-- dump date 20140618_214224 -- class Genbank::misc_feature -- table misc_feature_note -- id note 405535000001 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405535000002 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535000003 Coenzyme A binding pocket [chemical binding]; other site 405535000004 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405535000005 Protein of unknown function (DUF421); Region: DUF421; cl00990 405535000006 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405535000007 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 405535000008 DNA binding residues [nucleotide binding] 405535000009 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 405535000010 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 405535000011 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 405535000012 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 405535000013 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 405535000014 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 405535000015 putative dimer interface [polypeptide binding]; other site 405535000016 MarR family; Region: MarR_2; pfam12802 405535000017 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 405535000018 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 405535000019 DnaA N-terminal domain; Region: DnaA_N; pfam11638 405535000020 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535000021 Walker A motif; other site 405535000022 ATP binding site [chemical binding]; other site 405535000023 Walker B motif; other site 405535000024 arginine finger; other site 405535000025 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 405535000026 DnaA box-binding interface [nucleotide binding]; other site 405535000027 DNA polymerase III subunit beta; Validated; Region: PRK05643 405535000028 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 405535000029 putative DNA binding surface [nucleotide binding]; other site 405535000030 dimer interface [polypeptide binding]; other site 405535000031 beta-clamp/clamp loader binding surface; other site 405535000032 beta-clamp/translesion DNA polymerase binding surface; other site 405535000033 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 405535000034 recombination protein F; Reviewed; Region: recF; PRK00064 405535000035 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 405535000036 Walker A/P-loop; other site 405535000037 ATP binding site [chemical binding]; other site 405535000038 Q-loop/lid; other site 405535000039 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535000040 ABC transporter signature motif; other site 405535000041 Walker B; other site 405535000042 D-loop; other site 405535000043 H-loop/switch region; other site 405535000044 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 405535000045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535000046 Mg2+ binding site [ion binding]; other site 405535000047 G-X-G motif; other site 405535000048 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 405535000049 anchoring element; other site 405535000050 dimer interface [polypeptide binding]; other site 405535000051 ATP binding site [chemical binding]; other site 405535000052 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 405535000053 active site 405535000054 putative metal-binding site [ion binding]; other site 405535000055 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 405535000056 DNA gyrase subunit A; Validated; Region: PRK05560 405535000057 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 405535000058 CAP-like domain; other site 405535000059 active site 405535000060 primary dimer interface [polypeptide binding]; other site 405535000061 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405535000062 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405535000063 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405535000064 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405535000065 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405535000066 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405535000067 YaaC-like Protein; Region: YaaC; pfam14175 405535000068 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 405535000069 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 405535000070 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 405535000071 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 405535000072 active site 405535000073 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 405535000074 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405535000075 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 405535000076 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 405535000077 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 405535000078 active site 405535000079 multimer interface [polypeptide binding]; other site 405535000080 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 405535000081 predicted active site [active] 405535000082 catalytic triad [active] 405535000083 seryl-tRNA synthetase; Provisional; Region: PRK05431 405535000084 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 405535000085 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 405535000086 dimer interface [polypeptide binding]; other site 405535000087 active site 405535000088 motif 1; other site 405535000089 motif 2; other site 405535000090 motif 3; other site 405535000091 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 405535000092 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 405535000093 DNA binding residues [nucleotide binding] 405535000094 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 405535000095 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 405535000096 Substrate-binding site [chemical binding]; other site 405535000097 Substrate specificity [chemical binding]; other site 405535000098 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 405535000099 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 405535000100 Substrate-binding site [chemical binding]; other site 405535000101 Substrate specificity [chemical binding]; other site 405535000102 Isochorismatase family; Region: Isochorismatase; pfam00857 405535000103 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 405535000104 catalytic triad [active] 405535000105 conserved cis-peptide bond; other site 405535000106 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 405535000107 nucleoside/Zn binding site; other site 405535000108 dimer interface [polypeptide binding]; other site 405535000109 catalytic motif [active] 405535000110 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 405535000111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535000112 Walker A motif; other site 405535000113 ATP binding site [chemical binding]; other site 405535000114 Walker B motif; other site 405535000115 arginine finger; other site 405535000116 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 405535000117 hypothetical protein; Validated; Region: PRK00153 405535000118 recombination protein RecR; Reviewed; Region: recR; PRK00076 405535000119 RecR protein; Region: RecR; pfam02132 405535000120 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 405535000121 putative active site [active] 405535000122 putative metal-binding site [ion binding]; other site 405535000123 tetramer interface [polypeptide binding]; other site 405535000124 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 405535000125 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 405535000126 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 405535000127 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 405535000128 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 405535000129 homodimer interface [polypeptide binding]; other site 405535000130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535000131 catalytic residue [active] 405535000132 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 405535000133 thymidylate kinase; Validated; Region: tmk; PRK00698 405535000134 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 405535000135 TMP-binding site; other site 405535000136 ATP-binding site [chemical binding]; other site 405535000137 DNA polymerase III subunit delta'; Validated; Region: PRK08058 405535000138 DNA polymerase III subunit delta'; Validated; Region: PRK08485 405535000139 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 405535000140 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 405535000141 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 405535000142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535000143 S-adenosylmethionine binding site [chemical binding]; other site 405535000144 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 405535000145 GIY-YIG motif/motif A; other site 405535000146 putative active site [active] 405535000147 putative metal binding site [ion binding]; other site 405535000148 Predicted methyltransferases [General function prediction only]; Region: COG0313 405535000149 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 405535000150 putative SAM binding site [chemical binding]; other site 405535000151 putative homodimer interface [polypeptide binding]; other site 405535000152 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 405535000153 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 405535000154 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 405535000155 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 405535000156 active site 405535000157 HIGH motif; other site 405535000158 KMSKS motif; other site 405535000159 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 405535000160 tRNA binding surface [nucleotide binding]; other site 405535000161 anticodon binding site; other site 405535000162 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 405535000163 dimer interface [polypeptide binding]; other site 405535000164 putative tRNA-binding site [nucleotide binding]; other site 405535000165 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 405535000166 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 405535000167 active site 405535000168 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 405535000169 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 405535000170 putative active site [active] 405535000171 putative metal binding site [ion binding]; other site 405535000172 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 405535000173 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 405535000174 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535000175 S-adenosylmethionine binding site [chemical binding]; other site 405535000176 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 405535000177 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 405535000178 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405535000179 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 405535000180 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 405535000181 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 405535000182 pur operon repressor; Provisional; Region: PRK09213 405535000183 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 405535000184 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405535000185 active site 405535000186 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 405535000187 homotrimer interaction site [polypeptide binding]; other site 405535000188 putative active site [active] 405535000189 regulatory protein SpoVG; Reviewed; Region: PRK13259 405535000190 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 405535000191 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 405535000192 Substrate binding site; other site 405535000193 Mg++ binding site; other site 405535000194 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 405535000195 active site 405535000196 substrate binding site [chemical binding]; other site 405535000197 CoA binding site [chemical binding]; other site 405535000198 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 405535000199 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 405535000200 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405535000201 active site 405535000202 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 405535000203 putative active site [active] 405535000204 catalytic residue [active] 405535000205 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 405535000206 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 405535000207 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 405535000208 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405535000209 ATP binding site [chemical binding]; other site 405535000210 putative Mg++ binding site [ion binding]; other site 405535000211 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405535000212 nucleotide binding region [chemical binding]; other site 405535000213 ATP-binding site [chemical binding]; other site 405535000214 TRCF domain; Region: TRCF; pfam03461 405535000215 stage V sporulation protein T; Region: spore_V_T; TIGR02851 405535000216 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 405535000217 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405535000218 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 405535000219 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 405535000220 putative SAM binding site [chemical binding]; other site 405535000221 putative homodimer interface [polypeptide binding]; other site 405535000222 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 405535000223 homodimer interface [polypeptide binding]; other site 405535000224 metal binding site [ion binding]; metal-binding site 405535000225 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 405535000226 homodimer interface [polypeptide binding]; other site 405535000227 active site 405535000228 putative chemical substrate binding site [chemical binding]; other site 405535000229 metal binding site [ion binding]; metal-binding site 405535000230 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405535000231 RNA binding surface [nucleotide binding]; other site 405535000232 sporulation protein YabP; Region: spore_yabP; TIGR02892 405535000233 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 405535000234 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 405535000235 Septum formation initiator; Region: DivIC; pfam04977 405535000236 hypothetical protein; Provisional; Region: PRK08582 405535000237 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 405535000238 RNA binding site [nucleotide binding]; other site 405535000239 stage II sporulation protein E; Region: spore_II_E; TIGR02865 405535000240 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 405535000241 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 405535000242 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 405535000243 Ligand Binding Site [chemical binding]; other site 405535000244 TilS substrate binding domain; Region: TilS; pfam09179 405535000245 TilS substrate C-terminal domain; Region: TilS_C; smart00977 405535000246 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405535000247 active site 405535000248 FtsH Extracellular; Region: FtsH_ext; pfam06480 405535000249 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 405535000250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535000251 Walker A motif; other site 405535000252 ATP binding site [chemical binding]; other site 405535000253 Walker B motif; other site 405535000254 arginine finger; other site 405535000255 Peptidase family M41; Region: Peptidase_M41; pfam01434 405535000256 pantothenate kinase; Reviewed; Region: PRK13318 405535000257 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 405535000258 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 405535000259 dimerization interface [polypeptide binding]; other site 405535000260 domain crossover interface; other site 405535000261 redox-dependent activation switch; other site 405535000262 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 405535000263 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 405535000264 dimer interface [polypeptide binding]; other site 405535000265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535000266 catalytic residue [active] 405535000267 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 405535000268 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 405535000269 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 405535000270 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 405535000271 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 405535000272 glutamine binding [chemical binding]; other site 405535000273 catalytic triad [active] 405535000274 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 405535000275 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 405535000276 homodimer interface [polypeptide binding]; other site 405535000277 substrate-cofactor binding pocket; other site 405535000278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535000279 catalytic residue [active] 405535000280 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 405535000281 dihydropteroate synthase; Region: DHPS; TIGR01496 405535000282 substrate binding pocket [chemical binding]; other site 405535000283 dimer interface [polypeptide binding]; other site 405535000284 inhibitor binding site; inhibition site 405535000285 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 405535000286 homooctamer interface [polypeptide binding]; other site 405535000287 active site 405535000288 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 405535000289 catalytic center binding site [active] 405535000290 ATP binding site [chemical binding]; other site 405535000291 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405535000292 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535000293 non-specific DNA binding site [nucleotide binding]; other site 405535000294 salt bridge; other site 405535000295 sequence-specific DNA binding site [nucleotide binding]; other site 405535000296 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 405535000297 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 405535000298 FMN binding site [chemical binding]; other site 405535000299 active site 405535000300 catalytic residues [active] 405535000301 substrate binding site [chemical binding]; other site 405535000302 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 405535000303 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 405535000304 dimer interface [polypeptide binding]; other site 405535000305 putative anticodon binding site; other site 405535000306 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 405535000307 motif 1; other site 405535000308 active site 405535000309 motif 2; other site 405535000310 motif 3; other site 405535000311 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 405535000312 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 405535000313 UvrB/uvrC motif; Region: UVR; pfam02151 405535000314 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 405535000315 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 405535000316 ADP binding site [chemical binding]; other site 405535000317 phosphagen binding site; other site 405535000318 substrate specificity loop; other site 405535000319 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 405535000320 Clp amino terminal domain; Region: Clp_N; pfam02861 405535000321 Clp amino terminal domain; Region: Clp_N; pfam02861 405535000322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535000323 Walker A motif; other site 405535000324 ATP binding site [chemical binding]; other site 405535000325 Walker B motif; other site 405535000326 arginine finger; other site 405535000327 UvrB/uvrC motif; Region: UVR; pfam02151 405535000328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535000329 Walker A motif; other site 405535000330 ATP binding site [chemical binding]; other site 405535000331 Walker B motif; other site 405535000332 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 405535000333 DNA repair protein RadA; Provisional; Region: PRK11823 405535000334 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 405535000335 Walker A motif/ATP binding site; other site 405535000336 ATP binding site [chemical binding]; other site 405535000337 Walker B motif; other site 405535000338 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 405535000339 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 405535000340 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 405535000341 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 405535000342 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 405535000343 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 405535000344 putative active site [active] 405535000345 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 405535000346 substrate binding site; other site 405535000347 dimer interface; other site 405535000348 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 405535000349 homotrimer interaction site [polypeptide binding]; other site 405535000350 zinc binding site [ion binding]; other site 405535000351 CDP-binding sites; other site 405535000352 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 405535000353 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 405535000354 active site 405535000355 HIGH motif; other site 405535000356 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 405535000357 active site 405535000358 KMSKS motif; other site 405535000359 serine O-acetyltransferase; Region: cysE; TIGR01172 405535000360 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 405535000361 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 405535000362 trimer interface [polypeptide binding]; other site 405535000363 active site 405535000364 substrate binding site [chemical binding]; other site 405535000365 CoA binding site [chemical binding]; other site 405535000366 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 405535000367 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 405535000368 active site 405535000369 HIGH motif; other site 405535000370 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 405535000371 KMSKS motif; other site 405535000372 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 405535000373 tRNA binding surface [nucleotide binding]; other site 405535000374 anticodon binding site; other site 405535000375 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 405535000376 active site 405535000377 metal binding site [ion binding]; metal-binding site 405535000378 dimerization interface [polypeptide binding]; other site 405535000379 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 405535000380 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 405535000381 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 405535000382 YacP-like NYN domain; Region: NYN_YacP; pfam05991 405535000383 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 405535000384 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535000385 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 405535000386 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 405535000387 potential frameshift: common BLAST hit: gi|218231706|ref|YP_002364945.1| transcription antitermination protein NusG 405535000388 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 405535000389 putative homodimer interface [polypeptide binding]; other site 405535000390 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 405535000391 heterodimer interface [polypeptide binding]; other site 405535000392 homodimer interface [polypeptide binding]; other site 405535000393 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 405535000394 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 405535000395 23S rRNA interface [nucleotide binding]; other site 405535000396 L7/L12 interface [polypeptide binding]; other site 405535000397 putative thiostrepton binding site; other site 405535000398 L25 interface [polypeptide binding]; other site 405535000399 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 405535000400 mRNA/rRNA interface [nucleotide binding]; other site 405535000401 Ribosomal protein L10 leader 405535000402 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 405535000403 23S rRNA interface [nucleotide binding]; other site 405535000404 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 405535000405 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 405535000406 core dimer interface [polypeptide binding]; other site 405535000407 peripheral dimer interface [polypeptide binding]; other site 405535000408 L10 interface [polypeptide binding]; other site 405535000409 L11 interface [polypeptide binding]; other site 405535000410 putative EF-Tu interaction site [polypeptide binding]; other site 405535000411 putative EF-G interaction site [polypeptide binding]; other site 405535000412 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 405535000413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535000414 S-adenosylmethionine binding site [chemical binding]; other site 405535000415 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 405535000416 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 405535000417 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 405535000418 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 405535000419 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 405535000420 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 405535000421 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 405535000422 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 405535000423 RPB10 interaction site [polypeptide binding]; other site 405535000424 RPB1 interaction site [polypeptide binding]; other site 405535000425 RPB11 interaction site [polypeptide binding]; other site 405535000426 RPB3 interaction site [polypeptide binding]; other site 405535000427 RPB12 interaction site [polypeptide binding]; other site 405535000428 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 405535000429 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 405535000430 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 405535000431 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 405535000432 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 405535000433 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 405535000434 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 405535000435 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 405535000436 G-loop; other site 405535000437 DNA binding site [nucleotide binding] 405535000438 hypothetical protein; Provisional; Region: PRK06683 405535000439 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 405535000440 S17 interaction site [polypeptide binding]; other site 405535000441 S8 interaction site; other site 405535000442 16S rRNA interaction site [nucleotide binding]; other site 405535000443 streptomycin interaction site [chemical binding]; other site 405535000444 23S rRNA interaction site [nucleotide binding]; other site 405535000445 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 405535000446 30S ribosomal protein S7; Validated; Region: PRK05302 405535000447 elongation factor G; Reviewed; Region: PRK00007 405535000448 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 405535000449 G1 box; other site 405535000450 putative GEF interaction site [polypeptide binding]; other site 405535000451 GTP/Mg2+ binding site [chemical binding]; other site 405535000452 Switch I region; other site 405535000453 G2 box; other site 405535000454 G3 box; other site 405535000455 Switch II region; other site 405535000456 G4 box; other site 405535000457 G5 box; other site 405535000458 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 405535000459 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 405535000460 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 405535000461 elongation factor Tu; Reviewed; Region: PRK00049 405535000462 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 405535000463 G1 box; other site 405535000464 GEF interaction site [polypeptide binding]; other site 405535000465 GTP/Mg2+ binding site [chemical binding]; other site 405535000466 Switch I region; other site 405535000467 G2 box; other site 405535000468 G3 box; other site 405535000469 Switch II region; other site 405535000470 G4 box; other site 405535000471 G5 box; other site 405535000472 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 405535000473 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 405535000474 Antibiotic Binding Site [chemical binding]; other site 405535000475 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 405535000476 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 405535000477 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 405535000478 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 405535000479 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 405535000480 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 405535000481 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 405535000482 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 405535000483 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 405535000484 putative translocon binding site; other site 405535000485 protein-rRNA interface [nucleotide binding]; other site 405535000486 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 405535000487 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 405535000488 G-X-X-G motif; other site 405535000489 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 405535000490 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 405535000491 23S rRNA interface [nucleotide binding]; other site 405535000492 5S rRNA interface [nucleotide binding]; other site 405535000493 putative antibiotic binding site [chemical binding]; other site 405535000494 L25 interface [polypeptide binding]; other site 405535000495 L27 interface [polypeptide binding]; other site 405535000496 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 405535000497 23S rRNA interface [nucleotide binding]; other site 405535000498 putative translocon interaction site; other site 405535000499 signal recognition particle (SRP54) interaction site; other site 405535000500 L23 interface [polypeptide binding]; other site 405535000501 trigger factor interaction site; other site 405535000502 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 405535000503 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 405535000504 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 405535000505 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 405535000506 RNA binding site [nucleotide binding]; other site 405535000507 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 405535000508 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 405535000509 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 405535000510 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 405535000511 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 405535000512 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 405535000513 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 405535000514 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 405535000515 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 405535000516 5S rRNA interface [nucleotide binding]; other site 405535000517 L27 interface [polypeptide binding]; other site 405535000518 23S rRNA interface [nucleotide binding]; other site 405535000519 L5 interface [polypeptide binding]; other site 405535000520 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 405535000521 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 405535000522 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 405535000523 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 405535000524 23S rRNA binding site [nucleotide binding]; other site 405535000525 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 405535000526 potential frameshift: common BLAST hit: gi|217957705|ref|YP_002336249.1| preprotein translocase, SecY subunit 405535000527 SecY translocase; Region: SecY; pfam00344 405535000528 SecY translocase; Region: SecY; pfam00344 405535000529 adenylate kinase; Reviewed; Region: adk; PRK00279 405535000530 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 405535000531 AMP-binding site [chemical binding]; other site 405535000532 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 405535000533 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 405535000534 active site 405535000535 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 405535000536 rRNA binding site [nucleotide binding]; other site 405535000537 predicted 30S ribosome binding site; other site 405535000538 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 405535000539 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 405535000540 30S ribosomal protein S13; Region: bact_S13; TIGR03631 405535000541 30S ribosomal protein S11; Validated; Region: PRK05309 405535000542 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 405535000543 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 405535000544 alphaNTD - beta interaction site [polypeptide binding]; other site 405535000545 alphaNTD homodimer interface [polypeptide binding]; other site 405535000546 alphaNTD - beta' interaction site [polypeptide binding]; other site 405535000547 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 405535000548 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 405535000549 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 405535000550 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405535000551 Walker A/P-loop; other site 405535000552 ATP binding site [chemical binding]; other site 405535000553 Q-loop/lid; other site 405535000554 ABC transporter signature motif; other site 405535000555 Walker B; other site 405535000556 D-loop; other site 405535000557 H-loop/switch region; other site 405535000558 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 405535000559 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405535000560 Walker A/P-loop; other site 405535000561 ATP binding site [chemical binding]; other site 405535000562 Q-loop/lid; other site 405535000563 ABC transporter signature motif; other site 405535000564 Walker B; other site 405535000565 D-loop; other site 405535000566 H-loop/switch region; other site 405535000567 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 405535000568 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 405535000569 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 405535000570 dimerization interface 3.5A [polypeptide binding]; other site 405535000571 active site 405535000572 Ribosomal protein L13 leader 405535000573 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 405535000574 23S rRNA interface [nucleotide binding]; other site 405535000575 L3 interface [polypeptide binding]; other site 405535000576 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 405535000577 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 405535000578 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 405535000579 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405535000580 active site 405535000581 metal binding site [ion binding]; metal-binding site 405535000582 Domain of unknown function DUF59; Region: DUF59; pfam01883 405535000583 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 405535000584 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 405535000585 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 405535000586 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405535000587 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 405535000588 NodB motif; other site 405535000589 putative active site [active] 405535000590 putative catalytic site [active] 405535000591 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 405535000592 Arginase family; Region: Arginase; cd09989 405535000593 agmatinase; Region: agmatinase; TIGR01230 405535000594 active site 405535000595 Mn binding site [ion binding]; other site 405535000596 oligomer interface [polypeptide binding]; other site 405535000597 Uncharacterized conserved protein [Function unknown]; Region: COG1624 405535000598 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 405535000599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 405535000600 YbbR-like protein; Region: YbbR; pfam07949 405535000601 YbbR-like protein; Region: YbbR; pfam07949 405535000602 YbbR-like protein; Region: YbbR; pfam07949 405535000603 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 405535000604 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 405535000605 active site 405535000606 substrate binding site [chemical binding]; other site 405535000607 metal binding site [ion binding]; metal-binding site 405535000608 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 405535000609 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 405535000610 glutaminase active site [active] 405535000611 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 405535000612 dimer interface [polypeptide binding]; other site 405535000613 active site 405535000614 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 405535000615 dimer interface [polypeptide binding]; other site 405535000616 active site 405535000617 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405535000618 Transcriptional regulators [Transcription]; Region: GntR; COG1802 405535000619 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535000620 DNA-binding site [nucleotide binding]; DNA binding site 405535000621 FCD domain; Region: FCD; pfam07729 405535000622 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 405535000623 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 405535000624 N- and C-terminal domain interface [polypeptide binding]; other site 405535000625 active site 405535000626 catalytic site [active] 405535000627 metal binding site [ion binding]; metal-binding site 405535000628 carbohydrate binding site [chemical binding]; other site 405535000629 ATP binding site [chemical binding]; other site 405535000630 fructuronate transporter; Provisional; Region: PRK10034; cl15264 405535000631 gluconate transporter; Region: gntP; TIGR00791 405535000632 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405535000633 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 405535000634 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 405535000635 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 405535000636 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405535000637 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 405535000638 DoxX; Region: DoxX; cl17842 405535000639 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 405535000640 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 405535000641 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 405535000642 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535000643 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405535000644 DNA binding residues [nucleotide binding] 405535000645 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 405535000646 classical (c) SDRs; Region: SDR_c; cd05233 405535000647 NAD(P) binding site [chemical binding]; other site 405535000648 active site 405535000649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535000650 ABC-ATPase subunit interface; other site 405535000651 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 405535000652 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 405535000653 Walker A/P-loop; other site 405535000654 ATP binding site [chemical binding]; other site 405535000655 Q-loop/lid; other site 405535000656 ABC transporter signature motif; other site 405535000657 Walker B; other site 405535000658 D-loop; other site 405535000659 H-loop/switch region; other site 405535000660 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405535000661 NIL domain; Region: NIL; pfam09383 405535000662 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 405535000663 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 405535000664 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405535000665 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 405535000666 putative NAD(P) binding site [chemical binding]; other site 405535000667 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 405535000668 FAD binding domain; Region: FAD_binding_4; pfam01565 405535000669 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405535000670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535000671 putative substrate translocation pore; other site 405535000672 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 405535000673 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 405535000674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535000675 putative substrate translocation pore; other site 405535000676 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 405535000677 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 405535000678 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405535000679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535000680 dimer interface [polypeptide binding]; other site 405535000681 conserved gate region; other site 405535000682 putative PBP binding loops; other site 405535000683 ABC-ATPase subunit interface; other site 405535000684 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405535000685 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 405535000686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535000687 dimer interface [polypeptide binding]; other site 405535000688 conserved gate region; other site 405535000689 putative PBP binding loops; other site 405535000690 ABC-ATPase subunit interface; other site 405535000691 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 405535000692 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405535000693 Walker A/P-loop; other site 405535000694 ATP binding site [chemical binding]; other site 405535000695 Q-loop/lid; other site 405535000696 ABC transporter signature motif; other site 405535000697 Walker B; other site 405535000698 D-loop; other site 405535000699 H-loop/switch region; other site 405535000700 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405535000701 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 405535000702 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405535000703 Walker A/P-loop; other site 405535000704 ATP binding site [chemical binding]; other site 405535000705 Q-loop/lid; other site 405535000706 ABC transporter signature motif; other site 405535000707 Walker B; other site 405535000708 D-loop; other site 405535000709 H-loop/switch region; other site 405535000710 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 405535000711 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405535000712 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405535000713 peptide binding site [polypeptide binding]; other site 405535000714 YusW-like protein; Region: YusW; pfam14039 405535000715 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405535000716 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405535000717 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405535000718 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 405535000719 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405535000720 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405535000721 peptide binding site [polypeptide binding]; other site 405535000722 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405535000723 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405535000724 peptide binding site [polypeptide binding]; other site 405535000725 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405535000726 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405535000727 active site 405535000728 catalytic tetrad [active] 405535000729 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 405535000730 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 405535000731 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 405535000732 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 405535000733 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 405535000734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535000735 dimer interface [polypeptide binding]; other site 405535000736 conserved gate region; other site 405535000737 putative PBP binding loops; other site 405535000738 ABC-ATPase subunit interface; other site 405535000739 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 405535000740 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 405535000741 dimerization interface [polypeptide binding]; other site 405535000742 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405535000743 membrane-bound complex binding site; other site 405535000744 hinge residues; other site 405535000745 DNA binding domain, excisionase family; Region: excise; TIGR01764 405535000746 PBP superfamily domain; Region: PBP_like; pfam12727 405535000747 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405535000748 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405535000749 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 405535000750 putative dimerization interface [polypeptide binding]; other site 405535000751 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405535000752 EamA-like transporter family; Region: EamA; pfam00892 405535000753 YrzO-like protein; Region: YrzO; pfam14142 405535000754 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 405535000755 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 405535000756 putative acyl-acceptor binding pocket; other site 405535000757 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405535000758 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405535000759 DNA binding site [nucleotide binding] 405535000760 domain linker motif; other site 405535000761 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 405535000762 putative ligand binding site [chemical binding]; other site 405535000763 putative dimerization interface [polypeptide binding]; other site 405535000764 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405535000765 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405535000766 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405535000767 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405535000768 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405535000769 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 405535000770 active site 405535000771 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 405535000772 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 405535000773 C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441 405535000774 lysozyme catalytic site [active] 405535000775 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 405535000776 nucleotide binding site/active site [active] 405535000777 HIT family signature motif; other site 405535000778 catalytic residue [active] 405535000779 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405535000780 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405535000781 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405535000782 ABC transporter; Region: ABC_tran_2; pfam12848 405535000783 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405535000784 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 405535000785 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 405535000786 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405535000787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535000788 dimer interface [polypeptide binding]; other site 405535000789 conserved gate region; other site 405535000790 putative PBP binding loops; other site 405535000791 ABC-ATPase subunit interface; other site 405535000792 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405535000793 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 405535000794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535000795 dimer interface [polypeptide binding]; other site 405535000796 conserved gate region; other site 405535000797 putative PBP binding loops; other site 405535000798 ABC-ATPase subunit interface; other site 405535000799 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 405535000800 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405535000801 Walker A/P-loop; other site 405535000802 ATP binding site [chemical binding]; other site 405535000803 Q-loop/lid; other site 405535000804 ABC transporter signature motif; other site 405535000805 Walker B; other site 405535000806 D-loop; other site 405535000807 H-loop/switch region; other site 405535000808 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 405535000809 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 405535000810 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405535000811 Walker A/P-loop; other site 405535000812 ATP binding site [chemical binding]; other site 405535000813 Q-loop/lid; other site 405535000814 ABC transporter signature motif; other site 405535000815 Walker B; other site 405535000816 D-loop; other site 405535000817 H-loop/switch region; other site 405535000818 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 405535000819 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535000820 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405535000821 active site 405535000822 motif I; other site 405535000823 motif II; other site 405535000824 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535000825 motif II; other site 405535000826 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 405535000827 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 405535000828 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 405535000829 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 405535000830 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 405535000831 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 405535000832 dimer interface [polypeptide binding]; other site 405535000833 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 405535000834 active site 405535000835 Fe binding site [ion binding]; other site 405535000836 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 405535000837 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 405535000838 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 405535000839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535000840 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405535000841 putative substrate translocation pore; other site 405535000842 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 405535000843 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 405535000844 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 405535000845 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 405535000846 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 405535000847 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405535000848 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405535000849 helicase 45; Provisional; Region: PTZ00424 405535000850 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 405535000851 ATP binding site [chemical binding]; other site 405535000852 Mg++ binding site [ion binding]; other site 405535000853 motif III; other site 405535000854 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405535000855 nucleotide binding region [chemical binding]; other site 405535000856 ATP-binding site [chemical binding]; other site 405535000857 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 405535000858 Rhomboid family; Region: Rhomboid; pfam01694 405535000859 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 405535000860 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 405535000861 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 405535000862 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 405535000863 alanine racemase; Reviewed; Region: alr; PRK00053 405535000864 active site 405535000865 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405535000866 dimer interface [polypeptide binding]; other site 405535000867 substrate binding site [chemical binding]; other site 405535000868 catalytic residues [active] 405535000869 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 405535000870 PemK-like protein; Region: PemK; pfam02452 405535000871 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 405535000872 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 405535000873 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 405535000874 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 405535000875 RNA binding site [nucleotide binding]; other site 405535000876 hypothetical protein; Provisional; Region: PRK04351 405535000877 SprT homologues; Region: SprT; cl01182 405535000878 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 405535000879 Glycoprotease family; Region: Peptidase_M22; pfam00814 405535000880 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 405535000881 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 405535000882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535000883 Coenzyme A binding pocket [chemical binding]; other site 405535000884 UGMP family protein; Validated; Region: PRK09604 405535000885 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 405535000886 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 405535000887 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405535000888 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405535000889 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405535000890 ABC transporter; Region: ABC_tran_2; pfam12848 405535000891 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405535000892 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 405535000893 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 405535000894 CoA binding domain; Region: CoA_binding; pfam02629 405535000895 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 405535000896 CAAX protease self-immunity; Region: Abi; pfam02517 405535000897 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 405535000898 oligomerisation interface [polypeptide binding]; other site 405535000899 mobile loop; other site 405535000900 roof hairpin; other site 405535000901 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 405535000902 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 405535000903 ring oligomerisation interface [polypeptide binding]; other site 405535000904 ATP/Mg binding site [chemical binding]; other site 405535000905 stacking interactions; other site 405535000906 hinge regions; other site 405535000907 GMP synthase; Reviewed; Region: guaA; PRK00074 405535000908 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 405535000909 AMP/PPi binding site [chemical binding]; other site 405535000910 candidate oxyanion hole; other site 405535000911 catalytic triad [active] 405535000912 potential glutamine specificity residues [chemical binding]; other site 405535000913 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 405535000914 ATP Binding subdomain [chemical binding]; other site 405535000915 Ligand Binding sites [chemical binding]; other site 405535000916 Dimerization subdomain; other site 405535000917 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405535000918 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535000919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535000920 active site 405535000921 phosphorylation site [posttranslational modification] 405535000922 intermolecular recognition site; other site 405535000923 dimerization interface [polypeptide binding]; other site 405535000924 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535000925 DNA binding site [nucleotide binding] 405535000926 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535000927 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535000928 dimerization interface [polypeptide binding]; other site 405535000929 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535000930 dimer interface [polypeptide binding]; other site 405535000931 phosphorylation site [posttranslational modification] 405535000932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535000933 ATP binding site [chemical binding]; other site 405535000934 Mg2+ binding site [ion binding]; other site 405535000935 G-X-G motif; other site 405535000936 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405535000937 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405535000938 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405535000939 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 405535000940 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 405535000941 catalytic residues [active] 405535000942 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 405535000943 putative ligand binding site [chemical binding]; other site 405535000944 putative catalytic site [active] 405535000945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535000946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535000947 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 405535000948 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405535000949 UDP-glucose 4-epimerase (G4E), subgroup 5, extended (e) SDRs; Region: UDP_G4E_5_SDR_e; cd05264 405535000950 putative NAD(P) binding site [chemical binding]; other site 405535000951 active site 405535000952 putative substrate binding site [chemical binding]; other site 405535000953 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405535000954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535000955 S-adenosylmethionine binding site [chemical binding]; other site 405535000956 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405535000957 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 405535000958 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405535000959 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405535000960 active site 405535000961 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 405535000962 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405535000963 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405535000964 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 405535000965 Walker A/P-loop; other site 405535000966 ATP binding site [chemical binding]; other site 405535000967 Q-loop/lid; other site 405535000968 ABC transporter signature motif; other site 405535000969 Walker B; other site 405535000970 D-loop; other site 405535000971 H-loop/switch region; other site 405535000972 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535000973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535000974 dimer interface [polypeptide binding]; other site 405535000975 phosphorylation site [posttranslational modification] 405535000976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535000977 ATP binding site [chemical binding]; other site 405535000978 Mg2+ binding site [ion binding]; other site 405535000979 G-X-G motif; other site 405535000980 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535000981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535000982 active site 405535000983 phosphorylation site [posttranslational modification] 405535000984 intermolecular recognition site; other site 405535000985 dimerization interface [polypeptide binding]; other site 405535000986 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535000987 DNA binding site [nucleotide binding] 405535000988 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 405535000989 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 405535000990 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 405535000991 NAD binding site [chemical binding]; other site 405535000992 ATP-grasp domain; Region: ATP-grasp; pfam02222 405535000993 adenylosuccinate lyase; Provisional; Region: PRK07492 405535000994 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 405535000995 tetramer interface [polypeptide binding]; other site 405535000996 active site 405535000997 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 405535000998 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 405535000999 ATP binding site [chemical binding]; other site 405535001000 active site 405535001001 substrate binding site [chemical binding]; other site 405535001002 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 405535001003 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 405535001004 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 405535001005 putative active site [active] 405535001006 catalytic triad [active] 405535001007 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 405535001008 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 405535001009 dimerization interface [polypeptide binding]; other site 405535001010 ATP binding site [chemical binding]; other site 405535001011 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 405535001012 dimerization interface [polypeptide binding]; other site 405535001013 ATP binding site [chemical binding]; other site 405535001014 amidophosphoribosyltransferase; Provisional; Region: PRK06781 405535001015 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 405535001016 active site 405535001017 tetramer interface [polypeptide binding]; other site 405535001018 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405535001019 active site 405535001020 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 405535001021 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 405535001022 dimerization interface [polypeptide binding]; other site 405535001023 putative ATP binding site [chemical binding]; other site 405535001024 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 405535001025 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 405535001026 active site 405535001027 substrate binding site [chemical binding]; other site 405535001028 cosubstrate binding site; other site 405535001029 catalytic site [active] 405535001030 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 405535001031 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 405535001032 purine monophosphate binding site [chemical binding]; other site 405535001033 dimer interface [polypeptide binding]; other site 405535001034 putative catalytic residues [active] 405535001035 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 405535001036 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 405535001037 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 405535001038 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 405535001039 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 405535001040 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 405535001041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 405535001042 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 405535001043 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 405535001044 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 405535001045 PcrB family; Region: PcrB; pfam01884 405535001046 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 405535001047 substrate binding site [chemical binding]; other site 405535001048 putative active site [active] 405535001049 dimer interface [polypeptide binding]; other site 405535001050 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 405535001051 Part of AAA domain; Region: AAA_19; pfam13245 405535001052 Family description; Region: UvrD_C_2; pfam13538 405535001053 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 405535001054 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 405535001055 nucleotide binding pocket [chemical binding]; other site 405535001056 K-X-D-G motif; other site 405535001057 catalytic site [active] 405535001058 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 405535001059 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 405535001060 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 405535001061 Dimer interface [polypeptide binding]; other site 405535001062 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 405535001063 putative dimer interface [polypeptide binding]; other site 405535001064 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 405535001065 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 405535001066 putative dimer interface [polypeptide binding]; other site 405535001067 hypothetical protein; Provisional; Region: PRK10621 405535001068 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405535001069 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 405535001070 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 405535001071 Glutamate binding site [chemical binding]; other site 405535001072 homodimer interface [polypeptide binding]; other site 405535001073 NAD binding site [chemical binding]; other site 405535001074 catalytic residues [active] 405535001075 Isochorismatase family; Region: Isochorismatase; pfam00857 405535001076 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 405535001077 catalytic triad [active] 405535001078 conserved cis-peptide bond; other site 405535001079 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 405535001080 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 405535001081 Walker A/P-loop; other site 405535001082 ATP binding site [chemical binding]; other site 405535001083 Q-loop/lid; other site 405535001084 ABC transporter signature motif; other site 405535001085 Walker B; other site 405535001086 D-loop; other site 405535001087 H-loop/switch region; other site 405535001088 NIL domain; Region: NIL; pfam09383 405535001089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535001090 dimer interface [polypeptide binding]; other site 405535001091 conserved gate region; other site 405535001092 ABC-ATPase subunit interface; other site 405535001093 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 405535001094 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 405535001095 Transposase; Region: HTH_Tnp_1; cl17663 405535001096 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405535001097 HTH-like domain; Region: HTH_21; pfam13276 405535001098 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 405535001099 Integrase core domain; Region: rve; pfam00665 405535001100 Integrase core domain; Region: rve_2; pfam13333 405535001101 Protein of unknown function (DUF3926); Region: DUF3926; pfam13080 405535001102 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 405535001103 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 405535001104 P loop; other site 405535001105 Nucleotide binding site [chemical binding]; other site 405535001106 DTAP/Switch II; other site 405535001107 Switch I; other site 405535001108 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 405535001109 putative dimer interface [polypeptide binding]; other site 405535001110 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405535001111 MarR family; Region: MarR; pfam01047 405535001112 MarR family; Region: MarR_2; cl17246 405535001113 yiaA/B two helix domain; Region: YiaAB; pfam05360 405535001114 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 405535001115 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 405535001116 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 405535001117 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 405535001118 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 405535001119 GatB domain; Region: GatB_Yqey; pfam02637 405535001120 putative lipid kinase; Reviewed; Region: PRK13337 405535001121 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 405535001122 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 405535001123 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535001124 motif II; other site 405535001125 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 405535001126 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405535001127 inhibitor-cofactor binding pocket; inhibition site 405535001128 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535001129 catalytic residue [active] 405535001130 PAS domain; Region: PAS_9; pfam13426 405535001131 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405535001132 putative active site [active] 405535001133 heme pocket [chemical binding]; other site 405535001134 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 405535001135 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535001136 Walker A motif; other site 405535001137 ATP binding site [chemical binding]; other site 405535001138 Walker B motif; other site 405535001139 arginine finger; other site 405535001140 succinic semialdehyde dehydrogenase; Region: PLN02278 405535001141 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 405535001142 tetramerization interface [polypeptide binding]; other site 405535001143 NAD(P) binding site [chemical binding]; other site 405535001144 catalytic residues [active] 405535001145 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405535001146 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 405535001147 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 405535001148 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405535001149 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 405535001150 putative active site [active] 405535001151 putative metal binding site [ion binding]; other site 405535001152 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405535001153 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 405535001154 putative active site [active] 405535001155 putative metal binding site [ion binding]; other site 405535001156 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405535001157 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405535001158 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405535001159 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 405535001160 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 405535001161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535001162 S-adenosylmethionine binding site [chemical binding]; other site 405535001163 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 405535001164 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 405535001165 FMN binding site [chemical binding]; other site 405535001166 active site 405535001167 catalytic residues [active] 405535001168 substrate binding site [chemical binding]; other site 405535001169 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 405535001170 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 405535001171 GAF domain; Region: GAF_2; pfam13185 405535001172 GAF domain; Region: GAF_3; pfam13492 405535001173 PAS fold; Region: PAS_4; pfam08448 405535001174 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535001175 dimer interface [polypeptide binding]; other site 405535001176 phosphorylation site [posttranslational modification] 405535001177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535001178 ATP binding site [chemical binding]; other site 405535001179 Mg2+ binding site [ion binding]; other site 405535001180 G-X-G motif; other site 405535001181 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 405535001182 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 405535001183 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 405535001184 Protein of unknown function DUF45; Region: DUF45; pfam01863 405535001185 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 405535001186 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 405535001187 active site 405535001188 Predicted transcriptional regulator [Transcription]; Region: COG3355 405535001189 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 405535001190 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405535001191 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 405535001192 metal binding site [ion binding]; metal-binding site 405535001193 putative dimer interface [polypeptide binding]; other site 405535001194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535001195 S-adenosylmethionine binding site [chemical binding]; other site 405535001196 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 405535001197 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 405535001198 catalytic residue [active] 405535001199 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 405535001200 catalytic residues [active] 405535001201 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405535001202 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405535001203 peroxiredoxin; Region: AhpC; TIGR03137 405535001204 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 405535001205 dimer interface [polypeptide binding]; other site 405535001206 decamer (pentamer of dimers) interface [polypeptide binding]; other site 405535001207 catalytic triad [active] 405535001208 peroxidatic and resolving cysteines [active] 405535001209 5-methylribose kinase; Reviewed; Region: PRK12396 405535001210 Phosphotransferase enzyme family; Region: APH; pfam01636 405535001211 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 405535001212 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 405535001213 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 405535001214 intersubunit interface [polypeptide binding]; other site 405535001215 active site 405535001216 Zn2+ binding site [ion binding]; other site 405535001217 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405535001218 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405535001219 ABC-ATPase subunit interface; other site 405535001220 dimer interface [polypeptide binding]; other site 405535001221 putative PBP binding regions; other site 405535001222 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405535001223 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405535001224 ABC-ATPase subunit interface; other site 405535001225 dimer interface [polypeptide binding]; other site 405535001226 putative PBP binding regions; other site 405535001227 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405535001228 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 405535001229 putative ligand binding residues [chemical binding]; other site 405535001230 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 405535001231 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405535001232 DNA binding domain, excisionase family; Region: excise; TIGR01764 405535001233 Sm and related proteins; Region: Sm_like; cl00259 405535001234 Sm1 motif; other site 405535001235 RNA binding site [nucleotide binding]; other site 405535001236 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 405535001237 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 405535001238 ATP binding site [chemical binding]; other site 405535001239 G-X-G motif; other site 405535001240 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 405535001241 hypothetical protein; Provisional; Region: PRK06851 405535001242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 405535001243 Walker A motif; other site 405535001244 ATP binding site [chemical binding]; other site 405535001245 NTPase; Region: NTPase_1; cl17478 405535001246 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 405535001247 benzoate transport; Region: 2A0115; TIGR00895 405535001248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535001249 putative substrate translocation pore; other site 405535001250 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 405535001251 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 405535001252 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 405535001253 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 405535001254 [2Fe-2S] cluster binding site [ion binding]; other site 405535001255 Fatty acid desaturase; Region: FA_desaturase; pfam00487 405535001256 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 405535001257 putative di-iron ligands [ion binding]; other site 405535001258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535001259 dimer interface [polypeptide binding]; other site 405535001260 conserved gate region; other site 405535001261 putative PBP binding loops; other site 405535001262 ABC-ATPase subunit interface; other site 405535001263 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 405535001264 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405535001265 substrate binding pocket [chemical binding]; other site 405535001266 membrane-bound complex binding site; other site 405535001267 hinge residues; other site 405535001268 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405535001269 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405535001270 Walker A/P-loop; other site 405535001271 ATP binding site [chemical binding]; other site 405535001272 Q-loop/lid; other site 405535001273 ABC transporter signature motif; other site 405535001274 Walker B; other site 405535001275 D-loop; other site 405535001276 H-loop/switch region; other site 405535001277 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 405535001278 HAMP domain; Region: HAMP; pfam00672 405535001279 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405535001280 dimer interface [polypeptide binding]; other site 405535001281 putative CheW interface [polypeptide binding]; other site 405535001282 Arginine repressor [Transcription]; Region: ArgR; COG1438 405535001283 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 405535001284 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 405535001285 arginine deiminase; Provisional; Region: PRK01388 405535001286 ornithine carbamoyltransferase; Validated; Region: PRK02102 405535001287 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 405535001288 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 405535001289 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 405535001290 carbamate kinase; Reviewed; Region: PRK12686 405535001291 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 405535001292 putative substrate binding site [chemical binding]; other site 405535001293 nucleotide binding site [chemical binding]; other site 405535001294 nucleotide binding site [chemical binding]; other site 405535001295 homodimer interface [polypeptide binding]; other site 405535001296 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 405535001297 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405535001298 ligand binding site [chemical binding]; other site 405535001299 flexible hinge region; other site 405535001300 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 405535001301 putative switch regulator; other site 405535001302 non-specific DNA interactions [nucleotide binding]; other site 405535001303 DNA binding site [nucleotide binding] 405535001304 sequence specific DNA binding site [nucleotide binding]; other site 405535001305 putative cAMP binding site [chemical binding]; other site 405535001306 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 405535001307 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 405535001308 Ca binding site [ion binding]; other site 405535001309 active site 405535001310 catalytic site [active] 405535001311 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405535001312 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 405535001313 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405535001314 active site turn [active] 405535001315 phosphorylation site [posttranslational modification] 405535001316 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 405535001317 putative catalytic site [active] 405535001318 putative metal binding site [ion binding]; other site 405535001319 putative phosphate binding site [ion binding]; other site 405535001320 Predicted membrane protein [Function unknown]; Region: COG1511 405535001321 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 405535001322 Predicted membrane protein [Function unknown]; Region: COG1511 405535001323 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 405535001324 dinuclear metal binding motif [ion binding]; other site 405535001325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535001326 DNA topoisomerase III; Provisional; Region: PRK07726 405535001327 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 405535001328 active site 405535001329 putative interdomain interaction site [polypeptide binding]; other site 405535001330 putative metal-binding site [ion binding]; other site 405535001331 putative nucleotide binding site [chemical binding]; other site 405535001332 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 405535001333 domain I; other site 405535001334 DNA binding groove [nucleotide binding] 405535001335 phosphate binding site [ion binding]; other site 405535001336 domain II; other site 405535001337 domain III; other site 405535001338 nucleotide binding site [chemical binding]; other site 405535001339 catalytic site [active] 405535001340 domain IV; other site 405535001341 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 405535001342 substrate binding site [chemical binding]; other site 405535001343 multimerization interface [polypeptide binding]; other site 405535001344 ATP binding site [chemical binding]; other site 405535001345 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 405535001346 thiamine phosphate binding site [chemical binding]; other site 405535001347 active site 405535001348 pyrophosphate binding site [ion binding]; other site 405535001349 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 405535001350 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 405535001351 HAMP domain; Region: HAMP; pfam00672 405535001352 dimerization interface [polypeptide binding]; other site 405535001353 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405535001354 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405535001355 dimer interface [polypeptide binding]; other site 405535001356 putative CheW interface [polypeptide binding]; other site 405535001357 Domain of unknown function DUF77; Region: DUF77; pfam01910 405535001358 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 405535001359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535001360 dimer interface [polypeptide binding]; other site 405535001361 conserved gate region; other site 405535001362 putative PBP binding loops; other site 405535001363 ABC-ATPase subunit interface; other site 405535001364 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 405535001365 NMT1/THI5 like; Region: NMT1; pfam09084 405535001366 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 405535001367 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 405535001368 Walker A/P-loop; other site 405535001369 ATP binding site [chemical binding]; other site 405535001370 Q-loop/lid; other site 405535001371 ABC transporter signature motif; other site 405535001372 Walker B; other site 405535001373 D-loop; other site 405535001374 H-loop/switch region; other site 405535001375 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405535001376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535001377 Walker A/P-loop; other site 405535001378 ATP binding site [chemical binding]; other site 405535001379 Q-loop/lid; other site 405535001380 ABC transporter signature motif; other site 405535001381 Walker B; other site 405535001382 D-loop; other site 405535001383 H-loop/switch region; other site 405535001384 ABC transporter; Region: ABC_tran_2; pfam12848 405535001385 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405535001386 Glyco_18 domain; Region: Glyco_18; smart00636 405535001387 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 405535001388 active site 405535001389 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405535001390 Interdomain contacts; other site 405535001391 Cytokine receptor motif; other site 405535001392 CBD_II domain; Region: CBD_II; smart00637 405535001393 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 405535001394 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405535001395 catalytic residues [active] 405535001396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535001397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535001398 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 405535001399 H+ Antiporter protein; Region: 2A0121; TIGR00900 405535001400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535001401 putative substrate translocation pore; other site 405535001402 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535001403 non-specific DNA binding site [nucleotide binding]; other site 405535001404 salt bridge; other site 405535001405 sequence-specific DNA binding site [nucleotide binding]; other site 405535001406 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 405535001407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535001408 putative substrate translocation pore; other site 405535001409 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 405535001410 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 405535001411 YesK-like protein; Region: YesK; pfam14150 405535001412 prolyl-tRNA synthetase; Provisional; Region: PRK08661 405535001413 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 405535001414 dimer interface [polypeptide binding]; other site 405535001415 motif 1; other site 405535001416 active site 405535001417 motif 2; other site 405535001418 motif 3; other site 405535001419 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 405535001420 anticodon binding site; other site 405535001421 zinc-binding site [ion binding]; other site 405535001422 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 405535001423 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405535001424 nucleotide binding site [chemical binding]; other site 405535001425 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 405535001426 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 405535001427 putative metal binding site [ion binding]; other site 405535001428 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 405535001429 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 405535001430 putative metal binding site [ion binding]; other site 405535001431 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 405535001432 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 405535001433 putative metal binding site [ion binding]; other site 405535001434 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 405535001435 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 405535001436 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 405535001437 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 405535001438 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 405535001439 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405535001440 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 405535001441 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 405535001442 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 405535001443 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 405535001444 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 405535001445 Low molecular weight phosphatase family; Region: LMWPc; cd00115 405535001446 active site 405535001447 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 405535001448 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 405535001449 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 405535001450 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405535001451 Soluble P-type ATPase [General function prediction only]; Region: COG4087 405535001452 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405535001453 EamA-like transporter family; Region: EamA; pfam00892 405535001454 EamA-like transporter family; Region: EamA; pfam00892 405535001455 YhhN-like