534000777 putative homodimer interface [polypeptide binding]; other site 405534000778 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 405534000779 homodimer interface [polypeptide binding]; other site 405534000780 metal binding site [ion binding]; metal-binding site 405534000781 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 405534000782 homodimer interface [polypeptide binding]; other site 405534000783 active site 405534000784 putative chemical substrate binding site [chemical binding]; other site 405534000785 metal binding site [ion binding]; metal-binding site 405534000786 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405534000787 RNA binding surface [nucleotide binding]; other site 405534000788 sporulation protein YabP; Region: spore_yabP; TIGR02892 405534000789 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 405534000790 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 405534000791 Septum formation initiator; Region: DivIC; pfam04977 405534000792 hypothetical protein; Provisional; Region: PRK08582 405534000793 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 405534000794 RNA binding site [nucleotide binding]; other site 405534000795 stage II sporulation protein E; Region: spore_II_E; TIGR02865 405534000796 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 405534000797 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 405534000798 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 405534000799 Ligand Binding Site [chemical binding]; other site 405534000800 TilS substrate binding domain; Region: TilS; pfam09179 405534000801 TilS substrate C-terminal domain; Region: TilS_C; smart00977 405534000802 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405534000803 active site 405534000804 FtsH Extracellular; Region: FtsH_ext; pfam06480 405534000805 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 405534000806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534000807 Walker A motif; other site 405534000808 ATP binding site [chemical binding]; other site 405534000809 Walker B motif; other site 405534000810 arginine finger; other site 405534000811 Peptidase family M41; Region: Peptidase_M41; pfam01434 405534000812 pantothenate kinase; Reviewed; Region: PRK13318 405534000813 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 405534000814 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 405534000815 dimerization interface [polypeptide binding]; other site 405534000816 domain crossover interface; other site 405534000817 redox-dependent activation switch; other site 405534000818 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 405534000819 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 405534000820 dimer interface [polypeptide binding]; other site 405534000821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534000822 catalytic residue [active] 405534000823 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 405534000824 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 405534000825 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 405534000826 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 405534000827 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 405534000828 glutamine binding [chemical binding]; other site 405534000829 catalytic triad [active] 405534000830 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 405534000831 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 405534000832 homodimer interface [polypeptide binding]; other site 405534000833 substrate-cofactor binding pocket; other site 405534000834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534000835 catalytic residue [active] 405534000836 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 405534000837 dihydropteroate synthase; Region: DHPS; TIGR01496 405534000838 substrate binding pocket [chemical binding]; other site 405534000839 dimer interface [polypeptide binding]; other site 405534000840 inhibitor binding site; inhibition site 405534000841 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 405534000842 homooctamer interface [polypeptide binding]; other site 405534000843 active site 405534000844 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 405534000845 catalytic center binding site [active] 405534000846 ATP binding site [chemical binding]; other site 405534000847 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405534000848 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534000849 non-specific DNA binding site [nucleotide binding]; other site 405534000850 salt bridge; other site 405534000851 sequence-specific DNA binding site [nucleotide binding]; other site 405534000852 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 405534000853 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 405534000854 FMN binding site [chemical binding]; other site 405534000855 active site 405534000856 catalytic residues [active] 405534000857 substrate binding site [chemical binding]; other site 405534000858 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 405534000859 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 405534000860 dimer interface [polypeptide binding]; other site 405534000861 putative anticodon binding site; other site 405534000862 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 405534000863 motif 1; other site 405534000864 active site 405534000865 motif 2; other site 405534000866 motif 3; other site 405534000867 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 405534000868 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 405534000869 UvrB/uvrC motif; Region: UVR; pfam02151 405534000870 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 405534000871 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 405534000872 ADP binding site [chemical binding]; other site 405534000873 phosphagen binding site; other site 405534000874 substrate specificity loop; other site 405534000875 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 405534000876 Clp amino terminal domain; Region: Clp_N; pfam02861 405534000877 Clp amino terminal domain; Region: Clp_N; pfam02861 405534000878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534000879 Walker A motif; other site 405534000880 ATP binding site [chemical binding]; other site 405534000881 Walker B motif; other site 405534000882 arginine finger; other site 405534000883 UvrB/uvrC motif; Region: UVR; pfam02151 405534000884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534000885 Walker A motif; other site 405534000886 ATP binding site [chemical binding]; other site 405534000887 Walker B motif; other site 405534000888 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 405534000889 DNA repair protein RadA; Provisional; Region: PRK11823 405534000890 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 405534000891 Walker A motif/ATP binding site; other site 405534000892 ATP binding site [chemical binding]; other site 405534000893 Walker B motif; other site 405534000894 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 405534000895 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 405534000896 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 405534000897 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 405534000898 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 405534000899 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 405534000900 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 405534000901 putative active site [active] 405534000902 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 405534000903 substrate binding site; other site 405534000904 dimer interface; other site 405534000905 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 405534000906 homotrimer interaction site [polypeptide binding]; other site 405534000907 zinc binding site [ion binding]; other site 405534000908 CDP-binding sites; other site 405534000909 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 405534000910 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 405534000911 active site 405534000912 HIGH motif; other site 405534000913 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 405534000914 active site 405534000915 KMSKS motif; other site 405534000916 serine O-acetyltransferase; Region: cysE; TIGR01172 405534000917 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 405534000918 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 405534000919 trimer interface [polypeptide binding]; other site 405534000920 active site 405534000921 substrate binding site [chemical binding]; other site 405534000922 CoA binding site [chemical binding]; other site 405534000923 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 405534000924 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 405534000925 active site 405534000926 HIGH motif; other site 405534000927 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 405534000928 KMSKS motif; other site 405534000929 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 405534000930 tRNA binding surface [nucleotide binding]; other site 405534000931 anticodon binding site; other site 405534000932 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 405534000933 active site 405534000934 metal binding site [ion binding]; metal-binding site 405534000935 dimerization interface [polypeptide binding]; other site 405534000936 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 405534000937 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 405534000938 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 405534000939 YacP-like NYN domain; Region: NYN_YacP; pfam05991 405534000940 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 405534000941 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405534000942 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 405534000943 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 405534000944 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 405534000945 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 405534000946 putative homodimer interface [polypeptide binding]; other site 405534000947 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 405534000948 heterodimer interface [polypeptide binding]; other site 405534000949 homodimer interface [polypeptide binding]; other site 405534000950 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 405534000951 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 405534000952 23S rRNA interface [nucleotide binding]; other site 405534000953 L7/L12 interface [polypeptide binding]; other site 405534000954 putative thiostrepton binding site; other site 405534000955 L25 interface [polypeptide binding]; other site 405534000956 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 405534000957 mRNA/rRNA interface [nucleotide binding]; other site 405534000958 Ribosomal protein L10 leader 405534000959 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 405534000960 23S rRNA interface [nucleotide binding]; other site 405534000961 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 405534000962 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 405534000963 core dimer interface [polypeptide binding]; other site 405534000964 peripheral dimer interface [polypeptide binding]; other site 405534000965 L10 interface [polypeptide binding]; other site 405534000966 L11 interface [polypeptide binding]; other site 405534000967 putative EF-Tu interaction site [polypeptide binding]; other site 405534000968 putative EF-G interaction site [polypeptide binding]; other site 405534000969 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 405534000970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534000971 S-adenosylmethionine binding site [chemical binding]; other site 405534000972 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 405534000973 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 405534000974 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 405534000975 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 405534000976 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 405534000977 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 405534000978 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 405534000979 RPB10 interaction site [polypeptide binding]; other site 405534000980 RPB1 interaction site [polypeptide binding]; other site 405534000981 RPB11 interaction site [polypeptide binding]; other site 405534000982 RPB3 interaction site [polypeptide binding]; other site 405534000983 RPB12 interaction site [polypeptide binding]; other site 405534000984 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 405534000985 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 405534000986 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 405534000987 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 405534000988 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 405534000989 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 405534000990 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 405534000991 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 405534000992 G-loop; other site 405534000993 DNA binding site [nucleotide binding] 405534000994 hypothetical protein; Provisional; Region: PRK06683 405534000995 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 405534000996 S17 interaction site [polypeptide binding]; other site 405534000997 S8 interaction site; other site 405534000998 16S rRNA interaction site [nucleotide binding]; other site 405534000999 streptomycin interaction site [chemical binding]; other site 405534001000 23S rRNA interaction site [nucleotide binding]; other site 405534001001 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 405534001002 30S ribosomal protein S7; Validated; Region: PRK05302 405534001003 elongation factor G; Reviewed; Region: PRK00007 405534001004 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 405534001005 G1 box; other site 405534001006 putative GEF interaction site [polypeptide binding]; other site 405534001007 GTP/Mg2+ binding site [chemical binding]; other site 405534001008 Switch I region; other site 405534001009 G2 box; other site 405534001010 G3 box; other site 405534001011 Switch II region; other site 405534001012 G4 box; other site 405534001013 G5 box; other site 405534001014 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 405534001015 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 405534001016 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 405534001017 elongation factor Tu; Reviewed; Region: PRK00049 405534001018 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 405534001019 G1 box; other site 405534001020 GEF interaction site [polypeptide binding]; other site 405534001021 GTP/Mg2+ binding site [chemical binding]; other site 405534001022 Switch I region; other site 405534001023 G2 box; other site 405534001024 G3 box; other site 405534001025 Switch II region; other site 405534001026 G4 box; other site 405534001027 G5 box; other site 405534001028 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 405534001029 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 405534001030 Antibiotic Binding Site [chemical binding]; other site 405534001031 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 405534001032 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 405534001033 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 405534001034 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 405534001035 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 405534001036 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 405534001037 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 405534001038 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 405534001039 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 405534001040 putative translocon binding site; other site 405534001041 protein-rRNA interface [nucleotide binding]; other site 405534001042 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 405534001043 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 405534001044 G-X-X-G motif; other site 405534001045 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 405534001046 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 405534001047 23S rRNA interface [nucleotide binding]; other site 405534001048 5S rRNA interface [nucleotide binding]; other site 405534001049 putative antibiotic binding site [chemical binding]; other site 405534001050 L25 interface [polypeptide binding]; other site 405534001051 L27 interface [polypeptide binding]; other site 405534001052 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 405534001053 23S rRNA interface [nucleotide binding]; other site 405534001054 putative translocon interaction site; other site 405534001055 signal recognition particle (SRP54) interaction site; other site 405534001056 L23 interface [polypeptide binding]; other site 405534001057 trigger factor interaction site; other site 405534001058 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 405534001059 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 405534001060 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 405534001061 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 405534001062 RNA binding site [nucleotide binding]; other site 405534001063 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 405534001064 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 405534001065 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 405534001066 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 405534001067 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 405534001068 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 405534001069 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 405534001070 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 405534001071 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 405534001072 5S rRNA interface [nucleotide binding]; other site 405534001073 L27 interface [polypeptide binding]; other site 405534001074 23S rRNA interface [nucleotide binding]; other site 405534001075 L5 interface [polypeptide binding]; other site 405534001076 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 405534001077 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 405534001078 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 405534001079 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 405534001080 23S rRNA binding site [nucleotide binding]; other site 405534001081 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 405534001082 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 405534001083 SecY translocase; Region: SecY; pfam00344 405534001084 adenylate kinase; Reviewed; Region: adk; PRK00279 405534001085 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 405534001086 AMP-binding site [chemical binding]; other site 405534001087 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 405534001088 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 405534001089 active site 405534001090 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 405534001091 rRNA binding site [nucleotide binding]; other site 405534001092 predicted 30S ribosome binding site; other site 405534001093 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 405534001094 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 405534001095 30S ribosomal protein S13; Region: bact_S13; TIGR03631 405534001096 30S ribosomal protein S11; Validated; Region: PRK05309 405534001097 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 405534001098 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 405534001099 alphaNTD - beta interaction site [polypeptide binding]; other site 405534001100 alphaNTD homodimer interface [polypeptide binding]; other site 405534001101 alphaNTD - beta' interaction site [polypeptide binding]; other site 405534001102 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 405534001103 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 405534001104 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 405534001105 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405534001106 Walker A/P-loop; other site 405534001107 ATP binding site [chemical binding]; other site 405534001108 Q-loop/lid; other site 405534001109 ABC transporter signature motif; other site 405534001110 Walker B; other site 405534001111 D-loop; other site 405534001112 H-loop/switch region; other site 405534001113 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 405534001114 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405534001115 Walker A/P-loop; other site 405534001116 ATP binding site [chemical binding]; other site 405534001117 Q-loop/lid; other site 405534001118 ABC transporter signature motif; other site 405534001119 Walker B; other site 405534001120 D-loop; other site 405534001121 H-loop/switch region; other site 405534001122 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 405534001123 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 405534001124 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 405534001125 dimerization interface 3.5A [polypeptide binding]; other site 405534001126 active site 405534001127 Ribosomal protein L13 leader 405534001128 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 405534001129 23S rRNA interface [nucleotide binding]; other site 405534001130 L3 interface [polypeptide binding]; other site 405534001131 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 405534001132 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 405534001133 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 405534001134 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405534001135 active site 405534001136 metal binding site [ion binding]; metal-binding site 405534001137 Domain of unknown function DUF59; Region: DUF59; pfam01883 405534001138 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 405534001139 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 405534001140 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 405534001141 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405534001142 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 405534001143 NodB motif; other site 405534001144 putative active site [active] 405534001145 putative catalytic site [active] 405534001146 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 405534001147 Arginase family; Region: Arginase; cd09989 405534001148 agmatinase; Region: agmatinase; TIGR01230 405534001149 active site 405534001150 Mn binding site [ion binding]; other site 405534001151 oligomer interface [polypeptide binding]; other site 405534001152 Uncharacterized conserved protein [Function unknown]; Region: COG1624 405534001153 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 405534001154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 405534001155 YbbR-like protein; Region: YbbR; pfam07949 405534001156 YbbR-like protein; Region: YbbR; pfam07949 405534001157 YbbR-like protein; Region: YbbR; pfam07949 405534001158 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 405534001159 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 405534001160 active site 405534001161 substrate binding site [chemical binding]; other site 405534001162 metal binding site [ion binding]; metal-binding site 405534001163 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 405534001164 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 405534001165 glutaminase active site [active] 405534001166 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 405534001167 dimer interface [polypeptide binding]; other site 405534001168 active site 405534001169 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 405534001170 dimer interface [polypeptide binding]; other site 405534001171 active site 405534001172 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405534001173 Transcriptional regulators [Transcription]; Region: GntR; COG1802 405534001174 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405534001175 DNA-binding site [nucleotide binding]; DNA binding site 405534001176 FCD domain; Region: FCD; pfam07729 405534001177 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 405534001178 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 405534001179 N- and C-terminal domain interface [polypeptide binding]; other site 405534001180 active site 405534001181 catalytic site [active] 405534001182 metal binding site [ion binding]; metal-binding site 405534001183 carbohydrate binding site [chemical binding]; other site 405534001184 ATP binding site [chemical binding]; other site 405534001185 fructuronate transporter; Provisional; Region: PRK10034; cl15264 405534001186 gluconate transporter; Region: gntP; TIGR00791 405534001187 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405534001188 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 405534001189 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 405534001190 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 405534001191 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405534001192 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 405534001193 DoxX; Region: DoxX; cl17842 405534001194 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 405534001195 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 405534001196 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 405534001197 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405534001198 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405534001199 DNA binding residues [nucleotide binding] 405534001200 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 405534001201 classical (c) SDRs; Region: SDR_c; cd05233 405534001202 NAD(P) binding site [chemical binding]; other site 405534001203 active site 405534001204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534001205 ABC-ATPase subunit interface; other site 405534001206 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 405534001207 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 405534001208 Walker A/P-loop; other site 405534001209 ATP binding site [chemical binding]; other site 405534001210 Q-loop/lid; other site 405534001211 ABC transporter signature motif; other site 405534001212 Walker B; other site 405534001213 D-loop; other site 405534001214 H-loop/switch region; other site 405534001215 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405534001216 NIL domain; Region: NIL; pfam09383 405534001217 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 405534001218 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 405534001219 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405534001220 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 405534001221 putative NAD(P) binding site [chemical binding]; other site 405534001222 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 405534001223 FAD binding domain; Region: FAD_binding_4; pfam01565 405534001224 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 405534001225 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534001226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534001227 putative substrate translocation pore; other site 405534001228 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 405534001229 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 405534001230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534001231 putative substrate translocation pore; other site 405534001232 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 405534001233 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405534001234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534001235 dimer interface [polypeptide binding]; other site 405534001236 conserved gate region; other site 405534001237 putative PBP binding loops; other site 405534001238 ABC-ATPase subunit interface; other site 405534001239 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405534001240 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 405534001241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534001242 dimer interface [polypeptide binding]; other site 405534001243 conserved gate region; other site 405534001244 putative PBP binding loops; other site 405534001245 ABC-ATPase subunit interface; other site 405534001246 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 405534001247 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405534001248 Walker A/P-loop; other site 405534001249 ATP binding site [chemical binding]; other site 405534001250 Q-loop/lid; other site 405534001251 ABC transporter signature motif; other site 405534001252 Walker B; other site 405534001253 D-loop; other site 405534001254 H-loop/switch region; other site 405534001255 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405534001256 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 405534001257 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405534001258 Walker A/P-loop; other site 405534001259 ATP binding site [chemical binding]; other site 405534001260 Q-loop/lid; other site 405534001261 ABC transporter signature motif; other site 405534001262 Walker B; other site 405534001263 D-loop; other site 405534001264 H-loop/switch region; other site 405534001265 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 405534001266 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405534001267 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405534001268 peptide binding site [polypeptide binding]; other site 405534001269 YusW-like protein; Region: YusW; pfam14039 405534001270 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405534001271 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405534001272 peptide binding site [polypeptide binding]; other site 405534001273 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405534001274 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405534001275 peptide binding site [polypeptide binding]; other site 405534001276 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405534001277 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405534001278 active site 405534001279 catalytic tetrad [active] 405534001280 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 405534001281 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 405534001282 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 405534001283 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 405534001284 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 405534001285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534001286 putative PBP binding loops; other site 405534001287 dimer interface [polypeptide binding]; other site 405534001288 ABC-ATPase subunit interface; other site 405534001289 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 405534001290 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 405534001291 dimerization interface [polypeptide binding]; other site 405534001292 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405534001293 membrane-bound complex binding site; other site 405534001294 hinge residues; other site 405534001295 DNA binding domain, excisionase family; Region: excise; TIGR01764 405534001296 PBP superfamily domain; Region: PBP_like; pfam12727 405534001297 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405534001298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405534001299 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 405534001300 putative dimerization interface [polypeptide binding]; other site 405534001301 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405534001302 EamA-like transporter family; Region: EamA; pfam00892 405534001303 YrzO-like protein; Region: YrzO; pfam14142 405534001304 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 405534001305 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 405534001306 putative acyl-acceptor binding pocket; other site 405534001307 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405534001308 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405534001309 DNA binding site [nucleotide binding] 405534001310 domain linker motif; other site 405534001311 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 405534001312 putative ligand binding site [chemical binding]; other site 405534001313 putative dimerization interface [polypeptide binding]; other site 405534001314 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405534001315 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405534001316 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405534001317 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405534001318 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405534001319 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 405534001320 active site 405534001321 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 405534001322 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 405534001323 C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441 405534001324 lysozyme catalytic site [active] 405534001325 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 405534001326 nucleotide binding site/active site [active] 405534001327 HIT family signature motif; other site 405534001328 catalytic residue [active] 405534001329 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405534001330 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405534001331 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405534001332 ABC transporter; Region: ABC_tran_2; pfam12848 405534001333 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405534001334 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 405534001335 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 405534001336 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 405534001337 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 405534001338 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405534001339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534001340 dimer interface [polypeptide binding]; other site 405534001341 conserved gate region; other site 405534001342 putative PBP binding loops; other site 405534001343 ABC-ATPase subunit interface; other site 405534001344 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405534001345 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 405534001346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534001347 dimer interface [polypeptide binding]; other site 405534001348 conserved gate region; other site 405534001349 putative PBP binding loops; other site 405534001350 ABC-ATPase subunit interface; other site 405534001351 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 405534001352 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405534001353 Walker A/P-loop; other site 405534001354 ATP binding site [chemical binding]; other site 405534001355 Q-loop/lid; other site 405534001356 ABC transporter signature motif; other site 405534001357 Walker B; other site 405534001358 D-loop; other site 405534001359 H-loop/switch region; other site 405534001360 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 405534001361 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 405534001362 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405534001363 Walker A/P-loop; other site 405534001364 ATP binding site [chemical binding]; other site 405534001365 Q-loop/lid; other site 405534001366 ABC transporter signature motif; other site 405534001367 Walker B; other site 405534001368 D-loop; other site 405534001369 H-loop/switch region; other site 405534001370 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 405534001371 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534001372 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405534001373 active site 405534001374 motif I; other site 405534001375 motif II; other site 405534001376 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534001377 motif II; other site 405534001378 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 405534001379 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 405534001380 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 405534001381 dimer interface [polypeptide binding]; other site 405534001382 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 405534001383 active site 405534001384 Fe binding site [ion binding]; other site 405534001385 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 405534001386 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 405534001387 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 405534001388 amino acid transporter; Region: 2A0306; TIGR00909 405534001389 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 405534001390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534001391 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534001392 putative substrate translocation pore; other site 405534001393 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 405534001394 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 405534001395 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 405534001396 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 405534001397 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 405534001398 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405534001399 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405534001400 helicase 45; Provisional; Region: PTZ00424 405534001401 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 405534001402 ATP binding site [chemical binding]; other site 405534001403 Mg++ binding site [ion binding]; other site 405534001404 motif III; other site 405534001405 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405534001406 nucleotide binding region [chemical binding]; other site 405534001407 ATP-binding site [chemical binding]; other site 405534001408 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 405534001409 Rhomboid family; Region: Rhomboid; pfam01694 405534001410 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 405534001411 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 405534001412 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 405534001413 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 405534001414 alanine racemase; Reviewed; Region: alr; PRK00053 405534001415 active site 405534001416 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405534001417 dimer interface [polypeptide binding]; other site 405534001418 substrate binding site [chemical binding]; other site 405534001419 catalytic residues [active] 405534001420 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 405534001421 PemK-like protein; Region: PemK; pfam02452 405534001422 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 405534001423 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 405534001424 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 405534001425 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 405534001426 RNA binding site [nucleotide binding]; other site 405534001427 SprT homologues; Region: SprT; cl01182 405534001428 SprT-like family; Region: SprT-like; pfam10263 405534001429 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 405534001430 Glycoprotease family; Region: Peptidase_M22; pfam00814 405534001431 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 405534001432 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 405534001433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534001434 Coenzyme A binding pocket [chemical binding]; other site 405534001435 UGMP family protein; Validated; Region: PRK09604 405534001436 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 405534001437 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 405534001438 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405534001439 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405534001440 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405534001441 ABC transporter; Region: ABC_tran_2; pfam12848 405534001442 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405534001443 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 405534001444 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 405534001445 CoA binding domain; Region: CoA_binding; pfam02629 405534001446 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 405534001447 CAAX protease self-immunity; Region: Abi; pfam02517 405534001448 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 405534001449 oligomerisation interface [polypeptide binding]; other site 405534001450 mobile loop; other site 405534001451 roof hairpin; other site 405534001452 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 405534001453 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 405534001454 ring oligomerisation interface [polypeptide binding]; other site 405534001455 ATP/Mg binding site [chemical binding]; other site 405534001456 stacking interactions; other site 405534001457 hinge regions; other site 405534001458 GMP synthase; Reviewed; Region: guaA; PRK00074 405534001459 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 405534001460 AMP/PPi binding site [chemical binding]; other site 405534001461 candidate oxyanion hole; other site 405534001462 catalytic triad [active] 405534001463 potential glutamine specificity residues [chemical binding]; other site 405534001464 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 405534001465 ATP Binding subdomain [chemical binding]; other site 405534001466 Ligand Binding sites [chemical binding]; other site 405534001467 Dimerization subdomain; other site 405534001468 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405534001469 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534001470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534001471 active site 405534001472 phosphorylation site [posttranslational modification] 405534001473 intermolecular recognition site; other site 405534001474 dimerization interface [polypeptide binding]; other site 405534001475 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534001476 DNA binding site [nucleotide binding] 405534001477 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534001478 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534001479 dimerization interface [polypeptide binding]; other site 405534001480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534001481 dimer interface [polypeptide binding]; other site 405534001482 phosphorylation site [posttranslational modification] 405534001483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534001484 ATP binding site [chemical binding]; other site 405534001485 Mg2+ binding site [ion binding]; other site 405534001486 G-X-G motif; other site 405534001487 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 405534001488 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 405534001489 catalytic residues [active] 405534001490 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 405534001491 putative ligand binding site [chemical binding]; other site 405534001492 putative catalytic site [active] 405534001493 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405534001494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534001495 S-adenosylmethionine binding site [chemical binding]; other site 405534001496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534001497 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 405534001498 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405534001499 UDP-glucose 4-epimerase (G4E), subgroup 5, extended (e) SDRs; Region: UDP_G4E_5_SDR_e; cd05264 405534001500 putative NAD(P) binding site [chemical binding]; other site 405534001501 active site 405534001502 putative substrate binding site [chemical binding]; other site 405534001503 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405534001504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534001505 S-adenosylmethionine binding site [chemical binding]; other site 405534001506 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405534001507 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 405534001508 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405534001509 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405534001510 active site 405534001511 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405534001512 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405534001513 DNA-binding site [nucleotide binding]; DNA binding site 405534001514 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405534001515 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534001516 homodimer interface [polypeptide binding]; other site 405534001517 catalytic residue [active] 405534001518 Proline dehydrogenase; Region: Pro_dh; cl03282 405534001519 Probable transposase; Region: OrfB_IS605; pfam01385 405534001520 EamA-like transporter family; Region: EamA; pfam00892 405534001521 Homeodomain-like domain; Region: HTH_23; pfam13384 405534001522 putative transposase OrfB; Reviewed; Region: PHA02517 405534001523 HTH-like domain; Region: HTH_21; pfam13276 405534001524 Integrase core domain; Region: rve; pfam00665 405534001525 Integrase core domain; Region: rve_2; pfam13333 405534001526 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 405534001527 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 405534001528 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 405534001529 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 405534001530 NAD binding site [chemical binding]; other site 405534001531 ATP-grasp domain; Region: ATP-grasp; pfam02222 405534001532 adenylosuccinate lyase; Provisional; Region: PRK07492 405534001533 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 405534001534 tetramer interface [polypeptide binding]; other site 405534001535 active site 405534001536 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 405534001537 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 405534001538 ATP binding site [chemical binding]; other site 405534001539 active site 405534001540 substrate binding site [chemical binding]; other site 405534001541 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 405534001542 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 405534001543 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 405534001544 putative active site [active] 405534001545 catalytic triad [active] 405534001546 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 405534001547 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 405534001548 dimerization interface [polypeptide binding]; other site 405534001549 ATP binding site [chemical binding]; other site 405534001550 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 405534001551 dimerization interface [polypeptide binding]; other site 405534001552 ATP binding site [chemical binding]; other site 405534001553 amidophosphoribosyltransferase; Provisional; Region: PRK06781 405534001554 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 405534001555 active site 405534001556 tetramer interface [polypeptide binding]; other site 405534001557 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405534001558 active site 405534001559 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 405534001560 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 405534001561 dimerization interface [polypeptide binding]; other site 405534001562 putative ATP binding site [chemical binding]; other site 405534001563 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 405534001564 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 405534001565 active site 405534001566 substrate binding site [chemical binding]; other site 405534001567 cosubstrate binding site; other site 405534001568 catalytic site [active] 405534001569 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 405534001570 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 405534001571 purine monophosphate binding site [chemical binding]; other site 405534001572 dimer interface [polypeptide binding]; other site 405534001573 putative catalytic residues [active] 405534001574 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 405534001575 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 405534001576 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 405534001577 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 405534001578 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 405534001579 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 405534001580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 405534001581 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 405534001582 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 405534001583 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 405534001584 PcrB family; Region: PcrB; pfam01884 405534001585 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 405534001586 substrate binding site [chemical binding]; other site 405534001587 putative active site [active] 405534001588 dimer interface [polypeptide binding]; other site 405534001589 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 405534001590 Part of AAA domain; Region: AAA_19; pfam13245 405534001591 Family description; Region: UvrD_C_2; pfam13538 405534001592 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 405534001593 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 405534001594 nucleotide binding pocket [chemical binding]; other site 405534001595 K-X-D-G motif; other site 405534001596 catalytic site [active] 405534001597 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 405534001598 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 405534001599 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 405534001600 Dimer interface [polypeptide binding]; other site 405534001601 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 405534001602 putative dimer interface [polypeptide binding]; other site 405534001603 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 405534001604 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 405534001605 putative dimer interface [polypeptide binding]; other site 405534001606 hypothetical protein; Provisional; Region: PRK10621 405534001607 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405534001608 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 405534001609 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 405534001610 Glutamate binding site [chemical binding]; other site 405534001611 homodimer interface [polypeptide binding]; other site 405534001612 NAD binding site [chemical binding]; other site 405534001613 catalytic residues [active] 405534001614 Isochorismatase family; Region: Isochorismatase; pfam00857 405534001615 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 405534001616 catalytic triad [active] 405534001617 conserved cis-peptide bond; other site 405534001618 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 405534001619 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 405534001620 Walker A/P-loop; other site 405534001621 ATP binding site [chemical binding]; other site 405534001622 Q-loop/lid; other site 405534001623 ABC transporter signature motif; other site 405534001624 Walker B; other site 405534001625 D-loop; other site 405534001626 H-loop/switch region; other site 405534001627 NIL domain; Region: NIL; pfam09383 405534001628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534001629 dimer interface [polypeptide binding]; other site 405534001630 conserved gate region; other site 405534001631 ABC-ATPase subunit interface; other site 405534001632 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 405534001633 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 405534001634 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 405534001635 Protein of unknown function (DUF3926); Region: DUF3926; pfam13080 405534001636 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 405534001637 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 405534001638 P loop; other site 405534001639 Nucleotide binding site [chemical binding]; other site 405534001640 DTAP/Switch II; other site 405534001641 Switch I; other site 405534001642 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 405534001643 putative dimer interface [polypeptide binding]; other site 405534001644 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405534001645 MarR family; Region: MarR; pfam01047 405534001646 MarR family; Region: MarR_2; cl17246 405534001647 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 405534001648 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 405534001649 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 405534001650 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 405534001651 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 405534001652 GatB domain; Region: GatB_Yqey; pfam02637 405534001653 putative lipid kinase; Reviewed; Region: PRK13337 405534001654 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 405534001655 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 405534001656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 405534001657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534001658 S-adenosylmethionine binding site [chemical binding]; other site 405534001659 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 405534001660 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534001661 motif II; other site 405534001662 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 405534001663 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405534001664 inhibitor-cofactor binding pocket; inhibition site 405534001665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534001666 catalytic residue [active] 405534001667 PAS domain; Region: PAS_9; pfam13426 405534001668 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405534001669 putative active site [active] 405534001670 heme pocket [chemical binding]; other site 405534001671 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 405534001672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534001673 Walker A motif; other site 405534001674 ATP binding site [chemical binding]; other site 405534001675 Walker B motif; other site 405534001676 arginine finger; other site 405534001677 succinic semialdehyde dehydrogenase; Region: PLN02278 405534001678 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 405534001679 tetramerization interface [polypeptide binding]; other site 405534001680 NAD(P) binding site [chemical binding]; other site 405534001681 catalytic residues [active] 405534001682 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405534001683 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 405534001684 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 405534001685 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405534001686 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 405534001687 putative active site [active] 405534001688 putative metal binding site [ion binding]; other site 405534001689 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405534001690 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405534001691 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405534001692 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 405534001693 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 405534001694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534001695 S-adenosylmethionine binding site [chemical binding]; other site 405534001696 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 405534001697 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 405534001698 FMN binding site [chemical binding]; other site 405534001699 active site 405534001700 catalytic residues [active] 405534001701 substrate binding site [chemical binding]; other site 405534001702 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 405534001703 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 405534001704 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 405534001705 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 405534001706 PAS domain S-box; Region: sensory_box; TIGR00229 405534001707 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405534001708 putative active site [active] 405534001709 heme pocket [chemical binding]; other site 405534001710 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405534001711 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405534001712 metal binding site [ion binding]; metal-binding site 405534001713 active site 405534001714 I-site; other site 405534001715 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405534001716 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 405534001717 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 405534001718 PYR/PP interface [polypeptide binding]; other site 405534001719 dimer interface [polypeptide binding]; other site 405534001720 TPP binding site [chemical binding]; other site 405534001721 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405534001722 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 405534001723 TPP-binding site [chemical binding]; other site 405534001724 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 405534001725 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 405534001726 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 405534001727 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405534001728 FeS/SAM binding site; other site 405534001729 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 405534001730 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405534001731 FAD binding domain; Region: FAD_binding_4; pfam01565 405534001732 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 405534001733 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 405534001734 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 405534001735 metal binding site [ion binding]; metal-binding site 405534001736 dimer interface [polypeptide binding]; other site 405534001737 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 405534001738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 405534001739 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534001740 non-specific DNA binding site [nucleotide binding]; other site 405534001741 salt bridge; other site 405534001742 sequence-specific DNA binding site [nucleotide binding]; other site 405534001743 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 405534001744 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405534001745 TPR motif; other site 405534001746 binding surface 405534001747 TPR repeat; Region: TPR_11; pfam13414 405534001748 seryl-tRNA synthetase; Provisional; Region: PRK05431 405534001749 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 405534001750 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 405534001751 dimer interface [polypeptide binding]; other site 405534001752 active site 405534001753 motif 1; other site 405534001754 motif 2; other site 405534001755 motif 3; other site 405534001756 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 405534001757 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 405534001758 catalytic triad [active] 405534001759 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405534001760 AMP-binding enzyme; Region: AMP-binding; pfam00501 405534001761 acyl-activating enzyme (AAE) consensus motif; other site 405534001762 AMP binding site [chemical binding]; other site 405534001763 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405534001764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534001765 H+ Antiporter protein; Region: 2A0121; TIGR00900 405534001766 putative substrate translocation pore; other site 405534001767 putative transposase OrfB; Reviewed; Region: PHA02517 405534001768 HTH-like domain; Region: HTH_21; pfam13276 405534001769 Integrase core domain; Region: rve; pfam00665 405534001770 Integrase core domain; Region: rve_2; pfam13333 405534001771 Transposase; Region: HTH_Tnp_1; pfam01527 405534001772 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405534001773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 405534001774 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 405534001775 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 405534001776 Protein of unknown function DUF45; Region: DUF45; pfam01863 405534001777 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 405534001778 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 405534001779 active site 405534001780 Predicted transcriptional regulator [Transcription]; Region: COG3355 405534001781 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 405534001782 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405534001783 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 405534001784 metal binding site [ion binding]; metal-binding site 405534001785 putative dimer interface [polypeptide binding]; other site 405534001786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534001787 S-adenosylmethionine binding site [chemical binding]; other site 405534001788 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 405534001789 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 405534001790 catalytic residue [active] 405534001791 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 405534001792 catalytic residues [active] 405534001793 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405534001794 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405534001795 peroxiredoxin; Region: AhpC; TIGR03137 405534001796 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 405534001797 dimer interface [polypeptide binding]; other site 405534001798 decamer (pentamer of dimers) interface [polypeptide binding]; other site 405534001799 catalytic triad [active] 405534001800 peroxidatic and resolving cysteines [active] 405534001801 5-methylribose kinase; Reviewed; Region: PRK12396 405534001802 Phosphotransferase enzyme family; Region: APH; pfam01636 405534001803 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 405534001804 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 405534001805 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 405534001806 intersubunit interface [polypeptide binding]; other site 405534001807 active site 405534001808 Zn2+ binding site [ion binding]; other site 405534001809 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405534001810 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405534001811 ABC-ATPase subunit interface; other site 405534001812 dimer interface [polypeptide binding]; other site 405534001813 putative PBP binding regions; other site 405534001814 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405534001815 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405534001816 ABC-ATPase subunit interface; other site 405534001817 dimer interface [polypeptide binding]; other site 405534001818 putative PBP binding regions; other site 405534001819 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405534001820 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 405534001821 putative ligand binding residues [chemical binding]; other site 405534001822 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 405534001823 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405534001824 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 405534001825 DNA binding domain, excisionase family; Region: excise; TIGR01764 405534001826 Sm and related proteins; Region: Sm_like; cl00259 405534001827 Sm1 motif; other site 405534001828 RNA binding site [nucleotide binding]; other site 405534001829 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 405534001830 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 405534001831 hypothetical protein; Provisional; Region: PRK06851 405534001832 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 405534001833 Walker A motif; other site 405534001834 ATP binding site [chemical binding]; other site 405534001835 NTPase; Region: NTPase_1; cl17478 405534001836 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 405534001837 benzoate transport; Region: 2A0115; TIGR00895 405534001838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534001839 putative substrate translocation pore; other site 405534001840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534001841 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 405534001842 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 405534001843 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 405534001844 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 405534001845 [2Fe-2S] cluster binding site [ion binding]; other site 405534001846 Fatty acid desaturase; Region: FA_desaturase; pfam00487 405534001847 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 405534001848 putative di-iron ligands [ion binding]; other site 405534001849 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 405534001850 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 405534001851 DXD motif; other site 405534001852 HEAT repeats; Region: HEAT_2; pfam13646 405534001853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534001854 active site 405534001855 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 405534001856 phosphorylation site [posttranslational modification] 405534001857 intermolecular recognition site; other site 405534001858 dimerization interface [polypeptide binding]; other site 405534001859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534001860 dimer interface [polypeptide binding]; other site 405534001861 conserved gate region; other site 405534001862 putative PBP binding loops; other site 405534001863 ABC-ATPase subunit interface; other site 405534001864 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 405534001865 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405534001866 substrate binding pocket [chemical binding]; other site 405534001867 membrane-bound complex binding site; other site 405534001868 hinge residues; other site 405534001869 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405534001870 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405534001871 Walker A/P-loop; other site 405534001872 ATP binding site [chemical binding]; other site 405534001873 Q-loop/lid; other site 405534001874 ABC transporter signature motif; other site 405534001875 Walker B; other site 405534001876 D-loop; other site 405534001877 H-loop/switch region; other site 405534001878 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 405534001879 HAMP domain; Region: HAMP; pfam00672 405534001880 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405534001881 dimer interface [polypeptide binding]; other site 405534001882 putative CheW interface [polypeptide binding]; other site 405534001883 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 405534001884 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 405534001885 Ca binding site [ion binding]; other site 405534001886 active site 405534001887 catalytic site [active] 405534001888 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405534001889 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 405534001890 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405534001891 active site turn [active] 405534001892 phosphorylation site [posttranslational modification] 405534001893 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 405534001894 putative catalytic site [active] 405534001895 putative metal binding site [ion binding]; other site 405534001896 putative phosphate binding site [ion binding]; other site 405534001897 Predicted membrane protein [Function unknown]; Region: COG1511 405534001898 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 405534001899 Predicted membrane protein [Function unknown]; Region: COG1511 405534001900 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 405534001901 dinuclear metal binding motif [ion binding]; other site 405534001902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534001903 DNA topoisomerase III; Provisional; Region: PRK07726 405534001904 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 405534001905 active site 405534001906 putative interdomain interaction site [polypeptide binding]; other site 405534001907 putative metal-binding site [ion binding]; other site 405534001908 putative nucleotide binding site [chemical binding]; other site 405534001909 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 405534001910 domain I; other site 405534001911 DNA binding groove [nucleotide binding] 405534001912 phosphate binding site [ion binding]; other site 405534001913 domain II; other site 405534001914 domain III; other site 405534001915 nucleotide binding site [chemical binding]; other site 405534001916 catalytic site [active] 405534001917 domain IV; other site 405534001918 Predicted transcriptional regulators [Transcription]; Region: COG1695 405534001919 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405534001920 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 405534001921 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405534001922 FtsX-like permease family; Region: FtsX; pfam02687 405534001923 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405534001924 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405534001925 Walker A/P-loop; other site 405534001926 ATP binding site [chemical binding]; other site 405534001927 Q-loop/lid; other site 405534001928 ABC transporter signature motif; other site 405534001929 Walker B; other site 405534001930 D-loop; other site 405534001931 H-loop/switch region; other site 405534001932 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 405534001933 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 405534001934 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405534001935 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534001936 Walker A/P-loop; other site 405534001937 ATP binding site [chemical binding]; other site 405534001938 Q-loop/lid; other site 405534001939 ABC transporter signature motif; other site 405534001940 Walker B; other site 405534001941 D-loop; other site 405534001942 H-loop/switch region; other site 405534001943 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 405534001944 active site 405534001945 putative metal-binding site [ion binding]; other site 405534001946 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 405534001947 substrate binding site [chemical binding]; other site 405534001948 multimerization interface [polypeptide binding]; other site 405534001949 ATP binding site [chemical binding]; other site 405534001950 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 405534001951 thiamine phosphate binding site [chemical binding]; other site 405534001952 active site 405534001953 pyrophosphate binding site [ion binding]; other site 405534001954 Predicted esterase [General function prediction only]; Region: COG0400 405534001955 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 405534001956 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 405534001957 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 405534001958 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 405534001959 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534001960 dimerization interface [polypeptide binding]; other site 405534001961 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405534001962 dimer interface [polypeptide binding]; other site 405534001963 putative CheW interface [polypeptide binding]; other site 405534001964 Domain of unknown function DUF77; Region: DUF77; pfam01910 405534001965 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 405534001966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534001967 dimer interface [polypeptide binding]; other site 405534001968 conserved gate region; other site 405534001969 putative PBP binding loops; other site 405534001970 ABC-ATPase subunit interface; other site 405534001971 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 405534001972 NMT1/THI5 like; Region: NMT1; pfam09084 405534001973 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 405534001974 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 405534001975 Walker A/P-loop; other site 405534001976 ATP binding site [chemical binding]; other site 405534001977 Q-loop/lid; other site 405534001978 ABC transporter signature motif; other site 405534001979 Walker B; other site 405534001980 D-loop; other site 405534001981 H-loop/switch region; other site 405534001982 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405534001983 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534001984 Walker A/P-loop; other site 405534001985 ATP binding site [chemical binding]; other site 405534001986 Q-loop/lid; other site 405534001987 ABC transporter signature motif; other site 405534001988 Walker B; other site 405534001989 D-loop; other site 405534001990 H-loop/switch region; other site 405534001991 ABC transporter; Region: ABC_tran_2; pfam12848 405534001992 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405534001993 Glyco_18 domain; Region: Glyco_18; smart00636 405534001994 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 405534001995 active site 405534001996 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405534001997 Interdomain contacts; other site 405534001998 Cytokine receptor motif; other site 405534001999 CBD_II domain; Region: CBD_II; smart00637 405534002000 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 405534002001 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405534002002 catalytic residues [active] 405534002003 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534002004 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534002005 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 405534002006 H+ Antiporter protein; Region: 2A0121; TIGR00900 405534002007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534002008 putative substrate translocation pore; other site 405534002009 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534002010 non-specific DNA binding site [nucleotide binding]; other site 405534002011 salt bridge; other site 405534002012 sequence-specific DNA binding site [nucleotide binding]; other site 405534002013 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 405534002014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534002015 putative substrate translocation pore; other site 405534002016 Uncharacterized conserved protein [Function unknown]; Region: COG3379 405534002017 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 405534002018 YesK-like protein; Region: YesK; pfam14150 405534002019 prolyl-tRNA synthetase; Provisional; Region: PRK08661 405534002020 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 405534002021 dimer interface [polypeptide binding]; other site 405534002022 motif 1; other site 405534002023 active site 405534002024 motif 2; other site 405534002025 motif 3; other site 405534002026 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 405534002027 anticodon binding site; other site 405534002028 zinc-binding site [ion binding]; other site 405534002029 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 405534002030 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405534002031 nucleotide binding site [chemical binding]; other site 405534002032 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 405534002033 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 405534002034 putative metal binding site [ion binding]; other site 405534002035 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 405534002036 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 405534002037 putative metal binding site [ion binding]; other site 405534002038 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 405534002039 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 405534002040 putative metal binding site [ion binding]; other site 405534002041 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 405534002042 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 405534002043 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 405534002044 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 405534002045 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 405534002046 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405534002047 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 405534002048 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 405534002049 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 405534002050 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 405534002051 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 405534002052 Low molecular weight phosphatase family; Region: LMWPc; cd00115 405534002053 active site 405534002054 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 405534002055 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 405534002056 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 405534002057 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405534002058 Soluble P-type ATPase [General function prediction only]; Region: COG4087 405534002059 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405534002060 EamA-like transporter family; Region: EamA; pfam00892 405534002061 EamA-like transporter family; Region: EamA; pfam00892 405534002062 YhhN-like protein; Region: YhhN; pfam07947 405534002063 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405534002064 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405534002065 Catalytic site [active] 405534002066 Tetratricopeptide repeat; Region: TPR_16; pfam13432 405534002067 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405534002068 binding surface 405534002069 TPR motif; other site 405534002070 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405534002071 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405534002072 Predicted membrane protein [Function unknown]; Region: COG2510 405534002073 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 405534002074 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 405534002075 calcium/proton exchanger (cax); Region: cax; TIGR00378 405534002076 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 405534002077 YfkD-like protein; Region: YfkD; pfam14167 405534002078 Radical SAM superfamily; Region: Radical_SAM; pfam04055 405534002079 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405534002080 FeS/SAM binding site; other site 405534002081 YfkB-like domain; Region: YfkB; pfam08756 405534002082 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 405534002083 Fumarase C-terminus; Region: Fumerase_C; pfam05683 405534002084 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 405534002085 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 405534002086 NodB motif; other site 405534002087 active site 405534002088 catalytic site [active] 405534002089 Cd binding site [ion binding]; other site 405534002090 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 405534002091 endonuclease III; Region: ENDO3c; smart00478 405534002092 minor groove reading motif; other site 405534002093 helix-hairpin-helix signature motif; other site 405534002094 substrate binding pocket [chemical binding]; other site 405534002095 active site 405534002096 TRAM domain; Region: TRAM; pfam01938 405534002097 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 405534002098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534002099 S-adenosylmethionine binding site [chemical binding]; other site 405534002100 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 405534002101 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 405534002102 dimerization interface 3.5A [polypeptide binding]; other site 405534002103 active site 405534002104 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 405534002105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534002106 Walker A motif; other site 405534002107 ATP binding site [chemical binding]; other site 405534002108 Walker B motif; other site 405534002109 arginine finger; other site 405534002110 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405534002111 hypothetical protein; Validated; Region: PRK06748 405534002112 S-methylmethionine transporter; Provisional; Region: PRK11387 405534002113 acetylornithine deacetylase; Validated; Region: PRK08596 405534002114 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 405534002115 metal binding site [ion binding]; metal-binding site 405534002116 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405534002117 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534002118 non-specific DNA binding site [nucleotide binding]; other site 405534002119 salt bridge; other site 405534002120 sequence-specific DNA binding site [nucleotide binding]; other site 405534002121 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 405534002122 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 405534002123 Homeodomain-like domain; Region: HTH_23; pfam13384 405534002124 putative transposase OrfB; Reviewed; Region: PHA02517 405534002125 HTH-like domain; Region: HTH_21; pfam13276 405534002126 Integrase core domain; Region: rve; pfam00665 405534002127 Integrase core domain; Region: rve_2; pfam13333 405534002128 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 405534002129 glutaminase A; Region: Gln_ase; TIGR03814 405534002130 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 405534002131 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 405534002132 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405534002133 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405534002134 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405534002135 active site turn [active] 405534002136 phosphorylation site [posttranslational modification] 405534002137 Beta-lactamase; Region: Beta-lactamase; pfam00144 405534002138 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405534002139 Sm and related proteins; Region: Sm_like; cl00259 405534002140 heptamer interface [polypeptide binding]; other site 405534002141 Sm1 motif; other site 405534002142 hexamer interface [polypeptide binding]; other site 405534002143 RNA binding site [nucleotide binding]; other site 405534002144 Sm2 motif; other site 405534002145 Sm and related proteins; Region: Sm_like; cl00259 405534002146 heptamer interface [polypeptide binding]; other site 405534002147 Sm1 motif; other site 405534002148 hexamer interface [polypeptide binding]; other site 405534002149 RNA binding site [nucleotide binding]; other site 405534002150 Sm2 motif; other site 405534002151 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405534002152 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 405534002153 active site 405534002154 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405534002155 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 405534002156 active site 405534002157 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 405534002158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405534002159 NAD(P) binding site [chemical binding]; other site 405534002160 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 405534002161 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 405534002162 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405534002163 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405534002164 NAD(P) binding site [chemical binding]; other site 405534002165 active site 405534002166 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405534002167 active site 405534002168 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405534002169 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405534002170 active site 405534002171 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 405534002172 Pyruvate formate lyase 1; Region: PFL1; cd01678 405534002173 coenzyme A binding site [chemical binding]; other site 405534002174 active site 405534002175 catalytic residues [active] 405534002176 glycine loop; other site 405534002177 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 405534002178 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405534002179 FeS/SAM binding site; other site 405534002180 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 405534002181 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 405534002182 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 405534002183 YfhE-like protein; Region: YfhE; pfam14152 405534002184 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405534002185 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 405534002186 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 405534002187 active site 405534002188 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 405534002189 TIGR01777 family protein; Region: yfcH 405534002190 putative NAD(P) binding site [chemical binding]; other site 405534002191 putative active site [active] 405534002192 recombination regulator RecX; Provisional; Region: recX; PRK14135 405534002193 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 405534002194 YpzG-like protein; Region: YpzG; pfam14139 405534002195 Small acid-soluble spore protein K family; Region: SspK; pfam08176 405534002196 WVELL protein; Region: WVELL; pfam14043 405534002197 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 405534002198 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 405534002199 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 405534002200 minor groove reading motif; other site 405534002201 helix-hairpin-helix signature motif; other site 405534002202 substrate binding pocket [chemical binding]; other site 405534002203 active site 405534002204 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 405534002205 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 405534002206 DNA binding and oxoG recognition site [nucleotide binding] 405534002207 YgaB-like protein; Region: YgaB; pfam14182 405534002208 hypothetical protein; Provisional; Region: PRK13662 405534002209 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405534002210 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405534002211 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 405534002212 Walker A/P-loop; other site 405534002213 ATP binding site [chemical binding]; other site 405534002214 Q-loop/lid; other site 405534002215 ABC transporter signature motif; other site 405534002216 Walker B; other site 405534002217 D-loop; other site 405534002218 H-loop/switch region; other site 405534002219 Predicted membrane protein [Function unknown]; Region: COG4129 405534002220 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 405534002221 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 405534002222 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 405534002223 active site 405534002224 dimer interface [polypeptide binding]; other site 405534002225 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 405534002226 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 405534002227 active site 405534002228 FMN binding site [chemical binding]; other site 405534002229 substrate binding site [chemical binding]; other site 405534002230 3Fe-4S cluster binding site [ion binding]; other site 405534002231 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 405534002232 domain_subunit interface; other site 405534002233 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 405534002234 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405534002235 inhibitor-cofactor binding pocket; inhibition site 405534002236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534002237 catalytic residue [active] 405534002238 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 405534002239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534002240 Walker A/P-loop; other site 405534002241 ATP binding site [chemical binding]; other site 405534002242 Q-loop/lid; other site 405534002243 ABC transporter signature motif; other site 405534002244 Walker B; other site 405534002245 D-loop; other site 405534002246 H-loop/switch region; other site 405534002247 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 405534002248 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 405534002249 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 405534002250 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 405534002251 Ion channel; Region: Ion_trans_2; pfam07885 405534002252 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 405534002253 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 405534002254 catalytic triad [active] 405534002255 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 405534002256 metal binding site 2 [ion binding]; metal-binding site 405534002257 putative DNA binding helix; other site 405534002258 metal binding site 1 [ion binding]; metal-binding site 405534002259 dimer interface [polypeptide binding]; other site 405534002260 structural Zn2+ binding site [ion binding]; other site 405534002261 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 405534002262 hypothetical protein; Provisional; Region: PRK12378 405534002263 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405534002264 nudix motif; other site 405534002265 Transglycosylase; Region: Transgly; pfam00912 405534002266 Thioredoxin; Region: Thioredoxin_4; pfam13462 405534002267 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 405534002268 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 405534002269 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405534002270 epoxyqueuosine reductase; Region: TIGR00276 405534002271 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 405534002272 Putative amidase domain; Region: Amidase_6; pfam12671 405534002273 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 405534002274 PAS fold; Region: PAS_4; pfam08448 405534002275 PAS domain S-box; Region: sensory_box; TIGR00229 405534002276 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405534002277 putative active site [active] 405534002278 heme pocket [chemical binding]; other site 405534002279 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405534002280 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405534002281 metal binding site [ion binding]; metal-binding site 405534002282 active site 405534002283 I-site; other site 405534002284 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405534002285 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 405534002286 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 405534002287 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 405534002288 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405534002289 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 405534002290 catalytic residues [active] 405534002291 catalytic nucleophile [active] 405534002292 Recombinase; Region: Recombinase; pfam07508 405534002293 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 405534002294 Domain of unknown function (DUF955); Region: DUF955; cl01076 405534002295 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405534002296 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534002297 sequence-specific DNA binding site [nucleotide binding]; other site 405534002298 salt bridge; other site 405534002299 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405534002300 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534002301 non-specific DNA binding site [nucleotide binding]; other site 405534002302 salt bridge; other site 405534002303 sequence-specific DNA binding site [nucleotide binding]; other site 405534002304 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 405534002305 replicative DNA helicase; Provisional; Region: PRK06749 405534002306 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 405534002307 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 405534002308 Walker A motif; other site 405534002309 ATP binding site [chemical binding]; other site 405534002310 Walker B motif; other site 405534002311 DNA binding loops [nucleotide binding] 405534002312 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 405534002313 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 405534002314 trimer interface [polypeptide binding]; other site 405534002315 active site 405534002316 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 405534002317 YopX protein; Region: YopX; pfam09643 405534002318 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 405534002319 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 405534002320 Int/Topo IB signature motif; other site 405534002321 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 405534002322 HNH endonuclease; Region: HNH; pfam01844 405534002323 active site 405534002324 Phage terminase, small subunit; Region: Terminase_4; cl01525 405534002325 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 405534002326 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 405534002327 Phage-related protein [Function unknown]; Region: COG4695; cl01923 405534002328 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 405534002329 oligomer interface [polypeptide binding]; other site 405534002330 active site residues [active] 405534002331 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 405534002332 Phage capsid family; Region: Phage_capsid; pfam05065 405534002333 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 405534002334 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 405534002335 Phage-related minor tail protein [Function unknown]; Region: COG5280 405534002336 Phage-related protein [Function unknown]; Region: COG5412 405534002337 Phage tail protein; Region: Sipho_tail; pfam05709 405534002338 Phage tail protein; Region: Sipho_tail; cl17486 405534002339 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 405534002340 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 405534002341 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 405534002342 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 405534002343 active site 405534002344 catalytic residues [active] 405534002345 DNA binding site [nucleotide binding] 405534002346 Int/Topo IB signature motif; other site 405534002347 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 405534002348 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 405534002349 active site 405534002350 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 405534002351 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 405534002352 Protein of unknown function (DUF444); Region: DUF444; cl17371 405534002353 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405534002354 heme-binding site [chemical binding]; other site 405534002355 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 405534002356 Leucine-rich repeats; other site 405534002357 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405534002358 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405534002359 Substrate binding site [chemical binding]; other site 405534002360 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405534002361 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405534002362 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405534002363 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405534002364 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405534002365 BCCT family transporter; Region: BCCT; pfam02028 405534002366 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 405534002367 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 405534002368 FOG: PKD repeat [General function prediction only]; Region: COG3291 405534002369 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 405534002370 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 405534002371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 405534002372 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 405534002373 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 405534002374 Cache domain; Region: Cache_1; pfam02743 405534002375 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534002376 dimerization interface [polypeptide binding]; other site 405534002377 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405534002378 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405534002379 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405534002380 dimer interface [polypeptide binding]; other site 405534002381 putative CheW interface [polypeptide binding]; other site 405534002382 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 405534002383 PAS domain; Region: PAS; smart00091 405534002384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534002385 ATP binding site [chemical binding]; other site 405534002386 Mg2+ binding site [ion binding]; other site 405534002387 G-X-G motif; other site 405534002388 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 405534002389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534002390 active site 405534002391 phosphorylation site [posttranslational modification] 405534002392 intermolecular recognition site; other site 405534002393 dimerization interface [polypeptide binding]; other site 405534002394 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 405534002395 Citrate transporter; Region: CitMHS; pfam03600 405534002396 hypothetical protein; Provisional; Region: PRK12784 405534002397 NosL; Region: NosL; cl01769 405534002398 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 405534002399 Ankyrin repeat; Region: Ank; pfam00023 405534002400 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 405534002401 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 405534002402 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 405534002403 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 405534002404 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534002405 Walker A/P-loop; other site 405534002406 ATP binding site [chemical binding]; other site 405534002407 Q-loop/lid; other site 405534002408 ABC transporter signature motif; other site 405534002409 Walker B; other site 405534002410 D-loop; other site 405534002411 H-loop/switch region; other site 405534002412 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 405534002413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534002414 dimer interface [polypeptide binding]; other site 405534002415 putative PBP binding loops; other site 405534002416 ABC-ATPase subunit interface; other site 405534002417 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 405534002418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 405534002419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534002420 dimer interface [polypeptide binding]; other site 405534002421 conserved gate region; other site 405534002422 putative PBP binding loops; other site 405534002423 ABC-ATPase subunit interface; other site 405534002424 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 405534002425 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 405534002426 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405534002427 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 405534002428 active site 405534002429 metal binding site [ion binding]; metal-binding site 405534002430 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534002431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534002432 active site 405534002433 phosphorylation site [posttranslational modification] 405534002434 intermolecular recognition site; other site 405534002435 dimerization interface [polypeptide binding]; other site 405534002436 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534002437 DNA binding site [nucleotide binding] 405534002438 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534002439 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534002440 dimer interface [polypeptide binding]; other site 405534002441 phosphorylation site [posttranslational modification] 405534002442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534002443 ATP binding site [chemical binding]; other site 405534002444 Mg2+ binding site [ion binding]; other site 405534002445 G-X-G motif; other site 405534002446 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 405534002447 putative active site [active] 405534002448 EamA-like transporter family; Region: EamA; pfam00892 405534002449 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405534002450 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405534002451 DNA-binding site [nucleotide binding]; DNA binding site 405534002452 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405534002453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534002454 homodimer interface [polypeptide binding]; other site 405534002455 catalytic residue [active] 405534002456 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 405534002457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534002458 Coenzyme A binding pocket [chemical binding]; other site 405534002459 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534002460 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534002461 dimerization interface [polypeptide binding]; other site 405534002462 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534002463 dimer interface [polypeptide binding]; other site 405534002464 phosphorylation site [posttranslational modification] 405534002465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534002466 ATP binding site [chemical binding]; other site 405534002467 Mg2+ binding site [ion binding]; other site 405534002468 G-X-G motif; other site 405534002469 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534002470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534002471 active site 405534002472 phosphorylation site [posttranslational modification] 405534002473 intermolecular recognition site; other site 405534002474 dimerization interface [polypeptide binding]; other site 405534002475 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534002476 DNA binding site [nucleotide binding] 405534002477 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 405534002478 Arrestin_N terminal like; Region: LDB19; pfam13002 405534002479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534002480 Coenzyme A binding pocket [chemical binding]; other site 405534002481 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 405534002482 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 405534002483 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 405534002484 catalytic loop [active] 405534002485 iron binding site [ion binding]; other site 405534002486 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 405534002487 4Fe-4S binding domain; Region: Fer4; pfam00037 405534002488 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 405534002489 [4Fe-4S] binding site [ion binding]; other site 405534002490 molybdopterin cofactor binding site; other site 405534002491 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 405534002492 molybdopterin cofactor binding site; other site 405534002493 Uncharacterized conserved protein [Function unknown]; Region: COG2427 405534002494 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 405534002495 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 405534002496 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 405534002497 putative active site [active] 405534002498 catalytic site [active] 405534002499 putative metal binding site [ion binding]; other site 405534002500 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 405534002501 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 405534002502 hexamer interface [polypeptide binding]; other site 405534002503 ligand binding site [chemical binding]; other site 405534002504 putative active site [active] 405534002505 NAD(P) binding site [chemical binding]; other site 405534002506 amino acid transporter; Region: 2A0306; TIGR00909 405534002507 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 405534002508 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534002509 dimerization interface [polypeptide binding]; other site 405534002510 putative DNA binding site [nucleotide binding]; other site 405534002511 putative Zn2+ binding site [ion binding]; other site 405534002512 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405534002513 metal-binding site [ion binding] 405534002514 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 405534002515 Heavy-metal-associated domain; Region: HMA; pfam00403 405534002516 metal-binding site [ion binding] 405534002517 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405534002518 Soluble P-type ATPase [General function prediction only]; Region: COG4087 405534002519 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 405534002520 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 405534002521 active site 405534002522 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534002523 non-specific DNA binding site [nucleotide binding]; other site 405534002524 salt bridge; other site 405534002525 sequence-specific DNA binding site [nucleotide binding]; other site 405534002526 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405534002527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405534002528 binding surface 405534002529 TPR motif; other site 405534002530 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405534002531 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405534002532 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405534002533 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 405534002534 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 405534002535 active site 405534002536 Zn binding site [ion binding]; other site 405534002537 Uncharacterized conserved protein [Function unknown]; Region: COG0398 405534002538 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405534002539 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 405534002540 VanW like protein; Region: VanW; pfam04294 405534002541 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 405534002542 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405534002543 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405534002544 Nucleoside recognition; Region: Gate; pfam07670 405534002545 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405534002546 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534002547 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 405534002548 putative metal binding site [ion binding]; other site 405534002549 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 405534002550 Domain of unknown function DUF21; Region: DUF21; pfam01595 405534002551 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 405534002552 Transporter associated domain; Region: CorC_HlyC; smart01091 405534002553 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 405534002554 Aspartase; Region: Aspartase; cd01357 405534002555 active sites [active] 405534002556 tetramer interface [polypeptide binding]; other site 405534002557 putative transposase OrfB; Reviewed; Region: PHA02517 405534002558 HTH-like domain; Region: HTH_21; pfam13276 405534002559 Integrase core domain; Region: rve; pfam00665 405534002560 Integrase core domain; Region: rve_2; pfam13333 405534002561 Homeodomain-like domain; Region: HTH_23; pfam13384 405534002562 L-lactate permease; Region: Lactate_perm; cl00701 405534002563 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 405534002564 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534002565 dimerization interface [polypeptide binding]; other site 405534002566 putative Zn2+ binding site [ion binding]; other site 405534002567 putative DNA binding site [nucleotide binding]; other site 405534002568 acid-soluble spore protein H; Provisional; Region: sspH; PRK01625 405534002569 POT family; Region: PTR2; cl17359 405534002570 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 405534002571 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 405534002572 siderophore binding site; other site 405534002573 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405534002574 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405534002575 ABC-ATPase subunit interface; other site 405534002576 dimer interface [polypeptide binding]; other site 405534002577 putative PBP binding regions; other site 405534002578 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405534002579 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405534002580 ABC-ATPase subunit interface; other site 405534002581 dimer interface [polypeptide binding]; other site 405534002582 putative PBP binding regions; other site 405534002583 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405534002584 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405534002585 Walker A/P-loop; other site 405534002586 ATP binding site [chemical binding]; other site 405534002587 Q-loop/lid; other site 405534002588 ABC transporter signature motif; other site 405534002589 Walker B; other site 405534002590 D-loop; other site 405534002591 H-loop/switch region; other site 405534002592 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405534002593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534002594 S-adenosylmethionine binding site [chemical binding]; other site 405534002595 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 405534002596 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 405534002597 substrate-cofactor binding pocket; other site 405534002598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534002599 catalytic residue [active] 405534002600 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405534002601 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 405534002602 NAD binding site [chemical binding]; other site 405534002603 homodimer interface [polypeptide binding]; other site 405534002604 active site 405534002605 putative substrate binding site [chemical binding]; other site 405534002606 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405534002607 active site 405534002608 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405534002609 nudix motif; other site 405534002610 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 405534002611 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 405534002612 metal ion-dependent adhesion site (MIDAS); other site 405534002613 MoxR-like ATPases [General function prediction only]; Region: COG0714 405534002614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534002615 Walker A motif; other site 405534002616 ATP binding site [chemical binding]; other site 405534002617 Walker B motif; other site 405534002618 arginine finger; other site 405534002619 cardiolipin synthetase; Reviewed; Region: PRK12452 405534002620 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405534002621 putative active site [active] 405534002622 catalytic site [active] 405534002623 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 405534002624 putative active site [active] 405534002625 catalytic site [active] 405534002626 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405534002627 PAS domain; Region: PAS_9; pfam13426 405534002628 putative active site [active] 405534002629 heme pocket [chemical binding]; other site 405534002630 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405534002631 metal binding site [ion binding]; metal-binding site 405534002632 active site 405534002633 I-site; other site 405534002634 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405534002635 Amino acid permease; Region: AA_permease_2; pfam13520 405534002636 Spore germination protein; Region: Spore_permease; cl17796 405534002637 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405534002638 DNA-binding site [nucleotide binding]; DNA binding site 405534002639 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 405534002640 UTRA domain; Region: UTRA; pfam07702 405534002641 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 405534002642 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405534002643 active site turn [active] 405534002644 phosphorylation site [posttranslational modification] 405534002645 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405534002646 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 405534002647 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 405534002648 Ca binding site [ion binding]; other site 405534002649 active site 405534002650 catalytic site [active] 405534002651 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405534002652 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405534002653 Spore germination protein; Region: Spore_permease; cl17796 405534002654 Spore germination protein; Region: Spore_permease; cl17796 405534002655 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405534002656 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 405534002657 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405534002658 active site 405534002659 ATP binding site [chemical binding]; other site 405534002660 substrate binding site [chemical binding]; other site 405534002661 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405534002662 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 405534002663 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405534002664 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405534002665 Walker A/P-loop; other site 405534002666 ATP binding site [chemical binding]; other site 405534002667 Q-loop/lid; other site 405534002668 ABC transporter signature motif; other site 405534002669 Walker B; other site 405534002670 D-loop; other site 405534002671 H-loop/switch region; other site 405534002672 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 405534002673 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405534002674 substrate binding pocket [chemical binding]; other site 405534002675 membrane-bound complex binding site; other site 405534002676 hinge residues; other site 405534002677 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 405534002678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534002679 dimer interface [polypeptide binding]; other site 405534002680 conserved gate region; other site 405534002681 putative PBP binding loops; other site 405534002682 ABC-ATPase subunit interface; other site 405534002683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534002684 dimer interface [polypeptide binding]; other site 405534002685 conserved gate region; other site 405534002686 putative PBP binding loops; other site 405534002687 ABC-ATPase subunit interface; other site 405534002688 S-methylmethionine transporter; Provisional; Region: PRK11387 405534002689 OsmC-like protein; Region: OsmC; pfam02566 405534002690 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 405534002691 nucleotide binding site/active site [active] 405534002692 HIT family signature motif; other site 405534002693 catalytic residue [active] 405534002694 RNA polymerase sigma factor; Provisional; Region: PRK12542 405534002695 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405534002696 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405534002697 DNA binding residues [nucleotide binding] 405534002698 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 405534002699 Predicted transcriptional regulator [Transcription]; Region: COG2378 405534002700 HTH domain; Region: HTH_11; pfam08279 405534002701 WYL domain; Region: WYL; pfam13280 405534002702 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 405534002703 RibD C-terminal domain; Region: RibD_C; cl17279 405534002704 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 405534002705 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534002706 dimerization interface [polypeptide binding]; other site 405534002707 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534002708 dimer interface [polypeptide binding]; other site 405534002709 phosphorylation site [posttranslational modification] 405534002710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534002711 ATP binding site [chemical binding]; other site 405534002712 Mg2+ binding site [ion binding]; other site 405534002713 G-X-G motif; other site 405534002714 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534002715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534002716 active site 405534002717 phosphorylation site [posttranslational modification] 405534002718 intermolecular recognition site; other site 405534002719 dimerization interface [polypeptide binding]; other site 405534002720 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534002721 DNA binding site [nucleotide binding] 405534002722 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 405534002723 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 405534002724 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 405534002725 Sulfate transporter family; Region: Sulfate_transp; pfam00916 405534002726 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 405534002727 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 405534002728 Ligand Binding Site [chemical binding]; other site 405534002729 Protein of unknown function (DUF4027); Region: DUF4027; pfam13219 405534002730 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 405534002731 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 405534002732 peptide binding site [polypeptide binding]; other site 405534002733 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 405534002734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534002735 dimer interface [polypeptide binding]; other site 405534002736 conserved gate region; other site 405534002737 putative PBP binding loops; other site 405534002738 ABC-ATPase subunit interface; other site 405534002739 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405534002740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534002741 putative PBP binding loops; other site 405534002742 ABC-ATPase subunit interface; other site 405534002743 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 405534002744 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405534002745 Walker A/P-loop; other site 405534002746 ATP binding site [chemical binding]; other site 405534002747 Q-loop/lid; other site 405534002748 ABC transporter signature motif; other site 405534002749 Walker B; other site 405534002750 D-loop; other site 405534002751 H-loop/switch region; other site 405534002752 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 405534002753 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 405534002754 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405534002755 Walker A/P-loop; other site 405534002756 ATP binding site [chemical binding]; other site 405534002757 Q-loop/lid; other site 405534002758 ABC transporter signature motif; other site 405534002759 Walker B; other site 405534002760 D-loop; other site 405534002761 H-loop/switch region; other site 405534002762 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405534002763 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 405534002764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534002765 putative substrate translocation pore; other site 405534002766 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405534002767 MarR family; Region: MarR; pfam01047 405534002768 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 405534002769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534002770 putative substrate translocation pore; other site 405534002771 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405534002772 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405534002773 DNA binding site [nucleotide binding] 405534002774 domain linker motif; other site 405534002775 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 405534002776 dimerization interface [polypeptide binding]; other site 405534002777 ligand binding site [chemical binding]; other site 405534002778 sodium binding site [ion binding]; other site 405534002779 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405534002780 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 405534002781 substrate binding site [chemical binding]; other site 405534002782 dimer interface [polypeptide binding]; other site 405534002783 ATP binding site [chemical binding]; other site 405534002784 D-ribose pyranase; Provisional; Region: PRK11797 405534002785 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 405534002786 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 405534002787 Walker A/P-loop; other site 405534002788 ATP binding site [chemical binding]; other site 405534002789 Q-loop/lid; other site 405534002790 ABC transporter signature motif; other site 405534002791 Walker B; other site 405534002792 D-loop; other site 405534002793 H-loop/switch region; other site 405534002794 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405534002795 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405534002796 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405534002797 TM-ABC transporter signature motif; other site 405534002798 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 405534002799 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 405534002800 ligand binding site [chemical binding]; other site 405534002801 dimerization interface [polypeptide binding]; other site 405534002802 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 405534002803 active site 405534002804 intersubunit interactions; other site 405534002805 catalytic residue [active] 405534002806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 405534002807 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 405534002808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534002809 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534002810 putative substrate translocation pore; other site 405534002811 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 405534002812 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 405534002813 putative NAD(P) binding site [chemical binding]; other site 405534002814 catalytic Zn binding site [ion binding]; other site 405534002815 Ion channel; Region: Ion_trans_2; pfam07885 405534002816 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 405534002817 Zn binding site [ion binding]; other site 405534002818 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 405534002819 putative catalytic site [active] 405534002820 metal binding site A [ion binding]; metal-binding site 405534002821 phosphate binding site [ion binding]; other site 405534002822 metal binding site C [ion binding]; metal-binding site 405534002823 metal binding site B [ion binding]; metal-binding site 405534002824 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 405534002825 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 405534002826 dimer interface [polypeptide binding]; other site 405534002827 active site 405534002828 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405534002829 substrate binding site [chemical binding]; other site 405534002830 catalytic residue [active] 405534002831 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 405534002832 FAD binding domain; Region: FAD_binding_4; pfam01565 405534002833 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 405534002834 VanZ like family; Region: VanZ; pfam04892 405534002835 RDD family; Region: RDD; pfam06271 405534002836 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 405534002837 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405534002838 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405534002839 dimer interface [polypeptide binding]; other site 405534002840 putative CheW interface [polypeptide binding]; other site 405534002841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 405534002842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 405534002843 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405534002844 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534002845 non-specific DNA binding site [nucleotide binding]; other site 405534002846 salt bridge; other site 405534002847 sequence-specific DNA binding site [nucleotide binding]; other site 405534002848 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 405534002849 active site 405534002850 catalytic site [active] 405534002851 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 405534002852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534002853 putative substrate translocation pore; other site 405534002854 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405534002855 Archaeal flagella protein; Region: Arch_fla_DE; cl01322 405534002856 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 405534002857 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 405534002858 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 405534002859 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405534002860 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405534002861 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534002862 non-specific DNA binding site [nucleotide binding]; other site 405534002863 salt bridge; other site 405534002864 sequence-specific DNA binding site [nucleotide binding]; other site 405534002865 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534002866 Coenzyme A binding pocket [chemical binding]; other site 405534002867 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 405534002868 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 405534002869 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 405534002870 TrkA-N domain; Region: TrkA_N; pfam02254 405534002871 TrkA-C domain; Region: TrkA_C; pfam02080 405534002872 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 405534002873 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 405534002874 Subunit I/III interface [polypeptide binding]; other site 405534002875 Subunit III/IV interface [polypeptide binding]; other site 405534002876 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 405534002877 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 405534002878 D-pathway; other site 405534002879 Putative ubiquinol binding site [chemical binding]; other site 405534002880 Low-spin heme (heme b) binding site [chemical binding]; other site 405534002881 Putative water exit pathway; other site 405534002882 Binuclear center (heme o3/CuB) [ion binding]; other site 405534002883 K-pathway; other site 405534002884 Putative proton exit pathway; other site 405534002885 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 405534002886 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 405534002887 S-methylmethionine transporter; Provisional; Region: PRK11387 405534002888 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 405534002889 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 405534002890 putative active site [active] 405534002891 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405534002892 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 405534002893 metal binding site [ion binding]; metal-binding site 405534002894 dimer interface [polypeptide binding]; other site 405534002895 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 405534002896 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 405534002897 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 405534002898 Na binding site [ion binding]; other site 405534002899 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405534002900 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 405534002901 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405534002902 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405534002903 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 405534002904 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 405534002905 G1 box; other site 405534002906 GTP/Mg2+ binding site [chemical binding]; other site 405534002907 Switch I region; other site 405534002908 G2 box; other site 405534002909 G3 box; other site 405534002910 Switch II region; other site 405534002911 G4 box; other site 405534002912 G5 box; other site 405534002913 FeoA domain; Region: FeoA; pfam04023 405534002914 phosphate binding protein; Region: ptsS_2; TIGR02136 405534002915 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 405534002916 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 405534002917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534002918 dimer interface [polypeptide binding]; other site 405534002919 conserved gate region; other site 405534002920 putative PBP binding loops; other site 405534002921 ABC-ATPase subunit interface; other site 405534002922 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 405534002923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534002924 dimer interface [polypeptide binding]; other site 405534002925 conserved gate region; other site 405534002926 putative PBP binding loops; other site 405534002927 ABC-ATPase subunit interface; other site 405534002928 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 405534002929 FOG: CBS domain [General function prediction only]; Region: COG0517 405534002930 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 405534002931 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 405534002932 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 405534002933 Bacterial SH3 domain; Region: SH3_3; pfam08239 405534002934 Bacterial SH3 domain; Region: SH3_3; pfam08239 405534002935 Bacterial SH3 domain; Region: SH3_3; pfam08239 405534002936 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405534002937 Peptidase family M23; Region: Peptidase_M23; pfam01551 405534002938 Putative transcription activator [Transcription]; Region: TenA; COG0819 405534002939 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 405534002940 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 405534002941 Walker A/P-loop; other site 405534002942 ATP binding site [chemical binding]; other site 405534002943 Q-loop/lid; other site 405534002944 ABC transporter signature motif; other site 405534002945 Walker B; other site 405534002946 D-loop; other site 405534002947 H-loop/switch region; other site 405534002948 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 405534002949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534002950 dimer interface [polypeptide binding]; other site 405534002951 conserved gate region; other site 405534002952 putative PBP binding loops; other site 405534002953 ABC-ATPase subunit interface; other site 405534002954 NMT1/THI5 like; Region: NMT1; pfam09084 405534002955 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 405534002956 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 405534002957 thiamine phosphate binding site [chemical binding]; other site 405534002958 active site 405534002959 pyrophosphate binding site [ion binding]; other site 405534002960 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 405534002961 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 405534002962 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 405534002963 thiS-thiF/thiG interaction site; other site 405534002964 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 405534002965 ThiS interaction site; other site 405534002966 putative active site [active] 405534002967 tetramer interface [polypeptide binding]; other site 405534002968 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 405534002969 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 405534002970 ATP binding site [chemical binding]; other site 405534002971 substrate interface [chemical binding]; other site 405534002972 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 405534002973 dimer interface [polypeptide binding]; other site 405534002974 substrate binding site [chemical binding]; other site 405534002975 ATP binding site [chemical binding]; other site 405534002976 ydaO/yuaA leader 405534002977 ydaO/yuaA leader 405534002978 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 405534002979 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 405534002980 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405534002981 Soluble P-type ATPase [General function prediction only]; Region: COG4087 405534002982 potassium-transporting ATPase subunit C; Provisional; Region: PRK13997 405534002983 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 405534002984 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 405534002985 Ligand Binding Site [chemical binding]; other site 405534002986 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 405534002987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534002988 putative substrate translocation pore; other site 405534002989 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405534002990 MarR family; Region: MarR; pfam01047 405534002991 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 405534002992 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 405534002993 active site 405534002994 nucleophile elbow; other site 405534002995 FtsX-like permease family; Region: FtsX; pfam02687 405534002996 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405534002997 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405534002998 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 405534002999 FtsX-like permease family; Region: FtsX; pfam02687 405534003000 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405534003001 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405534003002 Walker A/P-loop; other site 405534003003 ATP binding site [chemical binding]; other site 405534003004 Q-loop/lid; other site 405534003005 ABC transporter signature motif; other site 405534003006 Walker B; other site 405534003007 D-loop; other site 405534003008 H-loop/switch region; other site 405534003009 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405534003010 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405534003011 TM-ABC transporter signature motif; other site 405534003012 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 405534003013 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 405534003014 Walker A/P-loop; other site 405534003015 ATP binding site [chemical binding]; other site 405534003016 Q-loop/lid; other site 405534003017 ABC transporter signature motif; other site 405534003018 Walker B; other site 405534003019 D-loop; other site 405534003020 H-loop/switch region; other site 405534003021 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405534003022 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 405534003023 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 405534003024 putative ligand binding site [chemical binding]; other site 405534003025 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405534003026 short chain dehydrogenase; Provisional; Region: PRK06701 405534003027 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 405534003028 NAD binding site [chemical binding]; other site 405534003029 metal binding site [ion binding]; metal-binding site 405534003030 active site 405534003031 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405534003032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 405534003033 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405534003034 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 405534003035 putative substrate binding site [chemical binding]; other site 405534003036 putative ATP binding site [chemical binding]; other site 405534003037 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 405534003038 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 405534003039 substrate binding [chemical binding]; other site 405534003040 active site 405534003041 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 405534003042 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 405534003043 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405534003044 active site turn [active] 405534003045 phosphorylation site [posttranslational modification] 405534003046 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405534003047 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405534003048 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405534003049 DNA binding site [nucleotide binding] 405534003050 domain linker motif; other site 405534003051 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 405534003052 dimerization interface [polypeptide binding]; other site 405534003053 ligand binding site [chemical binding]; other site 405534003054 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405534003055 catalytic residues [active] 405534003056 putative disulfide oxidoreductase; Provisional; Region: PRK03113 405534003057 YhdB-like protein; Region: YhdB; pfam14148 405534003058 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 405534003059 Spore germination protein; Region: Spore_permease; cl17796 405534003060 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405534003061 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405534003062 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405534003063 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 405534003064 putative FMN binding site [chemical binding]; other site 405534003065 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 405534003066 SpoVR like protein; Region: SpoVR; pfam04293 405534003067 HerA helicase [Replication, recombination, and repair]; Region: COG0433 405534003068 Domain of unknown function DUF87; Region: DUF87; pfam01935 405534003069 AAA domain; Region: AAA_21; pfam13304 405534003070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534003071 Walker B; other site 405534003072 D-loop; other site 405534003073 H-loop/switch region; other site 405534003074 High molecular weight glutenin subunit; Region: Glutenin_hmw; pfam03157 405534003075 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 405534003076 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 405534003077 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405534003078 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405534003079 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405534003080 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 405534003081 active site residue [active] 405534003082 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 405534003083 putative homodimer interface [polypeptide binding]; other site 405534003084 putative homotetramer interface [polypeptide binding]; other site 405534003085 putative metal binding site [ion binding]; other site 405534003086 putative homodimer-homodimer interface [polypeptide binding]; other site 405534003087 putative allosteric switch controlling residues; other site 405534003088 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 405534003089 CPxP motif; other site 405534003090 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405534003091 active site residue [active] 405534003092 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 405534003093 active site residue [active] 405534003094 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405534003095 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 405534003096 CPxP motif; other site 405534003097 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 405534003098 CPxP motif; other site 405534003099 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405534003100 active site residue [active] 405534003101 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 405534003102 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405534003103 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 405534003104 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 405534003105 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 405534003106 NADP binding site [chemical binding]; other site 405534003107 dimer interface [polypeptide binding]; other site 405534003108 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 405534003109 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 405534003110 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 405534003111 PhoU domain; Region: PhoU; pfam01895 405534003112 PhoU domain; Region: PhoU; pfam01895 405534003113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534003114 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534003115 putative substrate translocation pore; other site 405534003116 Uncharacterized conserved protein [Function unknown]; Region: COG3589 405534003117 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 405534003118 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 405534003119 HTH domain; Region: HTH_11; pfam08279 405534003120 Mga helix-turn-helix domain; Region: Mga; pfam05043 405534003121 PRD domain; Region: PRD; pfam00874 405534003122 PRD domain; Region: PRD; pfam00874 405534003123 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 405534003124 active site 405534003125 P-loop; other site 405534003126 phosphorylation site [posttranslational modification] 405534003127 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 405534003128 active site 405534003129 phosphorylation site [posttranslational modification] 405534003130 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 405534003131 active site 405534003132 methionine cluster; other site 405534003133 phosphorylation site [posttranslational modification] 405534003134 metal binding site [ion binding]; metal-binding site 405534003135 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 405534003136 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 405534003137 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 405534003138 Uncharacterized conserved protein [Function unknown]; Region: COG3589 405534003139 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 405534003140 Bacterial SH3 domain; Region: SH3_3; pfam08239 405534003141 Bacterial SH3 domain; Region: SH3_3; pfam08239 405534003142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 405534003143 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 405534003144 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405534003145 FtsX-like permease family; Region: FtsX; pfam02687 405534003146 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405534003147 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405534003148 Walker A/P-loop; other site 405534003149 ATP binding site [chemical binding]; other site 405534003150 Q-loop/lid; other site 405534003151 ABC transporter signature motif; other site 405534003152 Walker B; other site 405534003153 D-loop; other site 405534003154 H-loop/switch region; other site 405534003155 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 405534003156 HlyD family secretion protein; Region: HlyD_3; pfam13437 405534003157 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 405534003158 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 405534003159 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405534003160 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405534003161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534003162 dimer interface [polypeptide binding]; other site 405534003163 conserved gate region; other site 405534003164 ABC-ATPase subunit interface; other site 405534003165 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405534003166 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 405534003167 dimanganese center [ion binding]; other site 405534003168 CotJB protein; Region: CotJB; pfam12652 405534003169 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 405534003170 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534003171 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405534003172 active site 405534003173 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 405534003174 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 405534003175 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 405534003176 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666 405534003177 DNA binding site [nucleotide binding] 405534003178 heterodimer interface [polypeptide binding]; other site 405534003179 yybP-ykoY leader 405534003180 Uncharacterized conserved protein [Function unknown]; Region: COG3339 405534003181 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405534003182 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405534003183 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405534003184 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 405534003185 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 405534003186 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 405534003187 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405534003188 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 405534003189 active site 405534003190 metal binding site [ion binding]; metal-binding site 405534003191 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405534003192 Interdomain contacts; other site 405534003193 Cytokine receptor motif; other site 405534003194 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 405534003195 amino acid transporter; Region: 2A0306; TIGR00909 405534003196 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 405534003197 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 405534003198 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 405534003199 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 405534003200 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 405534003201 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 405534003202 putative active site [active] 405534003203 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 405534003204 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 405534003205 putative active site [active] 405534003206 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405534003207 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 405534003208 active site turn [active] 405534003209 phosphorylation site [posttranslational modification] 405534003210 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405534003211 Uncharacterized conserved protein [Function unknown]; Region: COG3589 405534003212 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 405534003213 DoxX; Region: DoxX; pfam07681 405534003214 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 405534003215 hypothetical protein; Provisional; Region: PRK06770 405534003216 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405534003217 EamA-like transporter family; Region: EamA; pfam00892 405534003218 EamA-like transporter family; Region: EamA; pfam00892 405534003219 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 405534003220 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 405534003221 AsnC family; Region: AsnC_trans_reg; pfam01037 405534003222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534003223 Coenzyme A binding pocket [chemical binding]; other site 405534003224 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405534003225 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405534003226 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534003227 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534003228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534003229 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534003230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534003231 Predicted transcriptional regulators [Transcription]; Region: COG1733 405534003232 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 405534003233 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405534003234 MarR family; Region: MarR; pfam01047 405534003235 hypothetical protein; Provisional; Region: PRK06847 405534003236 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 405534003237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534003238 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 405534003239 putative substrate translocation pore; other site 405534003240 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 405534003241 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 405534003242 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 405534003243 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 405534003244 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405534003245 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534003246 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534003247 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 405534003248 Cytochrome P450; Region: p450; cl12078 405534003249 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 405534003250 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534003251 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 405534003252 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 405534003253 putative NAD(P) binding site [chemical binding]; other site 405534003254 catalytic Zn binding site [ion binding]; other site 405534003255 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405534003256 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405534003257 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534003258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534003259 Uncharacterized conserved protein [Function unknown]; Region: COG1683 405534003260 CAAX protease self-immunity; Region: Abi; cl00558 405534003261 hypothetical protein; Provisional; Region: PRK12856 405534003262 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 405534003263 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 405534003264 putative active site [active] 405534003265 putative NTP binding site [chemical binding]; other site 405534003266 putative nucleic acid binding site [nucleotide binding]; other site 405534003267 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 405534003268 active site 405534003269 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 405534003270 Predicted transcriptional regulators [Transcription]; Region: COG1733 405534003271 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 405534003272 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 405534003273 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405534003274 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 405534003275 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 405534003276 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 405534003277 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 405534003278 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534003279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534003280 putative substrate translocation pore; other site 405534003281 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 405534003282 conserved cys residue [active] 405534003283 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 405534003284 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 405534003285 Lysine riboswitch 405534003286 glutamate racemase; Provisional; Region: PRK00865 405534003287 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 405534003288 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 405534003289 tetrameric interface [polypeptide binding]; other site 405534003290 activator binding site; other site 405534003291 NADP binding site [chemical binding]; other site 405534003292 substrate binding site [chemical binding]; other site 405534003293 catalytic residues [active] 405534003294 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405534003295 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 405534003296 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534003297 Walker A/P-loop; other site 405534003298 ATP binding site [chemical binding]; other site 405534003299 Q-loop/lid; other site 405534003300 ABC transporter signature motif; other site 405534003301 Walker B; other site 405534003302 D-loop; other site 405534003303 H-loop/switch region; other site 405534003304 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405534003305 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 405534003306 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 405534003307 Walker A/P-loop; other site 405534003308 ATP binding site [chemical binding]; other site 405534003309 Q-loop/lid; other site 405534003310 ABC transporter signature motif; other site 405534003311 Walker B; other site 405534003312 D-loop; other site 405534003313 H-loop/switch region; other site 405534003314 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 405534003315 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405534003316 substrate binding pocket [chemical binding]; other site 405534003317 membrane-bound complex binding site; other site 405534003318 hinge residues; other site 405534003319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534003320 dimer interface [polypeptide binding]; other site 405534003321 conserved gate region; other site 405534003322 putative PBP binding loops; other site 405534003323 ABC-ATPase subunit interface; other site 405534003324 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405534003325 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405534003326 Walker A/P-loop; other site 405534003327 ATP binding site [chemical binding]; other site 405534003328 Q-loop/lid; other site 405534003329 ABC transporter signature motif; other site 405534003330 Walker B; other site 405534003331 D-loop; other site 405534003332 H-loop/switch region; other site 405534003333 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405534003334 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 405534003335 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 405534003336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 405534003337 hypothetical protein; Provisional; Region: PRK13676 405534003338 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 405534003339 acetolactate synthase; Reviewed; Region: PRK08617 405534003340 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 405534003341 PYR/PP interface [polypeptide binding]; other site 405534003342 dimer interface [polypeptide binding]; other site 405534003343 TPP binding site [chemical binding]; other site 405534003344 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405534003345 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 405534003346 TPP-binding site [chemical binding]; other site 405534003347 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 405534003348 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 405534003349 active site 405534003350 DNA binding site [nucleotide binding] 405534003351 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 405534003352 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405534003353 active site 405534003354 motif I; other site 405534003355 motif II; other site 405534003356 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 405534003357 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405534003358 amidase catalytic site [active] 405534003359 Zn binding residues [ion binding]; other site 405534003360 substrate binding site [chemical binding]; other site 405534003361 S-layer homology domain; Region: SLH; pfam00395 405534003362 S-layer homology domain; Region: SLH; pfam00395 405534003363 S-layer homology domain; Region: SLH; pfam00395 405534003364 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 405534003365 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405534003366 FeS/SAM binding site; other site 405534003367 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 405534003368 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405534003369 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 405534003370 acyl-activating enzyme (AAE) consensus motif; other site 405534003371 acyl-activating enzyme (AAE) consensus motif; other site 405534003372 putative AMP binding site [chemical binding]; other site 405534003373 putative active site [active] 405534003374 putative CoA binding site [chemical binding]; other site 405534003375 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 405534003376 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 405534003377 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 405534003378 putative active site [active] 405534003379 putative NTP binding site [chemical binding]; other site 405534003380 putative nucleic acid binding site [nucleotide binding]; other site 405534003381 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 405534003382 active site 405534003383 Collagen binding domain; Region: Collagen_bind; pfam05737 405534003384 Cna protein B-type domain; Region: Cna_B; pfam05738 405534003385 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 405534003386 domain interaction interfaces [polypeptide binding]; other site 405534003387 putative transporter; Provisional; Region: PRK11660 405534003388 Sulfate transporter family; Region: Sulfate_transp; pfam00916 405534003389 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 405534003390 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 405534003391 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 405534003392 ATP binding site [chemical binding]; other site 405534003393 putative Mg++ binding site [ion binding]; other site 405534003394 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 405534003395 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405534003396 nucleotide binding region [chemical binding]; other site 405534003397 ATP-binding site [chemical binding]; other site 405534003398 stage V sporulation protein B; Region: spore_V_B; TIGR02900 405534003399 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405534003400 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 405534003401 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 405534003402 S-layer homology domain; Region: SLH; pfam00395 405534003403 S-layer homology domain; Region: SLH; pfam00395 405534003404 S-layer homology domain; Region: SLH; pfam00395 405534003405 Bacterial Ig-like domain; Region: Big_5; pfam13205 405534003406 S-layer homology domain; Region: SLH; pfam00395 405534003407 S-layer homology domain; Region: SLH; pfam00395 405534003408 S-layer homology domain; Region: SLH; pfam00395 405534003409 DHHW protein; Region: DHHW; pfam14286 405534003410 DHHW protein; Region: DHHW; pfam14286 405534003411 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 405534003412 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 405534003413 enoyl-CoA hydratase; Provisional; Region: PRK07659 405534003414 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405534003415 substrate binding site [chemical binding]; other site 405534003416 oxyanion hole (OAH) forming residues; other site 405534003417 trimer interface [polypeptide binding]; other site 405534003418 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 405534003419 DNA binding residues [nucleotide binding] 405534003420 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 405534003421 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 405534003422 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405534003423 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 405534003424 metal binding site [ion binding]; metal-binding site 405534003425 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 405534003426 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 405534003427 putative oligomer interface [polypeptide binding]; other site 405534003428 putative active site [active] 405534003429 metal binding site [ion binding]; metal-binding site 405534003430 S-layer homology domain; Region: SLH; pfam00395 405534003431 S-layer homology domain; Region: SLH; pfam00395 405534003432 S-layer homology domain; Region: SLH; pfam00395 405534003433 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 405534003434 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405534003435 active site 405534003436 metal binding site [ion binding]; metal-binding site 405534003437 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 405534003438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534003439 S-adenosylmethionine binding site [chemical binding]; other site 405534003440 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 405534003441 proline racemase; Provisional; Region: PRK13969 405534003442 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 405534003443 ornithine cyclodeaminase; Validated; Region: PRK08618 405534003444 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 405534003445 NAD(P) binding site [chemical binding]; other site 405534003446 hypothetical protein; Provisional; Region: PRK06770 405534003447 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 405534003448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534003449 putative substrate translocation pore; other site 405534003450 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 405534003451 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 405534003452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534003453 ATP binding site [chemical binding]; other site 405534003454 Mg2+ binding site [ion binding]; other site 405534003455 G-X-G motif; other site 405534003456 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 405534003457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534003458 active site 405534003459 phosphorylation site [posttranslational modification] 405534003460 intermolecular recognition site; other site 405534003461 dimerization interface [polypeptide binding]; other site 405534003462 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 405534003463 Restriction endonuclease; Region: Mrr_cat; pfam04471 405534003464 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 405534003465 Part of AAA domain; Region: AAA_19; pfam13245 405534003466 Family description; Region: UvrD_C_2; pfam13538 405534003467 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 405534003468 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 405534003469 putative metal binding site [ion binding]; other site 405534003470 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 405534003471 putative metal binding site [ion binding]; other site 405534003472 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 405534003473 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 405534003474 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 405534003475 Protein of unknown function (DUF524); Region: DUF524; pfam04411 405534003476 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 405534003477 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 405534003478 Protein of unknown function DUF45; Region: DUF45; pfam01863 405534003479 Tic20-like protein; Region: Tic20; pfam09685 405534003480 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 405534003481 DNA binding residues [nucleotide binding] 405534003482 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405534003483 dimer interface [polypeptide binding]; other site 405534003484 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 405534003485 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 405534003486 metal binding site [ion binding]; metal-binding site 405534003487 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 405534003488 replicative DNA helicase; Provisional; Region: PRK06749 405534003489 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 405534003490 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 405534003491 Walker A motif; other site 405534003492 ATP binding site [chemical binding]; other site 405534003493 Walker B motif; other site 405534003494 DNA binding loops [nucleotide binding] 405534003495 Predicted transcriptional regulators [Transcription]; Region: COG1378 405534003496 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 405534003497 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 405534003498 C-terminal domain interface [polypeptide binding]; other site 405534003499 sugar binding site [chemical binding]; other site 405534003500 hypothetical protein; Provisional; Region: PRK10621 405534003501 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405534003502 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534003503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534003504 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 405534003505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534003506 putative substrate translocation pore; other site 405534003507 Predicted permease; Region: DUF318; cl17795 405534003508 Predicted permease; Region: DUF318; cl17795 405534003509 Predicted transcriptional regulators [Transcription]; Region: COG1695 405534003510 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405534003511 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 405534003512 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 405534003513 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 405534003514 CGNR zinc finger; Region: zf-CGNR; pfam11706 405534003515 HPP family; Region: HPP; pfam04982 405534003516 YmzC-like protein; Region: YmzC; pfam14157 405534003517 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 405534003518 Transcriptional regulators [Transcription]; Region: MarR; COG1846 405534003519 MarR family; Region: MarR_2; pfam12802 405534003520 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 405534003521 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 405534003522 ATP synthase I chain; Region: ATP_synt_I; pfam03899 405534003523 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 405534003524 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 405534003525 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 405534003526 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 405534003527 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534003528 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 405534003529 dihydroxyacetone kinase; Provisional; Region: PRK14479 405534003530 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 405534003531 DAK2 domain; Region: Dak2; pfam02734 405534003532 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 405534003533 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405534003534 Zn2+ binding site [ion binding]; other site 405534003535 Mg2+ binding site [ion binding]; other site 405534003536 S-layer homology domain; Region: SLH; pfam00395 405534003537 S-layer homology domain; Region: SLH; pfam00395 405534003538 S-layer homology domain; Region: SLH; pfam00395 405534003539 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 405534003540 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 405534003541 Predicted transcriptional regulators [Transcription]; Region: COG1695 405534003542 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405534003543 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 405534003544 S-layer homology domain; Region: SLH; pfam00395 405534003545 S-layer homology domain; Region: SLH; pfam00395 405534003546 S-layer homology domain; Region: SLH; pfam00395 405534003547 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534003548 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405534003549 active site 405534003550 Heat induced stress protein YflT; Region: YflT; pfam11181 405534003551 Predicted membrane protein [Function unknown]; Region: COG2261 405534003552 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 405534003553 anti sigma factor interaction site; other site 405534003554 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 405534003555 regulatory phosphorylation site [posttranslational modification]; other site 405534003556 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 405534003557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534003558 ATP binding site [chemical binding]; other site 405534003559 Mg2+ binding site [ion binding]; other site 405534003560 G-X-G motif; other site 405534003561 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 405534003562 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405534003563 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 405534003564 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405534003565 DNA binding residues [nucleotide binding] 405534003566 Ferritin-like domain; Region: Ferritin; pfam00210 405534003567 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 405534003568 dinuclear metal binding motif [ion binding]; other site 405534003569 Response regulator receiver domain; Region: Response_reg; pfam00072 405534003570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534003571 active site 405534003572 phosphorylation site [posttranslational modification] 405534003573 intermolecular recognition site; other site 405534003574 dimerization interface [polypeptide binding]; other site 405534003575 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 405534003576 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 405534003577 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 405534003578 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 405534003579 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 405534003580 CHASE3 domain; Region: CHASE3; pfam05227 405534003581 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 405534003582 GAF domain; Region: GAF; pfam01590 405534003583 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534003584 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534003585 dimer interface [polypeptide binding]; other site 405534003586 phosphorylation site [posttranslational modification] 405534003587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534003588 ATP binding site [chemical binding]; other site 405534003589 Mg2+ binding site [ion binding]; other site 405534003590 G-X-G motif; other site 405534003591 Response regulator receiver domain; Region: Response_reg; pfam00072 405534003592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534003593 active site 405534003594 phosphorylation site [posttranslational modification] 405534003595 intermolecular recognition site; other site 405534003596 dimerization interface [polypeptide binding]; other site 405534003597 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 405534003598 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 405534003599 hypothetical protein; Provisional; Region: PRK12856 405534003600 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405534003601 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 405534003602 NADP binding site [chemical binding]; other site 405534003603 dimer interface [polypeptide binding]; other site 405534003604 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 405534003605 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 405534003606 YhzD-like protein; Region: YhzD; pfam14120 405534003607 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 405534003608 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405534003609 active site 405534003610 metal binding site [ion binding]; metal-binding site 405534003611 DNA binding site [nucleotide binding] 405534003612 AAA domain; Region: AAA_27; pfam13514 405534003613 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534003614 Q-loop/lid; other site 405534003615 ABC transporter signature motif; other site 405534003616 Walker B; other site 405534003617 D-loop; other site 405534003618 H-loop/switch region; other site 405534003619 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 405534003620 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 405534003621 generic binding surface I; other site 405534003622 generic binding surface II; other site 405534003623 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405534003624 Zn2+ binding site [ion binding]; other site 405534003625 Mg2+ binding site [ion binding]; other site 405534003626 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534003627 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534003628 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 405534003629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534003630 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 405534003631 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534003632 Zn binding site [ion binding]; other site 405534003633 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 405534003634 Zn binding site [ion binding]; other site 405534003635 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 405534003636 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534003637 Zn binding site [ion binding]; other site 405534003638 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 405534003639 Zn binding site [ion binding]; other site 405534003640 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; pfam09965 405534003641 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405534003642 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 405534003643 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 405534003644 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 405534003645 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 405534003646 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 405534003647 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 405534003648 amphipathic channel; other site 405534003649 Asn-Pro-Ala signature motifs; other site 405534003650 glycerol kinase; Provisional; Region: glpK; PRK00047 405534003651 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 405534003652 N- and C-terminal domain interface [polypeptide binding]; other site 405534003653 active site 405534003654 MgATP binding site [chemical binding]; other site 405534003655 catalytic site [active] 405534003656 metal binding site [ion binding]; metal-binding site 405534003657 glycerol binding site [chemical binding]; other site 405534003658 homotetramer interface [polypeptide binding]; other site 405534003659 homodimer interface [polypeptide binding]; other site 405534003660 FBP binding site [chemical binding]; other site 405534003661 protein IIAGlc interface [polypeptide binding]; other site 405534003662 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 405534003663 HTH-like domain; Region: HTH_21; pfam13276 405534003664 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 405534003665 Integrase core domain; Region: rve; pfam00665 405534003666 Integrase core domain; Region: rve_2; pfam13333 405534003667 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405534003668 Helix-turn-helix domain; Region: HTH_28; pfam13518 405534003669 Helix-turn-helix domain; Region: HTH_28; pfam13518 405534003670 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 405534003671 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405534003672 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405534003673 DNA binding residues [nucleotide binding] 405534003674 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 405534003675 Predicted transcriptional regulators [Transcription]; Region: COG1695 405534003676 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 405534003677 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 405534003678 Part of AAA domain; Region: AAA_19; pfam13245 405534003679 Family description; Region: UvrD_C_2; pfam13538 405534003680 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 405534003681 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 405534003682 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 405534003683 transcriptional regulator Hpr; Provisional; Region: PRK13777 405534003684 MarR family; Region: MarR; pfam01047 405534003685 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 405534003686 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 405534003687 HIT family signature motif; other site 405534003688 catalytic residue [active] 405534003689 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405534003690 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405534003691 Walker A/P-loop; other site 405534003692 ATP binding site [chemical binding]; other site 405534003693 Q-loop/lid; other site 405534003694 ABC transporter signature motif; other site 405534003695 Walker B; other site 405534003696 D-loop; other site 405534003697 H-loop/switch region; other site 405534003698 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 405534003699 EcsC protein family; Region: EcsC; pfam12787 405534003700 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534003701 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534003702 Uncharacterized conserved protein [Function unknown]; Region: COG3402 405534003703 Predicted membrane protein [Function unknown]; Region: COG3428 405534003704 Bacterial PH domain; Region: DUF304; pfam03703 405534003705 Bacterial PH domain; Region: DUF304; cl01348 405534003706 Bacterial PH domain; Region: DUF304; pfam03703 405534003707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 405534003708 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 405534003709 MAEBL; Provisional; Region: PTZ00121 405534003710 Uncharacterized conserved protein [Function unknown]; Region: COG3402 405534003711 Predicted membrane protein [Function unknown]; Region: COG3428 405534003712 Bacterial PH domain; Region: DUF304; pfam03703 405534003713 Bacterial PH domain; Region: DUF304; pfam03703 405534003714 Bacterial PH domain; Region: DUF304; pfam03703 405534003715 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 405534003716 Transglycosylase; Region: Transgly; pfam00912 405534003717 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 405534003718 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405534003719 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 405534003720 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 405534003721 substrate binding site [chemical binding]; other site 405534003722 active site 405534003723 ferrochelatase; Provisional; Region: PRK12435 405534003724 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 405534003725 C-terminal domain interface [polypeptide binding]; other site 405534003726 active site 405534003727 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 405534003728 active site 405534003729 N-terminal domain interface [polypeptide binding]; other site 405534003730 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 405534003731 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405534003732 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405534003733 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 405534003734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 405534003735 Fn3 associated; Region: Fn3_assoc; pfam13287 405534003736 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 405534003737 generic binding surface II; other site 405534003738 generic binding surface I; other site 405534003739 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 405534003740 putative active site [active] 405534003741 putative catalytic site [active] 405534003742 putative Mg binding site IVb [ion binding]; other site 405534003743 putative phosphate binding site [ion binding]; other site 405534003744 putative DNA binding site [nucleotide binding]; other site 405534003745 putative Mg binding site IVa [ion binding]; other site 405534003746 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534003747 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534003748 Predicted membrane protein [Function unknown]; Region: COG1511 405534003749 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 405534003750 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 405534003751 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 405534003752 trimer interface [polypeptide binding]; other site 405534003753 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 405534003754 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 405534003755 DinB superfamily; Region: DinB_2; pfam12867 405534003756 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 405534003757 Predicted transcriptional regulator [Transcription]; Region: COG2378 405534003758 HTH domain; Region: HTH_11; pfam08279 405534003759 WYL domain; Region: WYL; pfam13280 405534003760 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405534003761 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405534003762 DNA binding site [nucleotide binding] 405534003763 domain linker motif; other site 405534003764 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 405534003765 putative dimerization interface [polypeptide binding]; other site 405534003766 putative ligand binding site [chemical binding]; other site 405534003767 YhfH-like protein; Region: YhfH; pfam14149 405534003768 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 405534003769 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 405534003770 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 405534003771 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 405534003772 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 405534003773 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 405534003774 acyl-activating enzyme (AAE) consensus motif; other site 405534003775 putative AMP binding site [chemical binding]; other site 405534003776 putative active site [active] 405534003777 putative CoA binding site [chemical binding]; other site 405534003778 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405534003779 heme-binding site [chemical binding]; other site 405534003780 S-layer homology domain; Region: SLH; pfam00395 405534003781 S-layer homology domain; Region: SLH; pfam00395 405534003782 S-layer homology domain; Region: SLH; pfam00395 405534003783 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 405534003784 RHS Repeat; Region: RHS_repeat; pfam05593 405534003785 RHS protein; Region: RHS; pfam03527 405534003786 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 405534003787 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 405534003788 RHS Repeat; Region: RHS_repeat; cl11982 405534003789 RHS protein; Region: RHS; pfam03527 405534003790 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 405534003791 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 405534003792 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 405534003793 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 405534003794 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534003795 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405534003796 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405534003797 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405534003798 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 405534003799 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405534003800 putative active site [active] 405534003801 putative metal binding site [ion binding]; other site 405534003802 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405534003803 Zn2+ binding site [ion binding]; other site 405534003804 Mg2+ binding site [ion binding]; other site 405534003805 Putative zinc-finger; Region: zf-HC2; pfam13490 405534003806 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 405534003807 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 405534003808 RNA polymerase sigma factor; Provisional; Region: PRK12541 405534003809 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405534003810 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405534003811 DNA binding residues [nucleotide binding] 405534003812 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405534003813 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405534003814 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405534003815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 405534003816 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405534003817 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534003818 active site 405534003819 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534003820 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534003821 dimer interface [polypeptide binding]; other site 405534003822 phosphorylation site [posttranslational modification] 405534003823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534003824 ATP binding site [chemical binding]; other site 405534003825 Mg2+ binding site [ion binding]; other site 405534003826 G-X-G motif; other site 405534003827 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534003828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534003829 active site 405534003830 phosphorylation site [posttranslational modification] 405534003831 intermolecular recognition site; other site 405534003832 dimerization interface [polypeptide binding]; other site 405534003833 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534003834 DNA binding site [nucleotide binding] 405534003835 CAAX protease self-immunity; Region: Abi; pfam02517 405534003836 Peptidase family M48; Region: Peptidase_M48; pfam01435 405534003837 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405534003838 EamA-like transporter family; Region: EamA; pfam00892 405534003839 EamA-like transporter family; Region: EamA; pfam00892 405534003840 S-layer homology domain; Region: SLH; pfam00395 405534003841 S-layer homology domain; Region: SLH; pfam00395 405534003842 S-layer homology domain; Region: SLH; pfam00395 405534003843 S-layer homology domain; Region: SLH; pfam00395 405534003844 S-layer homology domain; Region: SLH; pfam00395 405534003845 S-layer homology domain; Region: SLH; pfam00395 405534003846 S-layer homology domain; Region: SLH; pfam00395 405534003847 S-layer homology domain; Region: SLH; pfam00395 405534003848 S-layer homology domain; Region: SLH; pfam00395 405534003849 malate synthase A; Region: malate_syn_A; TIGR01344 405534003850 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 405534003851 active site 405534003852 isocitrate lyase; Provisional; Region: PRK15063 405534003853 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 405534003854 tetramer interface [polypeptide binding]; other site 405534003855 active site 405534003856 Mg2+/Mn2+ binding site [ion binding]; other site 405534003857 Phosphotransferase enzyme family; Region: APH; pfam01636 405534003858 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 405534003859 active site 405534003860 substrate binding site [chemical binding]; other site 405534003861 ATP binding site [chemical binding]; other site 405534003862 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405534003863 DNA-binding site [nucleotide binding]; DNA binding site 405534003864 RNA-binding motif; other site 405534003865 ComK protein; Region: ComK; pfam06338 405534003866 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 405534003867 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 405534003868 Uncharacterized conserved protein [Function unknown]; Region: COG0398 405534003869 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405534003870 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405534003871 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405534003872 Catalytic site [active] 405534003873 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405534003874 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 405534003875 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 405534003876 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 405534003877 Part of AAA domain; Region: AAA_19; pfam13245 405534003878 Family description; Region: UvrD_C_2; pfam13538 405534003879 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 405534003880 hypothetical protein; Provisional; Region: PRK07758 405534003881 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 405534003882 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 405534003883 Spore germination protein GerPC; Region: GerPC; pfam10737 405534003884 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 405534003885 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 405534003886 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 405534003887 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 405534003888 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 405534003889 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 405534003890 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405534003891 inhibitor-cofactor binding pocket; inhibition site 405534003892 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534003893 catalytic residue [active] 405534003894 hypothetical protein; Provisional; Region: PRK13673 405534003895 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 405534003896 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 405534003897 active site 405534003898 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 405534003899 dimer interface [polypeptide binding]; other site 405534003900 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 405534003901 Ligand Binding Site [chemical binding]; other site 405534003902 Molecular Tunnel; other site 405534003903 ferrochelatase; Provisional; Region: PRK12435 405534003904 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 405534003905 C-terminal domain interface [polypeptide binding]; other site 405534003906 active site 405534003907 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 405534003908 active site 405534003909 N-terminal domain interface [polypeptide binding]; other site 405534003910 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 405534003911 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 405534003912 tetramer interface [polypeptide binding]; other site 405534003913 heme binding pocket [chemical binding]; other site 405534003914 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 405534003915 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 405534003916 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 405534003917 active site 405534003918 catalytic site [active] 405534003919 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405534003920 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534003921 non-specific DNA binding site [nucleotide binding]; other site 405534003922 salt bridge; other site 405534003923 sequence-specific DNA binding site [nucleotide binding]; other site 405534003924 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405534003925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 405534003926 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 405534003927 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 405534003928 S1 domain; Region: S1_2; pfam13509 405534003929 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 405534003930 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 405534003931 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405534003932 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405534003933 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405534003934 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405534003935 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 405534003936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534003937 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405534003938 active site 405534003939 motif I; other site 405534003940 motif II; other site 405534003941 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 405534003942 YjzC-like protein; Region: YjzC; pfam14168 405534003943 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 405534003944 Clp amino terminal domain; Region: Clp_N; pfam02861 405534003945 Clp amino terminal domain; Region: Clp_N; pfam02861 405534003946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534003947 Walker A motif; other site 405534003948 ATP binding site [chemical binding]; other site 405534003949 Walker B motif; other site 405534003950 arginine finger; other site 405534003951 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534003952 Walker A motif; other site 405534003953 ATP binding site [chemical binding]; other site 405534003954 Walker B motif; other site 405534003955 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 405534003956 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 405534003957 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 405534003958 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 405534003959 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 405534003960 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405534003961 NAD(P) binding site [chemical binding]; other site 405534003962 active site 405534003963 ComZ; Region: ComZ; pfam10815 405534003964 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 405534003965 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 405534003966 dimer interface [polypeptide binding]; other site 405534003967 active site 405534003968 CoA binding pocket [chemical binding]; other site 405534003969 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 405534003970 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 405534003971 dimer interface [polypeptide binding]; other site 405534003972 active site 405534003973 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 405534003974 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 405534003975 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 405534003976 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 405534003977 active site 405534003978 HIGH motif; other site 405534003979 dimer interface [polypeptide binding]; other site 405534003980 KMSKS motif; other site 405534003981 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 405534003982 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405534003983 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405534003984 peptide binding site [polypeptide binding]; other site 405534003985 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405534003986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534003987 dimer interface [polypeptide binding]; other site 405534003988 conserved gate region; other site 405534003989 putative PBP binding loops; other site 405534003990 ABC-ATPase subunit interface; other site 405534003991 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405534003992 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 405534003993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534003994 dimer interface [polypeptide binding]; other site 405534003995 conserved gate region; other site 405534003996 putative PBP binding loops; other site 405534003997 ABC-ATPase subunit interface; other site 405534003998 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 405534003999 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405534004000 Walker A/P-loop; other site 405534004001 ATP binding site [chemical binding]; other site 405534004002 Q-loop/lid; other site 405534004003 ABC transporter signature motif; other site 405534004004 Walker B; other site 405534004005 D-loop; other site 405534004006 H-loop/switch region; other site 405534004007 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405534004008 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 405534004009 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405534004010 Walker A/P-loop; other site 405534004011 ATP binding site [chemical binding]; other site 405534004012 Q-loop/lid; other site 405534004013 ABC transporter signature motif; other site 405534004014 Walker B; other site 405534004015 D-loop; other site 405534004016 H-loop/switch region; other site 405534004017 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405534004018 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 405534004019 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 405534004020 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405534004021 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405534004022 peptide binding site [polypeptide binding]; other site 405534004023 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 405534004024 ArsC family; Region: ArsC; pfam03960 405534004025 putative catalytic residues [active] 405534004026 thiol/disulfide switch; other site 405534004027 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 405534004028 adaptor protein; Provisional; Region: PRK02315 405534004029 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 405534004030 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 405534004031 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405534004032 putative active site [active] 405534004033 catalytic site [active] 405534004034 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 405534004035 putative active site [active] 405534004036 catalytic site [active] 405534004037 Competence protein CoiA-like family; Region: CoiA; cl11541 405534004038 oligoendopeptidase F; Region: pepF; TIGR00181 405534004039 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 405534004040 active site 405534004041 Zn binding site [ion binding]; other site 405534004042 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 405534004043 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 405534004044 catalytic residues [active] 405534004045 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 405534004046 apolar tunnel; other site 405534004047 heme binding site [chemical binding]; other site 405534004048 dimerization interface [polypeptide binding]; other site 405534004049 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 405534004050 putative active site [active] 405534004051 putative metal binding residues [ion binding]; other site 405534004052 signature motif; other site 405534004053 putative triphosphate binding site [ion binding]; other site 405534004054 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 405534004055 synthetase active site [active] 405534004056 NTP binding site [chemical binding]; other site 405534004057 metal binding site [ion binding]; metal-binding site 405534004058 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 405534004059 ATP-NAD kinase; Region: NAD_kinase; pfam01513 405534004060 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 405534004061 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 405534004062 active site 405534004063 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 405534004064 trimer interface [polypeptide binding]; other site 405534004065 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 405534004066 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 405534004067 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 405534004068 active site 405534004069 metal binding site [ion binding]; metal-binding site 405534004070 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 405534004071 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 405534004072 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 405534004073 active site 405534004074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534004075 S-adenosylmethionine binding site [chemical binding]; other site 405534004076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 405534004077 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 405534004078 putative metal binding site; other site 405534004079 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405534004080 binding surface 405534004081 TPR motif; other site 405534004082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 405534004083 binding surface 405534004084 TPR motif; other site 405534004085 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405534004086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534004087 S-adenosylmethionine binding site [chemical binding]; other site 405534004088 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 405534004089 catalytic residues [active] 405534004090 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 405534004091 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 405534004092 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405534004093 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 405534004094 active site 405534004095 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 405534004096 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 405534004097 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 405534004098 NAD binding site [chemical binding]; other site 405534004099 substrate binding site [chemical binding]; other site 405534004100 homodimer interface [polypeptide binding]; other site 405534004101 active site 405534004102 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 405534004103 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 405534004104 NADP binding site [chemical binding]; other site 405534004105 active site 405534004106 putative substrate binding site [chemical binding]; other site 405534004107 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 405534004108 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 405534004109 NAD binding site [chemical binding]; other site 405534004110 homotetramer interface [polypeptide binding]; other site 405534004111 homodimer interface [polypeptide binding]; other site 405534004112 substrate binding site [chemical binding]; other site 405534004113 active site 405534004114 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 405534004115 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 405534004116 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 405534004117 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 405534004118 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 405534004119 Part of AAA domain; Region: AAA_19; pfam13245 405534004120 Family description; Region: UvrD_C_2; pfam13538 405534004121 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 405534004122 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534004123 Coenzyme A binding pocket [chemical binding]; other site 405534004124 hypothetical protein; Provisional; Region: PRK13679 405534004125 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 405534004126 Putative esterase; Region: Esterase; pfam00756 405534004127 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 405534004128 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405534004129 EamA-like transporter family; Region: EamA; pfam00892 405534004130 EamA-like transporter family; Region: EamA; pfam00892 405534004131 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 405534004132 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 405534004133 Pectate lyase; Region: Pectate_lyase; pfam03211 405534004134 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 405534004135 Na binding site [ion binding]; other site 405534004136 anthranilate synthase component I; Provisional; Region: PRK13570 405534004137 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 405534004138 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 405534004139 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 405534004140 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 405534004141 glutamine binding [chemical binding]; other site 405534004142 catalytic triad [active] 405534004143 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 405534004144 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 405534004145 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 405534004146 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 405534004147 active site 405534004148 ribulose/triose binding site [chemical binding]; other site 405534004149 phosphate binding site [ion binding]; other site 405534004150 substrate (anthranilate) binding pocket [chemical binding]; other site 405534004151 product (indole) binding pocket [chemical binding]; other site 405534004152 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 405534004153 active site 405534004154 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 405534004155 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 405534004156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534004157 catalytic residue [active] 405534004158 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 405534004159 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 405534004160 substrate binding site [chemical binding]; other site 405534004161 active site 405534004162 catalytic residues [active] 405534004163 heterodimer interface [polypeptide binding]; other site 405534004164 Protein of unknown function (DUF4029); Region: DUF4029; pfam13221 405534004165 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 405534004166 L-lactate permease; Region: Lactate_perm; cl00701 405534004167 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 405534004168 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405534004169 catalytic residues [active] 405534004170 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 405534004171 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 405534004172 Double zinc ribbon; Region: DZR; pfam12773 405534004173 YARHG domain; Region: YARHG; pfam13308 405534004174 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405534004175 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 405534004176 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405534004177 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405534004178 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534004179 Coenzyme A binding pocket [chemical binding]; other site 405534004180 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 405534004181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534004182 S-adenosylmethionine binding site [chemical binding]; other site 405534004183 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 405534004184 NADPH bind site [chemical binding]; other site 405534004185 putative FMN binding site [chemical binding]; other site 405534004186 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 405534004187 putative FMN binding site [chemical binding]; other site 405534004188 NADPH bind site [chemical binding]; other site 405534004189 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 405534004190 YcaO-like family; Region: YcaO; pfam02624 405534004191 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 405534004192 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 405534004193 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 405534004194 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 405534004195 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405534004196 E3 interaction surface; other site 405534004197 lipoyl attachment site [posttranslational modification]; other site 405534004198 e3 binding domain; Region: E3_binding; pfam02817 405534004199 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 405534004200 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 405534004201 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 405534004202 TPP-binding site [chemical binding]; other site 405534004203 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 405534004204 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534004205 salt bridge; other site 405534004206 non-specific DNA binding site [nucleotide binding]; other site 405534004207 sequence-specific DNA binding site [nucleotide binding]; other site 405534004208 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 405534004209 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 405534004210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534004211 S-adenosylmethionine binding site [chemical binding]; other site 405534004212 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 405534004213 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405534004214 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 405534004215 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 405534004216 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405534004217 Catalytic site [active] 405534004218 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 405534004219 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 405534004220 Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389 405534004221 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405534004222 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534004223 non-specific DNA binding site [nucleotide binding]; other site 405534004224 salt bridge; other site 405534004225 sequence-specific DNA binding site [nucleotide binding]; other site 405534004226 Anti-repressor SinI; Region: SinI; pfam08671 405534004227 Anti-repressor SinI; Region: SinI; pfam08671 405534004228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 405534004229 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 405534004230 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 405534004231 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 405534004232 NAD(P) binding site [chemical binding]; other site 405534004233 catalytic residues [active] 405534004234 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 405534004235 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 405534004236 Walker A/P-loop; other site 405534004237 ATP binding site [chemical binding]; other site 405534004238 Q-loop/lid; other site 405534004239 ABC transporter signature motif; other site 405534004240 Walker B; other site 405534004241 D-loop; other site 405534004242 H-loop/switch region; other site 405534004243 TOBE domain; Region: TOBE_2; pfam08402 405534004244 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 405534004245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534004246 dimer interface [polypeptide binding]; other site 405534004247 conserved gate region; other site 405534004248 putative PBP binding loops; other site 405534004249 ABC-ATPase subunit interface; other site 405534004250 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 405534004251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534004252 dimer interface [polypeptide binding]; other site 405534004253 conserved gate region; other site 405534004254 putative PBP binding loops; other site 405534004255 ABC-ATPase subunit interface; other site 405534004256 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 405534004257 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 405534004258 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 405534004259 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405534004260 active site 405534004261 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 405534004262 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 405534004263 ABC-2 type transporter; Region: ABC2_membrane; cl17235 405534004264 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 405534004265 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 405534004266 active site 405534004267 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 405534004268 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 405534004269 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 405534004270 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 405534004271 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 405534004272 Cysteine-rich domain; Region: CCG; pfam02754 405534004273 Cysteine-rich domain; Region: CCG; pfam02754 405534004274 FAD binding domain; Region: FAD_binding_4; pfam01565 405534004275 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 405534004276 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 405534004277 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 405534004278 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 405534004279 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 405534004280 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 405534004281 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534004282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534004283 active site 405534004284 phosphorylation site [posttranslational modification] 405534004285 intermolecular recognition site; other site 405534004286 dimerization interface [polypeptide binding]; other site 405534004287 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534004288 DNA binding site [nucleotide binding] 405534004289 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 405534004290 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534004291 dimerization interface [polypeptide binding]; other site 405534004292 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534004293 dimer interface [polypeptide binding]; other site 405534004294 phosphorylation site [posttranslational modification] 405534004295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534004296 ATP binding site [chemical binding]; other site 405534004297 Mg2+ binding site [ion binding]; other site 405534004298 G-X-G motif; other site 405534004299 Transcriptional regulators [Transcription]; Region: FadR; COG2186 405534004300 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405534004301 DNA-binding site [nucleotide binding]; DNA binding site 405534004302 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 405534004303 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 405534004304 Cysteine-rich domain; Region: CCG; pfam02754 405534004305 Cysteine-rich domain; Region: CCG; pfam02754 405534004306 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 405534004307 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 405534004308 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 405534004309 Uncharacterized conserved protein [Function unknown]; Region: COG1556 405534004310 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 405534004311 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 405534004312 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 405534004313 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 405534004314 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 405534004315 yybP-ykoY leader 405534004316 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 405534004317 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 405534004318 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405534004319 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 405534004320 dimer interaction site [polypeptide binding]; other site 405534004321 substrate-binding tunnel; other site 405534004322 active site 405534004323 catalytic site [active] 405534004324 substrate binding site [chemical binding]; other site 405534004325 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 405534004326 poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719 405534004327 Predicted transcriptional regulators [Transcription]; Region: COG1695 405534004328 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 405534004329 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 405534004330 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 405534004331 NAD(P) binding site [chemical binding]; other site 405534004332 homotetramer interface [polypeptide binding]; other site 405534004333 homodimer interface [polypeptide binding]; other site 405534004334 active site 405534004335 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 405534004336 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 405534004337 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 405534004338 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 405534004339 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 405534004340 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 405534004341 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 405534004342 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 405534004343 putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261 405534004344 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 405534004345 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 405534004346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534004347 dimer interface [polypeptide binding]; other site 405534004348 conserved gate region; other site 405534004349 putative PBP binding loops; other site 405534004350 ABC-ATPase subunit interface; other site 405534004351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534004352 dimer interface [polypeptide binding]; other site 405534004353 conserved gate region; other site 405534004354 putative PBP binding loops; other site 405534004355 ABC-ATPase subunit interface; other site 405534004356 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 405534004357 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534004358 motif II; other site 405534004359 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 405534004360 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405534004361 catalytic residue [active] 405534004362 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 405534004363 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 405534004364 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 405534004365 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405534004366 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405534004367 heme-binding site [chemical binding]; other site 405534004368 Leucine rich repeat; Region: LRR_8; pfam13855 405534004369 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 405534004370 Leucine-rich repeats; other site 405534004371 Leucine rich repeat; Region: LRR_8; pfam13855 405534004372 Substrate binding site [chemical binding]; other site 405534004373 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405534004374 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405534004375 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405534004376 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405534004377 S-layer homology domain; Region: SLH; pfam00395 405534004378 S-layer homology domain; Region: SLH; pfam00395 405534004379 S-layer homology domain; Region: SLH; pfam00395 405534004380 hypothetical protein; Validated; Region: PRK06755 405534004381 intersubunit interface [polypeptide binding]; other site 405534004382 active site 405534004383 Zn2+ binding site [ion binding]; other site 405534004384 FOG: CBS domain [General function prediction only]; Region: COG0517 405534004385 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 405534004386 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 405534004387 NodB motif; other site 405534004388 putative active site [active] 405534004389 putative catalytic site [active] 405534004390 Zn binding site [ion binding]; other site 405534004391 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 405534004392 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 405534004393 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534004394 dimer interface [polypeptide binding]; other site 405534004395 phosphorylation site [posttranslational modification] 405534004396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534004397 ATP binding site [chemical binding]; other site 405534004398 Mg2+ binding site [ion binding]; other site 405534004399 G-X-G motif; other site 405534004400 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405534004401 MarR family; Region: MarR; pfam01047 405534004402 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 405534004403 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 405534004404 active site 405534004405 Zn binding site [ion binding]; other site 405534004406 DinB superfamily; Region: DinB_2; pfam12867 405534004407 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 405534004408 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534004409 dimer interface [polypeptide binding]; other site 405534004410 phosphorylation site [posttranslational modification] 405534004411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534004412 ATP binding site [chemical binding]; other site 405534004413 Mg2+ binding site [ion binding]; other site 405534004414 G-X-G motif; other site 405534004415 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 405534004416 Ligand Binding Site [chemical binding]; other site 405534004417 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 405534004418 active site 405534004419 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 405534004420 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 405534004421 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 405534004422 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 405534004423 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534004424 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405534004425 Coenzyme A binding pocket [chemical binding]; other site 405534004426 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 405534004427 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 405534004428 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 405534004429 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 405534004430 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 405534004431 dimer interface [polypeptide binding]; other site 405534004432 putative radical transfer pathway; other site 405534004433 diiron center [ion binding]; other site 405534004434 tyrosyl radical; other site 405534004435 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 405534004436 Predicted transcriptional regulators [Transcription]; Region: COG1725 405534004437 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405534004438 DNA-binding site [nucleotide binding]; DNA binding site 405534004439 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405534004440 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405534004441 Walker A/P-loop; other site 405534004442 ATP binding site [chemical binding]; other site 405534004443 Q-loop/lid; other site 405534004444 ABC transporter signature motif; other site 405534004445 Walker B; other site 405534004446 D-loop; other site 405534004447 H-loop/switch region; other site 405534004448 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405534004449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534004450 Walker A/P-loop; other site 405534004451 ATP binding site [chemical binding]; other site 405534004452 Q-loop/lid; other site 405534004453 ABC transporter signature motif; other site 405534004454 Walker B; other site 405534004455 D-loop; other site 405534004456 H-loop/switch region; other site 405534004457 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 405534004458 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405534004459 CAAX protease self-immunity; Region: Abi; pfam02517 405534004460 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 405534004461 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 405534004462 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 405534004463 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534004464 putative DNA binding site [nucleotide binding]; other site 405534004465 putative Zn2+ binding site [ion binding]; other site 405534004466 AsnC family; Region: AsnC_trans_reg; pfam01037 405534004467 Uncharacterized conserved protein [Function unknown]; Region: COG2128 405534004468 Isochorismatase family; Region: Isochorismatase; pfam00857 405534004469 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 405534004470 catalytic triad [active] 405534004471 conserved cis-peptide bond; other site 405534004472 SseB protein; Region: SseB; cl06279 405534004473 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 405534004474 dimer interface [polypeptide binding]; other site 405534004475 catalytic triad [active] 405534004476 Nitronate monooxygenase; Region: NMO; pfam03060 405534004477 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 405534004478 FMN binding site [chemical binding]; other site 405534004479 substrate binding site [chemical binding]; other site 405534004480 putative catalytic residue [active] 405534004481 