protein; Region: YhhN; pfam07947 405535001456 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405535001457 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405535001458 Catalytic site [active] 405535001459 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535001460 binding surface 405535001461 Tetratricopeptide repeat; Region: TPR_16; pfam13432 405535001462 TPR motif; other site 405535001463 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405535001464 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405535001465 Predicted membrane protein [Function unknown]; Region: COG2510 405535001466 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 405535001467 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 405535001468 calcium/proton exchanger (cax); Region: cax; TIGR00378 405535001469 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 405535001470 YfkD-like protein; Region: YfkD; pfam14167 405535001471 Radical SAM superfamily; Region: Radical_SAM; pfam04055 405535001472 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405535001473 FeS/SAM binding site; other site 405535001474 YfkB-like domain; Region: YfkB; pfam08756 405535001475 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 405535001476 Fumarase C-terminus; Region: Fumerase_C; pfam05683 405535001477 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 405535001478 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 405535001479 NodB motif; other site 405535001480 active site 405535001481 catalytic site [active] 405535001482 Cd binding site [ion binding]; other site 405535001483 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 405535001484 endonuclease III; Region: ENDO3c; smart00478 405535001485 minor groove reading motif; other site 405535001486 helix-hairpin-helix signature motif; other site 405535001487 substrate binding pocket [chemical binding]; other site 405535001488 active site 405535001489 TRAM domain; Region: TRAM; pfam01938 405535001490 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 405535001491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535001492 S-adenosylmethionine binding site [chemical binding]; other site 405535001493 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 405535001494 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 405535001495 dimerization interface 3.5A [polypeptide binding]; other site 405535001496 active site 405535001497 acetylornithine deacetylase; Validated; Region: PRK08596 405535001498 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 405535001499 metal binding site [ion binding]; metal-binding site 405535001500 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405535001501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535001502 non-specific DNA binding site [nucleotide binding]; other site 405535001503 salt bridge; other site 405535001504 sequence-specific DNA binding site [nucleotide binding]; other site 405535001505 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 405535001506 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 405535001507 Domain of unknown function DUF; Region: DUF204; pfam02659 405535001508 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 405535001509 glutaminase A; Region: Gln_ase; TIGR03814 405535001510 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 405535001511 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 405535001512 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405535001513 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405535001514 active site turn [active] 405535001515 phosphorylation site [posttranslational modification] 405535001516 Beta-lactamase; Region: Beta-lactamase; pfam00144 405535001517 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405535001518 Sm and related proteins; Region: Sm_like; cl00259 405535001519 heptamer interface [polypeptide binding]; other site 405535001520 Sm1 motif; other site 405535001521 hexamer interface [polypeptide binding]; other site 405535001522 RNA binding site [nucleotide binding]; other site 405535001523 Sm2 motif; other site 405535001524 Sm and related proteins; Region: Sm_like; cl00259 405535001525 heptamer interface [polypeptide binding]; other site 405535001526 Sm1 motif; other site 405535001527 hexamer interface [polypeptide binding]; other site 405535001528 RNA binding site [nucleotide binding]; other site 405535001529 Sm2 motif; other site 405535001530 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 405535001531 active site 405535001532 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405535001533 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 405535001534 active site 405535001535 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 405535001536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405535001537 NAD(P) binding site [chemical binding]; other site 405535001538 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 405535001539 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 405535001540 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405535001541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405535001542 NAD(P) binding site [chemical binding]; other site 405535001543 active site 405535001544 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405535001545 active site 405535001546 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405535001547 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405535001548 active site 405535001549 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 405535001550 Pyruvate formate lyase 1; Region: PFL1; cd01678 405535001551 coenzyme A binding site [chemical binding]; other site 405535001552 active site 405535001553 catalytic residues [active] 405535001554 glycine loop; other site 405535001555 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 405535001556 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405535001557 FeS/SAM binding site; other site 405535001558 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 405535001559 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 405535001560 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 405535001561 YfhE-like protein; Region: YfhE; pfam14152 405535001562 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405535001563 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 405535001564 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 405535001565 active site 405535001566 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 405535001567 TIGR01777 family protein; Region: yfcH 405535001568 putative NAD(P) binding site [chemical binding]; other site 405535001569 putative active site [active] 405535001570 recombination regulator RecX; Provisional; Region: recX; PRK14135 405535001571 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 405535001572 YpzG-like protein; Region: YpzG; pfam14139 405535001573 Small acid-soluble spore protein K family; Region: SspK; pfam08176 405535001574 WVELL protein; Region: WVELL; pfam14043 405535001575 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 405535001576 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 405535001577 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 405535001578 minor groove reading motif; other site 405535001579 helix-hairpin-helix signature motif; other site 405535001580 substrate binding pocket [chemical binding]; other site 405535001581 active site 405535001582 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 405535001583 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 405535001584 DNA binding and oxoG recognition site [nucleotide binding] 405535001585 YgaB-like protein; Region: YgaB; pfam14182 405535001586 Transposase; Region: HTH_Tnp_1; pfam01527 405535001587 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405535001588 HTH-like domain; Region: HTH_21; pfam13276 405535001589 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 405535001590 Integrase core domain; Region: rve; pfam00665 405535001591 Integrase core domain; Region: rve_2; pfam13333 405535001592 hypothetical protein; Provisional; Region: PRK13662 405535001593 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405535001594 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405535001595 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 405535001596 Walker A/P-loop; other site 405535001597 ATP binding site [chemical binding]; other site 405535001598 Q-loop/lid; other site 405535001599 ABC transporter signature motif; other site 405535001600 Walker B; other site 405535001601 D-loop; other site 405535001602 H-loop/switch region; other site 405535001603 Predicted membrane protein [Function unknown]; Region: COG4129 405535001604 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 405535001605 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 405535001606 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 405535001607 active site 405535001608 dimer interface [polypeptide binding]; other site 405535001609 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 405535001610 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 405535001611 active site 405535001612 FMN binding site [chemical binding]; other site 405535001613 substrate binding site [chemical binding]; other site 405535001614 3Fe-4S cluster binding site [ion binding]; other site 405535001615 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 405535001616 domain_subunit interface; other site 405535001617 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 405535001618 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405535001619 inhibitor-cofactor binding pocket; inhibition site 405535001620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535001621 catalytic residue [active] 405535001622 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 405535001623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535001624 Walker A/P-loop; other site 405535001625 ATP binding site [chemical binding]; other site 405535001626 Q-loop/lid; other site 405535001627 ABC transporter signature motif; other site 405535001628 Walker B; other site 405535001629 D-loop; other site 405535001630 H-loop/switch region; other site 405535001631 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 405535001632 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 405535001633 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 405535001634 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 405535001635 Ion channel; Region: Ion_trans_2; pfam07885 405535001636 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 405535001637 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 405535001638 catalytic triad [active] 405535001639 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 405535001640 metal binding site 2 [ion binding]; metal-binding site 405535001641 putative DNA binding helix; other site 405535001642 metal binding site 1 [ion binding]; metal-binding site 405535001643 dimer interface [polypeptide binding]; other site 405535001644 structural Zn2+ binding site [ion binding]; other site 405535001645 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 405535001646 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 405535001647 hypothetical protein; Provisional; Region: PRK12378 405535001648 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405535001649 nudix motif; other site 405535001650 Transglycosylase; Region: Transgly; pfam00912 405535001651 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 405535001652 Thioredoxin; Region: Thioredoxin_4; pfam13462 405535001653 epoxyqueuosine reductase; Region: TIGR00276 405535001654 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 405535001655 Putative amidase domain; Region: Amidase_6; pfam12671 405535001656 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 405535001657 PAS fold; Region: PAS_4; pfam08448 405535001658 PAS domain S-box; Region: sensory_box; TIGR00229 405535001659 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405535001660 putative active site [active] 405535001661 heme pocket [chemical binding]; other site 405535001662 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405535001663 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405535001664 metal binding site [ion binding]; metal-binding site 405535001665 active site 405535001666 I-site; other site 405535001667 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405535001668 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 405535001669 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 405535001670 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 405535001671 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405535001672 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 405535001673 catalytic residues [active] 405535001674 catalytic nucleophile [active] 405535001675 Recombinase; Region: Recombinase; pfam07508 405535001676 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 405535001677 Domain of unknown function (DUF955); Region: DUF955; cl01076 405535001678 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405535001679 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535001680 non-specific DNA binding site [nucleotide binding]; other site 405535001681 salt bridge; other site 405535001682 sequence-specific DNA binding site [nucleotide binding]; other site 405535001683 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535001684 sequence-specific DNA binding site [nucleotide binding]; other site 405535001685 salt bridge; other site 405535001686 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 405535001687 replicative DNA helicase; Provisional; Region: PRK06749 405535001688 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 405535001689 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 405535001690 Walker A motif; other site 405535001691 ATP binding site [chemical binding]; other site 405535001692 Walker B motif; other site 405535001693 DNA binding loops [nucleotide binding] 405535001694 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 405535001695 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 405535001696 trimer interface [polypeptide binding]; other site 405535001697 active site 405535001698 YopX protein; Region: YopX; pfam09643 405535001699 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 405535001700 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 405535001701 Int/Topo IB signature motif; other site 405535001702 HNH endonuclease; Region: HNH; pfam01844 405535001703 Phage terminase, small subunit; Region: Terminase_4; cl01525 405535001704 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 405535001705 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 405535001706 Phage-related protein [Function unknown]; Region: COG4695; cl01923 405535001707 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 405535001708 oligomer interface [polypeptide binding]; other site 405535001709 active site residues [active] 405535001710 Phage capsid family; Region: Phage_capsid; pfam05065 405535001711 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 405535001712 Group I catalytic intron 405535001713 Phage-related protein [Function unknown]; Region: COG5412 405535001714 membrane protein P6; Region: PHA01399 405535001715 Phage tail protein; Region: Sipho_tail; cl17486 405535001716 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 405535001717 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 405535001718 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 405535001719 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 405535001720 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 405535001721 active site 405535001722 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 405535001723 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 405535001724 Protein of unknown function (DUF444); Region: DUF444; cl17371 405535001725 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405535001726 heme-binding site [chemical binding]; other site 405535001727 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405535001728 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405535001729 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 405535001730 Leucine-rich repeats; other site 405535001731 Substrate binding site [chemical binding]; other site 405535001732 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405535001733 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405535001734 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405535001735 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405535001736 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405535001737 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 405535001738 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535001739 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405535001740 Coenzyme A binding pocket [chemical binding]; other site 405535001741 BCCT family transporter; Region: BCCT; pfam02028 405535001742 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 405535001743 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 405535001744 FOG: PKD repeat [General function prediction only]; Region: COG3291 405535001745 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 405535001746 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 405535001747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 405535001748 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 405535001749 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 405535001750 Cache domain; Region: Cache_1; pfam02743 405535001751 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535001752 dimerization interface [polypeptide binding]; other site 405535001753 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405535001754 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405535001755 dimer interface [polypeptide binding]; other site 405535001756 putative CheW interface [polypeptide binding]; other site 405535001757 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 405535001758 PAS domain; Region: PAS; smart00091 405535001759 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535001760 ATP binding site [chemical binding]; other site 405535001761 Mg2+ binding site [ion binding]; other site 405535001762 G-X-G motif; other site 405535001763 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 405535001764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535001765 active site 405535001766 phosphorylation site [posttranslational modification] 405535001767 intermolecular recognition site; other site 405535001768 dimerization interface [polypeptide binding]; other site 405535001769 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 405535001770 Citrate transporter; Region: CitMHS; pfam03600 405535001771 hypothetical protein; Provisional; Region: PRK12784 405535001772 NosL; Region: NosL; cl01769 405535001773 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 405535001774 Ankyrin repeat; Region: Ank; pfam00023 405535001775 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 405535001776 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 405535001777 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 405535001778 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 405535001779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535001780 Walker A/P-loop; other site 405535001781 ATP binding site [chemical binding]; other site 405535001782 Q-loop/lid; other site 405535001783 ABC transporter signature motif; other site 405535001784 Walker B; other site 405535001785 D-loop; other site 405535001786 H-loop/switch region; other site 405535001787 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 405535001788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535001789 dimer interface [polypeptide binding]; other site 405535001790 conserved gate region; other site 405535001791 putative PBP binding loops; other site 405535001792 ABC-ATPase subunit interface; other site 405535001793 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 405535001794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 405535001795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535001796 dimer interface [polypeptide binding]; other site 405535001797 conserved gate region; other site 405535001798 putative PBP binding loops; other site 405535001799 ABC-ATPase subunit interface; other site 405535001800 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 405535001801 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 405535001802 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405535001803 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 405535001804 active site 405535001805 metal binding site [ion binding]; metal-binding site 405535001806 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535001807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535001808 active site 405535001809 phosphorylation site [posttranslational modification] 405535001810 intermolecular recognition site; other site 405535001811 dimerization interface [polypeptide binding]; other site 405535001812 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535001813 DNA binding site [nucleotide binding] 405535001814 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535001815 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535001816 dimer interface [polypeptide binding]; other site 405535001817 phosphorylation site [posttranslational modification] 405535001818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535001819 ATP binding site [chemical binding]; other site 405535001820 Mg2+ binding site [ion binding]; other site 405535001821 G-X-G motif; other site 405535001822 leucyl-tRNA synthetase; Reviewed; Region: leuS; PRK12300 405535001823 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 405535001824 putative active site [active] 405535001825 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 405535001826 Cache domain; Region: Cache_1; pfam02743 405535001827 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535001828 dimerization interface [polypeptide binding]; other site 405535001829 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405535001830 dimer interface [polypeptide binding]; other site 405535001831 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405535001832 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405535001833 dimer interface [polypeptide binding]; other site 405535001834 putative CheW interface [polypeptide binding]; other site 405535001835 sensory histidine kinase DcuS; Provisional; Region: PRK11086 405535001836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535001837 ATP binding site [chemical binding]; other site 405535001838 Mg2+ binding site [ion binding]; other site 405535001839 G-X-G motif; other site 405535001840 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 405535001841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535001842 active site 405535001843 phosphorylation site [posttranslational modification] 405535001844 intermolecular recognition site; other site 405535001845 dimerization interface [polypeptide binding]; other site 405535001846 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 405535001847 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 405535001848 Malic enzyme, N-terminal domain; Region: malic; pfam00390 405535001849 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 405535001850 putative NAD(P) binding site [chemical binding]; other site 405535001851 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405535001852 EamA-like transporter family; Region: EamA; pfam00892 405535001853 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405535001854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535001855 DNA-binding site [nucleotide binding]; DNA binding site 405535001856 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405535001857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535001858 homodimer interface [polypeptide binding]; other site 405535001859 catalytic residue [active] 405535001860 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 405535001861 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535001862 Coenzyme A binding pocket [chemical binding]; other site 405535001863 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535001864 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535001865 dimerization interface [polypeptide binding]; other site 405535001866 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535001867 dimer interface [polypeptide binding]; other site 405535001868 phosphorylation site [posttranslational modification] 405535001869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535001870 ATP binding site [chemical binding]; other site 405535001871 Mg2+ binding site [ion binding]; other site 405535001872 G-X-G motif; other site 405535001873 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535001874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535001875 active site 405535001876 phosphorylation site [posttranslational modification] 405535001877 intermolecular recognition site; other site 405535001878 dimerization interface [polypeptide binding]; other site 405535001879 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535001880 DNA binding site [nucleotide binding] 405535001881 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 405535001882 Arrestin_N terminal like; Region: LDB19; pfam13002 405535001883 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535001884 Coenzyme A binding pocket [chemical binding]; other site 405535001885 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 405535001886 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 405535001887 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 405535001888 catalytic loop [active] 405535001889 iron binding site [ion binding]; other site 405535001890 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 405535001891 4Fe-4S binding domain; Region: Fer4; pfam00037 405535001892 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 405535001893 [4Fe-4S] binding site [ion binding]; other site 405535001894 molybdopterin cofactor binding site; other site 405535001895 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 405535001896 molybdopterin cofactor binding site; other site 405535001897 Uncharacterized conserved protein [Function unknown]; Region: COG2427 405535001898 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 405535001899 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 405535001900 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 405535001901 putative active site [active] 405535001902 catalytic site [active] 405535001903 putative metal binding site [ion binding]; other site 405535001904 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 405535001905 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 405535001906 hexamer interface [polypeptide binding]; other site 405535001907 ligand binding site [chemical binding]; other site 405535001908 putative active site [active] 405535001909 NAD(P) binding site [chemical binding]; other site 405535001910 amino acid transporter; Region: 2A0306; TIGR00909 405535001911 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 405535001912 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535001913 dimerization interface [polypeptide binding]; other site 405535001914 putative DNA binding site [nucleotide binding]; other site 405535001915 putative Zn2+ binding site [ion binding]; other site 405535001916 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405535001917 metal-binding site [ion binding] 405535001918 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 405535001919 Heavy-metal-associated domain; Region: HMA; pfam00403 405535001920 metal-binding site [ion binding] 405535001921 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405535001922 Soluble P-type ATPase [General function prediction only]; Region: COG4087 405535001923 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 405535001924 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 405535001925 active site 405535001926 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405535001927 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535001928 non-specific DNA binding site [nucleotide binding]; other site 405535001929 salt bridge; other site 405535001930 sequence-specific DNA binding site [nucleotide binding]; other site 405535001931 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405535001932 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 405535001933 TPR motif; other site 405535001934 binding surface 405535001935 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405535001936 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405535001937 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 405535001938 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 405535001939 active site 405535001940 Zn binding site [ion binding]; other site 405535001941 Uncharacterized conserved protein [Function unknown]; Region: COG0398 405535001942 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405535001943 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 405535001944 VanW like protein; Region: VanW; pfam04294 405535001945 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 405535001946 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405535001947 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405535001948 Nucleoside recognition; Region: Gate; pfam07670 405535001949 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405535001950 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 405535001951 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405535001952 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 405535001953 Domain of unknown function DUF21; Region: DUF21; pfam01595 405535001954 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 405535001955 Transporter associated domain; Region: CorC_HlyC; smart01091 405535001956 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 405535001957 Aspartase; Region: Aspartase; cd01357 405535001958 active sites [active] 405535001959 tetramer interface [polypeptide binding]; other site 405535001960 L-lactate permease; Region: Lactate_perm; cl00701 405535001961 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 405535001962 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535001963 dimerization interface [polypeptide binding]; other site 405535001964 putative Zn2+ binding site [ion binding]; other site 405535001965 putative DNA binding site [nucleotide binding]; other site 405535001966 acid-soluble spore protein H; Provisional; Region: sspH; PRK01625 405535001967 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 405535001968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535001969 putative substrate translocation pore; other site 405535001970 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 405535001971 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 405535001972 siderophore binding site; other site 405535001973 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405535001974 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405535001975 ABC-ATPase subunit interface; other site 405535001976 dimer interface [polypeptide binding]; other site 405535001977 putative PBP binding regions; other site 405535001978 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405535001979 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405535001980 ABC-ATPase subunit interface; other site 405535001981 dimer interface [polypeptide binding]; other site 405535001982 putative PBP binding regions; other site 405535001983 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405535001984 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405535001985 Walker A/P-loop; other site 405535001986 ATP binding site [chemical binding]; other site 405535001987 Q-loop/lid; other site 405535001988 ABC transporter signature motif; other site 405535001989 Walker B; other site 405535001990 D-loop; other site 405535001991 H-loop/switch region; other site 405535001992 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405535001993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535001994 S-adenosylmethionine binding site [chemical binding]; other site 405535001995 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 405535001996 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 405535001997 substrate-cofactor binding pocket; other site 405535001998 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535001999 catalytic residue [active] 405535002000 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405535002001 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 405535002002 NAD binding site [chemical binding]; other site 405535002003 homodimer interface [polypeptide binding]; other site 405535002004 active site 405535002005 putative substrate binding site [chemical binding]; other site 405535002006 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405535002007 nudix motif; other site 405535002008 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 405535002009 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 405535002010 metal ion-dependent adhesion site (MIDAS); other site 405535002011 MoxR-like ATPases [General function prediction only]; Region: COG0714 405535002012 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535002013 Walker A motif; other site 405535002014 ATP binding site [chemical binding]; other site 405535002015 Walker B motif; other site 405535002016 arginine finger; other site 405535002017 cardiolipin synthetase; Reviewed; Region: PRK12452 405535002018 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 405535002019 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405535002020 putative active site [active] 405535002021 catalytic site [active] 405535002022 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 405535002023 putative active site [active] 405535002024 catalytic site [active] 405535002025 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405535002026 PAS domain; Region: PAS_9; pfam13426 405535002027 putative active site [active] 405535002028 heme pocket [chemical binding]; other site 405535002029 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405535002030 metal binding site [ion binding]; metal-binding site 405535002031 active site 405535002032 I-site; other site 405535002033 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405535002034 Amino acid permease; Region: AA_permease_2; pfam13520 405535002035 Spore germination protein; Region: Spore_permease; cl17796 405535002036 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535002037 DNA-binding site [nucleotide binding]; DNA binding site 405535002038 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 405535002039 UTRA domain; Region: UTRA; pfam07702 405535002040 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 405535002041 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405535002042 active site turn [active] 405535002043 phosphorylation site [posttranslational modification] 405535002044 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405535002045 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 405535002046 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 405535002047 Ca binding site [ion binding]; other site 405535002048 active site 405535002049 catalytic site [active] 405535002050 potential frameshift: common BLAST hit: gi|49183625|ref|YP_026877.1| spore germination protein GerKC 405535002051 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405535002052 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405535002053 Spore germination protein; Region: Spore_permease; cl17796 405535002054 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405535002055 CAAX protease self-immunity; Region: Abi; pfam02517 405535002056 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405535002057 active site 405535002058 ATP binding site [chemical binding]; other site 405535002059 substrate binding site [chemical binding]; other site 405535002060 potential frameshift: common BLAST hit: gi|49480224|ref|YP_034896.1| sodium/alanine symporter family protein 405535002061 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405535002062 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 405535002063 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 405535002064 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405535002065 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405535002066 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405535002067 Walker A/P-loop; other site 405535002068 ATP binding site [chemical binding]; other site 405535002069 Q-loop/lid; other site 405535002070 ABC transporter signature motif; other site 405535002071 Walker B; other site 405535002072 D-loop; other site 405535002073 H-loop/switch region; other site 405535002074 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 405535002075 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405535002076 substrate binding pocket [chemical binding]; other site 405535002077 membrane-bound complex binding site; other site 405535002078 hinge residues; other site 405535002079 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 405535002080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535002081 dimer interface [polypeptide binding]; other site 405535002082 conserved gate region; other site 405535002083 putative PBP binding loops; other site 405535002084 ABC-ATPase subunit interface; other site 405535002085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535002086 dimer interface [polypeptide binding]; other site 405535002087 conserved gate region; other site 405535002088 putative PBP binding loops; other site 405535002089 ABC-ATPase subunit interface; other site 405535002090 S-methylmethionine transporter; Provisional; Region: PRK11387 405535002091 OsmC-like protein; Region: OsmC; pfam02566 405535002092 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 405535002093 nucleotide binding site/active site [active] 405535002094 HIT family signature motif; other site 405535002095 catalytic residue [active] 405535002096 RNA polymerase sigma factor; Provisional; Region: PRK12542 405535002097 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535002098 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405535002099 DNA binding residues [nucleotide binding] 405535002100 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 405535002101 Predicted transcriptional regulator [Transcription]; Region: COG2378 405535002102 HTH domain; Region: HTH_11; pfam08279 405535002103 WYL domain; Region: WYL; pfam13280 405535002104 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 405535002105 RibD C-terminal domain; Region: RibD_C; cl17279 405535002106 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535002107 dimerization interface [polypeptide binding]; other site 405535002108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535002109 dimer interface [polypeptide binding]; other site 405535002110 phosphorylation site [posttranslational modification] 405535002111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535002112 ATP binding site [chemical binding]; other site 405535002113 Mg2+ binding site [ion binding]; other site 405535002114 G-X-G motif; other site 405535002115 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535002116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535002117 active site 405535002118 phosphorylation site [posttranslational modification] 405535002119 intermolecular recognition site; other site 405535002120 dimerization interface [polypeptide binding]; other site 405535002121 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535002122 DNA binding site [nucleotide binding] 405535002123 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 405535002124 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 405535002125 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 405535002126 Sulfate transporter family; Region: Sulfate_transp; pfam00916 405535002127 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 405535002128 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 405535002129 Ligand Binding Site [chemical binding]; other site 405535002130 Protein of unknown function (DUF4027); Region: DUF4027; pfam13219 405535002131 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 405535002132 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 405535002133 peptide binding site [polypeptide binding]; other site 405535002134 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 405535002135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535002136 dimer interface [polypeptide binding]; other site 405535002137 conserved gate region; other site 405535002138 putative PBP binding loops; other site 405535002139 ABC-ATPase subunit interface; other site 405535002140 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405535002141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535002142 putative PBP binding loops; other site 405535002143 ABC-ATPase subunit interface; other site 405535002144 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 405535002145 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405535002146 Walker A/P-loop; other site 405535002147 ATP binding site [chemical binding]; other site 405535002148 Q-loop/lid; other site 405535002149 ABC transporter signature motif; other site 405535002150 Walker B; other site 405535002151 D-loop; other site 405535002152 H-loop/switch region; other site 405535002153 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 405535002154 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 405535002155 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405535002156 Walker A/P-loop; other site 405535002157 ATP binding site [chemical binding]; other site 405535002158 Q-loop/lid; other site 405535002159 ABC transporter signature motif; other site 405535002160 Walker B; other site 405535002161 D-loop; other site 405535002162 H-loop/switch region; other site 405535002163 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405535002164 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 405535002165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535002166 putative substrate translocation pore; other site 405535002167 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405535002168 MarR family; Region: MarR; pfam01047 405535002169 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 405535002170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535002171 putative substrate translocation pore; other site 405535002172 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405535002173 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405535002174 DNA binding site [nucleotide binding] 405535002175 domain linker motif; other site 405535002176 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 405535002177 dimerization interface [polypeptide binding]; other site 405535002178 ligand binding site [chemical binding]; other site 405535002179 sodium binding site [ion binding]; other site 405535002180 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405535002181 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 405535002182 substrate binding site [chemical binding]; other site 405535002183 dimer interface [polypeptide binding]; other site 405535002184 ATP binding site [chemical binding]; other site 405535002185 D-ribose pyranase; Provisional; Region: PRK11797 405535002186 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 405535002187 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 405535002188 Walker A/P-loop; other site 405535002189 ATP binding site [chemical binding]; other site 405535002190 Q-loop/lid; other site 405535002191 ABC transporter signature motif; other site 405535002192 Walker B; other site 405535002193 D-loop; other site 405535002194 H-loop/switch region; other site 405535002195 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405535002196 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405535002197 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405535002198 TM-ABC transporter signature motif; other site 405535002199 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 405535002200 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 405535002201 ligand binding site [chemical binding]; other site 405535002202 dimerization interface [polypeptide binding]; other site 405535002203 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 405535002204 active site 405535002205 intersubunit interactions; other site 405535002206 catalytic residue [active] 405535002207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 405535002208 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 405535002209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535002210 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405535002211 putative substrate translocation pore; other site 405535002212 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 405535002213 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 405535002214 putative NAD(P) binding site [chemical binding]; other site 405535002215 catalytic Zn binding site [ion binding]; other site 405535002216 Ion channel; Region: Ion_trans_2; pfam07885 405535002217 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 405535002218 Zn binding site [ion binding]; other site 405535002219 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 405535002220 putative catalytic site [active] 405535002221 metal binding site A [ion binding]; metal-binding site 405535002222 phosphate binding site [ion binding]; other site 405535002223 metal binding site C [ion binding]; metal-binding site 405535002224 metal binding site B [ion binding]; metal-binding site 405535002225 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 405535002226 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 405535002227 dimer interface [polypeptide binding]; other site 405535002228 active site 405535002229 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405535002230 substrate binding site [chemical binding]; other site 405535002231 catalytic residue [active] 405535002232 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 405535002233 FAD binding domain; Region: FAD_binding_4; pfam01565 405535002234 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 405535002235 VanZ like family; Region: VanZ; pfam04892 405535002236 RDD family; Region: RDD; pfam06271 405535002237 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 405535002238 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405535002239 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405535002240 dimer interface [polypeptide binding]; other site 405535002241 putative CheW interface [polypeptide binding]; other site 405535002242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 405535002243 3D domain; Region: 3D; cl01439 405535002244 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405535002245 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535002246 non-specific DNA binding site [nucleotide binding]; other site 405535002247 salt bridge; other site 405535002248 sequence-specific DNA binding site [nucleotide binding]; other site 405535002249 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 405535002250 active site 405535002251 catalytic site [active] 405535002252 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 405535002253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535002254 putative substrate translocation pore; other site 405535002255 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405535002256 Archaeal flagella protein; Region: Arch_fla_DE; cl01322 405535002257 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 405535002258 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 405535002259 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 405535002260 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405535002261 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405535002262 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535002263 non-specific DNA binding site [nucleotide binding]; other site 405535002264 salt bridge; other site 405535002265 sequence-specific DNA binding site [nucleotide binding]; other site 405535002266 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535002267 Coenzyme A binding pocket [chemical binding]; other site 405535002268 Protein of unknown function (DUF4022); Region: DUF4022; pfam13214 405535002269 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 405535002270 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 405535002271 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 405535002272 TrkA-N domain; Region: TrkA_N; pfam02254 405535002273 TrkA-C domain; Region: TrkA_C; pfam02080 405535002274 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 405535002275 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 405535002276 Subunit III/IV interface [polypeptide binding]; other site 405535002277 Subunit I/III interface [polypeptide binding]; other site 405535002278 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 405535002279 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 405535002280 D-pathway; other site 405535002281 Putative ubiquinol binding site [chemical binding]; other site 405535002282 Low-spin heme (heme b) binding site [chemical binding]; other site 405535002283 Putative water exit pathway; other site 405535002284 Binuclear center (heme o3/CuB) [ion binding]; other site 405535002285 K-pathway; other site 405535002286 Putative proton exit pathway; other site 405535002287 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 405535002288 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 405535002289 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 405535002290 putative active site [active] 405535002291 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405535002292 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 405535002293 metal binding site [ion binding]; metal-binding site 405535002294 dimer interface [polypeptide binding]; other site 405535002295 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 405535002296 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 405535002297 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 405535002298 Na binding site [ion binding]; other site 405535002299 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405535002300 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 405535002301 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405535002302 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405535002303 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 405535002304 Nucleoside recognition; Region: Gate; pfam07670 405535002305 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 405535002306 Nucleoside recognition; Region: Gate; pfam07670 405535002307 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 405535002308 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 405535002309 G1 box; other site 405535002310 GTP/Mg2+ binding site [chemical binding]; other site 405535002311 Switch I region; other site 405535002312 G2 box; other site 405535002313 G3 box; other site 405535002314 Switch II region; other site 405535002315 G4 box; other site 405535002316 G5 box; other site 405535002317 FeoA domain; Region: FeoA; pfam04023 405535002318 phosphate binding protein; Region: ptsS_2; TIGR02136 405535002319 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 405535002320 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 405535002321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535002322 dimer interface [polypeptide binding]; other site 405535002323 conserved gate region; other site 405535002324 putative PBP binding loops; other site 405535002325 ABC-ATPase subunit interface; other site 405535002326 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 405535002327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535002328 dimer interface [polypeptide binding]; other site 405535002329 conserved gate region; other site 405535002330 putative PBP binding loops; other site 405535002331 ABC-ATPase subunit interface; other site 405535002332 AAA domain; Region: AAA_33; pfam13671 405535002333 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 405535002334 active site 405535002335 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 405535002336 FOG: CBS domain [General function prediction only]; Region: COG0517 405535002337 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 405535002338 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 405535002339 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 405535002340 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535002341 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535002342 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535002343 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405535002344 Peptidase family M23; Region: Peptidase_M23; pfam01551 405535002345 Putative transcription activator [Transcription]; Region: TenA; COG0819 405535002346 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 405535002347 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 405535002348 Walker A/P-loop; other site 405535002349 ATP binding site [chemical binding]; other site 405535002350 Q-loop/lid; other site 405535002351 ABC transporter signature motif; other site 405535002352 Walker B; other site 405535002353 D-loop; other site 405535002354 H-loop/switch region; other site 405535002355 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 405535002356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535002357 dimer interface [polypeptide binding]; other site 405535002358 conserved gate region; other site 405535002359 putative PBP binding loops; other site 405535002360 ABC-ATPase subunit interface; other site 405535002361 NMT1/THI5 like; Region: NMT1; pfam09084 405535002362 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 405535002363 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 405535002364 thiamine phosphate binding site [chemical binding]; other site 405535002365 active site 405535002366 pyrophosphate binding site [ion binding]; other site 405535002367 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 405535002368 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 405535002369 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 405535002370 thiS-thiF/thiG interaction site; other site 405535002371 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 405535002372 ThiS interaction site; other site 405535002373 putative active site [active] 405535002374 tetramer interface [polypeptide binding]; other site 405535002375 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 405535002376 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 405535002377 ATP binding site [chemical binding]; other site 405535002378 substrate interface [chemical binding]; other site 405535002379 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 405535002380 dimer interface [polypeptide binding]; other site 405535002381 substrate binding site [chemical binding]; other site 405535002382 ATP binding site [chemical binding]; other site 405535002383 ydaO/yuaA leader 405535002384 ydaO/yuaA leader 405535002385 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 405535002386 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 405535002387 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405535002388 Soluble P-type ATPase [General function prediction only]; Region: COG4087 405535002389 potassium-transporting ATPase subunit C; Provisional; Region: PRK13997 405535002390 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 405535002391 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 405535002392 Ligand Binding Site [chemical binding]; other site 405535002393 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 405535002394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535002395 putative substrate translocation pore; other site 405535002396 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405535002397 MarR family; Region: MarR; pfam01047 405535002398 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 405535002399 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 405535002400 active site 405535002401 nucleophile elbow; other site 405535002402 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405535002403 short chain dehydrogenase; Provisional; Region: PRK06701 405535002404 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 405535002405 NAD binding site [chemical binding]; other site 405535002406 metal binding site [ion binding]; metal-binding site 405535002407 active site 405535002408 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405535002409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 405535002410 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 405535002411 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405535002412 catalytic residues [active] 405535002413 putative disulfide oxidoreductase; Provisional; Region: PRK03113 405535002414 YhdB-like protein; Region: YhdB; pfam14148 405535002415 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 405535002416 Spore germination protein; Region: Spore_permease; cl17796 405535002417 potential frameshift: common BLAST hit: gi|49480302|ref|YP_035021.1| spore germination protein (GerAC) 405535002418 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405535002419 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405535002420 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405535002421 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405535002422 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 405535002423 putative FMN binding site [chemical binding]; other site 405535002424 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 405535002425 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 405535002426 EcsC protein family; Region: EcsC; pfam12787 405535002427 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 405535002428 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 405535002429 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 405535002430 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405535002431 ATP binding site [chemical binding]; other site 405535002432 putative Mg++ binding site [ion binding]; other site 405535002433 HsdM N-terminal domain; Region: HsdM_N; pfam12161 405535002434 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 405535002435 Methyltransferase domain; Region: Methyltransf_26; pfam13659 405535002436 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 405535002437 Helix-turn-helix domain; Region: HTH_17; pfam12728 405535002438 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 405535002439 DHH family; Region: DHH; pfam01368 405535002440 DHHA1 domain; Region: DHHA1; pfam02272 405535002441 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405535002442 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 405535002443 catalytic residues [active] 405535002444 catalytic nucleophile [active] 405535002445 Presynaptic Site I dimer interface [polypeptide binding]; other site 405535002446 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 405535002447 Synaptic Flat tetramer interface [polypeptide binding]; other site 405535002448 Recombinase; Region: Recombinase; pfam07508 405535002449 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 405535002450 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405535002451 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535002452 non-specific DNA binding site [nucleotide binding]; other site 405535002453 salt bridge; other site 405535002454 sequence-specific DNA binding site [nucleotide binding]; other site 405535002455 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405535002456 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 405535002457 catalytic residues [active] 405535002458 catalytic nucleophile [active] 405535002459 Recombinase; Region: Recombinase; pfam07508 405535002460 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405535002461 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 405535002462 catalytic residues [active] 405535002463 catalytic nucleophile [active] 405535002464 Recombinase; Region: Recombinase; pfam07508 405535002465 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 405535002466 SpoVR like protein; Region: SpoVR; pfam04293 405535002467 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 405535002468 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405535002469 ATP binding site [chemical binding]; other site 405535002470 putative Mg++ binding site [ion binding]; other site 405535002471 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405535002472 nucleotide binding region [chemical binding]; other site 405535002473 ATP-binding site [chemical binding]; other site 405535002474 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 405535002475 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 405535002476 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 405535002477 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 405535002478 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 405535002479 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 405535002480 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 405535002481 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405535002482 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405535002483 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405535002484 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 405535002485 active site residue [active] 405535002486 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 405535002487 putative homodimer interface [polypeptide binding]; other site 405535002488 putative homotetramer interface [polypeptide binding]; other site 405535002489 putative metal binding site [ion binding]; other site 405535002490 putative homodimer-homodimer interface [polypeptide binding]; other site 405535002491 putative allosteric switch controlling residues; other site 405535002492 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 405535002493 CPxP motif; other site 405535002494 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405535002495 active site residue [active] 405535002496 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 405535002497 active site residue [active] 405535002498 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405535002499 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 405535002500 CPxP motif; other site 405535002501 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405535002502 active site residue [active] 405535002503 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405535002504 active site residue [active] 405535002505 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 405535002506 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405535002507 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 405535002508 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 405535002509 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 405535002510 NADP binding site [chemical binding]; other site 405535002511 dimer interface [polypeptide binding]; other site 405535002512 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 405535002513 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 405535002514 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 405535002515 PhoU domain; Region: PhoU; pfam01895 405535002516 PhoU domain; Region: PhoU; pfam01895 405535002517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535002518 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405535002519 putative substrate translocation pore; other site 405535002520 Uncharacterized conserved protein [Function unknown]; Region: COG3589 405535002521 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 405535002522 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 405535002523 HTH domain; Region: HTH_11; pfam08279 405535002524 Mga helix-turn-helix domain; Region: Mga; pfam05043 405535002525 PRD domain; Region: PRD; pfam00874 405535002526 PRD domain; Region: PRD; pfam00874 405535002527 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 405535002528 active site 405535002529 P-loop; other site 405535002530 phosphorylation site [posttranslational modification] 405535002531 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 405535002532 active site 405535002533 phosphorylation site [posttranslational modification] 405535002534 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 405535002535 active site 405535002536 methionine cluster; other site 405535002537 phosphorylation site [posttranslational modification] 405535002538 metal binding site [ion binding]; metal-binding site 405535002539 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 405535002540 potential frameshift: common BLAST hit: gi|49480212|ref|YP_035047.1| PTS system, cellobiose-specific IIC component 405535002541 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 405535002542 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 405535002543 Uncharacterized conserved protein [Function unknown]; Region: COG3589 405535002544 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 405535002545 HEAT repeats; Region: HEAT_2; pfam13646 405535002546 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535002547 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535002548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 405535002549 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 405535002550 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405535002551 FtsX-like permease family; Region: FtsX; pfam02687 405535002552 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405535002553 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405535002554 Walker A/P-loop; other site 405535002555 ATP binding site [chemical binding]; other site 405535002556 Q-loop/lid; other site 405535002557 ABC transporter signature motif; other site 405535002558 Walker B; other site 405535002559 D-loop; other site 405535002560 H-loop/switch region; other site 405535002561 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 405535002562 HlyD family secretion protein; Region: HlyD_3; pfam13437 405535002563 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 405535002564 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 405535002565 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405535002566 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405535002567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535002568 dimer interface [polypeptide binding]; other site 405535002569 conserved gate region; other site 405535002570 ABC-ATPase subunit interface; other site 405535002571 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405535002572 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 405535002573 dimanganese center [ion binding]; other site 405535002574 CotJB protein; Region: CotJB; pfam12652 405535002575 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 405535002576 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405535002577 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405535002578 active site 405535002579 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 405535002580 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 405535002581 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 405535002582 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 405535002583 putative DNA binding site [nucleotide binding]; other site 405535002584 putative homodimer interface [polypeptide binding]; other site 405535002585 yybP-ykoY leader 405535002586 Uncharacterized conserved protein [Function unknown]; Region: COG3339 405535002587 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405535002588 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405535002589 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 405535002590 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 405535002591 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405535002592 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 405535002593 active site 405535002594 metal binding site [ion binding]; metal-binding site 405535002595 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405535002596 Interdomain contacts; other site 405535002597 Cytokine receptor motif; other site 405535002598 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 405535002599 amino acid transporter; Region: 2A0306; TIGR00909 405535002600 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 405535002601 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 405535002602 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 405535002603 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 405535002604 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 405535002605 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 405535002606 putative active site [active] 405535002607 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 405535002608 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 405535002609 putative active site [active] 405535002610 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405535002611 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 405535002612 active site turn [active] 405535002613 phosphorylation site [posttranslational modification] 405535002614 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405535002615 Uncharacterized conserved protein [Function unknown]; Region: COG3589 405535002616 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 405535002617 DoxX; Region: DoxX; pfam07681 405535002618 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 405535002619 hypothetical protein; Provisional; Region: PRK06770 405535002620 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405535002621 EamA-like transporter family; Region: EamA; pfam00892 405535002622 EamA-like transporter family; Region: EamA; pfam00892 405535002623 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 405535002624 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 405535002625 AsnC family; Region: AsnC_trans_reg; pfam01037 405535002626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535002627 Coenzyme A binding pocket [chemical binding]; other site 405535002628 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405535002629 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405535002630 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535002631 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535002632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535002633 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405535002634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535002635 Predicted transcriptional regulators [Transcription]; Region: COG1733 405535002636 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535002637 putative DNA binding site [nucleotide binding]; other site 405535002638 putative Zn2+ binding site [ion binding]; other site 405535002639 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 405535002640 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405535002641 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 405535002642 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 405535002643 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 405535002644 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 405535002645 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405535002646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535002647 putative substrate translocation pore; other site 405535002648 intracellular protease, PfpI family; Region: PfpI; TIGR01382 405535002649 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 405535002650 proposed catalytic triad [active] 405535002651 conserved cys residue [active] 405535002652 hydroperoxidase II; Provisional; Region: katE; PRK11249 405535002653 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 405535002654 tetramer interface [polypeptide binding]; other site 405535002655 heme binding pocket [chemical binding]; other site 405535002656 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 405535002657 domain interactions; other site 405535002658 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 405535002659 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 405535002660 Spore germination protein; Region: Spore_permease; cl17796 405535002661 Lysine riboswitch 405535002662 glutamate racemase; Provisional; Region: PRK00865 405535002663 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 405535002664 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 405535002665 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 405535002666 tetrameric interface [polypeptide binding]; other site 405535002667 activator binding site; other site 405535002668 NADP binding site [chemical binding]; other site 405535002669 substrate binding site [chemical binding]; other site 405535002670 catalytic residues [active] 405535002671 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405535002672 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 405535002673 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535002674 Walker A/P-loop; other site 405535002675 ATP binding site [chemical binding]; other site 405535002676 Q-loop/lid; other site 405535002677 ABC transporter signature motif; other site 405535002678 Walker B; other site 405535002679 D-loop; other site 405535002680 H-loop/switch region; other site 405535002681 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405535002682 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 405535002683 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 405535002684 Walker A/P-loop; other site 405535002685 ATP binding site [chemical binding]; other site 405535002686 Q-loop/lid; other site 405535002687 ABC transporter signature motif; other site 405535002688 Walker B; other site 405535002689 D-loop; other site 405535002690 H-loop/switch region; other site 405535002691 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 405535002692 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405535002693 substrate binding pocket [chemical binding]; other site 405535002694 membrane-bound complex binding site; other site 405535002695 hinge residues; other site 405535002696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535002697 dimer interface [polypeptide binding]; other site 405535002698 conserved gate region; other site 405535002699 putative PBP binding loops; other site 405535002700 ABC-ATPase subunit interface; other site 405535002701 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405535002702 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405535002703 Walker A/P-loop; other site 405535002704 ATP binding site [chemical binding]; other site 405535002705 Q-loop/lid; other site 405535002706 ABC transporter signature motif; other site 405535002707 Walker B; other site 405535002708 D-loop; other site 405535002709 H-loop/switch region; other site 405535002710 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405535002711 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 405535002712 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 405535002713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 405535002714 hypothetical protein; Provisional; Region: PRK13676 405535002715 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 405535002716 acetolactate synthase; Reviewed; Region: PRK08617 405535002717 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 405535002718 PYR/PP interface [polypeptide binding]; other site 405535002719 dimer interface [polypeptide binding]; other site 405535002720 TPP binding site [chemical binding]; other site 405535002721 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405535002722 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 405535002723 TPP-binding site [chemical binding]; other site 405535002724 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 405535002725 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 405535002726 active site 405535002727 DNA binding site [nucleotide binding] 405535002728 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 405535002729 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405535002730 active site 405535002731 motif I; other site 405535002732 motif II; other site 405535002733 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535002734 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 405535002735 Cna protein B-type domain; Region: Cna_B; pfam05738 405535002736 Cna protein B-type domain; Region: Cna_B; pfam05738 405535002737 Cna protein B-type domain; Region: Cna_B; pfam05738 405535002738 Cna protein B-type domain; Region: Cna_B; pfam05738 405535002739 Cna protein B-type domain; Region: Cna_B; pfam05738 405535002740 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405535002741 amidase catalytic site [active] 405535002742 Zn binding residues [ion binding]; other site 405535002743 substrate binding site [chemical binding]; other site 405535002744 S-layer homology domain; Region: SLH; pfam00395 405535002745 S-layer homology domain; Region: SLH; pfam00395 405535002746 S-layer homology domain; Region: SLH; pfam00395 405535002747 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 405535002748 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 405535002749 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405535002750 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 405535002751 acyl-activating enzyme (AAE) consensus motif; other site 405535002752 acyl-activating enzyme (AAE) consensus motif; other site 405535002753 putative AMP binding site [chemical binding]; other site 405535002754 putative active site [active] 405535002755 putative CoA binding site [chemical binding]; other site 405535002756 high affinity sulphate transporter 1; Region: sulP; TIGR00815 405535002757 Sulfate transporter family; Region: Sulfate_transp; pfam00916 405535002758 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 405535002759 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 405535002760 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 405535002761 ATP binding site [chemical binding]; other site 405535002762 putative Mg++ binding site [ion binding]; other site 405535002763 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 405535002764 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405535002765 nucleotide binding region [chemical binding]; other site 405535002766 ATP-binding site [chemical binding]; other site 405535002767 stage V sporulation protein B; Region: spore_V_B; TIGR02900 405535002768 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405535002769 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 405535002770 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 405535002771 S-layer homology domain; Region: SLH; pfam00395 405535002772 S-layer homology domain; Region: SLH; pfam00395 405535002773 S-layer homology domain; Region: SLH; pfam00395 405535002774 S-layer homology domain; Region: SLH; pfam00395 405535002775 S-layer homology domain; Region: SLH; pfam00395 405535002776 S-layer homology domain; Region: SLH; pfam00395 405535002777 DHHW protein; Region: DHHW; pfam14286 405535002778 DHHW protein; Region: DHHW; pfam14286 405535002779 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 405535002780 enoyl-CoA hydratase; Provisional; Region: PRK07659 405535002781 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405535002782 substrate binding site [chemical binding]; other site 405535002783 oxyanion hole (OAH) forming residues; other site 405535002784 trimer interface [polypeptide binding]; other site 405535002785 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 405535002786 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405535002787 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 405535002788 metal binding site [ion binding]; metal-binding site 405535002789 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 405535002790 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 405535002791 putative oligomer interface [polypeptide binding]; other site 405535002792 putative active site [active] 405535002793 metal binding site [ion binding]; metal-binding site 405535002794 S-layer homology domain; Region: SLH; pfam00395 405535002795 S-layer homology domain; Region: SLH; pfam00395 405535002796 S-layer homology domain; Region: SLH; pfam00395 405535002797 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 405535002798 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405535002799 active site 405535002800 metal binding site [ion binding]; metal-binding site 405535002801 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 405535002802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535002803 S-adenosylmethionine binding site [chemical binding]; other site 405535002804 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 405535002805 proline racemase; Provisional; Region: PRK13969 405535002806 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 405535002807 ornithine cyclodeaminase; Validated; Region: PRK08618 405535002808 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 405535002809 NAD(P) binding site [chemical binding]; other site 405535002810 Yip1 domain; Region: Yip1; pfam04893 405535002811 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 405535002812 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 405535002813 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405535002814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535002815 dimer interface [polypeptide binding]; other site 405535002816 conserved gate region; other site 405535002817 putative PBP binding loops; other site 405535002818 ABC-ATPase subunit interface; other site 405535002819 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405535002820 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 405535002821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535002822 dimer interface [polypeptide binding]; other site 405535002823 conserved gate region; other site 405535002824 putative PBP binding loops; other site 405535002825 ABC-ATPase subunit interface; other site 405535002826 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 405535002827 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405535002828 Walker A/P-loop; other site 405535002829 ATP binding site [chemical binding]; other site 405535002830 Q-loop/lid; other site 405535002831 ABC transporter signature motif; other site 405535002832 Walker B; other site 405535002833 D-loop; other site 405535002834 H-loop/switch region; other site 405535002835 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 405535002836 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 405535002837 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405535002838 Walker A/P-loop; other site 405535002839 ATP binding site [chemical binding]; other site 405535002840 Q-loop/lid; other site 405535002841 ABC transporter signature motif; other site 405535002842 Walker B; other site 405535002843 D-loop; other site 405535002844 H-loop/switch region; other site 405535002845 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 405535002846 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 405535002847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535002848 putative substrate translocation pore; other site 405535002849 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 405535002850 PAS domain; Region: PAS; smart00091 405535002851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535002852 ATP binding site [chemical binding]; other site 405535002853 Mg2+ binding site [ion binding]; other site 405535002854 G-X-G motif; other site 405535002855 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 405535002856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535002857 active site 405535002858 phosphorylation site [posttranslational modification] 405535002859 intermolecular recognition site; other site 405535002860 dimerization interface [polypeptide binding]; other site 405535002861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 405535002862 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405535002863 active site 405535002864 DNA binding site [nucleotide binding] 405535002865 Int/Topo IB signature motif; other site 405535002866 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 405535002867 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 405535002868 cofactor binding site; other site 405535002869 DNA binding site [nucleotide binding] 405535002870 substrate interaction site [chemical binding]; other site 405535002871 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 405535002872 LlaJI restriction endonuclease; Region: RE_LlaJI; pfam09563 405535002873 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 405535002874 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 405535002875 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 405535002876 active site 405535002877 P-loop containing region of AAA domain; Region: AAA_29; cl17516 405535002878 AAA domain; Region: AAA_21; pfam13304 405535002879 Tic20-like protein; Region: Tic20; pfam09685 405535002880 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 405535002881 DNA binding residues [nucleotide binding] 405535002882 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405535002883 dimer interface [polypeptide binding]; other site 405535002884 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 405535002885 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 405535002886 metal binding site [ion binding]; metal-binding site 405535002887 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 405535002888 replicative DNA helicase; Provisional; Region: PRK06749 405535002889 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 405535002890 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 405535002891 Walker A motif; other site 405535002892 ATP binding site [chemical binding]; other site 405535002893 Walker B motif; other site 405535002894 DNA binding loops [nucleotide binding] 405535002895 Predicted transcriptional regulators [Transcription]; Region: COG1378 405535002896 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 405535002897 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 405535002898 C-terminal domain interface [polypeptide binding]; other site 405535002899 sugar binding site [chemical binding]; other site 405535002900 hypothetical protein; Provisional; Region: PRK10621 405535002901 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405535002902 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535002903 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535002904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535002905 putative substrate translocation pore; other site 405535002906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535002907 Predicted permease; Region: DUF318; cl17795 405535002908 Predicted permease; Region: DUF318; cl17795 405535002909 Predicted transcriptional regulators [Transcription]; Region: COG1695 405535002910 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405535002911 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 405535002912 