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 405534004482 DltD N-terminal region; Region: DltD_N; pfam04915 405534004483 DltD central region; Region: DltD_M; pfam04918 405534004484 DltD C-terminal region; Region: DltD_C; pfam04914 405534004485 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 405534004486 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 405534004487 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 405534004488 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 405534004489 acyl-activating enzyme (AAE) consensus motif; other site 405534004490 AMP binding site [chemical binding]; other site 405534004491 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 405534004492 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405534004493 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 405534004494 metal binding site [ion binding]; metal-binding site 405534004495 dimer interface [polypeptide binding]; other site 405534004496 flavodoxin; Provisional; Region: PRK06756 405534004497 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 405534004498 Phosphotransferase enzyme family; Region: APH; pfam01636 405534004499 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405534004500 active site 405534004501 substrate binding site [chemical binding]; other site 405534004502 ATP binding site [chemical binding]; other site 405534004503 multidrug efflux protein; Reviewed; Region: PRK01766 405534004504 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 405534004505 cation binding site [ion binding]; other site 405534004506 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 405534004507 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405534004508 catalytic residues [active] 405534004509 Regulatory protein YrvL; Region: YrvL; pfam14184 405534004510 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405534004511 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 405534004512 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405534004513 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 405534004514 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 405534004515 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 405534004516 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 405534004517 hypothetical protein; Provisional; Region: PRK03094 405534004518 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 405534004519 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 405534004520 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 405534004521 homodimer interface [polypeptide binding]; other site 405534004522 substrate-cofactor binding pocket; other site 405534004523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534004524 catalytic residue [active] 405534004525 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 405534004526 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 405534004527 PYR/PP interface [polypeptide binding]; other site 405534004528 dimer interface [polypeptide binding]; other site 405534004529 TPP binding site [chemical binding]; other site 405534004530 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405534004531 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 405534004532 TPP-binding site [chemical binding]; other site 405534004533 dimer interface [polypeptide binding]; other site 405534004534 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 405534004535 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 405534004536 putative valine binding site [chemical binding]; other site 405534004537 dimer interface [polypeptide binding]; other site 405534004538 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 405534004539 ketol-acid reductoisomerase; Provisional; Region: PRK05479 405534004540 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 405534004541 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 405534004542 2-isopropylmalate synthase; Validated; Region: PRK00915 405534004543 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 405534004544 active site 405534004545 catalytic residues [active] 405534004546 metal binding site [ion binding]; metal-binding site 405534004547 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 405534004548 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 405534004549 tartrate dehydrogenase; Region: TTC; TIGR02089 405534004550 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 405534004551 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 405534004552 substrate binding site [chemical binding]; other site 405534004553 ligand binding site [chemical binding]; other site 405534004554 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 405534004555 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 405534004556 substrate binding site [chemical binding]; other site 405534004557 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 405534004558 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 405534004559 dimer interface [polypeptide binding]; other site 405534004560 motif 1; other site 405534004561 active site 405534004562 motif 2; other site 405534004563 motif 3; other site 405534004564 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 405534004565 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 405534004566 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 405534004567 histidinol dehydrogenase; Region: hisD; TIGR00069 405534004568 NAD binding site [chemical binding]; other site 405534004569 dimerization interface [polypeptide binding]; other site 405534004570 product binding site; other site 405534004571 substrate binding site [chemical binding]; other site 405534004572 zinc binding site [ion binding]; other site 405534004573 catalytic residues [active] 405534004574 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 405534004575 putative active site pocket [active] 405534004576 4-fold oligomerization interface [polypeptide binding]; other site 405534004577 metal binding residues [ion binding]; metal-binding site 405534004578 3-fold/trimer interface [polypeptide binding]; other site 405534004579 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 405534004580 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 405534004581 putative active site [active] 405534004582 oxyanion strand; other site 405534004583 catalytic triad [active] 405534004584 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 405534004585 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 405534004586 catalytic residues [active] 405534004587 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 405534004588 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 405534004589 substrate binding site [chemical binding]; other site 405534004590 glutamase interaction surface [polypeptide binding]; other site 405534004591 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 405534004592 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 405534004593 metal binding site [ion binding]; metal-binding site 405534004594 histidinol-phosphatase; Validated; Region: PRK06740 405534004595 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 405534004596 dimer interface [polypeptide binding]; other site 405534004597 active site 405534004598 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 405534004599 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 405534004600 putative ligand binding site [chemical binding]; other site 405534004601 putative NAD binding site [chemical binding]; other site 405534004602 catalytic site [active] 405534004603 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 405534004604 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 405534004605 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 405534004606 Sulfatase; Region: Sulfatase; pfam00884 405534004607 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 405534004608 Lysine riboswitch 405534004609 diaminopimelate decarboxylase; Region: lysA; TIGR01048 405534004610 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 405534004611 active site 405534004612 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405534004613 substrate binding site [chemical binding]; other site 405534004614 catalytic residues [active] 405534004615 dimer interface [polypeptide binding]; other site 405534004616 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 405534004617 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 405534004618 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 405534004619 Active Sites [active] 405534004620 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 405534004621 ATP-sulfurylase; Region: ATPS; cd00517 405534004622 active site 405534004623 HXXH motif; other site 405534004624 flexible loop; other site 405534004625 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 405534004626 AAA domain; Region: AAA_18; pfam13238 405534004627 ligand-binding site [chemical binding]; other site 405534004628 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 405534004629 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 405534004630 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 405534004631 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 405534004632 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 405534004633 diphthine synthase; Region: dph5; TIGR00522 405534004634 active site 405534004635 SAM binding site [chemical binding]; other site 405534004636 homodimer interface [polypeptide binding]; other site 405534004637 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 405534004638 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 405534004639 putative active site [active] 405534004640 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 405534004641 putative active site [active] 405534004642 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 405534004643 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 405534004644 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 405534004645 Na2 binding site [ion binding]; other site 405534004646 putative substrate binding site 1 [chemical binding]; other site 405534004647 Na binding site 1 [ion binding]; other site 405534004648 putative substrate binding site 2 [chemical binding]; other site 405534004649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 405534004650 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405534004651 Peptidase family M23; Region: Peptidase_M23; pfam01551 405534004652 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405534004653 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 405534004654 Protein of unknown function (DUF402); Region: DUF402; cl00979 405534004655 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 405534004656 Vpu protein; Region: Vpu; pfam00558 405534004657 PspA/IM30 family; Region: PspA_IM30; pfam04012 405534004658 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 405534004659 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405534004660 Histidine kinase; Region: HisKA_3; pfam07730 405534004661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534004662 ATP binding site [chemical binding]; other site 405534004663 Mg2+ binding site [ion binding]; other site 405534004664 G-X-G motif; other site 405534004665 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405534004666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534004667 active site 405534004668 phosphorylation site [posttranslational modification] 405534004669 intermolecular recognition site; other site 405534004670 dimerization interface [polypeptide binding]; other site 405534004671 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405534004672 DNA binding residues [nucleotide binding] 405534004673 dimerization interface [polypeptide binding]; other site 405534004674 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405534004675 E3 interaction surface; other site 405534004676 lipoyl attachment site [posttranslational modification]; other site 405534004677 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405534004678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534004679 S-adenosylmethionine binding site [chemical binding]; other site 405534004680 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 405534004681 Peptidase family M50; Region: Peptidase_M50; pfam02163 405534004682 active site 405534004683 putative substrate binding region [chemical binding]; other site 405534004684 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 405534004685 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 405534004686 heme-binding site [chemical binding]; other site 405534004687 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 405534004688 FAD binding pocket [chemical binding]; other site 405534004689 FAD binding motif [chemical binding]; other site 405534004690 phosphate binding motif [ion binding]; other site 405534004691 beta-alpha-beta structure motif; other site 405534004692 NAD binding pocket [chemical binding]; other site 405534004693 Heme binding pocket [chemical binding]; other site 405534004694 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 405534004695 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405534004696 ligand binding site [chemical binding]; other site 405534004697 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 405534004698 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405534004699 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 405534004700 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 405534004701 Transglycosylase; Region: Transgly; pfam00912 405534004702 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 405534004703 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405534004704 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 405534004705 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 405534004706 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405534004707 putative active site [active] 405534004708 heme pocket [chemical binding]; other site 405534004709 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534004710 dimer interface [polypeptide binding]; other site 405534004711 phosphorylation site [posttranslational modification] 405534004712 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534004713 ATP binding site [chemical binding]; other site 405534004714 Mg2+ binding site [ion binding]; other site 405534004715 G-X-G motif; other site 405534004716 Protein of unknown function DUF72; Region: DUF72; pfam01904 405534004717 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 405534004718 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405534004719 active site 405534004720 DNA binding site [nucleotide binding] 405534004721 Int/Topo IB signature motif; other site 405534004722 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534004723 dimerization interface [polypeptide binding]; other site 405534004724 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534004725 dimer interface [polypeptide binding]; other site 405534004726 phosphorylation site [posttranslational modification] 405534004727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534004728 ATP binding site [chemical binding]; other site 405534004729 Mg2+ binding site [ion binding]; other site 405534004730 G-X-G motif; other site 405534004731 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 405534004732 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 405534004733 Predicted integral membrane protein [Function unknown]; Region: COG0392 405534004734 Uncharacterized conserved protein [Function unknown]; Region: COG2898 405534004735 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 405534004736 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 405534004737 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 405534004738 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 405534004739 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 405534004740 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405534004741 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 405534004742 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 405534004743 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 405534004744 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 405534004745 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405534004746 RNA binding surface [nucleotide binding]; other site 405534004747 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 405534004748 active site 405534004749 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 405534004750 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 405534004751 catalytic residues [active] 405534004752 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 405534004753 ResB-like family; Region: ResB; pfam05140 405534004754 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 405534004755 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 405534004756 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534004757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534004758 active site 405534004759 phosphorylation site [posttranslational modification] 405534004760 intermolecular recognition site; other site 405534004761 dimerization interface [polypeptide binding]; other site 405534004762 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534004763 DNA binding site [nucleotide binding] 405534004764 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 405534004765 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534004766 dimerization interface [polypeptide binding]; other site 405534004767 PAS domain; Region: PAS; smart00091 405534004768 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534004769 dimer interface [polypeptide binding]; other site 405534004770 phosphorylation site [posttranslational modification] 405534004771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534004772 ATP binding site [chemical binding]; other site 405534004773 Mg2+ binding site [ion binding]; other site 405534004774 G-X-G motif; other site 405534004775 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 405534004776 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405534004777 Peptidase family M23; Region: Peptidase_M23; pfam01551 405534004778 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405534004779 Predicted membrane protein [Function unknown]; Region: COG3601 405534004780 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 405534004781 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 405534004782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 405534004783 DEAD-like helicases superfamily; Region: DEXDc; smart00487 405534004784 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405534004785 ATP binding site [chemical binding]; other site 405534004786 putative Mg++ binding site [ion binding]; other site 405534004787 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405534004788 nucleotide binding region [chemical binding]; other site 405534004789 ATP-binding site [chemical binding]; other site 405534004790 CAAX protease self-immunity; Region: Abi; pfam02517 405534004791 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405534004792 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 405534004793 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405534004794 putative active site [active] 405534004795 putative metal binding site [ion binding]; other site 405534004796 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405534004797 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 405534004798 DNA binding residues [nucleotide binding] 405534004799 B12 binding domain; Region: B12-binding_2; pfam02607 405534004800 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 405534004801 adaptor protein; Provisional; Region: PRK02899 405534004802 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 405534004803 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 405534004804 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 405534004805 NAD(P) binding site [chemical binding]; other site 405534004806 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 405534004807 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405534004808 amidase catalytic site [active] 405534004809 Zn binding residues [ion binding]; other site 405534004810 substrate binding site [chemical binding]; other site 405534004811 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 405534004812 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 405534004813 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405534004814 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 405534004815 active site 405534004816 homodimer interface [polypeptide binding]; other site 405534004817 homotetramer interface [polypeptide binding]; other site 405534004818 cytidylate kinase; Provisional; Region: cmk; PRK00023 405534004819 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 405534004820 CMP-binding site; other site 405534004821 The sites determining sugar specificity; other site 405534004822 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 405534004823 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 405534004824 RNA binding site [nucleotide binding]; other site 405534004825 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 405534004826 RNA binding site [nucleotide binding]; other site 405534004827 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 405534004828 RNA binding site [nucleotide binding]; other site 405534004829 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 405534004830 RNA binding site [nucleotide binding]; other site 405534004831 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 405534004832 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 405534004833 homotetramer interface [polypeptide binding]; other site 405534004834 FMN binding site [chemical binding]; other site 405534004835 homodimer contacts [polypeptide binding]; other site 405534004836 putative active site [active] 405534004837 putative substrate binding site [chemical binding]; other site 405534004838 YpzI-like protein; Region: YpzI; pfam14140 405534004839 YIEGIA protein; Region: YIEGIA; pfam14045 405534004840 GTP-binding protein Der; Reviewed; Region: PRK00093 405534004841 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 405534004842 G1 box; other site 405534004843 GTP/Mg2+ binding site [chemical binding]; other site 405534004844 Switch I region; other site 405534004845 G2 box; other site 405534004846 Switch II region; other site 405534004847 G3 box; other site 405534004848 G4 box; other site 405534004849 G5 box; other site 405534004850 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 405534004851 G1 box; other site 405534004852 GTP/Mg2+ binding site [chemical binding]; other site 405534004853 Switch I region; other site 405534004854 G2 box; other site 405534004855 G3 box; other site 405534004856 Switch II region; other site 405534004857 G4 box; other site 405534004858 G5 box; other site 405534004859 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 405534004860 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 405534004861 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 405534004862 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 405534004863 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 405534004864 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 405534004865 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 405534004866 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 405534004867 IHF dimer interface [polypeptide binding]; other site 405534004868 IHF - DNA interface [nucleotide binding]; other site 405534004869 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 405534004870 homodecamer interface [polypeptide binding]; other site 405534004871 GTP cyclohydrolase I; Provisional; Region: PLN03044 405534004872 active site 405534004873 putative catalytic site residues [active] 405534004874 zinc binding site [ion binding]; other site 405534004875 GTP-CH-I/GFRP interaction surface; other site 405534004876 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 405534004877 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 405534004878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534004879 S-adenosylmethionine binding site [chemical binding]; other site 405534004880 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 405534004881 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 405534004882 substrate binding pocket [chemical binding]; other site 405534004883 chain length determination region; other site 405534004884 substrate-Mg2+ binding site; other site 405534004885 catalytic residues [active] 405534004886 aspartate-rich region 1; other site 405534004887 active site lid residues [active] 405534004888 aspartate-rich region 2; other site 405534004889 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 405534004890 active site 405534004891 multimer interface [polypeptide binding]; other site 405534004892 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 405534004893 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 405534004894 Tetramer interface [polypeptide binding]; other site 405534004895 active site 405534004896 FMN-binding site [chemical binding]; other site 405534004897 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 405534004898 active site 405534004899 dimer interface [polypeptide binding]; other site 405534004900 metal binding site [ion binding]; metal-binding site 405534004901 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 405534004902 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405534004903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534004904 homodimer interface [polypeptide binding]; other site 405534004905 catalytic residue [active] 405534004906 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405534004907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405534004908 binding surface 405534004909 TPR motif; other site 405534004910 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 405534004911 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405534004912 binding surface 405534004913 TPR motif; other site 405534004914 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405534004915 TPR repeat; Region: TPR_11; pfam13414 405534004916 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405534004917 binding surface 405534004918 TPR motif; other site 405534004919 hypothetical protein; Provisional; Region: PRK03636 405534004920 UPF0302 domain; Region: UPF0302; pfam08864 405534004921 IDEAL domain; Region: IDEAL; pfam08858 405534004922 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 405534004923 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 405534004924 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 405534004925 iron-sulfur cluster [ion binding]; other site 405534004926 [2Fe-2S] cluster binding site [ion binding]; other site 405534004927 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 405534004928 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 405534004929 interchain domain interface [polypeptide binding]; other site 405534004930 intrachain domain interface; other site 405534004931 heme bH binding site [chemical binding]; other site 405534004932 Qi binding site; other site 405534004933 heme bL binding site [chemical binding]; other site 405534004934 Qo binding site; other site 405534004935 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 405534004936 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 405534004937 interchain domain interface [polypeptide binding]; other site 405534004938 intrachain domain interface; other site 405534004939 Qi binding site; other site 405534004940 Qo binding site; other site 405534004941 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 405534004942 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 405534004943 Homeodomain-like domain; Region: HTH_23; pfam13384 405534004944 putative transposase OrfB; Reviewed; Region: PHA02517 405534004945 HTH-like domain; Region: HTH_21; pfam13276 405534004946 Integrase core domain; Region: rve; pfam00665 405534004947 Integrase core domain; Region: rve_2; pfam13333 405534004948 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 405534004949 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 405534004950 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 405534004951 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 405534004952 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 405534004953 active site 405534004954 Fe-S cluster binding site [ion binding]; other site 405534004955 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405534004956 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405534004957 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405534004958 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405534004959 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 405534004960 homodimer interface [polypeptide binding]; other site 405534004961 metal binding site [ion binding]; metal-binding site 405534004962 dihydrodipicolinate reductase; Provisional; Region: PRK00048 405534004963 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 405534004964 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 405534004965 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 405534004966 active site 405534004967 dimer interfaces [polypeptide binding]; other site 405534004968 catalytic residues [active] 405534004969 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 405534004970 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 405534004971 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 405534004972 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 405534004973 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 405534004974 active site 405534004975 NTP binding site [chemical binding]; other site 405534004976 metal binding triad [ion binding]; metal-binding site 405534004977 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 405534004978 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 405534004979 Biotin operon repressor [Transcription]; Region: BirA; COG1654 405534004980 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 405534004981 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 405534004982 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 405534004983 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 405534004984 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 405534004985 oligomerization interface [polypeptide binding]; other site 405534004986 active site 405534004987 metal binding site [ion binding]; metal-binding site 405534004988 pantoate--beta-alanine ligase; Region: panC; TIGR00018 405534004989 Pantoate-beta-alanine ligase; Region: PanC; cd00560 405534004990 active site 405534004991 ATP-binding site [chemical binding]; other site 405534004992 pantoate-binding site; other site 405534004993 HXXH motif; other site 405534004994 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 405534004995 tetramerization interface [polypeptide binding]; other site 405534004996 active site 405534004997 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 405534004998 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 405534004999 active site 405534005000 catalytic site [active] 405534005001 substrate binding site [chemical binding]; other site 405534005002 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 405534005003 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 405534005004 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 405534005005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 405534005006 aspartate aminotransferase; Provisional; Region: PRK05764 405534005007 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405534005008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534005009 homodimer interface [polypeptide binding]; other site 405534005010 catalytic residue [active] 405534005011 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 405534005012 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 405534005013 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 405534005014 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 405534005015 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 405534005016 minor groove reading motif; other site 405534005017 helix-hairpin-helix signature motif; other site 405534005018 substrate binding pocket [chemical binding]; other site 405534005019 active site 405534005020 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 405534005021 Transglycosylase; Region: Transgly; pfam00912 405534005022 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 405534005023 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 405534005024 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405534005025 Interdomain contacts; other site 405534005026 Cytokine receptor motif; other site 405534005027 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 405534005028 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 405534005029 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 405534005030 YppF-like protein; Region: YppF; pfam14178 405534005031 YppG-like protein; Region: YppG; pfam14179 405534005032 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 405534005033 hypothetical protein; Provisional; Region: PRK13660 405534005034 cell division protein GpsB; Provisional; Region: PRK14127 405534005035 DivIVA domain; Region: DivI1A_domain; TIGR03544 405534005036 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 405534005037 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 405534005038 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 405534005039 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 405534005040 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 405534005041 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 405534005042 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 405534005043 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 405534005044 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 405534005045 active site 405534005046 Zn binding site [ion binding]; other site 405534005047 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405534005048 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405534005049 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 405534005050 active site 405534005051 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405534005052 active site 405534005053 xanthine permease; Region: pbuX; TIGR03173 405534005054 Predicted membrane protein [Function unknown]; Region: COG2311 405534005055 Protein of unknown function (DUF418); Region: DUF418; cl12135 405534005056 Protein of unknown function (DUF418); Region: DUF418; pfam04235 405534005057 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 405534005058 Dynamin family; Region: Dynamin_N; pfam00350 405534005059 G1 box; other site 405534005060 GTP/Mg2+ binding site [chemical binding]; other site 405534005061 G2 box; other site 405534005062 Switch I region; other site 405534005063 G3 box; other site 405534005064 Switch II region; other site 405534005065 G4 box; other site 405534005066 G5 box; other site 405534005067 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 405534005068 Dynamin family; Region: Dynamin_N; pfam00350 405534005069 G1 box; other site 405534005070 GTP/Mg2+ binding site [chemical binding]; other site 405534005071 G2 box; other site 405534005072 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 405534005073 G3 box; other site 405534005074 Switch II region; other site 405534005075 GTP/Mg2+ binding site [chemical binding]; other site 405534005076 G4 box; other site 405534005077 G5 box; other site 405534005078 Protein of unknown function (DUF3931); Region: DUF3931; pfam13082 405534005079 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534005080 Coenzyme A binding pocket [chemical binding]; other site 405534005081 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 405534005082 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 405534005083 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 405534005084 active site residue [active] 405534005085 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 405534005086 active site residue [active] 405534005087 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 405534005088 Predicted membrane protein [Function unknown]; Region: COG3766 405534005089 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 405534005090 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 405534005091 ykoK leader 405534005092 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 405534005093 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405534005094 5'-3' exonuclease; Region: 53EXOc; smart00475 405534005095 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 405534005096 active site 405534005097 metal binding site 1 [ion binding]; metal-binding site 405534005098 putative 5' ssDNA interaction site; other site 405534005099 metal binding site 3; metal-binding site 405534005100 metal binding site 2 [ion binding]; metal-binding site 405534005101 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 405534005102 putative DNA binding site [nucleotide binding]; other site 405534005103 putative metal binding site [ion binding]; other site 405534005104 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 405534005105 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005106 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005107 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005108 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005109 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005110 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005111 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005112 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005113 Domain of unknown function DUF11; Region: DUF11; cl17728 405534005114 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005115 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005116 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005117 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005118 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005119 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005120 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005121 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005122 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005123 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005124 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005125 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005126 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005127 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005128 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005129 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005130 Domain of unknown function DUF11; Region: DUF11; cl17728 405534005131 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005132 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534005133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534005134 Coenzyme A binding pocket [chemical binding]; other site 405534005135 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 405534005136 Isochorismatase family; Region: Isochorismatase; pfam00857 405534005137 catalytic triad [active] 405534005138 conserved cis-peptide bond; other site 405534005139 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405534005140 EamA-like transporter family; Region: EamA; pfam00892 405534005141 EamA-like transporter family; Region: EamA; pfam00892 405534005142 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 405534005143 RNA/DNA hybrid binding site [nucleotide binding]; other site 405534005144 active site 405534005145 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 405534005146 active site 405534005147 catalytic residues [active] 405534005148 QueT transporter; Region: QueT; pfam06177 405534005149 hypothetical protein; Validated; Region: PRK07708 405534005150 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 405534005151 RNA/DNA hybrid binding site [nucleotide binding]; other site 405534005152 active site 405534005153 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 405534005154 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 405534005155 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405534005156 DNA-binding site [nucleotide binding]; DNA binding site 405534005157 RNA-binding motif; other site 405534005158 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 405534005159 LysE type translocator; Region: LysE; pfam01810 405534005160 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 405534005161 Protein of unknown function, DUF485; Region: DUF485; pfam04341 405534005162 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 405534005163 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 405534005164 Na binding site [ion binding]; other site 405534005165 aminotransferase; Validated; Region: PRK07678 405534005166 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405534005167 inhibitor-cofactor binding pocket; inhibition site 405534005168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534005169 catalytic residue [active] 405534005170 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 405534005171 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 405534005172 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 405534005173 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 405534005174 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405534005175 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 405534005176 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405534005177 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 405534005178 DNA binding residues [nucleotide binding] 405534005179 drug binding residues [chemical binding]; other site 405534005180 dimer interface [polypeptide binding]; other site 405534005181 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 405534005182 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 405534005183 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 405534005184 putative transposase OrfB; Reviewed; Region: PHA02517 405534005185 HTH-like domain; Region: HTH_21; pfam13276 405534005186 Integrase core domain; Region: rve; pfam00665 405534005187 Integrase core domain; Region: rve_2; pfam13333 405534005188 Homeodomain-like domain; Region: HTH_23; pfam13384 405534005189 Predicted membrane protein [Function unknown]; Region: COG2323 405534005190 Uncharacterized conserved protein [Function unknown]; Region: COG1434 405534005191 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 405534005192 putative active site [active] 405534005193 Tic20-like protein; Region: Tic20; pfam09685 405534005194 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 405534005195 dimer interface [polypeptide binding]; other site 405534005196 FMN binding site [chemical binding]; other site 405534005197 NADPH bind site [chemical binding]; other site 405534005198 DJ-1 family protein; Region: not_thiJ; TIGR01383 405534005199 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 405534005200 conserved cys residue [active] 405534005201 RNA polymerase factor sigma-70; Validated; Region: PRK06811 405534005202 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405534005203 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405534005204 DNA binding residues [nucleotide binding] 405534005205 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405534005206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534005207 H+ Antiporter protein; Region: 2A0121; TIGR00900 405534005208 putative substrate translocation pore; other site 405534005209 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534005210 dimerization interface [polypeptide binding]; other site 405534005211 putative DNA binding site [nucleotide binding]; other site 405534005212 putative Zn2+ binding site [ion binding]; other site 405534005213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534005214 H+ Antiporter protein; Region: 2A0121; TIGR00900 405534005215 putative substrate translocation pore; other site 405534005216 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405534005217 active site 405534005218 metal binding site [ion binding]; metal-binding site 405534005219 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534005220 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 405534005221 bacterial Hfq-like; Region: Hfq; cd01716 405534005222 hexamer interface [polypeptide binding]; other site 405534005223 Sm1 motif; other site 405534005224 RNA binding site [nucleotide binding]; other site 405534005225 Sm2 motif; other site 405534005226 HD domain; Region: HD_3; pfam13023 405534005227 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 405534005228 flagellar motor protein MotP; Reviewed; Region: PRK06743 405534005229 flagellar motor protein MotS; Reviewed; Region: PRK06742 405534005230 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 405534005231 ligand binding site [chemical binding]; other site 405534005232 Response regulator receiver domain; Region: Response_reg; pfam00072 405534005233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534005234 active site 405534005235 phosphorylation site [posttranslational modification] 405534005236 intermolecular recognition site; other site 405534005237 dimerization interface [polypeptide binding]; other site 405534005238 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 405534005239 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 405534005240 putative binding surface; other site 405534005241 active site 405534005242 P2 response regulator binding domain; Region: P2; pfam07194 405534005243 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 405534005244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534005245 ATP binding site [chemical binding]; other site 405534005246 Mg2+ binding site [ion binding]; other site 405534005247 G-X-G motif; other site 405534005248 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 405534005249 flagellar motor switch protein; Reviewed; Region: PRK06782 405534005250 CheC-like family; Region: CheC; pfam04509 405534005251 CheC-like family; Region: CheC; pfam04509 405534005252 CheC-like family; Region: CheC; pfam04509 405534005253 CheC-like family; Region: CheC; pfam04509 405534005254 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 405534005255 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 405534005256 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 405534005257 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 405534005258 Protein of unknown function (DUF327); Region: DUF327; pfam03885 405534005259 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 405534005260 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 405534005261 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 405534005262 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 405534005263 flagellar capping protein; Validated; Region: fliD; PRK06798 405534005264 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 405534005265 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 405534005266 Flagellar protein FliS; Region: FliS; cl00654 405534005267 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 405534005268 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 405534005269 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 405534005270 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 405534005271 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 405534005272 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 405534005273 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 405534005274 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 405534005275 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 405534005276 FliG C-terminal domain; Region: FliG_C; pfam01706 405534005277 flagellar assembly protein H; Validated; Region: fliH; PRK06800 405534005278 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 405534005279 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 405534005280 Walker A motif; other site 405534005281 ATP binding site [chemical binding]; other site 405534005282 Walker B motif; other site 405534005283 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 405534005284 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 405534005285 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 405534005286 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 405534005287 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 405534005288 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 405534005289 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 405534005290 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 405534005291 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 405534005292 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 405534005293 Response regulator receiver domain; Region: Response_reg; pfam00072 405534005294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534005295 active site 405534005296 phosphorylation site [posttranslational modification] 405534005297 intermolecular recognition site; other site 405534005298 dimerization interface [polypeptide binding]; other site 405534005299 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 405534005300 flagellin; Provisional; Region: PRK12807 405534005301 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 405534005302 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 405534005303 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 405534005304 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 405534005305 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 405534005306 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 405534005307 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 405534005308 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405534005309 catalytic residue [active] 405534005310 flagellar motor switch protein; Validated; Region: PRK06789 405534005311 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 405534005312 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 405534005313 flagellar motor switch protein; Validated; Region: PRK06788 405534005314 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 405534005315 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 405534005316 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 405534005317 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 405534005318 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 405534005319 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 405534005320 FHIPEP family; Region: FHIPEP; pfam00771 405534005321 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889 405534005322 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 405534005323 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 405534005324 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 405534005325 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 405534005326 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 405534005327 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 405534005328 Predicted transcriptional regulators [Transcription]; Region: COG1378 405534005329 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 405534005330 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 405534005331 C-terminal domain interface [polypeptide binding]; other site 405534005332 sugar binding site [chemical binding]; other site 405534005333 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 405534005334 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 405534005335 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 405534005336 Dienelactone hydrolase family; Region: DLH; pfam01738 405534005337 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 405534005338 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405534005339 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405534005340 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405534005341 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405534005342 Cna protein B-type domain; Region: Cna_B; pfam05738 405534005343 Cna protein B-type domain; Region: Cna_B; pfam05738 405534005344 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405534005345 Cna protein B-type domain; Region: Cna_B; pfam05738 405534005346 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 405534005347 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 405534005348 active site 405534005349 catalytic site [active] 405534005350 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 405534005351 active site 405534005352 catalytic site [active] 405534005353 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 405534005354 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534005355 non-specific DNA binding site [nucleotide binding]; other site 405534005356 salt bridge; other site 405534005357 sequence-specific DNA binding site [nucleotide binding]; other site 405534005358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534005359 H+ Antiporter protein; Region: 2A0121; TIGR00900 405534005360 putative substrate translocation pore; other site 405534005361 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 405534005362 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405534005363 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405534005364 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405534005365 dimerization interface [polypeptide binding]; other site 405534005366 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 405534005367 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534005368 Walker A/P-loop; other site 405534005369 ATP binding site [chemical binding]; other site 405534005370 Q-loop/lid; other site 405534005371 ABC transporter signature motif; other site 405534005372 Walker B; other site 405534005373 D-loop; other site 405534005374 H-loop/switch region; other site 405534005375 TOBE domain; Region: TOBE_2; pfam08402 405534005376 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 405534005377 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 405534005378 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 405534005379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534005380 dimer interface [polypeptide binding]; other site 405534005381 conserved gate region; other site 405534005382 putative PBP binding loops; other site 405534005383 ABC-ATPase subunit interface; other site 405534005384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534005385 dimer interface [polypeptide binding]; other site 405534005386 conserved gate region; other site 405534005387 putative PBP binding loops; other site 405534005388 ABC-ATPase subunit interface; other site 405534005389 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 405534005390 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 405534005391 Beta-Casp domain; Region: Beta-Casp; smart01027 405534005392 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 405534005393 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 405534005394 short chain dehydrogenase; Provisional; Region: PRK08226 405534005395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405534005396 NAD(P) binding site [chemical binding]; other site 405534005397 active site 405534005398 Cupin; Region: Cupin_1; smart00835 405534005399 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 405534005400 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 405534005401 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405534005402 catalytic core [active] 405534005403 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405534005404 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 405534005405 hypothetical protein; Provisional; Region: PRK09272 405534005406 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405534005407 MarR family; Region: MarR_2; pfam12802 405534005408 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 405534005409 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 405534005410 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 405534005411 active site 405534005412 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 405534005413 Ligand Binding Site [chemical binding]; other site 405534005414 Molecular Tunnel; other site 405534005415 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 405534005416 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 405534005417 putative active site [active] 405534005418 putative NTP binding site [chemical binding]; other site 405534005419 putative nucleic acid binding site [nucleotide binding]; other site 405534005420 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 405534005421 active site 405534005422 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 405534005423 RNA polymerase factor sigma-70; Validated; Region: PRK06811 405534005424 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405534005425 DNA binding residues [nucleotide binding] 405534005426 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 405534005427 VPS10 domain; Region: VPS10; smart00602 405534005428 VPS10 domain; Region: VPS10; smart00602 405534005429 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 405534005430 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 405534005431 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405534005432 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 405534005433 DNA-binding site [nucleotide binding]; DNA binding site 405534005434 FCD domain; Region: FCD; pfam07729 405534005435 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405534005436 EamA-like transporter family; Region: EamA; pfam00892 405534005437 EamA-like transporter family; Region: EamA; pfam00892 405534005438 Methyltransferase domain; Region: Methyltransf_24; pfam13578 405534005439 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 405534005440 fumarate hydratase; Reviewed; Region: fumC; PRK00485 405534005441 Class II fumarases; Region: Fumarase_classII; cd01362 405534005442 active site 405534005443 tetramer interface [polypeptide binding]; other site 405534005444 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 405534005445 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 405534005446 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 405534005447 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 405534005448 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 405534005449 active site pocket [active] 405534005450 oxyanion hole [active] 405534005451 catalytic triad [active] 405534005452 active site nucleophile [active] 405534005453 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 405534005454 Penicillinase repressor; Region: Pencillinase_R; pfam03965 405534005455 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 405534005456 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 405534005457 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 405534005458 catalytic residues [active] 405534005459 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 405534005460 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 405534005461 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534005462 non-specific DNA binding site [nucleotide binding]; other site 405534005463 salt bridge; other site 405534005464 sequence-specific DNA binding site [nucleotide binding]; other site 405534005465 Cupin domain; Region: Cupin_2; pfam07883 405534005466 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 405534005467 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 405534005468 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405534005469 catalytic residue [active] 405534005470 Protein of unknown function (DUF445); Region: DUF445; pfam04286 405534005471 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 405534005472 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405534005473 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405534005474 DNA binding residues [nucleotide binding] 405534005475 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405534005476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534005477 active site 405534005478 phosphorylation site [posttranslational modification] 405534005479 intermolecular recognition site; other site 405534005480 dimerization interface [polypeptide binding]; other site 405534005481 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405534005482 DNA binding residues [nucleotide binding] 405534005483 dimerization interface [polypeptide binding]; other site 405534005484 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405534005485 Histidine kinase; Region: HisKA_3; pfam07730 405534005486 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405534005487 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534005488 Walker A/P-loop; other site 405534005489 ATP binding site [chemical binding]; other site 405534005490 Q-loop/lid; other site 405534005491 ABC transporter signature motif; other site 405534005492 Walker B; other site 405534005493 D-loop; other site 405534005494 H-loop/switch region; other site 405534005495 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 405534005496 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 405534005497 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 405534005498 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 405534005499 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 405534005500 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405534005501 putative active site [active] 405534005502 catalytic site [active] 405534005503 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 405534005504 PLD-like domain; Region: PLDc_2; pfam13091 405534005505 putative active site [active] 405534005506 catalytic site [active] 405534005507 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 405534005508 putative nucleotide binding site [chemical binding]; other site 405534005509 uridine monophosphate binding site [chemical binding]; other site 405534005510 homohexameric interface [polypeptide binding]; other site 405534005511 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405534005512 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 405534005513 aspartate ammonia-lyase; Provisional; Region: PRK14515 405534005514 Aspartase; Region: Aspartase; cd01357 405534005515 active sites [active] 405534005516 tetramer interface [polypeptide binding]; other site 405534005517 malate dehydrogenase; Provisional; Region: PRK13529 405534005518 Malic enzyme, N-terminal domain; Region: malic; pfam00390 405534005519 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 405534005520 NAD(P) binding site [chemical binding]; other site 405534005521 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534005522 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534005523 ATP binding site [chemical binding]; other site 405534005524 Mg2+ binding site [ion binding]; other site 405534005525 G-X-G motif; other site 405534005526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534005527 Response regulator receiver domain; Region: Response_reg; pfam00072 405534005528 active site 405534005529 phosphorylation site [posttranslational modification] 405534005530 intermolecular recognition site; other site 405534005531 dimerization interface [polypeptide binding]; other site 405534005532 YcbB domain; Region: YcbB; pfam08664 405534005533 SWIM zinc finger; Region: SWIM; pfam04434 405534005534 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 405534005535 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 405534005536 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405534005537 ATP binding site [chemical binding]; other site 405534005538 putative Mg++ binding site [ion binding]; other site 405534005539 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405534005540 nucleotide binding region [chemical binding]; other site 405534005541 ATP-binding site [chemical binding]; other site 405534005542 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 405534005543 dimer interface [polypeptide binding]; other site 405534005544 active site 405534005545 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 405534005546 putative dimer interface [polypeptide binding]; other site 405534005547 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534005548 aspartate kinase; Reviewed; Region: PRK06635 405534005549 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 405534005550 putative nucleotide binding site [chemical binding]; other site 405534005551 putative catalytic residues [active] 405534005552 putative Mg ion binding site [ion binding]; other site 405534005553 putative aspartate binding site [chemical binding]; other site 405534005554 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 405534005555 putative allosteric regulatory site; other site 405534005556 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 405534005557 putative allosteric regulatory residue; other site 405534005558 Lysine riboswitch 405534005559 DoxX-like family; Region: DoxX_3; pfam13781 405534005560 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 405534005561 YndJ-like protein; Region: YndJ; pfam14158 405534005562 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 405534005563 putative active site [active] 405534005564 nucleotide binding site [chemical binding]; other site 405534005565 nudix motif; other site 405534005566 putative metal binding site [ion binding]; other site 405534005567 S-layer homology domain; Region: SLH; pfam00395 405534005568 S-layer homology domain; Region: SLH; pfam00395 405534005569 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 405534005570 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405534005571 active site 405534005572 metal binding site [ion binding]; metal-binding site 405534005573 S-layer homology domain; Region: SLH; pfam00395 405534005574 S-layer homology domain; Region: SLH; pfam00395 405534005575 S-layer homology domain; Region: SLH; pfam00395 405534005576 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 405534005577 H+ Antiporter protein; Region: 2A0121; TIGR00900 405534005578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534005579 putative substrate translocation pore; other site 405534005580 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 405534005581 Carbon starvation protein CstA; Region: CstA; pfam02554 405534005582 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 405534005583 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 405534005584 Predicted transcriptional regulators [Transcription]; Region: COG1695 405534005585 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405534005586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534005587 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534005588 putative substrate translocation pore; other site 405534005589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534005590 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534005591 putative substrate translocation pore; other site 405534005592 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 405534005593 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 405534005594 dimer interface [polypeptide binding]; other site 405534005595 active site 405534005596 CoA binding pocket [chemical binding]; other site 405534005597 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 405534005598 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 405534005599 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 405534005600 HflX GTPase family; Region: HflX; cd01878 405534005601 G1 box; other site 405534005602 GTP/Mg2+ binding site [chemical binding]; other site 405534005603 Switch I region; other site 405534005604 G2 box; other site 405534005605 G3 box; other site 405534005606 Switch II region; other site 405534005607 G4 box; other site 405534005608 G5 box; other site 405534005609 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405534005610 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405534005611 peptide binding site [polypeptide binding]; other site 405534005612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534005613 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534005614 putative substrate translocation pore; other site 405534005615 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 405534005616 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 405534005617 dimer interface [polypeptide binding]; other site 405534005618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534005619 catalytic residue [active] 405534005620 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534005621 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405534005622 Coenzyme A binding pocket [chemical binding]; other site 405534005623 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 405534005624 stage V sporulation protein B; Region: spore_V_B; TIGR02900 405534005625 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405534005626 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 405534005627 Na2 binding site [ion binding]; other site 405534005628 putative substrate binding site 1 [chemical binding]; other site 405534005629 Na binding site 1 [ion binding]; other site 405534005630 putative substrate binding site 2 [chemical binding]; other site 405534005631 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405534005632 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 405534005633 NodB motif; other site 405534005634 putative active site [active] 405534005635 putative catalytic site [active] 405534005636 putative Zn binding site [ion binding]; other site 405534005637 Mor transcription activator family; Region: Mor; cl02360 405534005638 Predicted membrane protein [Function unknown]; Region: COG2323 405534005639 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 405534005640 methionine sulfoxide reductase A; Provisional; Region: PRK14054 405534005641 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 405534005642 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 405534005643 homodimer interface [polypeptide binding]; other site 405534005644 substrate-cofactor binding pocket; other site 405534005645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534005646 catalytic residue [active] 405534005647 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 405534005648 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 405534005649 PYR/PP interface [polypeptide binding]; other site 405534005650 dimer interface [polypeptide binding]; other site 405534005651 TPP binding site [chemical binding]; other site 405534005652 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405534005653 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 405534005654 TPP-binding site [chemical binding]; other site 405534005655 dimer interface [polypeptide binding]; other site 405534005656 acetolactate synthase 1 regulatory subunit; Validated; Region: PRK06737 405534005657 ketol-acid reductoisomerase; Provisional; Region: PRK05479 405534005658 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 405534005659 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 405534005660 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 405534005661 threonine dehydratase; Validated; Region: PRK08639 405534005662 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 405534005663 tetramer interface [polypeptide binding]; other site 405534005664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534005665 catalytic residue [active] 405534005666 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 405534005667 putative Ile/Val binding site [chemical binding]; other site 405534005668 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 405534005669 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 405534005670 putative active site [active] 405534005671 putative metal binding site [ion binding]; other site 405534005672 Protein of unknown function (DUF554); Region: DUF554; pfam04474 405534005673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534005674 Coenzyme A binding pocket [chemical binding]; other site 405534005675 drug efflux system protein MdtG; Provisional; Region: PRK09874 405534005676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534005677 putative substrate translocation pore; other site 405534005678 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 405534005679 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 405534005680 putative active site [active] 405534005681 metal binding site [ion binding]; metal-binding site 405534005682 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 405534005683 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405534005684 LytTr DNA-binding domain; Region: LytTR; pfam04397 405534005685 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 405534005686 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 405534005687 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 405534005688 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 405534005689 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405534005690 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534005691 Coenzyme A binding pocket [chemical binding]; other site 405534005692 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 405534005693 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 405534005694 active site 405534005695 putative substrate binding pocket [chemical binding]; other site 405534005696 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405534005697 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405534005698 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405534005699 peptide binding site [polypeptide binding]; other site 405534005700 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405534005701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534005702 Coenzyme A binding pocket [chemical binding]; other site 405534005703 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534005704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534005705 active site 405534005706 phosphorylation site [posttranslational modification] 405534005707 intermolecular recognition site; other site 405534005708 dimerization interface [polypeptide binding]; other site 405534005709 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534005710 DNA binding site [nucleotide binding] 405534005711 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534005712 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534005713 dimerization interface [polypeptide binding]; other site 405534005714 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534005715 dimer interface [polypeptide binding]; other site 405534005716 phosphorylation site [posttranslational modification] 405534005717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534005718 ATP binding site [chemical binding]; other site 405534005719 Mg2+ binding site [ion binding]; other site 405534005720 G-X-G motif; other site 405534005721 Peptidase family M23; Region: Peptidase_M23; pfam01551 405534005722 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405534005723 manganese transport protein MntH; Reviewed; Region: PRK00701 405534005724 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 405534005725 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 405534005726 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 405534005727 active site residue [active] 405534005728 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 405534005729 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 405534005730 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 405534005731 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 405534005732 ydaO/yuaA leader 405534005733 Amino acid permease; Region: AA_permease_2; pfam13520 405534005734 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405534005735 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405534005736 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405534005737 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 405534005738 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405534005739 DNA binding residues [nucleotide binding] 405534005740 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 405534005741 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 405534005742 intersubunit interface [polypeptide binding]; other site 405534005743 active site 405534005744 catalytic residue [active] 405534005745 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405534005746 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405534005747 Nucleoside recognition; Region: Gate; pfam07670 405534005748 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405534005749 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 405534005750 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 405534005751 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 405534005752 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 405534005753 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 405534005754 active site 405534005755 catalytic motif [active] 405534005756 Zn binding site [ion binding]; other site 405534005757 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 405534005758 hypothetical protein; Provisional; Region: PRK01631 405534005759 proline aminopeptidase P II; Provisional; Region: PRK10879 405534005760 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 405534005761 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 405534005762 active site 405534005763 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 405534005764 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 405534005765 DNA topoisomerase III; Provisional; Region: PRK07726 405534005766 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 405534005767 active site 405534005768 putative interdomain interaction site [polypeptide binding]; other site 405534005769 putative metal-binding site [ion binding]; other site 405534005770 putative nucleotide binding site [chemical binding]; other site 405534005771 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 405534005772 domain I; other site 405534005773 DNA binding groove [nucleotide binding] 405534005774 phosphate binding site [ion binding]; other site 405534005775 domain II; other site 405534005776 domain III; other site 405534005777 nucleotide binding site [chemical binding]; other site 405534005778 catalytic site [active] 405534005779 domain IV; other site 405534005780 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 405534005781 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 405534005782 DNA binding domains of BfiI, EcoRII and plant B3 proteins; Region: BfiI_C_EcoRII_N_B3; cl15242 405534005783 DNA binding site [nucleotide binding] 405534005784 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 405534005785 Sodium Bile acid symporter family; Region: SBF; cl17470 405534005786 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 405534005787 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 405534005788 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405534005789 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534005790 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 405534005791 dimer interface [polypeptide binding]; other site 405534005792 substrate binding site [chemical binding]; other site 405534005793 metal binding site [ion binding]; metal-binding site 405534005794 CopC domain; Region: CopC; pfam04234 405534005795 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 405534005796 YtkA-like; Region: YtkA; pfam13115 405534005797 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 405534005798 EamA-like transporter family; Region: EamA; pfam00892 405534005799 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405534005800 EamA-like transporter family; Region: EamA; pfam00892 405534005801 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405534005802 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405534005803 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405534005804 dimerization interface [polypeptide binding]; other site 405534005805 Predicted transcriptional regulator [Transcription]; Region: COG1959 405534005806 Transcriptional regulator; Region: Rrf2; pfam02082 405534005807 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 405534005808 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 405534005809 catalytic residues [active] 405534005810 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 405534005811 dimer interface [polypeptide binding]; other site 405534005812 FMN binding site [chemical binding]; other site 405534005813 amidase; Provisional; Region: PRK06707 405534005814 Amidase; Region: Amidase; cl11426 405534005815 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 405534005816 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 405534005817 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 405534005818 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405534005819 NAD binding site [chemical binding]; other site 405534005820 dimer interface [polypeptide binding]; other site 405534005821 substrate binding site [chemical binding]; other site 405534005822 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 405534005823 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405534005824 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 405534005825 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 405534005826 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 405534005827 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 405534005828 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 405534005829 putative ligand binding site [chemical binding]; other site 405534005830 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 405534005831 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 405534005832 Walker A/P-loop; other site 405534005833 ATP binding site [chemical binding]; other site 405534005834 Q-loop/lid; other site 405534005835 ABC transporter signature motif; other site 405534005836 Walker B; other site 405534005837 D-loop; other site 405534005838 H-loop/switch region; other site 405534005839 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 405534005840 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 405534005841 Walker A/P-loop; other site 405534005842 ATP binding site [chemical binding]; other site 405534005843 Q-loop/lid; other site 405534005844 ABC transporter signature motif; other site 405534005845 Walker B; other site 405534005846 D-loop; other site 405534005847 H-loop/switch region; other site 405534005848 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405534005849 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 405534005850 TM-ABC transporter signature motif; other site 405534005851 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 405534005852 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 405534005853 TM-ABC transporter signature motif; other site 405534005854 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405534005855 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405534005856 LysR substrate binding domain; Region: LysR_substrate; pfam03466 405534005857 dimerization interface [polypeptide binding]; other site 405534005858 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 405534005859 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405534005860 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534005861 putative Zn2+ binding site [ion binding]; other site 405534005862 putative DNA binding site [nucleotide binding]; other site 405534005863 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 405534005864 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 405534005865 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 405534005866 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 405534005867 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 405534005868 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 405534005869 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 405534005870 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 405534005871 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405534005872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534005873 Walker A/P-loop; other site 405534005874 ATP binding site [chemical binding]; other site 405534005875 Q-loop/lid; other site 405534005876 ABC transporter signature motif; other site 405534005877 Walker B; other site 405534005878 D-loop; other site 405534005879 H-loop/switch region; other site 405534005880 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 405534005881 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405534005882 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 405534005883 Walker A/P-loop; other site 405534005884 ATP binding site [chemical binding]; other site 405534005885 Q-loop/lid; other site 405534005886 ABC transporter signature motif; other site 405534005887 Walker B; other site 405534005888 D-loop; other site 405534005889 H-loop/switch region; other site 405534005890 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405534005891 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405534005892 active site 405534005893 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405534005894 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 405534005895 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405534005896 active site 405534005897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534005898 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405534005899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 405534005900 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 405534005901 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 405534005902 inhibitor-cofactor binding pocket; inhibition site 405534005903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534005904 catalytic residue [active] 405534005905 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 405534005906 trimer interface [polypeptide binding]; other site 405534005907 active site 405534005908 substrate binding site [chemical binding]; other site 405534005909 CoA binding site [chemical binding]; other site 405534005910 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 405534005911 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 405534005912 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405534005913 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 405534005914 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 405534005915 dimer interface [polypeptide binding]; other site 405534005916 FMN binding site [chemical binding]; other site 405534005917 Bacterial SH3 domain; Region: SH3_3; pfam08239 405534005918 Bacterial SH3 domain; Region: SH3_3; pfam08239 405534005919 Bacterial SH3 domain; Region: SH3_3; pfam08239 405534005920 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405534005921 NlpC/P60 family; Region: NLPC_P60; pfam00877 405534005922 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405534005923 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405534005924 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405534005925 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534005926 Walker A/P-loop; other site 405534005927 ATP binding site [chemical binding]; other site 405534005928 Q-loop/lid; other site 405534005929 ABC transporter signature motif; other site 405534005930 Walker B; other site 405534005931 D-loop; other site 405534005932 H-loop/switch region; other site 405534005933 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534005934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534005935 active site 405534005936 phosphorylation site [posttranslational modification] 405534005937 intermolecular recognition site; other site 405534005938 dimerization interface [polypeptide binding]; other site 405534005939 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534005940 DNA binding site [nucleotide binding] 405534005941 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534005942 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534005943 dimerization interface [polypeptide binding]; other site 405534005944 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534005945 dimer interface [polypeptide binding]; other site 405534005946 phosphorylation site [posttranslational modification] 405534005947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534005948 ATP binding site [chemical binding]; other site 405534005949 Mg2+ binding site [ion binding]; other site 405534005950 G-X-G motif; other site 405534005951 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 405534005952 classical (c) SDRs; Region: SDR_c; cd05233 405534005953 NAD(P) binding site [chemical binding]; other site 405534005954 active site 405534005955 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 405534005956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534005957 S-adenosylmethionine binding site [chemical binding]; other site 405534005958 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 405534005959 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405534005960 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 405534005961 NodB motif; other site 405534005962 active site 405534005963 catalytic site [active] 405534005964 metal binding site [ion binding]; metal-binding site 405534005965 SdpI/YhfL protein family; Region: SdpI; pfam13630 405534005966 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 405534005967 nudix motif; other site 405534005968 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 405534005969 homoserine dehydrogenase; Provisional; Region: PRK06349 405534005970 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 405534005971 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 405534005972 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 405534005973 threonine synthase; Reviewed; Region: PRK06721 405534005974 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 405534005975 homodimer interface [polypeptide binding]; other site 405534005976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534005977 catalytic residue [active] 405534005978 homoserine kinase; Provisional; Region: PRK01212 405534005979 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 405534005980 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 405534005981 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 405534005982 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 405534005983 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534005984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534005985 ATP binding site [chemical binding]; other site 405534005986 Mg2+ binding site [ion binding]; other site 405534005987 G-X-G motif; other site 405534005988 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405534005989 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 405534005990 NodB motif; other site 405534005991 active site 405534005992 catalytic site [active] 405534005993 Zn binding site [ion binding]; other site 405534005994 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 405534005995 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 405534005996 MgtC family; Region: MgtC; pfam02308 405534005997 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405534005998 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534005999 Coenzyme A binding pocket [chemical binding]; other site 405534006000 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405534006001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534006002 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534006003 putative substrate translocation pore; other site 405534006004 Lysine efflux permease [General function prediction only]; Region: COG1279 405534006005 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405534006006 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405534006007 DNA-binding site [nucleotide binding]; DNA binding site 405534006008 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405534006009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534006010 homodimer interface [polypeptide binding]; other site 405534006011 catalytic residue [active] 405534006012 Protein of unknown function (DUF3933); Region: DUF3933; pfam13069 405534006013 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 405534006014 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 405534006015 active site 405534006016 nucleophile elbow; other site 405534006017 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 405534006018 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 405534006019 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 405534006020 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 405534006021 nudix motif; other site 405534006022 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 405534006023 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 405534006024 homodimer interface [polypeptide binding]; other site 405534006025 NAD binding pocket [chemical binding]; other site 405534006026 ATP binding pocket [chemical binding]; other site 405534006027 Mg binding site [ion binding]; other site 405534006028 active-site loop [active] 405534006029 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405534006030 FtsX-like permease family; Region: FtsX; pfam02687 405534006031 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 405534006032 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 405534006033 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 405534006034 active site 405534006035 catalytic residues [active] 405534006036 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 405534006037 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 405534006038 Walker A/P-loop; other site 405534006039 ATP binding site [chemical binding]; other site 405534006040 Q-loop/lid; other site 405534006041 ABC transporter signature motif; other site 405534006042 Walker B; other site 405534006043 D-loop; other site 405534006044 H-loop/switch region; other site 405534006045 TOBE domain; Region: TOBE_2; pfam08402 405534006046 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 405534006047 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 405534006048 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405534006049 carbohydrate ABC transporter substrate-binding protein, CPR_0540 family; Region: bind_CPR_0540; TIGR03850 405534006050 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 405534006051 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 405534006052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534006053 dimer interface [polypeptide binding]; other site 405534006054 conserved gate region; other site 405534006055 putative PBP binding loops; other site 405534006056 ABC-ATPase subunit interface; other site 405534006057 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 405534006058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534006059 dimer interface [polypeptide binding]; other site 405534006060 conserved gate region; other site 405534006061 putative PBP binding loops; other site 405534006062 ABC-ATPase subunit interface; other site 405534006063 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 405534006064 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 405534006065 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 405534006066 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405534006067 nucleotide binding site [chemical binding]; other site 405534006068 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 405534006069 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 405534006070 dimer interface [polypeptide binding]; other site 405534006071 active site 405534006072 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 405534006073 putative active site [active] 405534006074 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 405534006075 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 405534006076 active site 405534006077 dimer interface [polypeptide binding]; other site 405534006078 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 405534006079 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 405534006080 putative substrate binding site [chemical binding]; other site 405534006081 putative ATP binding site [chemical binding]; other site 405534006082 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 405534006083 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 405534006084 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 405534006085 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 405534006086 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 405534006087 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 405534006088 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534006089 dimerization interface [polypeptide binding]; other site 405534006090 putative DNA binding site [nucleotide binding]; other site 405534006091 putative Zn2+ binding site [ion binding]; other site 405534006092 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405534006093 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405534006094 active site 405534006095 catalytic tetrad [active] 405534006096 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 405534006097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534006098 putative substrate translocation pore; other site 405534006099 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 405534006100 Protein of unknown function (DUF664); Region: DUF664; pfam04978 405534006101 DinB superfamily; Region: DinB_2; pfam12867 405534006102 GTPase RsgA; Reviewed; Region: PRK01889 405534006103 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 405534006104 RNA binding site [nucleotide binding]; other site 405534006105 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 405534006106 GTPase/Zn-binding domain interface [polypeptide binding]; other site 405534006107 GTP/Mg2+ binding site [chemical binding]; other site 405534006108 G4 box; other site 405534006109 G5 box; other site 405534006110 G1 box; other site 405534006111 Switch I region; other site 405534006112 G2 box; other site 405534006113 G3 box; other site 405534006114 Switch II region; other site 405534006115 Tar ligand binding domain homologue; Region: TarH; pfam02203 405534006116 Cache domain; Region: Cache_1; pfam02743 405534006117 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 405534006118 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534006119 dimerization interface [polypeptide binding]; other site 405534006120 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405534006121 dimer interface [polypeptide binding]; other site 405534006122 putative CheW interface [polypeptide binding]; other site 405534006123 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 405534006124 Uncharacterized membrane protein [Function unknown]; Region: COG3949 405534006125 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 405534006126 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 405534006127 dimerization interface [polypeptide binding]; other site 405534006128 DPS ferroxidase diiron center [ion binding]; other site 405534006129 ion pore; other site 405534006130 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 405534006131 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 405534006132 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 405534006133 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 405534006134 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 405534006135 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 405534006136 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405534006137 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405534006138 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405534006139 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405534006140 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405534006141 active site 405534006142 catalytic tetrad [active] 405534006143 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 405534006144 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 405534006145 P-loop, Walker A motif; other site 405534006146 Base recognition motif; other site 405534006147 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 405534006148 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405534006149 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534006150 Coenzyme A binding pocket [chemical binding]; other site 405534006151 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 405534006152 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 405534006153 metal binding site [ion binding]; metal-binding site 405534006154 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 405534006155 NADH(P)-binding; Region: NAD_binding_10; pfam13460 405534006156 NAD binding site [chemical binding]; other site 405534006157 active site 405534006158 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 405534006159 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 405534006160 active site 405534006161 FMN binding site [chemical binding]; other site 405534006162 substrate binding site [chemical binding]; other site 405534006163 homotetramer interface [polypeptide binding]; other site 405534006164 catalytic residue [active] 405534006165 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 405534006166 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 405534006167 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 405534006168 DNA binding site [nucleotide binding] 405534006169 active site 405534006170 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 405534006171 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405534006172 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405534006173 peptide binding site [polypeptide binding]; other site 405534006174 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 405534006175 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405534006176 active site 405534006177 metal binding site [ion binding]; metal-binding site 405534006178 short chain dehydrogenase; Provisional; Region: PRK08309 405534006179 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405534006180 catalytic core [active] 405534006181 CotH protein; Region: CotH; pfam08757 405534006182 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 405534006183 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 405534006184 nudix motif; other site 405534006185 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405534006186 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405534006187 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 405534006188 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405534006189 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 405534006190 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 405534006191 Cl binding site [ion binding]; other site 405534006192 oligomer interface [polypeptide binding]; other site 405534006193 Predicted permeases [General function prediction only]; Region: COG0701 405534006194 Predicted membrane protein [Function unknown]; Region: COG3689 405534006195 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 405534006196 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 405534006197 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405534006198 putative active site [active] 405534006199 catalytic site [active] 405534006200 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 405534006201 putative active site [active] 405534006202 catalytic site [active] 405534006203 Coat F domain; Region: Coat_F; pfam07875 405534006204 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 405534006205 NADH(P)-binding; Region: NAD_binding_10; pfam13460 405534006206 NAD binding site [chemical binding]; other site 405534006207 substrate binding site [chemical binding]; other site 405534006208 putative active site [active] 405534006209 Protein of unknown function (DUF456); Region: DUF456; pfam04306 405534006210 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 405534006211 Domain of unknown function DUF21; Region: DUF21; pfam01595 405534006212 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 405534006213 Transporter associated domain; Region: CorC_HlyC; smart01091 405534006214 FOG: CBS domain [General function prediction only]; Region: COG0517 405534006215 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 405534006216 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405534006217 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 405534006218 dimer interface [polypeptide binding]; other site 405534006219 putative tRNA-binding site [nucleotide binding]; other site 405534006220 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 405534006221 DinB superfamily; Region: DinB_2; pfam12867 405534006222 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 405534006223 stage II sporulation protein P; Region: spore_II_P; TIGR02867 405534006224 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405534006225 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534006226 Coenzyme A binding pocket [chemical binding]; other site 405534006227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405534006228 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 405534006229 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 405534006230 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 405534006231 nudix motif; other site 405534006232 amidase; Provisional; Region: PRK06828 405534006233 Amidase; Region: Amidase; pfam01425 405534006234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534006235 putative substrate translocation pore; other site 405534006236 H+ Antiporter protein; Region: 2A0121; TIGR00900 405534006237 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 405534006238 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 405534006239 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 405534006240 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405534006241 catalytic core [active] 405534006242 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534006243 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405534006244 active site 405534006245 motif I; other site 405534006246 motif II; other site 405534006247 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534006248 DinB superfamily; Region: DinB_2; pfam12867 405534006249 DinB family; Region: DinB; cl17821 405534006250 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 405534006251 alanine racemase; Reviewed; Region: alr; PRK00053 405534006252 active site 405534006253 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405534006254 dimer interface [polypeptide binding]; other site 405534006255 substrate binding site [chemical binding]; other site 405534006256 catalytic residues [active] 405534006257 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405534006258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534006259 S-adenosylmethionine binding site [chemical binding]; other site 405534006260 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534006261 Coenzyme A binding pocket [chemical binding]; other site 405534006262 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534006263 Coenzyme A binding pocket [chemical binding]; other site 405534006264 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 405534006265 glycosyltransferase, MGT family; Region: MGT; TIGR01426 405534006266 active site 405534006267 TDP-binding site; other site 405534006268 acceptor substrate-binding pocket; other site 405534006269 homodimer interface [polypeptide binding]; other site 405534006270 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405534006271 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405534006272 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405534006273 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405534006274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405534006275 DNA-binding site [nucleotide binding]; DNA binding site 405534006276 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405534006277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534006278 homodimer interface [polypeptide binding]; other site 405534006279 catalytic residue [active] 405534006280 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534006281 Coenzyme A binding pocket [chemical binding]; other site 405534006282 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405534006283 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 405534006284 active site 405534006285 metal binding site [ion binding]; metal-binding site 405534006286 Src Homology 3 domain superfamily; Region: SH3; cl17036 405534006287 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 405534006288 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405534006289 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534006290 Coenzyme A binding pocket [chemical binding]; other site 405534006291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405534006292 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 405534006293 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405534006294 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534006295 Coenzyme A binding pocket [chemical binding]; other site 405534006296 Cupin domain; Region: Cupin_2; cl17218 405534006297 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534006298 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405534006299 Coenzyme A binding pocket [chemical binding]; other site 405534006300 Predicted acetyltransferase [General function prediction only]; Region: COG3393 405534006301 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534006302 Coenzyme A binding pocket [chemical binding]; other site 405534006303 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 405534006304 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405534006305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534006306 S-adenosylmethionine binding site [chemical binding]; other site 405534006307 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 405534006308 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 405534006309 Potassium binding sites [ion binding]; other site 405534006310 Cesium cation binding sites [ion binding]; other site 405534006311 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 405534006312 DEAD-like helicases superfamily; Region: DEXDc; smart00487 405534006313 ATP binding site [chemical binding]; other site 405534006314 putative Mg++ binding site [ion binding]; other site 405534006315 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405534006316 nucleotide binding region [chemical binding]; other site 405534006317 ATP-binding site [chemical binding]; other site 405534006318 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534006319 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 405534006320 integrase; Provisional; Region: int; PHA02601 405534006321 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 405534006322 