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 405535002913 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 405535002914 CGNR zinc finger; Region: zf-CGNR; pfam11706 405535002915 HPP family; Region: HPP; pfam04982 405535002916 YmzC-like protein; Region: YmzC; pfam14157 405535002917 Transcriptional regulators [Transcription]; Region: MarR; COG1846 405535002918 MarR family; Region: MarR_2; pfam12802 405535002919 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 405535002920 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 405535002921 ATP synthase I chain; Region: ATP_synt_I; pfam03899 405535002922 Phosphotransferase enzyme family; Region: APH; pfam01636 405535002923 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405535002924 active site 405535002925 ATP binding site [chemical binding]; other site 405535002926 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 405535002927 VanZ like family; Region: VanZ; pfam04892 405535002928 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 405535002929 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 405535002930 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 405535002931 dihydroxyacetone kinase; Provisional; Region: PRK14479 405535002932 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 405535002933 DAK2 domain; Region: Dak2; pfam02734 405535002934 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 405535002935 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405535002936 Zn2+ binding site [ion binding]; other site 405535002937 Mg2+ binding site [ion binding]; other site 405535002938 S-layer homology domain; Region: SLH; pfam00395 405535002939 S-layer homology domain; Region: SLH; pfam00395 405535002940 S-layer homology domain; Region: SLH; pfam00395 405535002941 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 405535002942 potential frameshift: common BLAST hit: gi|118476605|ref|YP_893756.1| PadR family transcriptional regulator 405535002943 Mrr N-terminal domain; Region: Mrr_N; pfam14338 405535002944 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 405535002945 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 405535002946 Heat induced stress protein YflT; Region: YflT; pfam11181 405535002947 CsbD-like; Region: CsbD; pfam05532 405535002948 Predicted membrane protein [Function unknown]; Region: COG2261 405535002949 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 405535002950 anti sigma factor interaction site; other site 405535002951 regulatory phosphorylation site [posttranslational modification]; other site 405535002952 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 405535002953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535002954 ATP binding site [chemical binding]; other site 405535002955 Mg2+ binding site [ion binding]; other site 405535002956 G-X-G motif; other site 405535002957 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 405535002958 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535002959 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 405535002960 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405535002961 DNA binding residues [nucleotide binding] 405535002962 Ferritin-like domain; Region: Ferritin; pfam00210 405535002963 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 405535002964 dinuclear metal binding motif [ion binding]; other site 405535002965 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 405535002966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535002967 active site 405535002968 phosphorylation site [posttranslational modification] 405535002969 intermolecular recognition site; other site 405535002970 dimerization interface [polypeptide binding]; other site 405535002971 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 405535002972 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 405535002973 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 405535002974 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 405535002975 CHASE3 domain; Region: CHASE3; pfam05227 405535002976 GAF domain; Region: GAF; pfam01590 405535002977 GAF domain; Region: GAF_2; pfam13185 405535002978 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535002979 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535002980 dimer interface [polypeptide binding]; other site 405535002981 phosphorylation site [posttranslational modification] 405535002982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535002983 ATP binding site [chemical binding]; other site 405535002984 Mg2+ binding site [ion binding]; other site 405535002985 G-X-G motif; other site 405535002986 Response regulator receiver domain; Region: Response_reg; pfam00072 405535002987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535002988 active site 405535002989 phosphorylation site [posttranslational modification] 405535002990 intermolecular recognition site; other site 405535002991 dimerization interface [polypeptide binding]; other site 405535002992 regulatory protein interface [polypeptide binding]; other site 405535002993 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 405535002994 regulatory phosphorylation site [posttranslational modification]; other site 405535002995 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 405535002996 hypothetical protein; Provisional; Region: PRK12856 405535002997 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 405535002998 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405535002999 NADP binding site [chemical binding]; other site 405535003000 dimer interface [polypeptide binding]; other site 405535003001 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 405535003002 YhzD-like protein; Region: YhzD; pfam14120 405535003003 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 405535003004 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405535003005 active site 405535003006 metal binding site [ion binding]; metal-binding site 405535003007 DNA binding site [nucleotide binding] 405535003008 AAA domain; Region: AAA_27; pfam13514 405535003009 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535003010 Walker B; other site 405535003011 D-loop; other site 405535003012 H-loop/switch region; other site 405535003013 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 405535003014 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 405535003015 generic binding surface I; other site 405535003016 generic binding surface II; other site 405535003017 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405535003018 Zn2+ binding site [ion binding]; other site 405535003019 Mg2+ binding site [ion binding]; other site 405535003020 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 405535003021 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 405535003022 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 405535003023 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 405535003024 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405535003025 Zn binding site [ion binding]; other site 405535003026 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 405535003027 Zn binding site [ion binding]; other site 405535003028 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 405535003029 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405535003030 Zn binding site [ion binding]; other site 405535003031 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 405535003032 Zn binding site [ion binding]; other site 405535003033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535003034 binding surface 405535003035 TPR motif; other site 405535003036 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405535003037 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535003038 TPR motif; other site 405535003039 binding surface 405535003040 Transposase; Region: HTH_Tnp_1; pfam01527 405535003041 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405535003042 HTH-like domain; Region: HTH_21; pfam13276 405535003043 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 405535003044 Integrase core domain; Region: rve; pfam00665 405535003045 Integrase core domain; Region: rve_2; pfam13333 405535003046 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405535003047 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 405535003048 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 405535003049 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 405535003050 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 405535003051 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535003052 non-specific DNA binding site [nucleotide binding]; other site 405535003053 salt bridge; other site 405535003054 sequence-specific DNA binding site [nucleotide binding]; other site 405535003055 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 405535003056 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 405535003057 amphipathic channel; other site 405535003058 Asn-Pro-Ala signature motifs; other site 405535003059 glycerol kinase; Provisional; Region: glpK; PRK00047 405535003060 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 405535003061 N- and C-terminal domain interface [polypeptide binding]; other site 405535003062 active site 405535003063 MgATP binding site [chemical binding]; other site 405535003064 catalytic site [active] 405535003065 metal binding site [ion binding]; metal-binding site 405535003066 glycerol binding site [chemical binding]; other site 405535003067 homotetramer interface [polypeptide binding]; other site 405535003068 homodimer interface [polypeptide binding]; other site 405535003069 FBP binding site [chemical binding]; other site 405535003070 protein IIAGlc interface [polypeptide binding]; other site 405535003071 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 405535003072 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 405535003073 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 405535003074 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535003075 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405535003076 DNA binding residues [nucleotide binding] 405535003077 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 405535003078 Predicted transcriptional regulators [Transcription]; Region: COG1695 405535003079 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 405535003080 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405535003081 MarR family; Region: MarR; pfam01047 405535003082 DoxX-like family; Region: DoxX_2; pfam13564 405535003083 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 405535003084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535003085 putative substrate translocation pore; other site 405535003086 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 405535003087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535003088 putative substrate translocation pore; other site 405535003089 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 405535003090 Part of AAA domain; Region: AAA_19; pfam13245 405535003091 Family description; Region: UvrD_C_2; pfam13538 405535003092 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 405535003093 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 405535003094 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 405535003095 transcriptional regulator Hpr; Provisional; Region: PRK13777 405535003096 MarR family; Region: MarR; pfam01047 405535003097 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 405535003098 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 405535003099 HIT family signature motif; other site 405535003100 catalytic residue [active] 405535003101 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 405535003102 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405535003103 Walker A/P-loop; other site 405535003104 ATP binding site [chemical binding]; other site 405535003105 Q-loop/lid; other site 405535003106 ABC transporter signature motif; other site 405535003107 Walker B; other site 405535003108 D-loop; other site 405535003109 H-loop/switch region; other site 405535003110 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 405535003111 EcsC protein family; Region: EcsC; pfam12787 405535003112 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 405535003113 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 405535003114 nucleophilic elbow; other site 405535003115 catalytic triad; other site 405535003116 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 405535003117 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535003118 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535003119 Uncharacterized conserved protein [Function unknown]; Region: COG3402 405535003120 Predicted membrane protein [Function unknown]; Region: COG3428 405535003121 Bacterial PH domain; Region: DUF304; pfam03703 405535003122 Bacterial PH domain; Region: DUF304; cl01348 405535003123 Bacterial PH domain; Region: DUF304; pfam03703 405535003124 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 405535003125 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 405535003126 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 405535003127 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 405535003128 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 405535003129 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405535003130 DNA binding residues [nucleotide binding] 405535003131 drug binding residues [chemical binding]; other site 405535003132 dimer interface [polypeptide binding]; other site 405535003133 Uncharacterized conserved protein [Function unknown]; Region: COG3402 405535003134 Predicted membrane protein [Function unknown]; Region: COG3428 405535003135 Bacterial PH domain; Region: DUF304; pfam03703 405535003136 Bacterial PH domain; Region: DUF304; pfam03703 405535003137 Bacterial PH domain; Region: DUF304; pfam03703 405535003138 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 405535003139 Transglycosylase; Region: Transgly; pfam00912 405535003140 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 405535003141 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405535003142 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 405535003143 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 405535003144 substrate binding site [chemical binding]; other site 405535003145 active site 405535003146 ferrochelatase; Provisional; Region: PRK12435 405535003147 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 405535003148 C-terminal domain interface [polypeptide binding]; other site 405535003149 active site 405535003150 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 405535003151 active site 405535003152 N-terminal domain interface [polypeptide binding]; other site 405535003153 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 405535003154 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405535003155 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405535003156 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 405535003157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 405535003158 Fn3 associated; Region: Fn3_assoc; pfam13287 405535003159 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 405535003160 generic binding surface II; other site 405535003161 generic binding surface I; other site 405535003162 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 405535003163 putative active site [active] 405535003164 putative catalytic site [active] 405535003165 putative Mg binding site IVb [ion binding]; other site 405535003166 putative phosphate binding site [ion binding]; other site 405535003167 putative DNA binding site [nucleotide binding]; other site 405535003168 putative Mg binding site IVa [ion binding]; other site 405535003169 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535003170 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535003171 Predicted membrane protein [Function unknown]; Region: COG1511 405535003172 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 405535003173 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 405535003174 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 405535003175 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 405535003176 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 405535003177 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405535003178 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535003179 Coenzyme A binding pocket [chemical binding]; other site 405535003180 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405535003181 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405535003182 DNA binding site [nucleotide binding] 405535003183 domain linker motif; other site 405535003184 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 405535003185 putative dimerization interface [polypeptide binding]; other site 405535003186 putative ligand binding site [chemical binding]; other site 405535003187 YhfH-like protein; Region: YhfH; pfam14149 405535003188 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 405535003189 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 405535003190 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 405535003191 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 405535003192 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 405535003193 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 405535003194 acyl-activating enzyme (AAE) consensus motif; other site 405535003195 putative AMP binding site [chemical binding]; other site 405535003196 putative active site [active] 405535003197 putative CoA binding site [chemical binding]; other site 405535003198 rod-segment of the talin C-terminal domain; Region: talin-RS; cd12150 405535003199 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 405535003200 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 405535003201 putative active site [active] 405535003202 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405535003203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535003204 Walker A/P-loop; other site 405535003205 ATP binding site [chemical binding]; other site 405535003206 Q-loop/lid; other site 405535003207 ABC transporter signature motif; other site 405535003208 Walker B; other site 405535003209 D-loop; other site 405535003210 H-loop/switch region; other site 405535003211 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 405535003212 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 405535003213 HlyD family secretion protein; Region: HlyD_3; pfam13437 405535003214 Protein of unknown function (DUF819); Region: DUF819; cl02317 405535003215 rod-segment of the talin C-terminal domain; Region: talin-RS; cd12150 405535003216 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405535003217 heme-binding site [chemical binding]; other site 405535003218 S-layer homology domain; Region: SLH; pfam00395 405535003219 S-layer homology domain; Region: SLH; pfam00395 405535003220 S-layer homology domain; Region: SLH; pfam00395 405535003221 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 405535003222 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 405535003223 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 405535003224 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 405535003225 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 405535003226 Aureocin-like type II bacteriocin; Region: Bacteriocin_IIi; pfam11758 405535003227 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 405535003228 RHS protein; Region: RHS; pfam03527 405535003229 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 405535003230 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 405535003231 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 405535003232 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 405535003233 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405535003234 putative active site [active] 405535003235 putative metal binding site [ion binding]; other site 405535003236 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405535003237 Zn2+ binding site [ion binding]; other site 405535003238 Mg2+ binding site [ion binding]; other site 405535003239 Putative zinc-finger; Region: zf-HC2; pfam13490 405535003240 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 405535003241 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 405535003242 RNA polymerase sigma factor; Provisional; Region: PRK12541 405535003243 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535003244 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405535003245 DNA binding residues [nucleotide binding] 405535003246 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405535003247 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405535003248 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405535003249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 405535003250 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405535003251 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405535003252 active site 405535003253 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535003254 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535003255 dimer interface [polypeptide binding]; other site 405535003256 phosphorylation site [posttranslational modification] 405535003257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535003258 ATP binding site [chemical binding]; other site 405535003259 Mg2+ binding site [ion binding]; other site 405535003260 G-X-G motif; other site 405535003261 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535003262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535003263 active site 405535003264 phosphorylation site [posttranslational modification] 405535003265 intermolecular recognition site; other site 405535003266 dimerization interface [polypeptide binding]; other site 405535003267 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535003268 DNA binding site [nucleotide binding] 405535003269 CAAX protease self-immunity; Region: Abi; pfam02517 405535003270 Peptidase family M48; Region: Peptidase_M48; pfam01435 405535003271 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405535003272 EamA-like transporter family; Region: EamA; pfam00892 405535003273 EamA-like transporter family; Region: EamA; pfam00892 405535003274 S-layer homology domain; Region: SLH; pfam00395 405535003275 S-layer homology domain; Region: SLH; pfam00395 405535003276 S-layer homology domain; Region: SLH; pfam00395 405535003277 S-layer homology domain; Region: SLH; pfam00395 405535003278 S-layer homology domain; Region: SLH; pfam00395 405535003279 S-layer homology domain; Region: SLH; pfam00395 405535003280 S-layer homology domain; Region: SLH; pfam00395 405535003281 S-layer homology domain; Region: SLH; pfam00395 405535003282 S-layer homology domain; Region: SLH; pfam00395 405535003283 malate synthase A; Region: malate_syn_A; TIGR01344 405535003284 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 405535003285 active site 405535003286 isocitrate lyase; Provisional; Region: PRK15063 405535003287 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 405535003288 tetramer interface [polypeptide binding]; other site 405535003289 active site 405535003290 Mg2+/Mn2+ binding site [ion binding]; other site 405535003291 potential frameshift: common BLAST hit: gi|118476718|ref|YP_893869.1| trifolitoxin immunity protein 405535003292 Phosphotransferase enzyme family; Region: APH; pfam01636 405535003293 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405535003294 DNA-binding site [nucleotide binding]; DNA binding site 405535003295 RNA-binding motif; other site 405535003296 ComK protein; Region: ComK; pfam06338 405535003297 Uncharacterized conserved protein [Function unknown]; Region: COG0398 405535003298 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405535003299 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405535003300 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405535003301 Catalytic site [active] 405535003302 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405535003303 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 405535003304 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 405535003305 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 405535003306 Part of AAA domain; Region: AAA_19; pfam13245 405535003307 Family description; Region: UvrD_C_2; pfam13538 405535003308 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 405535003309 hypothetical protein; Provisional; Region: PRK07758 405535003310 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 405535003311 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 405535003312 Spore germination protein GerPC; Region: GerPC; pfam10737 405535003313 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 405535003314 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 405535003315 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 405535003316 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 405535003317 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 405535003318 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 405535003319 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405535003320 inhibitor-cofactor binding pocket; inhibition site 405535003321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535003322 catalytic residue [active] 405535003323 hypothetical protein; Provisional; Region: PRK13673 405535003324 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 405535003325 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 405535003326 active site 405535003327 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 405535003328 dimer interface [polypeptide binding]; other site 405535003329 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 405535003330 Ligand Binding Site [chemical binding]; other site 405535003331 Molecular Tunnel; other site 405535003332 ferrochelatase; Provisional; Region: PRK12435 405535003333 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 405535003334 C-terminal domain interface [polypeptide binding]; other site 405535003335 active site 405535003336 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 405535003337 active site 405535003338 N-terminal domain interface [polypeptide binding]; other site 405535003339 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 405535003340 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 405535003341 tetramer interface [polypeptide binding]; other site 405535003342 heme binding pocket [chemical binding]; other site 405535003343 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 405535003344 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 405535003345 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 405535003346 active site 405535003347 catalytic site [active] 405535003348 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535003349 non-specific DNA binding site [nucleotide binding]; other site 405535003350 salt bridge; other site 405535003351 sequence-specific DNA binding site [nucleotide binding]; other site 405535003352 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 405535003353 binding surface 405535003354 TPR motif; other site 405535003355 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405535003356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 405535003357 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 405535003358 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 405535003359 S1 domain; Region: S1_2; pfam13509 405535003360 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 405535003361 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 405535003362 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405535003363 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405535003364 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405535003365 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405535003366 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 405535003367 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535003368 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405535003369 active site 405535003370 motif I; other site 405535003371 motif II; other site 405535003372 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 405535003373 YjzC-like protein; Region: YjzC; pfam14168 405535003374 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 405535003375 Clp amino terminal domain; Region: Clp_N; pfam02861 405535003376 Clp amino terminal domain; Region: Clp_N; pfam02861 405535003377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535003378 Walker A motif; other site 405535003379 ATP binding site [chemical binding]; other site 405535003380 Walker B motif; other site 405535003381 arginine finger; other site 405535003382 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535003383 Walker A motif; other site 405535003384 ATP binding site [chemical binding]; other site 405535003385 Walker B motif; other site 405535003386 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 405535003387 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 405535003388 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 405535003389 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 405535003390 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 405535003391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405535003392 NAD(P) binding site [chemical binding]; other site 405535003393 active site 405535003394 ComZ; Region: ComZ; pfam10815 405535003395 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 405535003396 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 405535003397 dimer interface [polypeptide binding]; other site 405535003398 active site 405535003399 CoA binding pocket [chemical binding]; other site 405535003400 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 405535003401 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 405535003402 dimer interface [polypeptide binding]; other site 405535003403 active site 405535003404 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 405535003405 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 405535003406 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 405535003407 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 405535003408 active site 405535003409 HIGH motif; other site 405535003410 dimer interface [polypeptide binding]; other site 405535003411 KMSKS motif; other site 405535003412 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 405535003413 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405535003414 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405535003415 peptide binding site [polypeptide binding]; other site 405535003416 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405535003417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535003418 dimer interface [polypeptide binding]; other site 405535003419 conserved gate region; other site 405535003420 putative PBP binding loops; other site 405535003421 ABC-ATPase subunit interface; other site 405535003422 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405535003423 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 405535003424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535003425 dimer interface [polypeptide binding]; other site 405535003426 conserved gate region; other site 405535003427 putative PBP binding loops; other site 405535003428 ABC-ATPase subunit interface; other site 405535003429 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 405535003430 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405535003431 Walker A/P-loop; other site 405535003432 ATP binding site [chemical binding]; other site 405535003433 Q-loop/lid; other site 405535003434 ABC transporter signature motif; other site 405535003435 Walker B; other site 405535003436 D-loop; other site 405535003437 H-loop/switch region; other site 405535003438 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405535003439 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 405535003440 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405535003441 Walker A/P-loop; other site 405535003442 ATP binding site [chemical binding]; other site 405535003443 Q-loop/lid; other site 405535003444 ABC transporter signature motif; other site 405535003445 Walker B; other site 405535003446 D-loop; other site 405535003447 H-loop/switch region; other site 405535003448 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405535003449 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 405535003450 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 405535003451 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405535003452 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405535003453 peptide binding site [polypeptide binding]; other site 405535003454 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 405535003455 ArsC family; Region: ArsC; pfam03960 405535003456 putative catalytic residues [active] 405535003457 thiol/disulfide switch; other site 405535003458 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 405535003459 adaptor protein; Provisional; Region: PRK02315 405535003460 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 405535003461 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 405535003462 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405535003463 putative active site [active] 405535003464 catalytic site [active] 405535003465 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 405535003466 putative active site [active] 405535003467 catalytic site [active] 405535003468 Competence protein CoiA-like family; Region: CoiA; cl11541 405535003469 oligoendopeptidase F; Region: pepF; TIGR00181 405535003470 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 405535003471 active site 405535003472 Zn binding site [ion binding]; other site 405535003473 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 405535003474 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 405535003475 catalytic residues [active] 405535003476 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 405535003477 apolar tunnel; other site 405535003478 heme binding site [chemical binding]; other site 405535003479 dimerization interface [polypeptide binding]; other site 405535003480 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 405535003481 putative active site [active] 405535003482 putative metal binding residues [ion binding]; other site 405535003483 signature motif; other site 405535003484 putative triphosphate binding site [ion binding]; other site 405535003485 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 405535003486 synthetase active site [active] 405535003487 NTP binding site [chemical binding]; other site 405535003488 metal binding site [ion binding]; metal-binding site 405535003489 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 405535003490 ATP-NAD kinase; Region: NAD_kinase; pfam01513 405535003491 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 405535003492 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 405535003493 active site 405535003494 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 405535003495 trimer interface [polypeptide binding]; other site 405535003496 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 405535003497 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 405535003498 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 405535003499 active site 405535003500 metal binding site [ion binding]; metal-binding site 405535003501 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 405535003502 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 405535003503 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 405535003504 active site 405535003505 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405535003506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535003507 S-adenosylmethionine binding site [chemical binding]; other site 405535003508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 405535003509 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 405535003510 putative metal binding site; other site 405535003511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535003512 binding surface 405535003513 TPR motif; other site 405535003514 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405535003515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535003516 S-adenosylmethionine binding site [chemical binding]; other site 405535003517 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 405535003518 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 405535003519 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405535003520 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 405535003521 active site 405535003522 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 405535003523 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 405535003524 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 405535003525 NAD binding site [chemical binding]; other site 405535003526 substrate binding site [chemical binding]; other site 405535003527 homodimer interface [polypeptide binding]; other site 405535003528 active site 405535003529 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 405535003530 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 405535003531 NADP binding site [chemical binding]; other site 405535003532 active site 405535003533 putative substrate binding site [chemical binding]; other site 405535003534 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 405535003535 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 405535003536 NAD binding site [chemical binding]; other site 405535003537 homotetramer interface [polypeptide binding]; other site 405535003538 homodimer interface [polypeptide binding]; other site 405535003539 substrate binding site [chemical binding]; other site 405535003540 active site 405535003541 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 405535003542 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 405535003543 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 405535003544 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 405535003545 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 405535003546 Part of AAA domain; Region: AAA_19; pfam13245 405535003547 Family description; Region: UvrD_C_2; pfam13538 405535003548 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 405535003549 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535003550 Coenzyme A binding pocket [chemical binding]; other site 405535003551 hypothetical protein; Provisional; Region: PRK13679 405535003552 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 405535003553 Putative esterase; Region: Esterase; pfam00756 405535003554 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 405535003555 EamA-like transporter family; Region: EamA; pfam00892 405535003556 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405535003557 EamA-like transporter family; Region: EamA; pfam00892 405535003558 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 405535003559 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 405535003560 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 405535003561 Na binding site [ion binding]; other site 405535003562 anthranilate synthase component I; Provisional; Region: PRK13570 405535003563 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 405535003564 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 405535003565 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 405535003566 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 405535003567 glutamine binding [chemical binding]; other site 405535003568 catalytic triad [active] 405535003569 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 405535003570 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 405535003571 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 405535003572 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 405535003573 active site 405535003574 ribulose/triose binding site [chemical binding]; other site 405535003575 phosphate binding site [ion binding]; other site 405535003576 substrate (anthranilate) binding pocket [chemical binding]; other site 405535003577 product (indole) binding pocket [chemical binding]; other site 405535003578 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 405535003579 active site 405535003580 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 405535003581 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 405535003582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535003583 catalytic residue [active] 405535003584 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 405535003585 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 405535003586 substrate binding site [chemical binding]; other site 405535003587 active site 405535003588 catalytic residues [active] 405535003589 heterodimer interface [polypeptide binding]; other site 405535003590 Protein of unknown function (DUF4029); Region: DUF4029; pfam13221 405535003591 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 405535003592 L-lactate permease; Region: Lactate_perm; cl00701 405535003593 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 405535003594 RNA polymerase factor sigma-70; Validated; Region: PRK06811 405535003595 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535003596 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405535003597 DNA binding residues [nucleotide binding] 405535003598 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 405535003599 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 405535003600 YARHG domain; Region: YARHG; pfam13308 405535003601 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405535003602 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 405535003603 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405535003604 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405535003605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535003606 Coenzyme A binding pocket [chemical binding]; other site 405535003607 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 405535003608 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 405535003609 NADPH bind site [chemical binding]; other site 405535003610 putative FMN binding site [chemical binding]; other site 405535003611 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 405535003612 putative FMN binding site [chemical binding]; other site 405535003613 NADPH bind site [chemical binding]; other site 405535003614 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 405535003615 YcaO-like family; Region: YcaO; pfam02624 405535003616 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 405535003617 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 405535003618 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 405535003619 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 405535003620 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405535003621 E3 interaction surface; other site 405535003622 lipoyl attachment site [posttranslational modification]; other site 405535003623 e3 binding domain; Region: E3_binding; pfam02817 405535003624 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 405535003625 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 405535003626 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 405535003627 TPP-binding site [chemical binding]; other site 405535003628 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 405535003629 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535003630 salt bridge; other site 405535003631 non-specific DNA binding site [nucleotide binding]; other site 405535003632 sequence-specific DNA binding site [nucleotide binding]; other site 405535003633 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 405535003634 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 405535003635 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 405535003636 Helix-turn-helix domain; Region: HTH_36; pfam13730 405535003637 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 405535003638 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405535003639 active site 405535003640 DNA binding site [nucleotide binding] 405535003641 Int/Topo IB signature motif; other site 405535003642 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 405535003643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535003644 S-adenosylmethionine binding site [chemical binding]; other site 405535003645 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 405535003646 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405535003647 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 405535003648 HTH-like domain; Region: HTH_21; pfam13276 405535003649 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 405535003650 Integrase core domain; Region: rve; pfam00665 405535003651 Integrase core domain; Region: rve_2; pfam13333 405535003652 Transposase; Region: HTH_Tnp_1; pfam01527 405535003653 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405535003654 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 405535003655 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405535003656 Catalytic site [active] 405535003657 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 405535003658 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 405535003659 Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389 405535003660 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405535003661 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535003662 non-specific DNA binding site [nucleotide binding]; other site 405535003663 salt bridge; other site 405535003664 sequence-specific DNA binding site [nucleotide binding]; other site 405535003665 Anti-repressor SinI; Region: SinI; pfam08671 405535003666 Anti-repressor SinI; Region: SinI; pfam08671 405535003667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 405535003668 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 405535003669 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 405535003670 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 405535003671 NAD(P) binding site [chemical binding]; other site 405535003672 catalytic residues [active] 405535003673 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 405535003674 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 405535003675 Walker A/P-loop; other site 405535003676 ATP binding site [chemical binding]; other site 405535003677 Q-loop/lid; other site 405535003678 ABC transporter signature motif; other site 405535003679 Walker B; other site 405535003680 D-loop; other site 405535003681 H-loop/switch region; other site 405535003682 TOBE domain; Region: TOBE_2; pfam08402 405535003683 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 405535003684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535003685 dimer interface [polypeptide binding]; other site 405535003686 conserved gate region; other site 405535003687 putative PBP binding loops; other site 405535003688 ABC-ATPase subunit interface; other site 405535003689 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 405535003690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535003691 dimer interface [polypeptide binding]; other site 405535003692 conserved gate region; other site 405535003693 putative PBP binding loops; other site 405535003694 ABC-ATPase subunit interface; other site 405535003695 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 405535003696 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 405535003697 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 405535003698 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405535003699 active site 405535003700 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 405535003701 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 405535003702 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 405535003703 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 405535003704 active site 405535003705 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 405535003706 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 405535003707 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 405535003708 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 405535003709 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 405535003710 Cysteine-rich domain; Region: CCG; pfam02754 405535003711 Cysteine-rich domain; Region: CCG; pfam02754 405535003712 FAD binding domain; Region: FAD_binding_4; pfam01565 405535003713 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 405535003714 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 405535003715 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 405535003716 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 405535003717 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 405535003718 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 405535003719 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535003720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535003721 active site 405535003722 phosphorylation site [posttranslational modification] 405535003723 intermolecular recognition site; other site 405535003724 dimerization interface [polypeptide binding]; other site 405535003725 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535003726 DNA binding site [nucleotide binding] 405535003727 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 405535003728 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535003729 dimerization interface [polypeptide binding]; other site 405535003730 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535003731 dimer interface [polypeptide binding]; other site 405535003732 phosphorylation site [posttranslational modification] 405535003733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535003734 ATP binding site [chemical binding]; other site 405535003735 Mg2+ binding site [ion binding]; other site 405535003736 G-X-G motif; other site 405535003737 Transcriptional regulators [Transcription]; Region: FadR; COG2186 405535003738 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535003739 DNA-binding site [nucleotide binding]; DNA binding site 405535003740 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 405535003741 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 405535003742 Cysteine-rich domain; Region: CCG; pfam02754 405535003743 Cysteine-rich domain; Region: CCG; pfam02754 405535003744 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 405535003745 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 405535003746 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 405535003747 Uncharacterized conserved protein [Function unknown]; Region: COG1556 405535003748 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 405535003749 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 405535003750 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 405535003751 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 405535003752 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 405535003753 yybP-ykoY leader 405535003754 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 405535003755 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 405535003756 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405535003757 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 405535003758 dimer interaction site [polypeptide binding]; other site 405535003759 substrate-binding tunnel; other site 405535003760 active site 405535003761 catalytic site [active] 405535003762 substrate binding site [chemical binding]; other site 405535003763 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 405535003764 poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719 405535003765 Predicted transcriptional regulators [Transcription]; Region: COG1695 405535003766 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 405535003767 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 405535003768 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 405535003769 NAD(P) binding site [chemical binding]; other site 405535003770 homotetramer interface [polypeptide binding]; other site 405535003771 homodimer interface [polypeptide binding]; other site 405535003772 active site 405535003773 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 405535003774 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 405535003775 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 405535003776 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 405535003777 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 405535003778 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 405535003779 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 405535003780 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 405535003781 putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261 405535003782 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 405535003783 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 405535003784 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535003785 Walker A/P-loop; other site 405535003786 ATP binding site [chemical binding]; other site 405535003787 Q-loop/lid; other site 405535003788 ABC transporter signature motif; other site 405535003789 Walker B; other site 405535003790 D-loop; other site 405535003791 H-loop/switch region; other site 405535003792 TOBE domain; Region: TOBE_2; pfam08402 405535003793 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 405535003794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535003795 dimer interface [polypeptide binding]; other site 405535003796 conserved gate region; other site 405535003797 putative PBP binding loops; other site 405535003798 ABC-ATPase subunit interface; other site 405535003799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535003800 dimer interface [polypeptide binding]; other site 405535003801 conserved gate region; other site 405535003802 putative PBP binding loops; other site 405535003803 ABC-ATPase subunit interface; other site 405535003804 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 405535003805 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535003806 motif II; other site 405535003807 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 405535003808 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405535003809 catalytic residue [active] 405535003810 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 405535003811 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 405535003812 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 405535003813 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405535003814 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405535003815 heme-binding site [chemical binding]; other site 405535003816 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405535003817 Leucine rich repeat; Region: LRR_8; pfam13855 405535003818 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 405535003819 Leucine rich repeat; Region: LRR_8; pfam13855 405535003820 Leucine-rich repeats; other site 405535003821 Substrate binding site [chemical binding]; other site 405535003822 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405535003823 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405535003824 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405535003825 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405535003826 S-layer homology domain; Region: SLH; pfam00395 405535003827 S-layer homology domain; Region: SLH; pfam00395 405535003828 S-layer homology domain; Region: SLH; pfam00395 405535003829 hypothetical protein; Validated; Region: PRK06755 405535003830 intersubunit interface [polypeptide binding]; other site 405535003831 active site 405535003832 Zn2+ binding site [ion binding]; other site 405535003833 FOG: CBS domain [General function prediction only]; Region: COG0517 405535003834 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 405535003835 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 405535003836 NodB motif; other site 405535003837 putative active site [active] 405535003838 putative catalytic site [active] 405535003839 Zn binding site [ion binding]; other site 405535003840 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 405535003841 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 405535003842 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535003843 dimer interface [polypeptide binding]; other site 405535003844 phosphorylation site [posttranslational modification] 405535003845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535003846 ATP binding site [chemical binding]; other site 405535003847 Mg2+ binding site [ion binding]; other site 405535003848 G-X-G motif; other site 405535003849 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405535003850 MarR family; Region: MarR; pfam01047 405535003851 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 405535003852 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 405535003853 active site 405535003854 Zn binding site [ion binding]; other site 405535003855 DinB superfamily; Region: DinB_2; pfam12867 405535003856 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 405535003857 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535003858 dimer interface [polypeptide binding]; other site 405535003859 phosphorylation site [posttranslational modification] 405535003860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535003861 ATP binding site [chemical binding]; other site 405535003862 Mg2+ binding site [ion binding]; other site 405535003863 G-X-G motif; other site 405535003864 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 405535003865 Ligand Binding Site [chemical binding]; other site 405535003866 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 405535003867 active site 405535003868 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 405535003869 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 405535003870 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 405535003871 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 405535003872 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 405535003873 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535003874 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405535003875 Coenzyme A binding pocket [chemical binding]; other site 405535003876 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 405535003877 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 405535003878 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 405535003879 N-terminal catalytic domain of GIY-YIG intron endonuclease I-TevI, I-BmoI, I-BanI, I-BthII and similar proteins; Region: GIY-YIG_HE_I-TevI_like; cd10437 405535003880 group I intron endonuclease; Region: grpIintron_endo; TIGR01453 405535003881 GIY-YIG motif/motif A; other site 405535003882 putative active site [active] 405535003883 catalytic site [active] 405535003884 putative metal binding site [ion binding]; other site 405535003885 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508 405535003886 DNA binding site [nucleotide binding] 405535003887 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 405535003888 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 405535003889 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 405535003890 dimer interface [polypeptide binding]; other site 405535003891 putative radical transfer pathway; other site 405535003892 diiron center [ion binding]; other site 405535003893 tyrosyl radical; other site 405535003894 Predicted transcriptional regulators [Transcription]; Region: COG1725 405535003895 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535003896 DNA-binding site [nucleotide binding]; DNA binding site 405535003897 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405535003898 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405535003899 Walker A/P-loop; other site 405535003900 ATP binding site [chemical binding]; other site 405535003901 Q-loop/lid; other site 405535003902 ABC transporter signature motif; other site 405535003903 Walker B; other site 405535003904 D-loop; other site 405535003905 H-loop/switch region; other site 405535003906 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405535003907 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535003908 Walker A/P-loop; other site 405535003909 ATP binding site [chemical binding]; other site 405535003910 Q-loop/lid; other site 405535003911 ABC transporter signature motif; other site 405535003912 Walker B; other site 405535003913 D-loop; other site 405535003914 H-loop/switch region; other site 405535003915 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 405535003916 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405535003917 CAAX protease self-immunity; Region: Abi; pfam02517 405535003918 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 405535003919 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 405535003920 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 405535003921 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535003922 putative DNA binding site [nucleotide binding]; other site 405535003923 putative Zn2+ binding site [ion binding]; other site 405535003924 AsnC family; Region: AsnC_trans_reg; pfam01037 405535003925 Uncharacterized conserved protein [Function unknown]; Region: COG2128 405535003926 Isochorismatase family; Region: Isochorismatase; pfam00857 405535003927 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 405535003928 catalytic triad [active] 405535003929 conserved cis-peptide bond; other site 405535003930 SseB protein; Region: SseB; cl06279 405535003931 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 405535003932 dimer interface [polypeptide binding]; other site 405535003933 catalytic triad [active] 405535003934 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 405535003935 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 405535003936 FMN binding site [chemical binding]; other site 405535003937 substrate binding site [chemical binding]; other site 405535003938 putative catalytic residue [active] 405535003939 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 405535003940 DltD N-terminal region; Region: DltD_N; pfam04915 405535003941 DltD central region; Region: DltD_M; pfam04918 405535003942 DltD C-terminal region; Region: DltD_C; pfam04914 405535003943 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 405535003944 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 405535003945 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 405535003946 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 405535003947 acyl-activating enzyme (AAE) consensus motif; other site 405535003948 AMP binding site [chemical binding]; other site 405535003949 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 405535003950 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405535003951 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 405535003952 metal binding site [ion binding]; metal-binding site 405535003953 dimer interface [polypeptide binding]; other site 405535003954 flavodoxin; Provisional; Region: PRK06756 405535003955 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 405535003956 Phosphotransferase enzyme family; Region: APH; pfam01636 405535003957 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405535003958 active site 405535003959 substrate binding site [chemical binding]; other site 405535003960 ATP binding site [chemical binding]; other site 405535003961 Wnt and FGF inhibitory regulator; Region: Shisa; pfam13908 405535003962 multidrug efflux protein; Reviewed; Region: PRK01766 405535003963 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 405535003964 cation binding site [ion binding]; other site 405535003965 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 405535003966 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405535003967 catalytic residues [active] 405535003968 Regulatory protein YrvL; Region: YrvL; pfam14184 405535003969 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405535003970 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 405535003971 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405535003972 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 405535003973 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 405535003974 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 405535003975 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 405535003976 hypothetical protein; Provisional; Region: PRK03094 405535003977 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 405535003978 flavin-containing monooxygenase FMO GS-OX; Region: PLN02172 405535003979 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 405535003980 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 405535003981 homodimer interface [polypeptide binding]; other site 405535003982 substrate-cofactor binding pocket; other site 405535003983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535003984 catalytic residue [active] 405535003985 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 405535003986 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 405535003987 PYR/PP interface [polypeptide binding]; other site 405535003988 dimer interface [polypeptide binding]; other site 405535003989 TPP binding site [chemical binding]; other site 405535003990 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405535003991 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 405535003992 TPP-binding site [chemical binding]; other site 405535003993 dimer interface [polypeptide binding]; other site 405535003994 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 405535003995 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 405535003996 putative valine binding site [chemical binding]; other site 405535003997 dimer interface [polypeptide binding]; other site 405535003998 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 405535003999 ketol-acid reductoisomerase; Provisional; Region: PRK05479 405535004000 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 405535004001 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 405535004002 2-isopropylmalate synthase; Validated; Region: PRK00915 405535004003 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 405535004004 active site 405535004005 catalytic residues [active] 405535004006 metal binding site [ion binding]; metal-binding site 405535004007 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 405535004008 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 405535004009 tartrate dehydrogenase; Region: TTC; TIGR02089 405535004010 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 405535004011 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 405535004012 substrate binding site [chemical binding]; other site 405535004013 ligand binding site [chemical binding]; other site 405535004014 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 405535004015 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 405535004016 substrate binding site [chemical binding]; other site 405535004017 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 405535004018 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 405535004019 dimer interface [polypeptide binding]; other site 405535004020 motif 1; other site 405535004021 active site 405535004022 motif 2; other site 405535004023 motif 3; other site 405535004024 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 405535004025 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 405535004026 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 405535004027 histidinol dehydrogenase; Region: hisD; TIGR00069 405535004028 NAD binding site [chemical binding]; other site 405535004029 dimerization interface [polypeptide binding]; other site 405535004030 product binding site; other site 405535004031 substrate binding site [chemical binding]; other site 405535004032 zinc binding site [ion binding]; other site 405535004033 catalytic residues [active] 405535004034 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 405535004035 putative active site pocket [active] 405535004036 4-fold oligomerization interface [polypeptide binding]; other site 405535004037 metal binding residues [ion binding]; metal-binding site 405535004038 3-fold/trimer interface [polypeptide binding]; other site 405535004039 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 405535004040 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 405535004041 putative active site [active] 405535004042 oxyanion strand; other site 405535004043 catalytic triad [active] 405535004044 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 405535004045 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 405535004046 catalytic residues [active] 405535004047 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 405535004048 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 405535004049 substrate binding site [chemical binding]; other site 405535004050 glutamase interaction surface [polypeptide binding]; other site 405535004051 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 405535004052 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 405535004053 metal binding site [ion binding]; metal-binding site 405535004054 histidinol-phosphatase; Validated; Region: PRK06740 405535004055 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 405535004056 dimer interface [polypeptide binding]; other site 405535004057 active site 405535004058 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 405535004059 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 405535004060 putative ligand binding site [chemical binding]; other site 405535004061 putative NAD binding site [chemical binding]; other site 405535004062 catalytic site [active] 405535004063 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 405535004064 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 405535004065 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 405535004066 Sulfatase; Region: Sulfatase; pfam00884 405535004067 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 405535004068 Lysine riboswitch 405535004069 diaminopimelate decarboxylase; Region: lysA; TIGR01048 405535004070 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 405535004071 active site 405535004072 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405535004073 substrate binding site [chemical binding]; other site 405535004074 catalytic residues [active] 405535004075 dimer interface [polypeptide binding]; other site 405535004076 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 405535004077 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 405535004078 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 405535004079 Active Sites [active] 405535004080 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 405535004081 ATP-sulfurylase; Region: ATPS; cd00517 405535004082 active site 405535004083 HXXH motif; other site 405535004084 flexible loop; other site 405535004085 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 405535004086 ligand-binding site [chemical binding]; other site 405535004087 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 405535004088 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 405535004089 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 405535004090 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 405535004091 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 405535004092 diphthine synthase; Region: dph5; TIGR00522 405535004093 active site 405535004094 SAM binding site [chemical binding]; other site 405535004095 homodimer interface [polypeptide binding]; other site 405535004096 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 405535004097 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 405535004098 putative active site [active] 405535004099 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 405535004100 putative active site [active] 405535004101 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 405535004102 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 405535004103 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 405535004104 Na2 binding site [ion binding]; other site 405535004105 putative substrate binding site 1 [chemical binding]; other site 405535004106 Na binding site 1 [ion binding]; other site 405535004107 putative substrate binding site 2 [chemical binding]; other site 405535004108 Transposase; Region: HTH_Tnp_1; cl17663 405535004109 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405535004110 HTH-like domain; Region: HTH_21; pfam13276 405535004111 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 405535004112 Integrase core domain; Region: rve; pfam00665 405535004113 Integrase core domain; Region: rve_2; pfam13333 405535004114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 405535004115 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405535004116 Peptidase family M23; Region: Peptidase_M23; pfam01551 405535004117 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405535004118 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 405535004119 Protein of unknown function (DUF402); Region: DUF402; cl00979 405535004120 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 405535004121 Vpu protein; Region: Vpu; pfam00558 405535004122 PspA/IM30 family; Region: PspA_IM30; pfam04012 405535004123 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 405535004124 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405535004125 Histidine kinase; Region: HisKA_3; pfam07730 405535004126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535004127 ATP binding site [chemical binding]; other site 405535004128 Mg2+ binding site [ion binding]; other site 405535004129 G-X-G motif; other site 405535004130 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405535004131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535004132 active site 405535004133 phosphorylation site [posttranslational modification] 405535004134 intermolecular recognition site; other site 405535004135 dimerization interface [polypeptide binding]; other site 405535004136 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405535004137 DNA binding residues [nucleotide binding] 405535004138 dimerization interface [polypeptide binding]; other site 405535004139 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405535004140 E3 interaction surface; other site 405535004141 lipoyl attachment site [posttranslational modification]; other site 405535004142 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405535004143 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405535004144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535004145 S-adenosylmethionine binding site [chemical binding]; other site 405535004146 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 405535004147 Peptidase family M50; Region: Peptidase_M50; pfam02163 405535004148 active site 405535004149 putative substrate binding region [chemical binding]; other site 405535004150 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 405535004151 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 405535004152 heme-binding site [chemical binding]; other site 405535004153 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 405535004154 FAD binding pocket [chemical binding]; other site 405535004155 FAD binding motif [chemical binding]; other site 405535004156 phosphate binding motif [ion binding]; other site 405535004157 beta-alpha-beta structure motif; other site 405535004158 NAD binding pocket [chemical binding]; other site 405535004159 Heme binding pocket [chemical binding]; other site 405535004160 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 405535004161 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405535004162 ligand binding site [chemical binding]; other site 405535004163 flexible hinge region; other site 405535004164 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 405535004165 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405535004166 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405535004167 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 405535004168 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 405535004169 Transglycosylase; Region: Transgly; pfam00912 405535004170 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 405535004171 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405535004172 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 405535004173 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405535004174 putative active site [active] 405535004175 heme pocket [chemical binding]; other site 405535004176 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535004177 dimer interface [polypeptide binding]; other site 405535004178 phosphorylation site [posttranslational modification] 405535004179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535004180 ATP binding site [chemical binding]; other site 405535004181 Mg2+ binding site [ion binding]; other site 405535004182 G-X-G motif; other site 405535004183 Protein of unknown function DUF72; Region: DUF72; pfam01904 405535004184 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 405535004185 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405535004186 active site 405535004187 DNA binding site [nucleotide binding] 405535004188 Int/Topo IB signature motif; other site 405535004189 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535004190 dimerization interface [polypeptide binding]; other site 405535004191 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535004192 dimer interface [polypeptide binding]; other site 405535004193 phosphorylation site [posttranslational modification] 405535004194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535004195 ATP binding site [chemical binding]; other site 405535004196 Mg2+ binding site [ion binding]; other site 405535004197 G-X-G motif; other site 405535004198 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 405535004199 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 405535004200 Probable transposase; Region: OrfB_IS605; pfam01385 405535004201 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405535004202 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 405535004203 Predicted integral membrane protein [Function unknown]; Region: COG0392 405535004204 Uncharacterized conserved protein [Function unknown]; Region: COG2898 405535004205 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 405535004206 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 405535004207 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 405535004208 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 405535004209 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 405535004210 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405535004211 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 405535004212 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 405535004213 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 405535004214 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 405535004215 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405535004216 RNA binding surface [nucleotide binding]; other site 405535004217 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 405535004218 active site 405535004219 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 405535004220 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 405535004221 catalytic residues [active] 405535004222 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 405535004223 ResB-like family; Region: ResB; pfam05140 405535004224 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 405535004225 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 405535004226 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535004227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535004228 active site 405535004229 phosphorylation site [posttranslational modification] 405535004230 intermolecular recognition site; other site 405535004231 dimerization interface [polypeptide binding]; other site 405535004232 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535004233 DNA binding site [nucleotide binding] 405535004234 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 405535004235 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535004236 dimerization interface [polypeptide binding]; other site 405535004237 PAS domain; Region: PAS; smart00091 405535004238 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535004239 dimer interface [polypeptide binding]; other site 405535004240 phosphorylation site [posttranslational modification] 405535004241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535004242 ATP binding site [chemical binding]; other site 405535004243 Mg2+ binding site [ion binding]; other site 405535004244 G-X-G motif; other site 405535004245 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 405535004246 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405535004247 Peptidase family M23; Region: Peptidase_M23; pfam01551 405535004248 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405535004249 Predicted membrane protein [Function unknown]; Region: COG3601 405535004250 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 405535004251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 405535004252 DEAD-like helicases superfamily; Region: DEXDc; smart00487 405535004253 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405535004254 ATP binding site [chemical binding]; other site 405535004255 putative Mg++ binding site [ion binding]; other site 405535004256 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405535004257 nucleotide binding region [chemical binding]; other site 405535004258 ATP-binding site [chemical binding]; other site 405535004259 CAAX protease self-immunity; Region: Abi; pfam02517 405535004260 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405535004261 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 405535004262 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405535004263 putative active site [active] 405535004264 putative metal binding site [ion binding]; other site 405535004265 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405535004266 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 405535004267 DNA binding residues [nucleotide binding] 405535004268 B12 binding domain; Region: B12-binding_2; pfam02607 405535004269 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 405535004270 adaptor protein; Provisional; Region: PRK02899 405535004271 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 405535004272 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 405535004273 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 405535004274 NAD(P) binding site [chemical binding]; other site 405535004275 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 405535004276 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405535004277 amidase catalytic site [active] 405535004278 Zn binding residues [ion binding]; other site 405535004279 substrate binding site [chemical binding]; other site 405535004280 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 405535004281 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 405535004282 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405535004283 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 405535004284 active site 405535004285 homodimer interface [polypeptide binding]; other site 405535004286 homotetramer interface [polypeptide binding]; other site 405535004287 cytidylate kinase; Provisional; Region: cmk; PRK00023 405535004288 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 405535004289 CMP-binding site; other site 405535004290 The sites determining sugar specificity; other site 405535004291 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 405535004292 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 405535004293 RNA binding site [nucleotide binding]; other site 405535004294 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 405535004295 RNA binding site [nucleotide binding]; other site 405535004296 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 405535004297 RNA binding site [nucleotide binding]; other site 405535004298 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 405535004299 RNA binding site [nucleotide binding]; other site 405535004300 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 405535004301 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 405535004302 homotetramer interface [polypeptide binding]; other site 405535004303 FMN binding site [chemical binding]; other site 405535004304 homodimer contacts [polypeptide binding]; other site 405535004305 putative active site [active] 405535004306 putative substrate binding site [chemical binding]; other site 405535004307 YpzI-like protein; Region: YpzI; pfam14140 405535004308 YIEGIA protein; Region: YIEGIA; pfam14045 405535004309 GTP-binding protein Der; Reviewed; Region: PRK00093 405535004310 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 405535004311 G1 box; other site 405535004312 GTP/Mg2+ binding site [chemical binding]; other site 405535004313 Switch I region; other site 405535004314 G2 box; other site 405535004315 Switch II region; other site 405535004316 G3 box; other site 405535004317 G4 box; other site 405535004318 G5 box; other site 405535004319 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 405535004320 G1 box; other site 405535004321 GTP/Mg2+ binding site [chemical binding]; other site 405535004322 Switch I region; other site 405535004323 G2 box; other site 405535004324 G3 box; other site 405535004325 Switch II region; other site 405535004326 G4 box; other site 405535004327 G5 box; other site 405535004328 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 405535004329 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 405535004330 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 405535004331 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 405535004332 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 405535004333 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 405535004334 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 405535004335 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 405535004336 IHF dimer interface [polypeptide binding]; other site 405535004337 IHF - DNA interface [nucleotide binding]; other site 405535004338 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 405535004339 homodecamer interface [polypeptide binding]; other site 405535004340 GTP cyclohydrolase I; Provisional; Region: PLN03044 405535004341 active site 405535004342 putative catalytic site residues [active] 405535004343 zinc binding site [ion binding]; other site 405535004344 GTP-CH-I/GFRP interaction surface; other site 405535004345 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 405535004346 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 405535004347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535004348 S-adenosylmethionine binding site [chemical binding]; other site 405535004349 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 405535004350 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 405535004351 substrate binding pocket [chemical binding]; other site 405535004352 chain length determination region; other site 405535004353 substrate-Mg2+ binding site; other site 405535004354 catalytic residues [active] 405535004355 aspartate-rich region 1; other site 405535004356 active site lid residues [active] 405535004357 aspartate-rich region 2; other site 405535004358 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 405535004359 active site 405535004360 multimer interface [polypeptide binding]; other site 405535004361 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 405535004362 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 405535004363 Tetramer interface [polypeptide binding]; other site 405535004364 active site 405535004365 FMN-binding site [chemical binding]; other site 405535004366 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 405535004367 active site 405535004368 dimer interface [polypeptide binding]; other site 405535004369 metal binding site [ion binding]; metal-binding site 405535004370 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 405535004371 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405535004372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535004373 homodimer interface [polypeptide binding]; other site 405535004374 catalytic residue [active] 405535004375 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 405535004376 TPR motif; other site 405535004377 binding surface 405535004378 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405535004379 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535004380 binding surface 405535004381 TPR motif; other site 405535004382 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 405535004383 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535004384 binding surface 405535004385 TPR motif; other site 405535004386 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405535004387 TPR repeat; Region: TPR_11; pfam13414 405535004388 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535004389 binding surface 405535004390 TPR motif; other site 405535004391 hypothetical protein; Provisional; Region: PRK03636 405535004392 UPF0302 domain; Region: UPF0302; pfam08864 405535004393 IDEAL domain; Region: IDEAL; pfam08858 405535004394 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 405535004395 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 405535004396 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 405535004397 iron-sulfur cluster [ion binding]; other site 405535004398 [2Fe-2S] cluster binding site [ion binding]; other site 405535004399 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 405535004400 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 405535004401 interchain domain interface [polypeptide binding]; other site 405535004402 intrachain domain interface; other site 405535004403 heme bH binding site [chemical binding]; other site 405535004404 Qi binding site; other site 405535004405 heme bL binding site [chemical binding]; other site 405535004406 Qo binding site; other site 405535004407 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 405535004408 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 405535004409 interchain domain interface [polypeptide binding]; other site 405535004410 intrachain domain interface; other site 405535004411 Qi binding site; other site 405535004412 Qo binding site; other site 405535004413 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 405535004414 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 405535004415 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 405535004416 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 405535004417 sporulation protein YpjB; Region: spore_ypjB; TIGR02878 405535004418 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 405535004419 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 405535004420 active site 405535004421 Fe-S cluster binding site [ion binding]; other site 405535004422 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405535004423 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405535004424 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405535004425 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405535004426 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 405535004427 homodimer interface [polypeptide binding]; other site 405535004428 metal binding site [ion binding]; metal-binding site 405535004429 dihydrodipicolinate reductase; Provisional; Region: PRK00048 405535004430 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 405535004431 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 405535004432 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 405535004433 active site 405535004434 dimer interfaces [polypeptide binding]; other site 405535004435 catalytic residues [active] 405535004436 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 405535004437 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 405535004438 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 405535004439 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 405535004440 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 405535004441 active site 405535004442 NTP binding site [chemical binding]; other site 405535004443 metal binding triad [ion binding]; metal-binding site 405535004444 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 405535004445 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 405535004446 Biotin operon repressor [Transcription]; Region: BirA; COG1654 405535004447 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 405535004448 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 405535004449 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 405535004450 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 405535004451 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 405535004452 oligomerization interface [polypeptide binding]; other site 405535004453 active site 405535004454 metal binding site [ion binding]; metal-binding site 405535004455 pantoate--beta-alanine ligase; Region: panC; TIGR00018 405535004456 Pantoate-beta-alanine ligase; Region: PanC; cd00560 405535004457 active site 405535004458 ATP-binding site [chemical binding]; other site 405535004459 pantoate-binding site; other site 405535004460 HXXH motif; other site 405535004461 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 405535004462 tetramerization interface [polypeptide binding]; other site 405535004463 active site 405535004464 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 405535004465 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 405535004466 active site 405535004467 catalytic site [active] 405535004468 substrate binding site [chemical binding]; other site 405535004469 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 405535004470 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405535004471 nucleotide binding region [chemical binding]; other site 405535004472 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 405535004473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 405535004474 aspartate aminotransferase; Provisional; Region: PRK05764 405535004475 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405535004476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535004477 homodimer interface [polypeptide binding]; other site 405535004478 catalytic residue [active] 405535004479 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 405535004480 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 405535004481 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 405535004482 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 405535004483 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 405535004484 minor groove reading motif; other site 405535004485 helix-hairpin-helix signature motif; other site 405535004486 substrate binding pocket [chemical binding]; other site 405535004487 active site 405535004488 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 405535004489 Transglycosylase; Region: Transgly; pfam00912 405535004490 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 405535004491 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 405535004492 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405535004493 Interdomain contacts; other site 405535004494 Cytokine receptor motif; other site 405535004495 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 405535004496 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 405535004497 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 405535004498 YppF-like protein; Region: YppF; pfam14178 405535004499 YppG-like protein; Region: YppG; pfam14179 405535004500 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 405535004501 hypothetical protein; Provisional; Region: PRK13660 405535004502 cell division protein GpsB; Provisional; Region: PRK14127 405535004503 DivIVA domain; Region: DivI1A_domain; TIGR03544 405535004504 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 405535004505 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 405535004506 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 405535004507 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 405535004508 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 405535004509 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 405535004510 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 405535004511 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 405535004512 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 405535004513 active site 405535004514 Zn binding site [ion binding]; other site 405535004515 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405535004516 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405535004517 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 405535004518 Phosphotransferase enzyme family; Region: APH; pfam01636 405535004519 putative active site [active] 405535004520 putative substrate binding site [chemical binding]; other site 405535004521 ATP binding site [chemical binding]; other site 405535004522 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 405535004523 active site 405535004524 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405535004525 active site 405535004526 xanthine permease; Region: pbuX; TIGR03173 405535004527 Predicted membrane protein [Function unknown]; Region: COG2311 405535004528 Protein of unknown function (DUF418); Region: DUF418; cl12135 405535004529 Protein of unknown function (DUF418); Region: DUF418; pfam04235 405535004530 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 405535004531 Dynamin family; Region: Dynamin_N; pfam00350 405535004532 G1 box; other site 405535004533 GTP/Mg2+ binding site [chemical binding]; other site 405535004534 G2 box; other site 405535004535 Switch I region; other site 405535004536 G3 box; other site 405535004537 Switch II region; other site 405535004538 G4 box; other site 405535004539 G5 box; other site 405535004540 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 405535004541 Dynamin family; Region: Dynamin_N; pfam00350 405535004542 G1 box; other site 405535004543 GTP/Mg2+ binding site [chemical binding]; other site 405535004544 G2 box; other site 405535004545 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 405535004546 G3 box; other site 405535004547 Switch II region; other site 405535004548 GTP/Mg2+ binding site [chemical binding]; other site 405535004549 G4 box; other site 405535004550 G5 box; other site 405535004551 Protein of unknown function (DUF3931); Region: DUF3931; pfam13082 405535004552 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 405535004553 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535004554 Coenzyme A binding pocket [chemical binding]; other site 405535004555 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 405535004556 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 405535004557 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 405535004558 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 405535004559 active site residue [active] 405535004560 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 405535004561 active site residue [active] 405535004562 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 405535004563 Predicted membrane protein [Function unknown]; Region: COG3766 405535004564 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 405535004565 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 405535004566 ykoK leader 405535004567 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 405535004568 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405535004569 5'-3' exonuclease; Region: 53EXOc; smart00475 405535004570 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 405535004571 active site 405535004572 metal binding site 1 [ion binding]; metal-binding site 405535004573 putative 5' ssDNA interaction site; other site 405535004574 metal binding site 3; metal-binding site 405535004575 metal binding site 2 [ion binding]; metal-binding site 405535004576 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 405535004577 putative DNA binding site [nucleotide binding]; other site 405535004578 putative metal binding site [ion binding]; other site 405535004579 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 405535004580 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 405535004581 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 405535004582 Chain length determinant protein; Region: Wzz; cl15801 405535004583 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 405535004584 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 405535004585 Bacterial sugar transferase; Region: Bac_transf; pfam02397 405535004586 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 405535004587 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 405535004588 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 405535004589 O-Antigen ligase; Region: Wzy_C; pfam04932 405535004590 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405535004591 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 405535004592 active site 405535004593 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405535004594 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 405535004595 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 405535004596 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004597 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004598 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004599 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004600 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004601 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004602 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004603 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004604 Domain of unknown function DUF11; Region: DUF11; cl17728 405535004605 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004606 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004607 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004608 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004609 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004610 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004611 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004612 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004613 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004614 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004615 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004616 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004617 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004618 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004619 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004620 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004621 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004622 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004623 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535004624 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535004625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405535004626 Coenzyme A binding pocket [chemical binding]; other site 405535004627 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 405535004628 Isochorismatase family; Region: Isochorismatase; pfam00857 405535004629 catalytic triad [active] 405535004630 conserved cis-peptide bond; other site 405535004631 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405535004632 EamA-like transporter family; Region: EamA; pfam00892 405535004633 EamA-like transporter family; Region: EamA; cl17759 405535004634 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 405535004635 RNA/DNA hybrid binding site [nucleotide binding]; other site 405535004636 active site 405535004637 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 405535004638 active site 405535004639 catalytic residues [active] 405535004640 QueT transporter; Region: QueT; pfam06177 405535004641 hypothetical protein; Validated; Region: PRK07708 405535004642 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 405535004643 RNA/DNA hybrid binding site [nucleotide binding]; other site 405535004644 active site 405535004645 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 405535004646 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 405535004647 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405535004648 DNA-binding site [nucleotide binding]; DNA binding site 405535004649 RNA-binding motif; other site 405535004650 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 405535004651 LysE type translocator; Region: LysE; pfam01810 405535004652 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 405535004653 Protein of unknown function, DUF485; Region: DUF485; pfam04341 405535004654 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 405535004655 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 405535004656 Na binding site [ion binding]; other site 405535004657 aminotransferase; Validated; Region: PRK07678 405535004658 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405535004659 inhibitor-cofactor binding pocket; inhibition site 405535004660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535004661 catalytic residue [active] 405535004662 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 405535004663 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 405535004664 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 405535004665 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 405535004666 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405535004667 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 405535004668 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405535004669 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 405535004670 DNA binding residues [nucleotide binding] 405535004671 drug binding residues [chemical binding]; other site 405535004672 dimer interface [polypeptide binding]; other site 405535004673 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 405535004674 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 405535004675 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 405535004676 Predicted membrane protein [Function unknown]; Region: COG2323 405535004677 Uncharacterized conserved protein [Function unknown]; Region: COG1434 405535004678 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 405535004679 putative active site [active] 405535004680 Tic20-like protein; Region: Tic20; pfam09685 405535004681 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 405535004682 dimer interface [polypeptide binding]; other site 405535004683 FMN binding site [chemical binding]; other site 405535004684 NADPH bind site [chemical binding]; other site 405535004685 potential frameshift: common BLAST hit: gi|49184544|ref|YP_027796.1| thiJ/pfpI family protein 405535004686 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 405535004687 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 405535004688 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405535004689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535004690 H+ Antiporter protein; Region: 2A0121; TIGR00900 405535004691 putative substrate translocation pore; other site 405535004692 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535004693 dimerization interface [polypeptide binding]; other site 405535004694 putative DNA binding site [nucleotide binding]; other site 405535004695 putative Zn2+ binding site [ion binding]; other site 405535004696 H+ Antiporter protein; Region: 2A0121; TIGR00900 405535004697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535004698 putative substrate translocation pore; other site 405535004699 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405535004700 active site 405535004701 metal binding site [ion binding]; metal-binding site 405535004702 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405535004703 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 405535004704 bacterial Hfq-like; Region: Hfq; cd01716 405535004705 hexamer interface [polypeptide binding]; other site 405535004706 Sm1 motif; other site 405535004707 RNA binding site [nucleotide binding]; other site 405535004708 Sm2 motif; other site 405535004709 HD domain; Region: HD_3; pfam13023 405535004710 flagellar motor protein MotP; Reviewed; Region: PRK06743 405535004711 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 405535004712 flagellar motor protein MotS; Reviewed; Region: PRK06742 405535004713 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 405535004714 ligand binding site [chemical binding]; other site 405535004715 Response regulator receiver domain; Region: Response_reg; pfam00072 405535004716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535004717 active site 405535004718 phosphorylation site [posttranslational modification] 405535004719 intermolecular recognition site; other site 405535004720 dimerization interface [polypeptide binding]; other site 405535004721 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 405535004722 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 405535004723 putative binding surface; other site 405535004724 active site 405535004725 P2 response regulator binding domain; Region: P2; pfam07194 405535004726 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 405535004727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535004728 ATP binding site [chemical binding]; other site 405535004729 Mg2+ binding site [ion binding]; other site 405535004730 G-X-G motif; other site 405535004731 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 405535004732 flagellar motor switch protein; Reviewed; Region: PRK06782 405535004733 CheC-like family; Region: CheC; pfam04509 405535004734 CheC-like family; Region: CheC; pfam04509 405535004735 CheC-like family; Region: CheC; pfam04509 405535004736 CheC-like family; Region: CheC; pfam04509 405535004737 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 405535004738 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 405535004739 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 405535004740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535004741 Protein of unknown function (DUF327); Region: DUF327; pfam03885 405535004742 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 405535004743 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 405535004744 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 405535004745 flagellar capping protein; Validated; Region: fliD; PRK06798 405535004746 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 405535004747 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 405535004748 Flagellar protein FliS; Region: FliS; cl00654 405535004749 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 405535004750 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 405535004751 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 405535004752 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 405535004753 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 405535004754 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 405535004755 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 405535004756 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 405535004757 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 405535004758 FliG C-terminal domain; Region: FliG_C; pfam01706 405535004759 flagellar assembly protein H; Validated; Region: fliH; PRK06800 405535004760 Flagellar assembly protein FliH; Region: FliH; pfam02108 405535004761 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 405535004762 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 405535004763 Walker A motif; other site 405535004764 ATP binding site [chemical binding]; other site 405535004765 Walker B motif; other site 405535004766 CRISPR-associated protein Cpf1, subtype PREFRAN; Region: cas_Cpf1; TIGR04330 405535004767 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 405535004768 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 405535004769 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 405535004770 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 405535004771 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 405535004772 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 405535004773 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 405535004774 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 405535004775 Response regulator receiver domain; Region: Response_reg; pfam00072 405535004776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535004777 active site 405535004778 phosphorylation site [posttranslational modification] 405535004779 intermolecular recognition site; other site 405535004780 dimerization interface [polypeptide binding]; other site 405535004781 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 405535004782 flagellin; Provisional; Region: PRK12807 405535004783 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 405535004784 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 405535004785 flagellin; Provisional; Region: PRK12808 405535004786 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 405535004787 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 405535004788 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 405535004789 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 405535004790 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405535004791 catalytic residue [active] 405535004792 flagellar motor switch protein; Validated; Region: PRK06789 405535004793 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 405535004794 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 405535004795 flagellar motor switch protein; Validated; Region: PRK06788 405535004796 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 405535004797 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 405535004798 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 405535004799 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 405535004800 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 405535004801 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 405535004802 FHIPEP family; Region: FHIPEP; pfam00771 405535004803 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889 405535004804 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 405535004805 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 405535004806 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 405535004807 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 405535004808 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 405535004809 Predicted transcriptional regulators [Transcription]; Region: COG1378 405535004810 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 405535004811 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 405535004812 C-terminal domain interface [polypeptide binding]; other site 405535004813 sugar binding site [chemical binding]; other site 405535004814 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 405535004815 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 405535004816 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 405535004817 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535004818 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535004819 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 405535004820 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 405535004821 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 405535004822 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535004823 non-specific DNA binding site [nucleotide binding]; other site 405535004824 salt bridge; other site 405535004825 sequence-specific DNA binding site [nucleotide binding]; other site 405535004826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535004827 H+ Antiporter protein; Region: 2A0121; TIGR00900 405535004828 putative substrate translocation pore; other site 405535004829 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 405535004830 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 405535004831 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405535004832 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405535004833 dimerization interface [polypeptide binding]; other site 405535004834 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 405535004835 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535004836 Walker A/P-loop; other site 405535004837 ATP binding site [chemical binding]; other site 405535004838 Q-loop/lid; other site 405535004839 ABC transporter signature motif; other site 405535004840 Walker B; other site 405535004841 D-loop; other site 405535004842 H-loop/switch region; other site 405535004843 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 405535004844 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 405535004845 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 405535004846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535004847 dimer interface [polypeptide binding]; other site 405535004848 conserved gate region; other site 405535004849 putative PBP binding loops; other site 405535004850 ABC-ATPase subunit interface; other site 405535004851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535004852 dimer interface [polypeptide binding]; other site 405535004853 conserved gate region; other site 405535004854 putative PBP binding loops; other site 405535004855 ABC-ATPase subunit interface; other site 405535004856 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 405535004857 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 405535004858 Beta-Casp domain; Region: Beta-Casp; pfam10996 405535004859 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 405535004860 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 405535004861 Cupin; Region: Cupin_1; smart00835 405535004862 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 405535004863 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 405535004864 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405535004865 catalytic core [active] 405535004866 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405535004867 hypothetical protein; Provisional; Region: PRK09272 405535004868 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405535004869 MarR family; Region: MarR_2; pfam12802 405535004870 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 405535004871 potential frameshift: common BLAST hit: gi|49184639|ref|YP_027891.1| asparagine synthetase, glutamine-hydrolyzing 405535004872 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 405535004873 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 405535004874 active site 405535004875 dimer interface [polypeptide binding]; other site 405535004876 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 405535004877 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 405535004878 Ligand Binding Site [chemical binding]; other site 405535004879 Molecular Tunnel; other site 405535004880 RNA polymerase factor sigma-70; Validated; Region: PRK06811 405535004881 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405535004882 DNA binding residues [nucleotide binding] 405535004883 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 405535004884 VPS10 domain; Region: VPS10; smart00602 405535004885 VPS10 domain; Region: VPS10; smart00602 405535004886 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 405535004887 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 405535004888 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535004889 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 405535004890 DNA-binding site [nucleotide binding]; DNA binding site 405535004891 FCD domain; Region: FCD; pfam07729 405535004892 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405535004893 EamA-like transporter family; Region: EamA; pfam00892 405535004894 EamA-like transporter family; Region: EamA; pfam00892 405535004895 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 405535004896 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 405535004897 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 405535004898 Predicted permeases [General function prediction only]; Region: COG0701 405535004899 TIGR03943 family protein; Region: TIGR03943 405535004900 Methyltransferase domain; Region: Methyltransf_24; pfam13578 405535004901 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 405535004902 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405535004903 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 405535004904 DNA binding residues [nucleotide binding] 405535004905 putative dimer interface [polypeptide binding]; other site 405535004906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405535004907 C factor cell-cell signaling protein; Provisional; Region: PRK09009 405535004908 NAD(P) binding site [chemical binding]; other site 405535004909 active site 405535004910 fumarate hydratase; Reviewed; Region: fumC; PRK00485 405535004911 Class II fumarases; Region: Fumarase_classII; cd01362 405535004912 active site 405535004913 tetramer interface [polypeptide binding]; other site 405535004914 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 405535004915 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 405535004916 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 405535004917 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 405535004918 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 405535004919 active site pocket [active] 405535004920 oxyanion hole [active] 405535004921 catalytic triad [active] 405535004922 active site nucleophile [active] 405535004923 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 405535004924 Penicillinase repressor; Region: Pencillinase_R; pfam03965 405535004925 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 405535004926 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 405535004927 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 405535004928 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 405535004929 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 405535004930 catalytic residues [active] 405535004931 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 405535004932 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 405535004933 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535004934 non-specific DNA binding site [nucleotide binding]; other site 405535004935 salt bridge; other site 405535004936 sequence-specific DNA binding site [nucleotide binding]; other site 405535004937 Cupin domain; Region: Cupin_2; pfam07883 405535004938 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 405535004939 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405535004940 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 405535004941 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 405535004942 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405535004943 catalytic residue [active] 405535004944 Protein of unknown function (DUF445); Region: DUF445; pfam04286 405535004945 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 405535004946 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535004947 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405535004948 DNA binding residues [nucleotide binding] 405535004949 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405535004950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535004951 active site 405535004952 phosphorylation site [posttranslational modification] 405535004953 intermolecular recognition site; other site 405535004954 dimerization interface [polypeptide binding]; other site 405535004955 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405535004956 DNA binding residues [nucleotide binding] 405535004957 dimerization interface [polypeptide binding]; other site 405535004958 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405535004959 Histidine kinase; Region: HisKA_3; pfam07730 405535004960 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 405535004961 ATP binding site [chemical binding]; other site 405535004962 Mg2+ binding site [ion binding]; other site 405535004963 G-X-G motif; other site 405535004964 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405535004965 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535004966 Walker A/P-loop; other site 405535004967 ATP binding site [chemical binding]; other site 405535004968 Q-loop/lid; other site 405535004969 ABC transporter signature motif; other site 405535004970 Walker B; other site 405535004971 D-loop; other site 405535004972 H-loop/switch region; other site 405535004973 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 405535004974 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 405535004975 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 405535004976 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 405535004977 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405535004978 PLD-like domain; Region: PLDc_2; pfam13091 405535004979 putative active site [active] 405535004980 catalytic site [active] 405535004981 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 405535004982 PLD-like domain; Region: PLDc_2; pfam13091 405535004983 putative active site [active] 405535004984 catalytic site [active] 405535004985 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 405535004986 putative nucleotide binding site [chemical binding]; other site 405535004987 uridine monophosphate binding site [chemical binding]; other site 405535004988 homohexameric interface [polypeptide binding]; other site 405535004989 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405535004990 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 405535004991 aspartate ammonia-lyase; Provisional; Region: PRK14515 405535004992 Aspartase; Region: Aspartase; cd01357 405535004993 active sites [active] 405535004994 tetramer interface [polypeptide binding]; other site 405535004995 malate dehydrogenase; Provisional; Region: PRK13529 405535004996 Malic enzyme, N-terminal domain; Region: malic; pfam00390 405535004997 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 405535004998 NAD(P) binding site [chemical binding]; other site 405535004999 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535005000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535005001 ATP binding site [chemical binding]; other site 405535005002 Mg2+ binding site [ion binding]; other site 405535005003 G-X-G motif; other site 405535005004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535005005 Response regulator receiver domain; Region: Response_reg; pfam00072 405535005006 active site 405535005007 phosphorylation site [posttranslational modification] 405535005008 intermolecular recognition site; other site 405535005009 dimerization interface [polypeptide binding]; other site 405535005010 YcbB domain; Region: YcbB; pfam08664 405535005011 SWIM zinc finger; Region: SWIM; pfam04434 405535005012 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 405535005013 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 405535005014 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405535005015 ATP binding site [chemical binding]; other site 405535005016 putative Mg++ binding site [ion binding]; other site 405535005017 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405535005018 nucleotide binding region [chemical binding]; other site 405535005019 ATP-binding site [chemical binding]; other site 405535005020 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 405535005021 dimer interface [polypeptide binding]; other site 405535005022 active site 405535005023 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535005024 non-specific DNA binding site [nucleotide binding]; other site 405535005025 salt bridge; other site 405535005026 sequence-specific DNA binding site [nucleotide binding]; other site 405535005027 Helix-turn-helix; Region: HTH_3; pfam01381 405535005028 salt bridge; other site 405535005029 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 405535005030 putative dimer interface [polypeptide binding]; other site 405535005031 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405535005032 aspartate kinase; Reviewed; Region: PRK06635 405535005033 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 405535005034 putative nucleotide binding site [chemical binding]; other site 405535005035 putative catalytic residues [active] 405535005036 putative Mg ion binding site [ion binding]; other site 405535005037 putative aspartate binding site [chemical binding]; other site 405535005038 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 405535005039 putative allosteric regulatory site; other site 405535005040 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 405535005041 putative allosteric regulatory residue; other site 405535005042 Lysine riboswitch 405535005043 DoxX-like family; Region: DoxX_3; pfam13781 405535005044 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 405535005045 YndJ-like protein; Region: YndJ; pfam14158 405535005046 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 405535005047 putative active site [active] 405535005048 nucleotide binding site [chemical binding]; other site 405535005049 nudix motif; other site 405535005050 putative metal binding site [ion binding]; other site 405535005051 S-layer homology domain; Region: SLH; pfam00395 405535005052 S-layer homology domain; Region: SLH; pfam00395 405535005053 S-layer homology domain; Region: SLH; pfam00395 405535005054 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 405535005055 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405535005056 active site 405535005057 metal binding site [ion binding]; metal-binding site 405535005058 S-layer homology domain; Region: SLH; pfam00395 405535005059 S-layer homology domain; Region: SLH; pfam00395 405535005060 S-layer homology domain; Region: SLH; pfam00395 405535005061 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 405535005062 H+ Antiporter protein; Region: 2A0121; TIGR00900 405535005063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535005064 putative substrate translocation pore; other site 405535005065 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 405535005066 Carbon starvation protein CstA; Region: CstA; pfam02554 405535005067 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 405535005068 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 405535005069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535005070 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405535005071 putative substrate translocation pore; other site 405535005072 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 405535005073 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 405535005074 dimer interface [polypeptide binding]; other site 405535005075 active site 405535005076 CoA binding pocket [chemical binding]; other site 405535005077 NTR domain, TIMP-like subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by...; Region: NTR_TIMP_like; cd03577 405535005078 Metzincin-binding interface; other site 405535005079 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 405535005080 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 405535005081 HflX GTPase family; Region: HflX; cd01878 405535005082 G1 box; other site 405535005083 GTP/Mg2+ binding site [chemical binding]; other site 405535005084 Switch I region; other site 405535005085 G2 box; other site 405535005086 G3 box; other site 405535005087 Switch II region; other site 405535005088 G4 box; other site 405535005089 G5 box; other site 405535005090 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405535005091 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405535005092 peptide binding site [polypeptide binding]; other site 405535005093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535005094 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405535005095 putative substrate translocation pore; other site 405535005096 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 405535005097 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 405535005098 dimer interface [polypeptide binding]; other site 405535005099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535005100 catalytic residue [active] 405535005101 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535005102 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405535005103 Coenzyme A binding pocket [chemical binding]; other site 405535005104 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 405535005105 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405535005106 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 405535005107 Na2 binding site [ion binding]; other site 405535005108 putative substrate binding site 1 [chemical binding]; other site 405535005109 Na binding site 1 [ion binding]; other site 405535005110 putative substrate binding site 2 [chemical binding]; other site 405535005111 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405535005112 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 405535005113 NodB motif; other site 405535005114 putative active site [active] 405535005115 putative catalytic site [active] 405535005116 putative Zn binding site [ion binding]; other site 405535005117 Mor transcription activator family; Region: Mor; cl02360 405535005118 Predicted membrane protein [Function unknown]; Region: COG2323 405535005119 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 405535005120 methionine sulfoxide reductase A; Provisional; Region: PRK14054 405535005121 short chain dehydrogenase; Provisional; Region: PRK12747 405535005122 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 405535005123 NADP binding site [chemical binding]; other site 405535005124 homodimer interface [polypeptide binding]; other site 405535005125 active site 405535005126 substrate binding site [chemical binding]; other site 405535005127 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 405535005128 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 405535005129 homodimer interface [polypeptide binding]; other site 405535005130 substrate-cofactor binding pocket; other site 405535005131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535005132 catalytic residue [active] 405535005133 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 405535005134 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 405535005135 PYR/PP interface [polypeptide binding]; other site 405535005136 dimer interface [polypeptide binding]; other site 405535005137 TPP binding site [chemical binding]; other site 405535005138 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405535005139 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 405535005140 TPP-binding site [chemical binding]; other site 405535005141 dimer interface [polypeptide binding]; other site 405535005142 acetolactate synthase 1 regulatory subunit; Validated; Region: PRK06737 405535005143 ketol-acid reductoisomerase; Provisional; Region: PRK05479 405535005144 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 405535005145 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 405535005146 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 405535005147 threonine dehydratase; Validated; Region: PRK08639 405535005148 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 405535005149 tetramer interface [polypeptide binding]; other site 405535005150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535005151 catalytic residue [active] 405535005152 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 405535005153 putative Ile/Val binding site [chemical binding]; other site 405535005154 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 405535005155 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 405535005156 putative active site [active] 405535005157 putative metal binding site [ion binding]; other site 405535005158 Protein of unknown function (DUF554); Region: DUF554; pfam04474 405535005159 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535005160 Coenzyme A binding pocket [chemical binding]; other site 405535005161 drug efflux system protein MdtG; Provisional; Region: PRK09874 405535005162 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535005163 putative substrate translocation pore; other site 405535005164 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 405535005165 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 405535005166 putative active site [active] 405535005167 metal binding site [ion binding]; metal-binding site 405535005168 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 405535005169 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405535005170 LytTr DNA-binding domain; Region: LytTR; pfam04397 405535005171 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 405535005172 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 405535005173 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 405535005174 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 405535005175 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405535005176 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535005177 Coenzyme A binding pocket [chemical binding]; other site 405535005178 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 405535005179 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 405535005180 active site 405535005181 putative substrate binding pocket [chemical binding]; other site 405535005182 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405535005183 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405535005184 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405535005185 peptide binding site [polypeptide binding]; other site 405535005186 hypothetical protein; Provisional; Region: PRK06922 405535005187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535005188 S-adenosylmethionine binding site [chemical binding]; other site 405535005189 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 405535005190 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405535005191 FeS/SAM binding site; other site 405535005192 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 405535005193 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405535005194 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535005195 Coenzyme A binding pocket [chemical binding]; other site 405535005196 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535005197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535005198 active site 405535005199 phosphorylation site [posttranslational modification] 405535005200 intermolecular recognition site; other site 405535005201 dimerization interface [polypeptide binding]; other site 405535005202 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535005203 DNA binding site [nucleotide binding] 405535005204 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535005205 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535005206 dimerization interface [polypeptide binding]; other site 405535005207 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535005208 dimer interface [polypeptide binding]; other site 405535005209 phosphorylation site [posttranslational modification] 405535005210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535005211 ATP binding site [chemical binding]; other site 405535005212 Mg2+ binding site [ion binding]; other site 405535005213 G-X-G motif; other site 405535005214 Peptidase family M23; Region: Peptidase_M23; pfam01551 405535005215 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405535005216 manganese transport protein MntH; Reviewed; Region: PRK00701 405535005217 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 405535005218 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 405535005219 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 405535005220 active site residue [active] 405535005221 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 405535005222 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 405535005223 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 405535005224 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 405535005225 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 405535005226 ydaO/yuaA leader 405535005227 Amino acid permease; Region: AA_permease_2; pfam13520 405535005228 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405535005229 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405535005230 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405535005231 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 405535005232 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 405535005233 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405535005234 DNA binding residues [nucleotide binding] 405535005235 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 405535005236 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 405535005237 intersubunit interface [polypeptide binding]; other site 405535005238 active site 405535005239 catalytic residue [active] 405535005240 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405535005241 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405535005242 Nucleoside recognition; Region: Gate; pfam07670 405535005243 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405535005244 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 405535005245 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 405535005246 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 405535005247 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 405535005248 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 405535005249 active site 405535005250 catalytic motif [active] 405535005251 Zn binding site [ion binding]; other site 405535005252 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 405535005253 hypothetical protein; Provisional; Region: PRK01631 405535005254 Family description; Region: DsbD_2; pfam13386 405535005255 VPS10 domain; Region: VPS10; smart00602 405535005256 proline aminopeptidase P II; Provisional; Region: PRK10879 405535005257 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 405535005258 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 405535005259 active site 405535005260 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 405535005261 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 405535005262 Multicopper oxidase; Region: Cu-oxidase; pfam00394 405535005263 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 405535005264 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535005265 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535005266 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535005267 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535005268 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535005269 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405535005270 Peptidase family M23; Region: Peptidase_M23; pfam01551 405535005271 DNA topoisomerase III; Provisional; Region: PRK07726 405535005272 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 405535005273 active site 405535005274 putative interdomain interaction site [polypeptide binding]; other site 405535005275 putative metal-binding site [ion binding]; other site 405535005276 putative nucleotide binding site [chemical binding]; other site 405535005277 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 405535005278 domain I; other site 405535005279 DNA binding groove [nucleotide binding] 405535005280 phosphate binding site [ion binding]; other site 405535005281 domain II; other site 405535005282 domain III; other site 405535005283 nucleotide binding site [chemical binding]; other site 405535005284 catalytic site [active] 405535005285 domain IV; other site 405535005286 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 405535005287 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 405535005288 H+ Antiporter protein; Region: 2A0121; TIGR00900 405535005289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535005290 putative substrate translocation pore; other site 405535005291 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 405535005292 Sodium Bile acid symporter family; Region: SBF; cl17470 405535005293 azoreductase; Provisional; Region: PRK13555 405535005294 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405535005295 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405535005296 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 405535005297 dimer interface [polypeptide binding]; other site 405535005298 substrate binding site [chemical binding]; other site 405535005299 metal binding site [ion binding]; metal-binding site 405535005300 potential frameshift: common BLAST hit: gi|118477373|ref|YP_894524.1| copper resistance protein 405535005301 CopC domain; Region: CopC; cl01012 405535005302 CopC domain; Region: CopC; cl01012 405535005303 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 405535005304 YtkA-like; Region: YtkA; pfam13115 405535005305 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 405535005306 EamA-like transporter family; Region: EamA; pfam00892 405535005307 EamA-like transporter family; Region: EamA; pfam00892 405535005308 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405535005309 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405535005310 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405535005311 dimerization interface [polypeptide binding]; other site 405535005312 Predicted transcriptional regulator [Transcription]; Region: COG1959 405535005313 Transcriptional regulator; Region: Rrf2; pfam02082 405535005314 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 405535005315 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 405535005316 catalytic residues [active] 405535005317 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 405535005318 dimer interface [polypeptide binding]; other site 405535005319 FMN binding site [chemical binding]; other site 405535005320 amidase; Provisional; Region: PRK06707 405535005321 Amidase; Region: Amidase; cl11426 405535005322 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 405535005323 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 405535005324 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 405535005325 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405535005326 NAD binding site [chemical binding]; other site 405535005327 dimer interface [polypeptide binding]; other site 405535005328 substrate binding site [chemical binding]; other site 405535005329 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 405535005330 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405535005331 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 405535005332 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 405535005333 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 405535005334 S-layer homology domain; Region: SLH; pfam00395 405535005335 S-layer homology domain; Region: SLH; pfam00395 405535005336 S-layer homology domain; Region: SLH; pfam00395 405535005337 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535005338 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535005339 acyl-CoA synthetase; Validated; Region: PRK06839 405535005340 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405535005341 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 405535005342 acyl-activating enzyme (AAE) consensus motif; other site 405535005343 putative AMP binding site [chemical binding]; other site 405535005344 putative active site [active] 405535005345 putative CoA binding site [chemical binding]; other site 405535005346 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 405535005347 dimer interaction site [polypeptide binding]; other site 405535005348 substrate-binding tunnel; other site 405535005349 active site 405535005350 catalytic site [active] 405535005351 substrate binding site [chemical binding]; other site 405535005352 hypothetical protein; Validated; Region: PRK06840 405535005353 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 405535005354 active site 405535005355 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 405535005356 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 405535005357 putative ligand binding site [chemical binding]; other site 405535005358 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 405535005359 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 405535005360 Walker A/P-loop; other site 405535005361 ATP binding site [chemical binding]; other site 405535005362 Q-loop/lid; other site 405535005363 ABC transporter signature motif; other site 405535005364 Walker B; other site 405535005365 D-loop; other site 405535005366 H-loop/switch region; other site 405535005367 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 405535005368 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 405535005369 Walker A/P-loop; other site 405535005370 ATP binding site [chemical binding]; other site 405535005371 Q-loop/lid; other site 405535005372 ABC transporter signature motif; other site 405535005373 Walker B; other site 405535005374 D-loop; other site 405535005375 H-loop/switch region; other site 405535005376 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405535005377 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 405535005378 TM-ABC transporter signature motif; other site 405535005379 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 405535005380 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 405535005381 TM-ABC transporter signature motif; other site 405535005382 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405535005383 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 405535005384 LysR substrate binding domain; Region: LysR_substrate; pfam03466 405535005385 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 405535005386 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405535005387 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535005388 putative Zn2+ binding site [ion binding]; other site 405535005389 putative DNA binding site [nucleotide binding]; other site 405535005390 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 405535005391 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 405535005392 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 405535005393 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 405535005394 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 405535005395 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 405535005396 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 405535005397 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 405535005398 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405535005399 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 405535005400 Walker A/P-loop; other site 405535005401 ATP binding site [chemical binding]; other site 405535005402 Q-loop/lid; other site 405535005403 ABC transporter signature motif; other site 405535005404 Walker B; other site 405535005405 D-loop; other site 405535005406 H-loop/switch region; other site 405535005407 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 405535005408 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405535005409 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 405535005410 Walker A/P-loop; other site 405535005411 ATP binding site [chemical binding]; other site 405535005412 Q-loop/lid; other site 405535005413 ABC transporter signature motif; other site 405535005414 Walker B; other site 405535005415 D-loop; other site 405535005416 H-loop/switch region; other site 405535005417 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 405535005418 putative dimer interface [polypeptide binding]; other site 405535005419 catalytic triad [active] 405535005420 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405535005421 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 405535005422 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 405535005423 dimer interface [polypeptide binding]; other site 405535005424 FMN binding site [chemical binding]; other site 405535005425 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535005426 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535005427 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535005428 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405535005429 NlpC/P60 family; Region: NLPC_P60; pfam00877 405535005430 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405535005431 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405535005432 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405535005433 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535005434 Walker A/P-loop; other site 405535005435 ATP binding site [chemical binding]; other site 405535005436 Q-loop/lid; other site 405535005437 ABC transporter signature motif; other site 405535005438 Walker B; other site 405535005439 D-loop; other site 405535005440 H-loop/switch region; other site 405535005441 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535005442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535005443 active site 405535005444 phosphorylation site [posttranslational modification] 405535005445 intermolecular recognition site; other site 405535005446 dimerization interface [polypeptide binding]; other site 405535005447 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535005448 DNA binding site [nucleotide binding] 405535005449 potential frameshift: common BLAST hit: gi|49477450|ref|YP_036123.1| sensor histidine kinase 405535005450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535005451 dimer interface [polypeptide binding]; other site 405535005452 phosphorylation site [posttranslational modification] 405535005453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535005454 ATP binding site [chemical binding]; other site 405535005455 Mg2+ binding site [ion binding]; other site 405535005456 G-X-G motif; other site 405535005457 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 405535005458 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 405535005459 classical (c) SDRs; Region: SDR_c; cd05233 405535005460 NAD(P) binding site [chemical binding]; other site 405535005461 active site 405535005462 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 405535005463 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405535005464 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 405535005465 NodB motif; other site 405535005466 active site 405535005467 catalytic site [active] 405535005468 metal binding site [ion binding]; metal-binding site 405535005469 SdpI/YhfL protein family; Region: SdpI; pfam13630 405535005470 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 405535005471 nudix motif; other site 405535005472 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 405535005473 homoserine dehydrogenase; Provisional; Region: PRK06349 405535005474 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 405535005475 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 405535005476 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 405535005477 threonine synthase; Reviewed; Region: PRK06721 405535005478 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 405535005479 homodimer interface [polypeptide binding]; other site 405535005480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535005481 catalytic residue [active] 405535005482 homoserine kinase; Provisional; Region: PRK01212 405535005483 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 405535005484 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 405535005485 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 405535005486 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 405535005487 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535005488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535005489 active site 405535005490 phosphorylation site [posttranslational modification] 405535005491 intermolecular recognition site; other site 405535005492 dimerization interface [polypeptide binding]; other site 405535005493 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535005494 DNA binding site [nucleotide binding] 405535005495 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535005496 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535005497 dimerization interface [polypeptide binding]; other site 405535005498 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535005499 dimer interface [polypeptide binding]; other site 405535005500 phosphorylation site [posttranslational modification] 405535005501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535005502 ATP binding site [chemical binding]; other site 405535005503 Mg2+ binding site [ion binding]; other site 405535005504 G-X-G motif; other site 405535005505 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405535005506 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 405535005507 NodB motif; other site 405535005508 active site 405535005509 catalytic site [active] 405535005510 Zn binding site [ion binding]; other site 405535005511 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 405535005512 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 405535005513 MgtC family; Region: MgtC; pfam02308 405535005514 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405535005515 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535005516 Coenzyme A binding pocket [chemical binding]; other site 405535005517 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 405535005518 IucA / IucC family; Region: IucA_IucC; pfam04183 405535005519 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 405535005520 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 405535005521 IucA / IucC family; Region: IucA_IucC; pfam04183 405535005522 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 405535005523 acyl-CoA synthetase; Validated; Region: PRK08308 405535005524 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405535005525 acyl-activating enzyme (AAE) consensus motif; other site 405535005526 AMP binding site [chemical binding]; other site 405535005527 active site 405535005528 CoA binding site [chemical binding]; other site 405535005529 acyl carrier protein; Provisional; Region: PRK07639 405535005530 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 405535005531 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405535005532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535005533 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405535005534 putative substrate translocation pore; other site 405535005535 Lysine efflux permease [General function prediction only]; Region: COG1279 405535005536 Protein of unknown function (DUF3933); Region: DUF3933; pfam13069 405535005537 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 405535005538 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 405535005539 active site 405535005540 nucleophile elbow; other site 405535005541 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 405535005542 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 405535005543 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 405535005544 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 405535005545 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 405535005546 nudix motif; other site 405535005547 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 405535005548 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 405535005549 homodimer interface [polypeptide binding]; other site 405535005550 NAD binding pocket [chemical binding]; other site 405535005551 ATP binding pocket [chemical binding]; other site 405535005552 Mg binding site [ion binding]; other site 405535005553 active-site loop [active] 405535005554 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405535005555 FtsX-like permease family; Region: FtsX; pfam02687 405535005556 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 405535005557 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 405535005558 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 405535005559 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 405535005560 active site 405535005561 catalytic residues [active] 405535005562 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535005563 dimerization interface [polypeptide binding]; other site 405535005564 putative DNA binding site [nucleotide binding]; other site 405535005565 putative Zn2+ binding site [ion binding]; other site 405535005566 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405535005567 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405535005568 active site 405535005569 catalytic tetrad [active] 405535005570 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 405535005571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535005572 putative substrate translocation pore; other site 405535005573 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 405535005574 Protein of unknown function (DUF664); Region: DUF664; pfam04978 405535005575 DinB superfamily; Region: DinB_2; pfam12867 405535005576 GTPase RsgA; Reviewed; Region: PRK01889 405535005577 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 405535005578 RNA binding site [nucleotide binding]; other site 405535005579 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 405535005580 GTPase/Zn-binding domain interface [polypeptide binding]; other site 405535005581 GTP/Mg2+ binding site [chemical binding]; other site 405535005582 G4 box; other site 405535005583 G5 box; other site 405535005584 G1 box; other site 405535005585 Switch I region; other site 405535005586 G2 box; other site 405535005587 G3 box; other site 405535005588 Switch II region; other site 405535005589 Tar ligand binding domain homologue; Region: TarH; pfam02203 405535005590 Cache domain; Region: Cache_1; pfam02743 405535005591 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 405535005592 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535005593 dimerization interface [polypeptide binding]; other site 405535005594 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405535005595 dimer interface [polypeptide binding]; other site 405535005596 putative CheW interface [polypeptide binding]; other site 405535005597 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 405535005598 Uncharacterized membrane protein [Function unknown]; Region: COG3949 405535005599 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 405535005600 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 405535005601 dimerization interface [polypeptide binding]; other site 405535005602 DPS ferroxidase diiron center [ion binding]; other site 405535005603 ion pore; other site 405535005604 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 405535005605 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 405535005606 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 405535005607 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 405535005608 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 405535005609 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 405535005610 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 405535005611 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405535005612 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405535005613 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405535005614 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405535005615 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405535005616 active site 405535005617 catalytic tetrad [active] 405535005618 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 405535005619 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 405535005620 P-loop, Walker A motif; other site 405535005621 Base recognition motif; other site 405535005622 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 405535005623 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405535005624 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535005625 Coenzyme A binding pocket [chemical binding]; other site 405535005626 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959 405535005627 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 405535005628 potential frameshift: common BLAST hit: gi|52143391|ref|YP_083436.1| high-affinity zinc uptake system periplasmic-binding protein 405535005629 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 405535005630 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 405535005631 metal binding site [ion binding]; metal-binding site 405535005632 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 405535005633 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 405535005634 NADH(P)-binding; Region: NAD_binding_10; pfam13460 405535005635 NAD binding site [chemical binding]; other site 405535005636 active site 405535005637 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 405535005638 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 405535005639 active site 405535005640 FMN binding site [chemical binding]; other site 405535005641 substrate binding site [chemical binding]; other site 405535005642 homotetramer interface [polypeptide binding]; other site 405535005643 catalytic residue [active] 405535005644 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 405535005645 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 405535005646 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 405535005647 DNA binding site [nucleotide binding] 405535005648 active site 405535005649 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 405535005650 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405535005651 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405535005652 peptide binding site [polypeptide binding]; other site 405535005653 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 405535005654 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405535005655 active site 405535005656 metal binding site [ion binding]; metal-binding site 405535005657 short chain dehydrogenase; Provisional; Region: PRK08309 405535005658 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405535005659 catalytic core [active] 405535005660 CotH protein; Region: CotH; pfam08757 405535005661 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 405535005662 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 405535005663 nudix motif; other site 405535005664 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405535005665 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405535005666 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 405535005667 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405535005668 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 405535005669 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 405535005670 Cl binding site [ion binding]; other site 405535005671 oligomer interface [polypeptide binding]; other site 405535005672 Predicted permeases [General function prediction only]; Region: COG0701 405535005673 Predicted membrane protein [Function unknown]; Region: COG3689 405535005674 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 405535005675 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 405535005676 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405535005677 putative active site [active] 405535005678 catalytic site [active] 405535005679 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 405535005680 putative active site [active] 405535005681 catalytic site [active] 405535005682 Coat F domain; Region: Coat_F; pfam07875 405535005683 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 405535005684 NADH(P)-binding; Region: NAD_binding_10; pfam13460 405535005685 NAD binding site [chemical binding]; other site 405535005686 substrate binding site [chemical binding]; other site 405535005687 putative active site [active] 405535005688 Protein of unknown function (DUF456); Region: DUF456; pfam04306 405535005689 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 405535005690 Domain of unknown function DUF21; Region: DUF21; pfam01595 405535005691 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 405535005692 Transporter associated domain; Region: CorC_HlyC; smart01091 405535005693 FOG: CBS domain [General function prediction only]; Region: COG0517 405535005694 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 405535005695 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405535005696 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 405535005697 dimer interface [polypeptide binding]; other site 405535005698 putative tRNA-binding site [nucleotide binding]; other site 405535005699 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 405535005700 DinB superfamily; Region: DinB_2; pfam12867 405535005701 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 405535005702 stage II sporulation protein P; Region: spore_II_P; TIGR02867 405535005703 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405535005704 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535005705 Coenzyme A binding pocket [chemical binding]; other site 405535005706 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405535005707 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 405535005708 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 405535005709 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+ for their activity and contain a highly...; Region: Nudix_Hydrolase_6; cd04663 405535005710 nudix motif; other site 405535005711 amidase; Provisional; Region: PRK06828 405535005712 Amidase; Region: Amidase; pfam01425 405535005713 H+ Antiporter protein; Region: 2A0121; TIGR00900 405535005714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535005715 putative substrate translocation pore; other site 405535005716 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 405535005717 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 405535005718 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 405535005719 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405535005720 catalytic core [active] 405535005721 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535005722 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405535005723 active site 405535005724 motif I; other site 405535005725 motif II; other site 405535005726 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535005727 DinB superfamily; Region: DinB_2; pfam12867 405535005728 DinB family; Region: DinB; cl17821 405535005729 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 405535005730 alanine racemase; Reviewed; Region: alr; PRK00053 405535005731 active site 405535005732 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405535005733 dimer interface [polypeptide binding]; other site 405535005734 substrate binding site [chemical binding]; other site 405535005735 catalytic residues [active] 405535005736 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405535005737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535005738 S-adenosylmethionine binding site [chemical binding]; other site 405535005739 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535005740 Coenzyme A binding pocket [chemical binding]; other site 405535005741 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535005742 Coenzyme A binding pocket [chemical binding]; other site 405535005743 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 405535005744 glycosyltransferase, MGT family; Region: MGT; TIGR01426 405535005745 active site 405535005746 TDP-binding site; other site 405535005747 acceptor substrate-binding pocket; other site 405535005748 homodimer interface [polypeptide binding]; other site 405535005749 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405535005750 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405535005751 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405535005752 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405535005753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535005754 DNA-binding site [nucleotide binding]; DNA binding site 405535005755 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405535005756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535005757 homodimer interface [polypeptide binding]; other site 405535005758 catalytic residue [active] 405535005759 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535005760 Coenzyme A binding pocket [chemical binding]; other site 405535005761 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405535005762 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 405535005763 active site 405535005764 metal binding site [ion binding]; metal-binding site 405535005765 Src Homology 3 domain superfamily; Region: SH3; cl17036 405535005766 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405535005767 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535005768 Coenzyme A binding pocket [chemical binding]; other site 405535005769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405535005770 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 405535005771 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405535005772 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535005773 Coenzyme A binding pocket [chemical binding]; other site 405535005774 Cupin domain; Region: Cupin_2; cl17218 405535005775 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 405535005776 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405535005777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535005778 S-adenosylmethionine binding site [chemical binding]; other site 405535005779 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 405535005780 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 405535005781 Potassium binding sites [ion binding]; other site 405535005782 Cesium cation binding sites [ion binding]; other site 405535005783 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 405535005784 DEAD-like helicases superfamily; Region: DEXDc; smart00487 405535005785 ATP binding site [chemical binding]; other site 405535005786 putative Mg++ binding site [ion binding]; other site 405535005787 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405535005788 nucleotide binding region [chemical binding]; other site 405535005789 ATP-binding site [chemical binding]; other site 405535005790 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 405535005791 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405535005792 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 405535005793 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405535005794 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 405535005795 NADP binding site [chemical binding]; other site 405535005796 dimer interface [polypeptide binding]; other site 405535005797 RNA polymerase sigma factor; Provisional; Region: PRK12543 405535005798 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535005799 