Int/Topo IB signature motif; other site 405534006323 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 405534006324 sequence-specific DNA binding site [nucleotide binding]; other site 405534006325 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405534006326 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534006327 non-specific DNA binding site [nucleotide binding]; other site 405534006328 salt bridge; other site 405534006329 sequence-specific DNA binding site [nucleotide binding]; other site 405534006330 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534006331 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405534006332 non-specific DNA binding site [nucleotide binding]; other site 405534006333 salt bridge; other site 405534006334 sequence-specific DNA binding site [nucleotide binding]; other site 405534006335 Helix-turn-helix domain; Region: HTH_17; pfam12728 405534006336 phage conserved hypothetical protein, C-terminal domain; Region: phg_TIGR02220 405534006337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 405534006338 Walker A motif; other site 405534006339 ATP binding site [chemical binding]; other site 405534006340 Walker B motif; other site 405534006341 arginine finger; other site 405534006342 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 405534006343 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 405534006344 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 405534006345 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 405534006346 putative metal binding site [ion binding]; other site 405534006347 YopX protein; Region: YopX; pfam09643 405534006348 Protein of unknown function (DUF3983); Region: DUF3983; pfam13137 405534006349 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 405534006350 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405534006351 active site 405534006352 DNA binding site [nucleotide binding] 405534006353 Int/Topo IB signature motif; other site 405534006354 HNH endonuclease; Region: HNH; pfam01844 405534006355 Phage terminase, small subunit; Region: Terminase_4; pfam05119 405534006356 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 405534006357 Phage-related protein [Function unknown]; Region: COG4695 405534006358 Phage portal protein; Region: Phage_portal; pfam04860 405534006359 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 405534006360 oligomer interface [polypeptide binding]; other site 405534006361 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 405534006362 active site residues [active] 405534006363 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 405534006364 Phage capsid family; Region: Phage_capsid; pfam05065 405534006365 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 405534006366 oligomerization interface [polypeptide binding]; other site 405534006367 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 405534006368 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 405534006369 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 405534006370 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 405534006371 putative phage tail component, N-terminal domain; Region: phi3626_gp14_N; TIGR01633 405534006372 Phage tail protein; Region: Sipho_tail; cl17486 405534006373 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 405534006374 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 405534006375 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 405534006376 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 405534006377 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 405534006378 active site 405534006379 catalytic residues [active] 405534006380 DNA binding site [nucleotide binding] 405534006381 Int/Topo IB signature motif; other site 405534006382 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 405534006383 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 405534006384 active site 405534006385 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 405534006386 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534006387 non-specific DNA binding site [nucleotide binding]; other site 405534006388 salt bridge; other site 405534006389 sequence-specific DNA binding site [nucleotide binding]; other site 405534006390 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 405534006391 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 405534006392 Replication-relaxation; Region: Replic_Relax; pfam13814 405534006393 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405534006394 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405534006395 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 405534006396 NADP binding site [chemical binding]; other site 405534006397 dimer interface [polypeptide binding]; other site 405534006398 RNA polymerase sigma factor; Provisional; Region: PRK12543 405534006399 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405534006400 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405534006401 DNA binding residues [nucleotide binding] 405534006402 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 405534006403 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405534006404 Protein of unknown function (DUF3925); Region: DUF3925; pfam13063 405534006405 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 405534006406 catalytic residues [active] 405534006407 dimer interface [polypeptide binding]; other site 405534006408 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 405534006409 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 405534006410 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 405534006411 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 405534006412 Protein of unknown function DUF58; Region: DUF58; pfam01882 405534006413 MoxR-like ATPases [General function prediction only]; Region: COG0714 405534006414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534006415 Walker A motif; other site 405534006416 ATP binding site [chemical binding]; other site 405534006417 Walker B motif; other site 405534006418 arginine finger; other site 405534006419 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 405534006420 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 405534006421 [4Fe-4S] binding site [ion binding]; other site 405534006422 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405534006423 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405534006424 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405534006425 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 405534006426 molybdopterin cofactor binding site; other site 405534006427 nitrate reductase, beta subunit; Region: narH; TIGR01660 405534006428 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 405534006429 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 405534006430 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 405534006431 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405534006432 ligand binding site [chemical binding]; other site 405534006433 flexible hinge region; other site 405534006434 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 405534006435 putative switch regulator; other site 405534006436 non-specific DNA interactions [nucleotide binding]; other site 405534006437 DNA binding site [nucleotide binding] 405534006438 sequence specific DNA binding site [nucleotide binding]; other site 405534006439 putative cAMP binding site [chemical binding]; other site 405534006440 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 405534006441 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405534006442 FeS/SAM binding site; other site 405534006443 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 405534006444 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 405534006445 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 405534006446 ATP binding site [chemical binding]; other site 405534006447 substrate interface [chemical binding]; other site 405534006448 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 405534006449 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 405534006450 dimer interface [polypeptide binding]; other site 405534006451 putative functional site; other site 405534006452 putative MPT binding site; other site 405534006453 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 405534006454 MoaE homodimer interface [polypeptide binding]; other site 405534006455 MoaD interaction [polypeptide binding]; other site 405534006456 active site residues [active] 405534006457 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 405534006458 MoaE interaction surface [polypeptide binding]; other site 405534006459 MoeB interaction surface [polypeptide binding]; other site 405534006460 thiocarboxylated glycine; other site 405534006461 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 405534006462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534006463 putative substrate translocation pore; other site 405534006464 PspC domain; Region: PspC; pfam04024 405534006465 Predicted permeases [General function prediction only]; Region: COG0679 405534006466 precorrin-2 dehydrogenase; Validated; Region: PRK06719 405534006467 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 405534006468 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 405534006469 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 405534006470 putative active site [active] 405534006471 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 405534006472 putative active site [active] 405534006473 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 405534006474 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 405534006475 active site 405534006476 SAM binding site [chemical binding]; other site 405534006477 homodimer interface [polypeptide binding]; other site 405534006478 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 405534006479 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 405534006480 [2Fe-2S] cluster binding site [ion binding]; other site 405534006481 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 405534006482 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405534006483 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405534006484 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 405534006485 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 405534006486 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 405534006487 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 405534006488 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 405534006489 Hemerythrin-like domain; Region: Hr-like; cd12108 405534006490 Fe binding site [ion binding]; other site 405534006491 Excalibur calcium-binding domain; Region: Excalibur; smart00894 405534006492 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 405534006493 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 405534006494 PGAP1-like protein; Region: PGAP1; pfam07819 405534006495 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 405534006496 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 405534006497 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 405534006498 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405534006499 Zn2+ binding site [ion binding]; other site 405534006500 Mg2+ binding site [ion binding]; other site 405534006501 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 405534006502 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405534006503 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405534006504 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405534006505 ABC transporter; Region: ABC_tran_2; pfam12848 405534006506 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405534006507 Bax inhibitor 1 like; Region: BaxI_1; cl17691 405534006508 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 405534006509 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 405534006510 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 405534006511 dimer interface [polypeptide binding]; other site 405534006512 ssDNA binding site [nucleotide binding]; other site 405534006513 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405534006514 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534006515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534006516 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 405534006517 Virulence factor; Region: Virulence_fact; pfam13769 405534006518 HEAT repeats; Region: HEAT_2; pfam13646 405534006519 HEAT repeats; Region: HEAT_2; pfam13646 405534006520 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 405534006521 Protein of unknown function, DUF393; Region: DUF393; pfam04134 405534006522 Disulphide isomerase; Region: Disulph_isomer; pfam06491 405534006523 Brix domain; Region: Brix; cl00935 405534006524 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 405534006525 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 405534006526 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 405534006527 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 405534006528 active site 405534006529 HIGH motif; other site 405534006530 KMSK motif region; other site 405534006531 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 405534006532 tRNA binding surface [nucleotide binding]; other site 405534006533 anticodon binding site; other site 405534006534 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 405534006535 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405534006536 Methyltransferase domain; Region: Methyltransf_12; pfam08242 405534006537 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 405534006538 putative catalytic site [active] 405534006539 putative phosphate binding site [ion binding]; other site 405534006540 putative metal binding site [ion binding]; other site 405534006541 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405534006542 binding surface 405534006543 TPR motif; other site 405534006544 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 405534006545 putative active site [active] 405534006546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405534006547 binding surface 405534006548 TPR motif; other site 405534006549 TPR repeat; Region: TPR_11; pfam13414 405534006550 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405534006551 binding surface 405534006552 TPR motif; other site 405534006553 Tetratricopeptide repeat; Region: TPR_16; pfam13432 405534006554 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405534006555 binding surface 405534006556 TPR motif; other site 405534006557 TPR repeat; Region: TPR_11; pfam13414 405534006558 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405534006559 TPR motif; other site 405534006560 TPR repeat; Region: TPR_11; pfam13414 405534006561 binding surface 405534006562 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405534006563 binding surface 405534006564 TPR motif; other site 405534006565 Tetratricopeptide repeat; Region: TPR_16; pfam13432 405534006566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405534006567 binding surface 405534006568 TPR motif; other site 405534006569 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 405534006570 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 405534006571 HIGH motif; other site 405534006572 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 405534006573 active site 405534006574 KMSKS motif; other site 405534006575 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 405534006576 tRNA binding surface [nucleotide binding]; other site 405534006577 anticodon binding site; other site 405534006578 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405534006579 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405534006580 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 405534006581 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 405534006582 Zn binding site [ion binding]; other site 405534006583 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 405534006584 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 405534006585 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405534006586 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405534006587 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 405534006588 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 405534006589 Dimer interface [polypeptide binding]; other site 405534006590 anticodon binding site; other site 405534006591 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 405534006592 homodimer interface [polypeptide binding]; other site 405534006593 motif 1; other site 405534006594 motif 2; other site 405534006595 active site 405534006596 motif 3; other site 405534006597 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 405534006598 Na2 binding site [ion binding]; other site 405534006599 putative substrate binding site 1 [chemical binding]; other site 405534006600 Na binding site 1 [ion binding]; other site 405534006601 putative substrate binding site 2 [chemical binding]; other site 405534006602 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405534006603 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 405534006604 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 405534006605 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 405534006606 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534006607 motif II; other site 405534006608 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 405534006609 fructuronate transporter; Provisional; Region: PRK10034; cl15264 405534006610 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 405534006611 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 405534006612 active site 405534006613 NAD binding site [chemical binding]; other site 405534006614 metal binding site [ion binding]; metal-binding site 405534006615 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 405534006616 aspartate racemase; Region: asp_race; TIGR00035 405534006617 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 405534006618 homodimer interaction site [polypeptide binding]; other site 405534006619 cofactor binding site; other site 405534006620 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405534006621 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534006622 Coenzyme A binding pocket [chemical binding]; other site 405534006623 hypothetical protein; Validated; Region: PRK06769 405534006624 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534006625 active site 405534006626 motif I; other site 405534006627 motif II; other site 405534006628 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405534006629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534006630 Coenzyme A binding pocket [chemical binding]; other site 405534006631 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405534006632 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405534006633 Walker A/P-loop; other site 405534006634 ATP binding site [chemical binding]; other site 405534006635 Q-loop/lid; other site 405534006636 ABC transporter signature motif; other site 405534006637 Walker B; other site 405534006638 D-loop; other site 405534006639 H-loop/switch region; other site 405534006640 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 405534006641 YpjP-like protein; Region: YpjP; pfam14005 405534006642 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 405534006643 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534006644 motif II; other site 405534006645 hypothetical protein; Provisional; Region: PRK06724 405534006646 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534006647 active site 405534006648 metal binding site [ion binding]; metal-binding site 405534006649 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405534006650 Phosphotransferase enzyme family; Region: APH; pfam01636 405534006651 substrate binding site [chemical binding]; other site 405534006652 Beta-lactamase; Region: Beta-lactamase; pfam00144 405534006653 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405534006654 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 405534006655 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 405534006656 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 405534006657 thymidylate synthase; Region: thym_sym; TIGR03284 405534006658 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 405534006659 dimerization interface [polypeptide binding]; other site 405534006660 active site 405534006661 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 405534006662 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 405534006663 folate binding site [chemical binding]; other site 405534006664 NADP+ binding site [chemical binding]; other site 405534006665 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 405534006666 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405534006667 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 405534006668 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405534006669 azoreductase; Reviewed; Region: PRK00170 405534006670 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405534006671 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 405534006672 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 405534006673 putative acyl-acceptor binding pocket; other site 405534006674 Haemolysin-III related; Region: HlyIII; cl03831 405534006675 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 405534006676 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 405534006677 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 405534006678 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 405534006679 EDD domain protein, DegV family; Region: DegV; TIGR00762 405534006680 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 405534006681 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 405534006682 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 405534006683 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 405534006684 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 405534006685 Cu(I) binding site [ion binding]; other site 405534006686 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 405534006687 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 405534006688 putative dimer interface [polypeptide binding]; other site 405534006689 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 405534006690 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 405534006691 active site 405534006692 dimer interface [polypeptide binding]; other site 405534006693 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 405534006694 Ligand Binding Site [chemical binding]; other site 405534006695 Molecular Tunnel; other site 405534006696 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405534006697 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 405534006698 active site 405534006699 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405534006700 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 405534006701 siderophore binding site; other site 405534006702 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 405534006703 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 405534006704 homodimer interface [polypeptide binding]; other site 405534006705 substrate-cofactor binding pocket; other site 405534006706 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534006707 catalytic residue [active] 405534006708 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 405534006709 FMN binding site [chemical binding]; other site 405534006710 dimer interface [polypeptide binding]; other site 405534006711 Isochorismatase family; Region: Isochorismatase; pfam00857 405534006712 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 405534006713 catalytic triad [active] 405534006714 conserved cis-peptide bond; other site 405534006715 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 405534006716 nudix motif; other site 405534006717 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 405534006718 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 405534006719 putative dimer interface [polypeptide binding]; other site 405534006720 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 405534006721 Mechanosensitive ion channel; Region: MS_channel; pfam00924 405534006722 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 405534006723 GAF domain; Region: GAF; pfam01590 405534006724 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405534006725 Histidine kinase; Region: HisKA_3; pfam07730 405534006726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534006727 ATP binding site [chemical binding]; other site 405534006728 Mg2+ binding site [ion binding]; other site 405534006729 G-X-G motif; other site 405534006730 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405534006731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534006732 active site 405534006733 phosphorylation site [posttranslational modification] 405534006734 intermolecular recognition site; other site 405534006735 dimerization interface [polypeptide binding]; other site 405534006736 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405534006737 DNA binding residues [nucleotide binding] 405534006738 dimerization interface [polypeptide binding]; other site 405534006739 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 405534006740 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 405534006741 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 405534006742 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 405534006743 putative active site [active] 405534006744 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 405534006745 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 405534006746 NAD binding site [chemical binding]; other site 405534006747 substrate binding site [chemical binding]; other site 405534006748 catalytic Zn binding site [ion binding]; other site 405534006749 tetramer interface [polypeptide binding]; other site 405534006750 structural Zn binding site [ion binding]; other site 405534006751 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405534006752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534006753 dimer interface [polypeptide binding]; other site 405534006754 conserved gate region; other site 405534006755 ABC-ATPase subunit interface; other site 405534006756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534006757 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405534006758 dimer interface [polypeptide binding]; other site 405534006759 conserved gate region; other site 405534006760 putative PBP binding loops; other site 405534006761 ABC-ATPase subunit interface; other site 405534006762 Beta-lactamase; Region: Beta-lactamase; pfam00144 405534006763 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405534006764 Erythromycin esterase; Region: Erythro_esteras; pfam05139 405534006765 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405534006766 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405534006767 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405534006768 active site 405534006769 Predicted flavoprotein [General function prediction only]; Region: COG0431 405534006770 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405534006771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534006772 H+ Antiporter protein; Region: 2A0121; TIGR00900 405534006773 putative substrate translocation pore; other site 405534006774 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 405534006775 Uncharacterized conserved protein [Function unknown]; Region: COG1434 405534006776 putative active site [active] 405534006777 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 405534006778 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 405534006779 Walker A/P-loop; other site 405534006780 ATP binding site [chemical binding]; other site 405534006781 Q-loop/lid; other site 405534006782 ABC transporter signature motif; other site 405534006783 Walker B; other site 405534006784 D-loop; other site 405534006785 H-loop/switch region; other site 405534006786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534006787 dimer interface [polypeptide binding]; other site 405534006788 conserved gate region; other site 405534006789 ABC-ATPase subunit interface; other site 405534006790 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 405534006791 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 405534006792 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 405534006793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 405534006794 Protein of unknown function (DUF524); Region: DUF524; pfam04411 405534006795 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 405534006796 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 405534006797 DNA binding residues [nucleotide binding] 405534006798 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 405534006799 Domain of unknown function DUF21; Region: DUF21; pfam01595 405534006800 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 405534006801 Transporter associated domain; Region: CorC_HlyC; smart01091 405534006802 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 405534006803 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 405534006804 NAD(P) binding site [chemical binding]; other site 405534006805 catalytic residues [active] 405534006806 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 405534006807 Histidine kinase N terminal; Region: HisK_N; pfam09385 405534006808 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534006809 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534006810 dimer interface [polypeptide binding]; other site 405534006811 phosphorylation site [posttranslational modification] 405534006812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534006813 ATP binding site [chemical binding]; other site 405534006814 Mg2+ binding site [ion binding]; other site 405534006815 G-X-G motif; other site 405534006816 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 405534006817 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 405534006818 hypothetical protein; Provisional; Region: PRK06917 405534006819 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405534006820 inhibitor-cofactor binding pocket; inhibition site 405534006821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534006822 catalytic residue [active] 405534006823 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 405534006824 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 405534006825 acetylornithine deacetylase; Validated; Region: PRK06915 405534006826 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 405534006827 metal binding site [ion binding]; metal-binding site 405534006828 dimer interface [polypeptide binding]; other site 405534006829 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 405534006830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405534006831 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 405534006832 PAS fold; Region: PAS_4; pfam08448 405534006833 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 405534006834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534006835 Walker A motif; other site 405534006836 ATP binding site [chemical binding]; other site 405534006837 Walker B motif; other site 405534006838 arginine finger; other site 405534006839 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405534006840 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 405534006841 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405534006842 FeS/SAM binding site; other site 405534006843 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 405534006844 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 405534006845 toxin interface [polypeptide binding]; other site 405534006846 Zn binding site [ion binding]; other site 405534006847 hypothetical protein; Provisional; Region: PRK13672 405534006848 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 405534006849 YozD-like protein; Region: YozD; pfam14162 405534006850 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 405534006851 Catalytic domain of Protein Kinases; Region: PKc; cd00180 405534006852 active site 405534006853 ATP binding site [chemical binding]; other site 405534006854 substrate binding site [chemical binding]; other site 405534006855 activation loop (A-loop); other site 405534006856 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 405534006857 SpoOM protein; Region: Spo0M; pfam07070 405534006858 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405534006859 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 405534006860 active site 405534006861 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 405534006862 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 405534006863 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405534006864 catalytic residues [active] 405534006865 Terminase small subunit; Region: Terminase_2; cl01513 405534006866 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 405534006867 CHRD domain; Region: CHRD; pfam07452 405534006868 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 405534006869 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405534006870 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 405534006871 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 405534006872 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 405534006873 C1q domain; Region: C1q; cl17543 405534006874 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 405534006875 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 405534006876 YolD-like protein; Region: YolD; pfam08863 405534006877 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 405534006878 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 405534006879 Transglycosylase; Region: Transgly; pfam00912 405534006880 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 405534006881 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405534006882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534006883 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534006884 putative substrate translocation pore; other site 405534006885 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 405534006886 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 405534006887 dimer interface [polypeptide binding]; other site 405534006888 Citrate synthase; Region: Citrate_synt; pfam00285 405534006889 active site 405534006890 coenzyme A binding site [chemical binding]; other site 405534006891 citrylCoA binding site [chemical binding]; other site 405534006892 oxalacetate/citrate binding site [chemical binding]; other site 405534006893 catalytic triad [active] 405534006894 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 405534006895 2-methylcitrate dehydratase; Region: prpD; TIGR02330 405534006896 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 405534006897 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 405534006898 tetramer interface [polypeptide binding]; other site 405534006899 active site 405534006900 Mg2+/Mn2+ binding site [ion binding]; other site 405534006901 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 405534006902 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405534006903 active site 405534006904 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 405534006905 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405534006906 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 405534006907 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 405534006908 tetrameric interface [polypeptide binding]; other site 405534006909 NAD binding site [chemical binding]; other site 405534006910 catalytic residues [active] 405534006911 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 405534006912 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 405534006913 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405534006914 substrate binding site [chemical binding]; other site 405534006915 oxyanion hole (OAH) forming residues; other site 405534006916 trimer interface [polypeptide binding]; other site 405534006917 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 405534006918 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 405534006919 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 405534006920 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 405534006921 active site 405534006922 metal binding site [ion binding]; metal-binding site 405534006923 DNA binding site [nucleotide binding] 405534006924 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 405534006925 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 405534006926 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 405534006927 Walker A/P-loop; other site 405534006928 ATP binding site [chemical binding]; other site 405534006929 Q-loop/lid; other site 405534006930 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 405534006931 ABC transporter signature motif; other site 405534006932 Walker B; other site 405534006933 D-loop; other site 405534006934 H-loop/switch region; other site 405534006935 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534006936 dimerization interface [polypeptide binding]; other site 405534006937 putative DNA binding site [nucleotide binding]; other site 405534006938 putative Zn2+ binding site [ion binding]; other site 405534006939 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 405534006940 gp32 DNA binding protein like; Region: gp32; cl17537 405534006941 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534006942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534006943 putative substrate translocation pore; other site 405534006944 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 405534006945 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 405534006946 putative NAD(P) binding site [chemical binding]; other site 405534006947 active site 405534006948 isochorismate synthase DhbC; Validated; Region: PRK06923 405534006949 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 405534006950 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 405534006951 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 405534006952 acyl-activating enzyme (AAE) consensus motif; other site 405534006953 active site 405534006954 AMP binding site [chemical binding]; other site 405534006955 substrate binding site [chemical binding]; other site 405534006956 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 405534006957 hydrophobic substrate binding pocket; other site 405534006958 Isochorismatase family; Region: Isochorismatase; pfam00857 405534006959 active site 405534006960 conserved cis-peptide bond; other site 405534006961 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 405534006962 Condensation domain; Region: Condensation; pfam00668 405534006963 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 405534006964 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 405534006965 acyl-activating enzyme (AAE) consensus motif; other site 405534006966 AMP binding site [chemical binding]; other site 405534006967 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405534006968 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 405534006969 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 405534006970 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405534006971 acyl-activating enzyme (AAE) consensus motif; other site 405534006972 AMP binding site [chemical binding]; other site 405534006973 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405534006974 MbtH-like protein; Region: MbtH; cl01279 405534006975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534006976 putative transporter; Provisional; Region: PRK10504 405534006977 putative substrate translocation pore; other site 405534006978 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 405534006979 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 405534006980 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 405534006981 IHF dimer interface [polypeptide binding]; other site 405534006982 IHF - DNA interface [nucleotide binding]; other site 405534006983 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 405534006984 DinB family; Region: DinB; cl17821 405534006985 DinB superfamily; Region: DinB_2; pfam12867 405534006986 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 405534006987 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 405534006988 active site 405534006989 catalytic triad [active] 405534006990 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405534006991 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 405534006992 Glycine riboswitch 405534006993 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 405534006994 metal binding triad [ion binding]; metal-binding site 405534006995 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 405534006996 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 405534006997 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405534006998 RNA binding surface [nucleotide binding]; other site 405534006999 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 405534007000 probable active site [active] 405534007001 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 405534007002 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 405534007003 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 405534007004 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 405534007005 active site 405534007006 dimer interface [polypeptide binding]; other site 405534007007 motif 1; other site 405534007008 motif 2; other site 405534007009 motif 3; other site 405534007010 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 405534007011 anticodon binding site; other site 405534007012 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405534007013 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405534007014 Walker A/P-loop; other site 405534007015 ATP binding site [chemical binding]; other site 405534007016 Q-loop/lid; other site 405534007017 ABC transporter signature motif; other site 405534007018 Walker B; other site 405534007019 D-loop; other site 405534007020 H-loop/switch region; other site 405534007021 FtsX-like permease family; Region: FtsX; pfam02687 405534007022 H+ Antiporter protein; Region: 2A0121; TIGR00900 405534007023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534007024 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405534007025 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405534007026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534007027 dimer interface [polypeptide binding]; other site 405534007028 conserved gate region; other site 405534007029 ABC-ATPase subunit interface; other site 405534007030 pyruvate oxidase; Provisional; Region: PRK08611 405534007031 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 405534007032 PYR/PP interface [polypeptide binding]; other site 405534007033 dimer interface [polypeptide binding]; other site 405534007034 tetramer interface [polypeptide binding]; other site 405534007035 TPP binding site [chemical binding]; other site 405534007036 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405534007037 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 405534007038 TPP-binding site [chemical binding]; other site 405534007039 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 405534007040 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 405534007041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534007042 S-adenosylmethionine binding site [chemical binding]; other site 405534007043 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 405534007044 Protein of unknown function (DUF2185); Region: DUF2185; pfam09951 405534007045 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405534007046 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 405534007047 active site 405534007048 dimerization interface [polypeptide binding]; other site 405534007049 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 405534007050 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 405534007051 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405534007052 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534007053 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534007054 MMPL family; Region: MMPL; pfam03176 405534007055 MMPL family; Region: MMPL; pfam03176 405534007056 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 405534007057 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534007058 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405534007059 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405534007060 Coenzyme A binding pocket [chemical binding]; other site 405534007061 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405534007062 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534007063 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405534007064 Coenzyme A binding pocket [chemical binding]; other site 405534007065 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 405534007066 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 405534007067 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 405534007068 putative acetyltransferase YhhY; Provisional; Region: PRK10140 405534007069 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534007070 Coenzyme A binding pocket [chemical binding]; other site 405534007071 EamA-like transporter family; Region: EamA; pfam00892 405534007072 EamA-like transporter family; Region: EamA; pfam00892 405534007073 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 405534007074 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534007075 non-specific DNA binding site [nucleotide binding]; other site 405534007076 salt bridge; other site 405534007077 sequence-specific DNA binding site [nucleotide binding]; other site 405534007078 Cupin domain; Region: Cupin_2; pfam07883 405534007079 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 405534007080 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405534007081 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405534007082 protoporphyrinogen oxidase; Provisional; Region: PRK12416 405534007083 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405534007084 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405534007085 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405534007086 Cold-inducible protein YdjO; Region: YdjO; pfam14169 405534007087 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405534007088 DNA-binding site [nucleotide binding]; DNA binding site 405534007089 RNA-binding motif; other site 405534007090 CAAX protease self-immunity; Region: Abi; pfam02517 405534007091 AAA domain; Region: AAA_17; pfam13207 405534007092 AAA domain; Region: AAA_18; pfam13238 405534007093 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 405534007094 active site 405534007095 metal binding site [ion binding]; metal-binding site 405534007096 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534007097 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405534007098 active site 405534007099 motif I; other site 405534007100 motif II; other site 405534007101 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534007102 hypothetical protein; Provisional; Region: PRK06770 405534007103 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405534007104 MarR family; Region: MarR_2; cl17246 405534007105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534007106 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 405534007107 putative substrate translocation pore; other site 405534007108 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405534007109 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405534007110 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405534007111 dimerization interface [polypeptide binding]; other site 405534007112 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 405534007113 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 405534007114 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 405534007115 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 405534007116 active site 405534007117 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 405534007118 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 405534007119 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405534007120 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405534007121 dimerization interface [polypeptide binding]; other site 405534007122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 405534007123 MOSC domain; Region: MOSC; pfam03473 405534007124 3-alpha domain; Region: 3-alpha; pfam03475 405534007125 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534007126 Coenzyme A binding pocket [chemical binding]; other site 405534007127 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 405534007128 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405534007129 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405534007130 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534007131 Walker A/P-loop; other site 405534007132 ATP binding site [chemical binding]; other site 405534007133 Q-loop/lid; other site 405534007134 ABC transporter signature motif; other site 405534007135 Walker B; other site 405534007136 D-loop; other site 405534007137 H-loop/switch region; other site 405534007138 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405534007139 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405534007140 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 405534007141 Walker A/P-loop; other site 405534007142 ATP binding site [chemical binding]; other site 405534007143 Q-loop/lid; other site 405534007144 ABC transporter signature motif; other site 405534007145 Walker B; other site 405534007146 D-loop; other site 405534007147 H-loop/switch region; other site 405534007148 LysE type translocator; Region: LysE; cl00565 405534007149 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 405534007150 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534007151 non-specific DNA binding site [nucleotide binding]; other site 405534007152 salt bridge; other site 405534007153 sequence-specific DNA binding site [nucleotide binding]; other site 405534007154 Cupin domain; Region: Cupin_2; pfam07883 405534007155 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 405534007156 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 405534007157 BclB C-terminal domain; Region: exospore_TM; TIGR03721 405534007158 Cupin; Region: Cupin_1; smart00835 405534007159 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 405534007160 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 405534007161 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405534007162 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 405534007163 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405534007164 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 405534007165 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 405534007166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534007167 S-adenosylmethionine binding site [chemical binding]; other site 405534007168 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 405534007169 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 405534007170 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 405534007171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 405534007172 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 405534007173 active site 405534007174 P-loop; other site 405534007175 phosphorylation site [posttranslational modification] 405534007176 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 405534007177 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 405534007178 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 405534007179 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 405534007180 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 405534007181 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 405534007182 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 405534007183 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405534007184 catalytic residue [active] 405534007185 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 405534007186 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 405534007187 tetramer interface [polypeptide binding]; other site 405534007188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534007189 catalytic residue [active] 405534007190 Uncharacterized conserved protein [Function unknown]; Region: COG3339 405534007191 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405534007192 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 405534007193 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 405534007194 ATP binding site [chemical binding]; other site 405534007195 Mg++ binding site [ion binding]; other site 405534007196 motif III; other site 405534007197 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405534007198 nucleotide binding region [chemical binding]; other site 405534007199 ATP-binding site [chemical binding]; other site 405534007200 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534007201 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534007202 H+ Antiporter protein; Region: 2A0121; TIGR00900 405534007203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534007204 putative substrate translocation pore; other site 405534007205 FtsX-like permease family; Region: FtsX; pfam02687 405534007206 FtsX-like permease family; Region: FtsX; pfam02687 405534007207 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405534007208 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405534007209 Walker A/P-loop; other site 405534007210 ATP binding site [chemical binding]; other site 405534007211 Q-loop/lid; other site 405534007212 ABC transporter signature motif; other site 405534007213 Walker B; other site 405534007214 D-loop; other site 405534007215 H-loop/switch region; other site 405534007216 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405534007217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534007218 S-adenosylmethionine binding site [chemical binding]; other site 405534007219 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 405534007220 dimer interface [polypeptide binding]; other site 405534007221 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 405534007222 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 405534007223 dimer interface [polypeptide binding]; other site 405534007224 PYR/PP interface [polypeptide binding]; other site 405534007225 TPP binding site [chemical binding]; other site 405534007226 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405534007227 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 405534007228 TPP-binding site [chemical binding]; other site 405534007229 dimer interface [polypeptide binding]; other site 405534007230 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405534007231 MarR family; Region: MarR_2; pfam12802 405534007232 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405534007233 catalytic core [active] 405534007234 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 405534007235 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 405534007236 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 405534007237 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 405534007238 metal binding site [ion binding]; metal-binding site 405534007239 dimer interface [polypeptide binding]; other site 405534007240 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 405534007241 active site 405534007242 catalytic triad [active] 405534007243 oxyanion hole [active] 405534007244 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 405534007245 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405534007246 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405534007247 DNA binding residues [nucleotide binding] 405534007248 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 405534007249 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405534007250 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405534007251 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405534007252 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405534007253 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405534007254 beta-lactamase TEM; Provisional; Region: PRK15442 405534007255 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 405534007256 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 405534007257 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405534007258 putative active site [active] 405534007259 putative metal binding site [ion binding]; other site 405534007260 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405534007261 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 405534007262 Walker A/P-loop; other site 405534007263 ATP binding site [chemical binding]; other site 405534007264 Q-loop/lid; other site 405534007265 ABC transporter signature motif; other site 405534007266 Walker B; other site 405534007267 D-loop; other site 405534007268 H-loop/switch region; other site 405534007269 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 405534007270 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 405534007271 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534007272 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534007273 Protein of unknown function (DUF523); Region: DUF523; pfam04463 405534007274 Uncharacterized conserved protein [Function unknown]; Region: COG3272 405534007275 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 405534007276 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405534007277 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 405534007278 FAD binding site [chemical binding]; other site 405534007279 homotetramer interface [polypeptide binding]; other site 405534007280 substrate binding pocket [chemical binding]; other site 405534007281 catalytic base [active] 405534007282 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 405534007283 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405534007284 ATP-grasp domain; Region: ATP-grasp_4; cl17255 405534007285 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 405534007286 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 405534007287 carboxyltransferase (CT) interaction site; other site 405534007288 biotinylation site [posttranslational modification]; other site 405534007289 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 405534007290 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 405534007291 active site 405534007292 catalytic residues [active] 405534007293 metal binding site [ion binding]; metal-binding site 405534007294 enoyl-CoA hydratase; Provisional; Region: PRK07657 405534007295 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405534007296 substrate binding site [chemical binding]; other site 405534007297 oxyanion hole (OAH) forming residues; other site 405534007298 trimer interface [polypeptide binding]; other site 405534007299 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 405534007300 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 405534007301 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 405534007302 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 405534007303 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 405534007304 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 405534007305 acyl-activating enzyme (AAE) consensus motif; other site 405534007306 putative AMP binding site [chemical binding]; other site 405534007307 putative active site [active] 405534007308 putative CoA binding site [chemical binding]; other site 405534007309 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405534007310 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534007311 Coenzyme A binding pocket [chemical binding]; other site 405534007312 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 405534007313 hypothetical protein; Provisional; Region: PRK08233 405534007314 active site 405534007315 DinB family; Region: DinB; cl17821 405534007316 DinB superfamily; Region: DinB_2; pfam12867 405534007317 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 405534007318 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405534007319 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534007320 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534007321 dimer interface [polypeptide binding]; other site 405534007322 phosphorylation site [posttranslational modification] 405534007323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534007324 ATP binding site [chemical binding]; other site 405534007325 Mg2+ binding site [ion binding]; other site 405534007326 G-X-G motif; other site 405534007327 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534007328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534007329 active site 405534007330 phosphorylation site [posttranslational modification] 405534007331 intermolecular recognition site; other site 405534007332 dimerization interface [polypeptide binding]; other site 405534007333 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534007334 DNA binding site [nucleotide binding] 405534007335 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405534007336 Zn2+ binding site [ion binding]; other site 405534007337 Mg2+ binding site [ion binding]; other site 405534007338 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 405534007339 S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714 405534007340 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 405534007341 NADH(P)-binding; Region: NAD_binding_10; pfam13460 405534007342 NAD binding site [chemical binding]; other site 405534007343 substrate binding site [chemical binding]; other site 405534007344 putative active site [active] 405534007345 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405534007346 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534007347 Coenzyme A binding pocket [chemical binding]; other site 405534007348 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534007349 Coenzyme A binding pocket [chemical binding]; other site 405534007350 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405534007351 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405534007352 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 405534007353 active site 405534007354 Zn binding site [ion binding]; other site 405534007355 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 405534007356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 405534007357 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 405534007358 putative hydrophobic ligand binding site [chemical binding]; other site 405534007359 Predicted transcriptional regulators [Transcription]; Region: COG1695 405534007360 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405534007361 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405534007362 Beta-lactamase; Region: Beta-lactamase; pfam00144 405534007363 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 405534007364 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405534007365 DNA binding residues [nucleotide binding] 405534007366 drug binding residues [chemical binding]; other site 405534007367 dimer interface [polypeptide binding]; other site 405534007368 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 405534007369 H+ Antiporter protein; Region: 2A0121; TIGR00900 405534007370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534007371 putative substrate translocation pore; other site 405534007372 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405534007373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534007374 S-adenosylmethionine binding site [chemical binding]; other site 405534007375 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 405534007376 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405534007377 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405534007378 active site 405534007379 ATP binding site [chemical binding]; other site 405534007380 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 405534007381 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 405534007382 active site 405534007383 Zn binding site [ion binding]; other site 405534007384 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 405534007385 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405534007386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405534007387 DNA-binding site [nucleotide binding]; DNA binding site 405534007388 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405534007389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534007390 homodimer interface [polypeptide binding]; other site 405534007391 catalytic residue [active] 405534007392 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 405534007393 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 405534007394 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 405534007395 putative NAD(P) binding site [chemical binding]; other site 405534007396 Predicted membrane protein [Function unknown]; Region: COG2323 405534007397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534007398 S-adenosylmethionine binding site [chemical binding]; other site 405534007399 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405534007400 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 405534007401 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 405534007402 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405534007403 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 405534007404 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405534007405 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405534007406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534007407 S-adenosylmethionine binding site [chemical binding]; other site 405534007408 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 405534007409 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 405534007410 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 405534007411 active site 405534007412 HIGH motif; other site 405534007413 KMSKS motif; other site 405534007414 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 405534007415 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 405534007416 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534007417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534007418 active site 405534007419 phosphorylation site [posttranslational modification] 405534007420 intermolecular recognition site; other site 405534007421 dimerization interface [polypeptide binding]; other site 405534007422 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534007423 DNA binding site [nucleotide binding] 405534007424 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534007425 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 405534007426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534007427 ATP binding site [chemical binding]; other site 405534007428 Mg2+ binding site [ion binding]; other site 405534007429 G-X-G motif; other site 405534007430 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405534007431 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405534007432 ABC transporter; Region: ABC_tran_2; pfam12848 405534007433 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405534007434 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405534007435 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405534007436 Walker A/P-loop; other site 405534007437 ATP binding site [chemical binding]; other site 405534007438 Q-loop/lid; other site 405534007439 ABC transporter signature motif; other site 405534007440 Walker B; other site 405534007441 D-loop; other site 405534007442 H-loop/switch region; other site 405534007443 FtsX-like permease family; Region: FtsX; pfam02687 405534007444 hypothetical protein; Provisional; Region: PRK06760 405534007445 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 405534007446 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 405534007447 homoserine dehydrogenase; Validated; Region: PRK06813 405534007448 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 405534007449 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405534007450 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405534007451 DNA-binding site [nucleotide binding]; DNA binding site 405534007452 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405534007453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534007454 homodimer interface [polypeptide binding]; other site 405534007455 catalytic residue [active] 405534007456 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 405534007457 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 405534007458 ATP-grasp domain; Region: ATP-grasp_4; cl17255 405534007459 Putative transcription activator [Transcription]; Region: TenA; COG0819 405534007460 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 405534007461 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 405534007462 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 405534007463 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 405534007464 Uncharacterized conserved protein [Function unknown]; Region: COG5444 405534007465 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 405534007466 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 405534007467 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 405534007468 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105 405534007469 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 405534007470 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 405534007471 Protein of unknown function; Region: DUF3658; pfam12395 405534007472 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 405534007473 Cytochrome P450; Region: p450; cl12078 405534007474 H+ Antiporter protein; Region: 2A0121; TIGR00900 405534007475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534007476 putative substrate translocation pore; other site 405534007477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534007478 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 405534007479 trimer interface [polypeptide binding]; other site 405534007480 active site 405534007481 substrate binding site [chemical binding]; other site 405534007482 CoA binding site [chemical binding]; other site 405534007483 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 405534007484 Predicted transcriptional regulators [Transcription]; Region: COG1695 405534007485 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 405534007486 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534007487 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405534007488 active site 405534007489 motif I; other site 405534007490 motif II; other site 405534007491 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 405534007492 PAS domain S-box; Region: sensory_box; TIGR00229 405534007493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405534007494 putative active site [active] 405534007495 heme pocket [chemical binding]; other site 405534007496 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 405534007497 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534007498 dimer interface [polypeptide binding]; other site 405534007499 phosphorylation site [posttranslational modification] 405534007500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534007501 ATP binding site [chemical binding]; other site 405534007502 Mg2+ binding site [ion binding]; other site 405534007503 G-X-G motif; other site 405534007504 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405534007505 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405534007506 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405534007507 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405534007508 glycosyltransferase, MGT family; Region: MGT; TIGR01426 405534007509 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 405534007510 aspartate racemase; Region: asp_race; TIGR00035 405534007511 hypothetical protein; Provisional; Region: PRK13661 405534007512 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 405534007513 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405534007514 Walker A/P-loop; other site 405534007515 ATP binding site [chemical binding]; other site 405534007516 Q-loop/lid; other site 405534007517 ABC transporter signature motif; other site 405534007518 Walker B; other site 405534007519 D-loop; other site 405534007520 H-loop/switch region; other site 405534007521 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 405534007522 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405534007523 Walker A/P-loop; other site 405534007524 ATP binding site [chemical binding]; other site 405534007525 Q-loop/lid; other site 405534007526 ABC transporter signature motif; other site 405534007527 Walker B; other site 405534007528 D-loop; other site 405534007529 H-loop/switch region; other site 405534007530 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 405534007531 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 405534007532 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534007533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534007534 dimer interface [polypeptide binding]; other site 405534007535 phosphorylation site [posttranslational modification] 405534007536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534007537 ATP binding site [chemical binding]; other site 405534007538 Mg2+ binding site [ion binding]; other site 405534007539 G-X-G motif; other site 405534007540 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 405534007541 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 405534007542 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405534007543 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 405534007544 NAD(P) binding site [chemical binding]; other site 405534007545 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 405534007546 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405534007547 active site 405534007548 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405534007549 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405534007550 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405534007551 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 405534007552 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 405534007553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534007554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534007555 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 405534007556 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 405534007557 classical (c) SDRs; Region: SDR_c; cd05233 405534007558 NAD(P) binding site [chemical binding]; other site 405534007559 active site 405534007560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534007561 H+ Antiporter protein; Region: 2A0121; TIGR00900 405534007562 putative substrate translocation pore; other site 405534007563 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405534007564 Beta-lactamase; Region: Beta-lactamase; pfam00144 405534007565 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 405534007566 EDD domain protein, DegV family; Region: DegV; TIGR00762 405534007567 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 405534007568 Putative amidotransferase; Region: DUF4066; pfam13278 405534007569 conserved cys residue [active] 405534007570 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777 405534007571 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405534007572 DNA binding residues [nucleotide binding] 405534007573 putative dimer interface [polypeptide binding]; other site 405534007574 Trm112p-like protein; Region: Trm112p; pfam03966 405534007575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534007576 S-adenosylmethionine binding site [chemical binding]; other site 405534007577 H+ Antiporter protein; Region: 2A0121; TIGR00900 405534007578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534007579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534007580 Coenzyme A binding pocket [chemical binding]; other site 405534007581 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 405534007582 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 405534007583 active site 405534007584 catalytic site [active] 405534007585 metal binding site [ion binding]; metal-binding site 405534007586 active site 405534007587 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 405534007588 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 405534007589 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405534007590 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405534007591 DNA-binding site [nucleotide binding]; DNA binding site 405534007592 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405534007593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534007594 homodimer interface [polypeptide binding]; other site 405534007595 catalytic residue [active] 405534007596 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405534007597 EamA-like transporter family; Region: EamA; pfam00892 405534007598 EamA-like transporter family; Region: EamA; pfam00892 405534007599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534007600 Coenzyme A binding pocket [chemical binding]; other site 405534007601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 405534007602 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 405534007603 nudix motif; other site 405534007604 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 405534007605 Beta-lactamase; Region: Beta-lactamase; pfam00144 405534007606 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405534007607 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 405534007608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534007609 putative substrate translocation pore; other site 405534007610 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405534007611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534007612 Coenzyme A binding pocket [chemical binding]; other site 405534007613 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405534007614 nudix motif; other site 405534007615 DNA polymerase III subunit beta; Validated; Region: PRK06673 405534007616 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 405534007617 putative DNA binding surface [nucleotide binding]; other site 405534007618 dimer interface [polypeptide binding]; other site 405534007619 beta-clamp/clamp loader binding surface; other site 405534007620 beta-clamp/translesion DNA polymerase binding surface; other site 405534007621 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 405534007622 putative active site [active] 405534007623 nucleotide binding site [chemical binding]; other site 405534007624 nudix motif; other site 405534007625 putative metal binding site [ion binding]; other site 405534007626 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405534007627 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 405534007628 DNA-directed RNA polymerase subunit A''; Provisional; Region: PRK14898 405534007629 translation initiation factor IF-2; Provisional; Region: PRK14845 405534007630 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 405534007631 homotrimer interaction site [polypeptide binding]; other site 405534007632 putative active site [active] 405534007633 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 405534007634 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 405534007635 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 405534007636 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 405534007637 YxiJ-like protein; Region: YxiJ; pfam14176 405534007638 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 405534007639 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 405534007640 active site 405534007641 nucleophile elbow; other site 405534007642 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 405534007643 pentamer interface [polypeptide binding]; other site 405534007644 dodecaamer interface [polypeptide binding]; other site 405534007645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534007646 Coenzyme A binding pocket [chemical binding]; other site 405534007647 metal-dependent hydrolase; Provisional; Region: PRK13291 405534007648 DinB superfamily; Region: DinB_2; pfam12867 405534007649 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405534007650 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405534007651 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 405534007652 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 405534007653 GIY-YIG motif/motif A; other site 405534007654 active site 405534007655 catalytic site [active] 405534007656 putative DNA binding site [nucleotide binding]; other site 405534007657 metal binding site [ion binding]; metal-binding site 405534007658 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405534007659 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405534007660 Coenzyme A binding pocket [chemical binding]; other site 405534007661 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 405534007662 nudix motif; other site 405534007663 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 405534007664 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405534007665 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 405534007666 N-acetyltransferase; Region: Acetyltransf_2; cl00949 405534007667 MepB protein; Region: MepB; pfam08877 405534007668 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 405534007669 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 405534007670 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534007671 motif II; other site 405534007672 DinB superfamily; Region: DinB_2; pfam12867 405534007673 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 405534007674 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405534007675 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 405534007676 active site 405534007677 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 405534007678 carbohydrate binding site [chemical binding]; other site 405534007679 pullulanase, type I; Region: pulA_typeI; TIGR02104 405534007680 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 405534007681 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 405534007682 Ca binding site [ion binding]; other site 405534007683 active site 405534007684 catalytic site [active] 405534007685 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 405534007686 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405534007687 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405534007688 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 405534007689 active site 405534007690 Zn binding site [ion binding]; other site 405534007691 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 405534007692 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405534007693 active site 405534007694 metal binding site [ion binding]; metal-binding site 405534007695 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534007696 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 405534007697 SecY translocase; Region: SecY; pfam00344 405534007698 hypothetical protein; Validated; Region: PRK06672 405534007699 DnaA N-terminal domain; Region: DnaA_N; pfam11638 405534007700 DnaA N-terminal domain; Region: DnaA_N; pfam11638 405534007701 DnaA N-terminal domain; Region: DnaA_N; pfam11638 405534007702 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405534007703 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 405534007704 TAP-like protein; Region: Abhydrolase_4; pfam08386 405534007705 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 405534007706 Mg binding site [ion binding]; other site 405534007707 nucleotide binding site [chemical binding]; other site 405534007708 putative protofilament interface [polypeptide binding]; other site 405534007709 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 405534007710 Predicted membrane protein [Function unknown]; Region: COG4129 405534007711 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 405534007712 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405534007713 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 405534007714 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 405534007715 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 405534007716 germination protein YpeB; Region: spore_YpeB; TIGR02889 405534007717 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 405534007718 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 405534007719 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 405534007720 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 405534007721 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405534007722 Beta-lactamase; Region: Beta-lactamase; pfam00144 405534007723 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 405534007724 arylformamidase; Region: trp_arylform; TIGR03035 405534007725 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 405534007726 kynureninase; Region: kynureninase; TIGR01814 405534007727 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405534007728 catalytic residue [active] 405534007729 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534007730 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534007731 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 405534007732 nudix motif; other site 405534007733 N-acetyltransferase; Region: Acetyltransf_2; cl00949 405534007734 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 405534007735 hydrophobic ligand binding site; other site 405534007736 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 405534007737 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 405534007738 GAF domain; Region: GAF; pfam01590 405534007739 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534007740 Walker A motif; other site 405534007741 ATP binding site [chemical binding]; other site 405534007742 Walker B motif; other site 405534007743 arginine finger; other site 405534007744 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405534007745 NIPSNAP; Region: NIPSNAP; pfam07978 405534007746 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 405534007747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534007748 Coenzyme A binding pocket [chemical binding]; other site 405534007749 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 405534007750 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 405534007751 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405534007752 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 405534007753 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405534007754 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405534007755 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405534007756 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 405534007757 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405534007758 E3 interaction surface; other site 405534007759 lipoyl attachment site [posttranslational modification]; other site 405534007760 e3 binding domain; Region: E3_binding; pfam02817 405534007761 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 405534007762 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 405534007763 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 405534007764 alpha subunit interface [polypeptide binding]; other site 405534007765 TPP binding site [chemical binding]; other site 405534007766 heterodimer interface [polypeptide binding]; other site 405534007767 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405534007768 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 405534007769 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 405534007770 tetramer interface [polypeptide binding]; other site 405534007771 TPP-binding site [chemical binding]; other site 405534007772 heterodimer interface [polypeptide binding]; other site 405534007773 phosphorylation loop region [posttranslational modification] 405534007774 DinB superfamily; Region: DinB_2; pfam12867 405534007775 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 405534007776 short chain dehydrogenase; Provisional; Region: PRK06914 405534007777 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 405534007778 NADP binding site [chemical binding]; other site 405534007779 active site 405534007780 steroid binding site; other site 405534007781 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 405534007782 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 405534007783 active site 405534007784 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 405534007785 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 405534007786 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 405534007787 nudix motif; other site 405534007788 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 405534007789 Protein phosphatase 2C; Region: PP2C_2; pfam13672 405534007790 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 405534007791 nucleotide binding site/active site [active] 405534007792 HIT family signature motif; other site 405534007793 catalytic residue [active] 405534007794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534007795 dimer interface [polypeptide binding]; other site 405534007796 conserved gate region; other site 405534007797 putative PBP binding loops; other site 405534007798 ABC-ATPase subunit interface; other site 405534007799 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 405534007800 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 405534007801 Walker A/P-loop; other site 405534007802 ATP binding site [chemical binding]; other site 405534007803 Q-loop/lid; other site 405534007804 ABC transporter signature motif; other site 405534007805 Walker B; other site 405534007806 D-loop; other site 405534007807 H-loop/switch region; other site 405534007808 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 405534007809 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 405534007810 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 405534007811 Clp protease; Region: CLP_protease; pfam00574 405534007812 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 405534007813 oligomer interface [polypeptide binding]; other site 405534007814 active site residues [active] 405534007815 RNA polymerase factor sigma-70; Validated; Region: PRK06704 405534007816 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405534007817 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 405534007818 DNA binding residues [nucleotide binding] 405534007819 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 405534007820 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 405534007821 catalytic loop [active] 405534007822 iron binding site [ion binding]; other site 405534007823 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 405534007824 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405534007825 active site 405534007826 dimer interface [polypeptide binding]; other site 405534007827 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534007828 Coenzyme A binding pocket [chemical binding]; other site 405534007829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 405534007830 Chitin binding domain; Region: Chitin_bind_3; pfam03067 405534007831 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405534007832 Interdomain contacts; other site 405534007833 Cytokine receptor motif; other site 405534007834 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405534007835 Interdomain contacts; other site 405534007836 Cytokine receptor motif; other site 405534007837 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 405534007838 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 405534007839 glycosyltransferase, MGT family; Region: MGT; TIGR01426 405534007840 active site 405534007841 TDP-binding site; other site 405534007842 acceptor substrate-binding pocket; other site 405534007843 homodimer interface [polypeptide binding]; other site 405534007844 Uncharacterized conserved protein [Function unknown]; Region: COG1262 405534007845 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 405534007846 topology modulation protein; Reviewed; Region: PRK08118 405534007847 AAA domain; Region: AAA_17; pfam13207 405534007848 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 405534007849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534007850 S-adenosylmethionine binding site [chemical binding]; other site 405534007851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 405534007852 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534007853 Coenzyme A binding pocket [chemical binding]; other site 405534007854 S-layer homology domain; Region: SLH; pfam00395 405534007855 S-layer homology domain; Region: SLH; pfam00395 405534007856 S-layer homology domain; Region: SLH; pfam00395 405534007857 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 405534007858 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405534007859 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 405534007860 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534007861 Coenzyme A binding pocket [chemical binding]; other site 405534007862 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 405534007863 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534007864 Coenzyme A binding pocket [chemical binding]; other site 405534007865 Predicted transcriptional regulators [Transcription]; Region: COG1695 405534007866 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405534007867 Protein of unknown function (DUF952); Region: DUF952; pfam06108 405534007868 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 405534007869 Part of AAA domain; Region: AAA_19; pfam13245 405534007870 Family description; Region: UvrD_C_2; pfam13538 405534007871 CAAX protease self-immunity; Region: Abi; pfam02517 405534007872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534007873 S-adenosylmethionine binding site [chemical binding]; other site 405534007874 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 405534007875 putative active site pocket [active] 405534007876 dimerization interface [polypeptide binding]; other site 405534007877 putative catalytic residue [active] 405534007878 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 405534007879 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405534007880 ATP binding site [chemical binding]; other site 405534007881 putative Mg++ binding site [ion binding]; other site 405534007882 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405534007883 nucleotide binding region [chemical binding]; other site 405534007884 ATP-binding site [chemical binding]; other site 405534007885 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 405534007886 HRDC domain; Region: HRDC; pfam00570 405534007887 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 405534007888 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 405534007889 active site 405534007890 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 405534007891 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405534007892 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 405534007893 active site 405534007894 metal binding site [ion binding]; metal-binding site 405534007895 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 405534007896 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 405534007897 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 405534007898 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 405534007899 active site 405534007900 Zn binding site [ion binding]; other site 405534007901 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 405534007902 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 405534007903 DHHA2 domain; Region: DHHA2; pfam02833 405534007904 Chitin binding domain; Region: Chitin_bind_3; pfam03067 405534007905 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405534007906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534007907 Coenzyme A binding pocket [chemical binding]; other site 405534007908 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405534007909 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405534007910 Zn2+ binding site [ion binding]; other site 405534007911 Mg2+ binding site [ion binding]; other site 405534007912 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 405534007913 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405534007914 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 405534007915 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 405534007916 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 405534007917 NAD(P) binding site [chemical binding]; other site 405534007918 catalytic residues [active] 405534007919 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 405534007920 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 405534007921 inhibitor site; inhibition site 405534007922 active site 405534007923 dimer interface [polypeptide binding]; other site 405534007924 catalytic residue [active] 405534007925 Proline racemase; Region: Pro_racemase; pfam05544 405534007926 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 405534007927 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 405534007928 Proline racemase; Region: Pro_racemase; pfam05544 405534007929 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 405534007930 hydroxyglutarate oxidase; Provisional; Region: PRK11728 405534007931 PAS domain; Region: PAS; smart00091 405534007932 PAS domain; Region: PAS_9; pfam13426 405534007933 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534007934 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 405534007935 Walker A motif; other site 405534007936 ATP binding site [chemical binding]; other site 405534007937 Walker B motif; other site 405534007938 arginine finger; other site 405534007939 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405534007940 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 405534007941 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534007942 Walker A/P-loop; other site 405534007943 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 405534007944 catalytic loop [active] 405534007945 iron binding site [ion binding]; other site 405534007946 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 405534007947 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405534007948 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 405534007949 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 405534007950 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 405534007951 DltD N-terminal region; Region: DltD_N; pfam04915 405534007952 DltD central region; Region: DltD_M; pfam04918 405534007953 DltD C-terminal region; Region: DltD_C; pfam04914 405534007954 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405534007955 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534007956 Coenzyme A binding pocket [chemical binding]; other site 405534007957 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405534007958 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405534007959 peptide binding site [polypeptide binding]; other site 405534007960 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405534007961 NlpC/P60 family; Region: NLPC_P60; pfam00877 405534007962 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 405534007963 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 405534007964 active site 405534007965 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 405534007966 Septum formation initiator; Region: DivIC; pfam04977 405534007967 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 405534007968 DJ-1 family protein; Region: not_thiJ; TIGR01383 405534007969 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 405534007970 conserved cys residue [active] 405534007971 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 405534007972 active site 405534007973 catalytic motif [active] 405534007974 Zn binding site [ion binding]; other site 405534007975 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405534007976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534007977 S-adenosylmethionine binding site [chemical binding]; other site 405534007978 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 405534007979 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 405534007980 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534007981 dimerization interface [polypeptide binding]; other site 405534007982 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534007983 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534007984 dimer interface [polypeptide binding]; other site 405534007985 phosphorylation site [posttranslational modification] 405534007986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534007987 ATP binding site [chemical binding]; other site 405534007988 Mg2+ binding site [ion binding]; other site 405534007989 G-X-G motif; other site 405534007990 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534007991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534007992 active site 405534007993 phosphorylation site [posttranslational modification] 405534007994 intermolecular recognition site; other site 405534007995 dimerization interface [polypeptide binding]; other site 405534007996 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534007997 DNA binding site [nucleotide binding] 405534007998 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405534007999 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 405534008000 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534008001 motif II; other site 405534008002 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Provisional; Region: PRK14697 405534008003 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 405534008004 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 405534008005 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 405534008006 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 405534008007 Zn binding site [ion binding]; other site 405534008008 EDD domain protein, DegV family; Region: DegV; TIGR00762 405534008009 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 405534008010 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 405534008011 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 405534008012 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 405534008013 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534008014 Coenzyme A binding pocket [chemical binding]; other site 405534008015 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 405534008016 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405534008017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534008018 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534008019 putative substrate translocation pore; other site 405534008020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534008021 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 405534008022 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 405534008023 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 405534008024 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 405534008025 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 405534008026 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 405534008027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534008028 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534008029 putative substrate translocation pore; other site 405534008030 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 405534008031 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 405534008032 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 405534008033 active site 405534008034 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 405534008035 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405534008036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534008037 S-adenosylmethionine binding site [chemical binding]; other site 405534008038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534008039 putative substrate translocation pore; other site 405534008040 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534008041 aspartate aminotransferase; Provisional; Region: PRK07681 405534008042 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405534008043 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534008044 homodimer interface [polypeptide binding]; other site 405534008045 catalytic residue [active] 405534008046 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 405534008047 pantothenate kinase; Provisional; Region: PRK13317 405534008048 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 405534008049 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 405534008050 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 405534008051 Protein of unknown function (DUF4052); Region: DUF4052; pfam13261 405534008052 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 405534008053 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 405534008054 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 405534008055 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 405534008056 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 405534008057 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 405534008058 Domain of unknown function DUF20; Region: UPF0118; pfam01594 405534008059 HNH endonuclease; Region: HNH_5; pfam14279 405534008060 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 405534008061 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 405534008062 active site 405534008063 dimer interface [polypeptide binding]; other site 405534008064 non-prolyl cis peptide bond; other site 405534008065 insertion regions; other site 405534008066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 405534008067 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405534008068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 405534008069 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 405534008070 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405534008071 substrate binding pocket [chemical binding]; other site 405534008072 membrane-bound complex binding site; other site 405534008073 hinge residues; other site 405534008074 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 405534008075 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 405534008076 Walker A/P-loop; other site 405534008077 ATP binding site [chemical binding]; other site 405534008078 Q-loop/lid; other site 405534008079 ABC transporter signature motif; other site 405534008080 Walker B; other site 405534008081 D-loop; other site 405534008082 H-loop/switch region; other site 405534008083 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534008084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534008085 Protein of unknown function (DUF402); Region: DUF402; pfam04167 405534008086 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 405534008087 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 405534008088 binding surface 405534008089 TPR motif; other site 405534008090 hypothetical protein; Provisional; Region: PRK09620 405534008091 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 405534008092 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 405534008093 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 405534008094 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405534008095 Coenzyme A binding pocket [chemical binding]; other site 405534008096 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 405534008097 Protein of unknown function (DUF664); Region: DUF664; pfam04978 405534008098 DinB superfamily; Region: DinB_2; pfam12867 405534008099 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 405534008100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534008101 Coenzyme A binding pocket [chemical binding]; other site 405534008102 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405534008103 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405534008104 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 405534008105 active site 405534008106 NTP binding site [chemical binding]; other site 405534008107 metal binding triad [ion binding]; metal-binding site 405534008108 antibiotic binding site [chemical binding]; other site 405534008109 A new structural DNA glycosylase; Region: AlkD_like; cd06561 405534008110 active site 405534008111 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534008112 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405534008113 active site 405534008114 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 405534008115 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 405534008116 NodB motif; other site 405534008117 active site 405534008118 catalytic site [active] 405534008119 Zn binding site [ion binding]; other site 405534008120 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 405534008121 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 405534008122 Sulfatase; Region: Sulfatase; pfam00884 405534008123 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 405534008124 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405534008125 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405534008126 ABC transporter; Region: ABC_tran_2; pfam12848 405534008127 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405534008128 hypothetical protein; Provisional; Region: PRK06761 405534008129 MMPL family; Region: MMPL; pfam03176 405534008130 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 405534008131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534008132 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534008133 Sterol carrier protein domain; Region: SCP2_2; pfam13530 405534008134 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 405534008135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534008136 Coenzyme A binding pocket [chemical binding]; other site 405534008137 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 405534008138 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 405534008139 hinge; other site 405534008140 active site 405534008141 prephenate dehydrogenase; Validated; Region: PRK06545 405534008142 prephenate dehydrogenase; Validated; Region: PRK08507 405534008143 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 405534008144 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 405534008145 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405534008146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534008147 homodimer interface [polypeptide binding]; other site 405534008148 catalytic residue [active] 405534008149 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 405534008150 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 405534008151 Tetramer interface [polypeptide binding]; other site 405534008152 active site 405534008153 FMN-binding site [chemical binding]; other site 405534008154 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 405534008155 Chorismate mutase type II; Region: CM_2; cl00693 405534008156 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 405534008157 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 405534008158 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 405534008159 