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405535005800 DNA binding residues [nucleotide binding] 405535005801 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 405535005802 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 405535005803 ABC1 family; Region: ABC1; cl17513 405535005804 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405535005805 Protein of unknown function (DUF3925); Region: DUF3925; pfam13063 405535005806 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 405535005807 catalytic residues [active] 405535005808 dimer interface [polypeptide binding]; other site 405535005809 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 405535005810 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 405535005811 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 405535005812 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 405535005813 Protein of unknown function DUF58; Region: DUF58; pfam01882 405535005814 MoxR-like ATPases [General function prediction only]; Region: COG0714 405535005815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535005816 Walker A motif; other site 405535005817 ATP binding site [chemical binding]; other site 405535005818 Walker B motif; other site 405535005819 arginine finger; other site 405535005820 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 405535005821 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 405535005822 [4Fe-4S] binding site [ion binding]; other site 405535005823 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405535005824 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405535005825 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405535005826 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 405535005827 molybdopterin cofactor binding site; other site 405535005828 nitrate reductase, beta subunit; Region: narH; TIGR01660 405535005829 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 405535005830 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 405535005831 Predicted transcriptional regulators [Transcription]; Region: COG1725 405535005832 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535005833 DNA-binding site [nucleotide binding]; DNA binding site 405535005834 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405535005835 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405535005836 Walker A/P-loop; other site 405535005837 ATP binding site [chemical binding]; other site 405535005838 Q-loop/lid; other site 405535005839 ABC transporter signature motif; other site 405535005840 Walker B; other site 405535005841 D-loop; other site 405535005842 H-loop/switch region; other site 405535005843 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 405535005844 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 405535005845 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405535005846 ligand binding site [chemical binding]; other site 405535005847 flexible hinge region; other site 405535005848 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 405535005849 putative switch regulator; other site 405535005850 non-specific DNA interactions [nucleotide binding]; other site 405535005851 DNA binding site [nucleotide binding] 405535005852 sequence specific DNA binding site [nucleotide binding]; other site 405535005853 putative cAMP binding site [chemical binding]; other site 405535005854 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 405535005855 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405535005856 FeS/SAM binding site; other site 405535005857 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 405535005858 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 405535005859 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 405535005860 ATP binding site [chemical binding]; other site 405535005861 substrate interface [chemical binding]; other site 405535005862 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 405535005863 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 405535005864 dimer interface [polypeptide binding]; other site 405535005865 putative functional site; other site 405535005866 putative MPT binding site; other site 405535005867 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 405535005868 MoaE homodimer interface [polypeptide binding]; other site 405535005869 MoaD interaction [polypeptide binding]; other site 405535005870 active site residues [active] 405535005871 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 405535005872 MoaE interaction surface [polypeptide binding]; other site 405535005873 MoeB interaction surface [polypeptide binding]; other site 405535005874 thiocarboxylated glycine; other site 405535005875 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 405535005876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535005877 putative substrate translocation pore; other site 405535005878 Predicted permeases [General function prediction only]; Region: COG0679 405535005879 precorrin-2 dehydrogenase; Validated; Region: PRK06719 405535005880 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 405535005881 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 405535005882 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 405535005883 putative active site [active] 405535005884 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 405535005885 putative active site [active] 405535005886 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 405535005887 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 405535005888 active site 405535005889 SAM binding site [chemical binding]; other site 405535005890 homodimer interface [polypeptide binding]; other site 405535005891 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 405535005892 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 405535005893 [2Fe-2S] cluster binding site [ion binding]; other site 405535005894 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 405535005895 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405535005896 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405535005897 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 405535005898 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 405535005899 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 405535005900 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 405535005901 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 405535005902 Hemerythrin-like domain; Region: Hr-like; cd12108 405535005903 Fe binding site [ion binding]; other site 405535005904 Excalibur calcium-binding domain; Region: Excalibur; smart00894 405535005905 N-acetyltransferase; Region: Acetyltransf_2; cl00949 405535005906 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 405535005907 PGAP1-like protein; Region: PGAP1; pfam07819 405535005908 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 405535005909 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 405535005910 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405535005911 Zn2+ binding site [ion binding]; other site 405535005912 Mg2+ binding site [ion binding]; other site 405535005913 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 405535005914 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405535005915 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405535005916 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405535005917 ABC transporter; Region: ABC_tran_2; pfam12848 405535005918 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405535005919 Bax inhibitor 1 like; Region: BaxI_1; cl17691 405535005920 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 405535005921 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 405535005922 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 405535005923 dimer interface [polypeptide binding]; other site 405535005924 ssDNA binding site [nucleotide binding]; other site 405535005925 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405535005926 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 405535005927 Virulence factor; Region: Virulence_fact; pfam13769 405535005928 HEAT repeats; Region: HEAT_2; pfam13646 405535005929 HEAT repeats; Region: HEAT_2; pfam13646 405535005930 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 405535005931 Protein of unknown function, DUF393; Region: DUF393; pfam04134 405535005932 Disulphide isomerase; Region: Disulph_isomer; pfam06491 405535005933 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 405535005934 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 405535005935 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 405535005936 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 405535005937 active site 405535005938 HIGH motif; other site 405535005939 KMSK motif region; other site 405535005940 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 405535005941 tRNA binding surface [nucleotide binding]; other site 405535005942 anticodon binding site; other site 405535005943 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405535005944 Methyltransferase domain; Region: Methyltransf_12; pfam08242 405535005945 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 405535005946 putative active site [active] 405535005947 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 405535005948 binding surface 405535005949 TPR motif; other site 405535005950 TPR repeat; Region: TPR_11; pfam13414 405535005951 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535005952 binding surface 405535005953 TPR motif; other site 405535005954 Tetratricopeptide repeat; Region: TPR_16; pfam13432 405535005955 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535005956 binding surface 405535005957 TPR motif; other site 405535005958 TPR repeat; Region: TPR_11; pfam13414 405535005959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535005960 binding surface 405535005961 TPR motif; other site 405535005962 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535005963 binding surface 405535005964 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405535005965 TPR motif; other site 405535005966 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535005967 binding surface 405535005968 TPR motif; other site 405535005969 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405535005970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535005971 binding surface 405535005972 TPR motif; other site 405535005973 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 405535005974 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 405535005975 HIGH motif; other site 405535005976 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 405535005977 active site 405535005978 KMSKS motif; other site 405535005979 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 405535005980 tRNA binding surface [nucleotide binding]; other site 405535005981 anticodon binding site; other site 405535005982 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405535005983 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405535005984 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 405535005985 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 405535005986 Zn binding site [ion binding]; other site 405535005987 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 405535005988 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 405535005989 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405535005990 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 405535005991 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 405535005992 Dimer interface [polypeptide binding]; other site 405535005993 anticodon binding site; other site 405535005994 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 405535005995 homodimer interface [polypeptide binding]; other site 405535005996 motif 1; other site 405535005997 motif 2; other site 405535005998 active site 405535005999 motif 3; other site 405535006000 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 405535006001 metal ion-dependent adhesion site (MIDAS); other site 405535006002 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 405535006003 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 405535006004 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 405535006005 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535006006 Walker A motif; other site 405535006007 ATP binding site [chemical binding]; other site 405535006008 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 405535006009 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 405535006010 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 405535006011 active site 405535006012 ATP binding site [chemical binding]; other site 405535006013 substrate binding site [chemical binding]; other site 405535006014 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535006015 binding surface 405535006016 TPR motif; other site 405535006017 TPR repeat; Region: TPR_11; pfam13414 405535006018 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535006019 binding surface 405535006020 TPR motif; other site 405535006021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535006022 binding surface 405535006023 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405535006024 TPR motif; other site 405535006025 SseB protein; Region: SseB; cl06279 405535006026 Proteins of 100 residues with WXG; Region: WXG100; cl02005 405535006027 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 405535006028 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 405535006029 Protein of unknown function, DUF600; Region: DUF600; cl04640 405535006030 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 405535006031 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 405535006032 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 405535006033 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 405535006034 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405535006035 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 405535006036 catalytic residues [active] 405535006037 catalytic nucleophile [active] 405535006038 Recombinase; Region: Recombinase; pfam07508 405535006039 Transposase; Region: DEDD_Tnp_IS110; pfam01548 405535006040 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 405535006041 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 405535006042 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 405535006043 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 405535006044 Protein of unknown function, DUF600; Region: DUF600; pfam04634 405535006045 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 405535006046 Immunity protein Imm3; Region: Imm3; pfam14425 405535006047 glycerate kinase; Region: TIGR00045 405535006048 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 405535006049 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 405535006050 transmembrane helices; other site 405535006051 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535006052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535006053 active site 405535006054 phosphorylation site [posttranslational modification] 405535006055 intermolecular recognition site; other site 405535006056 dimerization interface [polypeptide binding]; other site 405535006057 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535006058 DNA binding site [nucleotide binding] 405535006059 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535006060 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535006061 dimerization interface [polypeptide binding]; other site 405535006062 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535006063 dimer interface [polypeptide binding]; other site 405535006064 phosphorylation site [posttranslational modification] 405535006065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535006066 ATP binding site [chemical binding]; other site 405535006067 Mg2+ binding site [ion binding]; other site 405535006068 G-X-G motif; other site 405535006069 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 405535006070 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 405535006071 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 405535006072 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 405535006073 Na2 binding site [ion binding]; other site 405535006074 putative substrate binding site 1 [chemical binding]; other site 405535006075 Na binding site 1 [ion binding]; other site 405535006076 putative substrate binding site 2 [chemical binding]; other site 405535006077 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405535006078 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 405535006079 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 405535006080 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 405535006081 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535006082 motif II; other site 405535006083 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 405535006084 fructuronate transporter; Provisional; Region: PRK10034; cl15264 405535006085 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 405535006086 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 405535006087 active site 405535006088 NAD binding site [chemical binding]; other site 405535006089 metal binding site [ion binding]; metal-binding site 405535006090 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 405535006091 aspartate racemase; Region: asp_race; TIGR00035 405535006092 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 405535006093 homodimer interaction site [polypeptide binding]; other site 405535006094 cofactor binding site; other site 405535006095 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405535006096 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535006097 Coenzyme A binding pocket [chemical binding]; other site 405535006098 hypothetical protein; Validated; Region: PRK06769 405535006099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535006100 active site 405535006101 motif I; other site 405535006102 motif II; other site 405535006103 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405535006104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535006105 Coenzyme A binding pocket [chemical binding]; other site 405535006106 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405535006107 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405535006108 Walker A/P-loop; other site 405535006109 ATP binding site [chemical binding]; other site 405535006110 Q-loop/lid; other site 405535006111 ABC transporter signature motif; other site 405535006112 Walker B; other site 405535006113 D-loop; other site 405535006114 H-loop/switch region; other site 405535006115 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 405535006116 YpjP-like protein; Region: YpjP; pfam14005 405535006117 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 405535006118 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535006119 motif II; other site 405535006120 hypothetical protein; Provisional; Region: PRK06724 405535006121 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405535006122 active site 405535006123 metal binding site [ion binding]; metal-binding site 405535006124 Phosphotransferase enzyme family; Region: APH; pfam01636 405535006125 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 405535006126 active site 405535006127 substrate binding site [chemical binding]; other site 405535006128 ATP binding site [chemical binding]; other site 405535006129 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405535006130 Beta-lactamase; Region: Beta-lactamase; pfam00144 405535006131 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 405535006132 thymidylate synthase; Region: thym_sym; TIGR03284 405535006133 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 405535006134 dimerization interface [polypeptide binding]; other site 405535006135 active site 405535006136 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 405535006137 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 405535006138 folate binding site [chemical binding]; other site 405535006139 NADP+ binding site [chemical binding]; other site 405535006140 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 405535006141 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405535006142 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 405535006143 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405535006144 azoreductase; Reviewed; Region: PRK00170 405535006145 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405535006146 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 405535006147 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 405535006148 putative acyl-acceptor binding pocket; other site 405535006149 Haemolysin-III related; Region: HlyIII; cl03831 405535006150 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 405535006151 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 405535006152 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 405535006153 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 405535006154 EDD domain protein, DegV family; Region: DegV; TIGR00762 405535006155 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 405535006156 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 405535006157 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 405535006158 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 405535006159 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 405535006160 Cu(I) binding site [ion binding]; other site 405535006161 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 405535006162 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 405535006163 putative dimer interface [polypeptide binding]; other site 405535006164 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 405535006165 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 405535006166 active site 405535006167 dimer interface [polypeptide binding]; other site 405535006168 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 405535006169 Ligand Binding Site [chemical binding]; other site 405535006170 Molecular Tunnel; other site 405535006171 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405535006172 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405535006173 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 405535006174 siderophore binding site; other site 405535006175 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 405535006176 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 405535006177 homodimer interface [polypeptide binding]; other site 405535006178 substrate-cofactor binding pocket; other site 405535006179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535006180 catalytic residue [active] 405535006181 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 405535006182 FMN binding site [chemical binding]; other site 405535006183 dimer interface [polypeptide binding]; other site 405535006184 Isochorismatase family; Region: Isochorismatase; pfam00857 405535006185 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 405535006186 catalytic triad [active] 405535006187 conserved cis-peptide bond; other site 405535006188 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 405535006189 nudix motif; other site 405535006190 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 405535006191 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 405535006192 putative dimer interface [polypeptide binding]; other site 405535006193 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 405535006194 Mechanosensitive ion channel; Region: MS_channel; pfam00924 405535006195 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 405535006196 GAF domain; Region: GAF; pfam01590 405535006197 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405535006198 Histidine kinase; Region: HisKA_3; pfam07730 405535006199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535006200 ATP binding site [chemical binding]; other site 405535006201 Mg2+ binding site [ion binding]; other site 405535006202 G-X-G motif; other site 405535006203 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405535006204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535006205 active site 405535006206 phosphorylation site [posttranslational modification] 405535006207 intermolecular recognition site; other site 405535006208 dimerization interface [polypeptide binding]; other site 405535006209 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405535006210 DNA binding residues [nucleotide binding] 405535006211 dimerization interface [polypeptide binding]; other site 405535006212 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 405535006213 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 405535006214 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 405535006215 putative active site [active] 405535006216 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 405535006217 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 405535006218 NAD binding site [chemical binding]; other site 405535006219 substrate binding site [chemical binding]; other site 405535006220 catalytic Zn binding site [ion binding]; other site 405535006221 tetramer interface [polypeptide binding]; other site 405535006222 structural Zn binding site [ion binding]; other site 405535006223 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405535006224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535006225 dimer interface [polypeptide binding]; other site 405535006226 conserved gate region; other site 405535006227 ABC-ATPase subunit interface; other site 405535006228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 405535006229 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405535006230 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405535006231 Beta-lactamase; Region: Beta-lactamase; pfam00144 405535006232 Erythromycin esterase; Region: Erythro_esteras; pfam05139 405535006233 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 405535006234 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 405535006235 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405535006236 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405535006237 active site 405535006238 Predicted flavoprotein [General function prediction only]; Region: COG0431 405535006239 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405535006240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535006241 H+ Antiporter protein; Region: 2A0121; TIGR00900 405535006242 putative substrate translocation pore; other site 405535006243 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 405535006244 Uncharacterized conserved protein [Function unknown]; Region: COG1434 405535006245 putative active site [active] 405535006246 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 405535006247 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 405535006248 Walker A/P-loop; other site 405535006249 ATP binding site [chemical binding]; other site 405535006250 Q-loop/lid; other site 405535006251 ABC transporter signature motif; other site 405535006252 Walker B; other site 405535006253 D-loop; other site 405535006254 H-loop/switch region; other site 405535006255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535006256 dimer interface [polypeptide binding]; other site 405535006257 conserved gate region; other site 405535006258 ABC-ATPase subunit interface; other site 405535006259 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 405535006260 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 405535006261 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 405535006262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 405535006263 Protein of unknown function (DUF524); Region: DUF524; pfam04411 405535006264 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 405535006265 Helix-turn-helix domain; Region: HTH_17; cl17695 405535006266 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 405535006267 Domain of unknown function DUF21; Region: DUF21; pfam01595 405535006268 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 405535006269 Transporter associated domain; Region: CorC_HlyC; smart01091 405535006270 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 405535006271 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 405535006272 NAD(P) binding site [chemical binding]; other site 405535006273 catalytic residues [active] 405535006274 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 405535006275 Histidine kinase N terminal; Region: HisK_N; pfam09385 405535006276 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535006277 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535006278 dimer interface [polypeptide binding]; other site 405535006279 phosphorylation site [posttranslational modification] 405535006280 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535006281 ATP binding site [chemical binding]; other site 405535006282 Mg2+ binding site [ion binding]; other site 405535006283 G-X-G motif; other site 405535006284 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 405535006285 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 405535006286 hypothetical protein; Provisional; Region: PRK06917 405535006287 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405535006288 inhibitor-cofactor binding pocket; inhibition site 405535006289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535006290 catalytic residue [active] 405535006291 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 405535006292 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 405535006293 acetylornithine deacetylase; Validated; Region: PRK06915 405535006294 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 405535006295 metal binding site [ion binding]; metal-binding site 405535006296 dimer interface [polypeptide binding]; other site 405535006297 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 405535006298 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405535006299 PAS fold; Region: PAS_4; pfam08448 405535006300 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 405535006301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535006302 Walker A motif; other site 405535006303 ATP binding site [chemical binding]; other site 405535006304 Walker B motif; other site 405535006305 arginine finger; other site 405535006306 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405535006307 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 405535006308 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405535006309 FeS/SAM binding site; other site 405535006310 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 405535006311 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 405535006312 toxin interface [polypeptide binding]; other site 405535006313 Zn binding site [ion binding]; other site 405535006314 hypothetical protein; Provisional; Region: PRK13672 405535006315 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 405535006316 YozD-like protein; Region: YozD; pfam14162 405535006317 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 405535006318 Catalytic domain of Protein Kinases; Region: PKc; cd00180 405535006319 active site 405535006320 ATP binding site [chemical binding]; other site 405535006321 substrate binding site [chemical binding]; other site 405535006322 activation loop (A-loop); other site 405535006323 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 405535006324 SpoOM protein; Region: Spo0M; pfam07070 405535006325 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405535006326 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 405535006327 active site 405535006328 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 405535006329 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 405535006330 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405535006331 catalytic residues [active] 405535006332 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405535006333 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 405535006334 DNA binding site [nucleotide binding] 405535006335 active site 405535006336 Int/Topo IB signature motif; other site 405535006337 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 405535006338 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 405535006339 S-layer homology domain; Region: SLH; pfam00395 405535006340 S-layer homology domain; Region: SLH; pfam00395 405535006341 S-layer homology domain; Region: SLH; pfam00395 405535006342 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 405535006343 putative active site [active] 405535006344 catalytic site [active] 405535006345 Restriction endonuclease; Region: Mrr_cat; pfam04471 405535006346 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535006347 non-specific DNA binding site [nucleotide binding]; other site 405535006348 salt bridge; other site 405535006349 sequence-specific DNA binding site [nucleotide binding]; other site 405535006350 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 405535006351 Replication-relaxation; Region: Replic_Relax; pfam13814 405535006352 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 405535006353 homotrimer interaction site [polypeptide binding]; other site 405535006354 putative active site [active] 405535006355 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 405535006356 CHRD domain; Region: CHRD; pfam07452 405535006357 C1q domain; Region: C1q; cl17543 405535006358 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 405535006359 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 405535006360 YolD-like protein; Region: YolD; pfam08863 405535006361 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 405535006362 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 405535006363 Transglycosylase; Region: Transgly; pfam00912 405535006364 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 405535006365 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405535006366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535006367 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405535006368 putative substrate translocation pore; other site 405535006369 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 405535006370 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 405535006371 dimer interface [polypeptide binding]; other site 405535006372 Citrate synthase; Region: Citrate_synt; pfam00285 405535006373 active site 405535006374 coenzyme A binding site [chemical binding]; other site 405535006375 citrylCoA binding site [chemical binding]; other site 405535006376 oxalacetate/citrate binding site [chemical binding]; other site 405535006377 catalytic triad [active] 405535006378 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 405535006379 2-methylcitrate dehydratase; Region: prpD; TIGR02330 405535006380 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 405535006381 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 405535006382 tetramer interface [polypeptide binding]; other site 405535006383 active site 405535006384 Mg2+/Mn2+ binding site [ion binding]; other site 405535006385 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 405535006386 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405535006387 active site 405535006388 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 405535006389 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405535006390 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 405535006391 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 405535006392 tetrameric interface [polypeptide binding]; other site 405535006393 NAD binding site [chemical binding]; other site 405535006394 catalytic residues [active] 405535006395 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 405535006396 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 405535006397 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405535006398 substrate binding site [chemical binding]; other site 405535006399 oxyanion hole (OAH) forming residues; other site 405535006400 trimer interface [polypeptide binding]; other site 405535006401 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 405535006402 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 405535006403 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 405535006404 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 405535006405 active site 405535006406 metal binding site [ion binding]; metal-binding site 405535006407 DNA binding site [nucleotide binding] 405535006408 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 405535006409 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 405535006410 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 405535006411 Walker A/P-loop; other site 405535006412 ATP binding site [chemical binding]; other site 405535006413 Q-loop/lid; other site 405535006414 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 405535006415 ABC transporter signature motif; other site 405535006416 Walker B; other site 405535006417 D-loop; other site 405535006418 H-loop/switch region; other site 405535006419 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535006420 dimerization interface [polypeptide binding]; other site 405535006421 putative DNA binding site [nucleotide binding]; other site 405535006422 putative Zn2+ binding site [ion binding]; other site 405535006423 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 405535006424 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 405535006425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535006426 putative substrate translocation pore; other site 405535006427 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 405535006428 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 405535006429 putative NAD(P) binding site [chemical binding]; other site 405535006430 active site 405535006431 isochorismate synthase DhbC; Validated; Region: PRK06923 405535006432 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 405535006433 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 405535006434 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 405535006435 acyl-activating enzyme (AAE) consensus motif; other site 405535006436 active site 405535006437 AMP binding site [chemical binding]; other site 405535006438 substrate binding site [chemical binding]; other site 405535006439 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 405535006440 hydrophobic substrate binding pocket; other site 405535006441 Isochorismatase family; Region: Isochorismatase; pfam00857 405535006442 active site 405535006443 conserved cis-peptide bond; other site 405535006444 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 405535006445 Condensation domain; Region: Condensation; pfam00668 405535006446 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 405535006447 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 405535006448 acyl-activating enzyme (AAE) consensus motif; other site 405535006449 AMP binding site [chemical binding]; other site 405535006450 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405535006451 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 405535006452 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 405535006453 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405535006454 acyl-activating enzyme (AAE) consensus motif; other site 405535006455 AMP binding site [chemical binding]; other site 405535006456 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405535006457 MbtH-like protein; Region: MbtH; cl01279 405535006458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535006459 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405535006460 putative substrate translocation pore; other site 405535006461 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 405535006462 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 405535006463 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 405535006464 IHF dimer interface [polypeptide binding]; other site 405535006465 IHF - DNA interface [nucleotide binding]; other site 405535006466 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 405535006467 DinB family; Region: DinB; cl17821 405535006468 DinB superfamily; Region: DinB_2; pfam12867 405535006469 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 405535006470 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 405535006471 active site 405535006472 catalytic triad [active] 405535006473 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405535006474 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 405535006475 Glycine riboswitch 405535006476 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 405535006477 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405535006478 RNA binding surface [nucleotide binding]; other site 405535006479 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 405535006480 probable active site [active] 405535006481 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 405535006482 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 405535006483 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 405535006484 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 405535006485 active site 405535006486 dimer interface [polypeptide binding]; other site 405535006487 motif 1; other site 405535006488 motif 2; other site 405535006489 motif 3; other site 405535006490 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 405535006491 anticodon binding site; other site 405535006492 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405535006493 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405535006494 Walker A/P-loop; other site 405535006495 ATP binding site [chemical binding]; other site 405535006496 Q-loop/lid; other site 405535006497 ABC transporter signature motif; other site 405535006498 Walker B; other site 405535006499 D-loop; other site 405535006500 H-loop/switch region; other site 405535006501 FtsX-like permease family; Region: FtsX; pfam02687 405535006502 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405535006503 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405535006504 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405535006505 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 405535006506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 405535006507 ABC-ATPase subunit interface; other site 405535006508 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 405535006509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535006510 S-adenosylmethionine binding site [chemical binding]; other site 405535006511 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405535006512 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 405535006513 active site 405535006514 dimerization interface [polypeptide binding]; other site 405535006515 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 405535006516 Protein of unknown function, DUF606; Region: DUF606; pfam04657 405535006517 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 405535006518 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405535006519 ligand binding site [chemical binding]; other site 405535006520 flexible hinge region; other site 405535006521 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 405535006522 Protein of unknown function, DUF606; Region: DUF606; pfam04657 405535006523 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 405535006524 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405535006525 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535006526 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535006527 MMPL family; Region: MMPL; pfam03176 405535006528 MMPL family; Region: MMPL; pfam03176 405535006529 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 405535006530 Chloramphenicol acetyltransferase; Region: CAT; pfam00302 405535006531 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 405535006532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535006533 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405535006534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405535006535 Coenzyme A binding pocket [chemical binding]; other site 405535006536 potential frameshift: common BLAST hit: gi|49185256|ref|YP_028508.1| acetyltransferase 405535006537 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405535006538 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535006539 Coenzyme A binding pocket [chemical binding]; other site 405535006540 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 405535006541 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 405535006542 putative acetyltransferase YhhY; Provisional; Region: PRK10140 405535006543 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535006544 Coenzyme A binding pocket [chemical binding]; other site 405535006545 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405535006546 EamA-like transporter family; Region: EamA; pfam00892 405535006547 EamA-like transporter family; Region: EamA; pfam00892 405535006548 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 405535006549 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535006550 non-specific DNA binding site [nucleotide binding]; other site 405535006551 salt bridge; other site 405535006552 sequence-specific DNA binding site [nucleotide binding]; other site 405535006553 Cupin domain; Region: Cupin_2; pfam07883 405535006554 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 405535006555 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405535006556 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405535006557 protoporphyrinogen oxidase; Provisional; Region: PRK12416 405535006558 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405535006559 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405535006560 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405535006561 Cold-inducible protein YdjO; Region: YdjO; pfam14169 405535006562 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405535006563 DNA-binding site [nucleotide binding]; DNA binding site 405535006564 RNA-binding motif; other site 405535006565 CAAX protease self-immunity; Region: Abi; pfam02517 405535006566 AAA domain; Region: AAA_17; pfam13207 405535006567 AAA domain; Region: AAA_18; pfam13238 405535006568 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 405535006569 active site 405535006570 metal binding site [ion binding]; metal-binding site 405535006571 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535006572 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405535006573 active site 405535006574 motif I; other site 405535006575 motif II; other site 405535006576 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535006577 motif II; other site 405535006578 hypothetical protein; Provisional; Region: PRK06770 405535006579 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 405535006580 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 405535006581 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405535006582 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405535006583 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405535006584 dimerization interface [polypeptide binding]; other site 405535006585 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 405535006586 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 405535006587 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 405535006588 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 405535006589 active site 405535006590 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 405535006591 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 405535006592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405535006593 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405535006594 dimerization interface [polypeptide binding]; other site 405535006595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 405535006596 MOSC domain; Region: MOSC; pfam03473 405535006597 3-alpha domain; Region: 3-alpha; pfam03475 405535006598 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535006599 Coenzyme A binding pocket [chemical binding]; other site 405535006600 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 405535006601 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405535006602 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405535006603 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535006604 Walker A/P-loop; other site 405535006605 ATP binding site [chemical binding]; other site 405535006606 Q-loop/lid; other site 405535006607 ABC transporter signature motif; other site 405535006608 Walker B; other site 405535006609 D-loop; other site 405535006610 H-loop/switch region; other site 405535006611 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405535006612 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405535006613 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 405535006614 Walker A/P-loop; other site 405535006615 ATP binding site [chemical binding]; other site 405535006616 Q-loop/lid; other site 405535006617 ABC transporter signature motif; other site 405535006618 Walker B; other site 405535006619 D-loop; other site 405535006620 H-loop/switch region; other site 405535006621 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405535006622 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 405535006623 active site 405535006624 metal binding site [ion binding]; metal-binding site 405535006625 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 405535006626 LysE type translocator; Region: LysE; cl00565 405535006627 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 405535006628 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535006629 non-specific DNA binding site [nucleotide binding]; other site 405535006630 salt bridge; other site 405535006631 sequence-specific DNA binding site [nucleotide binding]; other site 405535006632 Cupin domain; Region: Cupin_2; pfam07883 405535006633 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 405535006634 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 405535006635 BclB C-terminal domain; Region: exospore_TM; TIGR03721 405535006636 Cupin; Region: Cupin_1; smart00835 405535006637 HD domain; Region: HD_4; pfam13328 405535006638 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 405535006639 metal binding triad [ion binding]; metal-binding site 405535006640 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 405535006641 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 405535006642 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405535006643 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 405535006644 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535006645 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 405535006646 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405535006647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535006648 S-adenosylmethionine binding site [chemical binding]; other site 405535006649 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 405535006650 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 405535006651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 405535006652 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 405535006653 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 405535006654 active site 405535006655 P-loop; other site 405535006656 phosphorylation site [posttranslational modification] 405535006657 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 405535006658 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 405535006659 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 405535006660 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 405535006661 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405535006662 nucleotide binding site [chemical binding]; other site 405535006663 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 405535006664 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 405535006665 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 405535006666 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405535006667 catalytic residue [active] 405535006668 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 405535006669 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 405535006670 tetramer interface [polypeptide binding]; other site 405535006671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535006672 catalytic residue [active] 405535006673 Uncharacterized conserved protein [Function unknown]; Region: COG3339 405535006674 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 405535006675 Proteins of 100 residues with WXG; Region: WXG100; cl02005 405535006676 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 405535006677 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 405535006678 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 405535006679 ATP binding site [chemical binding]; other site 405535006680 Mg++ binding site [ion binding]; other site 405535006681 motif III; other site 405535006682 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405535006683 nucleotide binding region [chemical binding]; other site 405535006684 ATP-binding site [chemical binding]; other site 405535006685 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535006686 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535006687 H+ Antiporter protein; Region: 2A0121; TIGR00900 405535006688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535006689 putative substrate translocation pore; other site 405535006690 FtsX-like permease family; Region: FtsX; pfam02687 405535006691 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405535006692 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405535006693 Walker A/P-loop; other site 405535006694 ATP binding site [chemical binding]; other site 405535006695 Q-loop/lid; other site 405535006696 ABC transporter signature motif; other site 405535006697 Walker B; other site 405535006698 D-loop; other site 405535006699 H-loop/switch region; other site 405535006700 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405535006701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535006702 S-adenosylmethionine binding site [chemical binding]; other site 405535006703 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 405535006704 dimer interface [polypeptide binding]; other site 405535006705 cell division protein FtsZ; Region: ftsZ; TIGR00065 405535006706 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 405535006707 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 405535006708 dimer interface [polypeptide binding]; other site 405535006709 PYR/PP interface [polypeptide binding]; other site 405535006710 TPP binding site [chemical binding]; other site 405535006711 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405535006712 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 405535006713 TPP-binding site [chemical binding]; other site 405535006714 dimer interface [polypeptide binding]; other site 405535006715 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405535006716 MarR family; Region: MarR_2; pfam12802 405535006717 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405535006718 catalytic core [active] 405535006719 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 405535006720 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 405535006721 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 405535006722 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 405535006723 metal binding site [ion binding]; metal-binding site 405535006724 dimer interface [polypeptide binding]; other site 405535006725 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 405535006726 active site 405535006727 catalytic triad [active] 405535006728 oxyanion hole [active] 405535006729 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 405535006730 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535006731 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405535006732 DNA binding residues [nucleotide binding] 405535006733 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 405535006734 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405535006735 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405535006736 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 405535006737 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405535006738 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405535006739 beta-lactamase TEM; Provisional; Region: PRK15442 405535006740 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 405535006741 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 405535006742 active site 405535006743 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405535006744 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405535006745 DNA binding site [nucleotide binding] 405535006746 domain linker motif; other site 405535006747 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 405535006748 ligand binding site [chemical binding]; other site 405535006749 dimerization interface [polypeptide binding]; other site 405535006750 polyol permease family; Region: 2A0118; TIGR00897 405535006751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535006752 putative substrate translocation pore; other site 405535006753 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405535006754 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 405535006755 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 405535006756 potential frameshift: common BLAST hit: gi|49185342|ref|YP_028594.1| iolC protein, putative 405535006757 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 405535006758 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405535006759 substrate binding site [chemical binding]; other site 405535006760 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405535006761 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 405535006762 ATP binding site [chemical binding]; other site 405535006763 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 405535006764 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 405535006765 tetrameric interface [polypeptide binding]; other site 405535006766 NAD binding site [chemical binding]; other site 405535006767 catalytic residues [active] 405535006768 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 405535006769 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 405535006770 PYR/PP interface [polypeptide binding]; other site 405535006771 dimer interface [polypeptide binding]; other site 405535006772 TPP binding site [chemical binding]; other site 405535006773 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405535006774 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 405535006775 TPP-binding site; other site 405535006776 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 405535006777 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 405535006778 intersubunit interface [polypeptide binding]; other site 405535006779 active site 405535006780 zinc binding site [ion binding]; other site 405535006781 Na+ binding site [ion binding]; other site 405535006782 KduI/IolB family; Region: KduI; pfam04962 405535006783 DinB superfamily; Region: DinB_2; pfam12867 405535006784 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 405535006785 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 405535006786 active site 405535006787 metal binding site [ion binding]; metal-binding site 405535006788 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405535006789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535006790 TPR motif; other site 405535006791 binding surface 405535006792 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405535006793 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535006794 salt bridge; other site 405535006795 non-specific DNA binding site [nucleotide binding]; other site 405535006796 sequence-specific DNA binding site [nucleotide binding]; other site 405535006797 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 405535006798 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 405535006799 S-layer homology domain; Region: SLH; pfam00395 405535006800 S-layer homology domain; Region: SLH; pfam00395 405535006801 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 405535006802 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405535006803 active site 405535006804 metal binding site [ion binding]; metal-binding site 405535006805 beta-channel forming cytolysin; Region: hlyII; TIGR01002 405535006806 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535006807 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535006808 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405535006809 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405535006810 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405535006811 PAS fold; Region: PAS_4; pfam08448 405535006812 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405535006813 putative active site [active] 405535006814 heme pocket [chemical binding]; other site 405535006815 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405535006816 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405535006817 metal binding site [ion binding]; metal-binding site 405535006818 active site 405535006819 I-site; other site 405535006820 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405535006821 Homeodomain-like domain; Region: HTH_23; cl17451 405535006822 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 405535006823 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405535006824 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 405535006825 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405535006826 active site residue [active] 405535006827 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405535006828 active site residue [active] 405535006829 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 405535006830 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405535006831 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405535006832 Walker A/P-loop; other site 405535006833 ATP binding site [chemical binding]; other site 405535006834 Q-loop/lid; other site 405535006835 ABC transporter signature motif; other site 405535006836 Walker B; other site 405535006837 D-loop; other site 405535006838 H-loop/switch region; other site 405535006839 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 405535006840 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 405535006841 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535006842 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535006843 Protein of unknown function (DUF523); Region: DUF523; pfam04463 405535006844 Uncharacterized conserved protein [Function unknown]; Region: COG3272 405535006845 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 405535006846 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405535006847 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 405535006848 FAD binding site [chemical binding]; other site 405535006849 homotetramer interface [polypeptide binding]; other site 405535006850 substrate binding pocket [chemical binding]; other site 405535006851 catalytic base [active] 405535006852 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 405535006853 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405535006854 ATP-grasp domain; Region: ATP-grasp_4; cl17255 405535006855 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 405535006856 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 405535006857 carboxyltransferase (CT) interaction site; other site 405535006858 biotinylation site [posttranslational modification]; other site 405535006859 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 405535006860 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 405535006861 active site 405535006862 catalytic residues [active] 405535006863 metal binding site [ion binding]; metal-binding site 405535006864 enoyl-CoA hydratase; Provisional; Region: PRK07657 405535006865 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405535006866 substrate binding site [chemical binding]; other site 405535006867 oxyanion hole (OAH) forming residues; other site 405535006868 trimer interface [polypeptide binding]; other site 405535006869 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 405535006870 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 405535006871 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 405535006872 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 405535006873 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 405535006874 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 405535006875 acyl-activating enzyme (AAE) consensus motif; other site 405535006876 putative AMP binding site [chemical binding]; other site 405535006877 putative active site [active] 405535006878 putative CoA binding site [chemical binding]; other site 405535006879 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405535006880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535006881 Coenzyme A binding pocket [chemical binding]; other site 405535006882 hypothetical protein; Provisional; Region: PRK08233 405535006883 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 405535006884 active site 405535006885 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405535006886 DinB family; Region: DinB; cl17821 405535006887 DinB superfamily; Region: DinB_2; pfam12867 405535006888 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 405535006889 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405535006890 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535006891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535006892 dimer interface [polypeptide binding]; other site 405535006893 phosphorylation site [posttranslational modification] 405535006894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535006895 ATP binding site [chemical binding]; other site 405535006896 Mg2+ binding site [ion binding]; other site 405535006897 G-X-G motif; other site 405535006898 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535006899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535006900 active site 405535006901 phosphorylation site [posttranslational modification] 405535006902 intermolecular recognition site; other site 405535006903 dimerization interface [polypeptide binding]; other site 405535006904 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535006905 DNA binding site [nucleotide binding] 405535006906 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405535006907 Zn2+ binding site [ion binding]; other site 405535006908 Mg2+ binding site [ion binding]; other site 405535006909 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 405535006910 S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714 405535006911 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 405535006912 NADH(P)-binding; Region: NAD_binding_10; pfam13460 405535006913 NAD binding site [chemical binding]; other site 405535006914 substrate binding site [chemical binding]; other site 405535006915 putative active site [active] 405535006916 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535006917 Coenzyme A binding pocket [chemical binding]; other site 405535006918 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535006919 Coenzyme A binding pocket [chemical binding]; other site 405535006920 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405535006921 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405535006922 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 405535006923 active site 405535006924 Zn binding site [ion binding]; other site 405535006925 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 405535006926 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 405535006927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 405535006928 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 405535006929 putative hydrophobic ligand binding site [chemical binding]; other site 405535006930 Predicted transcriptional regulators [Transcription]; Region: COG1695 405535006931 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405535006932 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405535006933 Beta-lactamase; Region: Beta-lactamase; pfam00144 405535006934 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 405535006935 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405535006936 DNA binding residues [nucleotide binding] 405535006937 drug binding residues [chemical binding]; other site 405535006938 dimer interface [polypeptide binding]; other site 405535006939 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 405535006940 H+ Antiporter protein; Region: 2A0121; TIGR00900 405535006941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535006942 putative substrate translocation pore; other site 405535006943 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405535006944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535006945 S-adenosylmethionine binding site [chemical binding]; other site 405535006946 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 405535006947 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405535006948 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 405535006949 Phosphotransferase enzyme family; Region: APH; pfam01636 405535006950 active site 405535006951 substrate binding site [chemical binding]; other site 405535006952 ATP binding site [chemical binding]; other site 405535006953 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405535006954 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405535006955 Phosphotransferase enzyme family; Region: APH; pfam01636 405535006956 active site 405535006957 substrate binding site [chemical binding]; other site 405535006958 ATP binding site [chemical binding]; other site 405535006959 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 405535006960 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 405535006961 active site 405535006962 Zn binding site [ion binding]; other site 405535006963 potential frameshift: common BLAST hit: gi|49185416|ref|YP_028668.1| putative lipoprotein 405535006964 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 405535006965 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405535006966 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535006967 DNA-binding site [nucleotide binding]; DNA binding site 405535006968 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405535006969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535006970 homodimer interface [polypeptide binding]; other site 405535006971 catalytic residue [active] 405535006972 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 405535006973 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 405535006974 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 405535006975 Alcohol dehydrogenase GroES-like domain; Region: ADH_N; pfam08240 405535006976 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 405535006977 putative NAD(P) binding site [chemical binding]; other site 405535006978 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405535006979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535006980 S-adenosylmethionine binding site [chemical binding]; other site 405535006981 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 405535006982 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 405535006983 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405535006984 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405535006985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535006986 S-adenosylmethionine binding site [chemical binding]; other site 405535006987 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 405535006988 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 405535006989 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535006990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535006991 active site 405535006992 phosphorylation site [posttranslational modification] 405535006993 intermolecular recognition site; other site 405535006994 dimerization interface [polypeptide binding]; other site 405535006995 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535006996 DNA binding site [nucleotide binding] 405535006997 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535006998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 405535006999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535007000 ATP binding site [chemical binding]; other site 405535007001 Mg2+ binding site [ion binding]; other site 405535007002 G-X-G motif; other site 405535007003 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 405535007004 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405535007005 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405535007006 ABC transporter; Region: ABC_tran_2; pfam12848 405535007007 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405535007008 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405535007009 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405535007010 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 405535007011 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405535007012 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405535007013 Walker A/P-loop; other site 405535007014 ATP binding site [chemical binding]; other site 405535007015 Q-loop/lid; other site 405535007016 ABC transporter signature motif; other site 405535007017 Walker B; other site 405535007018 D-loop; other site 405535007019 H-loop/switch region; other site 405535007020 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405535007021 FtsX-like permease family; Region: FtsX; pfam02687 405535007022 hypothetical protein; Provisional; Region: PRK06760 405535007023 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 405535007024 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 405535007025 homoserine dehydrogenase; Validated; Region: PRK06813 405535007026 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 405535007027 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 405535007028 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405535007029 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535007030 DNA-binding site [nucleotide binding]; DNA binding site 405535007031 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405535007032 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535007033 homodimer interface [polypeptide binding]; other site 405535007034 catalytic residue [active] 405535007035 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 405535007036 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 405535007037 ATP-grasp domain; Region: ATP-grasp_4; cl17255 405535007038 Putative transcription activator [Transcription]; Region: TenA; COG0819 405535007039 potential frameshift: common BLAST hit: gi|52142883|ref|YP_083947.1| group-specific protein 405535007040 ERCC4-like helicases [DNA replication, recombination, and repair]; Region: MPH1; COG1111 405535007041 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 405535007042 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 405535007043 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105 405535007044 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 405535007045 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 405535007046 Protein of unknown function; Region: DUF3658; pfam12395 405535007047 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 405535007048 Cytochrome P450; Region: p450; cl12078 405535007049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535007050 H+ Antiporter protein; Region: 2A0121; TIGR00900 405535007051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535007052 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 405535007053 trimer interface [polypeptide binding]; other site 405535007054 active site 405535007055 substrate binding site [chemical binding]; other site 405535007056 CoA binding site [chemical binding]; other site 405535007057 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 405535007058 Predicted transcriptional regulators [Transcription]; Region: COG1695 405535007059 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405535007060 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 405535007061 Cytochrome P450; Region: p450; cl12078 405535007062 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 405535007063 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535007064 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405535007065 active site 405535007066 motif I; other site 405535007067 motif II; other site 405535007068 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535007069 PAS domain S-box; Region: sensory_box; TIGR00229 405535007070 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405535007071 putative active site [active] 405535007072 heme pocket [chemical binding]; other site 405535007073 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 405535007074 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535007075 dimer interface [polypeptide binding]; other site 405535007076 phosphorylation site [posttranslational modification] 405535007077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535007078 ATP binding site [chemical binding]; other site 405535007079 Mg2+ binding site [ion binding]; other site 405535007080 G-X-G motif; other site 405535007081 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405535007082 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405535007083 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405535007084 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405535007085 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 405535007086 glycosyltransferase, MGT family; Region: MGT; TIGR01426 405535007087 active site 405535007088 TDP-binding site; other site 405535007089 acceptor substrate-binding pocket; other site 405535007090 homodimer interface [polypeptide binding]; other site 405535007091 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 405535007092 aspartate racemase; Region: asp_race; TIGR00035 405535007093 hypothetical protein; Provisional; Region: PRK13661 405535007094 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 405535007095 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405535007096 Walker A/P-loop; other site 405535007097 ATP binding site [chemical binding]; other site 405535007098 Q-loop/lid; other site 405535007099 ABC transporter signature motif; other site 405535007100 Walker B; other site 405535007101 D-loop; other site 405535007102 H-loop/switch region; other site 405535007103 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 405535007104 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405535007105 Walker A/P-loop; other site 405535007106 ATP binding site [chemical binding]; other site 405535007107 Q-loop/lid; other site 405535007108 ABC transporter signature motif; other site 405535007109 Walker B; other site 405535007110 D-loop; other site 405535007111 H-loop/switch region; other site 405535007112 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 405535007113 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 405535007114 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535007115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535007116 dimer interface [polypeptide binding]; other site 405535007117 phosphorylation site [posttranslational modification] 405535007118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535007119 ATP binding site [chemical binding]; other site 405535007120 Mg2+ binding site [ion binding]; other site 405535007121 G-X-G motif; other site 405535007122 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 405535007123 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 405535007124 active site 405535007125 ATP binding site [chemical binding]; other site 405535007126 substrate binding site [chemical binding]; other site 405535007127 activation loop (A-loop); other site 405535007128 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 405535007129 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405535007130 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 405535007131 NAD(P) binding site [chemical binding]; other site 405535007132 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 405535007133 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405535007134 active site 405535007135 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405535007136 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405535007137 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405535007138 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 405535007139 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 405535007140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535007141 H+ Antiporter protein; Region: 2A0121; TIGR00900 405535007142 putative substrate translocation pore; other site 405535007143 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405535007144 Beta-lactamase; Region: Beta-lactamase; pfam00144 405535007145 putative acetyltransferase; Provisional; Region: PRK03624 405535007146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535007147 Coenzyme A binding pocket [chemical binding]; other site 405535007148 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 405535007149 EDD domain protein, DegV family; Region: DegV; TIGR00762 405535007150 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 405535007151 Putative amidotransferase; Region: DUF4066; pfam13278 405535007152 conserved cys residue [active] 405535007153 Predicted transcriptional regulator [Transcription]; Region: COG2378 405535007154 HTH domain; Region: HTH_11; pfam08279 405535007155 WYL domain; Region: WYL; pfam13280 405535007156 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 405535007157 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 405535007158 conserved cys residue [active] 405535007159 Protein of unknown function (DUF975); Region: DUF975; cl10504 405535007160 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405535007161 Beta-lactamase; Region: Beta-lactamase; pfam00144 405535007162 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777 405535007163 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405535007164 DNA binding residues [nucleotide binding] 405535007165 putative dimer interface [polypeptide binding]; other site 405535007166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535007167 S-adenosylmethionine binding site [chemical binding]; other site 405535007168 H+ Antiporter protein; Region: 2A0121; TIGR00900 405535007169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535007170 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 405535007171 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535007172 Coenzyme A binding pocket [chemical binding]; other site 405535007173 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 405535007174 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 405535007175 active site 405535007176 catalytic site [active] 405535007177 metal binding site [ion binding]; metal-binding site 405535007178 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 405535007179 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405535007180 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535007181 DNA-binding site [nucleotide binding]; DNA binding site 405535007182 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405535007183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535007184 homodimer interface [polypeptide binding]; other site 405535007185 catalytic residue [active] 405535007186 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405535007187 EamA-like transporter family; Region: EamA; pfam00892 405535007188 EamA-like transporter family; Region: EamA; pfam00892 405535007189 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 405535007190 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 405535007191 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535007192 Coenzyme A binding pocket [chemical binding]; other site 405535007193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 405535007194 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 405535007195 nudix motif; other site 405535007196 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 405535007197 Beta-lactamase; Region: Beta-lactamase; pfam00144 405535007198 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405535007199 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 405535007200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535007201 putative substrate translocation pore; other site 405535007202 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 405535007203 Cadmium resistance transporter; Region: Cad; pfam03596 405535007204 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535007205 Coenzyme A binding pocket [chemical binding]; other site 405535007206 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405535007207 nudix motif; other site 405535007208 DNA polymerase III subunit beta; Validated; Region: PRK06673 405535007209 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 405535007210 putative DNA binding surface [nucleotide binding]; other site 405535007211 dimer interface [polypeptide binding]; other site 405535007212 beta-clamp/clamp loader binding surface; other site 405535007213 beta-clamp/translesion DNA polymerase binding surface; other site 405535007214 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 405535007215 putative active site [active] 405535007216 nucleotide binding site [chemical binding]; other site 405535007217 nudix motif; other site 405535007218 putative metal binding site [ion binding]; other site 405535007219 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 405535007220 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405535007221 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 405535007222 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 405535007223 translation initiation factor IF-2; Provisional; Region: PRK14845 405535007224 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 405535007225 homotrimer interaction site [polypeptide binding]; other site 405535007226 putative active site [active] 405535007227 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 405535007228 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 405535007229 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 405535007230 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 405535007231 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 405535007232 YxiJ-like protein; Region: YxiJ; pfam14176 405535007233 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 405535007234 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 405535007235 active site 405535007236 nucleophile elbow; other site 405535007237 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 405535007238 pentamer interface [polypeptide binding]; other site 405535007239 dodecaamer interface [polypeptide binding]; other site 405535007240 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535007241 Coenzyme A binding pocket [chemical binding]; other site 405535007242 metal-dependent hydrolase; Provisional; Region: PRK13291 405535007243 DinB superfamily; Region: DinB_2; pfam12867 405535007244 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405535007245 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405535007246 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 405535007247 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 