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 405534008160 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405534008161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534008162 Coenzyme A binding pocket [chemical binding]; other site 405534008163 Isochorismatase family; Region: Isochorismatase; pfam00857 405534008164 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 405534008165 catalytic triad [active] 405534008166 conserved cis-peptide bond; other site 405534008167 YfzA-like protein; Region: YfzA; pfam14118 405534008168 Bacterial SH3 domain; Region: SH3_3; pfam08239 405534008169 Bacterial SH3 domain; Region: SH3_3; pfam08239 405534008170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 405534008171 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 405534008172 malate:quinone oxidoreductase; Validated; Region: PRK05257 405534008173 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 405534008174 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 405534008175 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 405534008176 ligand binding site [chemical binding]; other site 405534008177 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405534008178 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405534008179 TM-ABC transporter signature motif; other site 405534008180 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405534008181 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405534008182 TM-ABC transporter signature motif; other site 405534008183 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 405534008184 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 405534008185 Walker A/P-loop; other site 405534008186 ATP binding site [chemical binding]; other site 405534008187 Q-loop/lid; other site 405534008188 ABC transporter signature motif; other site 405534008189 Walker B; other site 405534008190 D-loop; other site 405534008191 H-loop/switch region; other site 405534008192 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405534008193 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 405534008194 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 405534008195 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 405534008196 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 405534008197 putative N- and C-terminal domain interface [polypeptide binding]; other site 405534008198 putative active site [active] 405534008199 putative MgATP binding site [chemical binding]; other site 405534008200 catalytic site [active] 405534008201 metal binding site [ion binding]; metal-binding site 405534008202 putative carbohydrate binding site [chemical binding]; other site 405534008203 Cupin domain; Region: Cupin_2; pfam07883 405534008204 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 405534008205 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 405534008206 putative active site; other site 405534008207 catalytic residue [active] 405534008208 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 405534008209 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 405534008210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534008211 H+ Antiporter protein; Region: 2A0121; TIGR00900 405534008212 putative substrate translocation pore; other site 405534008213 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534008214 putative DNA binding site [nucleotide binding]; other site 405534008215 putative Zn2+ binding site [ion binding]; other site 405534008216 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405534008217 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405534008218 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405534008219 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 405534008220 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 405534008221 putative catalytic cysteine [active] 405534008222 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 405534008223 gamma-glutamyl kinase; Provisional; Region: PRK05429 405534008224 homotetrameric interface [polypeptide binding]; other site 405534008225 putative phosphate binding site [ion binding]; other site 405534008226 putative allosteric binding site; other site 405534008227 nucleotide binding site [chemical binding]; other site 405534008228 PUA domain; Region: PUA; pfam01472 405534008229 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 405534008230 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 405534008231 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 405534008232 putative metal binding site [ion binding]; other site 405534008233 putative dimer interface [polypeptide binding]; other site 405534008234 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 405534008235 Transcriptional regulator [Transcription]; Region: IclR; COG1414 405534008236 Bacterial transcriptional regulator; Region: IclR; pfam01614 405534008237 S-methylmethionine transporter; Provisional; Region: PRK11387 405534008238 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 405534008239 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 405534008240 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 405534008241 putative di-iron ligands [ion binding]; other site 405534008242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 405534008243 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 405534008244 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 405534008245 dimer interface [polypeptide binding]; other site 405534008246 Alkaline phosphatase homologues; Region: alkPPc; smart00098 405534008247 active site 405534008248 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 405534008249 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534008250 salt bridge; other site 405534008251 non-specific DNA binding site [nucleotide binding]; other site 405534008252 sequence-specific DNA binding site [nucleotide binding]; other site 405534008253 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 405534008254 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 405534008255 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 405534008256 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 405534008257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 405534008258 active site 405534008259 phosphorylation site [posttranslational modification] 405534008260 intermolecular recognition site; other site 405534008261 LytTr DNA-binding domain; Region: LytTR; pfam04397 405534008262 uridine kinase; Provisional; Region: PRK07667 405534008263 active site 405534008264 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405534008265 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534008266 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405534008267 Coenzyme A binding pocket [chemical binding]; other site 405534008268 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534008269 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405534008270 active site 405534008271 metal binding site [ion binding]; metal-binding site 405534008272 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 405534008273 Predicted transcriptional regulators [Transcription]; Region: COG1695 405534008274 Transcriptional regulator PadR-like family; Region: PadR; cl17335 405534008275 MoxR-like ATPases [General function prediction only]; Region: COG0714 405534008276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534008277 Walker A motif; other site 405534008278 ATP binding site [chemical binding]; other site 405534008279 Walker B motif; other site 405534008280 arginine finger; other site 405534008281 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 405534008282 Protein of unknown function DUF58; Region: DUF58; pfam01882 405534008283 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 405534008284 proline/glycine betaine transporter; Provisional; Region: PRK10642 405534008285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534008286 putative substrate translocation pore; other site 405534008287 acetylornithine aminotransferase; Provisional; Region: PRK02627 405534008288 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405534008289 inhibitor-cofactor binding pocket; inhibition site 405534008290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534008291 catalytic residue [active] 405534008292 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 405534008293 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 405534008294 tetramer interface [polypeptide binding]; other site 405534008295 heme binding pocket [chemical binding]; other site 405534008296 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 405534008297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534008298 dimer interface [polypeptide binding]; other site 405534008299 conserved gate region; other site 405534008300 putative PBP binding loops; other site 405534008301 ABC-ATPase subunit interface; other site 405534008302 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 405534008303 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 405534008304 Walker A/P-loop; other site 405534008305 ATP binding site [chemical binding]; other site 405534008306 Q-loop/lid; other site 405534008307 ABC transporter signature motif; other site 405534008308 Walker B; other site 405534008309 D-loop; other site 405534008310 H-loop/switch region; other site 405534008311 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 405534008312 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405534008313 membrane-bound complex binding site; other site 405534008314 hinge residues; other site 405534008315 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 405534008316 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405534008317 MarR family; Region: MarR_2; pfam12802 405534008318 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 405534008319 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 405534008320 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 405534008321 active site 405534008322 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 405534008323 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405534008324 Beta-lactamase; Region: Beta-lactamase; pfam00144 405534008325 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 405534008326 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 405534008327 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 405534008328 Protein of unknown function DUF58; Region: DUF58; pfam01882 405534008329 MoxR-like ATPases [General function prediction only]; Region: COG0714 405534008330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534008331 Walker A motif; other site 405534008332 ATP binding site [chemical binding]; other site 405534008333 Walker B motif; other site 405534008334 arginine finger; other site 405534008335 Uncharacterized conserved protein [Function unknown]; Region: COG1359 405534008336 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 405534008337 dimer interface [polypeptide binding]; other site 405534008338 FMN binding site [chemical binding]; other site 405534008339 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405534008340 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534008341 putative DNA binding site [nucleotide binding]; other site 405534008342 putative Zn2+ binding site [ion binding]; other site 405534008343 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 405534008344 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 405534008345 G1 box; other site 405534008346 putative GEF interaction site [polypeptide binding]; other site 405534008347 GTP/Mg2+ binding site [chemical binding]; other site 405534008348 Switch I region; other site 405534008349 G2 box; other site 405534008350 G3 box; other site 405534008351 Switch II region; other site 405534008352 G4 box; other site 405534008353 G5 box; other site 405534008354 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 405534008355 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 405534008356 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 405534008357 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 405534008358 nudix motif; other site 405534008359 YfzA-like protein; Region: YfzA; pfam14118 405534008360 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 405534008361 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405534008362 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405534008363 Walker A/P-loop; other site 405534008364 ATP binding site [chemical binding]; other site 405534008365 Q-loop/lid; other site 405534008366 ABC transporter signature motif; other site 405534008367 Walker B; other site 405534008368 D-loop; other site 405534008369 H-loop/switch region; other site 405534008370 Predicted transcriptional regulators [Transcription]; Region: COG1725 405534008371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405534008372 DNA-binding site [nucleotide binding]; DNA binding site 405534008373 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 405534008374 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 405534008375 putative NAD(P) binding site [chemical binding]; other site 405534008376 active site 405534008377 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405534008378 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405534008379 Walker A/P-loop; other site 405534008380 ATP binding site [chemical binding]; other site 405534008381 Q-loop/lid; other site 405534008382 ABC transporter signature motif; other site 405534008383 Walker B; other site 405534008384 D-loop; other site 405534008385 H-loop/switch region; other site 405534008386 FtsX-like permease family; Region: FtsX; pfam02687 405534008387 FtsX-like permease family; Region: FtsX; pfam02687 405534008388 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405534008389 Beta-lactamase; Region: Beta-lactamase; pfam00144 405534008390 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405534008391 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405534008392 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 405534008393 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405534008394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534008395 Coenzyme A binding pocket [chemical binding]; other site 405534008396 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 405534008397 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 405534008398 nudix motif; other site 405534008399 EamA-like transporter family; Region: EamA; pfam00892 405534008400 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405534008401 EamA-like transporter family; Region: EamA; pfam00892 405534008402 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405534008403 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405534008404 DNA-binding site [nucleotide binding]; DNA binding site 405534008405 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405534008406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534008407 homodimer interface [polypeptide binding]; other site 405534008408 catalytic residue [active] 405534008409 hypothetical protein; Validated; Region: PRK00124 405534008410 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 405534008411 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 405534008412 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 405534008413 active site 405534008414 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 405534008415 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405534008416 active site 405534008417 metal binding site [ion binding]; metal-binding site 405534008418 Phosphotransferase enzyme family; Region: APH; pfam01636 405534008419 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405534008420 active site 405534008421 substrate binding site [chemical binding]; other site 405534008422 ATP binding site [chemical binding]; other site 405534008423 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 405534008424 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405534008425 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405534008426 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534008427 Coenzyme A binding pocket [chemical binding]; other site 405534008428 Lysine riboswitch 405534008429 lysine transporter; Provisional; Region: PRK10836 405534008430 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 405534008431 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 405534008432 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405534008433 DNA binding residues [nucleotide binding] 405534008434 dimer interface [polypeptide binding]; other site 405534008435 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 405534008436 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 405534008437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534008438 S-adenosylmethionine binding site [chemical binding]; other site 405534008439 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 405534008440 FIC domain binding interface [polypeptide binding]; other site 405534008441 Cache domain; Region: Cache_2; cl07034 405534008442 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 405534008443 putative active site [active] 405534008444 nucleotide binding site [chemical binding]; other site 405534008445 nudix motif; other site 405534008446 putative metal binding site [ion binding]; other site 405534008447 Cephalosporin hydroxylase; Region: CmcI; pfam04989 405534008448 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405534008449 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405534008450 Catalytic site [active] 405534008451 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405534008452 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405534008453 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405534008454 NAD-dependent deacetylase; Provisional; Region: PRK00481 405534008455 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 405534008456 NAD+ binding site [chemical binding]; other site 405534008457 substrate binding site [chemical binding]; other site 405534008458 Zn binding site [ion binding]; other site 405534008459 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 405534008460 putative substrate binding pocket [chemical binding]; other site 405534008461 AC domain interface; other site 405534008462 catalytic triad [active] 405534008463 AB domain interface; other site 405534008464 interchain disulfide; other site 405534008465 Predicted membrane protein [Function unknown]; Region: COG3817 405534008466 Protein of unknown function (DUF979); Region: DUF979; pfam06166 405534008467 Protein of unknown function (DUF969); Region: DUF969; pfam06149 405534008468 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 405534008469 putative active site [active] 405534008470 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 405534008471 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 405534008472 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 405534008473 Transcriptional regulator [Transcription]; Region: IclR; COG1414 405534008474 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 405534008475 Bacterial transcriptional regulator; Region: IclR; pfam01614 405534008476 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405534008477 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405534008478 Catalytic site [active] 405534008479 CutC family; Region: CutC; cl01218 405534008480 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 405534008481 stage II sporulation protein P; Region: spore_II_P; TIGR02867 405534008482 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534008483 dimerization interface [polypeptide binding]; other site 405534008484 putative DNA binding site [nucleotide binding]; other site 405534008485 putative Zn2+ binding site [ion binding]; other site 405534008486 DinB superfamily; Region: DinB_2; pfam12867 405534008487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534008488 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534008489 putative substrate translocation pore; other site 405534008490 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405534008491 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 405534008492 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 405534008493 Uncharacterized conserved protein [Function unknown]; Region: COG1434 405534008494 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 405534008495 putative active site [active] 405534008496 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405534008497 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405534008498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 405534008499 Nucleoside recognition; Region: Gate; pfam07670 405534008500 S-layer homology domain; Region: SLH; pfam00395 405534008501 S-layer homology domain; Region: SLH; pfam00395 405534008502 S-layer homology domain; Region: SLH; pfam00395 405534008503 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 405534008504 putative active site [active] 405534008505 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405534008506 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534008507 Coenzyme A binding pocket [chemical binding]; other site 405534008508 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 405534008509 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 405534008510 Ferritin-like domain; Region: Ferritin; pfam00210 405534008511 dinuclear metal binding motif [ion binding]; other site 405534008512 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 405534008513 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 405534008514 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534008515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534008516 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 405534008517 phosphoenolpyruvate synthase; Validated; Region: PRK06241 405534008518 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 405534008519 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 405534008520 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 405534008521 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405534008522 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 405534008523 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 405534008524 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 405534008525 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 405534008526 LysE type translocator; Region: LysE; pfam01810 405534008527 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 405534008528 Spore germination protein; Region: Spore_permease; cl17796 405534008529 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405534008530 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 405534008531 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 405534008532 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405534008533 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 405534008534 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 405534008535 NAD binding site [chemical binding]; other site 405534008536 catalytic Zn binding site [ion binding]; other site 405534008537 structural Zn binding site [ion binding]; other site 405534008538 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 405534008539 Mn-containing catalase [Inorganic ion transport and metabolism]; Region: COG3546 405534008540 dinuclear metal binding motif [ion binding]; other site 405534008541 aspartate ammonia-lyase; Provisional; Region: PRK14515 405534008542 Aspartase; Region: Aspartase; cd01357 405534008543 active sites [active] 405534008544 tetramer interface [polypeptide binding]; other site 405534008545 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 405534008546 active site 405534008547 homodimer interface [polypeptide binding]; other site 405534008548 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405534008549 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534008550 non-specific DNA binding site [nucleotide binding]; other site 405534008551 salt bridge; other site 405534008552 sequence-specific DNA binding site [nucleotide binding]; other site 405534008553 Integrase core domain; Region: rve_3; cl15866 405534008554 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 405534008555 GIY-YIG motif/motif A; other site 405534008556 active site 405534008557 catalytic site [active] 405534008558 putative DNA binding site [nucleotide binding]; other site 405534008559 metal binding site [ion binding]; metal-binding site 405534008560 amino acid transporter; Region: 2A0306; TIGR00909 405534008561 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 405534008562 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 405534008563 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 405534008564 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405534008565 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405534008566 Spore germination protein; Region: Spore_permease; pfam03845 405534008567 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405534008568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534008569 Response regulator receiver domain; Region: Response_reg; pfam00072 405534008570 active site 405534008571 phosphorylation site [posttranslational modification] 405534008572 intermolecular recognition site; other site 405534008573 dimerization interface [polypeptide binding]; other site 405534008574 YcbB domain; Region: YcbB; pfam08664 405534008575 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534008576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534008577 ATP binding site [chemical binding]; other site 405534008578 Mg2+ binding site [ion binding]; other site 405534008579 G-X-G motif; other site 405534008580 glutaminase; Reviewed; Region: PRK12357 405534008581 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 405534008582 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405534008583 amino acid carrier protein; Region: agcS; TIGR00835 405534008584 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 405534008585 transmembrane helices; other site 405534008586 Cytochrome P450; Region: p450; cl12078 405534008587 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405534008588 Beta-lactamase; Region: Beta-lactamase; pfam00144 405534008589 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 405534008590 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 405534008591 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 405534008592 [2Fe-2S] cluster binding site [ion binding]; other site 405534008593 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 405534008594 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 405534008595 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 405534008596 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 405534008597 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 405534008598 putative active site [active] 405534008599 putative metal binding site [ion binding]; other site 405534008600 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405534008601 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 405534008602 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 405534008603 tetramer interface [polypeptide binding]; other site 405534008604 heme binding pocket [chemical binding]; other site 405534008605 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 405534008606 Cl binding site [ion binding]; other site 405534008607 oligomer interface [polypeptide binding]; other site 405534008608 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 405534008609 plasmid segregation protein ParM; Provisional; Region: PRK13917 405534008610 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 405534008611 Mg binding site [ion binding]; other site 405534008612 nucleotide binding site [chemical binding]; other site 405534008613 putative protofilament interface [polypeptide binding]; other site 405534008614 Heat induced stress protein YflT; Region: YflT; pfam11181 405534008615 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405534008616 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405534008617 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 405534008618 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 405534008619 TspO/MBR family; Region: TspO_MBR; pfam03073 405534008620 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 405534008621 DNA photolyase; Region: DNA_photolyase; pfam00875 405534008622 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 405534008623 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 405534008624 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 405534008625 active site clefts [active] 405534008626 Carbonic anhydrase; Region: Pro_CA; pfam00484 405534008627 zinc binding site [ion binding]; other site 405534008628 dimer interface [polypeptide binding]; other site 405534008629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 405534008630 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 405534008631 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 405534008632 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 405534008633 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 405534008634 Spore germination protein; Region: Spore_permease; cl17796 405534008635 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405534008636 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405534008637 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405534008638 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405534008639 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534008640 Coenzyme A binding pocket [chemical binding]; other site 405534008641 Homeodomain-like domain; Region: HTH_23; pfam13384 405534008642 putative transposase OrfB; Reviewed; Region: PHA02517 405534008643 HTH-like domain; Region: HTH_21; pfam13276 405534008644 Integrase core domain; Region: rve; pfam00665 405534008645 Integrase core domain; Region: rve_2; pfam13333 405534008646 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 405534008647 UbiA prenyltransferase family; Region: UbiA; pfam01040 405534008648 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 405534008649 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 405534008650 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 405534008651 Phosphotransferase enzyme family; Region: APH; pfam01636 405534008652 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405534008653 active site 405534008654 ATP binding site [chemical binding]; other site 405534008655 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 405534008656 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 405534008657 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 405534008658 short chain dehydrogenase; Validated; Region: PRK08324 405534008659 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 405534008660 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 405534008661 putative NAD(P) binding site [chemical binding]; other site 405534008662 active site 405534008663 L-fucose isomerase; Provisional; Region: fucI; PRK10991 405534008664 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 405534008665 hexamer (dimer of trimers) interface [polypeptide binding]; other site 405534008666 trimer interface [polypeptide binding]; other site 405534008667 substrate binding site [chemical binding]; other site 405534008668 Mn binding site [ion binding]; other site 405534008669 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 405534008670 N- and C-terminal domain interface [polypeptide binding]; other site 405534008671 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 405534008672 active site 405534008673 putative catalytic site [active] 405534008674 metal binding site [ion binding]; metal-binding site 405534008675 ATP binding site [chemical binding]; other site 405534008676 carbohydrate binding site [chemical binding]; other site 405534008677 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 405534008678 intersubunit interface [polypeptide binding]; other site 405534008679 active site 405534008680 Zn2+ binding site [ion binding]; other site 405534008681 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 405534008682 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 405534008683 putative ligand binding site [chemical binding]; other site 405534008684 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405534008685 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405534008686 TM-ABC transporter signature motif; other site 405534008687 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 405534008688 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 405534008689 Walker A/P-loop; other site 405534008690 ATP binding site [chemical binding]; other site 405534008691 Q-loop/lid; other site 405534008692 ABC transporter signature motif; other site 405534008693 Walker B; other site 405534008694 D-loop; other site 405534008695 H-loop/switch region; other site 405534008696 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405534008697 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 405534008698 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405534008699 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405534008700 DNA binding site [nucleotide binding] 405534008701 domain linker motif; other site 405534008702 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 405534008703 dimerization interface [polypeptide binding]; other site 405534008704 ligand binding site [chemical binding]; other site 405534008705 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 405534008706 Low molecular weight phosphatase family; Region: LMWPc; cd00115 405534008707 active site 405534008708 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 405534008709 arsenical-resistance protein; Region: acr3; TIGR00832 405534008710 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534008711 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 405534008712 putative metal binding site [ion binding]; other site 405534008713 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534008714 dimerization interface [polypeptide binding]; other site 405534008715 putative DNA binding site [nucleotide binding]; other site 405534008716 putative Zn2+ binding site [ion binding]; other site 405534008717 DinB superfamily; Region: DinB_2; pfam12867 405534008718 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 405534008719 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 405534008720 RibD C-terminal domain; Region: RibD_C; cl17279 405534008721 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 405534008722 FtsX-like permease family; Region: FtsX; pfam02687 405534008723 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 405534008724 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405534008725 FtsX-like permease family; Region: FtsX; pfam02687 405534008726 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405534008727 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405534008728 Q-loop/lid; other site 405534008729 ABC transporter signature motif; other site 405534008730 Walker B; other site 405534008731 D-loop; other site 405534008732 H-loop/switch region; other site 405534008733 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 405534008734 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 405534008735 active site 405534008736 NTP binding site [chemical binding]; other site 405534008737 metal binding triad [ion binding]; metal-binding site 405534008738 antibiotic binding site [chemical binding]; other site 405534008739 HEPN domain; Region: HEPN; cl00824 405534008740 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405534008741 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 405534008742 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 405534008743 putative NAD(P) binding site [chemical binding]; other site 405534008744 active site 405534008745 putative substrate binding site [chemical binding]; other site 405534008746 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405534008747 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534008748 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534008749 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 405534008750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534008751 putative substrate translocation pore; other site 405534008752 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534008753 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534008754 short chain dehydrogenase; Provisional; Region: PRK12746 405534008755 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 405534008756 NADP binding site [chemical binding]; other site 405534008757 homodimer interface [polypeptide binding]; other site 405534008758 active site 405534008759 substrate binding site [chemical binding]; other site 405534008760 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 405534008761 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534008762 putative DNA binding site [nucleotide binding]; other site 405534008763 putative Zn2+ binding site [ion binding]; other site 405534008764 AsnC family; Region: AsnC_trans_reg; pfam01037 405534008765 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405534008766 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 405534008767 metal binding site [ion binding]; metal-binding site 405534008768 AAA domain; Region: AAA_11; pfam13086 405534008769 Part of AAA domain; Region: AAA_19; pfam13245 405534008770 Erp protein C-terminus; Region: Erp_C; pfam06780 405534008771 AAA domain; Region: AAA_30; pfam13604 405534008772 AAA domain; Region: AAA_12; pfam13087 405534008773 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 405534008774 putative active site [active] 405534008775 catalytic site [active] 405534008776 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534008777 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405534008778 active site 405534008779 metal binding site [ion binding]; metal-binding site 405534008780 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 405534008781 putative monooxygenase; Provisional; Region: PRK11118 405534008782 DoxX-like family; Region: DoxX_2; pfam13564 405534008783 Transcriptional regulators [Transcription]; Region: MarR; COG1846 405534008784 MarR family; Region: MarR_2; pfam12802 405534008785 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 405534008786 Cytochrome P450; Region: p450; pfam00067 405534008787 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 405534008788 Flavodoxin; Region: Flavodoxin_1; pfam00258 405534008789 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 405534008790 FAD binding pocket [chemical binding]; other site 405534008791 FAD binding motif [chemical binding]; other site 405534008792 catalytic residues [active] 405534008793 NAD binding pocket [chemical binding]; other site 405534008794 phosphate binding motif [ion binding]; other site 405534008795 beta-alpha-beta structure motif; other site 405534008796 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 405534008797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534008798 putative substrate translocation pore; other site 405534008799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534008800 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 405534008801 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 405534008802 ATP-grasp domain; Region: ATP-grasp_4; cl17255 405534008803 H+ Antiporter protein; Region: 2A0121; TIGR00900 405534008804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534008805 putative substrate translocation pore; other site 405534008806 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 405534008807 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405534008808 D-cysteine desulfhydrase; Validated; Region: PRK03910 405534008809 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 405534008810 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405534008811 catalytic residue [active] 405534008812 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 405534008813 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405534008814 active site 405534008815 metal binding site [ion binding]; metal-binding site 405534008816 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 405534008817 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 405534008818 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 405534008819 CAAX protease self-immunity; Region: Abi; pfam02517 405534008820 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 405534008821 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405534008822 DNA binding residues [nucleotide binding] 405534008823 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 405534008824 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 405534008825 hypothetical protein; Provisional; Region: PRK06762 405534008826 AAA domain; Region: AAA_33; pfam13671 405534008827 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 405534008828 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405534008829 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405534008830 Walker A/P-loop; other site 405534008831 ATP binding site [chemical binding]; other site 405534008832 Q-loop/lid; other site 405534008833 ABC transporter signature motif; other site 405534008834 Walker B; other site 405534008835 D-loop; other site 405534008836 H-loop/switch region; other site 405534008837 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 405534008838 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405534008839 FtsX-like permease family; Region: FtsX; pfam02687 405534008840 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534008841 dimerization interface [polypeptide binding]; other site 405534008842 putative Zn2+ binding site [ion binding]; other site 405534008843 putative DNA binding site [nucleotide binding]; other site 405534008844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534008845 H+ Antiporter protein; Region: 2A0121; TIGR00900 405534008846 putative substrate translocation pore; other site 405534008847 DinB superfamily; Region: DinB_2; pfam12867 405534008848 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534008849 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534008850 dimerization interface [polypeptide binding]; other site 405534008851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534008852 dimer interface [polypeptide binding]; other site 405534008853 phosphorylation site [posttranslational modification] 405534008854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534008855 ATP binding site [chemical binding]; other site 405534008856 Mg2+ binding site [ion binding]; other site 405534008857 G-X-G motif; other site 405534008858 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534008859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534008860 active site 405534008861 phosphorylation site [posttranslational modification] 405534008862 intermolecular recognition site; other site 405534008863 dimerization interface [polypeptide binding]; other site 405534008864 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534008865 DNA binding site [nucleotide binding] 405534008866 Predicted membrane protein [Function unknown]; Region: COG2364 405534008867 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405534008868 Transcriptional regulators [Transcription]; Region: MarR; COG1846 405534008869 MarR family; Region: MarR; pfam01047 405534008870 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 405534008871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534008872 Coenzyme A binding pocket [chemical binding]; other site 405534008873 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 405534008874 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405534008875 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405534008876 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405534008877 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 405534008878 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405534008879 binding surface 405534008880 TPR motif; other site 405534008881 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405534008882 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405534008883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405534008884 TPR motif; other site 405534008885 binding surface 405534008886 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 405534008887 putative dimer interface [polypeptide binding]; other site 405534008888 catalytic triad [active] 405534008889 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 405534008890 Uncharacterized conserved protein [Function unknown]; Region: COG4198 405534008891 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 405534008892 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 405534008893 glyoxylate reductase; Reviewed; Region: PRK13243 405534008894 putative ligand binding site [chemical binding]; other site 405534008895 putative NAD binding site [chemical binding]; other site 405534008896 putative catalytic site [active] 405534008897 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 405534008898 L-serine binding site [chemical binding]; other site 405534008899 ACT domain interface; other site 405534008900 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 405534008901 homodimer interface [polypeptide binding]; other site 405534008902 substrate-cofactor binding pocket; other site 405534008903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534008904 catalytic residue [active] 405534008905 Uncharacterized conserved protein [Function unknown]; Region: COG2155 405534008906 Cupin domain; Region: Cupin_2; cl17218 405534008907 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 405534008908 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405534008909 Penicillin amidase; Region: Penicil_amidase; pfam01804 405534008910 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 405534008911 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 405534008912 active site 405534008913 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 405534008914 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 405534008915 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 405534008916 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405534008917 amidase catalytic site [active] 405534008918 Zn binding residues [ion binding]; other site 405534008919 substrate binding site [chemical binding]; other site 405534008920 Bacterial SH3 domain; Region: SH3_3; pfam08239 405534008921 S-layer homology domain; Region: SLH; pfam00395 405534008922 S-layer homology domain; Region: SLH; pfam00395 405534008923 S-layer homology domain; Region: SLH; pfam00395 405534008924 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 405534008925 A new structural DNA glycosylase; Region: AlkD_like; cd06561 405534008926 active site 405534008927 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 405534008928 S-layer homology domain; Region: SLH; pfam00395 405534008929 S-layer homology domain; Region: SLH; pfam00395 405534008930 S-layer homology domain; Region: SLH; pfam00395 405534008931 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 405534008932 putative metal binding site [ion binding]; other site 405534008933 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534008934 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 405534008935 NETI protein; Region: NETI; pfam14044 405534008936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534008937 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534008938 putative substrate translocation pore; other site 405534008939 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405534008940 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405534008941 TAP-like protein; Region: Abhydrolase_4; pfam08386 405534008942 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405534008943 MarR family; Region: MarR_2; pfam12802 405534008944 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534008945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534008946 putative substrate translocation pore; other site 405534008947 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405534008948 Beta-lactamase; Region: Beta-lactamase; pfam00144 405534008949 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 405534008950 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 405534008951 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405534008952 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534008953 Walker A/P-loop; other site 405534008954 ATP binding site [chemical binding]; other site 405534008955 Q-loop/lid; other site 405534008956 ABC transporter signature motif; other site 405534008957 Walker B; other site 405534008958 D-loop; other site 405534008959 H-loop/switch region; other site 405534008960 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 405534008961 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534008962 putative DNA binding site [nucleotide binding]; other site 405534008963 putative Zn2+ binding site [ion binding]; other site 405534008964 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405534008965 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534008966 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534008967 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 405534008968 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 405534008969 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 405534008970 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405534008971 SWIM zinc finger; Region: SWIM; pfam04434 405534008972 YwiC-like protein; Region: YwiC; pfam14256 405534008973 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 405534008974 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405534008975 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405534008976 Walker A/P-loop; other site 405534008977 ATP binding site [chemical binding]; other site 405534008978 Q-loop/lid; other site 405534008979 ABC transporter signature motif; other site 405534008980 Walker B; other site 405534008981 D-loop; other site 405534008982 H-loop/switch region; other site 405534008983 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405534008984 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 405534008985 Walker A/P-loop; other site 405534008986 ATP binding site [chemical binding]; other site 405534008987 Q-loop/lid; other site 405534008988 ABC transporter signature motif; other site 405534008989 Walker B; other site 405534008990 D-loop; other site 405534008991 H-loop/switch region; other site 405534008992 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 405534008993 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 405534008994 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 405534008995 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 405534008996 Predicted membrane protein [Function unknown]; Region: COG1288 405534008997 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 405534008998 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 405534008999 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 405534009000 DNA binding residues [nucleotide binding] 405534009001 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405534009002 dimer interface [polypeptide binding]; other site 405534009003 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 405534009004 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405534009005 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 405534009006 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405534009007 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534009008 non-specific DNA binding site [nucleotide binding]; other site 405534009009 salt bridge; other site 405534009010 sequence-specific DNA binding site [nucleotide binding]; other site 405534009011 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 405534009012 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 405534009013 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 405534009014 putative active site [active] 405534009015 putative NTP binding site [chemical binding]; other site 405534009016 putative nucleic acid binding site [nucleotide binding]; other site 405534009017 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 405534009018 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 405534009019 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 405534009020 putative deacylase active site [active] 405534009021 histidyl-tRNA synthetase; Provisional; Region: PRK12420 405534009022 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 405534009023 dimer interface [polypeptide binding]; other site 405534009024 motif 1; other site 405534009025 active site 405534009026 motif 2; other site 405534009027 motif 3; other site 405534009028 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 405534009029 anticodon binding site; other site 405534009030 Predicted transcriptional regulators [Transcription]; Region: COG1733 405534009031 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 405534009032 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 405534009033 dimer interface [polypeptide binding]; other site 405534009034 FMN binding site [chemical binding]; other site 405534009035 pyruvate kinase; Validated; Region: PRK06739 405534009036 active site 405534009037 domain interfaces; other site 405534009038 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 405534009039 classical (c) SDRs; Region: SDR_c; cd05233 405534009040 NAD(P) binding site [chemical binding]; other site 405534009041 active site 405534009042 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 405534009043 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405534009044 Walker A/P-loop; other site 405534009045 ATP binding site [chemical binding]; other site 405534009046 Q-loop/lid; other site 405534009047 ABC transporter signature motif; other site 405534009048 Walker B; other site 405534009049 D-loop; other site 405534009050 H-loop/switch region; other site 405534009051 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 405534009052 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534009053 non-specific DNA binding site [nucleotide binding]; other site 405534009054 salt bridge; other site 405534009055 sequence-specific DNA binding site [nucleotide binding]; other site 405534009056 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 405534009057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534009058 motif II; other site 405534009059 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 405534009060 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 405534009061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405534009062 Coenzyme A binding pocket [chemical binding]; other site 405534009063 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 405534009064 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 405534009065 nudix motif; other site 405534009066 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 405534009067 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534009068 putative metal binding site [ion binding]; other site 405534009069 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 405534009070 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 405534009071 maltose O-acetyltransferase; Provisional; Region: PRK10092 405534009072 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 405534009073 active site 405534009074 substrate binding site [chemical binding]; other site 405534009075 trimer interface [polypeptide binding]; other site 405534009076 CoA binding site [chemical binding]; other site 405534009077 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 405534009078 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 405534009079 active site 405534009080 HIGH motif; other site 405534009081 dimer interface [polypeptide binding]; other site 405534009082 KMSKS motif; other site 405534009083 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 405534009084 Domain of unknown function DUF20; Region: UPF0118; pfam01594 405534009085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534009086 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405534009087 Coenzyme A binding pocket [chemical binding]; other site 405534009088 ydaO/yuaA leader 405534009089 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 405534009090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534009091 S-adenosylmethionine binding site [chemical binding]; other site 405534009092 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 405534009093 CGNR zinc finger; Region: zf-CGNR; pfam11706 405534009094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534009095 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534009096 putative substrate translocation pore; other site 405534009097 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 405534009098 hypothetical protein; Provisional; Region: PRK04164 405534009099 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405534009100 ATP synthase I chain; Region: ATP_synt_I; cl09170 405534009101 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 405534009102 Domain of unknown function DUF21; Region: DUF21; pfam01595 405534009103 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 405534009104 Transporter associated domain; Region: CorC_HlyC; smart01091 405534009105 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 405534009106 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405534009107 DNA binding residues [nucleotide binding] 405534009108 putative dimer interface [polypeptide binding]; other site 405534009109 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 405534009110 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 405534009111 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 405534009112 substrate binding site; other site 405534009113 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 405534009114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405534009115 NAD(P) binding site [chemical binding]; other site 405534009116 active site 405534009117 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 405534009118 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405534009119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534009120 S-adenosylmethionine binding site [chemical binding]; other site 405534009121 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 405534009122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405534009123 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 405534009124 NAD(P) binding site [chemical binding]; other site 405534009125 active site 405534009126 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 405534009127 Variant SH3 domain; Region: SH3_2; pfam07653 405534009128 peptide ligand binding site [polypeptide binding]; other site 405534009129 Src Homology 3 domain superfamily; Region: SH3; cl17036 405534009130 EamA-like transporter family; Region: EamA; pfam00892 405534009131 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405534009132 EamA-like transporter family; Region: EamA; pfam00892 405534009133 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 405534009134 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 405534009135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 405534009136 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 405534009137 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 405534009138 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 405534009139 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 405534009140 N- and C-terminal domain interface [polypeptide binding]; other site 405534009141 active site 405534009142 catalytic site [active] 405534009143 metal binding site [ion binding]; metal-binding site 405534009144 carbohydrate binding site [chemical binding]; other site 405534009145 ATP binding site [chemical binding]; other site 405534009146 GntP family permease; Region: GntP_permease; pfam02447 405534009147 fructuronate transporter; Provisional; Region: PRK10034; cl15264 405534009148 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 405534009149 active site 405534009150 intersubunit interactions; other site 405534009151 catalytic residue [active] 405534009152 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 405534009153 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405534009154 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 405534009155 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 405534009156 TPP-binding site [chemical binding]; other site 405534009157 dimer interface [polypeptide binding]; other site 405534009158 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 405534009159 PYR/PP interface [polypeptide binding]; other site 405534009160 dimer interface [polypeptide binding]; other site 405534009161 TPP binding site [chemical binding]; other site 405534009162 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405534009163 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 405534009164 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 405534009165 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 405534009166 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 405534009167 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405534009168 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 405534009169 putative NAD(P) binding site [chemical binding]; other site 405534009170 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 405534009171 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 405534009172 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 405534009173 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405534009174 putative NAD(P) binding site [chemical binding]; other site 405534009175 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 405534009176 classical (c) SDRs; Region: SDR_c; cd05233 405534009177 NAD(P) binding site [chemical binding]; other site 405534009178 active site 405534009179 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 405534009180 dimer interface [polypeptide binding]; other site 405534009181 FMN binding site [chemical binding]; other site 405534009182 BNR repeat-like domain; Region: BNR_2; pfam13088 405534009183 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405534009184 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405534009185 active site 405534009186 catalytic tetrad [active] 405534009187 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 405534009188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534009189 putative substrate translocation pore; other site 405534009190 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 405534009191 active site 1 [active] 405534009192 dimer interface [polypeptide binding]; other site 405534009193 hexamer interface [polypeptide binding]; other site 405534009194 active site 2 [active] 405534009195 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 405534009196 hexamer interface [polypeptide binding]; other site 405534009197 active site 2 [active] 405534009198 hypothetical protein; Provisional; Region: PRK02487 405534009199 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 405534009200 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 405534009201 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 405534009202 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 405534009203 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 405534009204 putative active site [active] 405534009205 putative NTP binding site [chemical binding]; other site 405534009206 putative nucleic acid binding site [nucleotide binding]; other site 405534009207 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 405534009208 IDEAL domain; Region: IDEAL; pfam08858 405534009209 Transcriptional regulator; Region: Rrf2; pfam02082 405534009210 Rrf2 family protein; Region: rrf2_super; TIGR00738 405534009211 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 405534009212 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 405534009213 ArsC family; Region: ArsC; pfam03960 405534009214 putative catalytic residues [active] 405534009215 thiol/disulfide switch; other site 405534009216 Predicted transcriptional regulators [Transcription]; Region: COG1733 405534009217 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534009218 dimerization interface [polypeptide binding]; other site 405534009219 putative DNA binding site [nucleotide binding]; other site 405534009220 putative Zn2+ binding site [ion binding]; other site 405534009221 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 405534009222 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405534009223 DNA-binding site [nucleotide binding]; DNA binding site 405534009224 UTRA domain; Region: UTRA; pfam07702 405534009225 putative oxidoreductase; Provisional; Region: PRK10206 405534009226 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405534009227 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 405534009228 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 405534009229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 405534009230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534009231 S-adenosylmethionine binding site [chemical binding]; other site 405534009232 Predicted transcriptional regulators [Transcription]; Region: COG1733 405534009233 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 405534009234 Predicted transcriptional regulators [Transcription]; Region: COG1733 405534009235 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534009236 dimerization interface [polypeptide binding]; other site 405534009237 putative DNA binding site [nucleotide binding]; other site 405534009238 putative Zn2+ binding site [ion binding]; other site 405534009239 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405534009240 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405534009241 active site 405534009242 catalytic tetrad [active] 405534009243 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 405534009244 putative hydrophobic ligand binding site [chemical binding]; other site 405534009245 protein interface [polypeptide binding]; other site 405534009246 gate; other site 405534009247 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 405534009248 catalytic triad [active] 405534009249 oxyanion hole [active] 405534009250 active site 405534009251 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405534009252 Phosphotransferase enzyme family; Region: APH; pfam01636 405534009253 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 405534009254 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 405534009255 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 405534009256 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 405534009257 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534009258 Coenzyme A binding pocket [chemical binding]; other site 405534009259 C factor cell-cell signaling protein; Provisional; Region: PRK09009 405534009260 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405534009261 NAD(P) binding site [chemical binding]; other site 405534009262 active site 405534009263 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405534009264 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405534009265 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405534009266 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 405534009267 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405534009268 acyl-activating enzyme (AAE) consensus motif; other site 405534009269 AMP binding site [chemical binding]; other site 405534009270 active site 405534009271 CoA binding site [chemical binding]; other site 405534009272 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 405534009273 Predicted transcriptional regulators [Transcription]; Region: COG1733 405534009274 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534009275 dimerization interface [polypeptide binding]; other site 405534009276 putative DNA binding site [nucleotide binding]; other site 405534009277 putative Zn2+ binding site [ion binding]; other site 405534009278 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534009279 dimerization interface [polypeptide binding]; other site 405534009280 putative DNA binding site [nucleotide binding]; other site 405534009281 putative Zn2+ binding site [ion binding]; other site 405534009282 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 405534009283 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 405534009284 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 405534009285 NodB motif; other site 405534009286 putative active site [active] 405534009287 putative catalytic site [active] 405534009288 putative Zn binding site [ion binding]; other site 405534009289 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 405534009290 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 405534009291 DXD motif; other site 405534009292 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405534009293 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 405534009294 active site 405534009295 hypothetical protein; Provisional; Region: PRK12856 405534009296 CAAX protease self-immunity; Region: Abi; pfam02517 405534009297 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534009298 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534009299 Protein of unknown function (DUF3963); Region: DUF3963; pfam13124 405534009300 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 405534009301 Predicted transcriptional regulator [Transcription]; Region: COG2378 405534009302 HTH domain; Region: HTH_11; pfam08279 405534009303 WYL domain; Region: WYL; pfam13280 405534009304 ABC-2 type transporter; Region: ABC2_membrane; cl17235 405534009305 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 405534009306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534009307 Walker A/P-loop; other site 405534009308 ATP binding site [chemical binding]; other site 405534009309 Q-loop/lid; other site 405534009310 ABC transporter signature motif; other site 405534009311 Walker B; other site 405534009312 D-loop; other site 405534009313 H-loop/switch region; other site 405534009314 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 405534009315 Predicted transcriptional regulators [Transcription]; Region: COG1695 405534009316 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405534009317 hydroxylamine reductase; Provisional; Region: PRK12310 405534009318 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 405534009319 ACS interaction site; other site 405534009320 CODH interaction site; other site 405534009321 metal cluster binding site [ion binding]; other site 405534009322 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 405534009323 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405534009324 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 405534009325 metal binding site [ion binding]; metal-binding site 405534009326 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 405534009327 hypothetical protein; Provisional; Region: PRK06771 405534009328 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 405534009329 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 405534009330 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 405534009331 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405534009332 active site 405534009333 metal binding site [ion binding]; metal-binding site 405534009334 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 405534009335 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405534009336 ligand binding site [chemical binding]; other site 405534009337 flexible hinge region; other site 405534009338 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 405534009339 Protein of unknown function, DUF606; Region: DUF606; pfam04657 405534009340 Protein of unknown function, DUF606; Region: DUF606; pfam04657 405534009341 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405534009342 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 405534009343 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 405534009344 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 405534009345 Predicted transcriptional regulators [Transcription]; Region: COG1695 405534009346 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405534009347 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 405534009348 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 405534009349 putative NAD(P) binding site [chemical binding]; other site 405534009350 dimer interface [polypeptide binding]; other site 405534009351 putative transport protein YifK; Provisional; Region: PRK10746 405534009352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534009353 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 405534009354 putative substrate translocation pore; other site 405534009355 Haemolysin XhlA; Region: XhlA; pfam10779 405534009356 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 405534009357 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 405534009358 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 405534009359 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 405534009360 transmembrane helices; other site 405534009361 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405534009362 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 405534009363 putative ligand binding residues [chemical binding]; other site 405534009364 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405534009365 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405534009366 ABC-ATPase subunit interface; other site 405534009367 dimer interface [polypeptide binding]; other site 405534009368 putative PBP binding regions; other site 405534009369 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405534009370 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405534009371 ABC-ATPase subunit interface; other site 405534009372 dimer interface [polypeptide binding]; other site 405534009373 putative PBP binding regions; other site 405534009374 Protein of unknown function (DUF817); Region: DUF817; pfam05675 405534009375 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 405534009376 DinB superfamily; Region: DinB_2; pfam12867 405534009377 DinB family; Region: DinB; cl17821 405534009378 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 405534009379 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 405534009380 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405534009381 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405534009382 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405534009383 dimerization interface [polypeptide binding]; other site 405534009384 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405534009385 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 405534009386 NADP binding site [chemical binding]; other site 405534009387 dimer interface [polypeptide binding]; other site 405534009388 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405534009389 catalytic core [active] 405534009390 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405534009391 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534009392 Coenzyme A binding pocket [chemical binding]; other site 405534009393 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 405534009394 MutS domain III; Region: MutS_III; pfam05192 405534009395 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534009396 Walker A/P-loop; other site 405534009397 ATP binding site [chemical binding]; other site 405534009398 Q-loop/lid; other site 405534009399 ABC transporter signature motif; other site 405534009400 Walker B; other site 405534009401 D-loop; other site 405534009402 H-loop/switch region; other site 405534009403 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 405534009404 oligoendopeptidase F; Region: pepF; TIGR00181 405534009405 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 405534009406 active site 405534009407 Zn binding site [ion binding]; other site 405534009408 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405534009409 Beta-lactamase; Region: Beta-lactamase; pfam00144 405534009410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534009411 putative substrate translocation pore; other site 405534009412 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534009413 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405534009414 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405534009415 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 405534009416 putative dimerization interface [polypeptide binding]; other site 405534009417 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 405534009418 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 405534009419 putative active site [active] 405534009420 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 405534009421 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 405534009422 active site 405534009423 catalytic site [active] 405534009424 metal binding site [ion binding]; metal-binding site 405534009425 FAD binding domain; Region: FAD_binding_3; pfam01494 405534009426 hypothetical protein; Provisional; Region: PRK07236 405534009427 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 405534009428 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534009429 dimerization interface [polypeptide binding]; other site 405534009430 putative DNA binding site [nucleotide binding]; other site 405534009431 putative Zn2+ binding site [ion binding]; other site 405534009432 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405534009433 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 405534009434 putative NAD(P) binding site [chemical binding]; other site 405534009435 Uncharacterized conserved protein [Function unknown]; Region: COG0397 405534009436 hypothetical protein; Validated; Region: PRK00029 405534009437 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405534009438 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405534009439 TPR motif; other site 405534009440 binding surface 405534009441 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 405534009442 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 405534009443 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 405534009444 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 405534009445 Sodium Bile acid symporter family; Region: SBF; cl17470 405534009446 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 405534009447 FAD binding domain; Region: FAD_binding_4; pfam01565 405534009448 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 405534009449 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405534009450 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 405534009451 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 405534009452 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 405534009453 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 405534009454 FOG: PKD repeat [General function prediction only]; Region: COG3291 405534009455 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 405534009456 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 405534009457 MgtC family; Region: MgtC; pfam02308 405534009458 Predicted acetyltransferase [General function prediction only]; Region: COG3981 405534009459 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405534009460 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 405534009461 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 405534009462 putative metal binding site [ion binding]; other site 405534009463 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405534009464 active site 405534009465 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405534009466 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 405534009467 substrate binding pocket [chemical binding]; other site 405534009468 membrane-bound complex binding site; other site 405534009469 hinge residues; other site 405534009470 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405534009471 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405534009472 Walker A/P-loop; other site 405534009473 ATP binding site [chemical binding]; other site 405534009474 Q-loop/lid; other site 405534009475 ABC transporter signature motif; other site 405534009476 Walker B; other site 405534009477 D-loop; other site 405534009478 H-loop/switch region; other site 405534009479 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 405534009480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534009481 dimer interface [polypeptide binding]; other site 405534009482 conserved gate region; other site 405534009483 putative PBP binding loops; other site 405534009484 ABC-ATPase subunit interface; other site 405534009485 VanW like protein; Region: VanW; pfam04294 405534009486 Sensor protein DegS; Region: DegS; pfam05384 405534009487 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 405534009488 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 405534009489 exonuclease; Provisional; Region: PRK06722 405534009490 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 405534009491 active site 405534009492 catalytic site [active] 405534009493 substrate binding site [chemical binding]; other site 405534009494 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405534009495 DNA-binding site [nucleotide binding]; DNA binding site 405534009496 RNA-binding motif; other site 405534009497 flavodoxin; Provisional; Region: PRK06703 405534009498 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 405534009499 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 405534009500 nudix motif; other site 405534009501 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 405534009502 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 405534009503 trimer interface [polypeptide binding]; other site 405534009504 active site 405534009505 substrate binding site [chemical binding]; other site 405534009506 CoA binding site [chemical binding]; other site 405534009507 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009508 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009509 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009510 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009511 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009512 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009513 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009514 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009515 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009516 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009517 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009518 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009519 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009520 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009521 short chain dehydrogenase; Provisional; Region: PRK06924 405534009522 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 405534009523 NADP binding site [chemical binding]; other site 405534009524 homodimer interface [polypeptide binding]; other site 405534009525 active site 405534009526 Predicted acetyltransferase [General function prediction only]; Region: COG3393 405534009527 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405534009528 argininosuccinate lyase; Provisional; Region: PRK06705 405534009529 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 405534009530 active sites [active] 405534009531 tetramer interface [polypeptide binding]; other site 405534009532 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405534009533 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405534009534 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 405534009535 active site 405534009536 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 405534009537 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 405534009538 Na binding site [ion binding]; other site 405534009539 Protein of unknown function (DUF997); Region: DUF997; pfam06196 405534009540 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 405534009541 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 405534009542 NAD(P) binding site [chemical binding]; other site 405534009543 DinB family; Region: DinB; cl17821 405534009544 DinB superfamily; Region: DinB_2; pfam12867 405534009545 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 405534009546 active site 405534009547 catalytic residues [active] 405534009548 DNA binding site [nucleotide binding] 405534009549 Int/Topo IB signature motif; other site 405534009550 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405534009551 active site 405534009552 DNA binding site [nucleotide binding] 405534009553 Int/Topo IB signature motif; other site 405534009554 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 405534009555 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 405534009556 catalytic residues [active] 405534009557 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 405534009558 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 405534009559 NAD(P) binding site [chemical binding]; other site 405534009560 homotetramer interface [polypeptide binding]; other site 405534009561 homodimer interface [polypeptide binding]; other site 405534009562 active site 405534009563 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 405534009564 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 405534009565 Divergent PAP2 family; Region: DUF212; pfam02681 405534009566 Predicted permeases [General function prediction only]; Region: RarD; COG2962 405534009567 EamA-like transporter family; Region: EamA; pfam00892 405534009568 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 405534009569 Domain of unknown function DUF59; Region: DUF59; pfam01883 405534009570 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 405534009571 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 405534009572 Walker A motif; other site 405534009573 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 405534009574 MoaE interaction surface [polypeptide binding]; other site 405534009575 MoeB interaction surface [polypeptide binding]; other site 405534009576 thiocarboxylated glycine; other site 405534009577 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 405534009578 MoaE homodimer interface [polypeptide binding]; other site 405534009579 MoaD interaction [polypeptide binding]; other site 405534009580 active site residues [active] 405534009581 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 405534009582 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 405534009583 dimer interface [polypeptide binding]; other site 405534009584 putative functional site; other site 405534009585 putative MPT binding site; other site 405534009586 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 405534009587 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 405534009588 ATP binding site [chemical binding]; other site 405534009589 substrate interface [chemical binding]; other site 405534009590 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 405534009591 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 405534009592 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405534009593 FeS/SAM binding site; other site 405534009594 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 405534009595 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 405534009596 Uncharacterized conserved protein [Function unknown]; Region: COG5609 405534009597 Uncharacterized conserved protein [Function unknown]; Region: COG2427 405534009598 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 405534009599 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 405534009600 catalytic loop [active] 405534009601 iron binding site [ion binding]; other site 405534009602 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 405534009603 4Fe-4S binding domain; Region: Fer4; pfam00037 405534009604 4Fe-4S binding domain; Region: Fer4; pfam00037 405534009605 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 405534009606 [4Fe-4S] binding site [ion binding]; other site 405534009607 molybdopterin cofactor binding site; other site 405534009608 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 405534009609 molybdopterin cofactor binding site; other site 405534009610 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405534009611 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 405534009612 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405534009613 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405534009614 Tubulin like; Region: Tubulin_2; pfam13809 405534009615 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 405534009616 metal ion-dependent adhesion site (MIDAS); other site 405534009617 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405534009618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534009619 S-adenosylmethionine binding site [chemical binding]; other site 405534009620 O-methyltransferase; Region: Methyltransf_2; pfam00891 405534009621 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405534009622 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405534009623 peptide binding site [polypeptide binding]; other site 405534009624 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405534009625 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405534009626 peptide binding site [polypeptide binding]; other site 405534009627 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405534009628 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405534009629 peptide binding site [polypeptide binding]; other site 405534009630 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 405534009631 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405534009632 Transcriptional regulator [Transcription]; Region: LytR; COG1316 405534009633 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 405534009634 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405534009635 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405534009636 DNA binding residues [nucleotide binding] 405534009637 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405534009638 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534009639 active site 405534009640 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 405534009641 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405534009642 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405534009643 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405534009644 Walker A/P-loop; other site 405534009645 ATP binding site [chemical binding]; other site 405534009646 Q-loop/lid; other site 405534009647 ABC transporter signature motif; other site 405534009648 Walker B; other site 405534009649 D-loop; other site 405534009650 H-loop/switch region; other site 405534009651 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534009652 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534009653 putative oxidoreductase; Provisional; Region: PRK11579 405534009654 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405534009655 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 405534009656 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 405534009657 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 405534009658 CAP-like domain; other site 405534009659 active site 405534009660 primary dimer interface [polypeptide binding]; other site 405534009661 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405534009662 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405534009663 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405534009664 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405534009665 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 405534009666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534009667 ATP binding site [chemical binding]; other site 405534009668 Mg2+ binding site [ion binding]; other site 405534009669 G-X-G motif; other site 405534009670 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 405534009671 anchoring element; other site 405534009672 dimer interface [polypeptide binding]; other site 405534009673 ATP binding site [chemical binding]; other site 405534009674 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 405534009675 active site 405534009676 putative metal-binding site [ion binding]; other site 405534009677 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 405534009678 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 405534009679 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 405534009680 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 405534009681 protein binding site [polypeptide binding]; other site 405534009682 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534009683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534009684 active site 405534009685 phosphorylation site [posttranslational modification] 405534009686 intermolecular recognition site; other site 405534009687 dimerization interface [polypeptide binding]; other site 405534009688 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534009689 DNA binding site [nucleotide binding] 405534009690 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 405534009691 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405534009692 FeS/SAM binding site; other site 405534009693 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 405534009694 Class III ribonucleotide reductase; Region: RNR_III; cd01675 405534009695 effector binding site; other site 405534009696 active site 405534009697 Zn binding site [ion binding]; other site 405534009698 glycine loop; other site 405534009699 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 405534009700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 405534009701 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 405534009702 active site 405534009703 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 405534009704 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405534009705 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405534009706 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 405534009707 active site 405534009708 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 405534009709 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 405534009710 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 405534009711 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 405534009712 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 405534009713 active site 405534009714 catalytic site [active] 405534009715 substrate binding site [chemical binding]; other site 405534009716 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 405534009717 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 405534009718 catalytic residues [active] 405534009719 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405534009720 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405534009721 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405534009722 Walker A/P-loop; other site 405534009723 ATP binding site [chemical binding]; other site 405534009724 ABC transporter signature motif; other site 405534009725 Walker B; other site 405534009726 D-loop; other site 405534009727 H-loop/switch region; other site 405534009728 aconitate hydratase; Validated; Region: PRK09277 405534009729 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 405534009730 substrate binding site [chemical binding]; other site 405534009731 ligand binding site [chemical binding]; other site 405534009732 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 405534009733 substrate binding site [chemical binding]; other site 405534009734 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 405534009735 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405534009736 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 405534009737 NodB motif; other site 405534009738 active site 405534009739 catalytic site [active] 405534009740 metal binding site [ion binding]; metal-binding site 405534009741 Small acid-soluble spore protein P family; Region: SspP; cl12105 405534009742 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 405534009743 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 405534009744 putative dimer interface [polypeptide binding]; other site 405534009745 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534009746 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 405534009747 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 405534009748 active site 405534009749 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 405534009750 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 405534009751 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405534009752 nudix motif; other site 405534009753 SAP domain; Region: SAP; pfam02037 405534009754 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405534009755 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534009756 non-specific DNA binding site [nucleotide binding]; other site 405534009757 salt bridge; other site 405534009758 sequence-specific DNA binding site [nucleotide binding]; other site 405534009759 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405534009760 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 405534009761 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 405534009762 dimer interface [polypeptide binding]; other site 405534009763 active site 405534009764 acyl-CoA synthetase; Validated; Region: PRK07638 405534009765 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405534009766 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405534009767 acyl-activating enzyme (AAE) consensus motif; other site 405534009768 acyl-activating enzyme (AAE) consensus motif; other site 405534009769 AMP binding site [chemical binding]; other site 405534009770 active site 405534009771 CoA binding site [chemical binding]; other site 405534009772 BioY family; Region: BioY; pfam02632 405534009773 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 405534009774 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 405534009775 dimer interface [polypeptide binding]; other site 405534009776 acyl-activating enzyme (AAE) consensus motif; other site 405534009777 putative active site [active] 405534009778 AMP binding site [chemical binding]; other site 405534009779 putative CoA binding site [chemical binding]; other site 405534009780 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 405534009781 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405534009782 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405534009783 Walker A/P-loop; other site 405534009784 ATP binding site [chemical binding]; other site 405534009785 Q-loop/lid; other site 405534009786 ABC transporter signature motif; other site 405534009787 Walker B; other site 405534009788 D-loop; other site 405534009789 H-loop/switch region; other site 405534009790 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405534009791 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534009792 non-specific DNA binding site [nucleotide binding]; other site 405534009793 salt bridge; other site 405534009794 sequence-specific DNA binding site [nucleotide binding]; other site 405534009795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534009796 Coenzyme A binding pocket [chemical binding]; other site 405534009797 S-layer homology domain; Region: SLH; pfam00395 405534009798 S-layer homology domain; Region: SLH; pfam00395 405534009799 S-layer homology domain; Region: SLH; pfam00395 405534009800 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 405534009801 active site 405534009802 catalytic motif [active] 405534009803 Zn binding site [ion binding]; other site 405534009804 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 405534009805 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405534009806 amidase catalytic site [active] 405534009807 Zn binding residues [ion binding]; other site 405534009808 substrate binding site [chemical binding]; other site 405534009809 active site 405534009810 Protein phosphatase 2C; Region: PP2C_2; pfam13672 405534009811 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405534009812 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405534009813 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534009814 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 405534009815 dimer interface [polypeptide binding]; other site 405534009816 putative metal binding site [ion binding]; other site 405534009817 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405534009818 PAS domain; Region: PAS_9; pfam13426 405534009819 putative active site [active] 405534009820 heme pocket [chemical binding]; other site 405534009821 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 405534009822 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405534009823 putative active site [active] 405534009824 heme pocket [chemical binding]; other site 405534009825 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534009826 dimer interface [polypeptide binding]; other site 405534009827 phosphorylation site [posttranslational modification] 405534009828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534009829 ATP binding site [chemical binding]; other site 405534009830 Mg2+ binding site [ion binding]; other site 405534009831 G-X-G motif; other site 405534009832 Predicted esterase [General function prediction only]; Region: COG0400 405534009833 putative hydrolase; Provisional; Region: PRK11460 405534009834 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 405534009835 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534009836 Zn binding site [ion binding]; other site 405534009837 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 405534009838 Zn binding site [ion binding]; other site 405534009839 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 405534009840 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 405534009841 Na binding site [ion binding]; other site 405534009842 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 405534009843 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 405534009844 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 405534009845 active site 405534009846 FMN binding site [chemical binding]; other site 405534009847 substrate binding site [chemical binding]; other site 405534009848 3Fe-4S cluster binding site [ion binding]; other site 405534009849 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 405534009850 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 405534009851 FMN binding site [chemical binding]; other site 405534009852 active site 405534009853 substrate binding site [chemical binding]; other site 405534009854 catalytic residue [active] 405534009855 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 405534009856 agmatinase; Region: agmatinase; TIGR01230 405534009857 Agmatinase-like family; Region: Agmatinase-like; cd09990 405534009858 active site 405534009859 oligomer interface [polypeptide binding]; other site 405534009860 Mn binding site [ion binding]; other site 405534009861 imidazolonepropionase; Validated; Region: PRK09356 405534009862 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 405534009863 active site 405534009864 urocanate hydratase; Provisional; Region: PRK05414 405534009865 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 405534009866 active sites [active] 405534009867 tetramer interface [polypeptide binding]; other site 405534009868 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 405534009869 hexamer interface [polypeptide binding]; other site 405534009870 RNA binding site [nucleotide binding]; other site 405534009871 Histidine-zinc binding site [chemical binding]; other site 405534009872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534009873 S-adenosylmethionine binding site [chemical binding]; other site 405534009874 DJ-1 family protein; Region: not_thiJ; TIGR01383 405534009875 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 405534009876 conserved cys residue [active] 405534009877 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 405534009878 AAA domain; Region: AAA_28; pfam13521 405534009879 active site 405534009880 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 405534009881 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009882 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009883 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009884 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009885 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009886 Domain of unknown function DUF11; Region: DUF11; cl17728 405534009887 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009888 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009889 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009890 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009891 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009892 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009893 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009894 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009895 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 405534009896 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 405534009897 putative active site [active] 405534009898 putative NTP binding site [chemical binding]; other site 405534009899 putative nucleic acid binding site [nucleotide binding]; other site 405534009900 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 405534009901 active site 405534009902 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534009903 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 405534009904 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 405534009905 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 405534009906 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405534009907 EamA-like transporter family; Region: EamA; pfam00892 405534009908 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 405534009909 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405534009910 metal binding site [ion binding]; metal-binding site 405534009911 dimer interface [polypeptide binding]; other site 405534009912 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 405534009913 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405534009914 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405534009915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534009916 Walker A/P-loop; other site 405534009917 ATP binding site [chemical binding]; other site 405534009918 Q-loop/lid; other site 405534009919 ABC transporter signature motif; other site 405534009920 Walker B; other site 405534009921 D-loop; other site 405534009922 H-loop/switch region; other site 405534009923 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 405534009924 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405534009925 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 405534009926 putative dimerization interface [polypeptide binding]; other site 405534009927 putative substrate binding pocket [chemical binding]; other site 405534009928 holin-like protein; Validated; Region: PRK01658 405534009929 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 405534009930 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405534009931 nudix motif; other site 405534009932 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 405534009933 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405534009934 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405534009935 amidase catalytic site [active] 405534009936 Zn binding residues [ion binding]; other site 405534009937 substrate binding site [chemical binding]; other site 405534009938 S-layer homology domain; Region: SLH; pfam00395 405534009939 S-layer homology domain; Region: SLH; pfam00395 405534009940 S-layer homology domain; Region: SLH; pfam00395 405534009941 Nuclease-related domain; Region: NERD; pfam08378 405534009942 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405534009943 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405534009944 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 405534009945 Walker A/P-loop; other site 405534009946 ATP binding site [chemical binding]; other site 405534009947 Q-loop/lid; other site 405534009948 ABC transporter signature motif; other site 405534009949 Walker B; other site 405534009950 D-loop; other site 405534009951 H-loop/switch region; other site 405534009952 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405534009953 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 405534009954 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534009955 Walker A/P-loop; other site 405534009956 ATP binding site [chemical binding]; other site 405534009957 Q-loop/lid; other site 405534009958 ABC transporter signature motif; other site 405534009959 Walker B; other site 405534009960 D-loop; other site 405534009961 H-loop/switch region; other site 405534009962 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 405534009963 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 405534009964 large terminase protein; Provisional; Region: 17; PHA02533 405534009965 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534009966 sequence-specific DNA binding site [nucleotide binding]; other site 405534009967 salt bridge; other site 405534009968 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405534009969 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 405534009970 active site 405534009971 DNA binding site [nucleotide binding] 405534009972 Int/Topo IB signature motif; other site 405534009973 hypothetical protein; Provisional; Region: PRK01844 405534009974 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 405534009975 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 405534009976 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 405534009977 TPP-binding site [chemical binding]; other site 405534009978 dimer interface [polypeptide binding]; other site 405534009979 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 405534009980 PYR/PP interface [polypeptide binding]; other site 405534009981 dimer interface [polypeptide binding]; other site 405534009982 TPP binding site [chemical binding]; other site 405534009983 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405534009984 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 405534009985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534009986 dimer interface [polypeptide binding]; other site 405534009987 conserved gate region; other site 405534009988 ABC-ATPase subunit interface; other site 405534009989 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 405534009990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534009991 dimer interface [polypeptide binding]; other site 405534009992 conserved gate region; other site 405534009993 ABC-ATPase subunit interface; other site 405534009994 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 405534009995 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 405534009996 Walker A/P-loop; other site 405534009997 ATP binding site [chemical binding]; other site 405534009998 Q-loop/lid; other site 405534009999 ABC transporter signature motif; other