405535007248 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 405535007249 GIY-YIG motif/motif A; other site 405535007250 active site 405535007251 catalytic site [active] 405535007252 putative DNA binding site [nucleotide binding]; other site 405535007253 metal binding site [ion binding]; metal-binding site 405535007254 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405535007255 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535007256 Coenzyme A binding pocket [chemical binding]; other site 405535007257 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 405535007258 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 405535007259 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 405535007260 active site 405535007261 ATP binding site [chemical binding]; other site 405535007262 substrate binding site [chemical binding]; other site 405535007263 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 405535007264 nudix motif; other site 405535007265 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 405535007266 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405535007267 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 405535007268 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 405535007269 MepB protein; Region: MepB; pfam08877 405535007270 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 405535007271 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 405535007272 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 405535007273 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405535007274 tyrosine decarboxylase; Region: PLN02880 405535007275 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 405535007276 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405535007277 catalytic residue [active] 405535007278 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405535007279 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 405535007280 acyl-activating enzyme (AAE) consensus motif; other site 405535007281 AMP binding site [chemical binding]; other site 405535007282 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405535007283 Condensation domain; Region: Condensation; pfam00668 405535007284 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 405535007285 Nonribosomal peptide synthase; Region: NRPS; pfam08415 405535007286 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 405535007287 acyl-activating enzyme (AAE) consensus motif; other site 405535007288 AMP binding site [chemical binding]; other site 405535007289 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405535007290 Condensation domain; Region: Condensation; pfam00668 405535007291 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 405535007292 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 405535007293 putative FMN binding site [chemical binding]; other site 405535007294 NADPH bind site [chemical binding]; other site 405535007295 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 405535007296 carbohydrate binding site [chemical binding]; other site 405535007297 pullulanase, type I; Region: pulA_typeI; TIGR02104 405535007298 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 405535007299 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 405535007300 Ca binding site [ion binding]; other site 405535007301 active site 405535007302 catalytic site [active] 405535007303 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 405535007304 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405535007305 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405535007306 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 405535007307 active site 405535007308 Zn binding site [ion binding]; other site 405535007309 Putative zinc-finger; Region: zf-HC2; pfam13490 405535007310 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 405535007311 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 405535007312 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535007313 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405535007314 DNA binding residues [nucleotide binding] 405535007315 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 405535007316 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 405535007317 SecY translocase; Region: SecY; pfam00344 405535007318 hypothetical protein; Validated; Region: PRK06672 405535007319 DnaA N-terminal domain; Region: DnaA_N; pfam11638 405535007320 DnaA N-terminal domain; Region: DnaA_N; pfam11638 405535007321 DnaA N-terminal domain; Region: DnaA_N; pfam11638 405535007322 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 405535007323 EamA-like transporter family; Region: EamA; pfam00892 405535007324 EamA-like transporter family; Region: EamA; pfam00892 405535007325 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405535007326 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535007327 DNA-binding site [nucleotide binding]; DNA binding site 405535007328 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405535007329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535007330 homodimer interface [polypeptide binding]; other site 405535007331 catalytic residue [active] 405535007332 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405535007333 TAP-like protein; Region: Abhydrolase_4; pfam08386 405535007334 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 405535007335 Mg binding site [ion binding]; other site 405535007336 nucleotide binding site [chemical binding]; other site 405535007337 putative protofilament interface [polypeptide binding]; other site 405535007338 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 405535007339 Predicted membrane protein [Function unknown]; Region: COG4129 405535007340 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 405535007341 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405535007342 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 405535007343 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 405535007344 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 405535007345 germination protein YpeB; Region: spore_YpeB; TIGR02889 405535007346 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 405535007347 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 405535007348 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 405535007349 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 405535007350 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405535007351 Beta-lactamase; Region: Beta-lactamase; pfam00144 405535007352 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 405535007353 Putative cyclase; Region: Cyclase; cl00814 405535007354 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 405535007355 kynureninase; Region: kynureninase; TIGR01814 405535007356 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405535007357 catalytic residue [active] 405535007358 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535007359 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535007360 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 405535007361 nudix motif; other site 405535007362 N-acetyltransferase; Region: Acetyltransf_2; cl00949 405535007363 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 405535007364 hydrophobic ligand binding site; other site 405535007365 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 405535007366 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 405535007367 GAF domain; Region: GAF; pfam01590 405535007368 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535007369 Walker A motif; other site 405535007370 ATP binding site [chemical binding]; other site 405535007371 Walker B motif; other site 405535007372 arginine finger; other site 405535007373 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405535007374 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 405535007375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535007376 Coenzyme A binding pocket [chemical binding]; other site 405535007377 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 405535007378 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 405535007379 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405535007380 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 405535007381 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 405535007382 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405535007383 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405535007384 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405535007385 potential frameshift: common BLAST hit: gi|118478135|ref|YP_895286.1| branched-chain alpha-keto acid dehydrogenase subunit E2 405535007386 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 405535007387 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 405535007388 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405535007389 E3 interaction surface; other site 405535007390 lipoyl attachment site [posttranslational modification]; other site 405535007391 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 405535007392 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 405535007393 alpha subunit interface [polypeptide binding]; other site 405535007394 TPP binding site [chemical binding]; other site 405535007395 heterodimer interface [polypeptide binding]; other site 405535007396 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405535007397 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 405535007398 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 405535007399 tetramer interface [polypeptide binding]; other site 405535007400 TPP-binding site [chemical binding]; other site 405535007401 heterodimer interface [polypeptide binding]; other site 405535007402 phosphorylation loop region [posttranslational modification] 405535007403 DinB superfamily; Region: DinB_2; pfam12867 405535007404 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 405535007405 short chain dehydrogenase; Provisional; Region: PRK06914 405535007406 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 405535007407 NADP binding site [chemical binding]; other site 405535007408 active site 405535007409 steroid binding site; other site 405535007410 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 405535007411 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 405535007412 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 405535007413 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 405535007414 nudix motif; other site 405535007415 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 405535007416 Protein phosphatase 2C; Region: PP2C_2; pfam13672 405535007417 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 405535007418 nucleotide binding site/active site [active] 405535007419 HIT family signature motif; other site 405535007420 catalytic residue [active] 405535007421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535007422 dimer interface [polypeptide binding]; other site 405535007423 conserved gate region; other site 405535007424 putative PBP binding loops; other site 405535007425 ABC-ATPase subunit interface; other site 405535007426 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 405535007427 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 405535007428 Walker A/P-loop; other site 405535007429 ATP binding site [chemical binding]; other site 405535007430 Q-loop/lid; other site 405535007431 ABC transporter signature motif; other site 405535007432 Walker B; other site 405535007433 D-loop; other site 405535007434 H-loop/switch region; other site 405535007435 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 405535007436 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 405535007437 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 405535007438 Clp protease; Region: CLP_protease; pfam00574 405535007439 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 405535007440 oligomer interface [polypeptide binding]; other site 405535007441 active site residues [active] 405535007442 RNA polymerase factor sigma-70; Validated; Region: PRK06704 405535007443 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535007444 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405535007445 DNA binding residues [nucleotide binding] 405535007446 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 405535007447 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 405535007448 catalytic loop [active] 405535007449 iron binding site [ion binding]; other site 405535007450 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 405535007451 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405535007452 active site 405535007453 dimer interface [polypeptide binding]; other site 405535007454 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405535007455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535007456 Coenzyme A binding pocket [chemical binding]; other site 405535007457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 405535007458 Chitin binding domain; Region: Chitin_bind_3; pfam03067 405535007459 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405535007460 Interdomain contacts; other site 405535007461 Cytokine receptor motif; other site 405535007462 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405535007463 Interdomain contacts; other site 405535007464 Cytokine receptor motif; other site 405535007465 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 405535007466 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 405535007467 glycosyltransferase, MGT family; Region: MGT; TIGR01426 405535007468 active site 405535007469 TDP-binding site; other site 405535007470 acceptor substrate-binding pocket; other site 405535007471 homodimer interface [polypeptide binding]; other site 405535007472 Uncharacterized conserved protein [Function unknown]; Region: COG1262 405535007473 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 405535007474 topology modulation protein; Reviewed; Region: PRK08118 405535007475 AAA domain; Region: AAA_17; pfam13207 405535007476 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 405535007477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535007478 S-adenosylmethionine binding site [chemical binding]; other site 405535007479 Protein of unknown function (DUF419); Region: DUF419; cl15265 405535007480 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 405535007481 Protein of unknown function; Region: DUF3658; pfam12395 405535007482 Protein of unknown function (DUF419); Region: DUF419; pfam04237 405535007483 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535007484 Coenzyme A binding pocket [chemical binding]; other site 405535007485 S-layer homology domain; Region: SLH; pfam00395 405535007486 S-layer homology domain; Region: SLH; pfam00395 405535007487 S-layer homology domain; Region: SLH; pfam00395 405535007488 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 405535007489 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405535007490 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 405535007491 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 405535007492 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 405535007493 active site 405535007494 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 405535007495 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535007496 Coenzyme A binding pocket [chemical binding]; other site 405535007497 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 405535007498 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 405535007499 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535007500 Coenzyme A binding pocket [chemical binding]; other site 405535007501 Predicted transcriptional regulators [Transcription]; Region: COG1695 405535007502 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405535007503 Protein of unknown function (DUF952); Region: DUF952; pfam06108 405535007504 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 405535007505 Part of AAA domain; Region: AAA_19; pfam13245 405535007506 Family description; Region: UvrD_C_2; pfam13538 405535007507 CAAX protease self-immunity; Region: Abi; pfam02517 405535007508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535007509 S-adenosylmethionine binding site [chemical binding]; other site 405535007510 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 405535007511 putative active site pocket [active] 405535007512 dimerization interface [polypeptide binding]; other site 405535007513 putative catalytic residue [active] 405535007514 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 405535007515 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405535007516 ATP binding site [chemical binding]; other site 405535007517 putative Mg++ binding site [ion binding]; other site 405535007518 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405535007519 nucleotide binding region [chemical binding]; other site 405535007520 ATP-binding site [chemical binding]; other site 405535007521 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 405535007522 HRDC domain; Region: HRDC; pfam00570 405535007523 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 405535007524 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 405535007525 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 405535007526 active site 405535007527 Zn binding site [ion binding]; other site 405535007528 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 405535007529 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 405535007530 DHHA2 domain; Region: DHHA2; pfam02833 405535007531 Chitin binding domain; Region: Chitin_bind_3; pfam03067 405535007532 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405535007533 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535007534 Coenzyme A binding pocket [chemical binding]; other site 405535007535 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 405535007536 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405535007537 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 405535007538 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 405535007539 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 405535007540 NAD(P) binding site [chemical binding]; other site 405535007541 catalytic residues [active] 405535007542 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 405535007543 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 405535007544 inhibitor site; inhibition site 405535007545 active site 405535007546 dimer interface [polypeptide binding]; other site 405535007547 catalytic residue [active] 405535007548 Proline racemase; Region: Pro_racemase; pfam05544 405535007549 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 405535007550 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 405535007551 Proline racemase; Region: Pro_racemase; pfam05544 405535007552 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 405535007553 hydroxyglutarate oxidase; Provisional; Region: PRK11728 405535007554 PAS domain; Region: PAS; smart00091 405535007555 PAS domain; Region: PAS_9; pfam13426 405535007556 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 405535007557 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535007558 Walker A motif; other site 405535007559 ATP binding site [chemical binding]; other site 405535007560 Walker B motif; other site 405535007561 arginine finger; other site 405535007562 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405535007563 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 405535007564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535007565 Walker A/P-loop; other site 405535007566 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 405535007567 catalytic loop [active] 405535007568 iron binding site [ion binding]; other site 405535007569 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 405535007570 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405535007571 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 405535007572 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 405535007573 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405535007574 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405535007575 DinB superfamily; Region: DinB_2; pfam12867 405535007576 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 405535007577 DltD N-terminal region; Region: DltD_N; pfam04915 405535007578 DltD central region; Region: DltD_M; pfam04918 405535007579 DltD C-terminal region; Region: DltD_C; pfam04914 405535007580 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405535007581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535007582 Coenzyme A binding pocket [chemical binding]; other site 405535007583 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405535007584 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405535007585 peptide binding site [polypeptide binding]; other site 405535007586 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405535007587 NlpC/P60 family; Region: NLPC_P60; pfam00877 405535007588 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 405535007589 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 405535007590 active site 405535007591 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 405535007592 Septum formation initiator; Region: DivIC; pfam04977 405535007593 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 405535007594 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 405535007595 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 405535007596 active site 405535007597 catalytic motif [active] 405535007598 Zn binding site [ion binding]; other site 405535007599 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405535007600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535007601 S-adenosylmethionine binding site [chemical binding]; other site 405535007602 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 405535007603 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 405535007604 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535007605 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535007606 dimerization interface [polypeptide binding]; other site 405535007607 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535007608 dimer interface [polypeptide binding]; other site 405535007609 phosphorylation site [posttranslational modification] 405535007610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535007611 ATP binding site [chemical binding]; other site 405535007612 Mg2+ binding site [ion binding]; other site 405535007613 G-X-G motif; other site 405535007614 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535007615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535007616 active site 405535007617 phosphorylation site [posttranslational modification] 405535007618 intermolecular recognition site; other site 405535007619 dimerization interface [polypeptide binding]; other site 405535007620 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535007621 DNA binding site [nucleotide binding] 405535007622 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 405535007623 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 405535007624 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535007625 motif II; other site 405535007626 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Provisional; Region: PRK14697 405535007627 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 405535007628 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 405535007629 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 405535007630 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 405535007631 Zn binding site [ion binding]; other site 405535007632 Short C-terminal domain; Region: SHOCT; pfam09851 405535007633 EDD domain protein, DegV family; Region: DegV; TIGR00762 405535007634 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 405535007635 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405535007636 Coenzyme A binding pocket [chemical binding]; other site 405535007637 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 405535007638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535007639 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405535007640 putative substrate translocation pore; other site 405535007641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535007642 putative substrate translocation pore; other site 405535007643 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 405535007644 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 405535007645 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 405535007646 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 405535007647 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 405535007648 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 405535007649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535007650 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405535007651 putative substrate translocation pore; other site 405535007652 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 405535007653 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 405535007654 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 405535007655 active site 405535007656 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 405535007657 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405535007658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535007659 S-adenosylmethionine binding site [chemical binding]; other site 405535007660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535007661 putative substrate translocation pore; other site 405535007662 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405535007663 aspartate aminotransferase; Provisional; Region: PRK07681 405535007664 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405535007665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535007666 homodimer interface [polypeptide binding]; other site 405535007667 catalytic residue [active] 405535007668 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 405535007669 pantothenate kinase; Provisional; Region: PRK13317 405535007670 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 405535007671 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 405535007672 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 405535007673 Protein of unknown function (DUF4052); Region: DUF4052; pfam13261 405535007674 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405535007675 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405535007676 Walker A/P-loop; other site 405535007677 ATP binding site [chemical binding]; other site 405535007678 Q-loop/lid; other site 405535007679 ABC transporter signature motif; other site 405535007680 Walker B; other site 405535007681 D-loop; other site 405535007682 H-loop/switch region; other site 405535007683 Predicted transcriptional regulators [Transcription]; Region: COG1725 405535007684 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535007685 DNA-binding site [nucleotide binding]; DNA binding site 405535007686 Protein of unknown function DUF99; Region: DUF99; cl00704 405535007687 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 405535007688 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 405535007689 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 405535007690 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 405535007691 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 405535007692 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 405535007693 Domain of unknown function DUF20; Region: UPF0118; pfam01594 405535007694 HNH endonuclease; Region: HNH_5; pfam14279 405535007695 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 405535007696 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 405535007697 active site 405535007698 dimer interface [polypeptide binding]; other site 405535007699 non-prolyl cis peptide bond; other site 405535007700 insertion regions; other site 405535007701 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 405535007702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 405535007703 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 405535007704 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405535007705 substrate binding pocket [chemical binding]; other site 405535007706 membrane-bound complex binding site; other site 405535007707 hinge residues; other site 405535007708 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 405535007709 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 405535007710 Walker A/P-loop; other site 405535007711 ATP binding site [chemical binding]; other site 405535007712 Q-loop/lid; other site 405535007713 ABC transporter signature motif; other site 405535007714 Walker B; other site 405535007715 D-loop; other site 405535007716 H-loop/switch region; other site 405535007717 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535007718 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535007719 Protein of unknown function (DUF402); Region: DUF402; pfam04167 405535007720 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 405535007721 nudix motif; other site 405535007722 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 405535007723 binding surface 405535007724 TPR motif; other site 405535007725 hypothetical protein; Provisional; Region: PRK09620 405535007726 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 405535007727 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 405535007728 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 405535007729 Coenzyme A binding pocket [chemical binding]; other site 405535007730 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 405535007731 DinB superfamily; Region: DinB_2; pfam12867 405535007732 Protein of unknown function (DUF664); Region: DUF664; pfam04978 405535007733 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 405535007734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535007735 Coenzyme A binding pocket [chemical binding]; other site 405535007736 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405535007737 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405535007738 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 405535007739 active site 405535007740 NTP binding site [chemical binding]; other site 405535007741 metal binding triad [ion binding]; metal-binding site 405535007742 antibiotic binding site [chemical binding]; other site 405535007743 A new structural DNA glycosylase; Region: AlkD_like; cd06561 405535007744 active site 405535007745 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 405535007746 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 405535007747 NodB motif; other site 405535007748 active site 405535007749 catalytic site [active] 405535007750 Zn binding site [ion binding]; other site 405535007751 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 405535007752 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 405535007753 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 405535007754 Sulfatase; Region: Sulfatase; pfam00884 405535007755 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 405535007756 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405535007757 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405535007758 ABC transporter; Region: ABC_tran_2; pfam12848 405535007759 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405535007760 hypothetical protein; Provisional; Region: PRK06761 405535007761 potential frameshift: common BLAST hit: gi|49477909|ref|YP_037015.1| MmpL family membrane protein 405535007762 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 405535007763 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 405535007764 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535007765 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535007766 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 405535007767 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535007768 Coenzyme A binding pocket [chemical binding]; other site 405535007769 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 405535007770 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 405535007771 hinge; other site 405535007772 active site 405535007773 prephenate dehydrogenase; Validated; Region: PRK06545 405535007774 prephenate dehydrogenase; Validated; Region: PRK08507 405535007775 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 405535007776 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 405535007777 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405535007778 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535007779 homodimer interface [polypeptide binding]; other site 405535007780 catalytic residue [active] 405535007781 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 405535007782 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 405535007783 Tetramer interface [polypeptide binding]; other site 405535007784 active site 405535007785 FMN-binding site [chemical binding]; other site 405535007786 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 405535007787 Chorismate mutase type II; Region: CM_2; cl00693 405535007788 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 405535007789 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 405535007790 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 405535007791 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 405535007792 Isochorismatase family; Region: Isochorismatase; pfam00857 405535007793 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 405535007794 catalytic triad [active] 405535007795 conserved cis-peptide bond; other site 405535007796 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405535007797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535007798 Coenzyme A binding pocket [chemical binding]; other site 405535007799 YfzA-like protein; Region: YfzA; pfam14118 405535007800 hypothetical protein; Provisional; Region: PRK06762 405535007801 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535007802 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535007803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 405535007804 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 405535007805 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535007806 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405535007807 DNA binding residues [nucleotide binding] 405535007808 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 405535007809 malate:quinone oxidoreductase; Validated; Region: PRK05257 405535007810 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 405535007811 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 405535007812 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 405535007813 ligand binding site [chemical binding]; other site 405535007814 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405535007815 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405535007816 TM-ABC transporter signature motif; other site 405535007817 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405535007818 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405535007819 TM-ABC transporter signature motif; other site 405535007820 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 405535007821 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 405535007822 Walker A/P-loop; other site 405535007823 ATP binding site [chemical binding]; other site 405535007824 Q-loop/lid; other site 405535007825 ABC transporter signature motif; other site 405535007826 Walker B; other site 405535007827 D-loop; other site 405535007828 H-loop/switch region; other site 405535007829 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405535007830 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 405535007831 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 405535007832 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 405535007833 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 405535007834 putative N- and C-terminal domain interface [polypeptide binding]; other site 405535007835 putative active site [active] 405535007836 putative MgATP binding site [chemical binding]; other site 405535007837 catalytic site [active] 405535007838 metal binding site [ion binding]; metal-binding site 405535007839 putative carbohydrate binding site [chemical binding]; other site 405535007840 Cupin domain; Region: Cupin_2; pfam07883 405535007841 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 405535007842 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 405535007843 putative active site; other site 405535007844 catalytic residue [active] 405535007845 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405535007846 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405535007847 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 405535007848 active site 405535007849 NTP binding site [chemical binding]; other site 405535007850 metal binding triad [ion binding]; metal-binding site 405535007851 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 405535007852 H+ Antiporter protein; Region: 2A0121; TIGR00900 405535007853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535007854 putative substrate translocation pore; other site 405535007855 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535007856 putative DNA binding site [nucleotide binding]; other site 405535007857 putative Zn2+ binding site [ion binding]; other site 405535007858 DinB superfamily; Region: DinB_2; pfam12867 405535007859 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405535007860 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405535007861 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405535007862 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 405535007863 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 405535007864 putative catalytic cysteine [active] 405535007865 gamma-glutamyl kinase; Provisional; Region: PRK05429 405535007866 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 405535007867 nucleotide binding site [chemical binding]; other site 405535007868 homotetrameric interface [polypeptide binding]; other site 405535007869 putative phosphate binding site [ion binding]; other site 405535007870 putative allosteric binding site; other site 405535007871 PUA domain; Region: PUA; pfam01472 405535007872 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 405535007873 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 405535007874 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 405535007875 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 405535007876 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 405535007877 putative metal binding site [ion binding]; other site 405535007878 putative dimer interface [polypeptide binding]; other site 405535007879 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 405535007880 Transcriptional regulator [Transcription]; Region: IclR; COG1414 405535007881 Bacterial transcriptional regulator; Region: IclR; pfam01614 405535007882 S-methylmethionine transporter; Provisional; Region: PRK11387 405535007883 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 405535007884 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 405535007885 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 405535007886 putative di-iron ligands [ion binding]; other site 405535007887 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 405535007888 dimer interface [polypeptide binding]; other site 405535007889 Alkaline phosphatase homologues; Region: alkPPc; smart00098 405535007890 active site 405535007891 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 405535007892 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535007893 salt bridge; other site 405535007894 non-specific DNA binding site [nucleotide binding]; other site 405535007895 sequence-specific DNA binding site [nucleotide binding]; other site 405535007896 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 405535007897 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 405535007898 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 405535007899 ATP binding site [chemical binding]; other site 405535007900 Mg2+ binding site [ion binding]; other site 405535007901 G-X-G motif; other site 405535007902 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 405535007903 LytTr DNA-binding domain; Region: LytTR; pfam04397 405535007904 uridine kinase; Provisional; Region: PRK07667 405535007905 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405535007906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535007907 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405535007908 Coenzyme A binding pocket [chemical binding]; other site 405535007909 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405535007910 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405535007911 active site 405535007912 metal binding site [ion binding]; metal-binding site 405535007913 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 405535007914 Predicted transcriptional regulators [Transcription]; Region: COG1695 405535007915 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405535007916 MoxR-like ATPases [General function prediction only]; Region: COG0714 405535007917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535007918 Walker A motif; other site 405535007919 ATP binding site [chemical binding]; other site 405535007920 Walker B motif; other site 405535007921 arginine finger; other site 405535007922 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 405535007923 Protein of unknown function DUF58; Region: DUF58; pfam01882 405535007924 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 405535007925 proline/glycine betaine transporter; Provisional; Region: PRK10642 405535007926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535007927 putative substrate translocation pore; other site 405535007928 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405535007929 active site 405535007930 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405535007931 active site 405535007932 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 405535007933 active site 405535007934 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 405535007935 Ligand binding site; other site 405535007936 Putative Catalytic site; other site 405535007937 DXD motif; other site 405535007938 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405535007939 active site 405535007940 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 405535007941 Ligand binding site; other site 405535007942 Putative Catalytic site; other site 405535007943 DXD motif; other site 405535007944 acetylornithine aminotransferase; Provisional; Region: PRK02627 405535007945 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405535007946 inhibitor-cofactor binding pocket; inhibition site 405535007947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535007948 catalytic residue [active] 405535007949 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 405535007950 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 405535007951 tetramer interface [polypeptide binding]; other site 405535007952 heme binding pocket [chemical binding]; other site 405535007953 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 405535007954 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 405535007955 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 405535007956 active site 405535007957 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 405535007958 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405535007959 Beta-lactamase; Region: Beta-lactamase; pfam00144 405535007960 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 405535007961 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 405535007962 Uncharacterized conserved protein [Function unknown]; Region: COG1359 405535007963 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 405535007964 dimer interface [polypeptide binding]; other site 405535007965 FMN binding site [chemical binding]; other site 405535007966 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405535007967 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535007968 putative DNA binding site [nucleotide binding]; other site 405535007969 putative Zn2+ binding site [ion binding]; other site 405535007970 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 405535007971 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 405535007972 G1 box; other site 405535007973 putative GEF interaction site [polypeptide binding]; other site 405535007974 GTP/Mg2+ binding site [chemical binding]; other site 405535007975 Switch I region; other site 405535007976 G2 box; other site 405535007977 G3 box; other site 405535007978 Switch II region; other site 405535007979 G4 box; other site 405535007980 G5 box; other site 405535007981 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 405535007982 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 405535007983 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 405535007984 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 405535007985 Cupin domain; Region: Cupin_2; pfam07883 405535007986 Cupin domain; Region: Cupin_2; pfam07883 405535007987 DinB superfamily; Region: DinB_2; pfam12867 405535007988 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 405535007989 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 405535007990 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 405535007991 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 405535007992 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 405535007993 active site 405535007994 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 405535007995 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405535007996 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 405535007997 acyl-activating enzyme (AAE) consensus motif; other site 405535007998 putative AMP binding site [chemical binding]; other site 405535007999 putative active site [active] 405535008000 putative CoA binding site [chemical binding]; other site 405535008001 putative acyltransferase; Provisional; Region: PRK05790 405535008002 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 405535008003 dimer interface [polypeptide binding]; other site 405535008004 active site 405535008005 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 405535008006 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405535008007 substrate binding site [chemical binding]; other site 405535008008 oxyanion hole (OAH) forming residues; other site 405535008009 trimer interface [polypeptide binding]; other site 405535008010 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 405535008011 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 405535008012 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 405535008013 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 405535008014 beta-galactosidase; Region: BGL; TIGR03356 405535008015 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 405535008016 active site 405535008017 methionine cluster; other site 405535008018 phosphorylation site [posttranslational modification] 405535008019 metal binding site [ion binding]; metal-binding site 405535008020 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 405535008021 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 405535008022 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405535008023 catalytic core [active] 405535008024 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 405535008025 Predicted peptidase [General function prediction only]; Region: COG4099 405535008026 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405535008027 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 405535008028 active site 405535008029 P-loop; other site 405535008030 phosphorylation site [posttranslational modification] 405535008031 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405535008032 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 405535008033 DNA binding residues [nucleotide binding] 405535008034 GAF domain; Region: GAF_2; pfam13185 405535008035 GAF domain; Region: GAF; cl17456 405535008036 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 405535008037 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 405535008038 benzoate transport; Region: 2A0115; TIGR00895 405535008039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535008040 putative substrate translocation pore; other site 405535008041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535008042 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 405535008043 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 405535008044 active site 405535008045 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 405535008046 nudix motif; other site 405535008047 YfzA-like protein; Region: YfzA; pfam14118 405535008048 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 405535008049 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405535008050 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405535008051 Walker A/P-loop; other site 405535008052 ATP binding site [chemical binding]; other site 405535008053 Q-loop/lid; other site 405535008054 ABC transporter signature motif; other site 405535008055 Walker B; other site 405535008056 D-loop; other site 405535008057 H-loop/switch region; other site 405535008058 Predicted transcriptional regulators [Transcription]; Region: COG1725 405535008059 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535008060 DNA-binding site [nucleotide binding]; DNA binding site 405535008061 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 405535008062 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 405535008063 putative NAD(P) binding site [chemical binding]; other site 405535008064 active site 405535008065 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405535008066 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405535008067 Walker A/P-loop; other site 405535008068 ATP binding site [chemical binding]; other site 405535008069 Q-loop/lid; other site 405535008070 ABC transporter signature motif; other site 405535008071 Walker B; other site 405535008072 D-loop; other site 405535008073 H-loop/switch region; other site 405535008074 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 405535008075 FtsX-like permease family; Region: FtsX; pfam02687 405535008076 FtsX-like permease family; Region: FtsX; pfam02687 405535008077 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405535008078 Beta-lactamase; Region: Beta-lactamase; pfam00144 405535008079 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405535008080 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405535008081 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 405535008082 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405535008083 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535008084 Coenzyme A binding pocket [chemical binding]; other site 405535008085 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 405535008086 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 405535008087 nudix motif; other site 405535008088 EamA-like transporter family; Region: EamA; pfam00892 405535008089 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405535008090 EamA-like transporter family; Region: EamA; pfam00892 405535008091 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405535008092 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535008093 DNA-binding site [nucleotide binding]; DNA binding site 405535008094 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405535008095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535008096 homodimer interface [polypeptide binding]; other site 405535008097 catalytic residue [active] 405535008098 hypothetical protein; Validated; Region: PRK00124 405535008099 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 405535008100 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 405535008101 uridine kinase; Validated; Region: PRK06696 405535008102 active site 405535008103 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 405535008104 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405535008105 active site 405535008106 metal binding site [ion binding]; metal-binding site 405535008107 Phosphotransferase enzyme family; Region: APH; pfam01636 405535008108 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405535008109 active site 405535008110 substrate binding site [chemical binding]; other site 405535008111 ATP binding site [chemical binding]; other site 405535008112 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 405535008113 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405535008114 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405535008115 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405535008116 Lysine riboswitch 405535008117 lysine transporter; Provisional; Region: PRK10836 405535008118 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 405535008119 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 405535008120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535008121 S-adenosylmethionine binding site [chemical binding]; other site 405535008122 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 405535008123 putative active site [active] 405535008124 nucleotide binding site [chemical binding]; other site 405535008125 nudix motif; other site 405535008126 putative metal binding site [ion binding]; other site 405535008127 Cephalosporin hydroxylase; Region: CmcI; pfam04989 405535008128 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405535008129 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405535008130 Catalytic site [active] 405535008131 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405535008132 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405535008133 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405535008134 NAD-dependent deacetylase; Provisional; Region: PRK00481 405535008135 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 405535008136 NAD+ binding site [chemical binding]; other site 405535008137 substrate binding site [chemical binding]; other site 405535008138 Zn binding site [ion binding]; other site 405535008139 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 405535008140 putative substrate binding pocket [chemical binding]; other site 405535008141 AC domain interface; other site 405535008142 catalytic triad [active] 405535008143 AB domain interface; other site 405535008144 interchain disulfide; other site 405535008145 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 405535008146 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405535008147 Predicted membrane protein [Function unknown]; Region: COG3817 405535008148 Protein of unknown function (DUF979); Region: DUF979; pfam06166 405535008149 Protein of unknown function (DUF969); Region: DUF969; pfam06149 405535008150 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 405535008151 putative active site [active] 405535008152 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 405535008153 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 405535008154 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 405535008155 Transcriptional regulator [Transcription]; Region: IclR; COG1414 405535008156 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 405535008157 Bacterial transcriptional regulator; Region: IclR; pfam01614 405535008158 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405535008159 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405535008160 Catalytic site [active] 405535008161 CutC family; Region: CutC; cl01218 405535008162 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 405535008163 stage II sporulation protein P; Region: spore_II_P; TIGR02867 405535008164 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535008165 dimerization interface [polypeptide binding]; other site 405535008166 putative DNA binding site [nucleotide binding]; other site 405535008167 putative Zn2+ binding site [ion binding]; other site 405535008168 DinB superfamily; Region: DinB_2; pfam12867 405535008169 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405535008170 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 405535008171 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 405535008172 Uncharacterized conserved protein [Function unknown]; Region: COG1434 405535008173 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 405535008174 putative active site [active] 405535008175 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405535008176 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405535008177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 405535008178 Nucleoside recognition; Region: Gate; pfam07670 405535008179 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 405535008180 Phosphotransferase enzyme family; Region: APH; pfam01636 405535008181 putative active site [active] 405535008182 putative substrate binding site [chemical binding]; other site 405535008183 ATP binding site [chemical binding]; other site 405535008184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535008185 Coenzyme A binding pocket [chemical binding]; other site 405535008186 Uncharacterized conserved protein [Function unknown]; Region: COG1633 405535008187 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 405535008188 dinuclear metal binding motif [ion binding]; other site 405535008189 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 405535008190 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 405535008191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535008192 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535008193 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 405535008194 phosphoenolpyruvate synthase; Validated; Region: PRK06241 405535008195 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 405535008196 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 405535008197 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405535008198 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 405535008199 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 405535008200 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 405535008201 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 405535008202 LysE type translocator; Region: LysE; pfam01810 405535008203 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 405535008204 Spore germination protein; Region: Spore_permease; cl17796 405535008205 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405535008206 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 405535008207 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 405535008208 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405535008209 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 405535008210 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 405535008211 NAD binding site [chemical binding]; other site 405535008212 catalytic Zn binding site [ion binding]; other site 405535008213 structural Zn binding site [ion binding]; other site 405535008214 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 405535008215 dimanganese center [ion binding]; other site 405535008216 aspartate ammonia-lyase; Provisional; Region: PRK14515 405535008217 Aspartase; Region: Aspartase; cd01357 405535008218 active sites [active] 405535008219 tetramer interface [polypeptide binding]; other site 405535008220 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 405535008221 active site 405535008222 homodimer interface [polypeptide binding]; other site 405535008223 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405535008224 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535008225 non-specific DNA binding site [nucleotide binding]; other site 405535008226 salt bridge; other site 405535008227 sequence-specific DNA binding site [nucleotide binding]; other site 405535008228 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 405535008229 Integrase core domain; Region: rve_3; cl15866 405535008230 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405535008231 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405535008232 Spore germination protein; Region: Spore_permease; pfam03845 405535008233 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405535008234 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 405535008235 PAS domain S-box; Region: sensory_box; TIGR00229 405535008236 PAS domain S-box; Region: sensory_box; TIGR00229 405535008237 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405535008238 putative active site [active] 405535008239 heme pocket [chemical binding]; other site 405535008240 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 405535008241 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405535008242 putative active site [active] 405535008243 heme pocket [chemical binding]; other site 405535008244 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535008245 dimer interface [polypeptide binding]; other site 405535008246 phosphorylation site [posttranslational modification] 405535008247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535008248 ATP binding site [chemical binding]; other site 405535008249 Mg2+ binding site [ion binding]; other site 405535008250 G-X-G motif; other site 405535008251 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405535008252 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405535008253 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405535008254 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405535008255 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 405535008256 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405535008257 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405535008258 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405535008259 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 405535008260 GIY-YIG motif/motif A; other site 405535008261 active site 405535008262 catalytic site [active] 405535008263 metal binding site [ion binding]; metal-binding site 405535008264 amino acid transporter; Region: 2A0306; TIGR00909 405535008265 Spore germination protein; Region: Spore_permease; cl17796 405535008266 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 405535008267 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405535008268 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 405535008269 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 405535008270 DoxX-like family; Region: DoxX_2; pfam13564 405535008271 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 405535008272 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405535008273 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405535008274 Spore germination protein; Region: Spore_permease; pfam03845 405535008275 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405535008276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535008277 Response regulator receiver domain; Region: Response_reg; pfam00072 405535008278 active site 405535008279 phosphorylation site [posttranslational modification] 405535008280 intermolecular recognition site; other site 405535008281 dimerization interface [polypeptide binding]; other site 405535008282 YcbB domain; Region: YcbB; pfam08664 405535008283 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535008284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535008285 ATP binding site [chemical binding]; other site 405535008286 Mg2+ binding site [ion binding]; other site 405535008287 G-X-G motif; other site 405535008288 glutaminase; Reviewed; Region: PRK12357 405535008289 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 405535008290 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405535008291 amino acid carrier protein; Region: agcS; TIGR00835 405535008292 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 405535008293 transmembrane helices; other site 405535008294 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 405535008295 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 405535008296 active site 405535008297 active site 405535008298 Erythromycin esterase; Region: Erythro_esteras; cl17110 405535008299 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 405535008300 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 405535008301 putative active site [active] 405535008302 putative metal binding site [ion binding]; other site 405535008303 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405535008304 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 405535008305 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 405535008306 tetramer interface [polypeptide binding]; other site 405535008307 heme binding pocket [chemical binding]; other site 405535008308 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405535008309 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405535008310 TAP-like protein; Region: Abhydrolase_4; pfam08386 405535008311 Isochorismatase family; Region: Isochorismatase; pfam00857 405535008312 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 405535008313 catalytic triad [active] 405535008314 dimer interface [polypeptide binding]; other site 405535008315 conserved cis-peptide bond; other site 405535008316 Isochorismatase family; Region: Isochorismatase; pfam00857 405535008317 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 405535008318 catalytic triad [active] 405535008319 dimer interface [polypeptide binding]; other site 405535008320 conserved cis-peptide bond; other site 405535008321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 405535008322 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 405535008323 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 405535008324 active site 405535008325 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405535008326 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405535008327 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405535008328 dimerization interface [polypeptide binding]; other site 405535008329 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 405535008330 Cl binding site [ion binding]; other site 405535008331 oligomer interface [polypeptide binding]; other site 405535008332 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 405535008333 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 405535008334 Mg binding site [ion binding]; other site 405535008335 nucleotide binding site [chemical binding]; other site 405535008336 putative protofilament interface [polypeptide binding]; other site 405535008337 Heat induced stress protein YflT; Region: YflT; pfam11181 405535008338 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405535008339 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 405535008340 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 405535008341 TspO/MBR family; Region: TspO_MBR; pfam03073 405535008342 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 405535008343 DNA photolyase; Region: DNA_photolyase; pfam00875 405535008344 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 405535008345 zinc binding site [ion binding]; other site 405535008346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 405535008347 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 405535008348 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 405535008349 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 405535008350 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 405535008351 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405535008352 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535008353 Coenzyme A binding pocket [chemical binding]; other site 405535008354 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 405535008355 UbiA prenyltransferase family; Region: UbiA; pfam01040 405535008356 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405535008357 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 405535008358 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 405535008359 B12 binding site [chemical binding]; other site 405535008360 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 405535008361 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 405535008362 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535008363 Walker A/P-loop; other site 405535008364 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405535008365 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 405535008366 DNA binding residues [nucleotide binding] 405535008367 dimerization interface [polypeptide binding]; other site 405535008368 Phosphotransferase enzyme family; Region: APH; pfam01636 405535008369 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405535008370 active site 405535008371 ATP binding site [chemical binding]; other site 405535008372 substrate binding site [chemical binding]; other site 405535008373 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 405535008374 active site 405535008375 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 405535008376 Low molecular weight phosphatase family; Region: LMWPc; cd00115 405535008377 active site 405535008378 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 405535008379 arsenical-resistance protein; Region: acr3; TIGR00832 405535008380 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405535008381 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 405535008382 putative metal binding site [ion binding]; other site 405535008383 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535008384 dimerization interface [polypeptide binding]; other site 405535008385 putative DNA binding site [nucleotide binding]; other site 405535008386 putative Zn2+ binding site [ion binding]; other site 405535008387 DinB superfamily; Region: DinB_2; pfam12867 405535008388 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 405535008389 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 405535008390 VanZ like family; Region: VanZ; pfam04892 405535008391 two-component sensor protein; Provisional; Region: cpxA; PRK09470 405535008392 HAMP domain; Region: HAMP; pfam00672 405535008393 dimerization interface [polypeptide binding]; other site 405535008394 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535008395 dimer interface [polypeptide binding]; other site 405535008396 phosphorylation site [posttranslational modification] 405535008397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535008398 ATP binding site [chemical binding]; other site 405535008399 Mg2+ binding site [ion binding]; other site 405535008400 G-X-G motif; other site 405535008401 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535008402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535008403 active site 405535008404 phosphorylation site [posttranslational modification] 405535008405 intermolecular recognition site; other site 405535008406 dimerization interface [polypeptide binding]; other site 405535008407 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535008408 DNA binding site [nucleotide binding] 405535008409 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535008410 Coenzyme A binding pocket [chemical binding]; other site 405535008411 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 405535008412 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 405535008413 putative NAD(P) binding site [chemical binding]; other site 405535008414 active site 405535008415 putative substrate binding site [chemical binding]; other site 405535008416 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405535008417 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535008418 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535008419 short chain dehydrogenase; Provisional; Region: PRK12746 405535008420 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 405535008421 NADP binding site [chemical binding]; other site 405535008422 homodimer interface [polypeptide binding]; other site 405535008423 active site 405535008424 substrate binding site [chemical binding]; other site 405535008425 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 405535008426 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535008427 putative DNA binding site [nucleotide binding]; other site 405535008428 putative Zn2+ binding site [ion binding]; other site 405535008429 AsnC family; Region: AsnC_trans_reg; pfam01037 405535008430 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 405535008431 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405535008432 metal binding site [ion binding]; metal-binding site 405535008433 AAA domain; Region: AAA_11; pfam13086 405535008434 Part of AAA domain; Region: AAA_19; pfam13245 405535008435 Erp protein C-terminus; Region: Erp_C; pfam06780 405535008436 AAA domain; Region: AAA_30; pfam13604 405535008437 AAA domain; Region: AAA_12; pfam13087 405535008438 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 405535008439 putative active site [active] 405535008440 catalytic site [active] 405535008441 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405535008442 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405535008443 active site 405535008444 metal binding site [ion binding]; metal-binding site 405535008445 HEAT repeats; Region: HEAT_2; pfam13646 405535008446 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 405535008447 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 405535008448 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 405535008449 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405535008450 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405535008451 putative transporter; Provisional; Region: PRK11021 405535008452 Beta-lactamase; Region: Beta-lactamase; pfam00144 405535008453 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405535008454 hypothetical protein; Provisional; Region: PRK06770 405535008455 putative monooxygenase; Provisional; Region: PRK11118 405535008456 DoxX-like family; Region: DoxX_2; pfam13564 405535008457 Transcriptional regulators [Transcription]; Region: MarR; COG1846 405535008458 MarR family; Region: MarR_2; pfam12802 405535008459 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 405535008460 Cytochrome P450; Region: p450; pfam00067 405535008461 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 405535008462 Flavodoxin; Region: Flavodoxin_1; pfam00258 405535008463 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 405535008464 FAD binding pocket [chemical binding]; other site 405535008465 FAD binding motif [chemical binding]; other site 405535008466 catalytic residues [active] 405535008467 NAD binding pocket [chemical binding]; other site 405535008468 phosphate binding motif [ion binding]; other site 405535008469 beta-alpha-beta structure motif; other site 405535008470 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 405535008471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535008472 putative substrate translocation pore; other site 405535008473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535008474 Malarial early transcribed membrane protein (ETRAMP); Region: ETRAMP; cl09917 405535008475 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 405535008476 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535008477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535008478 active site 405535008479 phosphorylation site [posttranslational modification] 405535008480 intermolecular recognition site; other site 405535008481 dimerization interface [polypeptide binding]; other site 405535008482 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535008483 DNA binding site [nucleotide binding] 405535008484 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535008485 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535008486 dimerization interface [polypeptide binding]; other site 405535008487 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535008488 dimer interface [polypeptide binding]; other site 405535008489 phosphorylation site [posttranslational modification] 405535008490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535008491 ATP binding site [chemical binding]; other site 405535008492 G-X-G motif; other site 405535008493 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 405535008494 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405535008495 D-cysteine desulfhydrase; Validated; Region: PRK03910 405535008496 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 405535008497 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405535008498 catalytic residue [active] 405535008499 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405535008500 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 405535008501 active site 405535008502 metal binding site [ion binding]; metal-binding site 405535008503 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 405535008504 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405535008505 Beta-lactamase; Region: Beta-lactamase; pfam00144 405535008506 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 405535008507 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 405535008508 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 405535008509 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405535008510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405535008511 NAD(P) binding site [chemical binding]; other site 405535008512 active site 405535008513 hypothetical protein; Provisional; Region: PRK06849 405535008514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405535008515 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 405535008516 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 405535008517 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 405535008518 dimer interface [polypeptide binding]; other site 405535008519 active site 405535008520 CoA binding pocket [chemical binding]; other site 405535008521 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 405535008522 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 405535008523 AAA domain; Region: AAA_33; pfam13671 405535008524 AAA domain; Region: AAA_17; pfam13207 405535008525 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 405535008526 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 405535008527 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405535008528 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405535008529 Walker A/P-loop; other site 405535008530 ATP binding site [chemical binding]; other site 405535008531 Q-loop/lid; other site 405535008532 ABC transporter signature motif; other site 405535008533 Walker B; other site 405535008534 D-loop; other site 405535008535 H-loop/switch region; other site 405535008536 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 405535008537 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405535008538 FtsX-like permease family; Region: FtsX; pfam02687 405535008539 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535008540 dimerization interface [polypeptide binding]; other site 405535008541 putative DNA binding site [nucleotide binding]; other site 405535008542 Predicted transcriptional regulator [Transcription]; Region: COG2345 405535008543 putative Zn2+ binding site [ion binding]; other site 405535008544 H+ Antiporter protein; Region: 2A0121; TIGR00900 405535008545 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 405535008546 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535008547 dimerization interface [polypeptide binding]; other site 405535008548 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535008549 dimer interface [polypeptide binding]; other site 405535008550 phosphorylation site [posttranslational modification] 405535008551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535008552 ATP binding site [chemical binding]; other site 405535008553 Mg2+ binding site [ion binding]; other site 405535008554 G-X-G motif; other site 405535008555 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535008556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535008557 active site 405535008558 phosphorylation site [posttranslational modification] 405535008559 intermolecular recognition site; other site 405535008560 dimerization interface [polypeptide binding]; other site 405535008561 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535008562 DNA binding site [nucleotide binding] 405535008563 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405535008564 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405535008565 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405535008566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535008567 D-galactonate transporter; Region: 2A0114; TIGR00893 405535008568 putative substrate translocation pore; other site 405535008569 Uncharacterized conserved protein [Function unknown]; Region: COG1556 405535008570 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 405535008571 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 405535008572 4Fe-4S binding domain; Region: Fer4; pfam00037 405535008573 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 405535008574 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 405535008575 Cysteine-rich domain; Region: CCG; pfam02754 405535008576 Cysteine-rich domain; Region: CCG; pfam02754 405535008577 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405535008578 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405535008579 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405535008580 dimerization interface [polypeptide binding]; other site 405535008581 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 405535008582 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 405535008583 putative dimer interface [polypeptide binding]; other site 405535008584 catalytic triad [active] 405535008585 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 405535008586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405535008587 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405535008588 active site 405535008589 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 405535008590 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 405535008591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535008592 putative substrate translocation pore; other site 405535008593 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 405535008594 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405535008595 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 405535008596 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535008597 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 405535008598 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 405535008599 inhibitor-cofactor binding pocket; inhibition site 405535008600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535008601 catalytic residue [active] 405535008602 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405535008603 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405535008604 DNA binding site [nucleotide binding] 405535008605 domain linker motif; other site 405535008606 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 405535008607 putative dimerization interface [polypeptide binding]; other site 405535008608 putative ligand binding site [chemical binding]; other site 405535008609 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535008610 TPR motif; other site 405535008611 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405535008612 binding surface 405535008613 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535008614 TPR motif; other site 405535008615 binding surface 405535008616 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257 405535008617 PKC phosphorylation site [posttranslational modification]; other site 405535008618 DNA polymerase IV; Reviewed; Region: PRK03103 405535008619 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 405535008620 active site 405535008621 DNA binding site [nucleotide binding] 405535008622 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 405535008623 YolD-like protein; Region: YolD; pfam08863 405535008624 Tar ligand binding domain homologue; Region: TarH; pfam02203 405535008625 Cache domain; Region: Cache_1; pfam02743 405535008626 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535008627 dimerization interface [polypeptide binding]; other site 405535008628 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405535008629 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405535008630 dimer interface [polypeptide binding]; other site 405535008631 putative CheW interface [polypeptide binding]; other site 405535008632 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405535008633 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405535008634 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 405535008635 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 405535008636 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 405535008637 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 405535008638 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 405535008639 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 405535008640 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 405535008641 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405535008642 inhibitor-cofactor binding pocket; inhibition site 405535008643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535008644 catalytic residue [active] 405535008645 Acylphosphatase; Region: Acylphosphatase; pfam00708 405535008646 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 405535008647 HypF finger; Region: zf-HYPF; pfam07503 405535008648 HypF finger; Region: zf-HYPF; pfam07503 405535008649 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 405535008650 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 405535008651 dimerization interface [polypeptide binding]; other site 405535008652 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 405535008653 ATP binding site [chemical binding]; other site 405535008654 Isochorismatase family; Region: Isochorismatase; pfam00857 405535008655 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 405535008656 catalytic triad [active] 405535008657 conserved cis-peptide bond; other site 405535008658 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 405535008659 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535008660 putative DNA binding site [nucleotide binding]; other site 405535008661 putative Zn2+ binding site [ion binding]; other site 405535008662 AsnC family; Region: AsnC_trans_reg; pfam01037 405535008663 putative transporter; Provisional; Region: PRK11021 405535008664 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 405535008665 Uncharacterized conserved protein [Function unknown]; Region: COG4198 405535008666 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 405535008667 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 405535008668 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 405535008669 putative ligand binding site [chemical binding]; other site 405535008670 putative NAD binding site [chemical binding]; other site 405535008671 putative catalytic site [active] 405535008672 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 405535008673 L-serine binding site [chemical binding]; other site 405535008674 ACT domain interface; other site 405535008675 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 405535008676 homodimer interface [polypeptide binding]; other site 405535008677 substrate-cofactor binding pocket; other site 