site 405534010000 Walker B; other site 405534010001 D-loop; other site 405534010002 H-loop/switch region; other site 405534010003 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 405534010004 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405534010005 membrane-bound complex binding site; other site 405534010006 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 405534010007 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 405534010008 active site 405534010009 metal binding site [ion binding]; metal-binding site 405534010010 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405534010011 hypothetical protein; Provisional; Region: PRK01546 405534010012 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405534010013 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 405534010014 catalytic residues [active] 405534010015 catalytic nucleophile [active] 405534010016 LexA repressor; Validated; Region: PRK00215 405534010017 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534010018 putative DNA binding site [nucleotide binding]; other site 405534010019 putative Zn2+ binding site [ion binding]; other site 405534010020 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 405534010021 Catalytic site [active] 405534010022 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 405534010023 Uncharacterized conserved protein [Function unknown]; Region: COG3595 405534010024 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 405534010025 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 405534010026 Predicted transcriptional regulators [Transcription]; Region: COG1695 405534010027 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405534010028 glutamine synthetase, type I; Region: GlnA; TIGR00653 405534010029 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 405534010030 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 405534010031 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 405534010032 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405534010033 DNA binding residues [nucleotide binding] 405534010034 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 405534010035 Aluminium resistance protein; Region: Alum_res; pfam06838 405534010036 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 405534010037 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 405534010038 HflX GTPase family; Region: HflX; cd01878 405534010039 G1 box; other site 405534010040 GTP/Mg2+ binding site [chemical binding]; other site 405534010041 Switch I region; other site 405534010042 G2 box; other site 405534010043 G3 box; other site 405534010044 Switch II region; other site 405534010045 G4 box; other site 405534010046 G5 box; other site 405534010047 Predicted membrane protein [Function unknown]; Region: COG2860 405534010048 UPF0126 domain; Region: UPF0126; pfam03458 405534010049 UPF0126 domain; Region: UPF0126; pfam03458 405534010050 stage V sporulation protein K; Region: spore_V_K; TIGR02881 405534010051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534010052 Walker A motif; other site 405534010053 ATP binding site [chemical binding]; other site 405534010054 Walker B motif; other site 405534010055 arginine finger; other site 405534010056 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 405534010057 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 405534010058 active site 405534010059 catalytic residues [active] 405534010060 DNA binding site [nucleotide binding] 405534010061 Int/Topo IB signature motif; other site 405534010062 bacterial Hfq-like; Region: Hfq; cd01716 405534010063 hexamer interface [polypeptide binding]; other site 405534010064 Sm1 motif; other site 405534010065 RNA binding site [nucleotide binding]; other site 405534010066 Sm2 motif; other site 405534010067 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 405534010068 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 405534010069 Bacterial SH3 domain; Region: SH3_3; pfam08239 405534010070 Bacterial SH3 domain; Region: SH3_3; pfam08239 405534010071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 405534010072 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 405534010073 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 405534010074 active site 405534010075 phosphorylation site [posttranslational modification] 405534010076 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 405534010077 active site 405534010078 P-loop; other site 405534010079 phosphorylation site [posttranslational modification] 405534010080 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 405534010081 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 405534010082 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 405534010083 putative substrate binding site [chemical binding]; other site 405534010084 putative ATP binding site [chemical binding]; other site 405534010085 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 405534010086 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 405534010087 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405534010088 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 405534010089 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 405534010090 dimer interface [polypeptide binding]; other site 405534010091 active site 405534010092 metal binding site [ion binding]; metal-binding site 405534010093 Predicted membrane protein [Function unknown]; Region: COG2322 405534010094 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 405534010095 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 405534010096 Glyco_18 domain; Region: Glyco_18; smart00636 405534010097 putative active site [active] 405534010098 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 405534010099 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405534010100 putative active site [active] 405534010101 putative metal binding site [ion binding]; other site 405534010102 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 405534010103 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 405534010104 IHF dimer interface [polypeptide binding]; other site 405534010105 IHF - DNA interface [nucleotide binding]; other site 405534010106 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 405534010107 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405534010108 metal-binding site [ion binding] 405534010109 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 405534010110 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405534010111 metal-binding site [ion binding] 405534010112 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405534010113 Soluble P-type ATPase [General function prediction only]; Region: COG4087 405534010114 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 405534010115 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405534010116 metal-binding site [ion binding] 405534010117 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 405534010118 putative homodimer interface [polypeptide binding]; other site 405534010119 putative homotetramer interface [polypeptide binding]; other site 405534010120 putative allosteric switch controlling residues; other site 405534010121 putative metal binding site [ion binding]; other site 405534010122 putative homodimer-homodimer interface [polypeptide binding]; other site 405534010123 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 405534010124 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405534010125 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405534010126 Walker A/P-loop; other site 405534010127 ATP binding site [chemical binding]; other site 405534010128 Q-loop/lid; other site 405534010129 ABC transporter signature motif; other site 405534010130 Walker B; other site 405534010131 D-loop; other site 405534010132 H-loop/switch region; other site 405534010133 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405534010134 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405534010135 ABC-ATPase subunit interface; other site 405534010136 dimer interface [polypeptide binding]; other site 405534010137 putative PBP binding regions; other site 405534010138 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405534010139 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405534010140 ABC-ATPase subunit interface; other site 405534010141 dimer interface [polypeptide binding]; other site 405534010142 putative PBP binding regions; other site 405534010143 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405534010144 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 405534010145 putative ligand binding residues [chemical binding]; other site 405534010146 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 405534010147 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 405534010148 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405534010149 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405534010150 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 405534010151 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 405534010152 DNA binding site [nucleotide binding] 405534010153 active site 405534010154 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 405534010155 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 405534010156 endonuclease III; Region: ENDO3c; smart00478 405534010157 minor groove reading motif; other site 405534010158 helix-hairpin-helix signature motif; other site 405534010159 substrate binding pocket [chemical binding]; other site 405534010160 active site 405534010161 peptidase T; Region: peptidase-T; TIGR01882 405534010162 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 405534010163 metal binding site [ion binding]; metal-binding site 405534010164 dimer interface [polypeptide binding]; other site 405534010165 Predicted membrane protein [Function unknown]; Region: COG2364 405534010166 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405534010167 hypothetical protein; Provisional; Region: PRK06764 405534010168 PAS domain S-box; Region: sensory_box; TIGR00229 405534010169 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405534010170 putative active site [active] 405534010171 heme pocket [chemical binding]; other site 405534010172 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405534010173 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405534010174 metal binding site [ion binding]; metal-binding site 405534010175 active site 405534010176 I-site; other site 405534010177 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405534010178 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 405534010179 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 405534010180 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405534010181 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405534010182 DNA-binding site [nucleotide binding]; DNA binding site 405534010183 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405534010184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534010185 homodimer interface [polypeptide binding]; other site 405534010186 catalytic residue [active] 405534010187 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 405534010188 active site 405534010189 catalytic site [active] 405534010190 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405534010191 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 405534010192 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405534010193 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 405534010194 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 405534010195 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 405534010196 Sulfatase; Region: Sulfatase; pfam00884 405534010197 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405534010198 binding surface 405534010199 Tetratricopeptide repeat; Region: TPR_16; pfam13432 405534010200 TPR motif; other site 405534010201 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 405534010202 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 405534010203 G1 box; other site 405534010204 GTP/Mg2+ binding site [chemical binding]; other site 405534010205 Switch I region; other site 405534010206 G3 box; other site 405534010207 Switch II region; other site 405534010208 G4 box; other site 405534010209 G5 box; other site 405534010210 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 405534010211 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 405534010212 active site 405534010213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534010214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534010215 dimer interface [polypeptide binding]; other site 405534010216 phosphorylation site [posttranslational modification] 405534010217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534010218 ATP binding site [chemical binding]; other site 405534010219 Mg2+ binding site [ion binding]; other site 405534010220 G-X-G motif; other site 405534010221 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534010222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534010223 active site 405534010224 phosphorylation site [posttranslational modification] 405534010225 intermolecular recognition site; other site 405534010226 dimerization interface [polypeptide binding]; other site 405534010227 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534010228 DNA binding site [nucleotide binding] 405534010229 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 405534010230 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405534010231 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 405534010232 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405534010233 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 405534010234 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 405534010235 Walker A/P-loop; other site 405534010236 ATP binding site [chemical binding]; other site 405534010237 Q-loop/lid; other site 405534010238 ABC transporter signature motif; other site 405534010239 Walker B; other site 405534010240 D-loop; other site 405534010241 H-loop/switch region; other site 405534010242 Short C-terminal domain; Region: SHOCT; pfam09851 405534010243 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 405534010244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534010245 ATP binding site [chemical binding]; other site 405534010246 Mg2+ binding site [ion binding]; other site 405534010247 G-X-G motif; other site 405534010248 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 405534010249 ATP binding site [chemical binding]; other site 405534010250 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 405534010251 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 405534010252 MutS domain I; Region: MutS_I; pfam01624 405534010253 MutS domain II; Region: MutS_II; pfam05188 405534010254 MutS domain III; Region: MutS_III; pfam05192 405534010255 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 405534010256 Walker A/P-loop; other site 405534010257 ATP binding site [chemical binding]; other site 405534010258 Q-loop/lid; other site 405534010259 ABC transporter signature motif; other site 405534010260 Walker B; other site 405534010261 D-loop; other site 405534010262 H-loop/switch region; other site 405534010263 Outer spore coat protein E (CotE); Region: CotE; pfam10628 405534010264 Predicted membrane protein [Function unknown]; Region: COG4550 405534010265 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 405534010266 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 405534010267 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405534010268 FeS/SAM binding site; other site 405534010269 TRAM domain; Region: TRAM; pfam01938 405534010270 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 405534010271 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 405534010272 TPP-binding site [chemical binding]; other site 405534010273 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 405534010274 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 405534010275 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 405534010276 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 405534010277 dimer interface [polypeptide binding]; other site 405534010278 PYR/PP interface [polypeptide binding]; other site 405534010279 TPP binding site [chemical binding]; other site 405534010280 substrate binding site [chemical binding]; other site 405534010281 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405534010282 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 405534010283 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 405534010284 active site 405534010285 dimer interface [polypeptide binding]; other site 405534010286 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 405534010287 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 405534010288 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405534010289 putative active site [active] 405534010290 metal binding site [ion binding]; metal-binding site 405534010291 homodimer binding site [polypeptide binding]; other site 405534010292 phosphodiesterase; Provisional; Region: PRK12704 405534010293 Uncharacterized conserved protein [Function unknown]; Region: COG3334 405534010294 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405534010295 Zn2+ binding site [ion binding]; other site 405534010296 Mg2+ binding site [ion binding]; other site 405534010297 recA bacterial DNA recombination protein; Region: RecA; cl17211 405534010298 recA bacterial DNA recombination protein; Region: RecA; cl17211 405534010299 competence damage-inducible protein A; Provisional; Region: PRK00549 405534010300 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 405534010301 putative MPT binding site; other site 405534010302 Competence-damaged protein; Region: CinA; pfam02464 405534010303 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 405534010304 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 405534010305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534010306 non-specific DNA binding site [nucleotide binding]; other site 405534010307 salt bridge; other site 405534010308 sequence-specific DNA binding site [nucleotide binding]; other site 405534010309 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 405534010310 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 405534010311 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 405534010312 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 405534010313 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 405534010314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405534010315 NAD(P) binding site [chemical binding]; other site 405534010316 active site 405534010317 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 405534010318 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 405534010319 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 405534010320 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 405534010321 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 405534010322 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405534010323 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 405534010324 TM-ABC transporter signature motif; other site 405534010325 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405534010326 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 405534010327 TM-ABC transporter signature motif; other site 405534010328 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 405534010329 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 405534010330 Walker A/P-loop; other site 405534010331 ATP binding site [chemical binding]; other site 405534010332 Q-loop/lid; other site 405534010333 ABC transporter signature motif; other site 405534010334 Walker B; other site 405534010335 D-loop; other site 405534010336 H-loop/switch region; other site 405534010337 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405534010338 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 405534010339 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 405534010340 ligand binding site [chemical binding]; other site 405534010341 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 405534010342 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405534010343 DNA-binding site [nucleotide binding]; DNA binding site 405534010344 UTRA domain; Region: UTRA; pfam07702 405534010345 Tetraspanin family; Region: Tetraspannin; pfam00335 405534010346 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 405534010347 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 405534010348 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 405534010349 YlzJ-like protein; Region: YlzJ; pfam14035 405534010350 Clp protease; Region: CLP_protease; pfam00574 405534010351 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 405534010352 active site 405534010353 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 405534010354 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405534010355 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 405534010356 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 405534010357 dihydrodipicolinate synthase; Region: dapA; TIGR00674 405534010358 dimer interface [polypeptide binding]; other site 405534010359 active site 405534010360 catalytic residue [active] 405534010361 aspartate kinase I; Reviewed; Region: PRK08210 405534010362 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 405534010363 nucleotide binding site [chemical binding]; other site 405534010364 substrate binding site [chemical binding]; other site 405534010365 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 405534010366 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 405534010367 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 405534010368 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 405534010369 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 405534010370 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 405534010371 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 405534010372 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 405534010373 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 405534010374 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 405534010375 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 405534010376 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 405534010377 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 405534010378 NodB motif; other site 405534010379 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 405534010380 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 405534010381 RNase E interface [polypeptide binding]; other site 405534010382 trimer interface [polypeptide binding]; other site 405534010383 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 405534010384 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 405534010385 RNase E interface [polypeptide binding]; other site 405534010386 trimer interface [polypeptide binding]; other site 405534010387 active site 405534010388 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 405534010389 putative nucleic acid binding region [nucleotide binding]; other site 405534010390 G-X-X-G motif; other site 405534010391 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 405534010392 RNA binding site [nucleotide binding]; other site 405534010393 domain interface; other site 405534010394 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 405534010395 16S/18S rRNA binding site [nucleotide binding]; other site 405534010396 S13e-L30e interaction site [polypeptide binding]; other site 405534010397 25S rRNA binding site [nucleotide binding]; other site 405534010398 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 405534010399 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 405534010400 active site 405534010401 Riboflavin kinase; Region: Flavokinase; smart00904 405534010402 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 405534010403 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 405534010404 RNA binding site [nucleotide binding]; other site 405534010405 active site 405534010406 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 405534010407 Protein of unknown function (DUF503); Region: DUF503; pfam04456 405534010408 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 405534010409 translation initiation factor IF-2; Region: IF-2; TIGR00487 405534010410 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 405534010411 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 405534010412 G1 box; other site 405534010413 putative GEF interaction site [polypeptide binding]; other site 405534010414 GTP/Mg2+ binding site [chemical binding]; other site 405534010415 Switch I region; other site 405534010416 G2 box; other site 405534010417 G3 box; other site 405534010418 Switch II region; other site 405534010419 G4 box; other site 405534010420 G5 box; other site 405534010421 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 405534010422 Translation-initiation factor 2; Region: IF-2; pfam11987 405534010423 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 405534010424 hypothetical protein; Provisional; Region: PRK07714 405534010425 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 405534010426 putative RNA binding cleft [nucleotide binding]; other site 405534010427 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 405534010428 NusA N-terminal domain; Region: NusA_N; pfam08529 405534010429 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 405534010430 RNA binding site [nucleotide binding]; other site 405534010431 homodimer interface [polypeptide binding]; other site 405534010432 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 405534010433 G-X-X-G motif; other site 405534010434 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 405534010435 G-X-X-G motif; other site 405534010436 ribosome maturation protein RimP; Reviewed; Region: PRK00092 405534010437 Sm and related proteins; Region: Sm_like; cl00259 405534010438 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 405534010439 putative oligomer interface [polypeptide binding]; other site 405534010440 putative RNA binding site [nucleotide binding]; other site 405534010441 DNA polymerase III PolC; Validated; Region: polC; PRK00448 405534010442 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 405534010443 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 405534010444 generic binding surface II; other site 405534010445 generic binding surface I; other site 405534010446 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 405534010447 active site 405534010448 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 405534010449 active site 405534010450 catalytic site [active] 405534010451 substrate binding site [chemical binding]; other site 405534010452 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 405534010453 prolyl-tRNA synthetase; Provisional; Region: PRK09194 405534010454 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 405534010455 dimer interface [polypeptide binding]; other site 405534010456 motif 1; other site 405534010457 active site 405534010458 motif 2; other site 405534010459 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 405534010460 putative deacylase active site [active] 405534010461 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 405534010462 active site 405534010463 motif 3; other site 405534010464 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 405534010465 anticodon binding site; other site 405534010466 RIP metalloprotease RseP; Region: TIGR00054 405534010467 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 405534010468 active site 405534010469 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 405534010470 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 405534010471 protein binding site [polypeptide binding]; other site 405534010472 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 405534010473 putative substrate binding region [chemical binding]; other site 405534010474 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 405534010475 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 405534010476 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 405534010477 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 405534010478 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 405534010479 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 405534010480 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 405534010481 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 405534010482 catalytic residue [active] 405534010483 putative FPP diphosphate binding site; other site 405534010484 putative FPP binding hydrophobic cleft; other site 405534010485 dimer interface [polypeptide binding]; other site 405534010486 putative IPP diphosphate binding site; other site 405534010487 ribosome recycling factor; Reviewed; Region: frr; PRK00083 405534010488 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 405534010489 hinge region; other site 405534010490 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 405534010491 putative nucleotide binding site [chemical binding]; other site 405534010492 uridine monophosphate binding site [chemical binding]; other site 405534010493 homohexameric interface [polypeptide binding]; other site 405534010494 elongation factor Ts; Provisional; Region: tsf; PRK09377 405534010495 UBA/TS-N domain; Region: UBA; pfam00627 405534010496 Elongation factor TS; Region: EF_TS; pfam00889 405534010497 Elongation factor TS; Region: EF_TS; pfam00889 405534010498 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 405534010499 rRNA interaction site [nucleotide binding]; other site 405534010500 S8 interaction site; other site 405534010501 putative laminin-1 binding site; other site 405534010502 transcriptional repressor CodY; Validated; Region: PRK04158 405534010503 CodY GAF-like domain; Region: CodY; pfam06018 405534010504 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 405534010505 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 405534010506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534010507 Walker A motif; other site 405534010508 ATP binding site [chemical binding]; other site 405534010509 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 405534010510 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 405534010511 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 405534010512 active site 405534010513 HslU subunit interaction site [polypeptide binding]; other site 405534010514 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 405534010515 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 405534010516 active site 405534010517 Int/Topo IB signature motif; other site 405534010518 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 405534010519 Glucose inhibited division protein A; Region: GIDA; pfam01134 405534010520 DNA topoisomerase I; Validated; Region: PRK05582 405534010521 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 405534010522 active site 405534010523 interdomain interaction site; other site 405534010524 putative metal-binding site [ion binding]; other site 405534010525 nucleotide binding site [chemical binding]; other site 405534010526 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 405534010527 domain I; other site 405534010528 DNA binding groove [nucleotide binding] 405534010529 phosphate binding site [ion binding]; other site 405534010530 domain II; other site 405534010531 domain III; other site 405534010532 nucleotide binding site [chemical binding]; other site 405534010533 catalytic site [active] 405534010534 domain IV; other site 405534010535 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 405534010536 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 405534010537 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 405534010538 DNA protecting protein DprA; Region: dprA; TIGR00732 405534010539 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 405534010540 CoA binding domain; Region: CoA_binding; smart00881 405534010541 CoA-ligase; Region: Ligase_CoA; pfam00549 405534010542 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 405534010543 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 405534010544 CoA-ligase; Region: Ligase_CoA; pfam00549 405534010545 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 405534010546 RNA/DNA hybrid binding site [nucleotide binding]; other site 405534010547 active site 405534010548 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 405534010549 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 405534010550 GTP/Mg2+ binding site [chemical binding]; other site 405534010551 G4 box; other site 405534010552 G5 box; other site 405534010553 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 405534010554 G1 box; other site 405534010555 G1 box; other site 405534010556 GTP/Mg2+ binding site [chemical binding]; other site 405534010557 Switch I region; other site 405534010558 G2 box; other site 405534010559 G2 box; other site 405534010560 G3 box; other site 405534010561 G3 box; other site 405534010562 Switch II region; other site 405534010563 Switch II region; other site 405534010564 G4 box; other site 405534010565 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405534010566 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405534010567 Catalytic site [active] 405534010568 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405534010569 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 405534010570 Ribosomal protein L19 leader 405534010571 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 405534010572 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 405534010573 RimM N-terminal domain; Region: RimM; pfam01782 405534010574 PRC-barrel domain; Region: PRC; pfam05239 405534010575 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 405534010576 KH domain; Region: KH_4; pfam13083 405534010577 G-X-X-G motif; other site 405534010578 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 405534010579 signal recognition particle protein; Provisional; Region: PRK10867 405534010580 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 405534010581 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 405534010582 P loop; other site 405534010583 GTP binding site [chemical binding]; other site 405534010584 Signal peptide binding domain; Region: SRP_SPB; pfam02978 405534010585 putative DNA-binding protein; Validated; Region: PRK00118 405534010586 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 405534010587 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 405534010588 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 405534010589 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 405534010590 P loop; other site 405534010591 GTP binding site [chemical binding]; other site 405534010592 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 405534010593 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 405534010594 Walker A/P-loop; other site 405534010595 ATP binding site [chemical binding]; other site 405534010596 Q-loop/lid; other site 405534010597 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 405534010598 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 405534010599 ABC transporter signature motif; other site 405534010600 Walker B; other site 405534010601 D-loop; other site 405534010602 H-loop/switch region; other site 405534010603 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 405534010604 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 405534010605 dimerization interface [polypeptide binding]; other site 405534010606 active site 405534010607 metal binding site [ion binding]; metal-binding site 405534010608 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 405534010609 dsRNA binding site [nucleotide binding]; other site 405534010610 acyl carrier protein; Provisional; Region: acpP; PRK00982 405534010611 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 405534010612 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 405534010613 NAD(P) binding site [chemical binding]; other site 405534010614 homotetramer interface [polypeptide binding]; other site 405534010615 homodimer interface [polypeptide binding]; other site 405534010616 active site 405534010617 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 405534010618 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 405534010619 putative phosphate acyltransferase; Provisional; Region: PRK05331 405534010620 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 405534010621 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 405534010622 active site 2 [active] 405534010623 active site 1 [active] 405534010624 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 405534010625 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 405534010626 generic binding surface II; other site 405534010627 ssDNA binding site; other site 405534010628 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405534010629 ATP binding site [chemical binding]; other site 405534010630 putative Mg++ binding site [ion binding]; other site 405534010631 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405534010632 nucleotide binding region [chemical binding]; other site 405534010633 ATP-binding site [chemical binding]; other site 405534010634 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 405534010635 DAK2 domain; Region: Dak2; pfam02734 405534010636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 405534010637 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 405534010638 Thiamine pyrophosphokinase; Region: TPK; cd07995 405534010639 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 405534010640 active site 405534010641 dimerization interface [polypeptide binding]; other site 405534010642 thiamine binding site [chemical binding]; other site 405534010643 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 405534010644 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 405534010645 substrate binding site [chemical binding]; other site 405534010646 hexamer interface [polypeptide binding]; other site 405534010647 metal binding site [ion binding]; metal-binding site 405534010648 GTPase RsgA; Reviewed; Region: PRK00098 405534010649 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 405534010650 RNA binding site [nucleotide binding]; other site 405534010651 homodimer interface [polypeptide binding]; other site 405534010652 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 405534010653 GTPase/Zn-binding domain interface [polypeptide binding]; other site 405534010654 GTP/Mg2+ binding site [chemical binding]; other site 405534010655 G4 box; other site 405534010656 G5 box; other site 405534010657 G1 box; other site 405534010658 Switch I region; other site 405534010659 G2 box; other site 405534010660 G3 box; other site 405534010661 Switch II region; other site 405534010662 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 405534010663 Catalytic domain of Protein Kinases; Region: PKc; cd00180 405534010664 active site 405534010665 ATP binding site [chemical binding]; other site 405534010666 substrate binding site [chemical binding]; other site 405534010667 activation loop (A-loop); other site 405534010668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 405534010669 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 405534010670 PASTA domain; Region: PASTA; pfam03793 405534010671 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 405534010672 Protein phosphatase 2C; Region: PP2C; pfam00481 405534010673 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 405534010674 active site 405534010675 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 405534010676 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405534010677 FeS/SAM binding site; other site 405534010678 16S rRNA methyltransferase B; Provisional; Region: PRK14902 405534010679 NusB family; Region: NusB; pfam01029 405534010680 putative RNA binding site [nucleotide binding]; other site 405534010681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534010682 S-adenosylmethionine binding site [chemical binding]; other site 405534010683 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 405534010684 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 405534010685 putative active site [active] 405534010686 substrate binding site [chemical binding]; other site 405534010687 putative cosubstrate binding site; other site 405534010688 catalytic site [active] 405534010689 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 405534010690 substrate binding site [chemical binding]; other site 405534010691 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 405534010692 active site 405534010693 catalytic residues [active] 405534010694 metal binding site [ion binding]; metal-binding site 405534010695 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405534010696 primosomal protein N' Region: priA; TIGR00595 405534010697 ATP binding site [chemical binding]; other site 405534010698 putative Mg++ binding site [ion binding]; other site 405534010699 helicase superfamily c-terminal domain; Region: HELICc; smart00490 405534010700 nucleotide binding region [chemical binding]; other site 405534010701 ATP-binding site [chemical binding]; other site 405534010702 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 405534010703 Flavoprotein; Region: Flavoprotein; pfam02441 405534010704 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 405534010705 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 405534010706 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 405534010707 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 405534010708 catalytic site [active] 405534010709 G-X2-G-X-G-K; other site 405534010710 hypothetical protein; Provisional; Region: PRK04323 405534010711 hypothetical protein; Provisional; Region: PRK11820 405534010712 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 405534010713 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 405534010714 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 405534010715 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 405534010716 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405534010717 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 405534010718 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534010719 motif II; other site 405534010720 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 405534010721 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 405534010722 Domain of unknown function (DUF814); Region: DUF814; pfam05670 405534010723 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 405534010724 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 405534010725 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 405534010726 active site 405534010727 DinB family; Region: DinB; cl17821 405534010728 DinB superfamily; Region: DinB_2; pfam12867 405534010729 YoqO-like protein; Region: YoqO; pfam14037 405534010730 YoqO-like protein; Region: YoqO; pfam14037 405534010731 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 405534010732 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 405534010733 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 405534010734 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534010735 motif II; other site 405534010736 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405534010737 active site 405534010738 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 405534010739 active site 405534010740 dimer interface [polypeptide binding]; other site 405534010741 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 405534010742 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 405534010743 heterodimer interface [polypeptide binding]; other site 405534010744 active site 405534010745 FMN binding site [chemical binding]; other site 405534010746 homodimer interface [polypeptide binding]; other site 405534010747 substrate binding site [chemical binding]; other site 405534010748 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 405534010749 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 405534010750 FAD binding pocket [chemical binding]; other site 405534010751 FAD binding motif [chemical binding]; other site 405534010752 phosphate binding motif [ion binding]; other site 405534010753 beta-alpha-beta structure motif; other site 405534010754 NAD binding pocket [chemical binding]; other site 405534010755 Iron coordination center [ion binding]; other site 405534010756 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 405534010757 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405534010758 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 405534010759 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 405534010760 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405534010761 ATP-grasp domain; Region: ATP-grasp_4; cl17255 405534010762 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 405534010763 IMP binding site; other site 405534010764 dimer interface [polypeptide binding]; other site 405534010765 interdomain contacts; other site 405534010766 partial ornithine binding site; other site 405534010767 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 405534010768 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 405534010769 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 405534010770 catalytic site [active] 405534010771 subunit interface [polypeptide binding]; other site 405534010772 dihydroorotase; Validated; Region: pyrC; PRK09357 405534010773 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 405534010774 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 405534010775 active site 405534010776 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 405534010777 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 405534010778 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 405534010779 PyrR binding site 405534010780 uracil transporter; Provisional; Region: PRK10720 405534010781 PyrR binding site 405534010782 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 405534010783 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405534010784 active site 405534010785 PyrR binding site 405534010786 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 405534010787 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405534010788 RNA binding surface [nucleotide binding]; other site 405534010789 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 405534010790 active site 405534010791 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 405534010792 lipoprotein signal peptidase; Provisional; Region: PRK14787 405534010793 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 405534010794 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 405534010795 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 405534010796 active site 405534010797 HIGH motif; other site 405534010798 nucleotide binding site [chemical binding]; other site 405534010799 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 405534010800 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 405534010801 active site 405534010802 KMSKS motif; other site 405534010803 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 405534010804 tRNA binding surface [nucleotide binding]; other site 405534010805 anticodon binding site; other site 405534010806 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 405534010807 DivIVA protein; Region: DivIVA; pfam05103 405534010808 DivIVA domain; Region: DivI1A_domain; TIGR03544 405534010809 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 405534010810 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 405534010811 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405534010812 RNA binding surface [nucleotide binding]; other site 405534010813 YGGT family; Region: YGGT; pfam02325 405534010814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 405534010815 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 405534010816 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405534010817 catalytic residue [active] 405534010818 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 405534010819 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 405534010820 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 405534010821 sporulation sigma factor SigG; Reviewed; Region: PRK08215 405534010822 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405534010823 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405534010824 DNA binding residues [nucleotide binding] 405534010825 sporulation sigma factor SigE; Reviewed; Region: PRK08301 405534010826 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405534010827 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405534010828 DNA binding residues [nucleotide binding] 405534010829 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 405534010830 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 405534010831 cell division protein FtsZ; Validated; Region: PRK09330 405534010832 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 405534010833 nucleotide binding site [chemical binding]; other site 405534010834 SulA interaction site; other site 405534010835 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 405534010836 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405534010837 nucleotide binding site [chemical binding]; other site 405534010838 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 405534010839 Cell division protein FtsA; Region: FtsA; pfam14450 405534010840 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 405534010841 Cell division protein FtsQ; Region: FtsQ; pfam03799 405534010842 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 405534010843 FAD binding domain; Region: FAD_binding_4; pfam01565 405534010844 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 405534010845 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 405534010846 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 405534010847 active site 405534010848 homodimer interface [polypeptide binding]; other site 405534010849 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 405534010850 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 405534010851 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 405534010852 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405534010853 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405534010854 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 405534010855 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 405534010856 Mg++ binding site [ion binding]; other site 405534010857 putative catalytic motif [active] 405534010858 putative substrate binding site [chemical binding]; other site 405534010859 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 405534010860 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 405534010861 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405534010862 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405534010863 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 405534010864 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405534010865 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405534010866 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 405534010867 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405534010868 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405534010869 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405534010870 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 405534010871 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 405534010872 Cell division protein FtsL; Region: FtsL; cl11433 405534010873 MraW methylase family; Region: Methyltransf_5; pfam01795 405534010874 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 405534010875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 405534010876 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 405534010877 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 405534010878 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 405534010879 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 405534010880 hypothetical protein; Provisional; Region: PRK13688 405534010881 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 405534010882 Coenzyme A binding pocket [chemical binding]; other site 405534010883 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 405534010884 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 405534010885 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 405534010886 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 405534010887 Replication-relaxation; Region: Replic_Relax; pfam13814 405534010888 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 405534010889 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534010890 non-specific DNA binding site [nucleotide binding]; other site 405534010891 salt bridge; other site 405534010892 sequence-specific DNA binding site [nucleotide binding]; other site 405534010893 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405534010894 active site 405534010895 metal binding site [ion binding]; metal-binding site 405534010896 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 405534010897 Phage lysis protein, holin; Region: Phage_holin; cl04675 405534010898 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 405534010899 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 405534010900 active site 405534010901 catalytic residues [active] 405534010902 DNA binding site [nucleotide binding] 405534010903 Int/Topo IB signature motif; other site 405534010904 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 405534010905 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 405534010906 Phage tail protein; Region: Sipho_tail; cl17486 405534010907 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 405534010908 linker region; other site 405534010909 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 405534010910 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 405534010911 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 405534010912 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 405534010913 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 405534010914 oligomerization interface [polypeptide binding]; other site 405534010915 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 405534010916 Phage capsid family; Region: Phage_capsid; pfam05065 405534010917 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 405534010918 oligomer interface [polypeptide binding]; other site 405534010919 Clp protease; Region: CLP_protease; pfam00574 405534010920 active site residues [active] 405534010921 Phage-related protein [Function unknown]; Region: COG4695; cl01923 405534010922 Phage portal protein; Region: Phage_portal; pfam04860 405534010923 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 405534010924 Phage terminase, small subunit; Region: Terminase_4; cl01525 405534010925 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 405534010926 Int/Topo IB signature motif; other site 405534010927 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 405534010928 Protein of unknown function (DUF3983); Region: DUF3983; pfam13137 405534010929 YopX protein; Region: YopX; pfam09643 405534010930 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 405534010931 putative metal binding site [ion binding]; other site 405534010932 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 405534010933 hypothetical protein; Validated; Region: PRK08116 405534010934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534010935 Walker A motif; other site 405534010936 ATP binding site [chemical binding]; other site 405534010937 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 405534010938 Helix-turn-helix domain; Region: HTH_17; pfam12728 405534010939 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534010940 non-specific DNA binding site [nucleotide binding]; other site 405534010941 salt bridge; other site 405534010942 sequence-specific DNA binding site [nucleotide binding]; other site 405534010943 transcriptional repressor DicA; Reviewed; Region: PRK09706 405534010944 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534010945 non-specific DNA binding site [nucleotide binding]; other site 405534010946 salt bridge; other site 405534010947 sequence-specific DNA binding site [nucleotide binding]; other site 405534010948 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405534010949 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534010950 non-specific DNA binding site [nucleotide binding]; other site 405534010951 salt bridge; other site 405534010952 sequence-specific DNA binding site [nucleotide binding]; other site 405534010953 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 405534010954 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 405534010955 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 405534010956 Int/Topo IB signature motif; other site 405534010957 hypothetical protein; Provisional; Region: PRK13670 405534010958 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 405534010959 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 405534010960 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 405534010961 protein binding site [polypeptide binding]; other site 405534010962 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 405534010963 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 405534010964 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 405534010965 active site 405534010966 nucleophile elbow; other site 405534010967 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 405534010968 Nucleoside recognition; Region: Gate; pfam07670 405534010969 Nucleoside recognition; Region: Gate; pfam07670 405534010970 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 405534010971 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 405534010972 active site 405534010973 (T/H)XGH motif; other site 405534010974 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 405534010975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534010976 S-adenosylmethionine binding site [chemical binding]; other site 405534010977 ylbH leader 405534010978 putative transposase OrfB; Reviewed; Region: PHA02517 405534010979 HTH-like domain; Region: HTH_21; pfam13276 405534010980 Integrase core domain; Region: rve; pfam00665 405534010981 Integrase core domain; Region: rve_2; pfam13333 405534010982 Homeodomain-like domain; Region: HTH_23; pfam13384 405534010983 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 405534010984 Protein of unknown function (DUF964); Region: DUF964; pfam06133 405534010985 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405534010986 catalytic core [active] 405534010987 YlbE-like protein; Region: YlbE; pfam14003 405534010988 Putative coat protein; Region: YlbD_coat; pfam14071 405534010989 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 405534010990 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 405534010991 YugN-like family; Region: YugN; pfam08868 405534010992 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 405534010993 active site 405534010994 catalytic triad [active] 405534010995 dimer interface [polypeptide binding]; other site 405534010996 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 405534010997 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 405534010998 putative active site [active] 405534010999 putative NTP binding site [chemical binding]; other site 405534011000 putative nucleic acid binding site [nucleotide binding]; other site 405534011001 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 405534011002 active site 405534011003 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 405534011004 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 405534011005 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 405534011006 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 405534011007 Subunit I/III interface [polypeptide binding]; other site 405534011008 Subunit III/IV interface [polypeptide binding]; other site 405534011009 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 405534011010 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 405534011011 D-pathway; other site 405534011012 Putative ubiquinol binding site [chemical binding]; other site 405534011013 Low-spin heme (heme b) binding site [chemical binding]; other site 405534011014 Putative water exit pathway; other site 405534011015 Binuclear center (heme o3/CuB) [ion binding]; other site 405534011016 K-pathway; other site 405534011017 Putative proton exit pathway; other site 405534011018 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 405534011019 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 405534011020 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 405534011021 Cytochrome c; Region: Cytochrom_C; pfam00034 405534011022 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 405534011023 UbiA prenyltransferase family; Region: UbiA; pfam01040 405534011024 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 405534011025 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 405534011026 pyruvate carboxylase; Reviewed; Region: PRK12999 405534011027 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405534011028 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 405534011029 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 405534011030 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 405534011031 active site 405534011032 catalytic residues [active] 405534011033 metal binding site [ion binding]; metal-binding site 405534011034 homodimer binding site [polypeptide binding]; other site 405534011035 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 405534011036 carboxyltransferase (CT) interaction site; other site 405534011037 biotinylation site [posttranslational modification]; other site 405534011038 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 405534011039 hypothetical protein; Provisional; Region: PRK13666 405534011040 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 405534011041 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 405534011042 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 405534011043 putative active site [active] 405534011044 PhoH-like protein; Region: PhoH; pfam02562 405534011045 hypothetical protein; Provisional; Region: PRK06733 405534011046 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 405534011047 YlaH-like protein; Region: YlaH; pfam14036 405534011048 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 405534011049 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 405534011050 G1 box; other site 405534011051 putative GEF interaction site [polypeptide binding]; other site 405534011052 GTP/Mg2+ binding site [chemical binding]; other site 405534011053 Switch I region; other site 405534011054 G2 box; other site 405534011055 G3 box; other site 405534011056 Switch II region; other site 405534011057 G4 box; other site 405534011058 G5 box; other site 405534011059 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 405534011060 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 405534011061 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 405534011062 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 405534011063 active site 405534011064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 405534011065 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 405534011066 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 405534011067 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 405534011068 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 405534011069 homodimer interface [polypeptide binding]; other site 405534011070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534011071 catalytic residue [active] 405534011072 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 405534011073 transglutaminase; Provisional; Region: tgl; PRK03187 405534011074 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 405534011075 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 405534011076 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 405534011077 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 405534011078 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 405534011079 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 405534011080 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405534011081 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405534011082 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 405534011083 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405534011084 E3 interaction surface; other site 405534011085 lipoyl attachment site [posttranslational modification]; other site 405534011086 e3 binding domain; Region: E3_binding; pfam02817 405534011087 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 405534011088 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 405534011089 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 405534011090 alpha subunit interface [polypeptide binding]; other site 405534011091 TPP binding site [chemical binding]; other site 405534011092 heterodimer interface [polypeptide binding]; other site 405534011093 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405534011094 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 405534011095 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 405534011096 TPP-binding site [chemical binding]; other site 405534011097 heterodimer interface [polypeptide binding]; other site 405534011098 tetramer interface [polypeptide binding]; other site 405534011099 phosphorylation loop region [posttranslational modification] 405534011100 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 405534011101 active site 405534011102 catalytic residues [active] 405534011103 metal binding site [ion binding]; metal-binding site 405534011104 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534011105 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405534011106 active site 405534011107 motif I; other site 405534011108 motif II; other site 405534011109 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534011110 hypothetical protein; Provisional; Region: PRK13667 405534011111 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 405534011112 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405534011113 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 405534011114 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 405534011115 TrkA-N domain; Region: TrkA_N; pfam02254 405534011116 TrkA-C domain; Region: TrkA_C; pfam02080 405534011117 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 405534011118 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405534011119 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 405534011120 metal binding site [ion binding]; metal-binding site 405534011121 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 405534011122 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 405534011123 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 405534011124 trimer interface [polypeptide binding]; other site 405534011125 active site 405534011126 substrate binding site [chemical binding]; other site 405534011127 CoA binding site [chemical binding]; other site 405534011128 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405534011129 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405534011130 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405534011131 dimerization interface [polypeptide binding]; other site 405534011132 FOG: CBS domain [General function prediction only]; Region: COG0517 405534011133 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 405534011134 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 405534011135 Protein of unknown function (DUF458); Region: DUF458; pfam04308 405534011136 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 405534011137 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 405534011138 catalytic residues [active] 405534011139 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 405534011140 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405534011141 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 405534011142 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 405534011143 short chain dehydrogenase; Provisional; Region: PRK07677 405534011144 NAD(P) binding site [chemical binding]; other site 405534011145 substrate binding site [chemical binding]; other site 405534011146 homotetramer interface [polypeptide binding]; other site 405534011147 active site 405534011148 homodimer interface [polypeptide binding]; other site 405534011149 phosphodiesterase YaeI; Provisional; Region: PRK11340 405534011150 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 405534011151 putative active site [active] 405534011152 putative metal binding site [ion binding]; other site 405534011153 polyphosphate kinase; Provisional; Region: PRK05443 405534011154 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 405534011155 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 405534011156 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 405534011157 putative domain interface [polypeptide binding]; other site 405534011158 putative active site [active] 405534011159 catalytic site [active] 405534011160 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 405534011161 putative domain interface [polypeptide binding]; other site 405534011162 putative active site [active] 405534011163 catalytic site [active] 405534011164 exopolyphosphatase; Region: exo_poly_only; TIGR03706 405534011165 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 405534011166 YkyB-like protein; Region: YkyB; pfam14177 405534011167 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 405534011168 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405534011169 I-site; other site 405534011170 active site 405534011171 metal binding site [ion binding]; metal-binding site 405534011172 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534011173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534011174 putative substrate translocation pore; other site 405534011175 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 405534011176 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405534011177 DNA binding residues [nucleotide binding] 405534011178 Probable transposase; Region: OrfB_IS605; pfam01385 405534011179 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405534011180 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405534011181 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 405534011182 Predicted transcriptional regulators [Transcription]; Region: COG1695 405534011183 Transcriptional regulator PadR-like family; Region: PadR; cl17335 405534011184 Cobalamin riboswitch 405534011185 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 405534011186 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 405534011187 THF binding site; other site 405534011188 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 405534011189 substrate binding site [chemical binding]; other site 405534011190 THF binding site; other site 405534011191 zinc-binding site [ion binding]; other site 405534011192 Competence protein J (ComJ); Region: ComJ; pfam11033 405534011193 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 405534011194 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 405534011195 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534011196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534011197 dimer interface [polypeptide binding]; other site 405534011198 phosphorylation site [posttranslational modification] 405534011199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534011200 ATP binding site [chemical binding]; other site 405534011201 Mg2+ binding site [ion binding]; other site 405534011202 G-X-G motif; other site 405534011203 aminotransferase A; Validated; Region: PRK07683 405534011204 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405534011205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534011206 homodimer interface [polypeptide binding]; other site 405534011207 catalytic residue [active] 405534011208 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405534011209 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405534011210 DNA binding site [nucleotide binding] 405534011211 domain linker motif; other site 405534011212 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 405534011213 putative dimerization interface [polypeptide binding]; other site 405534011214 putative ligand binding site [chemical binding]; other site 405534011215 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 405534011216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534011217 dimer interface [polypeptide binding]; other site 405534011218 conserved gate region; other site 405534011219 putative PBP binding loops; other site 405534011220 ABC-ATPase subunit interface; other site 405534011221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534011222 dimer interface [polypeptide binding]; other site 405534011223 conserved gate region; other site 405534011224 putative PBP binding loops; other site 405534011225 ABC-ATPase subunit interface; other site 405534011226 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 405534011227 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 405534011228 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 405534011229 homodimer interface [polypeptide binding]; other site 405534011230 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 405534011231 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 405534011232 active site 405534011233 homodimer interface [polypeptide binding]; other site 405534011234 catalytic site [active] 405534011235 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 405534011236 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 405534011237 Ca binding site [ion binding]; other site 405534011238 active site 405534011239 catalytic site [active] 405534011240 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 405534011241 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 405534011242 Walker A/P-loop; other site 405534011243 ATP binding site [chemical binding]; other site 405534011244 Q-loop/lid; other site 405534011245 ABC transporter signature motif; other site 405534011246 Walker B; other site 405534011247 D-loop; other site 405534011248 H-loop/switch region; other site 405534011249 TOBE domain; Region: TOBE_2; pfam08402 405534011250 hypothetical protein; Provisional; Region: PRK06720 405534011251 NAD(P) binding site [chemical binding]; other site 405534011252 RDD family; Region: RDD; pfam06271 405534011253 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 405534011254 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 405534011255 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 405534011256 Predicted ATPase [General function prediction only]; Region: COG3910 405534011257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534011258 Walker A/P-loop; other site 405534011259 ATP binding site [chemical binding]; other site 405534011260 Q-loop/lid; other site 405534011261 ABC transporter signature motif; other site 405534011262 Walker B; other site 405534011263 D-loop; other site 405534011264 H-loop/switch region; other site 405534011265 putative acyltransferase; Provisional; Region: PRK05790 405534011266 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 405534011267 dimer interface [polypeptide binding]; other site 405534011268 active site 405534011269 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 405534011270 nudix motif; other site 405534011271 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 405534011272 hypothetical protein; Validated; Region: PRK07668 405534011273 hypothetical protein; Validated; Region: PRK07668 405534011274 Predicted transcriptional regulators [Transcription]; Region: COG1695 405534011275 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405534011276 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 405534011277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405534011278 NAD(P) binding site [chemical binding]; other site 405534011279 active site 405534011280 YvrJ protein family; Region: YvrJ; pfam12841 405534011281 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 405534011282 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 405534011283 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 405534011284 Phosphotransferase enzyme family; Region: APH; pfam01636 405534011285 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 405534011286 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 405534011287 putative active site [active] 405534011288 putative NTP binding site [chemical binding]; other site 405534011289 putative nucleic acid binding site [nucleotide binding]; other site 405534011290 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 405534011291 active site 405534011292 Predicted amidohydrolase [General function prediction only]; Region: COG0388 405534011293 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 405534011294 putative active site [active] 405534011295 catalytic triad [active] 405534011296 putative dimer interface [polypeptide binding]; other site 405534011297 transaminase; Reviewed; Region: PRK08068 405534011298 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405534011299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534011300 homodimer interface [polypeptide binding]; other site 405534011301 catalytic residue [active] 405534011302 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 405534011303 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 405534011304 dimer interface [polypeptide binding]; other site 405534011305 active site 405534011306 catalytic residue [active] 405534011307 metal binding site [ion binding]; metal-binding site 405534011308 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 405534011309 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 405534011310 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 405534011311 intersubunit interface [polypeptide binding]; other site 405534011312 active site 405534011313 Zn2+ binding site [ion binding]; other site 405534011314 ARD/ARD' family; Region: ARD; pfam03079 405534011315 Cupin domain; Region: Cupin_2; pfam07883 405534011316 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 405534011317 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 405534011318 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405534011319 Beta-lactamase; Region: Beta-lactamase; pfam00144 405534011320 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405534011321 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405534011322 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405534011323 metal binding site [ion binding]; metal-binding site 405534011324 active site 405534011325 I-site; other site 405534011326 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 405534011327 dimer interface [polypeptide binding]; other site 405534011328 FMN binding site [chemical binding]; other site 405534011329 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 405534011330 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 405534011331 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 405534011332 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 405534011333 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 405534011334 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 405534011335 dimerization domain swap beta strand [polypeptide binding]; other site 405534011336 regulatory protein interface [polypeptide binding]; other site 405534011337 active site 405534011338 regulatory phosphorylation site [posttranslational modification]; other site 405534011339 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405534011340 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 405534011341 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405534011342 active site turn [active] 405534011343 phosphorylation site [posttranslational modification] 405534011344 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 405534011345 HPr interaction site; other site 405534011346 glycerol kinase (GK) interaction site [polypeptide binding]; other site 405534011347 active site 405534011348 phosphorylation site [posttranslational modification] 405534011349 transcriptional antiterminator BglG; Provisional; Region: PRK09772 405534011350 CAT RNA binding domain; Region: CAT_RBD; smart01061 405534011351 PRD domain; Region: PRD; pfam00874 405534011352 PRD domain; Region: PRD; pfam00874 405534011353 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405534011354 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534011355 active site 405534011356 motif I; other site 405534011357 motif II; other site 405534011358 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534011359 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 405534011360 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 405534011361 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 405534011362 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 405534011363 active site 405534011364 trimer interface [polypeptide binding]; other site 405534011365 allosteric site; other site 405534011366 active site lid [active] 405534011367 hexamer (dimer of trimers) interface [polypeptide binding]; other site 405534011368 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 405534011369 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 405534011370 active site 405534011371 dimer interface [polypeptide binding]; other site 405534011372 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 405534011373 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405534011374 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 405534011375 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 405534011376 Domain of unknown function (DUF309); Region: DUF309; pfam03745 405534011377 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534011378 Coenzyme A binding pocket [chemical binding]; other site 405534011379 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 405534011380 active site 405534011381 Predicted secreted protein [Function unknown]; Region: COG4086 405534011382 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 405534011383 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405534011384 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 405534011385 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 405534011386 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405534011387 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 405534011388 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 405534011389 stage V sporulation protein AD; Validated; Region: PRK08304 405534011390 stage V sporulation protein AD; Provisional; Region: PRK12404 405534011391 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 405534011392 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 405534011393 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 405534011394 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 405534011395 Na2 binding site [ion binding]; other site 405534011396 putative substrate binding site 1 [chemical binding]; other site 405534011397 Na binding site 1 [ion binding]; other site 405534011398 putative substrate binding site 2 [chemical binding]; other site 405534011399 sporulation sigma factor SigF; Validated; Region: PRK05572 405534011400 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405534011401 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 405534011402 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405534011403 DNA binding residues [nucleotide binding] 405534011404 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 405534011405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534011406 ATP binding site [chemical binding]; other site 405534011407 Mg2+ binding site [ion binding]; other site 405534011408 G-X-G motif; other site 405534011409 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 405534011410 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 405534011411 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405534011412 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 405534011413 Predicted transcriptional regulators [Transcription]; Region: COG1725 405534011414 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405534011415 DNA-binding site [nucleotide binding]; DNA binding site 405534011416 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405534011417 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405534011418 Walker A/P-loop; other site 405534011419 ATP binding site [chemical binding]; other site 405534011420 Q-loop/lid; other site 405534011421 ABC transporter signature motif; other site 405534011422 Walker B; other site 405534011423 D-loop; other site 405534011424 H-loop/switch region; other site 405534011425 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405534011426 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405534011427 MarR family; Region: MarR; pfam01047 405534011428 MarR family; Region: MarR_2; cl17246 405534011429 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 405534011430 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405534011431 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 405534011432 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 405534011433 oligomer interface [polypeptide binding]; other site 405534011434 metal binding site [ion binding]; metal-binding site 405534011435 metal binding site [ion binding]; metal-binding site 405534011436 putative Cl binding site [ion binding]; other site 405534011437 aspartate ring; other site 405534011438 basic sphincter; other site 405534011439 hydrophobic gate; other site 405534011440 periplasmic entrance; other site 405534011441 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 405534011442 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 405534011443 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 405534011444 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 405534011445 purine nucleoside phosphorylase; Provisional; Region: PRK08202 405534011446 phosphopentomutase; Provisional; Region: PRK05362 405534011447 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 405534011448 YtkA-like; Region: YtkA; pfam13115 405534011449 YtkA-like; Region: YtkA; pfam13115 405534011450 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 405534011451 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 405534011452 active site 405534011453 Int/Topo IB signature motif; other site 405534011454 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 405534011455 ferric uptake regulator; Provisional; Region: fur; PRK09462 405534011456 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 405534011457 metal binding site 2 [ion binding]; metal-binding site 405534011458 putative DNA binding helix; other site 405534011459 metal binding site 1 [ion binding]; metal-binding site 405534011460 dimer interface [polypeptide binding]; other site 405534011461 structural Zn2+ binding site [ion binding]; other site 405534011462 stage II sporulation protein M; Region: spo_II_M; TIGR02831 405534011463 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405534011464 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405534011465 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 405534011466 dimer interface [polypeptide binding]; other site 405534011467 ADP-ribose binding site [chemical binding]; other site 405534011468 active site 405534011469 nudix motif; other site 405534011470 metal binding site [ion binding]; metal-binding site 405534011471 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 405534011472 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405534011473 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405534011474 active site 405534011475 catalytic tetrad [active] 405534011476 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405534011477 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405534011478 active site 405534011479 catalytic tetrad [active] 405534011480 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 405534011481 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 405534011482 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 405534011483 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 405534011484 putative active site [active] 405534011485 putative metal binding site [ion binding]; other site 405534011486 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405534011487 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 405534011488 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405534011489 Predicted permease [General function prediction only]; Region: COG2056 405534011490 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 405534011491 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 405534011492 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405534011493 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405534011494 DNA binding site [nucleotide binding] 405534011495 domain linker motif; other site 405534011496 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 405534011497 dimerization interface [polypeptide binding]; other site 405534011498 ligand binding site [chemical binding]; other site 405534011499 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405534011500 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534011501 Coenzyme A binding pocket [chemical binding]; other site 405534011502 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 405534011503 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 405534011504 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 405534011505 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 405534011506 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 405534011507 catalytic motif [active] 405534011508 Zn binding site [ion binding]; other site 405534011509 RibD C-terminal domain; Region: RibD_C; cl17279 405534011510 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 405534011511 Lumazine binding domain; Region: Lum_binding; pfam00677 405534011512 Lumazine binding domain; Region: Lum_binding; pfam00677 405534011513 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 405534011514 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 405534011515 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 405534011516 dimerization interface [polypeptide binding]; other site 405534011517 active site 405534011518 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 405534011519 homopentamer interface [polypeptide binding]; other site 405534011520 active site 405534011521 biotin synthase; Validated; Region: PRK06256 405534011522 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405534011523 FeS/SAM binding site; other site 405534011524 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 405534011525 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 405534011526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534011527 S-adenosylmethionine binding site [chemical binding]; other site 405534011528 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 405534011529 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 405534011530 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 405534011531 substrate-cofactor binding pocket; other site 405534011532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534011533 catalytic residue [active] 405534011534 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 405534011535 AAA domain; Region: AAA_26; pfam13500 405534011536 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 405534011537 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405534011538 inhibitor-cofactor binding pocket; inhibition site 405534011539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534011540 catalytic residue [active] 405534011541 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 405534011542 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 405534011543 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 405534011544 active site 405534011545 metal binding site [ion binding]; metal-binding site 405534011546 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405534011547 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 405534011548 active site 405534011549 catalytic triad [active] 405534011550 oxyanion hole [active] 405534011551 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534011552 dimerization interface [polypeptide binding]; other site 405534011553 putative DNA binding site [nucleotide binding]; other site 405534011554 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405534011555 putative Zn2+ binding site [ion binding]; other site 405534011556 ornithine carbamoyltransferase; Provisional; Region: PRK00779 405534011557 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 405534011558 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 405534011559 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 405534011560 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405534011561 inhibitor-cofactor binding pocket; inhibition site 405534011562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534011563 catalytic residue [active] 405534011564 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 405534011565 nucleotide binding site [chemical binding]; other site 405534011566 N-acetyl-L-glutamate binding site [chemical binding]; other site 405534011567 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 405534011568 heterotetramer interface [polypeptide binding]; other site 405534011569 active site pocket [active] 405534011570 cleavage site 405534011571 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 405534011572 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 405534011573 YqzH-like protein; Region: YqzH; pfam14164 405534011574 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 405534011575 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405534011576 NAD(P) binding site [chemical binding]; other site 405534011577 active site 405534011578 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405534011579 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 405534011580 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 405534011581 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 405534011582 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 405534011583 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 405534011584 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 405534011585 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 405534011586 putative L-serine binding site [chemical binding]; other site 405534011587 ribonuclease Z; Region: RNase_Z; TIGR02651 405534011588 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 405534011589 DNA polymerase IV; Validated; Region: PRK01810 405534011590 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 405534011591 active site 405534011592 DNA binding site [nucleotide binding] 405534011593 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 405534011594 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 405534011595 peptidase T-like protein; Region: PepT-like; TIGR01883 405534011596 metal binding site [ion binding]; metal-binding site 405534011597 putative dimer interface [polypeptide binding]; other site 405534011598 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405534011599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405534011600 Protein of unknown function (DUF3894); Region: DUF3894; pfam13033 405534011601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 405534011602 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405534011603 Predicted membrane protein [Function unknown]; Region: COG4129 405534011604 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 405534011605 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 405534011606 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405534011607 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405534011608 Walker A/P-loop; other site 405534011609 ATP binding site [chemical binding]; other site 405534011610 Q-loop/lid; other site 405534011611 ABC transporter signature motif; other site 405534011612 Walker B; other site 405534011613 D-loop; other site 405534011614 H-loop/switch region; other site 405534011615 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 405534011616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534011617 dimer interface [polypeptide binding]; other site 405534011618 conserved gate region; other site 405534011619 putative PBP binding loops; other site 405534011620 ABC-ATPase subunit interface; other site 405534011621 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 405534011622 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405534011623 substrate binding pocket [chemical binding]; other site 405534011624 membrane-bound complex binding site; other site 405534011625 hinge residues; other site 405534011626 Disulphide isomerase; Region: Disulph_isomer; pfam06491 405534011627 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 405534011628 nudix motif; other site 405534011629 Predicted membrane protein [Function unknown]; Region: COG2323 405534011630 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 405534011631 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 405534011632 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405534011633 E3 interaction surface; other site 405534011634 lipoyl attachment site [posttranslational modification]; other site 405534011635 e3 binding domain; Region: E3_binding; pfam02817 405534011636 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 405534011637 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 405534011638 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 405534011639 alpha subunit interface [polypeptide binding]; other site 405534011640 TPP binding site [chemical binding]; other site 405534011641 heterodimer interface [polypeptide binding]; other site 405534011642 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405534011643 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 405534011644 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 405534011645 tetramer interface [polypeptide binding]; other site 405534011646 TPP-binding site [chemical binding]; other site 405534011647 heterodimer interface [polypeptide binding]; other site 405534011648 phosphorylation loop region [posttranslational modification] 405534011649 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 405534011650 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 405534011651 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405534011652 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405534011653 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405534011654 nucleotide binding site [chemical binding]; other site 405534011655 Acetokinase family; Region: Acetate_kinase; cl17229 405534011656 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 405534011657 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 405534011658 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 405534011659 NAD binding site [chemical binding]; other site 405534011660 Phe binding site; other site 405534011661 phosphate butyryltransferase; Validated; Region: PRK07742 405534011662 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405534011663 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 405534011664 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405534011665 putative active site [active] 405534011666 heme pocket [chemical binding]; other site 405534011667 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405534011668 putative active site [active] 405534011669 heme pocket [chemical binding]; other site 405534011670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534011671 Walker A motif; other site 405534011672 ATP binding site [chemical binding]; other site 405534011673 Walker B motif; other site 405534011674 arginine finger; other site 405534011675 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405534011676 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 405534011677 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 405534011678 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 405534011679 active site 405534011680 catalytic site [active] 405534011681 metal binding site [ion binding]; metal-binding site 405534011682 dimer interface [polypeptide binding]; other site 405534011683 YycC-like protein; Region: YycC; pfam14174 405534011684 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 405534011685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534011686 active site 405534011687 phosphorylation site [posttranslational modification] 405534011688 intermolecular recognition site; other site 405534011689 dimerization interface [polypeptide binding]; other site 405534011690 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 405534011691 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 405534011692 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 405534011693 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 405534011694 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 405534011695 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 405534011696 Walker A/P-loop; other site 405534011697 ATP binding site [chemical binding]; other site 405534011698 Q-loop/lid; other site 405534011699 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 405534011700 ABC transporter signature motif; other site 405534011701 Walker B; other site 405534011702 D-loop; other site 405534011703 H-loop/switch region; other site 405534011704 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 405534011705 arginine repressor; Provisional; Region: PRK04280 405534011706 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 405534011707 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 405534011708 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405534011709 RNA binding surface [nucleotide binding]; other site 405534011710 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 405534011711 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 405534011712 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 405534011713 TPP-binding site; other site 405534011714 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 405534011715 PYR/PP interface [polypeptide binding]; other site 405534011716 dimer interface [polypeptide binding]; other site 405534011717 TPP binding site [chemical binding]; other site 405534011718 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405534011719 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 405534011720 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 405534011721 substrate binding pocket [chemical binding]; other site 405534011722 chain length determination region; other site 405534011723 substrate-Mg2+ binding site; other site 405534011724 catalytic residues [active] 405534011725 aspartate-rich region 1; other site 405534011726 active site lid residues [active] 405534011727 aspartate-rich region 2; other site 405534011728 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 405534011729 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 405534011730 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 405534011731 generic binding surface II; other site 405534011732 generic binding surface I; other site 405534011733 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 405534011734 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 405534011735 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 405534011736 homodimer interface [polypeptide binding]; other site 405534011737 NADP binding site [chemical binding]; other site 405534011738 substrate binding site [chemical binding]; other site 405534011739 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 405534011740 putative RNA binding site [nucleotide binding]; other site 405534011741 Asp23 family; Region: Asp23; pfam03780 405534011742 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 405534011743 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405534011744 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 405534011745 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 405534011746 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 405534011747 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 405534011748 carboxyltransferase (CT) interaction site; other site 405534011749 biotinylation site [posttranslational modification]; other site 405534011750 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 405534011751 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 405534011752 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 405534011753 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 405534011754 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 405534011755 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 405534011756 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 405534011757 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 405534011758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534011759 Walker A motif; other site 405534011760 ATP binding site [chemical binding]; other site 405534011761 Walker B motif; other site 405534011762 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 405534011763 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405534011764 elongation factor P; Validated; Region: PRK00529 405534011765 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 405534011766 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 405534011767 RNA binding site [nucleotide binding]; other site 405534011768 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 405534011769 RNA binding site [nucleotide binding]; other site 405534011770 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 405534011771 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 405534011772 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 405534011773 active site 405534011774 Dehydroquinase class II; Region: DHquinase_II; pfam01220 405534011775 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 405534011776 trimer interface [polypeptide binding]; other site 405534011777 active site 405534011778 dimer interface [polypeptide binding]; other site 405534011779 Conserved membrane protein YqhR; Region: YqhR; pfam11085 405534011780 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 405534011781 manganese transport transcriptional regulator; Provisional; Region: PRK03902 405534011782 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 405534011783 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 405534011784 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 405534011785 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405534011786 FeS/SAM binding site; other site 405534011787 Predicted transcriptional regulators [Transcription]; Region: COG1695 405534011788 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405534011789 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 405534011790 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405534011791 active site residue [active] 405534011792 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405534011793 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405534011794 DNA binding site [nucleotide binding] 405534011795 domain linker motif; other site 405534011796 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 405534011797 putative dimerization interface [polypeptide binding]; other site 405534011798 putative ligand binding site [chemical binding]; other site 405534011799 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534011800 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534011801 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405534011802 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405534011803 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 405534011804 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 405534011805 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 405534011806 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 405534011807 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 405534011808 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405534011809 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405534011810 Walker A/P-loop; other site 405534011811 ATP binding site [chemical binding]; other site 405534011812 Q-loop/lid; other site 405534011813 ABC transporter signature motif; other site 405534011814 Walker B; other site 405534011815 D-loop; other site 405534011816 H-loop/switch region; other site 405534011817 Predicted transcriptional regulators [Transcription]; Region: COG1725 405534011818 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405534011819 DNA-binding site [nucleotide binding]; DNA binding site 405534011820 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 405534011821 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 405534011822 tetramer interface [polypeptide binding]; other site 405534011823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534011824 catalytic residue [active] 405534011825 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 405534011826 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 405534011827 tetramer interface [polypeptide binding]; other site 405534011828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534011829 catalytic residue [active] 405534011830 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 405534011831 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 405534011832 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 405534011833 DEAD-like helicases superfamily; Region: DEXDc; smart00487 405534011834 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405534011835 ATP binding site [chemical binding]; other site 405534011836 putative Mg++ binding site [ion binding]; other site 405534011837 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405534011838 nucleotide binding region [chemical binding]; other site 405534011839 ATP-binding site [chemical binding]; other site 405534011840 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 405534011841 YqzE-like protein; Region: YqzE; pfam14038 405534011842 shikimate kinase; Reviewed; Region: aroK; PRK00131 405534011843 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 405534011844 ADP binding site [chemical binding]; other site 405534011845 magnesium binding site [ion binding]; other site 405534011846 putative shikimate binding site; other site 405534011847 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 405534011848 ComG operon protein 7; Region: ComGG; pfam14173 405534011849 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 405534011850 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 405534011851 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 405534011852 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 405534011853 Type II/IV secretion system protein; Region: T2SE; pfam00437 405534011854 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 405534011855 Walker A motif; other site 405534011856 