405535008678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535008679 catalytic residue [active] 405535008680 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 405535008681 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 405535008682 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 405535008683 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535008684 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 405535008685 Uncharacterized conserved protein [Function unknown]; Region: COG2155 405535008686 Cupin domain; Region: Cupin_2; cl17218 405535008687 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 405535008688 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405535008689 Penicillin amidase; Region: Penicil_amidase; pfam01804 405535008690 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 405535008691 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 405535008692 active site 405535008693 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 405535008694 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 405535008695 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405535008696 amidase catalytic site [active] 405535008697 Zn binding residues [ion binding]; other site 405535008698 substrate binding site [chemical binding]; other site 405535008699 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535008700 S-layer homology domain; Region: SLH; pfam00395 405535008701 S-layer homology domain; Region: SLH; pfam00395 405535008702 S-layer homology domain; Region: SLH; pfam00395 405535008703 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 405535008704 A new structural DNA glycosylase; Region: AlkD_like; cd06561 405535008705 active site 405535008706 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 405535008707 S-layer homology domain; Region: SLH; pfam00395 405535008708 S-layer homology domain; Region: SLH; pfam00395 405535008709 S-layer homology domain; Region: SLH; pfam00395 405535008710 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 405535008711 putative metal binding site [ion binding]; other site 405535008712 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405535008713 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 405535008714 NETI protein; Region: NETI; pfam14044 405535008715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535008716 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405535008717 putative substrate translocation pore; other site 405535008718 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405535008719 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405535008720 TAP-like protein; Region: Abhydrolase_4; pfam08386 405535008721 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405535008722 MarR family; Region: MarR_2; pfam12802 405535008723 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405535008724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535008725 putative substrate translocation pore; other site 405535008726 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405535008727 Beta-lactamase; Region: Beta-lactamase; pfam00144 405535008728 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405535008729 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535008730 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535008731 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 405535008732 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 405535008733 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 405535008734 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405535008735 SWIM zinc finger; Region: SWIM; pfam04434 405535008736 YwiC-like protein; Region: YwiC; pfam14256 405535008737 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 405535008738 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405535008739 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405535008740 Walker A/P-loop; other site 405535008741 ATP binding site [chemical binding]; other site 405535008742 Q-loop/lid; other site 405535008743 ABC transporter signature motif; other site 405535008744 Walker B; other site 405535008745 D-loop; other site 405535008746 H-loop/switch region; other site 405535008747 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405535008748 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 405535008749 Walker A/P-loop; other site 405535008750 ATP binding site [chemical binding]; other site 405535008751 Q-loop/lid; other site 405535008752 ABC transporter signature motif; other site 405535008753 Walker B; other site 405535008754 D-loop; other site 405535008755 H-loop/switch region; other site 405535008756 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 405535008757 Calreticulin family; Region: Calreticulin; pfam00262 405535008758 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 405535008759 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 405535008760 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 405535008761 Predicted membrane protein [Function unknown]; Region: COG1288 405535008762 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 405535008763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535008764 putative substrate translocation pore; other site 405535008765 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 405535008766 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535008767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535008768 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405535008769 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405535008770 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 405535008771 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405535008772 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535008773 non-specific DNA binding site [nucleotide binding]; other site 405535008774 salt bridge; other site 405535008775 sequence-specific DNA binding site [nucleotide binding]; other site 405535008776 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 405535008777 nucleotide binding site/active site [active] 405535008778 HIT family signature motif; other site 405535008779 catalytic residue [active] 405535008780 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 405535008781 putative active site [active] 405535008782 nucleotide binding site [chemical binding]; other site 405535008783 nudix motif; other site 405535008784 putative metal binding site [ion binding]; other site 405535008785 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 405535008786 putative deacylase active site [active] 405535008787 histidyl-tRNA synthetase; Provisional; Region: PRK12420 405535008788 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 405535008789 dimer interface [polypeptide binding]; other site 405535008790 motif 1; other site 405535008791 active site 405535008792 motif 2; other site 405535008793 motif 3; other site 405535008794 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 405535008795 anticodon binding site; other site 405535008796 Predicted transcriptional regulators [Transcription]; Region: COG1733 405535008797 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 405535008798 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 405535008799 dimer interface [polypeptide binding]; other site 405535008800 FMN binding site [chemical binding]; other site 405535008801 pyruvate kinase; Validated; Region: PRK06739 405535008802 active site 405535008803 domain interfaces; other site 405535008804 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 405535008805 classical (c) SDRs; Region: SDR_c; cd05233 405535008806 NAD(P) binding site [chemical binding]; other site 405535008807 active site 405535008808 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 405535008809 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405535008810 Walker A/P-loop; other site 405535008811 ATP binding site [chemical binding]; other site 405535008812 Q-loop/lid; other site 405535008813 ABC transporter signature motif; other site 405535008814 Walker B; other site 405535008815 D-loop; other site 405535008816 H-loop/switch region; other site 405535008817 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 405535008818 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535008819 non-specific DNA binding site [nucleotide binding]; other site 405535008820 salt bridge; other site 405535008821 sequence-specific DNA binding site [nucleotide binding]; other site 405535008822 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 405535008823 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535008824 motif II; other site 405535008825 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 405535008826 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 405535008827 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 405535008828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405535008829 Coenzyme A binding pocket [chemical binding]; other site 405535008830 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 405535008831 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 405535008832 nudix motif; other site 405535008833 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 405535008834 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 405535008835 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405535008836 putative metal binding site [ion binding]; other site 405535008837 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 405535008838 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 405535008839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535008840 putative substrate translocation pore; other site 405535008841 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405535008842 maltose O-acetyltransferase; Provisional; Region: PRK10092 405535008843 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 405535008844 active site 405535008845 substrate binding site [chemical binding]; other site 405535008846 trimer interface [polypeptide binding]; other site 405535008847 CoA binding site [chemical binding]; other site 405535008848 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 405535008849 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 405535008850 active site 405535008851 HIGH motif; other site 405535008852 dimer interface [polypeptide binding]; other site 405535008853 KMSKS motif; other site 405535008854 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 405535008855 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 405535008856 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 405535008857 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 405535008858 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 405535008859 Domain of unknown function DUF20; Region: UPF0118; pfam01594 405535008860 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405535008861 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535008862 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405535008863 Coenzyme A binding pocket [chemical binding]; other site 405535008864 ydaO/yuaA leader 405535008865 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405535008866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535008867 S-adenosylmethionine binding site [chemical binding]; other site 405535008868 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 405535008869 CGNR zinc finger; Region: zf-CGNR; pfam11706 405535008870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535008871 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405535008872 putative substrate translocation pore; other site 405535008873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535008874 TPR motif; other site 405535008875 TPR repeat; Region: TPR_11; pfam13414 405535008876 binding surface 405535008877 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535008878 binding surface 405535008879 Tetratricopeptide repeat; Region: TPR_16; pfam13432 405535008880 TPR motif; other site 405535008881 hypothetical protein; Provisional; Region: PRK04164 405535008882 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405535008883 ATP synthase I chain; Region: ATP_synt_I; cl09170 405535008884 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 405535008885 Domain of unknown function DUF21; Region: DUF21; pfam01595 405535008886 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 405535008887 Transporter associated domain; Region: CorC_HlyC; smart01091 405535008888 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 405535008889 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405535008890 DNA binding residues [nucleotide binding] 405535008891 putative dimer interface [polypeptide binding]; other site 405535008892 EamA-like transporter family; Region: EamA; pfam00892 405535008893 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405535008894 EamA-like transporter family; Region: EamA; pfam00892 405535008895 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 405535008896 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 405535008897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 405535008898 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 405535008899 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 405535008900 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 405535008901 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 405535008902 N- and C-terminal domain interface [polypeptide binding]; other site 405535008903 active site 405535008904 catalytic site [active] 405535008905 metal binding site [ion binding]; metal-binding site 405535008906 carbohydrate binding site [chemical binding]; other site 405535008907 ATP binding site [chemical binding]; other site 405535008908 GntP family permease; Region: GntP_permease; pfam02447 405535008909 fructuronate transporter; Provisional; Region: PRK10034; cl15264 405535008910 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 405535008911 active site 405535008912 intersubunit interactions; other site 405535008913 catalytic residue [active] 405535008914 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 405535008915 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405535008916 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 405535008917 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 405535008918 TPP-binding site [chemical binding]; other site 405535008919 dimer interface [polypeptide binding]; other site 405535008920 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 405535008921 PYR/PP interface [polypeptide binding]; other site 405535008922 dimer interface [polypeptide binding]; other site 405535008923 TPP binding site [chemical binding]; other site 405535008924 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405535008925 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 405535008926 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 405535008927 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 405535008928 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 405535008929 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 405535008930 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405535008931 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 405535008932 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 405535008933 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 405535008934 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405535008935 putative NAD(P) binding site [chemical binding]; other site 405535008936 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 405535008937 classical (c) SDRs; Region: SDR_c; cd05233 405535008938 NAD(P) binding site [chemical binding]; other site 405535008939 active site 405535008940 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405535008941 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405535008942 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 405535008943 active site 405535008944 Zn binding site [ion binding]; other site 405535008945 Viral enhancin protein; Region: Enhancin; pfam03272 405535008946 Peptidase M60-like family; Region: M60-like; pfam13402 405535008947 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 405535008948 dimer interface [polypeptide binding]; other site 405535008949 FMN binding site [chemical binding]; other site 405535008950 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405535008951 active site 405535008952 hypothetical protein; Provisional; Region: PRK02487 405535008953 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 405535008954 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 405535008955 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 405535008956 IDEAL domain; Region: IDEAL; pfam08858 405535008957 Transcriptional regulator; Region: Rrf2; pfam02082 405535008958 Rrf2 family protein; Region: rrf2_super; TIGR00738 405535008959 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 405535008960 ArsC family; Region: ArsC; pfam03960 405535008961 putative catalytic residues [active] 405535008962 thiol/disulfide switch; other site 405535008963 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 405535008964 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 405535008965 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535008966 DNA-binding site [nucleotide binding]; DNA binding site 405535008967 UTRA domain; Region: UTRA; pfam07702 405535008968 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405535008969 putative oxidoreductase; Provisional; Region: PRK10206 405535008970 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 405535008971 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 405535008972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 405535008973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535008974 S-adenosylmethionine binding site [chemical binding]; other site 405535008975 Predicted transcriptional regulators [Transcription]; Region: COG1733 405535008976 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 405535008977 Predicted transcriptional regulators [Transcription]; Region: COG1733 405535008978 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535008979 dimerization interface [polypeptide binding]; other site 405535008980 putative DNA binding site [nucleotide binding]; other site 405535008981 putative Zn2+ binding site [ion binding]; other site 405535008982 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405535008983 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405535008984 active site 405535008985 catalytic tetrad [active] 405535008986 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 405535008987 putative hydrophobic ligand binding site [chemical binding]; other site 405535008988 protein interface [polypeptide binding]; other site 405535008989 gate; other site 405535008990 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405535008991 Phosphotransferase enzyme family; Region: APH; pfam01636 405535008992 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405535008993 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 405535008994 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 405535008995 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 405535008996 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535008997 Coenzyme A binding pocket [chemical binding]; other site 405535008998 C factor cell-cell signaling protein; Provisional; Region: PRK09009 405535008999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405535009000 NAD(P) binding site [chemical binding]; other site 405535009001 active site 405535009002 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405535009003 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405535009004 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 405535009005 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405535009006 acyl-activating enzyme (AAE) consensus motif; other site 405535009007 AMP binding site [chemical binding]; other site 405535009008 active site 405535009009 CoA binding site [chemical binding]; other site 405535009010 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 405535009011 Predicted transcriptional regulators [Transcription]; Region: COG1733 405535009012 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535009013 dimerization interface [polypeptide binding]; other site 405535009014 putative DNA binding site [nucleotide binding]; other site 405535009015 putative Zn2+ binding site [ion binding]; other site 405535009016 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535009017 dimerization interface [polypeptide binding]; other site 405535009018 putative DNA binding site [nucleotide binding]; other site 405535009019 putative Zn2+ binding site [ion binding]; other site 405535009020 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 405535009021 active site 405535009022 Glyco_18 domain; Region: Glyco_18; smart00636 405535009023 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 405535009024 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 405535009025 NodB motif; other site 405535009026 putative active site [active] 405535009027 putative catalytic site [active] 405535009028 putative Zn binding site [ion binding]; other site 405535009029 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 405535009030 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 405535009031 DXD motif; other site 405535009032 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 405535009033 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 405535009034 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535009035 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405535009036 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 405535009037 active site 405535009038 CAAX protease self-immunity; Region: Abi; pfam02517 405535009039 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535009040 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535009041 Protein of unknown function (DUF3963); Region: DUF3963; pfam13124 405535009042 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 405535009043 HTH domain; Region: HTH_11; pfam08279 405535009044 WYL domain; Region: WYL; pfam13280 405535009045 Protein of unknown function (DUF805); Region: DUF805; pfam05656 405535009046 ABC-2 type transporter; Region: ABC2_membrane; cl17235 405535009047 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 405535009048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535009049 Walker A/P-loop; other site 405535009050 ATP binding site [chemical binding]; other site 405535009051 Q-loop/lid; other site 405535009052 ABC transporter signature motif; other site 405535009053 Walker B; other site 405535009054 D-loop; other site 405535009055 H-loop/switch region; other site 405535009056 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 405535009057 Predicted transcriptional regulators [Transcription]; Region: COG1695 405535009058 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405535009059 hydroxylamine reductase; Provisional; Region: PRK12310 405535009060 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 405535009061 ACS interaction site; other site 405535009062 CODH interaction site; other site 405535009063 metal cluster binding site [ion binding]; other site 405535009064 Predicted membrane protein [Function unknown]; Region: COG1289 405535009065 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405535009066 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 405535009067 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 405535009068 metal binding site [ion binding]; metal-binding site 405535009069 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 405535009070 hypothetical protein; Provisional; Region: PRK06771 405535009071 Beta-lactamase; Region: Beta-lactamase; pfam00144 405535009072 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405535009073 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 405535009074 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 405535009075 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 405535009076 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405535009077 active site 405535009078 metal binding site [ion binding]; metal-binding site 405535009079 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 405535009080 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405535009081 ligand binding site [chemical binding]; other site 405535009082 flexible hinge region; other site 405535009083 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 405535009084 Protein of unknown function, DUF606; Region: DUF606; pfam04657 405535009085 Protein of unknown function, DUF606; Region: DUF606; pfam04657 405535009086 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405535009087 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 405535009088 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 405535009089 putative NAD(P) binding site [chemical binding]; other site 405535009090 dimer interface [polypeptide binding]; other site 405535009091 putative transport protein YifK; Provisional; Region: PRK10746 405535009092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535009093 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 405535009094 putative substrate translocation pore; other site 405535009095 Haemolysin XhlA; Region: XhlA; pfam10779 405535009096 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 405535009097 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 405535009098 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 405535009099 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 405535009100 transmembrane helices; other site 405535009101 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405535009102 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535009103 Coenzyme A binding pocket [chemical binding]; other site 405535009104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405535009105 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405535009106 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 405535009107 putative ligand binding residues [chemical binding]; other site 405535009108 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405535009109 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405535009110 ABC-ATPase subunit interface; other site 405535009111 dimer interface [polypeptide binding]; other site 405535009112 putative PBP binding regions; other site 405535009113 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405535009114 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405535009115 ABC-ATPase subunit interface; other site 405535009116 dimer interface [polypeptide binding]; other site 405535009117 putative PBP binding regions; other site 405535009118 Protein of unknown function (DUF817); Region: DUF817; pfam05675 405535009119 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 405535009120 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 405535009121 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 405535009122 DinB superfamily; Region: DinB_2; pfam12867 405535009123 DinB family; Region: DinB; cl17821 405535009124 CAAX protease self-immunity; Region: Abi; pfam02517 405535009125 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 405535009126 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 405535009127 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405535009128 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405535009129 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405535009130 dimerization interface [polypeptide binding]; other site 405535009131 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405535009132 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 405535009133 NADP binding site [chemical binding]; other site 405535009134 dimer interface [polypeptide binding]; other site 405535009135 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405535009136 catalytic core [active] 405535009137 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535009138 Coenzyme A binding pocket [chemical binding]; other site 405535009139 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 405535009140 MutS domain III; Region: MutS_III; pfam05192 405535009141 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535009142 Walker A/P-loop; other site 405535009143 ATP binding site [chemical binding]; other site 405535009144 Q-loop/lid; other site 405535009145 ABC transporter signature motif; other site 405535009146 Walker B; other site 405535009147 D-loop; other site 405535009148 H-loop/switch region; other site 405535009149 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 405535009150 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 405535009151 active site 405535009152 Na/Ca binding site [ion binding]; other site 405535009153 catalytic site [active] 405535009154 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 405535009155 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 405535009156 oligoendopeptidase F; Region: pepF; TIGR00181 405535009157 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 405535009158 active site 405535009159 Zn binding site [ion binding]; other site 405535009160 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405535009161 Beta-lactamase; Region: Beta-lactamase; pfam00144 405535009162 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535009163 putative substrate translocation pore; other site 405535009164 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405535009165 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405535009166 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405535009167 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 405535009168 putative dimerization interface [polypeptide binding]; other site 405535009169 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 405535009170 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 405535009171 putative active site [active] 405535009172 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 405535009173 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 405535009174 active site 405535009175 catalytic site [active] 405535009176 metal binding site [ion binding]; metal-binding site 405535009177 FAD binding domain; Region: FAD_binding_3; pfam01494 405535009178 hypothetical protein; Provisional; Region: PRK07236 405535009179 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535009180 dimerization interface [polypeptide binding]; other site 405535009181 putative DNA binding site [nucleotide binding]; other site 405535009182 putative Zn2+ binding site [ion binding]; other site 405535009183 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405535009184 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 405535009185 putative NAD(P) binding site [chemical binding]; other site 405535009186 Uncharacterized conserved protein [Function unknown]; Region: COG0397 405535009187 hypothetical protein; Validated; Region: PRK00029 405535009188 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535009189 TPR motif; other site 405535009190 binding surface 405535009191 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 405535009192 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 405535009193 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 405535009194 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 405535009195 Sodium Bile acid symporter family; Region: SBF; cl17470 405535009196 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 405535009197 FAD binding domain; Region: FAD_binding_4; pfam01565 405535009198 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 405535009199 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405535009200 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 405535009201 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 405535009202 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 405535009203 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 405535009204 trimer interface [polypeptide binding]; other site 405535009205 active site 405535009206 substrate binding site [chemical binding]; other site 405535009207 CoA binding site [chemical binding]; other site 405535009208 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 405535009209 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 405535009210 inhibitor-cofactor binding pocket; inhibition site 405535009211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535009212 catalytic residue [active] 405535009213 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 405535009214 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 405535009215 active site 405535009216 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405535009217 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405535009218 active site 405535009219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535009220 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405535009221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 405535009222 enoyl-CoA hydratase; Provisional; Region: PRK06688 405535009223 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405535009224 substrate binding site [chemical binding]; other site 405535009225 oxyanion hole (OAH) forming residues; other site 405535009226 trimer interface [polypeptide binding]; other site 405535009227 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 405535009228 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 405535009229 FOG: PKD repeat [General function prediction only]; Region: COG3291 405535009230 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 405535009231 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 405535009232 MgtC family; Region: MgtC; pfam02308 405535009233 Predicted acetyltransferase [General function prediction only]; Region: COG3981 405535009234 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405535009235 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 405535009236 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 405535009237 putative metal binding site [ion binding]; other site 405535009238 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405535009239 active site 405535009240 metal binding site [ion binding]; metal-binding site 405535009241 VanW like protein; Region: VanW; pfam04294 405535009242 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 405535009243 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 405535009244 exonuclease; Provisional; Region: PRK06722 405535009245 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 405535009246 active site 405535009247 catalytic site [active] 405535009248 substrate binding site [chemical binding]; other site 405535009249 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405535009250 DNA-binding site [nucleotide binding]; DNA binding site 405535009251 RNA-binding motif; other site 405535009252 flavodoxin; Provisional; Region: PRK06703 405535009253 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 405535009254 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 405535009255 nudix motif; other site 405535009256 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 405535009257 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009258 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009259 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009260 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009261 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009262 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009263 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009264 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009265 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009266 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009267 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009268 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009269 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009270 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009271 short chain dehydrogenase; Provisional; Region: PRK06924 405535009272 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 405535009273 NADP binding site [chemical binding]; other site 405535009274 homodimer interface [polypeptide binding]; other site 405535009275 active site 405535009276 Predicted acetyltransferase [General function prediction only]; Region: COG3393 405535009277 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405535009278 argininosuccinate lyase; Provisional; Region: PRK06705 405535009279 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 405535009280 active sites [active] 405535009281 tetramer interface [polypeptide binding]; other site 405535009282 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405535009283 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405535009284 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 405535009285 active site 405535009286 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 405535009287 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 405535009288 Na binding site [ion binding]; other site 405535009289 Protein of unknown function (DUF997); Region: DUF997; pfam06196 405535009290 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 405535009291 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 405535009292 NAD(P) binding site [chemical binding]; other site 405535009293 catalytic residues [active] 405535009294 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 405535009295 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 405535009296 NAD(P) binding site [chemical binding]; other site 405535009297 homotetramer interface [polypeptide binding]; other site 405535009298 homodimer interface [polypeptide binding]; other site 405535009299 active site 405535009300 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 405535009301 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 405535009302 Divergent PAP2 family; Region: DUF212; pfam02681 405535009303 Predicted permeases [General function prediction only]; Region: RarD; COG2962 405535009304 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 405535009305 antiporter inner membrane protein; Provisional; Region: PRK11670 405535009306 Domain of unknown function DUF59; Region: DUF59; pfam01883 405535009307 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 405535009308 Walker A motif; other site 405535009309 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 405535009310 MoaE interaction surface [polypeptide binding]; other site 405535009311 MoeB interaction surface [polypeptide binding]; other site 405535009312 thiocarboxylated glycine; other site 405535009313 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 405535009314 MoaE homodimer interface [polypeptide binding]; other site 405535009315 MoaD interaction [polypeptide binding]; other site 405535009316 active site residues [active] 405535009317 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 405535009318 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 405535009319 dimer interface [polypeptide binding]; other site 405535009320 putative functional site; other site 405535009321 putative MPT binding site; other site 405535009322 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 405535009323 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 405535009324 ATP binding site [chemical binding]; other site 405535009325 substrate interface [chemical binding]; other site 405535009326 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 405535009327 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 405535009328 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405535009329 FeS/SAM binding site; other site 405535009330 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 405535009331 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 405535009332 Uncharacterized conserved protein [Function unknown]; Region: COG5609 405535009333 Uncharacterized conserved protein [Function unknown]; Region: COG2427 405535009334 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 405535009335 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 405535009336 catalytic loop [active] 405535009337 iron binding site [ion binding]; other site 405535009338 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 405535009339 4Fe-4S binding domain; Region: Fer4; pfam00037 405535009340 4Fe-4S binding domain; Region: Fer4; pfam00037 405535009341 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 405535009342 [4Fe-4S] binding site [ion binding]; other site 405535009343 molybdopterin cofactor binding site; other site 405535009344 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 405535009345 molybdopterin cofactor binding site; other site 405535009346 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405535009347 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 405535009348 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405535009349 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405535009350 Tubulin like; Region: Tubulin_2; pfam13809 405535009351 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 405535009352 metal ion-dependent adhesion site (MIDAS); other site 405535009353 amidophosphoribosyltransferase; Provisional; Region: PRK09246 405535009354 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405535009355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535009356 S-adenosylmethionine binding site [chemical binding]; other site 405535009357 O-methyltransferase; Region: Methyltransf_2; pfam00891 405535009358 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405535009359 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405535009360 peptide binding site [polypeptide binding]; other site 405535009361 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405535009362 Helix-turn-helix domain; Region: HTH_28; pfam13518 405535009363 Helix-turn-helix domain; Region: HTH_28; pfam13518 405535009364 HTH-like domain; Region: HTH_21; pfam13276 405535009365 Integrase core domain; Region: rve; pfam00665 405535009366 Integrase core domain; Region: rve_2; pfam13333 405535009367 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405535009368 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405535009369 peptide binding site [polypeptide binding]; other site 405535009370 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405535009371 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405535009372 peptide binding site [polypeptide binding]; other site 405535009373 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 405535009374 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405535009375 Transcriptional regulator [Transcription]; Region: LytR; COG1316 405535009376 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 405535009377 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535009378 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405535009379 DNA binding residues [nucleotide binding] 405535009380 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405535009381 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405535009382 active site 405535009383 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 405535009384 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405535009385 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405535009386 Walker A/P-loop; other site 405535009387 ATP binding site [chemical binding]; other site 405535009388 Q-loop/lid; other site 405535009389 ABC transporter signature motif; other site 405535009390 Walker B; other site 405535009391 D-loop; other site 405535009392 H-loop/switch region; other site 405535009393 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535009394 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535009395 putative oxidoreductase; Provisional; Region: PRK11579 405535009396 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405535009397 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 405535009398 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 405535009399 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 405535009400 CAP-like domain; other site 405535009401 active site 405535009402 primary dimer interface [polypeptide binding]; other site 405535009403 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405535009404 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405535009405 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405535009406 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 405535009407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535009408 ATP binding site [chemical binding]; other site 405535009409 Mg2+ binding site [ion binding]; other site 405535009410 G-X-G motif; other site 405535009411 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 405535009412 anchoring element; other site 405535009413 dimer interface [polypeptide binding]; other site 405535009414 ATP binding site [chemical binding]; other site 405535009415 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 405535009416 active site 405535009417 putative metal-binding site [ion binding]; other site 405535009418 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 405535009419 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 405535009420 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 405535009421 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 405535009422 protein binding site [polypeptide binding]; other site 405535009423 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535009424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535009425 active site 405535009426 phosphorylation site [posttranslational modification] 405535009427 intermolecular recognition site; other site 405535009428 dimerization interface [polypeptide binding]; other site 405535009429 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535009430 DNA binding site [nucleotide binding] 405535009431 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 405535009432 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405535009433 FeS/SAM binding site; other site 405535009434 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 405535009435 Class III ribonucleotide reductase; Region: RNR_III; cd01675 405535009436 effector binding site; other site 405535009437 active site 405535009438 Zn binding site [ion binding]; other site 405535009439 glycine loop; other site 405535009440 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 405535009441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 405535009442 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 405535009443 active site 405535009444 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 405535009445 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405535009446 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405535009447 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 405535009448 active site 405535009449 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 405535009450 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 405535009451 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 405535009452 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 405535009453 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 405535009454 active site 405535009455 catalytic site [active] 405535009456 substrate binding site [chemical binding]; other site 405535009457 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 405535009458 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 405535009459 catalytic residues [active] 405535009460 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405535009461 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405535009462 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535009463 Walker A/P-loop; other site 405535009464 ATP binding site [chemical binding]; other site 405535009465 ABC transporter signature motif; other site 405535009466 Walker B; other site 405535009467 D-loop; other site 405535009468 H-loop/switch region; other site 405535009469 aconitate hydratase; Validated; Region: PRK09277 405535009470 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 405535009471 substrate binding site [chemical binding]; other site 405535009472 ligand binding site [chemical binding]; other site 405535009473 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 405535009474 substrate binding site [chemical binding]; other site 405535009475 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 405535009476 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405535009477 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 405535009478 NodB motif; other site 405535009479 active site 405535009480 catalytic site [active] 405535009481 metal binding site [ion binding]; metal-binding site 405535009482 Small acid-soluble spore protein P family; Region: SspP; cl12105 405535009483 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 405535009484 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 405535009485 putative dimer interface [polypeptide binding]; other site 405535009486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 405535009487 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 405535009488 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 405535009489 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405535009490 nudix motif; other site 405535009491 SAP domain; Region: SAP; pfam02037 405535009492 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 405535009493 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 405535009494 dimer interface [polypeptide binding]; other site 405535009495 active site 405535009496 acyl-CoA synthetase; Validated; Region: PRK07638 405535009497 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405535009498 acyl-activating enzyme (AAE) consensus motif; other site 405535009499 AMP binding site [chemical binding]; other site 405535009500 active site 405535009501 CoA binding site [chemical binding]; other site 405535009502 BioY family; Region: BioY; pfam02632 405535009503 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 405535009504 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 405535009505 dimer interface [polypeptide binding]; other site 405535009506 acyl-activating enzyme (AAE) consensus motif; other site 405535009507 putative active site [active] 405535009508 AMP binding site [chemical binding]; other site 405535009509 putative CoA binding site [chemical binding]; other site 405535009510 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535009511 Coenzyme A binding pocket [chemical binding]; other site 405535009512 S-layer homology domain; Region: SLH; pfam00395 405535009513 S-layer homology domain; Region: SLH; pfam00395 405535009514 S-layer homology domain; Region: SLH; pfam00395 405535009515 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 405535009516 active site 405535009517 catalytic motif [active] 405535009518 Zn binding site [ion binding]; other site 405535009519 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 405535009520 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405535009521 amidase catalytic site [active] 405535009522 Zn binding residues [ion binding]; other site 405535009523 substrate binding site [chemical binding]; other site 405535009524 active site 405535009525 Protein phosphatase 2C; Region: PP2C_2; pfam13672 405535009526 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405535009527 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405535009528 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405535009529 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 405535009530 dimer interface [polypeptide binding]; other site 405535009531 putative metal binding site [ion binding]; other site 405535009532 PAS domain S-box; Region: sensory_box; TIGR00229 405535009533 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405535009534 putative active site [active] 405535009535 heme pocket [chemical binding]; other site 405535009536 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 405535009537 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405535009538 putative active site [active] 405535009539 heme pocket [chemical binding]; other site 405535009540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535009541 dimer interface [polypeptide binding]; other site 405535009542 phosphorylation site [posttranslational modification] 405535009543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535009544 ATP binding site [chemical binding]; other site 405535009545 Mg2+ binding site [ion binding]; other site 405535009546 G-X-G motif; other site 405535009547 Predicted esterase [General function prediction only]; Region: COG0400 405535009548 putative hydrolase; Provisional; Region: PRK11460 405535009549 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 405535009550 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405535009551 Zn binding site [ion binding]; other site 405535009552 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 405535009553 Zn binding site [ion binding]; other site 405535009554 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 405535009555 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 405535009556 Na binding site [ion binding]; other site 405535009557 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 405535009558 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 405535009559 active site 405535009560 FMN binding site [chemical binding]; other site 405535009561 substrate binding site [chemical binding]; other site 405535009562 3Fe-4S cluster binding site [ion binding]; other site 405535009563 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 405535009564 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 405535009565 FMN binding site [chemical binding]; other site 405535009566 active site 405535009567 substrate binding site [chemical binding]; other site 405535009568 catalytic residue [active] 405535009569 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 405535009570 agmatinase; Region: agmatinase; TIGR01230 405535009571 Agmatinase-like family; Region: Agmatinase-like; cd09990 405535009572 active site 405535009573 oligomer interface [polypeptide binding]; other site 405535009574 Mn binding site [ion binding]; other site 405535009575 imidazolonepropionase; Validated; Region: PRK09356 405535009576 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 405535009577 active site 405535009578 urocanate hydratase; Provisional; Region: PRK05414 405535009579 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 405535009580 active sites [active] 405535009581 tetramer interface [polypeptide binding]; other site 405535009582 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 405535009583 hexamer interface [polypeptide binding]; other site 405535009584 RNA binding site [nucleotide binding]; other site 405535009585 Histidine-zinc binding site [chemical binding]; other site 405535009586 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 405535009587 conserved cys residue [active] 405535009588 AAA domain; Region: AAA_28; pfam13521 405535009589 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 405535009590 active site 405535009591 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 405535009592 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009593 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009594 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009595 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009596 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009597 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009598 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009599 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009600 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009601 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009602 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535009603 Group II catalytic intron 405535009604 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 405535009605 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 405535009606 putative active site [active] 405535009607 putative NTP binding site [chemical binding]; other site 405535009608 putative nucleic acid binding site [nucleotide binding]; other site 405535009609 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 405535009610 active site 405535009611 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 405535009612 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 405535009613 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 405535009614 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405535009615 EamA-like transporter family; Region: EamA; pfam00892 405535009616 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 405535009617 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405535009618 metal binding site [ion binding]; metal-binding site 405535009619 dimer interface [polypeptide binding]; other site 405535009620 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 405535009621 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405535009622 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405535009623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535009624 Walker A/P-loop; other site 405535009625 ATP binding site [chemical binding]; other site 405535009626 Q-loop/lid; other site 405535009627 ABC transporter signature motif; other site 405535009628 Walker B; other site 405535009629 D-loop; other site 405535009630 H-loop/switch region; other site 405535009631 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 405535009632 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405535009633 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 405535009634 putative dimerization interface [polypeptide binding]; other site 405535009635 putative substrate binding pocket [chemical binding]; other site 405535009636 holin-like protein; Validated; Region: PRK01658 405535009637 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 405535009638 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405535009639 nudix motif; other site 405535009640 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 405535009641 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405535009642 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405535009643 amidase catalytic site [active] 405535009644 Zn binding residues [ion binding]; other site 405535009645 substrate binding site [chemical binding]; other site 405535009646 S-layer homology domain; Region: SLH; pfam00395 405535009647 S-layer homology domain; Region: SLH; pfam00395 405535009648 S-layer homology domain; Region: SLH; pfam00395 405535009649 Nuclease-related domain; Region: NERD; pfam08378 405535009650 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405535009651 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405535009652 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 405535009653 Walker A/P-loop; other site 405535009654 ATP binding site [chemical binding]; other site 405535009655 Q-loop/lid; other site 405535009656 ABC transporter signature motif; other site 405535009657 Walker B; other site 405535009658 D-loop; other site 405535009659 H-loop/switch region; other site 405535009660 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405535009661 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 405535009662 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535009663 Walker A/P-loop; other site 405535009664 ATP binding site [chemical binding]; other site 405535009665 Q-loop/lid; other site 405535009666 ABC transporter signature motif; other site 405535009667 Walker B; other site 405535009668 D-loop; other site 405535009669 H-loop/switch region; other site 405535009670 hypothetical protein; Provisional; Region: PRK01844 405535009671 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 405535009672 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 405535009673 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 405535009674 TPP-binding site [chemical binding]; other site 405535009675 dimer interface [polypeptide binding]; other site 405535009676 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 405535009677 PYR/PP interface [polypeptide binding]; other site 405535009678 dimer interface [polypeptide binding]; other site 405535009679 TPP binding site [chemical binding]; other site 405535009680 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405535009681 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405535009682 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 405535009683 Probable transposase; Region: OrfB_IS605; pfam01385 405535009684 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 405535009685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535009686 dimer interface [polypeptide binding]; other site 405535009687 conserved gate region; other site 405535009688 ABC-ATPase subunit interface; other site 405535009689 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 405535009690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535009691 dimer interface [polypeptide binding]; other site 405535009692 conserved gate region; other site 405535009693 ABC-ATPase subunit interface; other site 405535009694 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 405535009695 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 405535009696 Walker A/P-loop; other site 405535009697 ATP binding site [chemical binding]; other site 405535009698 Q-loop/lid; other site 405535009699 ABC transporter signature motif; other site 405535009700 Walker B; other site 405535009701 D-loop; other site 405535009702 H-loop/switch region; other site 405535009703 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 405535009704 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405535009705 membrane-bound complex binding site; other site 405535009706 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 405535009707 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 405535009708 active site 405535009709 metal binding site [ion binding]; metal-binding site 405535009710 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405535009711 hypothetical protein; Provisional; Region: PRK01546 405535009712 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405535009713 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 405535009714 catalytic residues [active] 405535009715 catalytic nucleophile [active] 405535009716 LexA repressor; Validated; Region: PRK00215 405535009717 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535009718 putative DNA binding site [nucleotide binding]; other site 405535009719 putative Zn2+ binding site [ion binding]; other site 405535009720 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 405535009721 Catalytic site [active] 405535009722 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 405535009723 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 405535009724 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 405535009725 Predicted transcriptional regulators [Transcription]; Region: COG1695 405535009726 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405535009727 glutamine synthetase, type I; Region: GlnA; TIGR00653 405535009728 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 405535009729 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 405535009730 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 405535009731 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405535009732 DNA binding residues [nucleotide binding] 405535009733 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 405535009734 Aluminium resistance protein; Region: Alum_res; pfam06838 405535009735 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 405535009736 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 405535009737 HflX GTPase family; Region: HflX; cd01878 405535009738 G1 box; other site 405535009739 GTP/Mg2+ binding site [chemical binding]; other site 405535009740 Switch I region; other site 405535009741 G2 box; other site 405535009742 G3 box; other site 405535009743 Switch II region; other site 405535009744 G4 box; other site 405535009745 G5 box; other site 405535009746 Predicted membrane protein [Function unknown]; Region: COG2860 405535009747 UPF0126 domain; Region: UPF0126; pfam03458 405535009748 UPF0126 domain; Region: UPF0126; pfam03458 405535009749 stage V sporulation protein K; Region: spore_V_K; TIGR02881 405535009750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535009751 Walker A motif; other site 405535009752 ATP binding site [chemical binding]; other site 405535009753 Walker B motif; other site 405535009754 arginine finger; other site 405535009755 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 405535009756 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 405535009757 active site 405535009758 catalytic residues [active] 405535009759 DNA binding site [nucleotide binding] 405535009760 Int/Topo IB signature motif; other site 405535009761 bacterial Hfq-like; Region: Hfq; cd01716 405535009762 hexamer interface [polypeptide binding]; other site 405535009763 Sm1 motif; other site 405535009764 RNA binding site [nucleotide binding]; other site 405535009765 Sm2 motif; other site 405535009766 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 405535009767 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 405535009768 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535009769 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535009770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 405535009771 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 405535009772 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 405535009773 active site 405535009774 phosphorylation site [posttranslational modification] 405535009775 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 405535009776 active site 405535009777 P-loop; other site 405535009778 phosphorylation site [posttranslational modification] 405535009779 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 405535009780 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 405535009781 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 405535009782 putative substrate binding site [chemical binding]; other site 405535009783 putative ATP binding site [chemical binding]; other site 405535009784 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 405535009785 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 405535009786 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405535009787 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 405535009788 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 405535009789 dimer interface [polypeptide binding]; other site 405535009790 active site 405535009791 metal binding site [ion binding]; metal-binding site 405535009792 Predicted membrane protein [Function unknown]; Region: COG2322 405535009793 potential frameshift: common BLAST hit: gi|52141766|ref|YP_085064.1| gamma-aminobutyrate permease 405535009794 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 405535009795 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 405535009796 potential frameshift: common BLAST hit: gi|49478343|ref|YP_037789.1| chitinase 405535009797 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 405535009798 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 405535009799 active site 405535009800 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 405535009801 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 405535009802 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 405535009803 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405535009804 putative active site [active] 405535009805 putative metal binding site [ion binding]; other site 405535009806 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 405535009807 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 405535009808 IHF dimer interface [polypeptide binding]; other site 405535009809 IHF - DNA interface [nucleotide binding]; other site 405535009810 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 405535009811 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405535009812 metal-binding site [ion binding] 405535009813 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 405535009814 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405535009815 metal-binding site [ion binding] 405535009816 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405535009817 Soluble P-type ATPase [General function prediction only]; Region: COG4087 405535009818 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 405535009819 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405535009820 metal-binding site [ion binding] 405535009821 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 405535009822 putative homodimer interface [polypeptide binding]; other site 405535009823 putative homotetramer interface [polypeptide binding]; other site 405535009824 putative allosteric switch controlling residues; other site 405535009825 putative metal binding site [ion binding]; other site 405535009826 putative homodimer-homodimer interface [polypeptide binding]; other site 405535009827 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 405535009828 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405535009829 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405535009830 Walker A/P-loop; other site 405535009831 ATP binding site [chemical binding]; other site 405535009832 Q-loop/lid; other site 405535009833 ABC transporter signature motif; other site 405535009834 Walker B; other site 405535009835 D-loop; other site 405535009836 H-loop/switch region; other site 405535009837 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405535009838 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405535009839 ABC-ATPase subunit interface; other site 405535009840 dimer interface [polypeptide binding]; other site 405535009841 putative PBP binding regions; other site 405535009842 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405535009843 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405535009844 ABC-ATPase subunit interface; other site 405535009845 dimer interface [polypeptide binding]; other site 405535009846 putative PBP binding regions; other site 405535009847 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405535009848 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 405535009849 putative ligand binding residues [chemical binding]; other site 405535009850 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 405535009851 active site 405535009852 putative catalytic site [active] 405535009853 DNA binding site [nucleotide binding] 405535009854 putative phosphate binding site [ion binding]; other site 405535009855 metal binding site A [ion binding]; metal-binding site 405535009856 AP binding site [nucleotide binding]; other site 405535009857 metal binding site B [ion binding]; metal-binding site 405535009858 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 405535009859 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 405535009860 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405535009861 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405535009862 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 405535009863 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 405535009864 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 405535009865 DNA binding site [nucleotide binding] 405535009866 active site 405535009867 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 405535009868 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 405535009869 endonuclease III; Region: ENDO3c; smart00478 405535009870 minor groove reading motif; other site 405535009871 helix-hairpin-helix signature motif; other site 405535009872 substrate binding pocket [chemical binding]; other site 405535009873 active site 405535009874 peptidase T; Region: peptidase-T; TIGR01882 405535009875 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 405535009876 metal binding site [ion binding]; metal-binding site 405535009877 dimer interface [polypeptide binding]; other site 405535009878 Predicted membrane protein [Function unknown]; Region: COG2364 405535009879 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405535009880 hypothetical protein; Provisional; Region: PRK06764 405535009881 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405535009882 catalytic core [active] 405535009883 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405535009884 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405535009885 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405535009886 active site 405535009887 PAS domain S-box; Region: sensory_box; TIGR00229 405535009888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405535009889 putative active site [active] 405535009890 heme pocket [chemical binding]; other site 405535009891 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405535009892 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405535009893 metal binding site [ion binding]; metal-binding site 405535009894 active site 405535009895 I-site; other site 405535009896 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405535009897 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 405535009898 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 405535009899 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 405535009900 holin-like protein; Validated; Region: PRK01658 405535009901 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405535009902 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535009903 DNA-binding site [nucleotide binding]; DNA binding site 405535009904 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405535009905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535009906 homodimer interface [polypeptide binding]; other site 405535009907 catalytic residue [active] 405535009908 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405535009909 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 405535009910 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 405535009911 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 405535009912 active site 405535009913 catalytic site [active] 405535009914 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 405535009915 putative active site [active] 405535009916 putative catalytic triad [active] 405535009917 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 405535009918 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405535009919 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 405535009920 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405535009921 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 405535009922 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 405535009923 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405535009924 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 405535009925 Sulfatase; Region: Sulfatase; pfam00884 405535009926 Tetratricopeptide repeat; Region: TPR_16; pfam13432 405535009927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535009928 binding surface 405535009929 TPR motif; other site 405535009930 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 405535009931 G1 box; other site 405535009932 GTP/Mg2+ binding site [chemical binding]; other site 405535009933 Switch I region; other site 405535009934 G3 box; other site 405535009935 Switch II region; other site 405535009936 G4 box; other site 405535009937 G5 box; other site 405535009938 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 405535009939 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 405535009940 active site 405535009941 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 405535009942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535009943 ATP binding site [chemical binding]; other site 405535009944 Mg2+ binding site [ion binding]; other site 405535009945 G-X-G motif; other site 405535009946 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 405535009947 ATP binding site [chemical binding]; other site 405535009948 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 405535009949 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 405535009950 MutS domain I; Region: MutS_I; pfam01624 405535009951 MutS domain II; Region: MutS_II; pfam05188 405535009952 MutS domain III; Region: MutS_III; pfam05192 405535009953 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 405535009954 Walker A/P-loop; other site 405535009955 ATP binding site [chemical binding]; other site 405535009956 Q-loop/lid; other site 405535009957 ABC transporter signature motif; other site 405535009958 Walker B; other site 405535009959 D-loop; other site 405535009960 H-loop/switch region; other site 405535009961 Outer spore coat protein E (CotE); Region: CotE; pfam10628 405535009962 Predicted membrane protein [Function unknown]; Region: COG4550 405535009963 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 405535009964 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 405535009965 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405535009966 FeS/SAM binding site; other site 405535009967 TRAM domain; Region: TRAM; pfam01938 405535009968 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 405535009969 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 405535009970 TPP-binding site [chemical binding]; other site 405535009971 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 405535009972 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 405535009973 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 405535009974 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 405535009975 dimer interface [polypeptide binding]; other site 405535009976 PYR/PP interface [polypeptide binding]; other site 405535009977 TPP binding site [chemical binding]; other site 405535009978 substrate binding site [chemical binding]; other site 405535009979 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405535009980 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 405535009981 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 405535009982 active site 405535009983 dimer interface [polypeptide binding]; other site 405535009984 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 405535009985 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 405535009986 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405535009987 putative active site [active] 405535009988 metal binding site [ion binding]; metal-binding site 405535009989 homodimer binding site [polypeptide binding]; other site 405535009990 phosphodiesterase; Provisional; Region: PRK12704 405535009991 Uncharacterized conserved protein [Function unknown]; Region: COG3334 405535009992 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405535009993 Zn2+ binding site [ion binding]; other site 405535009994 Mg2+ binding site [ion binding]; other site 405535009995 recA bacterial DNA recombination protein; Region: RecA; cl17211 405535009996 recA bacterial DNA recombination protein; Region: RecA; cl17211 405535009997 competence damage-inducible protein A; Provisional; Region: PRK00549 405535009998 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 405535009999 putative MPT binding site; other site 405535010000 Competence-damaged protein; Region: CinA; pfam02464 405535010001 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 405535010002 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 405535010003 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535010004 non-specific DNA binding site [nucleotide binding]; other site 405535010005 salt bridge; other site 405535010006 sequence-specific DNA binding site [nucleotide binding]; other site 405535010007 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 405535010008 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 405535010009 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 405535010010 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 405535010011 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 405535010012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405535010013 NAD(P) binding site [chemical binding]; other site 405535010014 active site 405535010015 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 405535010016 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 405535010017 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 405535010018 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 405535010019 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 405535010020 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405535010021 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 405535010022 TM-ABC transporter signature motif; other site 405535010023 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405535010024 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 405535010025 TM-ABC transporter signature motif; other site 405535010026 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 405535010027 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 405535010028 Walker A/P-loop; other site 405535010029 ATP binding site [chemical binding]; other site 405535010030 Q-loop/lid; other site 405535010031 ABC transporter signature motif; other site 405535010032 Walker B; other site 405535010033 D-loop; other site 405535010034 H-loop/switch region; other site 405535010035 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405535010036 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 405535010037 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 405535010038 ligand binding site [chemical binding]; other site 405535010039 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 405535010040 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535010041 DNA-binding site [nucleotide binding]; DNA binding site 405535010042 UTRA domain; Region: UTRA; pfam07702 405535010043 Tetraspanin family; Region: Tetraspannin; pfam00335 405535010044 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 405535010045 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 405535010046 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 405535010047 YlzJ-like protein; Region: YlzJ; pfam14035 405535010048 Clp protease; Region: CLP_protease; pfam00574 405535010049 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 405535010050 active site 405535010051 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 405535010052 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405535010053 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 405535010054 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 405535010055 dihydrodipicolinate synthase; Region: dapA; TIGR00674 405535010056 dimer interface [polypeptide binding]; other site 405535010057 active site 405535010058 catalytic residue [active] 405535010059 aspartate kinase I; Reviewed; Region: PRK08210 405535010060 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 405535010061 nucleotide binding site [chemical binding]; other site 405535010062 substrate binding site [chemical binding]; other site 405535010063 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 405535010064 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 405535010065 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 405535010066 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 405535010067 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 405535010068 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 405535010069 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 405535010070 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 405535010071 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 405535010072 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 405535010073 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 405535010074 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 405535010075 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 405535010076 NodB motif; other site 405535010077 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 405535010078 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 405535010079 RNase E interface [polypeptide binding]; other site 405535010080 trimer interface [polypeptide binding]; other site 405535010081 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 405535010082 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 405535010083 RNase E interface [polypeptide binding]; other site 405535010084 trimer interface [polypeptide binding]; other site 405535010085 active site 405535010086 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 405535010087 putative nucleic acid binding region [nucleotide binding]; other site 405535010088 G-X-X-G motif; other site 405535010089 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 405535010090 RNA binding site [nucleotide binding]; other site 405535010091 domain interface; other site 405535010092 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 405535010093 16S/18S rRNA binding site [nucleotide binding]; other site 405535010094 S13e-L30e interaction site [polypeptide binding]; other site 405535010095 25S rRNA binding site [nucleotide binding]; other site 405535010096 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 405535010097 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 405535010098 active site 405535010099 Riboflavin kinase; Region: Flavokinase; smart00904 405535010100 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 405535010101 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 405535010102 RNA binding site [nucleotide binding]; other site 405535010103 active site 405535010104 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 405535010105 Protein of unknown function (DUF503); Region: DUF503; pfam04456 405535010106 potential frameshift: common BLAST hit: gi|52141676|ref|YP_085154.1| translation initiation factor IF-2 405535010107 Translation-initiation factor 2; Region: IF-2; pfam11987 405535010108 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 405535010109 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 405535010110 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 405535010111 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 405535010112 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 405535010113 G1 box; other site 405535010114 putative GEF interaction site [polypeptide binding]; other site 405535010115 GTP/Mg2+ binding site [chemical binding]; other site 405535010116 Switch I region; other site 405535010117 G2 box; other site 405535010118 G3 box; other site 405535010119 Switch II region; other site 405535010120 G4 box; other site 405535010121 G5 box; other site 405535010122 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 405535010123 hypothetical protein; Provisional; Region: PRK07714 405535010124 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 405535010125 putative RNA binding cleft [nucleotide binding]; other site 405535010126 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 405535010127 NusA N-terminal domain; Region: NusA_N; pfam08529 405535010128 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 405535010129 RNA binding site [nucleotide binding]; other site 405535010130 homodimer interface [polypeptide binding]; other site 405535010131 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 405535010132 G-X-X-G motif; other site 405535010133 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 405535010134 G-X-X-G motif; other site 405535010135 ribosome maturation protein RimP; Reviewed; Region: PRK00092 405535010136 Sm and related proteins; Region: Sm_like; cl00259 405535010137 