ATP binding site [chemical binding]; other site 405534011857 Walker B motif; other site 405534011858 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534011859 putative DNA binding site [nucleotide binding]; other site 405534011860 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 405534011861 putative Zn2+ binding site [ion binding]; other site 405534011862 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 405534011863 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 405534011864 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405534011865 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 405534011866 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 405534011867 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405534011868 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 405534011869 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 405534011870 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 405534011871 active site 405534011872 homodimer interface [polypeptide binding]; other site 405534011873 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 405534011874 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 405534011875 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 405534011876 substrate binding pocket [chemical binding]; other site 405534011877 dimer interface [polypeptide binding]; other site 405534011878 inhibitor binding site; inhibition site 405534011879 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 405534011880 B12 binding site [chemical binding]; other site 405534011881 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 405534011882 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 405534011883 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 405534011884 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 405534011885 FAD binding site [chemical binding]; other site 405534011886 cystathionine gamma-synthase; Reviewed; Region: PRK08247 405534011887 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 405534011888 homodimer interface [polypeptide binding]; other site 405534011889 substrate-cofactor binding pocket; other site 405534011890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534011891 catalytic residue [active] 405534011892 cystathionine beta-lyase; Provisional; Region: PRK08064 405534011893 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 405534011894 homodimer interface [polypeptide binding]; other site 405534011895 substrate-cofactor binding pocket; other site 405534011896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534011897 catalytic residue [active] 405534011898 Isochorismatase family; Region: Isochorismatase; pfam00857 405534011899 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 405534011900 catalytic triad [active] 405534011901 conserved cis-peptide bond; other site 405534011902 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534011903 dimerization interface [polypeptide binding]; other site 405534011904 putative DNA binding site [nucleotide binding]; other site 405534011905 putative Zn2+ binding site [ion binding]; other site 405534011906 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 405534011907 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 405534011908 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 405534011909 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 405534011910 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405534011911 nucleotide binding site [chemical binding]; other site 405534011912 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 405534011913 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 405534011914 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 405534011915 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 405534011916 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 405534011917 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 405534011918 active site 405534011919 Substrate binding site; other site 405534011920 Mg++ binding site; other site 405534011921 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 405534011922 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 405534011923 active site 405534011924 metal binding site [ion binding]; metal-binding site 405534011925 substrate binding site [chemical binding]; other site 405534011926 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 405534011927 PhoU domain; Region: PhoU; pfam01895 405534011928 PhoU domain; Region: PhoU; pfam01895 405534011929 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 405534011930 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 405534011931 Walker A/P-loop; other site 405534011932 ATP binding site [chemical binding]; other site 405534011933 Q-loop/lid; other site 405534011934 ABC transporter signature motif; other site 405534011935 Walker B; other site 405534011936 D-loop; other site 405534011937 H-loop/switch region; other site 405534011938 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 405534011939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534011940 dimer interface [polypeptide binding]; other site 405534011941 conserved gate region; other site 405534011942 putative PBP binding loops; other site 405534011943 ABC-ATPase subunit interface; other site 405534011944 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 405534011945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534011946 dimer interface [polypeptide binding]; other site 405534011947 conserved gate region; other site 405534011948 putative PBP binding loops; other site 405534011949 ABC-ATPase subunit interface; other site 405534011950 PBP superfamily domain; Region: PBP_like_2; cl17296 405534011951 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405534011952 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405534011953 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405534011954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534011955 putative substrate translocation pore; other site 405534011956 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534011957 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 405534011958 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 405534011959 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 405534011960 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 405534011961 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 405534011962 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 405534011963 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 405534011964 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 405534011965 metal binding site 2 [ion binding]; metal-binding site 405534011966 putative DNA binding helix; other site 405534011967 metal binding site 1 [ion binding]; metal-binding site 405534011968 dimer interface [polypeptide binding]; other site 405534011969 structural Zn2+ binding site [ion binding]; other site 405534011970 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 405534011971 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405534011972 ABC-ATPase subunit interface; other site 405534011973 dimer interface [polypeptide binding]; other site 405534011974 putative PBP binding regions; other site 405534011975 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 405534011976 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 405534011977 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405534011978 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405534011979 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405534011980 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 405534011981 endonuclease IV; Provisional; Region: PRK01060 405534011982 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 405534011983 AP (apurinic/apyrimidinic) site pocket; other site 405534011984 DNA interaction; other site 405534011985 Metal-binding active site; metal-binding site 405534011986 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 405534011987 DEAD-like helicases superfamily; Region: DEXDc; smart00487 405534011988 ATP binding site [chemical binding]; other site 405534011989 Mg++ binding site [ion binding]; other site 405534011990 motif III; other site 405534011991 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405534011992 nucleotide binding region [chemical binding]; other site 405534011993 ATP-binding site [chemical binding]; other site 405534011994 YqfQ-like protein; Region: YqfQ; pfam14181 405534011995 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 405534011996 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 405534011997 Uncharacterized conserved protein [Function unknown]; Region: COG0327 405534011998 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 405534011999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 405534012000 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 405534012001 Uncharacterized conserved protein [Function unknown]; Region: COG0327 405534012002 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 405534012003 Family of unknown function (DUF633); Region: DUF633; pfam04816 405534012004 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 405534012005 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 405534012006 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 405534012007 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 405534012008 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 405534012009 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405534012010 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 405534012011 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405534012012 DNA binding residues [nucleotide binding] 405534012013 DNA primase; Validated; Region: dnaG; PRK05667 405534012014 CHC2 zinc finger; Region: zf-CHC2; pfam01807 405534012015 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 405534012016 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 405534012017 active site 405534012018 metal binding site [ion binding]; metal-binding site 405534012019 interdomain interaction site; other site 405534012020 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 405534012021 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 405534012022 PEP synthetase regulatory protein; Provisional; Region: PRK05339 405534012023 HTH domain; Region: HTH_11; pfam08279 405534012024 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 405534012025 FOG: CBS domain [General function prediction only]; Region: COG0517 405534012026 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 405534012027 Recombination protein O N terminal; Region: RecO_N; pfam11967 405534012028 Recombination protein O C terminal; Region: RecO_C; pfam02565 405534012029 YqzL-like protein; Region: YqzL; pfam14006 405534012030 GTPase Era; Reviewed; Region: era; PRK00089 405534012031 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 405534012032 G1 box; other site 405534012033 GTP/Mg2+ binding site [chemical binding]; other site 405534012034 Switch I region; other site 405534012035 G2 box; other site 405534012036 Switch II region; other site 405534012037 G3 box; other site 405534012038 G4 box; other site 405534012039 G5 box; other site 405534012040 KH domain; Region: KH_2; pfam07650 405534012041 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 405534012042 active site 405534012043 catalytic motif [active] 405534012044 Zn binding site [ion binding]; other site 405534012045 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 405534012046 metal-binding heat shock protein; Provisional; Region: PRK00016 405534012047 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 405534012048 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 405534012049 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405534012050 Zn2+ binding site [ion binding]; other site 405534012051 Mg2+ binding site [ion binding]; other site 405534012052 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 405534012053 PhoH-like protein; Region: PhoH; pfam02562 405534012054 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 405534012055 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 405534012056 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 405534012057 Yqey-like protein; Region: YqeY; pfam09424 405534012058 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 405534012059 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 405534012060 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 405534012061 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405534012062 FeS/SAM binding site; other site 405534012063 TRAM domain; Region: TRAM; cl01282 405534012064 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 405534012065 RNA methyltransferase, RsmE family; Region: TIGR00046 405534012066 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 405534012067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534012068 S-adenosylmethionine binding site [chemical binding]; other site 405534012069 chaperone protein DnaJ; Provisional; Region: PRK14280 405534012070 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 405534012071 HSP70 interaction site [polypeptide binding]; other site 405534012072 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 405534012073 substrate binding site [polypeptide binding]; other site 405534012074 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 405534012075 Zn binding sites [ion binding]; other site 405534012076 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 405534012077 dimer interface [polypeptide binding]; other site 405534012078 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 405534012079 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 405534012080 nucleotide binding site [chemical binding]; other site 405534012081 NEF interaction site [polypeptide binding]; other site 405534012082 SBD interface [polypeptide binding]; other site 405534012083 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 405534012084 GrpE; Region: GrpE; pfam01025 405534012085 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 405534012086 dimer interface [polypeptide binding]; other site 405534012087 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 405534012088 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 405534012089 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 405534012090 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 405534012091 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405534012092 FeS/SAM binding site; other site 405534012093 HemN C-terminal domain; Region: HemN_C; pfam06969 405534012094 Predicted transcriptional regulators [Transcription]; Region: COG1733 405534012095 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 405534012096 GTP-binding protein LepA; Provisional; Region: PRK05433 405534012097 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 405534012098 G1 box; other site 405534012099 putative GEF interaction site [polypeptide binding]; other site 405534012100 GTP/Mg2+ binding site [chemical binding]; other site 405534012101 Switch I region; other site 405534012102 G2 box; other site 405534012103 G3 box; other site 405534012104 Switch II region; other site 405534012105 G4 box; other site 405534012106 G5 box; other site 405534012107 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 405534012108 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 405534012109 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 405534012110 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 405534012111 germination protease; Provisional; Region: PRK02858 405534012112 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 405534012113 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 405534012114 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 405534012115 YqzM-like protein; Region: YqzM; pfam14141 405534012116 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 405534012117 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 405534012118 Competence protein; Region: Competence; pfam03772 405534012119 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405534012120 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 405534012121 catalytic motif [active] 405534012122 Zn binding site [ion binding]; other site 405534012123 SLBB domain; Region: SLBB; pfam10531 405534012124 comEA protein; Region: comE; TIGR01259 405534012125 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 405534012126 late competence protein ComER; Validated; Region: PRK07680 405534012127 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 405534012128 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 405534012129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534012130 S-adenosylmethionine binding site [chemical binding]; other site 405534012131 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 405534012132 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405534012133 Zn2+ binding site [ion binding]; other site 405534012134 Mg2+ binding site [ion binding]; other site 405534012135 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 405534012136 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 405534012137 active site 405534012138 (T/H)XGH motif; other site 405534012139 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 405534012140 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 405534012141 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 405534012142 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 405534012143 shikimate binding site; other site 405534012144 NAD(P) binding site [chemical binding]; other site 405534012145 GTPase YqeH; Provisional; Region: PRK13796 405534012146 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 405534012147 GTP/Mg2+ binding site [chemical binding]; other site 405534012148 G4 box; other site 405534012149 G5 box; other site 405534012150 G1 box; other site 405534012151 Switch I region; other site 405534012152 G2 box; other site 405534012153 G3 box; other site 405534012154 Switch II region; other site 405534012155 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 405534012156 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534012157 active site 405534012158 motif I; other site 405534012159 motif II; other site 405534012160 Sporulation inhibitor A; Region: Sda; pfam08970 405534012161 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 405534012162 sporulation sigma factor SigK; Reviewed; Region: PRK05803 405534012163 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405534012164 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405534012165 DNA binding residues [nucleotide binding] 405534012166 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 405534012167 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 405534012168 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 405534012169 synthetase active site [active] 405534012170 NTP binding site [chemical binding]; other site 405534012171 metal binding site [ion binding]; metal-binding site 405534012172 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 405534012173 dimer interface [polypeptide binding]; other site 405534012174 Alkaline phosphatase homologues; Region: alkPPc; smart00098 405534012175 active site 405534012176 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534012177 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405534012178 Coenzyme A binding pocket [chemical binding]; other site 405534012179 PGAP1-like protein; Region: PGAP1; pfam07819 405534012180 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405534012181 DoxX; Region: DoxX; cl17842 405534012182 CHAT domain; Region: CHAT; cl17868 405534012183 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 405534012184 catalytic core [active] 405534012185 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 405534012186 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 405534012187 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 405534012188 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 405534012189 putative active site [active] 405534012190 catalytic triad [active] 405534012191 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 405534012192 putative integrin binding motif; other site 405534012193 PA/protease domain interface [polypeptide binding]; other site 405534012194 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 405534012195 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 405534012196 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 405534012197 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 405534012198 cofactor binding site; other site 405534012199 metal binding site [ion binding]; metal-binding site 405534012200 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 405534012201 aromatic arch; other site 405534012202 DCoH dimer interaction site [polypeptide binding]; other site 405534012203 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 405534012204 DCoH tetramer interaction site [polypeptide binding]; other site 405534012205 substrate binding site [chemical binding]; other site 405534012206 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 405534012207 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 405534012208 putative metal binding site [ion binding]; other site 405534012209 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405534012210 active site 405534012211 metal binding site [ion binding]; metal-binding site 405534012212 Predicted membrane protein [Function unknown]; Region: COG2259 405534012213 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 405534012214 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534012215 non-specific DNA binding site [nucleotide binding]; other site 405534012216 salt bridge; other site 405534012217 sequence-specific DNA binding site [nucleotide binding]; other site 405534012218 Cupin domain; Region: Cupin_2; pfam07883 405534012219 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 405534012220 active site 2 [active] 405534012221 active site 1 [active] 405534012222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534012223 Coenzyme A binding pocket [chemical binding]; other site 405534012224 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405534012225 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405534012226 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 405534012227 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 405534012228 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405534012229 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405534012230 Walker A/P-loop; other site 405534012231 ATP binding site [chemical binding]; other site 405534012232 Q-loop/lid; other site 405534012233 ABC transporter signature motif; other site 405534012234 Walker B; other site 405534012235 D-loop; other site 405534012236 H-loop/switch region; other site 405534012237 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405534012238 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405534012239 ABC-ATPase subunit interface; other site 405534012240 dimer interface [polypeptide binding]; other site 405534012241 putative PBP binding regions; other site 405534012242 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405534012243 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 405534012244 intersubunit interface [polypeptide binding]; other site 405534012245 YrhC-like protein; Region: YrhC; pfam14143 405534012246 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 405534012247 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 405534012248 putative catalytic cysteine [active] 405534012249 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 405534012250 putative active site [active] 405534012251 metal binding site [ion binding]; metal-binding site 405534012252 cystathionine beta-lyase; Provisional; Region: PRK07671 405534012253 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 405534012254 homodimer interface [polypeptide binding]; other site 405534012255 substrate-cofactor binding pocket; other site 405534012256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534012257 catalytic residue [active] 405534012258 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 405534012259 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 405534012260 dimer interface [polypeptide binding]; other site 405534012261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534012262 catalytic residue [active] 405534012263 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 405534012264 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 405534012265 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405534012266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534012267 S-adenosylmethionine binding site [chemical binding]; other site 405534012268 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 405534012269 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 405534012270 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405534012271 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405534012272 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405534012273 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 405534012274 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 405534012275 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 405534012276 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 405534012277 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 405534012278 ATP-binding site [chemical binding]; other site 405534012279 Sugar specificity; other site 405534012280 Pyrimidine base specificity; other site 405534012281 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 405534012282 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 405534012283 Peptidase family U32; Region: Peptidase_U32; pfam01136 405534012284 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 405534012285 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 405534012286 Peptidase family U32; Region: Peptidase_U32; pfam01136 405534012287 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 405534012288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534012289 S-adenosylmethionine binding site [chemical binding]; other site 405534012290 YceG-like family; Region: YceG; pfam02618 405534012291 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 405534012292 dimerization interface [polypeptide binding]; other site 405534012293 hypothetical protein; Provisional; Region: PRK13678 405534012294 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 405534012295 hypothetical protein; Provisional; Region: PRK05473 405534012296 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 405534012297 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 405534012298 motif 1; other site 405534012299 active site 405534012300 motif 2; other site 405534012301 motif 3; other site 405534012302 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 405534012303 DHHA1 domain; Region: DHHA1; pfam02272 405534012304 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 405534012305 Domain of unknown function DUF20; Region: UPF0118; pfam01594 405534012306 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 405534012307 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 405534012308 AAA domain; Region: AAA_30; pfam13604 405534012309 Family description; Region: UvrD_C_2; pfam13538 405534012310 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405534012311 TPR motif; other site 405534012312 TPR repeat; Region: TPR_11; pfam13414 405534012313 binding surface 405534012314 TPR repeat; Region: TPR_11; pfam13414 405534012315 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405534012316 binding surface 405534012317 TPR motif; other site 405534012318 TPR repeat; Region: TPR_11; pfam13414 405534012319 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 405534012320 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 405534012321 Ligand Binding Site [chemical binding]; other site 405534012322 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 405534012323 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 405534012324 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405534012325 catalytic residue [active] 405534012326 Predicted transcriptional regulator [Transcription]; Region: COG1959 405534012327 Transcriptional regulator; Region: Rrf2; pfam02082 405534012328 recombination factor protein RarA; Reviewed; Region: PRK13342 405534012329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534012330 Walker A motif; other site 405534012331 ATP binding site [chemical binding]; other site 405534012332 Walker B motif; other site 405534012333 arginine finger; other site 405534012334 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 405534012335 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 405534012336 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 405534012337 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 405534012338 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 405534012339 putative ATP binding site [chemical binding]; other site 405534012340 putative substrate interface [chemical binding]; other site 405534012341 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 405534012342 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 405534012343 dimer interface [polypeptide binding]; other site 405534012344 anticodon binding site; other site 405534012345 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 405534012346 homodimer interface [polypeptide binding]; other site 405534012347 motif 1; other site 405534012348 active site 405534012349 motif 2; other site 405534012350 GAD domain; Region: GAD; pfam02938 405534012351 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 405534012352 motif 3; other site 405534012353 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 405534012354 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 405534012355 dimer interface [polypeptide binding]; other site 405534012356 motif 1; other site 405534012357 active site 405534012358 motif 2; other site 405534012359 motif 3; other site 405534012360 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 405534012361 anticodon binding site; other site 405534012362 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405534012363 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 405534012364 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 405534012365 putative active site [active] 405534012366 dimerization interface [polypeptide binding]; other site 405534012367 putative tRNAtyr binding site [nucleotide binding]; other site 405534012368 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 405534012369 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405534012370 Zn2+ binding site [ion binding]; other site 405534012371 Mg2+ binding site [ion binding]; other site 405534012372 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 405534012373 synthetase active site [active] 405534012374 NTP binding site [chemical binding]; other site 405534012375 metal binding site [ion binding]; metal-binding site 405534012376 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 405534012377 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 405534012378 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405534012379 active site 405534012380 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 405534012381 DHH family; Region: DHH; pfam01368 405534012382 DHHA1 domain; Region: DHHA1; pfam02272 405534012383 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 405534012384 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 405534012385 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 405534012386 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 405534012387 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 405534012388 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 405534012389 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 405534012390 Protein export membrane protein; Region: SecD_SecF; pfam02355 405534012391 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 405534012392 stage V sporulation protein B; Region: spore_V_B; TIGR02900 405534012393 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405534012394 Predicted membrane protein [Function unknown]; Region: COG2323 405534012395 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 405534012396 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 405534012397 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 405534012398 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 405534012399 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 405534012400 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 405534012401 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 405534012402 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 405534012403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534012404 Walker A motif; other site 405534012405 ATP binding site [chemical binding]; other site 405534012406 Walker B motif; other site 405534012407 arginine finger; other site 405534012408 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 405534012409 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 405534012410 RuvA N terminal domain; Region: RuvA_N; pfam01330 405534012411 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 405534012412 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 405534012413 BofC C-terminal domain; Region: BofC_C; pfam08955 405534012414 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 405534012415 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405534012416 quinolinate synthetase; Provisional; Region: PRK09375 405534012417 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 405534012418 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 405534012419 dimerization interface [polypeptide binding]; other site 405534012420 active site 405534012421 L-aspartate oxidase; Provisional; Region: PRK08071 405534012422 L-aspartate oxidase; Provisional; Region: PRK06175 405534012423 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 405534012424 cysteine desulfurase; Provisional; Region: PRK02948 405534012425 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 405534012426 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405534012427 catalytic residue [active] 405534012428 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 405534012429 HTH domain; Region: HTH_11; pfam08279 405534012430 3H domain; Region: 3H; pfam02829 405534012431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 405534012432 MOSC domain; Region: MOSC; pfam03473 405534012433 3-alpha domain; Region: 3-alpha; pfam03475 405534012434 prephenate dehydratase; Provisional; Region: PRK11898 405534012435 Prephenate dehydratase; Region: PDT; pfam00800 405534012436 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 405534012437 putative L-Phe binding site [chemical binding]; other site 405534012438 FtsX-like permease family; Region: FtsX; pfam02687 405534012439 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405534012440 FtsX-like permease family; Region: FtsX; pfam02687 405534012441 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405534012442 FtsX-like permease family; Region: FtsX; pfam02687 405534012443 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405534012444 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405534012445 Walker A/P-loop; other site 405534012446 ATP binding site [chemical binding]; other site 405534012447 Q-loop/lid; other site 405534012448 ABC transporter signature motif; other site 405534012449 Walker B; other site 405534012450 D-loop; other site 405534012451 H-loop/switch region; other site 405534012452 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534012453 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 405534012454 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534012455 ATP binding site [chemical binding]; other site 405534012456 Mg2+ binding site [ion binding]; other site 405534012457 G-X-G motif; other site 405534012458 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534012459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534012460 active site 405534012461 phosphorylation site [posttranslational modification] 405534012462 intermolecular recognition site; other site 405534012463 dimerization interface [polypeptide binding]; other site 405534012464 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534012465 DNA binding site [nucleotide binding] 405534012466 GTPase CgtA; Reviewed; Region: obgE; PRK12297 405534012467 GTP1/OBG; Region: GTP1_OBG; pfam01018 405534012468 Obg GTPase; Region: Obg; cd01898 405534012469 G1 box; other site 405534012470 GTP/Mg2+ binding site [chemical binding]; other site 405534012471 Switch I region; other site 405534012472 G2 box; other site 405534012473 G3 box; other site 405534012474 Switch II region; other site 405534012475 G4 box; other site 405534012476 G5 box; other site 405534012477 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 405534012478 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 405534012479 hypothetical protein; Provisional; Region: PRK14553 405534012480 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 405534012481 Ribosomal protein L21 leader 405534012482 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 405534012483 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 405534012484 homodimer interface [polypeptide binding]; other site 405534012485 oligonucleotide binding site [chemical binding]; other site 405534012486 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 405534012487 Peptidase family M50; Region: Peptidase_M50; pfam02163 405534012488 active site 405534012489 putative substrate binding region [chemical binding]; other site 405534012490 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405534012491 Peptidase family M23; Region: Peptidase_M23; pfam01551 405534012492 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 405534012493 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 405534012494 Switch I; other site 405534012495 Switch II; other site 405534012496 septum formation inhibitor; Reviewed; Region: minC; PRK00513 405534012497 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 405534012498 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 405534012499 rod shape-determining protein MreC; Provisional; Region: PRK13922 405534012500 rod shape-determining protein MreC; Region: MreC; pfam04085 405534012501 rod shape-determining protein MreB; Provisional; Region: PRK13927 405534012502 MreB and similar proteins; Region: MreB_like; cd10225 405534012503 nucleotide binding site [chemical binding]; other site 405534012504 Mg binding site [ion binding]; other site 405534012505 putative protofilament interaction site [polypeptide binding]; other site 405534012506 RodZ interaction site [polypeptide binding]; other site 405534012507 hypothetical protein; Reviewed; Region: PRK00024 405534012508 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 405534012509 MPN+ (JAMM) motif; other site 405534012510 Zinc-binding site [ion binding]; other site 405534012511 Maf-like protein; Region: Maf; pfam02545 405534012512 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 405534012513 active site 405534012514 dimer interface [polypeptide binding]; other site 405534012515 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 405534012516 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405534012517 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405534012518 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 405534012519 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 405534012520 active site 405534012521 HIGH motif; other site 405534012522 nucleotide binding site [chemical binding]; other site 405534012523 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 405534012524 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 405534012525 active site 405534012526 KMSKS motif; other site 405534012527 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 405534012528 tRNA binding surface [nucleotide binding]; other site 405534012529 anticodon binding site; other site 405534012530 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 405534012531 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 405534012532 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 405534012533 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405534012534 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 405534012535 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405534012536 inhibitor-cofactor binding pocket; inhibition site 405534012537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534012538 catalytic residue [active] 405534012539 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 405534012540 dimer interface [polypeptide binding]; other site 405534012541 active site 405534012542 Schiff base residues; other site 405534012543 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 405534012544 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 405534012545 active site 405534012546 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 405534012547 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 405534012548 domain interfaces; other site 405534012549 active site 405534012550 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 405534012551 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 405534012552 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 405534012553 tRNA; other site 405534012554 putative tRNA binding site [nucleotide binding]; other site 405534012555 putative NADP binding site [chemical binding]; other site 405534012556 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 405534012557 Transcriptional regulators [Transcription]; Region: MarR; COG1846 405534012558 MarR family; Region: MarR; pfam01047 405534012559 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 405534012560 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 405534012561 G1 box; other site 405534012562 GTP/Mg2+ binding site [chemical binding]; other site 405534012563 Switch I region; other site 405534012564 G2 box; other site 405534012565 G3 box; other site 405534012566 Switch II region; other site 405534012567 G4 box; other site 405534012568 G5 box; other site 405534012569 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 405534012570 Found in ATP-dependent protease La (LON); Region: LON; smart00464 405534012571 Found in ATP-dependent protease La (LON); Region: LON; smart00464 405534012572 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534012573 Walker A motif; other site 405534012574 ATP binding site [chemical binding]; other site 405534012575 Walker B motif; other site 405534012576 arginine finger; other site 405534012577 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 405534012578 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 405534012579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534012580 Walker A motif; other site 405534012581 ATP binding site [chemical binding]; other site 405534012582 Walker B motif; other site 405534012583 arginine finger; other site 405534012584 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 405534012585 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 405534012586 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 405534012587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534012588 Walker A motif; other site 405534012589 ATP binding site [chemical binding]; other site 405534012590 Walker B motif; other site 405534012591 arginine finger; other site 405534012592 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 405534012593 trigger factor; Provisional; Region: tig; PRK01490 405534012594 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 405534012595 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 405534012596 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 405534012597 pentamer interface [polypeptide binding]; other site 405534012598 dodecaamer interface [polypeptide binding]; other site 405534012599 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 405534012600 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 405534012601 active site 405534012602 metal binding site [ion binding]; metal-binding site 405534012603 homotetramer interface [polypeptide binding]; other site 405534012604 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 405534012605 active site 405534012606 dimerization interface [polypeptide binding]; other site 405534012607 ribonuclease PH; Reviewed; Region: rph; PRK00173 405534012608 Ribonuclease PH; Region: RNase_PH_bact; cd11362 405534012609 hexamer interface [polypeptide binding]; other site 405534012610 active site 405534012611 Sporulation and spore germination; Region: Germane; pfam10646 405534012612 Spore germination protein [General function prediction only]; Region: COG5401 405534012613 Sporulation and spore germination; Region: Germane; pfam10646 405534012614 glutamate racemase; Provisional; Region: PRK00865 405534012615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534012616 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534012617 putative substrate translocation pore; other site 405534012618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534012619 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 405534012620 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 405534012621 potential catalytic triad [active] 405534012622 conserved cys residue [active] 405534012623 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534012624 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534012625 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 405534012626 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 405534012627 potential catalytic triad [active] 405534012628 conserved cys residue [active] 405534012629 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405534012630 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405534012631 DNA binding residues [nucleotide binding] 405534012632 dimerization interface [polypeptide binding]; other site 405534012633 putative uracil/xanthine transporter; Provisional; Region: PRK11412 405534012634 putative deaminase; Validated; Region: PRK06846 405534012635 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 405534012636 active site 405534012637 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 405534012638 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 405534012639 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534012640 non-specific DNA binding site [nucleotide binding]; other site 405534012641 salt bridge; other site 405534012642 sequence-specific DNA binding site [nucleotide binding]; other site 405534012643 Cupin domain; Region: Cupin_2; pfam07883 405534012644 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 405534012645 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 405534012646 amphipathic channel; other site 405534012647 Asn-Pro-Ala signature motifs; other site 405534012648 Predicted transcriptional regulator [Transcription]; Region: COG1959 405534012649 Transcriptional regulator; Region: Rrf2; pfam02082 405534012650 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 405534012651 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 405534012652 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534012653 Walker A/P-loop; other site 405534012654 ATP binding site [chemical binding]; other site 405534012655 Q-loop/lid; other site 405534012656 ABC transporter signature motif; other site 405534012657 Walker B; other site 405534012658 D-loop; other site 405534012659 H-loop/switch region; other site 405534012660 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 405534012661 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534012662 active site 405534012663 motif I; other site 405534012664 motif II; other site 405534012665 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 405534012666 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 405534012667 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 405534012668 ligand binding site [chemical binding]; other site 405534012669 flagellar motor protein MotA; Validated; Region: PRK08124 405534012670 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 405534012671 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 405534012672 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 405534012673 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 405534012674 active site 405534012675 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 405534012676 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 405534012677 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 405534012678 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 405534012679 L-aspartate oxidase; Provisional; Region: PRK06175 405534012680 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 405534012681 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 405534012682 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 405534012683 putative Iron-sulfur protein interface [polypeptide binding]; other site 405534012684 proximal heme binding site [chemical binding]; other site 405534012685 distal heme binding site [chemical binding]; other site 405534012686 putative dimer interface [polypeptide binding]; other site 405534012687 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 405534012688 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 405534012689 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 405534012690 GIY-YIG motif/motif A; other site 405534012691 active site 405534012692 catalytic site [active] 405534012693 putative DNA binding site [nucleotide binding]; other site 405534012694 metal binding site [ion binding]; metal-binding site 405534012695 UvrB/uvrC motif; Region: UVR; pfam02151 405534012696 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 405534012697 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405534012698 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 405534012699 catalytic residues [active] 405534012700 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 405534012701 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 405534012702 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 405534012703 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 405534012704 Ligand binding site [chemical binding]; other site 405534012705 Electron transfer flavoprotein domain; Region: ETF; pfam01012 405534012706 enoyl-CoA hydratase; Provisional; Region: PRK07658 405534012707 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405534012708 substrate binding site [chemical binding]; other site 405534012709 oxyanion hole (OAH) forming residues; other site 405534012710 trimer interface [polypeptide binding]; other site 405534012711 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 405534012712 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534012713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534012714 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 405534012715 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 405534012716 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 405534012717 acyl-activating enzyme (AAE) consensus motif; other site 405534012718 putative AMP binding site [chemical binding]; other site 405534012719 putative active site [active] 405534012720 putative CoA binding site [chemical binding]; other site 405534012721 DinB family; Region: DinB; pfam05163 405534012722 DinB superfamily; Region: DinB_2; pfam12867 405534012723 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405534012724 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 405534012725 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 405534012726 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405534012727 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 405534012728 Walker A/P-loop; other site 405534012729 ATP binding site [chemical binding]; other site 405534012730 Q-loop/lid; other site 405534012731 ABC transporter signature motif; other site 405534012732 Walker B; other site 405534012733 D-loop; other site 405534012734 H-loop/switch region; other site 405534012735 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534012736 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534012737 dimer interface [polypeptide binding]; other site 405534012738 phosphorylation site [posttranslational modification] 405534012739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534012740 ATP binding site [chemical binding]; other site 405534012741 Mg2+ binding site [ion binding]; other site 405534012742 G-X-G motif; other site 405534012743 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534012744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534012745 active site 405534012746 phosphorylation site [posttranslational modification] 405534012747 intermolecular recognition site; other site 405534012748 dimerization interface [polypeptide binding]; other site 405534012749 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534012750 DNA binding site [nucleotide binding] 405534012751 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 405534012752 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 405534012753 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 405534012754 putative RNA binding site [nucleotide binding]; other site 405534012755 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 405534012756 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 405534012757 TrkA-N domain; Region: TrkA_N; pfam02254 405534012758 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 405534012759 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 405534012760 active site 405534012761 catalytic site [active] 405534012762 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405534012763 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405534012764 Walker A/P-loop; other site 405534012765 ATP binding site [chemical binding]; other site 405534012766 Q-loop/lid; other site 405534012767 ABC transporter signature motif; other site 405534012768 Walker B; other site 405534012769 D-loop; other site 405534012770 H-loop/switch region; other site 405534012771 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405534012772 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405534012773 ABC-ATPase subunit interface; other site 405534012774 dimer interface [polypeptide binding]; other site 405534012775 putative PBP binding regions; other site 405534012776 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 405534012777 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 405534012778 intersubunit interface [polypeptide binding]; other site 405534012779 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405534012780 heme-binding site [chemical binding]; other site 405534012781 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405534012782 heme-binding site [chemical binding]; other site 405534012783 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405534012784 heme-binding site [chemical binding]; other site 405534012785 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405534012786 heme-binding site [chemical binding]; other site 405534012787 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405534012788 heme-binding site [chemical binding]; other site 405534012789 heme uptake protein IsdC; Region: IsdC; TIGR03656 405534012790 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405534012791 heme-binding site [chemical binding]; other site 405534012792 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 405534012793 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 405534012794 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 405534012795 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405534012796 RNA binding surface [nucleotide binding]; other site 405534012797 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 405534012798 probable active site [active] 405534012799 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 405534012800 MutS domain III; Region: MutS_III; pfam05192 405534012801 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 405534012802 Walker A/P-loop; other site 405534012803 ATP binding site [chemical binding]; other site 405534012804 Q-loop/lid; other site 405534012805 ABC transporter signature motif; other site 405534012806 Walker B; other site 405534012807 D-loop; other site 405534012808 H-loop/switch region; other site 405534012809 Smr domain; Region: Smr; pfam01713 405534012810 hypothetical protein; Provisional; Region: PRK08609 405534012811 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 405534012812 active site 405534012813 primer binding site [nucleotide binding]; other site 405534012814 NTP binding site [chemical binding]; other site 405534012815 metal binding triad [ion binding]; metal-binding site 405534012816 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 405534012817 active site 405534012818 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 405534012819 Colicin V production protein; Region: Colicin_V; pfam02674 405534012820 cell division protein ZapA; Provisional; Region: PRK14126 405534012821 ribonuclease HIII; Provisional; Region: PRK00996 405534012822 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 405534012823 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 405534012824 RNA/DNA hybrid binding site [nucleotide binding]; other site 405534012825 active site 405534012826 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 405534012827 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 405534012828 putative dimer interface [polypeptide binding]; other site 405534012829 putative anticodon binding site; other site 405534012830 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 405534012831 homodimer interface [polypeptide binding]; other site 405534012832 motif 1; other site 405534012833 motif 2; other site 405534012834 active site 405534012835 motif 3; other site 405534012836 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 405534012837 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 405534012838 putative tRNA-binding site [nucleotide binding]; other site 405534012839 B3/4 domain; Region: B3_4; pfam03483 405534012840 tRNA synthetase B5 domain; Region: B5; smart00874 405534012841 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 405534012842 dimer interface [polypeptide binding]; other site 405534012843 motif 1; other site 405534012844 motif 3; other site 405534012845 motif 2; other site 405534012846 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 405534012847 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 405534012848 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 405534012849 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 405534012850 dimer interface [polypeptide binding]; other site 405534012851 motif 1; other site 405534012852 active site 405534012853 motif 2; other site 405534012854 motif 3; other site 405534012855 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 405534012856 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 405534012857 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 405534012858 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 405534012859 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405534012860 Zn2+ binding site [ion binding]; other site 405534012861 Mg2+ binding site [ion binding]; other site 405534012862 CAAX protease self-immunity; Region: Abi; pfam02517 405534012863 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 405534012864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534012865 putative substrate translocation pore; other site 405534012866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534012867 HlyD family secretion protein; Region: HlyD_3; pfam13437 405534012868 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534012869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534012870 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 405534012871 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 405534012872 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 405534012873 oligomer interface [polypeptide binding]; other site 405534012874 active site 405534012875 metal binding site [ion binding]; metal-binding site 405534012876 dUTPase; Region: dUTPase_2; pfam08761 405534012877 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 405534012878 active site 405534012879 homodimer interface [polypeptide binding]; other site 405534012880 metal binding site [ion binding]; metal-binding site 405534012881 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 405534012882 23S rRNA binding site [nucleotide binding]; other site 405534012883 L21 binding site [polypeptide binding]; other site 405534012884 L13 binding site [polypeptide binding]; other site 405534012885 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 405534012886 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 405534012887 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 405534012888 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 405534012889 Ribosomal protein L20 leader 405534012890 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 405534012891 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 405534012892 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 405534012893 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 405534012894 active site 405534012895 dimer interface [polypeptide binding]; other site 405534012896 motif 1; other site 405534012897 motif 2; other site 405534012898 motif 3; other site 405534012899 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 405534012900 anticodon binding site; other site 405534012901 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 405534012902 primosomal protein DnaI; Reviewed; Region: PRK08939 405534012903 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 405534012904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534012905 Walker A motif; other site 405534012906 ATP binding site [chemical binding]; other site 405534012907 Walker B motif; other site 405534012908 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 405534012909 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 405534012910 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 405534012911 ATP cone domain; Region: ATP-cone; pfam03477 405534012912 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 405534012913 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 405534012914 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 405534012915 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 405534012916 dephospho-CoA kinase; Region: TIGR00152 405534012917 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 405534012918 CoA-binding site [chemical binding]; other site 405534012919 ATP-binding [chemical binding]; other site 405534012920 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 405534012921 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 405534012922 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 405534012923 DNA binding site [nucleotide binding] 405534012924 catalytic residue [active] 405534012925 H2TH interface [polypeptide binding]; other site 405534012926 putative catalytic residues [active] 405534012927 turnover-facilitating residue; other site 405534012928 intercalation triad [nucleotide binding]; other site 405534012929 8OG recognition residue [nucleotide binding]; other site 405534012930 putative reading head residues; other site 405534012931 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 405534012932 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 405534012933 DNA polymerase I; Provisional; Region: PRK05755 405534012934 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 405534012935 active site 405534012936 metal binding site 1 [ion binding]; metal-binding site 405534012937 putative 5' ssDNA interaction site; other site 405534012938 metal binding site 3; metal-binding site 405534012939 metal binding site 2 [ion binding]; metal-binding site 405534012940 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 405534012941 putative DNA binding site [nucleotide binding]; other site 405534012942 putative metal binding site [ion binding]; other site 405534012943 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 405534012944 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 405534012945 active site 405534012946 DNA binding site [nucleotide binding] 405534012947 catalytic site [active] 405534012948 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534012949 dimerization interface [polypeptide binding]; other site 405534012950 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 405534012951 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405534012952 putative active site [active] 405534012953 heme pocket [chemical binding]; other site 405534012954 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534012955 dimer interface [polypeptide binding]; other site 405534012956 phosphorylation site [posttranslational modification] 405534012957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534012958 ATP binding site [chemical binding]; other site 405534012959 Mg2+ binding site [ion binding]; other site 405534012960 G-X-G motif; other site 405534012961 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534012962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534012963 active site 405534012964 phosphorylation site [posttranslational modification] 405534012965 intermolecular recognition site; other site 405534012966 dimerization interface [polypeptide binding]; other site 405534012967 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534012968 DNA binding site [nucleotide binding] 405534012969 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 405534012970 active site 2 [active] 405534012971 active site 1 [active] 405534012972 malate dehydrogenase; Reviewed; Region: PRK06223 405534012973 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 405534012974 NAD(P) binding site [chemical binding]; other site 405534012975 dimer interface [polypeptide binding]; other site 405534012976 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405534012977 substrate binding site [chemical binding]; other site 405534012978 isocitrate dehydrogenase; Reviewed; Region: PRK07006 405534012979 isocitrate dehydrogenase; Validated; Region: PRK07362 405534012980 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 405534012981 dimer interface [polypeptide binding]; other site 405534012982 Citrate synthase; Region: Citrate_synt; pfam00285 405534012983 active site 405534012984 citrylCoA binding site [chemical binding]; other site 405534012985 oxalacetate/citrate binding site [chemical binding]; other site 405534012986 coenzyme A binding site [chemical binding]; other site 405534012987 catalytic triad [active] 405534012988 Protein of unknown function (DUF441); Region: DUF441; pfam04284 405534012989 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 405534012990 Domain of unknown function DUF20; Region: UPF0118; pfam01594 405534012991 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 405534012992 pyruvate kinase; Provisional; Region: PRK06354 405534012993 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 405534012994 domain interfaces; other site 405534012995 active site 405534012996 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 405534012997 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 405534012998 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 405534012999 active site 405534013000 ADP/pyrophosphate binding site [chemical binding]; other site 405534013001 dimerization interface [polypeptide binding]; other site 405534013002 allosteric effector site; other site 405534013003 fructose-1,6-bisphosphate binding site; other site 405534013004 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 405534013005 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 405534013006 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 405534013007 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 405534013008 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 405534013009 Transcriptional regulators [Transcription]; Region: FadR; COG2186 405534013010 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405534013011 DNA-binding site [nucleotide binding]; DNA binding site 405534013012 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 405534013013 Malic enzyme, N-terminal domain; Region: malic; pfam00390 405534013014 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 405534013015 putative NAD(P) binding site [chemical binding]; other site 405534013016 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 405534013017 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 405534013018 active site 405534013019 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 405534013020 generic binding surface II; other site 405534013021 generic binding surface I; other site 405534013022 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 405534013023 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 405534013024 DHH family; Region: DHH; pfam01368 405534013025 DHHA1 domain; Region: DHHA1; pfam02272 405534013026 YtpI-like protein; Region: YtpI; pfam14007 405534013027 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 405534013028 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 405534013029 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405534013030 DNA-binding site [nucleotide binding]; DNA binding site 405534013031 DRTGG domain; Region: DRTGG; pfam07085 405534013032 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 405534013033 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 405534013034 active site 2 [active] 405534013035 active site 1 [active] 405534013036 metal-dependent hydrolase; Provisional; Region: PRK00685 405534013037 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 405534013038 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 405534013039 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 405534013040 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 405534013041 active site 405534013042 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 405534013043 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 405534013044 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 405534013045 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 405534013046 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405534013047 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 405534013048 DNA binding residues [nucleotide binding] 405534013049 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 405534013050 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405534013051 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 405534013052 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 405534013053 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 405534013054 hexamer interface [polypeptide binding]; other site 405534013055 ligand binding site [chemical binding]; other site 405534013056 putative active site [active] 405534013057 NAD(P) binding site [chemical binding]; other site 405534013058 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 405534013059 classical (c) SDRs; Region: SDR_c; cd05233 405534013060 NAD(P) binding site [chemical binding]; other site 405534013061 active site 405534013062 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 405534013063 Ligand Binding Site [chemical binding]; other site 405534013064 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534013065 dimerization interface [polypeptide binding]; other site 405534013066 putative DNA binding site [nucleotide binding]; other site 405534013067 putative Zn2+ binding site [ion binding]; other site 405534013068 H+ Antiporter protein; Region: 2A0121; TIGR00900 405534013069 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 405534013070 active site 405534013071 substrate binding site [chemical binding]; other site 405534013072 ATP binding site [chemical binding]; other site 405534013073 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 405534013074 activation loop (A-loop); other site 405534013075 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 405534013076 active site 405534013077 zinc binding site [ion binding]; other site 405534013078 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405534013079 DinB superfamily; Region: DinB_2; pfam12867 405534013080 argininosuccinate lyase; Provisional; Region: PRK00855 405534013081 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 405534013082 active sites [active] 405534013083 tetramer interface [polypeptide binding]; other site 405534013084 argininosuccinate synthase; Provisional; Region: PRK13820 405534013085 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 405534013086 ANP binding site [chemical binding]; other site 405534013087 Substrate Binding Site II [chemical binding]; other site 405534013088 Substrate Binding Site I [chemical binding]; other site 405534013089 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405534013090 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405534013091 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405534013092 EcsC protein family; Region: EcsC; pfam12787 405534013093 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 405534013094 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 405534013095 nudix motif; other site 405534013096 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 405534013097 propionate/acetate kinase; Provisional; Region: PRK12379 405534013098 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 405534013099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534013100 S-adenosylmethionine binding site [chemical binding]; other site 405534013101 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 405534013102 dimer interface [polypeptide binding]; other site 405534013103 catalytic triad [active] 405534013104 peroxidatic and resolving cysteines [active] 405534013105 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 405534013106 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 405534013107 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 405534013108 ATP-NAD kinase; Region: NAD_kinase; pfam01513 405534013109 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 405534013110 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 405534013111 active site 405534013112 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534013113 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 405534013114 dimer interface [polypeptide binding]; other site 405534013115 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 405534013116 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 405534013117 active site 405534013118 acyl-activating enzyme (AAE) consensus motif; other site 405534013119 putative CoA binding site [chemical binding]; other site 405534013120 AMP binding site [chemical binding]; other site 405534013121 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405534013122 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 405534013123 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 405534013124 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 405534013125 Ligand Binding Site [chemical binding]; other site 405534013126 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 405534013127 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 405534013128 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405534013129 catalytic residue [active] 405534013130 septation ring formation regulator EzrA; Provisional; Region: PRK04778 405534013131 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405534013132 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405534013133 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405534013134 dimerization interface [polypeptide binding]; other site 405534013135 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405534013136 EamA-like transporter family; Region: EamA; pfam00892 405534013137 EamA-like transporter family; Region: EamA; pfam00892 405534013138 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534013139 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534013140 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 405534013141 GAF domain; Region: GAF_2; pfam13185 405534013142 methionine gamma-lyase; Provisional; Region: PRK06767 405534013143 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 405534013144 homodimer interface [polypeptide binding]; other site 405534013145 substrate-cofactor binding pocket; other site 405534013146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534013147 catalytic residue [active] 405534013148 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 405534013149 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 405534013150 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405534013151 RNA binding surface [nucleotide binding]; other site 405534013152 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 405534013153 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 405534013154 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 405534013155 active site 405534013156 HIGH motif; other site 405534013157 dimer interface [polypeptide binding]; other site 405534013158 KMSKS motif; other site 405534013159 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405534013160 RNA binding surface [nucleotide binding]; other site 405534013161 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 405534013162 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405534013163 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405534013164 DNA binding residues [nucleotide binding] 405534013165 acetyl-CoA synthetase; Provisional; Region: PRK04319 405534013166 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 405534013167 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 405534013168 active site 405534013169 acyl-activating enzyme (AAE) consensus motif; other site 405534013170 putative CoA binding site [chemical binding]; other site 405534013171 AMP binding site [chemical binding]; other site 405534013172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405534013173 Coenzyme A binding pocket [chemical binding]; other site 405534013174 FOG: CBS domain [General function prediction only]; Region: COG0517 405534013175 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 405534013176 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 405534013177 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 405534013178 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 405534013179 active site 405534013180 Zn binding site [ion binding]; other site 405534013181 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405534013182 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534013183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534013184 active site 405534013185 phosphorylation site [posttranslational modification] 405534013186 intermolecular recognition site; other site 405534013187 dimerization interface [polypeptide binding]; other site 405534013188 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534013189 DNA binding site [nucleotide binding] 405534013190 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534013191 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534013192 dimerization interface [polypeptide binding]; other site 405534013193 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534013194 dimer interface [polypeptide binding]; other site 405534013195 phosphorylation site [posttranslational modification] 405534013196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534013197 ATP binding site [chemical binding]; other site 405534013198 Mg2+ binding site [ion binding]; other site 405534013199 G-X-G motif; other site 405534013200 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 405534013201 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405534013202 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 405534013203 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 405534013204 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 405534013205 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 405534013206 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 405534013207 catabolite control protein A; Region: ccpA; TIGR01481 405534013208 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405534013209 DNA binding site [nucleotide binding] 405534013210 domain linker motif; other site 405534013211 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 405534013212 dimerization interface [polypeptide binding]; other site 405534013213 effector binding site; other site 405534013214 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 405534013215 putative dimer interface [polypeptide binding]; other site 405534013216 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 405534013217 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 405534013218 putative dimer interface [polypeptide binding]; other site 405534013219 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 405534013220 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 405534013221 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 405534013222 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 405534013223 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 405534013224 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405534013225 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534013226 Coenzyme A binding pocket [chemical binding]; other site 405534013227 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405534013228 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405534013229 Coenzyme A binding pocket [chemical binding]; other site 405534013230 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 405534013231 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 405534013232 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405534013233 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405534013234 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 405534013235 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 405534013236 active site 405534013237 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 405534013238 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 405534013239 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 405534013240 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 405534013241 putative tRNA-binding site [nucleotide binding]; other site 405534013242 hypothetical protein; Provisional; Region: PRK13668 405534013243 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405534013244 catalytic residues [active] 405534013245 NTPase; Reviewed; Region: PRK03114 405534013246 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 405534013247 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 405534013248 oligomer interface [polypeptide binding]; other site 405534013249 active site 405534013250 metal binding site [ion binding]; metal-binding site 405534013251 Predicted small secreted protein [Function unknown]; Region: COG5584 405534013252 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405534013253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534013254 S-adenosylmethionine binding site [chemical binding]; other site 405534013255 YtzH-like protein; Region: YtzH; pfam14165 405534013256 Phosphotransferase enzyme family; Region: APH; pfam01636 405534013257 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 405534013258 active site 405534013259 substrate binding site [chemical binding]; other site 405534013260 ATP binding site [chemical binding]; other site 405534013261 pullulanase, type I; Region: pulA_typeI; TIGR02104 405534013262 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 405534013263 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 405534013264 Ca binding site [ion binding]; other site 405534013265 active site 405534013266 catalytic site [active] 405534013267 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 405534013268 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 405534013269 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 405534013270 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 405534013271 dipeptidase PepV; Reviewed; Region: PRK07318 405534013272 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 405534013273 active site 405534013274 metal binding site [ion binding]; metal-binding site 405534013275 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 405534013276 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 405534013277 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405534013278 RNA binding surface [nucleotide binding]; other site 405534013279 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 405534013280 active site 405534013281 uracil binding [chemical binding]; other site 405534013282 stage V sporulation protein B; Region: spore_V_B; TIGR02900 405534013283 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405534013284 HI0933-like protein; Region: HI0933_like; pfam03486 405534013285 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405534013286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534013287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534013288 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534013289 dimerization interface [polypeptide binding]; other site 405534013290 putative DNA binding site [nucleotide binding]; other site 405534013291 putative Zn2+ binding site [ion binding]; other site 405534013292 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 405534013293 putative hydrophobic ligand binding site [chemical binding]; other site 405534013294 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 405534013295 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 405534013296 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 405534013297 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 405534013298 glucose-1-dehydrogenase; Provisional; Region: PRK08936 405534013299 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 405534013300 NAD binding site [chemical binding]; other site 405534013301 homodimer interface [polypeptide binding]; other site 405534013302 active site 405534013303 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 405534013304 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 405534013305 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 405534013306 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 405534013307 MoaE interaction surface [polypeptide binding]; other site 405534013308 MoeB interaction surface [polypeptide binding]; other site 405534013309 thiocarboxylated glycine; other site 405534013310 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 405534013311 MoaE homodimer interface [polypeptide binding]; other site 405534013312 MoaD interaction [polypeptide binding]; other site 405534013313 active site residues [active] 405534013314 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 405534013315 Walker A motif; other site 405534013316 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 405534013317 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 405534013318 dimer interface [polypeptide binding]; other site 405534013319 putative functional site; other site 405534013320 putative MPT binding site; other site 405534013321 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 405534013322 trimer interface [polypeptide binding]; other site 405534013323 dimer interface [polypeptide binding]; other site 405534013324 putative active site [active] 405534013325 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 405534013326 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 405534013327 ATP binding site [chemical binding]; other site 405534013328 substrate interface [chemical binding]; other site 405534013329 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 405534013330 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405534013331 FeS/SAM binding site; other site 405534013332 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 405534013333 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 405534013334 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 405534013335 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405534013336 active site residue [active] 405534013337 homoserine O-acetyltransferase; Provisional; Region: PRK06765 405534013338 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 405534013339 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405534013340 Spore germination protein; Region: Spore_permease; pfam03845 405534013341 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405534013342 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405534013343 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 405534013344 putative nucleotide binding site [chemical binding]; other site 405534013345 putative metal binding site [ion binding]; other site 405534013346 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 405534013347 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 405534013348 HIGH motif; other site 405534013349 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 405534013350 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 405534013351 active site 405534013352 KMSKS motif; other site 405534013353 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 405534013354 tRNA binding surface [nucleotide binding]; other site 405534013355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534013356 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534013357 putative substrate translocation pore; other site 405534013358 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 405534013359 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 405534013360 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 405534013361 TrkA-C domain; Region: TrkA_C; pfam02080 405534013362 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 405534013363 Int/Topo IB signature motif; other site 405534013364 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405534013365 FtsX-like permease family; Region: FtsX; pfam02687 405534013366 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405534013367 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405534013368 Walker A/P-loop; other site 405534013369 ATP binding site [chemical binding]; other site 405534013370 Q-loop/lid; other site 405534013371 ABC transporter signature motif; other site 405534013372 Walker B; other site 405534013373 D-loop; other site 405534013374 H-loop/switch region; other site 405534013375 Predicted membrane protein [Function unknown]; Region: COG2311 405534013376 Protein of unknown function (DUF418); Region: DUF418; cl12135 405534013377 Protein of unknown function (DUF418); Region: DUF418; pfam04235 405534013378 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 405534013379 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 405534013380 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405534013381 FeS/SAM binding site; other site 405534013382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534013383 S-adenosylmethionine binding site [chemical binding]; other site 405534013384 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 405534013385 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405534013386 Walker A/P-loop; other site 405534013387 ATP binding site [chemical binding]; other site 405534013388 Q-loop/lid; other site 405534013389 ABC transporter signature motif; other site 405534013390 Walker B; other site 405534013391 D-loop; other site 405534013392 H-loop/switch region; other site 405534013393 aspartate racemase; Region: asp_race; TIGR00035 405534013394 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 405534013395 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 405534013396 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 405534013397 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 405534013398 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 405534013399 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405534013400 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405534013401 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 405534013402 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 405534013403 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 405534013404 trimer interface [polypeptide binding]; other site 405534013405 putative metal binding site [ion binding]; other site 405534013406 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405534013407 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 405534013408 active site 405534013409 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405534013410 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 405534013411 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 405534013412 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 405534013413 GTP binding site; other site 405534013414 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 405534013415 MPT binding site; other site 405534013416 trimer interface [polypeptide binding]; other site 405534013417 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405534013418 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405534013419 S-adenosylmethionine synthetase; Validated; Region: PRK05250 405534013420 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 405534013421 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 405534013422 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 405534013423 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 405534013424 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 405534013425 active site 405534013426 substrate-binding site [chemical binding]; other site 405534013427 metal-binding site [ion binding] 405534013428 ATP binding site [chemical binding]; other site 405534013429 ATP synthase I chain; Region: ATP_synt_I; pfam03899 405534013430 EamA-like transporter family; Region: EamA; pfam00892 405534013431 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405534013432 EamA-like transporter family; Region: EamA; pfam00892 405534013433 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 405534013434 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534013435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534013436 ATP binding site [chemical binding]; other site 405534013437 Mg2+ binding site [ion binding]; other site 405534013438 G-X-G motif; other site 405534013439 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534013440 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534013441 dimer interface [polypeptide binding]; other site 405534013442 phosphorylation site [posttranslational modification] 405534013443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534013444 ATP binding site [chemical binding]; other site 405534013445 Mg2+ binding site [ion binding]; other site 405534013446 G-X-G motif; other site 405534013447 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405534013448 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405534013449 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 405534013450 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 405534013451 Sulfatase; Region: Sulfatase; pfam00884 405534013452 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 405534013453 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 405534013454 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 405534013455 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 405534013456 NMT1-like family; Region: NMT1_2; pfam13379 405534013457 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 405534013458 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 405534013459 Walker A/P-loop; other site 405534013460 ATP binding site [chemical binding]; other site 405534013461 Q-loop/lid; other site 405534013462 ABC transporter signature motif; other site 405534013463 Walker B; other site 405534013464 D-loop; other site 405534013465 H-loop/switch region; other site 405534013466 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 405534013467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534013468 dimer interface [polypeptide binding]; other site 405534013469 conserved gate region; other site 405534013470 putative PBP binding loops; other site 405534013471 ABC-ATPase subunit interface; other site 405534013472 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 405534013473 active site 405534013474 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 405534013475 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534013476 motif II; other site 405534013477 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 405534013478 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 405534013479 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 405534013480 nudix motif; other site 405534013481 S-ribosylhomocysteinase; Provisional; Region: PRK02260 405534013482 Haemolytic domain; Region: Haemolytic; pfam01809 405534013483 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 405534013484 active site clefts [active] 405534013485 zinc binding site [ion binding]; other site 405534013486 dimer interface [polypeptide binding]; other site 405534013487 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 405534013488 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 405534013489 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 405534013490 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 405534013491 S-layer homology domain; Region: SLH; pfam00395 405534013492 S-layer homology domain; Region: SLH; pfam00395 405534013493 S-layer homology domain; Region: SLH; pfam00395 405534013494 Excalibur calcium-binding domain; Region: Excalibur; smart00894 405534013495 Uncharacterized conserved protein [Function unknown]; Region: COG1434 405534013496 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 405534013497 putative active site [active] 405534013498 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405534013499 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405534013500 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405534013501 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405534013502 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 405534013503 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 405534013504 Predicted membrane protein [Function unknown]; Region: COG3766 405534013505 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 405534013506 hypothetical protein; Provisional; Region: PRK12473 405534013507 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 405534013508 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 405534013509 G1 box; other site 405534013510 GTP/Mg2+ binding site [chemical binding]; other site 405534013511 Switch I region; other site 405534013512 G2 box; other site 405534013513 G3 box; other site 405534013514 Switch II region; other site 405534013515 G4 box; other site 405534013516 G5 box; other site 405534013517 Nucleoside recognition; Region: Gate; pfam07670 405534013518 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 405534013519 Nucleoside recognition; Region: Gate; pfam07670 405534013520 FeoA domain; Region: FeoA; pfam04023 405534013521 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 405534013522 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534013523 dimerization interface [polypeptide binding]; other site 405534013524 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534013525 dimer interface [polypeptide binding]; other site 405534013526 phosphorylation site [posttranslational modification] 405534013527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534013528 ATP binding site [chemical binding]; other site 405534013529 Mg2+ binding site [ion binding]; other site 405534013530 G-X-G motif; other site 405534013531 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534013532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534013533 active site 405534013534 phosphorylation site [posttranslational modification] 405534013535 intermolecular recognition site; other site 405534013536 dimerization interface [polypeptide binding]; other site 405534013537 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534013538 DNA binding site [nucleotide binding] 405534013539 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 405534013540 active site 405534013541 catalytic site [active] 405534013542 S-layer homology domain; Region: SLH; pfam00395 405534013543 S-layer homology domain; Region: SLH; pfam00395 405534013544 S-layer homology domain; Region: SLH; pfam00395 405534013545 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 405534013546 putative active site [active] 405534013547 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 405534013548 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405534013549 active site 405534013550 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 405534013551 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 405534013552 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 405534013553 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 405534013554 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405534013555 FtsX-like permease family; Region: FtsX; pfam02687 405534013556 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405534013557 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405534013558 Walker A/P-loop; other site 405534013559 ATP binding site [chemical binding]; other site 405534013560 Q-loop/lid; other site 405534013561 ABC transporter signature motif; other site 405534013562 Walker B; other site 405534013563 D-loop; other site 405534013564 H-loop/switch region; other site 405534013565 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405534013566 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 405534013567 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405534013568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534013569 S-adenosylmethionine binding site [chemical binding]; other site 405534013570 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 405534013571 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405534013572 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405534013573 YolD-like protein; Region: YolD; pfam08863 405534013574 FtsX-like permease family; Region: FtsX; pfam02687 405534013575 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405534013576 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405534013577 Walker A/P-loop; other site 405534013578 ATP binding site [chemical binding]; other site 405534013579 Q-loop/lid; other site 405534013580 ABC transporter signature motif; other site 405534013581 Walker B; other site 405534013582 D-loop; other site 405534013583 H-loop/switch region; other site 405534013584 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405534013585 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405534013586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 405534013587 Predicted integral membrane protein [Function unknown]; Region: COG5658 405534013588 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 405534013589 SdpI/YhfL protein family; Region: SdpI; pfam13630 405534013590 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534013591 dimerization interface [polypeptide binding]; other site 405534013592 putative DNA binding site [nucleotide binding]; other site 405534013593 putative Zn2+ binding site [ion binding]; other site 405534013594 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534013595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534013596 active site 405534013597 phosphorylation site [posttranslational modification] 405534013598 intermolecular recognition site; other site 405534013599 dimerization interface [polypeptide binding]; other site 405534013600 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534013601 DNA binding site [nucleotide binding] 405534013602 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534013603 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 405534013604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534013605 ATP binding site [chemical binding]; other site 405534013606 Mg2+ binding site [ion binding]; other site 405534013607 G-X-G motif; other site 405534013608 FtsX-like permease family; Region: FtsX; pfam02687 405534013609 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405534013610 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405534013611 Walker A/P-loop; other site 405534013612 ATP binding site [chemical binding]; other site 405534013613 Q-loop/lid; other site 405534013614 ABC transporter signature motif; other site 405534013615 Walker B; other site 405534013616 D-loop; other site 405534013617 H-loop/switch region; other site 405534013618 FtsX-like permease family; Region: FtsX; pfam02687 405534013619 fructuronate transporter; Provisional; Region: PRK10034; cl15264 405534013620 GntP family permease; Region: GntP_permease; pfam02447 405534013621 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 405534013622 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405534013623 DNA-binding site [nucleotide binding]; DNA binding site 405534013624 UTRA domain; Region: UTRA; pfam07702 405534013625 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405534013626 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 405534013627 substrate binding site [chemical binding]; other site 405534013628 ATP binding site [chemical binding]; other site 405534013629 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 405534013630 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 405534013631 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405534013632 catalytic residue [active] 405534013633 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 405534013634 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 405534013635 active site 405534013636 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 405534013637 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 405534013638 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534013639 dimerization interface [polypeptide binding]; other site 405534013640 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534013641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534013642 dimer interface [polypeptide binding]; other site 405534013643 phosphorylation site [posttranslational modification] 405534013644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534013645 ATP binding site [chemical binding]; other site 405534013646 Mg2+ binding site [ion binding]; other site 405534013647 G-X-G motif; other site 405534013648 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534013649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534013650 active site 405534013651 phosphorylation site [posttranslational modification] 405534013652 intermolecular recognition site; other site 405534013653 dimerization interface [polypeptide binding]; other site 405534013654 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534013655 DNA binding site [nucleotide binding] 405534013656 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 405534013657 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 405534013658 active site 405534013659 octamer interface [polypeptide binding]; other site 405534013660 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 405534013661 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 405534013662 acyl-activating enzyme (AAE) consensus motif; other site 405534013663 putative AMP binding site [chemical binding]; other site 405534013664 putative active site [active] 405534013665 putative CoA binding site [chemical binding]; other site 405534013666 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405534013667 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 405534013668 substrate binding site [chemical binding]; other site 405534013669 oxyanion hole (OAH) forming residues; other site 405534013670 trimer interface [polypeptide binding]; other site 405534013671 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 405534013672 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 405534013673 nucleophilic elbow; other site 405534013674 catalytic triad; other site 405534013675 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 405534013676 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 405534013677 dimer interface [polypeptide binding]; other site 405534013678 tetramer interface [polypeptide binding]; other site 405534013679 PYR/PP interface [polypeptide binding]; other site 405534013680 TPP binding site [chemical binding]; other site 405534013681 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 405534013682 TPP-binding site; other site 405534013683 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 405534013684 chorismate binding enzyme; Region: Chorismate_bind; cl10555 405534013685 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 405534013686 UbiA prenyltransferase family; Region: UbiA; pfam01040 405534013687 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 405534013688 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405534013689 DNA-binding site [nucleotide binding]; DNA binding site 405534013690 RNA-binding motif; other site 405534013691 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 405534013692 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 405534013693 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405534013694 DNA binding residues [nucleotide binding] 405534013695 dimer interface [polypeptide binding]; other site 405534013696 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 405534013697 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 405534013698 active site flap/lid [active] 405534013699 nucleophilic elbow; other site 405534013700 catalytic triad [active] 405534013701 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 405534013702 homodimer interface [polypeptide binding]; other site 405534013703 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 405534013704 active site pocket [active] 405534013705 glycogen synthase; Provisional; Region: glgA; PRK00654 405534013706 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 405534013707 ADP-binding pocket [chemical binding]; other site 405534013708 homodimer interface [polypeptide binding]; other site 405534013709 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 405534013710 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 405534013711 ligand binding site; other site 405534013712 oligomer interface; other site 405534013713 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 405534013714 dimer interface [polypeptide binding]; other site 405534013715 N-terminal domain interface [polypeptide binding]; other site 405534013716 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 405534013717 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 405534013718 ligand binding site; other site 405534013719 oligomer interface; other site 405534013720 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 405534013721 dimer interface [polypeptide binding]; other site 405534013722 N-terminal domain interface [polypeptide binding]; other site 405534013723 sulfate 1 binding site; other site 405534013724 glycogen branching enzyme; Provisional; Region: PRK12313 405534013725 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 405534013726 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 405534013727 active site 405534013728 catalytic site [active] 405534013729 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 405534013730 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 405534013731 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 405534013732 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 405534013733 putative active site [active] 405534013734 catalytic triad [active] 405534013735 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 405534013736 PA/protease domain interface [polypeptide binding]; other site 405534013737 putative integrin binding motif; other site 405534013738 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 405534013739 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 405534013740 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 405534013741 dockerin binding interface; other site 405534013742 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 405534013743 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 405534013744 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405534013745 NAD binding site [chemical binding]; other site 405534013746 dimer interface [polypeptide binding]; other site 405534013747 substrate binding site [chemical binding]; other site 405534013748 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 405534013749 MgtC family; Region: MgtC; pfam02308 405534013750 Ion channel; Region: Ion_trans_2; pfam07885 405534013751 TrkA-N domain; Region: TrkA_N; pfam02254 405534013752 YugN-like family; Region: YugN; pfam08868 405534013753 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 405534013754 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 405534013755 active site 405534013756 dimer interface [polypeptide binding]; other site 405534013757 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 405534013758 dimer interface [polypeptide binding]; other site 405534013759 active site 405534013760 Domain of unknown function (DUF378); Region: DUF378; pfam04070 405534013761 general stress protein 13; Validated; Region: PRK08059 405534013762 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 405534013763 RNA binding site [nucleotide binding]; other site 405534013764 hypothetical protein; Validated; Region: PRK07682 405534013765 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405534013766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534013767 homodimer interface [polypeptide binding]; other site 405534013768 catalytic residue [active] 405534013769 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 405534013770 AsnC family; Region: AsnC_trans_reg; pfam01037 405534013771 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 405534013772 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 405534013773 dimerization interface [polypeptide binding]; other site 405534013774 ligand binding site [chemical binding]; other site 405534013775 NADP binding site [chemical binding]; other site 405534013776 catalytic site [active] 405534013777 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 405534013778 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405534013779 nucleophilic elbow; other site 405534013780 catalytic triad; other site 405534013781 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 405534013782 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 405534013783 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405534013784 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534013785 homodimer interface [polypeptide binding]; other site 405534013786 catalytic residue [active] 405534013787 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 405534013788 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 405534013789 E-class dimer interface [polypeptide binding]; other site 405534013790 P-class dimer interface [polypeptide binding]; other site 405534013791 active site 405534013792 Cu2+ binding site [ion binding]; other site 405534013793 Zn2+ binding site [ion binding]; other site 405534013794 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 405534013795 Kinase associated protein B; Region: KapB; pfam08810 405534013796 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 405534013797 active site 405534013798 catalytic site [active] 405534013799 substrate binding site [chemical binding]; other site 405534013800 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 405534013801 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 405534013802 transmembrane helices; other site 405534013803 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 405534013804 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 405534013805 active site 405534013806 glycyl-tRNA synthetase; Provisional; Region: PRK04173 405534013807 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 405534013808 motif 1; other site 405534013809 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 405534013810 active site 405534013811 motif 2; other site 405534013812 motif 3; other site 405534013813 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 405534013814 anticodon binding site; other site 405534013815 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 405534013816 CoenzymeA binding site [chemical binding]; other site 405534013817 subunit interaction site [polypeptide binding]; other site 405534013818 PHB binding site; other site 405534013819 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 405534013820 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 405534013821 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 405534013822 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 405534013823 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 405534013824 active site 405534013825 tetramer interface; other site 405534013826 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 405534013827 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 405534013828 active site 405534013829 substrate binding site [chemical binding]; other site 405534013830 metal binding site [ion binding]; metal-binding site 405534013831 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 405534013832 Uncharacterized conserved protein [Function unknown]; Region: COG1624 405534013833 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 405534013834 multifunctional aminopeptidase A; Provisional; Region: PRK00913 405534013835 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 405534013836 interface (dimer of trimers) [polypeptide binding]; other site 405534013837 Substrate-binding/catalytic site; other site 405534013838 Zn-binding sites [ion binding]; other site 405534013839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 405534013840 Putative membrane protein; Region: YuiB; pfam14068 405534013841 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 405534013842 nudix motif; other site 405534013843 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 405534013844 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405534013845 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 405534013846 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405534013847 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405534013848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 405534013849 H+ Antiporter protein; Region: 2A0121; TIGR00900 405534013850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534013851 putative substrate translocation pore; other site 405534013852 Helix-turn-helix domain; Region: HTH_36; pfam13730 405534013853 Protein of unknown function (DUF523); Region: DUF523; pfam04463 405534013854 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405534013855 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405534013856 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405534013857 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 405534013858 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 405534013859 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 405534013860 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 405534013861 hypothetical protein; Provisional; Region: PRK13669 405534013862 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 405534013863 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405534013864 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 405534013865 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405534013866 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534013867 Walker A/P-loop; other site 405534013868 ATP binding site [chemical binding]; other site 405534013869 Q-loop/lid; other site 405534013870 ABC transporter signature motif; other site 405534013871 Walker B; other site 405534013872 D-loop; other site 405534013873 H-loop/switch region; other site 405534013874 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 405534013875 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 405534013876 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 405534013877 PhnA protein; Region: PhnA; pfam03831 405534013878 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 405534013879 PQQ-like domain; Region: PQQ_2; pfam13360 405534013880 PQQ-like domain; Region: PQQ_2; pfam13360 405534013881 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 405534013882 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 405534013883 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 405534013884 CAAX protease self-immunity; Region: Abi; pfam02517 405534013885 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 405534013886 active site 405534013887 NTP binding site [chemical binding]; other site 405534013888 metal binding triad [ion binding]; metal-binding site 405534013889 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 405534013890 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 405534013891 NifU-like domain; Region: NifU; pfam01106 405534013892 spore coat protein YutH; Region: spore_yutH; TIGR02905 405534013893 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 405534013894 tetramer interfaces [polypeptide binding]; other site 405534013895 binuclear metal-binding site [ion binding]; other site 405534013896 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405534013897 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 405534013898 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405534013899 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 405534013900 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534013901 active site 405534013902 motif I; other site 405534013903 motif II; other site 405534013904 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534013905 Predicted transcriptional regulator [Transcription]; Region: COG2345 405534013906 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534013907 putative Zn2+ binding site [ion binding]; other site 405534013908 putative DNA binding site [nucleotide binding]; other site 405534013909 Uncharacterized conserved protein [Function unknown]; Region: COG2445 405534013910 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 405534013911 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 405534013912 putative active site [active] 405534013913 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 405534013914 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 405534013915 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405534013916 RNA binding surface [nucleotide binding]; other site 405534013917 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 405534013918 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 405534013919 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405534013920 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 405534013921 DNA binding residues [nucleotide binding] 405534013922 dimer interface [polypeptide binding]; other site 405534013923 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 405534013924 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 405534013925 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405534013926 catalytic core [active] 405534013927 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 405534013928 putative deacylase active site [active] 405534013929 lipoyl synthase; Provisional; Region: PRK05481 405534013930 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405534013931 FeS/SAM binding site; other site 405534013932 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405534013933 Peptidase family M23; Region: Peptidase_M23; pfam01551 405534013934 sporulation protein YunB; Region: spo_yunB; TIGR02832 405534013935 Uncharacterized conserved protein [Function unknown]; Region: COG3377 405534013936 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 405534013937 FeS assembly protein SufB; Region: sufB; TIGR01980 405534013938 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 405534013939 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 405534013940 trimerization site [polypeptide binding]; other site 405534013941 active site 405534013942 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 405534013943 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 405534013944 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405534013945 catalytic residue [active] 405534013946 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 405534013947 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 405534013948 FeS assembly protein SufD; Region: sufD; TIGR01981 405534013949 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 405534013950 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 405534013951 Walker A/P-loop; other site 405534013952 ATP binding site [chemical binding]; other site 405534013953 Q-loop/lid; other site 405534013954 ABC transporter signature motif; other site 405534013955 Walker B; other site 405534013956 D-loop; other site 405534013957 H-loop/switch region; other site 405534013958 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 405534013959 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 405534013960 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 405534013961 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 405534013962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405534013963 ABC-ATPase subunit interface; other site 405534013964 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 405534013965 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 405534013966 Walker A/P-loop; other site 405534013967 ATP binding site [chemical binding]; other site 405534013968 Q-loop/lid; other site 405534013969 ABC transporter signature motif; other site 405534013970 Walker B; other site 405534013971 D-loop; other site 405534013972 H-loop/switch region; other site 405534013973 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 405534013974 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405534013975 catalytic residues [active] 405534013976 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 405534013977 putative active site [active] 405534013978 putative metal binding site [ion binding]; other site 405534013979 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 405534013980 lipoyl attachment site [posttranslational modification]; other site 405534013981 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 405534013982 ArsC family; Region: ArsC; pfam03960 405534013983 putative ArsC-like catalytic residues; other site 405534013984 putative TRX-like catalytic residues [active] 405534013985 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 405534013986 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 405534013987 active site 405534013988 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 405534013989 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 405534013990 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 405534013991 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 405534013992 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405534013993 NAD binding site [chemical binding]; other site 405534013994 dimer interface [polypeptide binding]; other site 405534013995 substrate binding site [chemical binding]; other site 405534013996 Coat F domain; Region: Coat_F; pfam07875 405534013997 CAAX protease self-immunity; Region: Abi; pfam02517 405534013998 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534013999 salt bridge; other site 405534014000 non-specific DNA binding site [nucleotide binding]; other site 405534014001 sequence-specific DNA binding site [nucleotide binding]; other site 405534014002 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534014003 WHG domain; Region: WHG; pfam13305 405534014004 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405534014005 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 405534014006 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405534014007 active site 405534014008 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 405534014009 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 405534014010 dimer interface [polypeptide binding]; other site 405534014011 active site 405534014012 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 405534014013 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 405534014014 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 405534014015 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 405534014016 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405534014017 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 405534014018 substrate binding site [chemical binding]; other site 405534014019 oxyanion hole (OAH) forming residues; other site 405534014020 YuzL-like protein; Region: YuzL; pfam14115 405534014021 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405534014022 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 405534014023 Proline dehydrogenase; Region: Pro_dh; cl03282 405534014024 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 405534014025 Domain of unknown function DUF77; Region: DUF77; pfam01910 405534014026 Cache domain; Region: Cache_1; pfam02743 405534014027 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534014028 dimerization interface [polypeptide binding]; other site 405534014029 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405534014030 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405534014031 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405534014032 dimer interface [polypeptide binding]; other site 405534014033 putative CheW interface [polypeptide binding]; other site 405534014034 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405534014035 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 405534014036 Probable transposase; Region: OrfB_IS605; pfam01385 405534014037 Predicted transcriptional regulators [Transcription]; Region: COG1378 405534014038 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 405534014039 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 405534014040 C-terminal domain interface [polypeptide binding]; other site 405534014041 sugar binding site [chemical binding]; other site 405534014042 TQXA domain; Region: TQXA_dom; TIGR03934 405534014043 Cna protein B-type domain; Region: Cna_B; pfam05738 405534014044 Cna protein B-type domain; Region: Cna_B; pfam05738 405534014045 Cna protein B-type domain; Region: Cna_B; pfam05738 405534014046 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 405534014047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534014048 putative substrate translocation pore; other site 405534014049 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 405534014050 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 405534014051 Spore germination protein; Region: Spore_permease; cl17796 405534014052 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 405534014053 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405534014054 MAEBL; Provisional; Region: PTZ00121 405534014055 Homeodomain-like domain; Region: HTH_23; pfam13384 405534014056 putative transposase OrfB; Reviewed; Region: PHA02517 405534014057 HTH-like domain; Region: HTH_21; pfam13276 405534014058 Integrase core domain; Region: rve; pfam00665 405534014059 Integrase core domain; Region: rve_2; pfam13333 405534014060 OxaA-like protein precursor; Validated; Region: PRK01622 405534014061 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405534014062 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405534014063 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405534014064 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405534014065 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405534014066 hypothetical protein; Provisional; Region: PRK06758 405534014067 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 405534014068 active site 405534014069 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534014070 non-specific DNA binding site [nucleotide binding]; other site 405534014071 salt bridge; other site 405534014072 sequence-specific DNA binding site [nucleotide binding]; other site 405534014073 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405534014074 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405534014075 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 405534014076 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405534014077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 405534014078 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534014079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534014080 active site 405534014081 phosphorylation site [posttranslational modification] 405534014082 intermolecular recognition site; other site 405534014083 dimerization interface [polypeptide binding]; other site 405534014084 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534014085 DNA binding site [nucleotide binding] 405534014086 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534014087 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534014088 dimer interface [polypeptide binding]; other site 405534014089 phosphorylation site [posttranslational modification] 405534014090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534014091 ATP binding site [chemical binding]; other site 405534014092 Mg2+ binding site [ion binding]; other site 405534014093 G-X-G motif; other site 405534014094 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405534014095 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 405534014096 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 405534014097 active site 405534014098 HIGH motif; other site 405534014099 KMSKS motif; other site 405534014100 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 405534014101 tRNA binding surface [nucleotide binding]; other site 405534014102 anticodon binding site; other site 405534014103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534014104 S-adenosylmethionine binding site [chemical binding]; other site 405534014105 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534014106 dimerization interface [polypeptide binding]; other site 405534014107 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405534014108 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405534014109 dimer interface [polypeptide binding]; other site 405534014110 putative CheW interface [polypeptide binding]; other site 405534014111 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534014112 dimerization interface [polypeptide binding]; other site 405534014113 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405534014114 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405534014115 dimer interface [polypeptide binding]; other site 405534014116 putative CheW interface [polypeptide binding]; other site 405534014117 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 405534014118 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405534014119 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405534014120 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 405534014121 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 405534014122 active site 405534014123 Zn binding site [ion binding]; other site 405534014124 Pirin-related protein [General function prediction only]; Region: COG1741 405534014125 Pirin; Region: Pirin; pfam02678 405534014126 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405534014127 MarR family; Region: MarR_2; pfam12802 405534014128 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 405534014129 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 405534014130 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 405534014131 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 405534014132 TrkA-C domain; Region: TrkA_C; pfam02080 405534014133 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405534014134 amino acid carrier protein; Region: agcS; TIGR00835 405534014135 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 405534014136 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 405534014137 dimerization interface [polypeptide binding]; other site 405534014138 DPS ferroxidase diiron center [ion binding]; other site 405534014139 ion pore; other site 405534014140 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 405534014141 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 405534014142 metal binding site [ion binding]; metal-binding site 405534014143 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 405534014144 Ferritin-like domain; Region: Ferritin; pfam00210 405534014145 ferroxidase diiron center [ion binding]; other site 405534014146 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405534014147 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405534014148 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405534014149 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405534014150 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405534014151 Nucleoside recognition; Region: Gate; pfam07670 405534014152 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405534014153 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405534014154 amino acid carrier protein; Region: agcS; TIGR00835 405534014155 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405534014156 amino acid carrier protein; Region: agcS; TIGR00835 405534014157 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 405534014158 NADH(P)-binding; Region: NAD_binding_10; pfam13460 405534014159 NAD binding site [chemical binding]; other site 405534014160 substrate binding site [chemical binding]; other site 405534014161 putative active site [active] 405534014162 Homeodomain-like domain; Region: HTH_23; pfam13384 405534014163 putative transposase OrfB; Reviewed; Region: PHA02517 405534014164 HTH-like domain; Region: HTH_21; pfam13276 405534014165 Integrase core domain; Region: rve; pfam00665 405534014166 Integrase core domain; Region: rve_2; pfam13333 405534014167 Peptidase M60-like family; Region: M60-like; pfam13402 405534014168 TQXA domain; Region: TQXA_dom; TIGR03934 405534014169 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405534014170 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405534014171 active site 405534014172 catalytic tetrad [active] 405534014173 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 405534014174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534014175 putative substrate translocation pore; other site 405534014176 Predicted transcriptional regulators [Transcription]; Region: COG1733 405534014177 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534014178 dimerization interface [polypeptide binding]; other site 405534014179 putative DNA binding site [nucleotide binding]; other site 405534014180 putative Zn2+ binding site [ion binding]; other site 405534014181 Uncharacterized conserved protein [Function unknown]; Region: COG2427 405534014182 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 405534014183 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405534014184 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 405534014185 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 405534014186 active site 405534014187 HIGH motif; other site 405534014188 dimer interface [polypeptide binding]; other site 405534014189 KMSKS motif; other site 405534014190 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405534014191 RNA binding surface [nucleotide binding]; other site 405534014192 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 405534014193 FAD binding domain; Region: FAD_binding_4; pfam01565 405534014194 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 405534014195 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 405534014196 SET domain; Region: SET; pfam00856 405534014197 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 405534014198 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405534014199 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405534014200 dimer interface [polypeptide binding]; other site 405534014201 putative CheW interface [polypeptide binding]; other site 405534014202 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 405534014203 putative phosphate binding site [ion binding]; other site 405534014204 camphor resistance protein CrcB; Provisional; Region: PRK14219 405534014205 camphor resistance protein CrcB; Provisional; Region: PRK14205 405534014206 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 405534014207 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 405534014208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534014209 H+ Antiporter protein; Region: 2A0121; TIGR00900 405534014210 putative substrate translocation pore; other site 405534014211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534014212 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405534014213 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405534014214 Domain of unknown function DUF87; Region: DUF87; pfam01935 405534014215 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405534014216 ABC transporter; Region: ABC_tran_2; pfam12848 405534014217 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405534014218 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405534014219 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405534014220 Coenzyme A binding pocket [chemical binding]; other site 405534014221 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 405534014222 Nuclease-related domain; Region: NERD; pfam08378 405534014223 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 405534014224 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405534014225 Walker A/P-loop; other site 405534014226 ATP binding site [chemical binding]; other site 405534014227 Q-loop/lid; other site 405534014228 ABC transporter signature motif; other site 405534014229 Walker B; other site 405534014230 D-loop; other site 405534014231 H-loop/switch region; other site 405534014232 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405534014233 ABC-ATPase subunit interface; other site 405534014234 dimer interface [polypeptide binding]; other site 405534014235 putative PBP binding regions; other site 405534014236 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405534014237 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405534014238 ABC-ATPase subunit interface; other site 405534014239 dimer interface [polypeptide binding]; other site 405534014240 putative PBP binding regions; other site 405534014241 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 405534014242 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 405534014243 putative ligand binding residues [chemical binding]; other site 405534014244 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534014245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534014246 active site 405534014247 phosphorylation site [posttranslational modification] 405534014248 intermolecular recognition site; other site 405534014249 dimerization interface [polypeptide binding]; other site 405534014250 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534014251 DNA binding site [nucleotide binding] 405534014252 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405534014253 FtsX-like permease family; Region: FtsX; pfam02687 405534014254 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405534014255 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405534014256 Walker A/P-loop; other site 405534014257 ATP binding site [chemical binding]; other site 405534014258 Q-loop/lid; other site 405534014259 ABC transporter signature motif; other site 405534014260 Walker B; other site 405534014261 D-loop; other site 405534014262 H-loop/switch region; other site 405534014263 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405534014264 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405534014265 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534014266 dimerization interface [polypeptide binding]; other site 405534014267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534014268 dimer interface [polypeptide binding]; other site 405534014269 phosphorylation site [posttranslational modification] 405534014270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534014271 ATP binding site [chemical binding]; other site 405534014272 Mg2+ binding site [ion binding]; other site 405534014273 G-X-G motif; other site 405534014274 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534014275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534014276 active site 405534014277 phosphorylation site [posttranslational modification] 405534014278 intermolecular recognition site; other site 405534014279 dimerization interface [polypeptide binding]; other site 405534014280 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534014281 DNA binding site [nucleotide binding] 405534014282 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405534014283 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 405534014284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534014285 S-adenosylmethionine binding site [chemical binding]; other site 405534014286 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 405534014287 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 405534014288 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405534014289 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405534014290 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 405534014291 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534014292 dimerization interface [polypeptide binding]; other site 405534014293 putative DNA binding site [nucleotide binding]; other site 405534014294 putative Zn2+ binding site [ion binding]; other site 405534014295 hypothetical protein; Validated; Region: PRK08223 405534014296 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 405534014297 ATP binding site [chemical binding]; other site 405534014298 substrate interface [chemical binding]; other site 405534014299 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 405534014300 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 405534014301 substrate binding site [chemical binding]; other site 405534014302 active site 405534014303 cosubstrate binding site; other site 405534014304 catalytic site [active] 405534014305 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cd08370 405534014306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534014307 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534014308 putative substrate translocation pore; other site 405534014309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534014310 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 405534014311 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 405534014312 tetramer interface [polypeptide binding]; other site 405534014313 active site 405534014314 Mg2+/Mn2+ binding site [ion binding]; other site 405534014315 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534014316 putative DNA binding site [nucleotide binding]; other site 405534014317 dimerization interface [polypeptide binding]; other site 405534014318 putative Zn2+ binding site [ion binding]; other site 405534014319 Protein of unknown function (DUF418); Region: DUF418; cl12135 405534014320 Protein of unknown function (DUF418); Region: DUF418; pfam04235 405534014321 CAAX protease self-immunity; Region: Abi; pfam02517 405534014322 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 405534014323 SmpB-tmRNA interface; other site 405534014324 ribonuclease R; Region: RNase_R; TIGR02063 405534014325 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 405534014326 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 405534014327 RNB domain; Region: RNB; pfam00773 405534014328 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 405534014329 RNA binding site [nucleotide binding]; other site 405534014330 Esterase/lipase [General function prediction only]; Region: COG1647 405534014331 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 405534014332 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 405534014333 holin-like protein; Validated; Region: PRK01658 405534014334 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 405534014335 active site 405534014336 enolase; Provisional; Region: eno; PRK00077 405534014337 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 405534014338 dimer interface [polypeptide binding]; other site 405534014339 metal binding site [ion binding]; metal-binding site 405534014340 substrate binding pocket [chemical binding]; other site 405534014341 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 405534014342 phosphoglyceromutase; Provisional; Region: PRK05434 405534014343 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 405534014344 triosephosphate isomerase; Provisional; Region: PRK14565 405534014345 substrate binding site [chemical binding]; other site 405534014346 dimer interface [polypeptide binding]; other site 405534014347 catalytic triad [active] 405534014348 Phosphoglycerate kinase; Region: PGK; pfam00162 405534014349 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 405534014350 substrate binding site [chemical binding]; other site 405534014351 hinge regions; other site 405534014352 ADP binding site [chemical binding]; other site 405534014353 catalytic site [active] 405534014354 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 405534014355 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 405534014356 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 405534014357 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 405534014358 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 405534014359 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 405534014360 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 405534014361 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 405534014362 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 405534014363 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 405534014364 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534014365 non-specific DNA binding site [nucleotide binding]; other site 405534014366 salt bridge; other site 405534014367 sequence-specific DNA binding site [nucleotide binding]; other site 405534014368 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405534014369 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 405534014370 catalytic residues [active] 405534014371 catalytic nucleophile [active] 405534014372 Presynaptic Site I dimer interface [polypeptide binding]; other site 405534014373 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 405534014374 Synaptic Flat tetramer interface [polypeptide binding]; other site 405534014375 Synaptic Site I dimer interface [polypeptide binding]; other site 405534014376 DNA binding site [nucleotide binding] 405534014377 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 405534014378 DNA-binding interface [nucleotide binding]; DNA binding site 405534014379 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 405534014380 DNA methylase; Region: N6_N4_Mtase; pfam01555 405534014381 DNA methylase; Region: N6_N4_Mtase; cl17433 405534014382 DEAD-like helicases superfamily; Region: DEXDc; smart00487 405534014383 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 405534014384 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405534014385 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 405534014386 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405534014387 active site 405534014388 DNA binding site [nucleotide binding] 405534014389 Int/Topo IB signature motif; other site 405534014390 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 405534014391 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 405534014392 stage V sporulation protein AD; Provisional; Region: PRK12404 405534014393 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 405534014394 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 405534014395 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 405534014396 Predicted membrane protein [Function unknown]; Region: COG2323 405534014397 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 405534014398 Clp protease; Region: CLP_protease; pfam00574 405534014399 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 405534014400 oligomer interface [polypeptide binding]; other site 405534014401 active site residues [active] 405534014402 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 405534014403 dimerization domain swap beta strand [polypeptide binding]; other site 405534014404 regulatory protein interface [polypeptide binding]; other site 405534014405 active site 405534014406 regulatory phosphorylation site [posttranslational modification]; other site 405534014407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 405534014408 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 405534014409 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 405534014410 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 405534014411 phosphate binding site [ion binding]; other site 405534014412 putative substrate binding pocket [chemical binding]; other site 405534014413 dimer interface [polypeptide binding]; other site 405534014414 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 405534014415 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 405534014416 putative active site [active] 405534014417 nucleotide binding site [chemical binding]; other site 405534014418 nudix motif; other site 405534014419 putative metal binding site [ion binding]; other site 405534014420 Domain of unknown function (DUF368); Region: DUF368; pfam04018 405534014421 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 405534014422 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405534014423 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405534014424 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405534014425 binding surface 405534014426 TPR motif; other site 405534014427 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405534014428 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405534014429 binding surface 405534014430 Tetratricopeptide repeat; Region: TPR_16; pfam13432 405534014431 TPR motif; other site 405534014432 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 405534014433 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 405534014434 trimer interface [polypeptide binding]; other site 405534014435 active site 405534014436 substrate binding site [chemical binding]; other site 405534014437 CoA binding site [chemical binding]; other site 405534014438 pyrophosphatase PpaX; Provisional; Region: PRK13288 405534014439 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534014440 active site 405534014441 motif I; other site 405534014442 motif II; other site 405534014443 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 405534014444 HPr kinase/phosphorylase; Provisional; Region: PRK05428 405534014445 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 405534014446 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 405534014447 Hpr binding site; other site 405534014448 active site 405534014449 homohexamer subunit interaction site [polypeptide binding]; other site 405534014450 Predicted membrane protein [Function unknown]; Region: COG1950 405534014451 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 405534014452 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 405534014453 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 405534014454 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 405534014455 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 405534014456 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 405534014457 excinuclease ABC subunit B; Provisional; Region: PRK05298 405534014458 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405534014459 ATP binding site [chemical binding]; other site 405534014460 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405534014461 nucleotide binding region [chemical binding]; other site 405534014462 ATP-binding site [chemical binding]; other site 405534014463 Ultra-violet resistance protein B; Region: UvrB; pfam12344 405534014464 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 405534014465 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405534014466 DNA binding residues [nucleotide binding] 405534014467 dimer interface [polypeptide binding]; other site 405534014468 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 405534014469 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405534014470 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534014471 non-specific DNA binding site [nucleotide binding]; other site 405534014472 salt bridge; other site 405534014473 sequence-specific DNA binding site [nucleotide binding]; other site 405534014474 Predicted membrane protein [Function unknown]; Region: COG2855 405534014475 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405534014476 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405534014477 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 405534014478 putative dimerization interface [polypeptide binding]; other site 405534014479 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 405534014480 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405534014481 DNA binding residues [nucleotide binding] 405534014482 putative dimer interface [polypeptide binding]; other site 405534014483 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 405534014484 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405534014485 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405534014486 hypothetical protein; Provisional; Region: PRK12855 405534014487 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405534014488 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405534014489 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 405534014490 Walker A/P-loop; other site 405534014491 ATP binding site [chemical binding]; other site 405534014492 Q-loop/lid; other site 405534014493 ABC transporter signature motif; other site 405534014494 Walker B; other site 405534014495 D-loop; other site 405534014496 H-loop/switch region; other site 405534014497 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 405534014498 protein binding site [polypeptide binding]; other site 405534014499 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 405534014500 C-terminal peptidase (prc); Region: prc; TIGR00225 405534014501 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 405534014502 protein binding site [polypeptide binding]; other site 405534014503 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 405534014504 Catalytic dyad [active] 405534014505 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 405534014506 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 405534014507 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 405534014508 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534014509 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 405534014510 Walker A/P-loop; other site 405534014511 ATP binding site [chemical binding]; other site 405534014512 Q-loop/lid; other site 405534014513 ABC transporter signature motif; other site 405534014514 Walker B; other site 405534014515 D-loop; other site 405534014516 H-loop/switch region; other site 405534014517 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 405534014518 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 405534014519 peptide chain release factor 2; Provisional; Region: PRK06746 405534014520 This domain is found in peptide chain release factors; Region: PCRF; smart00937 405534014521 RF-1 domain; Region: RF-1; pfam00472 405534014522 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 405534014523 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 405534014524 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 405534014525 nucleotide binding region [chemical binding]; other site 405534014526 ATP-binding site [chemical binding]; other site 405534014527 SEC-C motif; Region: SEC-C; pfam02810 405534014528 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 405534014529 30S subunit binding site; other site 405534014530 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405534014531 DNA-binding site [nucleotide binding]; DNA binding site 405534014532 RNA-binding motif; other site 405534014533 comF family protein; Region: comF; TIGR00201 405534014534 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405534014535 active site 405534014536 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 405534014537 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405534014538 ATP binding site [chemical binding]; other site 405534014539 putative Mg++ binding site [ion binding]; other site 405534014540 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405534014541 nucleotide binding region [chemical binding]; other site 405534014542 ATP-binding site [chemical binding]; other site 405534014543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 405534014544 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405534014545 NlpC/P60 family; Region: NLPC_P60; pfam00877 405534014546 Predicted transcriptional regulators [Transcription]; Region: COG1733 405534014547 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405534014548 dimerization interface [polypeptide binding]; other site 405534014549 putative DNA binding site [nucleotide binding]; other site 405534014550 putative Zn2+ binding site [ion binding]; other site 405534014551 EDD domain protein, DegV family; Region: DegV; TIGR00762 405534014552 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 405534014553 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 405534014554 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 405534014555 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 405534014556 Transcriptional regulator [Transcription]; Region: LytR; COG1316 405534014557 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 405534014558 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 405534014559 active site 405534014560 homodimer interface [polypeptide binding]; other site 405534014561 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 405534014562 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 405534014563 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 405534014564 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 405534014565 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 405534014566 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 405534014567 Mg++ binding site [ion binding]; other site 405534014568 putative catalytic motif [active] 405534014569 substrate binding site [chemical binding]; other site 405534014570 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405534014571 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 405534014572 NodB motif; other site 405534014573 active site 405534014574 catalytic site [active] 405534014575 Zn binding site [ion binding]; other site 405534014576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405534014577 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 405534014578 Walker A motif; other site 405534014579 ATP binding site [chemical binding]; other site 405534014580 Walker B motif; other site 405534014581 arginine finger; other site 405534014582 Transcriptional antiterminator [Transcription]; Region: COG3933 405534014583 PRD domain; Region: PRD; pfam00874 405534014584 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 405534014585 active pocket/dimerization site; other site 405534014586 active site 405534014587 phosphorylation site [posttranslational modification] 405534014588 PRD domain; Region: PRD; pfam00874 405534014589 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 405534014590 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 405534014591 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 405534014592 Chromate transporter; Region: Chromate_transp; pfam02417 405534014593 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 405534014594 putative active site [active] 405534014595 YdjC motif; other site 405534014596 Mg binding site [ion binding]; other site 405534014597 putative homodimer interface [polypeptide binding]; other site 405534014598 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 405534014599 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 405534014600 NAD binding site [chemical binding]; other site 405534014601 sugar binding site [chemical binding]; other site 405534014602 divalent metal binding site [ion binding]; other site 405534014603 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405534014604 dimer interface [polypeptide binding]; other site 405534014605 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 405534014606 active site 405534014607 methionine cluster; other site 405534014608 phosphorylation site [posttranslational modification] 405534014609 metal binding site [ion binding]; metal-binding site 405534014610 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 405534014611 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 405534014612 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 405534014613 active site 405534014614 P-loop; other site 405534014615 phosphorylation site [posttranslational modification] 405534014616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534014617 S-adenosylmethionine binding site [chemical binding]; other site 405534014618 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 405534014619 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 405534014620 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 405534014621 LytTr DNA-binding domain; Region: LytTR; smart00850 405534014622 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 405534014623 methionine cluster; other site 405534014624 active site 405534014625 phosphorylation site [posttranslational modification] 405534014626 metal binding site [ion binding]; metal-binding site 405534014627 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 405534014628 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 405534014629 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 405534014630 active site 405534014631 P-loop; other site 405534014632 phosphorylation site [posttranslational modification] 405534014633 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 405534014634 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405534014635 Acyltransferase family; Region: Acyl_transf_3; pfam01757 405534014636 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 405534014637 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405534014638 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 405534014639 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 405534014640 active site 405534014641 catalytic site [active] 405534014642 Cna protein B-type domain; Region: Cna_B; pfam05738 405534014643 Cna protein B-type domain; Region: Cna_B; pfam05738 405534014644 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405534014645 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 405534014646 Domain of unknown function DUF11; Region: DUF11; pfam01345 405534014647 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405534014648 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405534014649 Domain of unknown function DUF11; Region: DUF11; cl17728 405534014650 Cna protein B-type domain; Region: Cna_B; pfam05738 405534014651 Predicted membrane protein [Function unknown]; Region: COG1511 405534014652 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 405534014653 Predicted membrane protein [Function unknown]; Region: COG1511 405534014654 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 405534014655 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405534014656 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405534014657 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 405534014658 putative dimerization interface [polypeptide binding]; other site 405534014659 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 405534014660 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 405534014661 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 405534014662 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 405534014663 transmembrane helices; other site 405534014664 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 405534014665 ThiC-associated domain; Region: ThiC-associated; pfam13667 405534014666 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 405534014667 L-lactate permease; Region: Lactate_perm; cl00701 405534014668 glycolate transporter; Provisional; Region: PRK09695 405534014669 Tic20-like protein; Region: Tic20; pfam09685 405534014670 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 405534014671 Uncharacterized conserved protein [Function unknown]; Region: COG3339 405534014672 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 405534014673 Sulfatase; Region: Sulfatase; pfam00884 405534014674 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 405534014675 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 405534014676 homodimer interface [polypeptide binding]; other site 405534014677 substrate-cofactor binding pocket; other site 405534014678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534014679 catalytic residue [active] 405534014680 Bacterial SH3 domain; Region: SH3_3; pfam08239 405534014681 Bacterial SH3 domain; Region: SH3_3; pfam08239 405534014682 Bacterial SH3 domain; Region: SH3_3; pfam08239 405534014683 Bacterial SH3 domain; Region: SH3_3; pfam08239 405534014684 Bacterial SH3 domain; Region: SH3_3; pfam08239 405534014685 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405534014686 NlpC/P60 family; Region: NLPC_P60; pfam00877 405534014687 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405534014688 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405534014689 Nucleoside recognition; Region: Gate; pfam07670 405534014690 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405534014691 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 405534014692 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 405534014693 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 405534014694 DXD motif; other site 405534014695 BCCT family transporter; Region: BCCT; pfam02028 405534014696 Bacterial SH3 domain; Region: SH3_3; pfam08239 405534014697 Bacterial SH3 domain; Region: SH3_3; pfam08239 405534014698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 405534014699 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 405534014700 Predicted membrane protein [Function unknown]; Region: COG4640 405534014701 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 405534014702 Double zinc ribbon; Region: DZR; pfam12773 405534014703 Double zinc ribbon; Region: DZR; pfam12773 405534014704 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 405534014705 SNF2 Helicase protein; Region: DUF3670; pfam12419 405534014706 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 405534014707 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405534014708 ATP binding site [chemical binding]; other site 405534014709 putative Mg++ binding site [ion binding]; other site 405534014710 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 405534014711 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405534014712 nucleotide binding region [chemical binding]; other site 405534014713 ATP-binding site [chemical binding]; other site 405534014714 Predicted integral membrane protein [Function unknown]; Region: COG5652 405534014715 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 405534014716 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 405534014717 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 405534014718 ComK protein; Region: ComK; pfam06338 405534014719 RNA polymerase factor sigma-70; Validated; Region: PRK06759 405534014720 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405534014721 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405534014722 DNA binding residues [nucleotide binding] 405534014723 Yip1 domain; Region: Yip1; cl17815 405534014724 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 405534014725 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405534014726 FtsX-like permease family; Region: FtsX; pfam02687 405534014727 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405534014728 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405534014729 Walker A/P-loop; other site 405534014730 ATP binding site [chemical binding]; other site 405534014731 Q-loop/lid; other site 405534014732 ABC transporter signature motif; other site 405534014733 Walker B; other site 405534014734 D-loop; other site 405534014735 H-loop/switch region; other site 405534014736 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 405534014737 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 405534014738 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 405534014739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534014740 putative substrate translocation pore; other site 405534014741 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 405534014742 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 405534014743 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 405534014744 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 405534014745 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534014746 dimerization interface [polypeptide binding]; other site 405534014747 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534014748 dimer interface [polypeptide binding]; other site 405534014749 phosphorylation site [posttranslational modification] 405534014750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534014751 ATP binding site [chemical binding]; other site 405534014752 Mg2+ binding site [ion binding]; other site 405534014753 G-X-G motif; other site 405534014754 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534014755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534014756 active site 405534014757 phosphorylation site [posttranslational modification] 405534014758 intermolecular recognition site; other site 405534014759 dimerization interface [polypeptide binding]; other site 405534014760 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534014761 DNA binding site [nucleotide binding] 405534014762 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 405534014763 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 405534014764 NAD binding site [chemical binding]; other site 405534014765 homodimer interface [polypeptide binding]; other site 405534014766 active site 405534014767 substrate binding site [chemical binding]; other site 405534014768 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 405534014769 catalytic triad [active] 405534014770 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 405534014771 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 405534014772 UDP-glucose 4-epimerase; Region: PLN02240 405534014773 NAD binding site [chemical binding]; other site 405534014774 homodimer interface [polypeptide binding]; other site 405534014775 active site 405534014776 substrate binding site [chemical binding]; other site 405534014777 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 405534014778 active site 405534014779 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 405534014780 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405534014781 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 405534014782 putative ADP-binding pocket [chemical binding]; other site 405534014783 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 405534014784 putative glycosyl transferase; Provisional; Region: PRK10125 405534014785 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 405534014786 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 405534014787 active site 405534014788 homodimer interface [polypeptide binding]; other site 405534014789 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 405534014790 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 405534014791 putative NAD(P) binding site [chemical binding]; other site 405534014792 active site 405534014793 putative substrate binding site [chemical binding]; other site 405534014794 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 405534014795 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 405534014796 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 405534014797 NAD(P) binding site [chemical binding]; other site 405534014798 homodimer interface [polypeptide binding]; other site 405534014799 substrate binding site [chemical binding]; other site 405534014800 active site 405534014801 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 405534014802 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405534014803 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 405534014804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405534014805 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 405534014806 NAD(P) binding site [chemical binding]; other site 405534014807 active site 405534014808 Bacterial sugar transferase; Region: Bac_transf; pfam02397 405534014809 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 405534014810 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 405534014811 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 405534014812 NAD(P) binding site [chemical binding]; other site 405534014813 homodimer interface [polypeptide binding]; other site 405534014814 substrate binding site [chemical binding]; other site 405534014815 active site 405534014816 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 405534014817 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 405534014818 active site 405534014819 tetramer interface; other site 405534014820 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 405534014821 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 405534014822 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 405534014823 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 405534014824 Chain length determinant protein; Region: Wzz; cl15801 405534014825 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 405534014826 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 405534014827 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 405534014828 rod shape-determining protein Mbl; Provisional; Region: PRK13928 405534014829 MreB and similar proteins; Region: MreB_like; cd10225 405534014830 nucleotide binding site [chemical binding]; other site 405534014831 Mg binding site [ion binding]; other site 405534014832 putative protofilament interaction site [polypeptide binding]; other site 405534014833 RodZ interaction site [polypeptide binding]; other site 405534014834 Stage III sporulation protein D; Region: SpoIIID; cl17560 405534014835 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405534014836 Peptidase family M23; Region: Peptidase_M23; pfam01551 405534014837 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 405534014838 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 405534014839 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405534014840 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405534014841 Walker A/P-loop; other site 405534014842 ATP binding site [chemical binding]; other site 405534014843 Q-loop/lid; other site 405534014844 ABC transporter signature motif; other site 405534014845 Walker B; other site 405534014846 D-loop; other site 405534014847 H-loop/switch region; other site 405534014848 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405534014849 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405534014850 Walker A/P-loop; other site 405534014851 ATP binding site [chemical binding]; other site 405534014852 Q-loop/lid; other site 405534014853 ABC transporter signature motif; other site 405534014854 Walker B; other site 405534014855 D-loop; other site 405534014856 H-loop/switch region; other site 405534014857 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 405534014858 LytTr DNA-binding domain; Region: LytTR; pfam04397 405534014859 Stage II sporulation protein; Region: SpoIID; pfam08486 405534014860 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 405534014861 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 405534014862 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 405534014863 hinge; other site 405534014864 active site 405534014865 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 405534014866 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 405534014867 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 405534014868 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 405534014869 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 405534014870 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 405534014871 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 405534014872 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 405534014873 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 405534014874 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 405534014875 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 405534014876 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 405534014877 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 405534014878 4Fe-4S binding domain; Region: Fer4; cl02805 405534014879 4Fe-4S binding domain; Region: Fer4; pfam00037 405534014880 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 405534014881 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 405534014882 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 405534014883 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 405534014884 NADH dehydrogenase subunit C; Validated; Region: PRK07735 405534014885 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 405534014886 NADH dehydrogenase subunit B; Validated; Region: PRK06411 405534014887 NADH dehydrogenase subunit A; Validated; Region: PRK07756 405534014888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405534014889 PAS domain; Region: PAS_9; pfam13426 405534014890 putative active site [active] 405534014891 heme pocket [chemical binding]; other site 405534014892 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405534014893 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405534014894 metal binding site [ion binding]; metal-binding site 405534014895 active site 405534014896 I-site; other site 405534014897 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405534014898 Protein of unknown function (DUF975); Region: DUF975; cl10504 405534014899 Protein of unknown function (DUF975); Region: DUF975; cl10504 405534014900 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 405534014901 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 405534014902 gamma subunit interface [polypeptide binding]; other site 405534014903 epsilon subunit interface [polypeptide binding]; other site 405534014904 LBP interface [polypeptide binding]; other site 405534014905 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 405534014906 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 405534014907 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 405534014908 alpha subunit interaction interface [polypeptide binding]; other site 405534014909 Walker A motif; other site 405534014910 ATP binding site [chemical binding]; other site 405534014911 Walker B motif; other site 405534014912 inhibitor binding site; inhibition site 405534014913 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 405534014914 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 405534014915 core domain interface [polypeptide binding]; other site 405534014916 delta subunit interface [polypeptide binding]; other site 405534014917 epsilon subunit interface [polypeptide binding]; other site 405534014918 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 405534014919 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 405534014920 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 405534014921 beta subunit interaction interface [polypeptide binding]; other site 405534014922 Walker A motif; other site 405534014923 ATP binding site [chemical binding]; other site 405534014924 Walker B motif; other site 405534014925 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 405534014926 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 405534014927 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 405534014928 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 405534014929 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 405534014930 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 405534014931 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 405534014932 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 405534014933 ATP synthase I chain; Region: ATP_synt_I; pfam03899 405534014934 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 405534014935 Protein of unknown function (DUF4024); Region: DUF4024; pfam13216 405534014936 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405534014937 active site 405534014938 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 405534014939 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 405534014940 dimer interface [polypeptide binding]; other site 405534014941 active site 405534014942 glycine-pyridoxal phosphate binding site [chemical binding]; other site 405534014943 folate binding site [chemical binding]; other site 405534014944 hypothetical protein; Provisional; Region: PRK13690 405534014945 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 405534014946 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 405534014947 Low molecular weight phosphatase family; Region: LMWPc; cd00115 405534014948 active site 405534014949 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 405534014950 HPr interaction site; other site 405534014951 glycerol kinase (GK) interaction site [polypeptide binding]; other site 405534014952 active site 405534014953 phosphorylation site [posttranslational modification] 405534014954 Predicted membrane protein [Function unknown]; Region: COG2259 405534014955 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 405534014956 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 405534014957 Predicted membrane protein [Function unknown]; Region: COG1971 405534014958 Domain of unknown function DUF; Region: DUF204; pfam02659 405534014959 Domain of unknown function DUF; Region: DUF204; pfam02659 405534014960 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 405534014961 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 405534014962 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405534014963 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 405534014964 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 405534014965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534014966 S-adenosylmethionine binding site [chemical binding]; other site 405534014967 peptide chain release factor 1; Validated; Region: prfA; PRK00591 405534014968 This domain is found in peptide chain release factors; Region: PCRF; smart00937 405534014969 RF-1 domain; Region: RF-1; pfam00472 405534014970 thymidine kinase; Provisional; Region: PRK04296 405534014971 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 405534014972 transcription termination factor Rho; Provisional; Region: rho; PRK09376 405534014973 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 405534014974 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 405534014975 RNA binding site [nucleotide binding]; other site 405534014976 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 405534014977 multimer interface [polypeptide binding]; other site 405534014978 Walker A motif; other site 405534014979 ATP binding site [chemical binding]; other site 405534014980 Walker B motif; other site 405534014981 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 405534014982 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 405534014983 putative active site [active] 405534014984 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 405534014985 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 405534014986 hinge; other site 405534014987 active site 405534014988 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 405534014989 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 405534014990 intersubunit interface [polypeptide binding]; other site 405534014991 active site 405534014992 zinc binding site [ion binding]; other site 405534014993 Na+ binding site [ion binding]; other site 405534014994 Response regulator receiver domain; Region: Response_reg; pfam00072 405534014995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534014996 active site 405534014997 phosphorylation site [posttranslational modification] 405534014998 intermolecular recognition site; other site 405534014999 dimerization interface [polypeptide binding]; other site 405534015000 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 405534015001 CTP synthetase; Validated; Region: pyrG; PRK05380 405534015002 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 405534015003 Catalytic site [active] 405534015004 active site 405534015005 UTP binding site [chemical binding]; other site 405534015006 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 405534015007 active site 405534015008 putative oxyanion hole; other site 405534015009 catalytic triad [active] 405534015010 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 405534015011 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534015012 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534015013 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405534015014 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 405534015015 FAD binding site [chemical binding]; other site 405534015016 homotetramer interface [polypeptide binding]; other site 405534015017 substrate binding pocket [chemical binding]; other site 405534015018 catalytic base [active] 405534015019 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405534015020 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 405534015021 FAD binding site [chemical binding]; other site 405534015022 homotetramer interface [polypeptide binding]; other site 405534015023 substrate binding pocket [chemical binding]; other site 405534015024 catalytic base [active] 405534015025 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 405534015026 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 405534015027 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 405534015028 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 405534015029 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 405534015030 dimer interface [polypeptide binding]; other site 405534015031 active site 405534015032 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 405534015033 4Fe-4S binding domain; Region: Fer4; cl02805 405534015034 Cysteine-rich domain; Region: CCG; pfam02754 405534015035 Cysteine-rich domain; Region: CCG; pfam02754 405534015036 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405534015037 PLD-like domain; Region: PLDc_2; pfam13091 405534015038 putative active site [active] 405534015039 catalytic site [active] 405534015040 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 405534015041 PLD-like domain; Region: PLDc_2; pfam13091 405534015042 putative active site [active] 405534015043 catalytic site [active] 405534015044 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 405534015045 PAS domain S-box; Region: sensory_box; TIGR00229 405534015046 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405534015047 putative active site [active] 405534015048 heme pocket [chemical binding]; other site 405534015049 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405534015050 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405534015051 metal binding site [ion binding]; metal-binding site 405534015052 active site 405534015053 I-site; other site 405534015054 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405534015055 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 405534015056 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405534015057 non-specific DNA binding site [nucleotide binding]; other site 405534015058 salt bridge; other site 405534015059 sequence-specific DNA binding site [nucleotide binding]; other site 405534015060 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405534015061 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405534015062 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405534015063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534015064 active site 405534015065 phosphorylation site [posttranslational modification] 405534015066 intermolecular recognition site; other site 405534015067 dimerization interface [polypeptide binding]; other site 405534015068 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405534015069 DNA binding residues [nucleotide binding] 405534015070 dimerization interface [polypeptide binding]; other site 405534015071 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405534015072 Histidine kinase; Region: HisKA_3; pfam07730 405534015073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534015074 ATP binding site [chemical binding]; other site 405534015075 Mg2+ binding site [ion binding]; other site 405534015076 G-X-G motif; other site 405534015077 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 405534015078 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 405534015079 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405534015080 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405534015081 Walker A/P-loop; other site 405534015082 ATP binding site [chemical binding]; other site 405534015083 Q-loop/lid; other site 405534015084 ABC transporter signature motif; other site 405534015085 Walker B; other site 405534015086 D-loop; other site 405534015087 H-loop/switch region; other site 405534015088 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 405534015089 active site 405534015090 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 405534015091 Proacrosin binding protein sp32; Region: PBP_sp32; pfam07222 405534015092 Collagen binding domain; Region: Collagen_bind; pfam05737 405534015093 Collagen binding domain; Region: Collagen_bind; pfam05737 405534015094 Collagen binding domain; Region: Collagen_bind; pfam05737 405534015095 Cna protein B-type domain; Region: Cna_B; pfam05738 405534015096 Cna protein B-type domain; Region: Cna_B; pfam05738 405534015097 Cna protein B-type domain; Region: Cna_B; pfam05738 405534015098 Cna protein B-type domain; Region: Cna_B; pfam05738 405534015099 Cna protein B-type domain; Region: Cna_B; pfam05738 405534015100 Cna protein B-type domain; Region: Cna_B; pfam05738 405534015101 Cna protein B-type domain; Region: Cna_B; pfam05738 405534015102 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 405534015103 Cna protein B-type domain; Region: Cna_B; pfam05738 405534015104 Cna protein B-type domain; Region: Cna_B; pfam05738 405534015105 Cna protein B-type domain; Region: Cna_B; pfam05738 405534015106 Cna protein B-type domain; Region: Cna_B; pfam05738 405534015107 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 405534015108 Cna protein B-type domain; Region: Cna_B; pfam05738 405534015109 Cna protein B-type domain; Region: Cna_B; pfam05738 405534015110 Cna protein B-type domain; Region: Cna_B; pfam05738 405534015111 Cna protein B-type domain; Region: Cna_B; pfam05738 405534015112 Cna protein B-type domain; Region: Cna_B; pfam05738 405534015113 Cna protein B-type domain; Region: Cna_B; pfam05738 405534015114 Cna protein B-type domain; Region: Cna_B; pfam05738 405534015115 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 405534015116 Cna protein B-type domain; Region: Cna_B; pfam05738 405534015117 Cna protein B-type domain; Region: Cna_B; pfam05738 405534015118 Cna protein B-type domain; Region: Cna_B; pfam05738 405534015119 Cna protein B-type domain; Region: Cna_B; pfam05738 405534015120 Cna protein B-type domain; Region: Cna_B; pfam05738 405534015121 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 405534015122 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 405534015123 PA/protease or protease-like domain interface [polypeptide binding]; other site 405534015124 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 405534015125 Peptidase family M28; Region: Peptidase_M28; pfam04389 405534015126 metal binding site [ion binding]; metal-binding site 405534015127 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 405534015128 RNA polymerase sigma factor; Provisional; Region: PRK12522 405534015129 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405534015130 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405534015131 DNA binding residues [nucleotide binding] 405534015132 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 405534015133 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 405534015134 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 405534015135 active site 405534015136 HIGH motif; other site 405534015137 KMSK motif region; other site 405534015138 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 405534015139 tRNA binding surface [nucleotide binding]; other site 405534015140 anticodon binding site; other site 405534015141 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 405534015142 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 405534015143 putative dimer interface [polypeptide binding]; other site 405534015144 catalytic triad [active] 405534015145 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405534015146 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 405534015147 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 405534015148 agmatinase; Region: agmatinase; TIGR01230 405534015149 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 405534015150 putative active site [active] 405534015151 Mn binding site [ion binding]; other site 405534015152 spermidine synthase; Provisional; Region: PRK00811 405534015153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534015154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534015155 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405534015156 putative substrate translocation pore; other site 405534015157 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405534015158 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 405534015159 DNA binding residues [nucleotide binding] 405534015160 putative dimer interface [polypeptide binding]; other site 405534015161 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 405534015162 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 405534015163 active site 405534015164 catalytic site [active] 405534015165 metal binding site [ion binding]; metal-binding site 405534015166 dimer interface [polypeptide binding]; other site 405534015167 Transglycosylase; Region: Transgly; pfam00912 405534015168 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 405534015169 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405534015170 YwhD family; Region: YwhD; pfam08741 405534015171 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 405534015172 Peptidase family M50; Region: Peptidase_M50; pfam02163 405534015173 active site 405534015174 putative substrate binding region [chemical binding]; other site 405534015175 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 405534015176 active site 1 [active] 405534015177 dimer interface [polypeptide binding]; other site 405534015178 hexamer interface [polypeptide binding]; other site 405534015179 active site 2 [active] 405534015180 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 405534015181 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405534015182 Zn2+ binding site [ion binding]; other site 405534015183 Mg2+ binding site [ion binding]; other site 405534015184 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405534015185 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 405534015186 intersubunit interface [polypeptide binding]; other site 405534015187 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405534015188 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405534015189 Walker A/P-loop; other site 405534015190 ATP binding site [chemical binding]; other site 405534015191 Q-loop/lid; other site 405534015192 ABC transporter signature motif; other site 405534015193 Walker B; other site 405534015194 D-loop; other site 405534015195 H-loop/switch region; other site 405534015196 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405534015197 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405534015198 ABC-ATPase subunit interface; other site 405534015199 dimer interface [polypeptide binding]; other site 405534015200 putative PBP binding regions; other site 405534015201 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405534015202 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405534015203 ABC-ATPase subunit interface; other site 405534015204 dimer interface [polypeptide binding]; other site 405534015205 putative PBP binding regions; other site 405534015206 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 405534015207 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 405534015208 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 405534015209 hypothetical protein; Provisional; Region: PRK12473 405534015210 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 405534015211 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 405534015212 putative heme peroxidase; Provisional; Region: PRK12276 405534015213 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 405534015214 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405534015215 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 405534015216 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 405534015217 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 405534015218 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 405534015219 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 405534015220 Ion channel; Region: Ion_trans_2; pfam07885 405534015221 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 405534015222 TrkA-N domain; Region: TrkA_N; pfam02254 405534015223 TrkA-C domain; Region: TrkA_C; pfam02080 405534015224 putative uracil/xanthine transporter; Provisional; Region: PRK11412 405534015225 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405534015226 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534015227 motif II; other site 405534015228 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534015229 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 405534015230 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 405534015231 ligand binding site [chemical binding]; other site 405534015232 active site 405534015233 UGI interface [polypeptide binding]; other site 405534015234 catalytic site [active] 405534015235 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 405534015236 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 405534015237 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405534015238 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405534015239 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 405534015240 Walker A/P-loop; other site 405534015241 ATP binding site [chemical binding]; other site 405534015242 Q-loop/lid; other site 405534015243 ABC transporter signature motif; other site 405534015244 Walker B; other site 405534015245 D-loop; other site 405534015246 H-loop/switch region; other site 405534015247 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 405534015248 active site 405534015249 catalytic triad [active] 405534015250 oxyanion hole [active] 405534015251 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405534015252 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405534015253 DNA binding site [nucleotide binding] 405534015254 domain linker motif; other site 405534015255 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 405534015256 putative dimerization interface [polypeptide binding]; other site 405534015257 putative ligand binding site [chemical binding]; other site 405534015258 Predicted membrane protein [Function unknown]; Region: COG2364 405534015259 homoserine dehydrogenase; Provisional; Region: PRK06349 405534015260 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 405534015261 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 405534015262 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 405534015263 homoserine O-succinyltransferase; Provisional; Region: PRK05368 405534015264 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 405534015265 proposed active site lysine [active] 405534015266 conserved cys residue [active] 405534015267 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 405534015268 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 405534015269 homodimer interface [polypeptide binding]; other site 405534015270 substrate-cofactor binding pocket; other site 405534015271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405534015272 catalytic residue [active] 405534015273 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 405534015274 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 405534015275 Cl- selectivity filter; other site 405534015276 Cl- binding residues [ion binding]; other site 405534015277 pore gating glutamate residue; other site 405534015278 dimer interface [polypeptide binding]; other site 405534015279 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 405534015280 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405534015281 active site 405534015282 motif I; other site 405534015283 motif II; other site 405534015284 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 405534015285 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405534015286 ligand binding site [chemical binding]; other site 405534015287 flexible hinge region; other site 405534015288 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 405534015289 azoreductase; Provisional; Region: PRK13556 405534015290 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405534015291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534015292 active site 405534015293 phosphorylation site [posttranslational modification] 405534015294 intermolecular recognition site; other site 405534015295 dimerization interface [polypeptide binding]; other site 405534015296 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405534015297 DNA binding residues [nucleotide binding] 405534015298 dimerization interface [polypeptide binding]; other site 405534015299 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 405534015300 GAF domain; Region: GAF; pfam01590 405534015301 GAF domain; Region: GAF_3; pfam13492 405534015302 GAF domain; Region: GAF_2; pfam13185 405534015303 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405534015304 Histidine kinase; Region: HisKA_3; pfam07730 405534015305 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 405534015306 ATP binding site [chemical binding]; other site 405534015307 Mg2+ binding site [ion binding]; other site 405534015308 G-X-G motif; other site 405534015309 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 405534015310 dimer interface [polypeptide binding]; other site 405534015311 substrate binding site [chemical binding]; other site 405534015312 ATP binding site [chemical binding]; other site 405534015313 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 405534015314 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405534015315 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405534015316 metal binding site [ion binding]; metal-binding site 405534015317 active site 405534015318 I-site; other site 405534015319 Protein of unknown function (DUF466); Region: DUF466; pfam04328 405534015320 carbon starvation protein A; Provisional; Region: PRK15015 405534015321 Carbon starvation protein CstA; Region: CstA; pfam02554 405534015322 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 405534015323 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 405534015324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534015325 active site 405534015326 phosphorylation site [posttranslational modification] 405534015327 intermolecular recognition site; other site 405534015328 dimerization interface [polypeptide binding]; other site 405534015329 LytTr DNA-binding domain; Region: LytTR; pfam04397 405534015330 benzoate transport; Region: 2A0115; TIGR00895 405534015331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534015332 putative substrate translocation pore; other site 405534015333 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 405534015334 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 405534015335 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405534015336 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 405534015337 Predicted membrane protein [Function unknown]; Region: COG2860 405534015338 UPF0126 domain; Region: UPF0126; pfam03458 405534015339 UPF0126 domain; Region: UPF0126; pfam03458 405534015340 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 405534015341 heme-binding site [chemical binding]; other site 405534015342 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405534015343 dimer interface [polypeptide binding]; other site 405534015344 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 405534015345 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 405534015346 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405534015347 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 405534015348 Ligand binding site; other site 405534015349 Putative Catalytic site; other site 405534015350 DXD motif; other site 405534015351 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 405534015352 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405534015353 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 405534015354 active site 405534015355 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 405534015356 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 405534015357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405534015358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405534015359 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405534015360 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405534015361 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405534015362 ABC transporter; Region: ABC_tran_2; pfam12848 405534015363 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405534015364 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405534015365 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405534015366 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 405534015367 Protein export membrane protein; Region: SecD_SecF; cl14618 405534015368 methionine sulfoxide reductase A; Provisional; Region: PRK14054 405534015369 methionine sulfoxide reductase B; Provisional; Region: PRK00222 405534015370 SelR domain; Region: SelR; pfam01641 405534015371 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 405534015372 antiholin-like protein LrgB; Provisional; Region: PRK04288 405534015373 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 405534015374 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 405534015375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534015376 active site 405534015377 phosphorylation site [posttranslational modification] 405534015378 intermolecular recognition site; other site 405534015379 dimerization interface [polypeptide binding]; other site 405534015380 LytTr DNA-binding domain; Region: LytTR; pfam04397 405534015381 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 405534015382 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 405534015383 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 405534015384 Histidine kinase; Region: His_kinase; pfam06580 405534015385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534015386 ATP binding site [chemical binding]; other site 405534015387 Mg2+ binding site [ion binding]; other site 405534015388 G-X-G motif; other site 405534015389 PyrR binding site 405534015390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405534015391 benzoate transport; Region: 2A0115; TIGR00895 405534015392 putative substrate translocation pore; other site 405534015393 BCCT family transporter; Region: BCCT; pfam02028 405534015394 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cl00254 405534015395 active site 405534015396 dimer interface [polypeptide binding]; other site 405534015397 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 405534015398 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 405534015399 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 405534015400 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405534015401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405534015402 NAD(P) binding site [chemical binding]; other site 405534015403 active site 405534015404 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 405534015405 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 405534015406 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 405534015407 GAF domain; Region: GAF_3; pfam13492 405534015408 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405534015409 binding surface 405534015410 TPR motif; other site 405534015411 Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960 405534015412 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924 405534015413 NodB motif; other site 405534015414 putative active site [active] 405534015415 putative catalytic site [active] 405534015416 putative Zn binding site [ion binding]; other site 405534015417 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 405534015418 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405534015419 Predicted membrane protein [Function unknown]; Region: COG4267 405534015420 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 405534015421 UDP-glucose 4-epimerase; Region: PLN02240 405534015422 NAD binding site [chemical binding]; other site 405534015423 homodimer interface [polypeptide binding]; other site 405534015424 active site 405534015425 substrate binding site [chemical binding]; other site 405534015426 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 405534015427 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 405534015428 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 405534015429 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 405534015430 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 405534015431 ATP binding site [chemical binding]; other site 405534015432 Mg++ binding site [ion binding]; other site 405534015433 motif III; other site 405534015434 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405534015435 nucleotide binding region [chemical binding]; other site 405534015436 ATP-binding site [chemical binding]; other site 405534015437 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 405534015438 RNA binding site [nucleotide binding]; other site 405534015439 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 405534015440 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 405534015441 active site 405534015442 oligoendopeptidase F; Region: pepF; TIGR00181 405534015443 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 405534015444 active site 405534015445 Zn binding site [ion binding]; other site 405534015446 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405534015447 FeS/SAM binding site; other site 405534015448 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 405534015449 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 405534015450 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 405534015451 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 405534015452 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 405534015453 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 405534015454 protein binding site [polypeptide binding]; other site 405534015455 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 405534015456 YycH protein; Region: YycI; pfam09648 405534015457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 405534015458 YycH protein; Region: YycH; pfam07435 405534015459 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 405534015460 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 405534015461 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405534015462 dimerization interface [polypeptide binding]; other site 405534015463 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405534015464 putative active site [active] 405534015465 heme pocket [chemical binding]; other site 405534015466 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405534015467 dimer interface [polypeptide binding]; other site 405534015468 phosphorylation site [posttranslational modification] 405534015469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405534015470 ATP binding site [chemical binding]; other site 405534015471 Mg2+ binding site [ion binding]; other site 405534015472 G-X-G motif; other site 405534015473 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405534015474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405534015475 active site 405534015476 phosphorylation site [posttranslational modification] 405534015477 intermolecular recognition site; other site 405534015478 dimerization interface [polypeptide binding]; other site 405534015479 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405534015480 DNA binding site [nucleotide binding] 405534015481 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 405534015482 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 405534015483 GDP-binding site [chemical binding]; other site 405534015484 ACT binding site; other site 405534015485 IMP binding site; other site 405534015486 replicative DNA helicase; Provisional; Region: PRK05748 405534015487 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 405534015488 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 405534015489 Walker A motif; other site 405534015490 ATP binding site [chemical binding]; other site 405534015491 Walker B motif; other site 405534015492 DNA binding loops [nucleotide binding] 405534015493 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 405534015494 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 405534015495 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 405534015496 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 405534015497 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 405534015498 DHH family; Region: DHH; pfam01368 405534015499 DHHA1 domain; Region: DHHA1; pfam02272 405534015500 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 405534015501 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 405534015502 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 405534015503 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 405534015504 dimer interface [polypeptide binding]; other site 405534015505 ssDNA binding site [nucleotide binding]; other site 405534015506 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405534015507 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 405534015508 GTP-binding protein YchF; Reviewed; Region: PRK09601 405534015509 YchF GTPase; Region: YchF; cd01900 405534015510 G1 box; other site 405534015511 GTP/Mg2+ binding site [chemical binding]; other site 405534015512 Switch I region; other site 405534015513 G2 box; other site 405534015514 Switch II region; other site 405534015515 G3 box; other site 405534015516 G4 box; other site 405534015517 G5 box; other site 405534015518 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 405534015519 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 405534015520 Mechanosensitive ion channel; Region: MS_channel; pfam00924 405534015521 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 405534015522 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 405534015523 ParB-like nuclease domain; Region: ParB; smart00470 405534015524 KorB domain; Region: KorB; pfam08535 405534015525 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 405534015526 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 405534015527 P-loop; other site 405534015528 Magnesium ion binding site [ion binding]; other site 405534015529 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 405534015530 Magnesium ion binding site [ion binding]; other site 405534015531 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 405534015532 ParB-like nuclease domain; Region: ParBc; pfam02195 405534015533 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 405534015534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405534015535 S-adenosylmethionine binding site [chemical binding]; other site 405534015536 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 405534015537 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 405534015538 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 405534015539 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 405534015540 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 405534015541 trmE is a tRNA modification GTPase; Region: trmE; cd04164 405534015542 G1 box; other site 405534015543 GTP/Mg2+ binding site [chemical binding]; other site 405534015544 Switch I region; other site 405534015545 G2 box; other site 405534015546 Switch II region; other site 405534015547 G3 box; other site 405534015548 G4 box; other site 405534015549 G5 box; other site 405534015550 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 405534015551 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 405534015552 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 405534015553 G-X-X-G motif; other site 405534015554 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 405534015555 RxxxH motif; other site 405534015556 OxaA-like protein precursor; Validated; Region: PRK02944 405534015557 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 405534015558 ribonuclease P; Reviewed; Region: rnpA; PRK00499 405534015559 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399