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 405535010138 putative oligomer interface [polypeptide binding]; other site 405535010139 putative RNA binding site [nucleotide binding]; other site 405535010140 DNA polymerase III PolC; Validated; Region: polC; PRK00448 405535010141 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 405535010142 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 405535010143 generic binding surface II; other site 405535010144 generic binding surface I; other site 405535010145 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 405535010146 active site 405535010147 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 405535010148 active site 405535010149 catalytic site [active] 405535010150 substrate binding site [chemical binding]; other site 405535010151 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 405535010152 prolyl-tRNA synthetase; Provisional; Region: PRK09194 405535010153 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 405535010154 dimer interface [polypeptide binding]; other site 405535010155 motif 1; other site 405535010156 active site 405535010157 motif 2; other site 405535010158 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 405535010159 putative deacylase active site [active] 405535010160 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 405535010161 active site 405535010162 motif 3; other site 405535010163 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 405535010164 anticodon binding site; other site 405535010165 RIP metalloprotease RseP; Region: TIGR00054 405535010166 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 405535010167 active site 405535010168 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 405535010169 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 405535010170 protein binding site [polypeptide binding]; other site 405535010171 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 405535010172 putative substrate binding region [chemical binding]; other site 405535010173 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 405535010174 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 405535010175 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 405535010176 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 405535010177 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 405535010178 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 405535010179 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 405535010180 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 405535010181 catalytic residue [active] 405535010182 putative FPP diphosphate binding site; other site 405535010183 putative FPP binding hydrophobic cleft; other site 405535010184 dimer interface [polypeptide binding]; other site 405535010185 putative IPP diphosphate binding site; other site 405535010186 ribosome recycling factor; Reviewed; Region: frr; PRK00083 405535010187 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 405535010188 hinge region; other site 405535010189 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 405535010190 putative nucleotide binding site [chemical binding]; other site 405535010191 uridine monophosphate binding site [chemical binding]; other site 405535010192 homohexameric interface [polypeptide binding]; other site 405535010193 elongation factor Ts; Provisional; Region: tsf; PRK09377 405535010194 UBA/TS-N domain; Region: UBA; pfam00627 405535010195 Elongation factor TS; Region: EF_TS; pfam00889 405535010196 Elongation factor TS; Region: EF_TS; pfam00889 405535010197 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 405535010198 rRNA interaction site [nucleotide binding]; other site 405535010199 S8 interaction site; other site 405535010200 putative laminin-1 binding site; other site 405535010201 transcriptional repressor CodY; Validated; Region: PRK04158 405535010202 CodY GAF-like domain; Region: CodY; pfam06018 405535010203 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 405535010204 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 405535010205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535010206 Walker A motif; other site 405535010207 ATP binding site [chemical binding]; other site 405535010208 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 405535010209 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 405535010210 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 405535010211 active site 405535010212 HslU subunit interaction site [polypeptide binding]; other site 405535010213 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 405535010214 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 405535010215 active site 405535010216 Int/Topo IB signature motif; other site 405535010217 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 405535010218 Glucose inhibited division protein A; Region: GIDA; pfam01134 405535010219 DNA topoisomerase I; Validated; Region: PRK05582 405535010220 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 405535010221 active site 405535010222 interdomain interaction site; other site 405535010223 putative metal-binding site [ion binding]; other site 405535010224 nucleotide binding site [chemical binding]; other site 405535010225 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 405535010226 domain I; other site 405535010227 DNA binding groove [nucleotide binding] 405535010228 phosphate binding site [ion binding]; other site 405535010229 domain II; other site 405535010230 domain III; other site 405535010231 nucleotide binding site [chemical binding]; other site 405535010232 catalytic site [active] 405535010233 domain IV; other site 405535010234 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 405535010235 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 405535010236 DNA protecting protein DprA; Region: dprA; TIGR00732 405535010237 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 405535010238 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 405535010239 CoA binding domain; Region: CoA_binding; smart00881 405535010240 CoA-ligase; Region: Ligase_CoA; pfam00549 405535010241 potential frameshift: common BLAST hit: gi|217961256|ref|YP_002339824.1| succinate-CoA ligase (ADP-forming), beta subunit 405535010242 CoA-ligase; Region: Ligase_CoA; pfam00549 405535010243 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 405535010244 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 405535010245 RNA/DNA hybrid binding site [nucleotide binding]; other site 405535010246 active site 405535010247 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 405535010248 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 405535010249 GTP/Mg2+ binding site [chemical binding]; other site 405535010250 G4 box; other site 405535010251 G5 box; other site 405535010252 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 405535010253 G1 box; other site 405535010254 G1 box; other site 405535010255 GTP/Mg2+ binding site [chemical binding]; other site 405535010256 Switch I region; other site 405535010257 G2 box; other site 405535010258 G2 box; other site 405535010259 G3 box; other site 405535010260 G3 box; other site 405535010261 Switch II region; other site 405535010262 Switch II region; other site 405535010263 G4 box; other site 405535010264 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405535010265 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405535010266 Catalytic site [active] 405535010267 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405535010268 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 405535010269 Ribosomal protein L19 leader 405535010270 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 405535010271 potential frameshift: common BLAST hit: gi|217961262|ref|YP_002339830.1| 16S rRNA processing protein RimM 405535010272 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 405535010273 PRC-barrel domain; Region: PRC; pfam05239 405535010274 RimM N-terminal domain; Region: RimM; pfam01782 405535010275 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 405535010276 KH domain; Region: KH_4; pfam13083 405535010277 G-X-X-G motif; other site 405535010278 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 405535010279 signal recognition particle protein; Provisional; Region: PRK10867 405535010280 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 405535010281 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 405535010282 P loop; other site 405535010283 GTP binding site [chemical binding]; other site 405535010284 Signal peptide binding domain; Region: SRP_SPB; pfam02978 405535010285 putative DNA-binding protein; Validated; Region: PRK00118 405535010286 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 405535010287 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 405535010288 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 405535010289 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 405535010290 P loop; other site 405535010291 GTP binding site [chemical binding]; other site 405535010292 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 405535010293 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 405535010294 Walker A/P-loop; other site 405535010295 ATP binding site [chemical binding]; other site 405535010296 Q-loop/lid; other site 405535010297 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 405535010298 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 405535010299 ABC transporter signature motif; other site 405535010300 Walker B; other site 405535010301 D-loop; other site 405535010302 H-loop/switch region; other site 405535010303 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 405535010304 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 405535010305 dimerization interface [polypeptide binding]; other site 405535010306 active site 405535010307 metal binding site [ion binding]; metal-binding site 405535010308 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 405535010309 dsRNA binding site [nucleotide binding]; other site 405535010310 acyl carrier protein; Provisional; Region: acpP; PRK00982 405535010311 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 405535010312 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 405535010313 NAD(P) binding site [chemical binding]; other site 405535010314 homotetramer interface [polypeptide binding]; other site 405535010315 homodimer interface [polypeptide binding]; other site 405535010316 active site 405535010317 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 405535010318 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 405535010319 putative phosphate acyltransferase; Provisional; Region: PRK05331 405535010320 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 405535010321 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 405535010322 active site 2 [active] 405535010323 active site 1 [active] 405535010324 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 405535010325 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 405535010326 generic binding surface II; other site 405535010327 ssDNA binding site; other site 405535010328 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405535010329 ATP binding site [chemical binding]; other site 405535010330 putative Mg++ binding site [ion binding]; other site 405535010331 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405535010332 nucleotide binding region [chemical binding]; other site 405535010333 ATP-binding site [chemical binding]; other site 405535010334 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 405535010335 DAK2 domain; Region: Dak2; pfam02734 405535010336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 405535010337 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 405535010338 Thiamine pyrophosphokinase; Region: TPK; cd07995 405535010339 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 405535010340 active site 405535010341 dimerization interface [polypeptide binding]; other site 405535010342 thiamine binding site [chemical binding]; other site 405535010343 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 405535010344 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 405535010345 substrate binding site [chemical binding]; other site 405535010346 hexamer interface [polypeptide binding]; other site 405535010347 metal binding site [ion binding]; metal-binding site 405535010348 GTPase RsgA; Reviewed; Region: PRK00098 405535010349 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 405535010350 RNA binding site [nucleotide binding]; other site 405535010351 homodimer interface [polypeptide binding]; other site 405535010352 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 405535010353 GTPase/Zn-binding domain interface [polypeptide binding]; other site 405535010354 GTP/Mg2+ binding site [chemical binding]; other site 405535010355 G4 box; other site 405535010356 G5 box; other site 405535010357 G1 box; other site 405535010358 Switch I region; other site 405535010359 G2 box; other site 405535010360 G3 box; other site 405535010361 Switch II region; other site 405535010362 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 405535010363 Catalytic domain of Protein Kinases; Region: PKc; cd00180 405535010364 active site 405535010365 ATP binding site [chemical binding]; other site 405535010366 substrate binding site [chemical binding]; other site 405535010367 activation loop (A-loop); other site 405535010368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 405535010369 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 405535010370 PASTA domain; Region: PASTA; pfam03793 405535010371 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 405535010372 Protein phosphatase 2C; Region: PP2C; pfam00481 405535010373 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 405535010374 active site 405535010375 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 405535010376 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405535010377 FeS/SAM binding site; other site 405535010378 16S rRNA methyltransferase B; Provisional; Region: PRK14902 405535010379 NusB family; Region: NusB; pfam01029 405535010380 putative RNA binding site [nucleotide binding]; other site 405535010381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535010382 S-adenosylmethionine binding site [chemical binding]; other site 405535010383 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 405535010384 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 405535010385 putative active site [active] 405535010386 substrate binding site [chemical binding]; other site 405535010387 putative cosubstrate binding site; other site 405535010388 catalytic site [active] 405535010389 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 405535010390 substrate binding site [chemical binding]; other site 405535010391 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 405535010392 active site 405535010393 catalytic residues [active] 405535010394 metal binding site [ion binding]; metal-binding site 405535010395 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405535010396 primosomal protein N' Region: priA; TIGR00595 405535010397 ATP binding site [chemical binding]; other site 405535010398 putative Mg++ binding site [ion binding]; other site 405535010399 helicase superfamily c-terminal domain; Region: HELICc; smart00490 405535010400 nucleotide binding region [chemical binding]; other site 405535010401 ATP-binding site [chemical binding]; other site 405535010402 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 405535010403 Flavoprotein; Region: Flavoprotein; pfam02441 405535010404 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 405535010405 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 405535010406 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 405535010407 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 405535010408 catalytic site [active] 405535010409 G-X2-G-X-G-K; other site 405535010410 hypothetical protein; Provisional; Region: PRK04323 405535010411 hypothetical protein; Provisional; Region: PRK11820 405535010412 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 405535010413 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 405535010414 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 405535010415 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 405535010416 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405535010417 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 405535010418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535010419 motif II; other site 405535010420 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 405535010421 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 405535010422 Domain of unknown function (DUF814); Region: DUF814; pfam05670 405535010423 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 405535010424 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 405535010425 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 405535010426 active site 405535010427 Protein of unknown function (DUF664); Region: DUF664; pfam04978 405535010428 DinB superfamily; Region: DinB_2; pfam12867 405535010429 YoqO-like protein; Region: YoqO; pfam14037 405535010430 YoqO-like protein; Region: YoqO; pfam14037 405535010431 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 405535010432 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 405535010433 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405535010434 active site 405535010435 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 405535010436 active site 405535010437 dimer interface [polypeptide binding]; other site 405535010438 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 405535010439 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 405535010440 heterodimer interface [polypeptide binding]; other site 405535010441 active site 405535010442 FMN binding site [chemical binding]; other site 405535010443 homodimer interface [polypeptide binding]; other site 405535010444 substrate binding site [chemical binding]; other site 405535010445 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 405535010446 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 405535010447 FAD binding pocket [chemical binding]; other site 405535010448 FAD binding motif [chemical binding]; other site 405535010449 phosphate binding motif [ion binding]; other site 405535010450 beta-alpha-beta structure motif; other site 405535010451 NAD binding pocket [chemical binding]; other site 405535010452 Iron coordination center [ion binding]; other site 405535010453 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 405535010454 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405535010455 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 405535010456 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 405535010457 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405535010458 ATP-grasp domain; Region: ATP-grasp_4; cl17255 405535010459 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 405535010460 IMP binding site; other site 405535010461 dimer interface [polypeptide binding]; other site 405535010462 interdomain contacts; other site 405535010463 partial ornithine binding site; other site 405535010464 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 405535010465 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 405535010466 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 405535010467 catalytic site [active] 405535010468 subunit interface [polypeptide binding]; other site 405535010469 dihydroorotase; Validated; Region: pyrC; PRK09357 405535010470 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 405535010471 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 405535010472 active site 405535010473 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 405535010474 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 405535010475 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 405535010476 PyrR binding site 405535010477 uracil transporter; Provisional; Region: PRK10720 405535010478 PyrR binding site 405535010479 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 405535010480 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405535010481 active site 405535010482 PyrR binding site 405535010483 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 405535010484 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405535010485 RNA binding surface [nucleotide binding]; other site 405535010486 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 405535010487 active site 405535010488 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 405535010489 lipoprotein signal peptidase; Provisional; Region: PRK14787 405535010490 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 405535010491 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 405535010492 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 405535010493 active site 405535010494 HIGH motif; other site 405535010495 nucleotide binding site [chemical binding]; other site 405535010496 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 405535010497 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 405535010498 active site 405535010499 KMSKS motif; other site 405535010500 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 405535010501 tRNA binding surface [nucleotide binding]; other site 405535010502 anticodon binding site; other site 405535010503 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 405535010504 DivIVA protein; Region: DivIVA; pfam05103 405535010505 DivIVA domain; Region: DivI1A_domain; TIGR03544 405535010506 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 405535010507 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 405535010508 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405535010509 RNA binding surface [nucleotide binding]; other site 405535010510 YGGT family; Region: YGGT; pfam02325 405535010511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 405535010512 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 405535010513 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405535010514 catalytic residue [active] 405535010515 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 405535010516 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 405535010517 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 405535010518 sporulation sigma factor SigG; Reviewed; Region: PRK08215 405535010519 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535010520 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405535010521 DNA binding residues [nucleotide binding] 405535010522 sporulation sigma factor SigE; Reviewed; Region: PRK08301 405535010523 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535010524 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405535010525 DNA binding residues [nucleotide binding] 405535010526 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 405535010527 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 405535010528 cell division protein FtsZ; Validated; Region: PRK09330 405535010529 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 405535010530 nucleotide binding site [chemical binding]; other site 405535010531 SulA interaction site; other site 405535010532 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 405535010533 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405535010534 nucleotide binding site [chemical binding]; other site 405535010535 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 405535010536 Cell division protein FtsA; Region: FtsA; pfam14450 405535010537 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 405535010538 Cell division protein FtsQ; Region: FtsQ; pfam03799 405535010539 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 405535010540 FAD binding domain; Region: FAD_binding_4; pfam01565 405535010541 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 405535010542 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 405535010543 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 405535010544 active site 405535010545 homodimer interface [polypeptide binding]; other site 405535010546 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 405535010547 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 405535010548 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 405535010549 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405535010550 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405535010551 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 405535010552 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 405535010553 Mg++ binding site [ion binding]; other site 405535010554 putative catalytic motif [active] 405535010555 putative substrate binding site [chemical binding]; other site 405535010556 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 405535010557 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 405535010558 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405535010559 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405535010560 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 405535010561 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405535010562 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405535010563 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 405535010564 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405535010565 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405535010566 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405535010567 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 405535010568 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 405535010569 Cell division protein FtsL; Region: FtsL; cl11433 405535010570 MraW methylase family; Region: Methyltransf_5; pfam01795 405535010571 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 405535010572 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 405535010573 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 405535010574 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 405535010575 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 405535010576 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 405535010577 hypothetical protein; Provisional; Region: PRK13688 405535010578 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535010579 Coenzyme A binding pocket [chemical binding]; other site 405535010580 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 405535010581 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 405535010582 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 405535010583 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 405535010584 hypothetical protein; Provisional; Region: PRK13670 405535010585 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 405535010586 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 405535010587 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 405535010588 protein binding site [polypeptide binding]; other site 405535010589 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 405535010590 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 405535010591 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 405535010592 active site 405535010593 nucleophile elbow; other site 405535010594 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 405535010595 Nucleoside recognition; Region: Gate; pfam07670 405535010596 Nucleoside recognition; Region: Gate; pfam07670 405535010597 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 405535010598 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 405535010599 active site 405535010600 (T/H)XGH motif; other site 405535010601 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 405535010602 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535010603 S-adenosylmethionine binding site [chemical binding]; other site 405535010604 ylbH leader 405535010605 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 405535010606 Protein of unknown function (DUF964); Region: DUF964; pfam06133 405535010607 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405535010608 catalytic core [active] 405535010609 YlbE-like protein; Region: YlbE; pfam14003 405535010610 Putative coat protein; Region: YlbD_coat; pfam14071 405535010611 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 405535010612 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 405535010613 YugN-like family; Region: YugN; pfam08868 405535010614 formamidase; Provisional; Region: amiF; PRK13287 405535010615 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 405535010616 multimer interface [polypeptide binding]; other site 405535010617 active site 405535010618 catalytic triad [active] 405535010619 dimer interface [polypeptide binding]; other site 405535010620 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 405535010621 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 405535010622 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 405535010623 Subunit I/III interface [polypeptide binding]; other site 405535010624 Subunit III/IV interface [polypeptide binding]; other site 405535010625 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 405535010626 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 405535010627 D-pathway; other site 405535010628 Putative ubiquinol binding site [chemical binding]; other site 405535010629 Low-spin heme (heme b) binding site [chemical binding]; other site 405535010630 Putative water exit pathway; other site 405535010631 Binuclear center (heme o3/CuB) [ion binding]; other site 405535010632 K-pathway; other site 405535010633 Putative proton exit pathway; other site 405535010634 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 405535010635 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 405535010636 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 405535010637 Cytochrome c; Region: Cytochrom_C; pfam00034 405535010638 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 405535010639 UbiA prenyltransferase family; Region: UbiA; pfam01040 405535010640 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 405535010641 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 405535010642 pyruvate carboxylase; Reviewed; Region: PRK12999 405535010643 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405535010644 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 405535010645 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 405535010646 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 405535010647 active site 405535010648 catalytic residues [active] 405535010649 metal binding site [ion binding]; metal-binding site 405535010650 homodimer binding site [polypeptide binding]; other site 405535010651 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 405535010652 carboxyltransferase (CT) interaction site; other site 405535010653 biotinylation site [posttranslational modification]; other site 405535010654 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 405535010655 hypothetical protein; Provisional; Region: PRK13666 405535010656 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 405535010657 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 405535010658 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 405535010659 putative active site [active] 405535010660 PhoH-like protein; Region: PhoH; pfam02562 405535010661 hypothetical protein; Provisional; Region: PRK06733 405535010662 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 405535010663 YlaH-like protein; Region: YlaH; pfam14036 405535010664 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 405535010665 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 405535010666 G1 box; other site 405535010667 putative GEF interaction site [polypeptide binding]; other site 405535010668 GTP/Mg2+ binding site [chemical binding]; other site 405535010669 Switch I region; other site 405535010670 G2 box; other site 405535010671 G3 box; other site 405535010672 Switch II region; other site 405535010673 G4 box; other site 405535010674 G5 box; other site 405535010675 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 405535010676 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 405535010677 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 405535010678 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 405535010679 active site 405535010680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 405535010681 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 405535010682 hypothetical protein; Provisional; Region: PRK04387 405535010683 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 405535010684 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 405535010685 homodimer interface [polypeptide binding]; other site 405535010686 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535010687 catalytic residue [active] 405535010688 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 405535010689 transglutaminase; Provisional; Region: tgl; PRK03187 405535010690 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 405535010691 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 405535010692 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 405535010693 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 405535010694 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 405535010695 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 405535010696 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405535010697 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405535010698 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 405535010699 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405535010700 E3 interaction surface; other site 405535010701 lipoyl attachment site [posttranslational modification]; other site 405535010702 e3 binding domain; Region: E3_binding; pfam02817 405535010703 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 405535010704 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 405535010705 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 405535010706 alpha subunit interface [polypeptide binding]; other site 405535010707 TPP binding site [chemical binding]; other site 405535010708 heterodimer interface [polypeptide binding]; other site 405535010709 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405535010710 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 405535010711 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 405535010712 TPP-binding site [chemical binding]; other site 405535010713 heterodimer interface [polypeptide binding]; other site 405535010714 tetramer interface [polypeptide binding]; other site 405535010715 phosphorylation loop region [posttranslational modification] 405535010716 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 405535010717 active site 405535010718 catalytic residues [active] 405535010719 metal binding site [ion binding]; metal-binding site 405535010720 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535010721 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405535010722 active site 405535010723 motif I; other site 405535010724 motif II; other site 405535010725 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535010726 hypothetical protein; Provisional; Region: PRK13667 405535010727 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 405535010728 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405535010729 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 405535010730 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 405535010731 TrkA-N domain; Region: TrkA_N; pfam02254 405535010732 TrkA-C domain; Region: TrkA_C; pfam02080 405535010733 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 405535010734 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405535010735 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 405535010736 metal binding site [ion binding]; metal-binding site 405535010737 putative dimer interface [polypeptide binding]; other site 405535010738 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 405535010739 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 405535010740 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 405535010741 trimer interface [polypeptide binding]; other site 405535010742 active site 405535010743 substrate binding site [chemical binding]; other site 405535010744 CoA binding site [chemical binding]; other site 405535010745 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405535010746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405535010747 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405535010748 dimerization interface [polypeptide binding]; other site 405535010749 FOG: CBS domain [General function prediction only]; Region: COG0517 405535010750 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 405535010751 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 405535010752 Protein of unknown function (DUF458); Region: DUF458; pfam04308 405535010753 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 405535010754 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 405535010755 catalytic residues [active] 405535010756 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 405535010757 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405535010758 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 405535010759 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 405535010760 short chain dehydrogenase; Provisional; Region: PRK07677 405535010761 NAD(P) binding site [chemical binding]; other site 405535010762 substrate binding site [chemical binding]; other site 405535010763 homotetramer interface [polypeptide binding]; other site 405535010764 active site 405535010765 homodimer interface [polypeptide binding]; other site 405535010766 phosphodiesterase YaeI; Provisional; Region: PRK11340 405535010767 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 405535010768 putative active site [active] 405535010769 putative metal binding site [ion binding]; other site 405535010770 polyphosphate kinase; Provisional; Region: PRK05443 405535010771 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 405535010772 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 405535010773 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 405535010774 putative domain interface [polypeptide binding]; other site 405535010775 putative active site [active] 405535010776 catalytic site [active] 405535010777 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 405535010778 putative domain interface [polypeptide binding]; other site 405535010779 putative active site [active] 405535010780 catalytic site [active] 405535010781 exopolyphosphatase; Region: exo_poly_only; TIGR03706 405535010782 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405535010783 nucleotide binding site [chemical binding]; other site 405535010784 YkyB-like protein; Region: YkyB; pfam14177 405535010785 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 405535010786 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405535010787 I-site; other site 405535010788 active site 405535010789 metal binding site [ion binding]; metal-binding site 405535010790 Phage lysis protein, holin; Region: Phage_holin; cl04675 405535010791 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405535010792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535010793 putative substrate translocation pore; other site 405535010794 Predicted transcriptional regulators [Transcription]; Region: COG1695 405535010795 Transcriptional regulator PadR-like family; Region: PadR; cl17335 405535010796 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405535010797 nudix motif; other site 405535010798 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 405535010799 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 405535010800 THF binding site; other site 405535010801 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 405535010802 substrate binding site [chemical binding]; other site 405535010803 THF binding site; other site 405535010804 zinc-binding site [ion binding]; other site 405535010805 Competence protein J (ComJ); Region: ComJ; pfam11033 405535010806 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 405535010807 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 405535010808 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535010809 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535010810 dimer interface [polypeptide binding]; other site 405535010811 phosphorylation site [posttranslational modification] 405535010812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535010813 ATP binding site [chemical binding]; other site 405535010814 Mg2+ binding site [ion binding]; other site 405535010815 G-X-G motif; other site 405535010816 aminotransferase A; Validated; Region: PRK07683 405535010817 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405535010818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535010819 homodimer interface [polypeptide binding]; other site 405535010820 catalytic residue [active] 405535010821 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405535010822 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405535010823 DNA binding site [nucleotide binding] 405535010824 domain linker motif; other site 405535010825 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 405535010826 putative dimerization interface [polypeptide binding]; other site 405535010827 putative ligand binding site [chemical binding]; other site 405535010828 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 405535010829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535010830 dimer interface [polypeptide binding]; other site 405535010831 conserved gate region; other site 405535010832 putative PBP binding loops; other site 405535010833 ABC-ATPase subunit interface; other site 405535010834 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 405535010835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535010836 dimer interface [polypeptide binding]; other site 405535010837 conserved gate region; other site 405535010838 putative PBP binding loops; other site 405535010839 ABC-ATPase subunit interface; other site 405535010840 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 405535010841 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 405535010842 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 405535010843 homodimer interface [polypeptide binding]; other site 405535010844 maltodextrin glucosidase; Provisional; Region: PRK10785 405535010845 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 405535010846 active site 405535010847 homodimer interface [polypeptide binding]; other site 405535010848 catalytic site [active] 405535010849 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 405535010850 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 405535010851 Ca binding site [ion binding]; other site 405535010852 active site 405535010853 catalytic site [active] 405535010854 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 405535010855 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 405535010856 Walker A/P-loop; other site 405535010857 ATP binding site [chemical binding]; other site 405535010858 Q-loop/lid; other site 405535010859 ABC transporter signature motif; other site 405535010860 Walker B; other site 405535010861 D-loop; other site 405535010862 H-loop/switch region; other site 405535010863 TOBE domain; Region: TOBE_2; pfam08402 405535010864 hypothetical protein; Provisional; Region: PRK06720 405535010865 NAD(P) binding site [chemical binding]; other site 405535010866 RDD family; Region: RDD; pfam06271 405535010867 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 405535010868 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 405535010869 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 405535010870 Predicted ATPase [General function prediction only]; Region: COG3910 405535010871 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535010872 Walker A/P-loop; other site 405535010873 ATP binding site [chemical binding]; other site 405535010874 Q-loop/lid; other site 405535010875 ABC transporter signature motif; other site 405535010876 Walker B; other site 405535010877 D-loop; other site 405535010878 H-loop/switch region; other site 405535010879 putative acyltransferase; Provisional; Region: PRK05790 405535010880 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 405535010881 dimer interface [polypeptide binding]; other site 405535010882 active site 405535010883 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 405535010884 nudix motif; other site 405535010885 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 405535010886 hypothetical protein; Validated; Region: PRK07668 405535010887 hypothetical protein; Validated; Region: PRK07668 405535010888 hypothetical protein; Validated; Region: PRK07668 405535010889 Predicted transcriptional regulators [Transcription]; Region: COG1695 405535010890 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405535010891 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 405535010892 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405535010893 NAD(P) binding site [chemical binding]; other site 405535010894 active site 405535010895 YvrJ protein family; Region: YvrJ; pfam12841 405535010896 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 405535010897 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 405535010898 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 405535010899 Phosphotransferase enzyme family; Region: APH; pfam01636 405535010900 Predicted amidohydrolase [General function prediction only]; Region: COG0388 405535010901 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 405535010902 putative active site [active] 405535010903 catalytic triad [active] 405535010904 putative dimer interface [polypeptide binding]; other site 405535010905 transaminase; Reviewed; Region: PRK08068 405535010906 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405535010907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535010908 homodimer interface [polypeptide binding]; other site 405535010909 catalytic residue [active] 405535010910 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 405535010911 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 405535010912 dimer interface [polypeptide binding]; other site 405535010913 active site 405535010914 catalytic residue [active] 405535010915 metal binding site [ion binding]; metal-binding site 405535010916 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 405535010917 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 405535010918 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 405535010919 intersubunit interface [polypeptide binding]; other site 405535010920 active site 405535010921 Zn2+ binding site [ion binding]; other site 405535010922 ARD/ARD' family; Region: ARD; pfam03079 405535010923 Cupin domain; Region: Cupin_2; pfam07883 405535010924 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 405535010925 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 405535010926 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405535010927 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405535010928 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405535010929 metal binding site [ion binding]; metal-binding site 405535010930 active site 405535010931 I-site; other site 405535010932 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 405535010933 dimer interface [polypeptide binding]; other site 405535010934 FMN binding site [chemical binding]; other site 405535010935 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 405535010936 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 405535010937 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 405535010938 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 405535010939 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 405535010940 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 405535010941 dimerization domain swap beta strand [polypeptide binding]; other site 405535010942 regulatory protein interface [polypeptide binding]; other site 405535010943 active site 405535010944 regulatory phosphorylation site [posttranslational modification]; other site 405535010945 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405535010946 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 405535010947 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405535010948 active site turn [active] 405535010949 phosphorylation site [posttranslational modification] 405535010950 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 405535010951 HPr interaction site; other site 405535010952 glycerol kinase (GK) interaction site [polypeptide binding]; other site 405535010953 active site 405535010954 phosphorylation site [posttranslational modification] 405535010955 transcriptional antiterminator BglG; Provisional; Region: PRK09772 405535010956 CAT RNA binding domain; Region: CAT_RBD; smart01061 405535010957 PRD domain; Region: PRD; pfam00874 405535010958 PRD domain; Region: PRD; pfam00874 405535010959 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405535010960 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535010961 active site 405535010962 motif I; other site 405535010963 motif II; other site 405535010964 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535010965 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 405535010966 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535010967 DNA-binding site [nucleotide binding]; DNA binding site 405535010968 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 405535010969 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 405535010970 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 405535010971 active site 405535010972 trimer interface [polypeptide binding]; other site 405535010973 allosteric site; other site 405535010974 active site lid [active] 405535010975 hexamer (dimer of trimers) interface [polypeptide binding]; other site 405535010976 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 405535010977 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 405535010978 active site 405535010979 dimer interface [polypeptide binding]; other site 405535010980 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 405535010981 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405535010982 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 405535010983 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 405535010984 Domain of unknown function (DUF309); Region: DUF309; pfam03745 405535010985 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535010986 Coenzyme A binding pocket [chemical binding]; other site 405535010987 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 405535010988 active site 405535010989 Predicted secreted protein [Function unknown]; Region: COG4086 405535010990 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 405535010991 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405535010992 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 405535010993 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 405535010994 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405535010995 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 405535010996 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 405535010997 stage V sporulation protein AD; Validated; Region: PRK08304 405535010998 stage V sporulation protein AD; Provisional; Region: PRK12404 405535010999 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 405535011000 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 405535011001 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 405535011002 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 405535011003 Na2 binding site [ion binding]; other site 405535011004 putative substrate binding site 1 [chemical binding]; other site 405535011005 Na binding site 1 [ion binding]; other site 405535011006 putative substrate binding site 2 [chemical binding]; other site 405535011007 sporulation sigma factor SigF; Validated; Region: PRK05572 405535011008 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535011009 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 405535011010 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405535011011 DNA binding residues [nucleotide binding] 405535011012 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 405535011013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535011014 ATP binding site [chemical binding]; other site 405535011015 Mg2+ binding site [ion binding]; other site 405535011016 G-X-G motif; other site 405535011017 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 405535011018 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 405535011019 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405535011020 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 405535011021 Predicted transcriptional regulators [Transcription]; Region: COG1725 405535011022 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535011023 DNA-binding site [nucleotide binding]; DNA binding site 405535011024 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405535011025 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405535011026 Walker A/P-loop; other site 405535011027 ATP binding site [chemical binding]; other site 405535011028 Q-loop/lid; other site 405535011029 ABC transporter signature motif; other site 405535011030 Walker B; other site 405535011031 D-loop; other site 405535011032 H-loop/switch region; other site 405535011033 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405535011034 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 405535011035 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405535011036 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405535011037 MarR family; Region: MarR; pfam01047 405535011038 MarR family; Region: MarR_2; cl17246 405535011039 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 405535011040 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 405535011041 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405535011042 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 405535011043 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 405535011044 oligomer interface [polypeptide binding]; other site 405535011045 metal binding site [ion binding]; metal-binding site 405535011046 metal binding site [ion binding]; metal-binding site 405535011047 putative Cl binding site [ion binding]; other site 405535011048 aspartate ring; other site 405535011049 basic sphincter; other site 405535011050 hydrophobic gate; other site 405535011051 periplasmic entrance; other site 405535011052 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 405535011053 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 405535011054 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 405535011055 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 405535011056 purine nucleoside phosphorylase; Provisional; Region: PRK08202 405535011057 phosphopentomutase; Provisional; Region: PRK05362 405535011058 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 405535011059 YtkA-like; Region: YtkA; pfam13115 405535011060 YtkA-like; Region: YtkA; pfam13115 405535011061 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 405535011062 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 405535011063 active site 405535011064 Int/Topo IB signature motif; other site 405535011065 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 405535011066 ferric uptake regulator; Provisional; Region: fur; PRK09462 405535011067 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 405535011068 metal binding site 2 [ion binding]; metal-binding site 405535011069 putative DNA binding helix; other site 405535011070 metal binding site 1 [ion binding]; metal-binding site 405535011071 dimer interface [polypeptide binding]; other site 405535011072 structural Zn2+ binding site [ion binding]; other site 405535011073 stage II sporulation protein M; Region: spo_II_M; TIGR02831 405535011074 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405535011075 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405535011076 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 405535011077 dimer interface [polypeptide binding]; other site 405535011078 ADP-ribose binding site [chemical binding]; other site 405535011079 active site 405535011080 nudix motif; other site 405535011081 metal binding site [ion binding]; metal-binding site 405535011082 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 405535011083 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405535011084 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405535011085 active site 405535011086 catalytic tetrad [active] 405535011087 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405535011088 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405535011089 active site 405535011090 catalytic tetrad [active] 405535011091 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 405535011092 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 405535011093 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 405535011094 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 405535011095 putative active site [active] 405535011096 putative metal binding site [ion binding]; other site 405535011097 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405535011098 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 405535011099 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 405535011100 Predicted permease [General function prediction only]; Region: COG2056 405535011101 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 405535011102 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 405535011103 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405535011104 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405535011105 DNA binding site [nucleotide binding] 405535011106 domain linker motif; other site 405535011107 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 405535011108 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405535011109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535011110 Coenzyme A binding pocket [chemical binding]; other site 405535011111 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 405535011112 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 405535011113 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 405535011114 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 405535011115 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 405535011116 catalytic motif [active] 405535011117 Zn binding site [ion binding]; other site 405535011118 RibD C-terminal domain; Region: RibD_C; cl17279 405535011119 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 405535011120 Lumazine binding domain; Region: Lum_binding; pfam00677 405535011121 Lumazine binding domain; Region: Lum_binding; pfam00677 405535011122 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 405535011123 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 405535011124 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 405535011125 dimerization interface [polypeptide binding]; other site 405535011126 active site 405535011127 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 405535011128 homopentamer interface [polypeptide binding]; other site 405535011129 active site 405535011130 biotin synthase; Validated; Region: PRK06256 405535011131 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405535011132 FeS/SAM binding site; other site 405535011133 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 405535011134 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 405535011135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535011136 S-adenosylmethionine binding site [chemical binding]; other site 405535011137 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405535011138 TAP-like protein; Region: Abhydrolase_4; pfam08386 405535011139 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 405535011140 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 405535011141 substrate-cofactor binding pocket; other site 405535011142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535011143 catalytic residue [active] 405535011144 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 405535011145 AAA domain; Region: AAA_26; pfam13500 405535011146 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 405535011147 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405535011148 inhibitor-cofactor binding pocket; inhibition site 405535011149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535011150 catalytic residue [active] 405535011151 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 405535011152 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 405535011153 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 405535011154 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 405535011155 active site 405535011156 metal binding site [ion binding]; metal-binding site 405535011157 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405535011158 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 405535011159 active site 405535011160 catalytic triad [active] 405535011161 oxyanion hole [active] 405535011162 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535011163 dimerization interface [polypeptide binding]; other site 405535011164 putative DNA binding site [nucleotide binding]; other site 405535011165 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405535011166 putative Zn2+ binding site [ion binding]; other site 405535011167 ornithine carbamoyltransferase; Provisional; Region: PRK00779 405535011168 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 405535011169 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 405535011170 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 405535011171 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405535011172 inhibitor-cofactor binding pocket; inhibition site 405535011173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535011174 catalytic residue [active] 405535011175 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 405535011176 nucleotide binding site [chemical binding]; other site 405535011177 N-acetyl-L-glutamate binding site [chemical binding]; other site 405535011178 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 405535011179 heterotetramer interface [polypeptide binding]; other site 405535011180 active site pocket [active] 405535011181 cleavage site 405535011182 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 405535011183 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 405535011184 YqzH-like protein; Region: YqzH; pfam14164 405535011185 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 405535011186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405535011187 NAD(P) binding site [chemical binding]; other site 405535011188 active site 405535011189 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405535011190 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 405535011191 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 405535011192 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 405535011193 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 405535011194 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 405535011195 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 405535011196 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 405535011197 putative L-serine binding site [chemical binding]; other site 405535011198 ribonuclease Z; Region: RNase_Z; TIGR02651 405535011199 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 405535011200 DNA polymerase IV; Validated; Region: PRK01810 405535011201 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 405535011202 active site 405535011203 DNA binding site [nucleotide binding] 405535011204 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 405535011205 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 405535011206 peptidase T-like protein; Region: PepT-like; TIGR01883 405535011207 metal binding site [ion binding]; metal-binding site 405535011208 putative dimer interface [polypeptide binding]; other site 405535011209 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405535011210 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405535011211 Protein of unknown function (DUF3894); Region: DUF3894; pfam13033 405535011212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 405535011213 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405535011214 Predicted membrane protein [Function unknown]; Region: COG4129 405535011215 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 405535011216 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 405535011217 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405535011218 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405535011219 Walker A/P-loop; other site 405535011220 ATP binding site [chemical binding]; other site 405535011221 Q-loop/lid; other site 405535011222 ABC transporter signature motif; other site 405535011223 Walker B; other site 405535011224 D-loop; other site 405535011225 H-loop/switch region; other site 405535011226 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 405535011227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535011228 dimer interface [polypeptide binding]; other site 405535011229 conserved gate region; other site 405535011230 putative PBP binding loops; other site 405535011231 ABC-ATPase subunit interface; other site 405535011232 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 405535011233 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405535011234 substrate binding pocket [chemical binding]; other site 405535011235 membrane-bound complex binding site; other site 405535011236 hinge residues; other site 405535011237 Disulphide isomerase; Region: Disulph_isomer; pfam06491 405535011238 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 405535011239 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 405535011240 nudix motif; other site 405535011241 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 405535011242 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 405535011243 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405535011244 E3 interaction surface; other site 405535011245 lipoyl attachment site [posttranslational modification]; other site 405535011246 e3 binding domain; Region: E3_binding; pfam02817 405535011247 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 405535011248 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 405535011249 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 405535011250 alpha subunit interface [polypeptide binding]; other site 405535011251 TPP binding site [chemical binding]; other site 405535011252 heterodimer interface [polypeptide binding]; other site 405535011253 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405535011254 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 405535011255 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 405535011256 tetramer interface [polypeptide binding]; other site 405535011257 TPP-binding site [chemical binding]; other site 405535011258 heterodimer interface [polypeptide binding]; other site 405535011259 phosphorylation loop region [posttranslational modification] 405535011260 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 405535011261 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 405535011262 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405535011263 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405535011264 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405535011265 nucleotide binding site [chemical binding]; other site 405535011266 Acetokinase family; Region: Acetate_kinase; cl17229 405535011267 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 405535011268 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 405535011269 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 405535011270 NAD binding site [chemical binding]; other site 405535011271 Phe binding site; other site 405535011272 phosphate butyryltransferase; Validated; Region: PRK07742 405535011273 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 405535011274 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405535011275 putative active site [active] 405535011276 heme pocket [chemical binding]; other site 405535011277 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405535011278 putative active site [active] 405535011279 heme pocket [chemical binding]; other site 405535011280 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535011281 Walker A motif; other site 405535011282 ATP binding site [chemical binding]; other site 405535011283 Walker B motif; other site 405535011284 arginine finger; other site 405535011285 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405535011286 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 405535011287 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 405535011288 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 405535011289 active site 405535011290 catalytic site [active] 405535011291 metal binding site [ion binding]; metal-binding site 405535011292 dimer interface [polypeptide binding]; other site 405535011293 YycC-like protein; Region: YycC; pfam14174 405535011294 conserved hypothetical integral membrane protein; Region: TIGR03766 405535011295 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 405535011296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535011297 active site 405535011298 phosphorylation site [posttranslational modification] 405535011299 intermolecular recognition site; other site 405535011300 dimerization interface [polypeptide binding]; other site 405535011301 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 405535011302 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 405535011303 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 405535011304 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 405535011305 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 405535011306 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 405535011307 Walker A/P-loop; other site 405535011308 ATP binding site [chemical binding]; other site 405535011309 Q-loop/lid; other site 405535011310 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 405535011311 ABC transporter signature motif; other site 405535011312 Walker B; other site 405535011313 D-loop; other site 405535011314 H-loop/switch region; other site 405535011315 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 405535011316 arginine repressor; Provisional; Region: PRK04280 405535011317 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 405535011318 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 405535011319 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405535011320 RNA binding surface [nucleotide binding]; other site 405535011321 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 405535011322 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 405535011323 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 405535011324 TPP-binding site; other site 405535011325 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 405535011326 PYR/PP interface [polypeptide binding]; other site 405535011327 dimer interface [polypeptide binding]; other site 405535011328 TPP binding site [chemical binding]; other site 405535011329 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405535011330 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 405535011331 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 405535011332 substrate binding pocket [chemical binding]; other site 405535011333 chain length determination region; other site 405535011334 substrate-Mg2+ binding site; other site 405535011335 catalytic residues [active] 405535011336 aspartate-rich region 1; other site 405535011337 active site lid residues [active] 405535011338 aspartate-rich region 2; other site 405535011339 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 405535011340 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 405535011341 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 405535011342 generic binding surface II; other site 405535011343 generic binding surface I; other site 405535011344 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 405535011345 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 405535011346 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 405535011347 homodimer interface [polypeptide binding]; other site 405535011348 NADP binding site [chemical binding]; other site 405535011349 substrate binding site [chemical binding]; other site 405535011350 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 405535011351 putative RNA binding site [nucleotide binding]; other site 405535011352 Asp23 family; Region: Asp23; pfam03780 405535011353 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 405535011354 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405535011355 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 405535011356 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 405535011357 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 405535011358 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 405535011359 carboxyltransferase (CT) interaction site; other site 405535011360 biotinylation site [posttranslational modification]; other site 405535011361 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 405535011362 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 405535011363 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 405535011364 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 405535011365 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 405535011366 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 405535011367 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 405535011368 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 405535011369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535011370 Walker A motif; other site 405535011371 ATP binding site [chemical binding]; other site 405535011372 Walker B motif; other site 405535011373 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 405535011374 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405535011375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405535011376 elongation factor P; Validated; Region: PRK00529 405535011377 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 405535011378 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 405535011379 RNA binding site [nucleotide binding]; other site 405535011380 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 405535011381 RNA binding site [nucleotide binding]; other site 405535011382 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 405535011383 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 405535011384 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 405535011385 active site 405535011386 Dehydroquinase class II; Region: DHquinase_II; pfam01220 405535011387 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 405535011388 trimer interface [polypeptide binding]; other site 405535011389 active site 405535011390 dimer interface [polypeptide binding]; other site 405535011391 Conserved membrane protein YqhR; Region: YqhR; pfam11085 405535011392 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 405535011393 CCC1-related family of proteins; Region: CCC1_like; cl00278 405535011394 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 405535011395 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 405535011396 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535011397 motif II; other site 405535011398 manganese transport transcriptional regulator; Provisional; Region: PRK03902 405535011399 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 405535011400 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 405535011401 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 405535011402 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405535011403 FeS/SAM binding site; other site 405535011404 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 405535011405 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405535011406 active site residue [active] 405535011407 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405535011408 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405535011409 DNA binding site [nucleotide binding] 405535011410 domain linker motif; other site 405535011411 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 405535011412 putative dimerization interface [polypeptide binding]; other site 405535011413 putative ligand binding site [chemical binding]; other site 405535011414 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535011415 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535011416 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405535011417 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405535011418 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 405535011419 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 405535011420 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 405535011421 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 405535011422 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 405535011423 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405535011424 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405535011425 Walker A/P-loop; other site 405535011426 ATP binding site [chemical binding]; other site 405535011427 Q-loop/lid; other site 405535011428 ABC transporter signature motif; other site 405535011429 Walker B; other site 405535011430 D-loop; other site 405535011431 H-loop/switch region; other site 405535011432 Predicted transcriptional regulators [Transcription]; Region: COG1725 405535011433 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535011434 DNA-binding site [nucleotide binding]; DNA binding site 405535011435 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 405535011436 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 405535011437 tetramer interface [polypeptide binding]; other site 405535011438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535011439 catalytic residue [active] 405535011440 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 405535011441 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 405535011442 tetramer interface [polypeptide binding]; other site 405535011443 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535011444 catalytic residue [active] 405535011445 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 405535011446 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 405535011447 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 405535011448 DEAD-like helicases superfamily; Region: DEXDc; smart00487 405535011449 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405535011450 ATP binding site [chemical binding]; other site 405535011451 putative Mg++ binding site [ion binding]; other site 405535011452 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405535011453 nucleotide binding region [chemical binding]; other site 405535011454 ATP-binding site [chemical binding]; other site 405535011455 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 405535011456 YqzE-like protein; Region: YqzE; pfam14038 405535011457 shikimate kinase; Reviewed; Region: aroK; PRK00131 405535011458 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 405535011459 ADP binding site [chemical binding]; other site 405535011460 magnesium binding site [ion binding]; other site 405535011461 putative shikimate binding site; other site 405535011462 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 405535011463 ComG operon protein 7; Region: ComGG; pfam14173 405535011464 dihydroorotase; Provisional; Region: PRK04250 405535011465 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 405535011466 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 405535011467 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 405535011468 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 405535011469 Type II/IV secretion system protein; Region: T2SE; pfam00437 405535011470 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 405535011471 Walker A motif; other site 405535011472 ATP binding site [chemical binding]; other site 405535011473 Walker B motif; other site 405535011474 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535011475 putative DNA binding site [nucleotide binding]; other site 405535011476 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 405535011477 putative Zn2+ binding site [ion binding]; other site 405535011478 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 405535011479 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 405535011480 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405535011481 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 405535011482 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 405535011483 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405535011484 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 405535011485 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 405535011486 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 405535011487 active site 405535011488 homodimer interface [polypeptide binding]; other site 405535011489 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 405535011490 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 405535011491 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 405535011492 substrate binding pocket [chemical binding]; other site 405535011493 dimer interface [polypeptide binding]; other site 405535011494 inhibitor binding site; inhibition site 405535011495 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 405535011496 B12 binding site [chemical binding]; other site 405535011497 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 405535011498 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 405535011499 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 405535011500 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 405535011501 FAD binding site [chemical binding]; other site 405535011502 cystathionine gamma-synthase; Reviewed; Region: PRK08247 405535011503 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 405535011504 homodimer interface [polypeptide binding]; other site 405535011505 substrate-cofactor binding pocket; other site 405535011506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535011507 catalytic residue [active] 405535011508 cystathionine beta-lyase; Provisional; Region: PRK08064 405535011509 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 405535011510 homodimer interface [polypeptide binding]; other site 405535011511 substrate-cofactor binding pocket; other site 405535011512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535011513 catalytic residue [active] 405535011514 Isochorismatase family; Region: Isochorismatase; pfam00857 405535011515 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 405535011516 catalytic triad [active] 405535011517 conserved cis-peptide bond; other site 405535011518 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535011519 dimerization interface [polypeptide binding]; other site 405535011520 putative DNA binding site [nucleotide binding]; other site 405535011521 putative Zn2+ binding site [ion binding]; other site 405535011522 Uncharacterized conserved protein [Function unknown]; Region: COG1565 405535011523 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 405535011524 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 405535011525 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 405535011526 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405535011527 nucleotide binding site [chemical binding]; other site 405535011528 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 405535011529 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 405535011530 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 405535011531 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 405535011532 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 405535011533 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 405535011534 active site 405535011535 Substrate binding site; other site 405535011536 Mg++ binding site; other site 405535011537 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 405535011538 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 405535011539 active site 405535011540 metal binding site [ion binding]; metal-binding site 405535011541 substrate binding site [chemical binding]; other site 405535011542 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 405535011543 PhoU domain; Region: PhoU; pfam01895 405535011544 PhoU domain; Region: PhoU; pfam01895 405535011545 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 405535011546 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 405535011547 Walker A/P-loop; other site 405535011548 ATP binding site [chemical binding]; other site 405535011549 Q-loop/lid; other site 405535011550 ABC transporter signature motif; other site 405535011551 Walker B; other site 405535011552 D-loop; other site 405535011553 H-loop/switch region; other site 405535011554 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 405535011555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535011556 dimer interface [polypeptide binding]; other site 405535011557 conserved gate region; other site 405535011558 putative PBP binding loops; other site 405535011559 ABC-ATPase subunit interface; other site 405535011560 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 405535011561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535011562 dimer interface [polypeptide binding]; other site 405535011563 conserved gate region; other site 405535011564 putative PBP binding loops; other site 405535011565 ABC-ATPase subunit interface; other site 405535011566 PBP superfamily domain; Region: PBP_like_2; cl17296 405535011567 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405535011568 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405535011569 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405535011570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535011571 putative substrate translocation pore; other site 405535011572 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405535011573 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 405535011574 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 405535011575 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 405535011576 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 405535011577 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 405535011578 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 405535011579 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 405535011580 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 405535011581 metal binding site 2 [ion binding]; metal-binding site 405535011582 putative DNA binding helix; other site 405535011583 metal binding site 1 [ion binding]; metal-binding site 405535011584 dimer interface [polypeptide binding]; other site 405535011585 structural Zn2+ binding site [ion binding]; other site 405535011586 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 405535011587 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405535011588 ABC-ATPase subunit interface; other site 405535011589 dimer interface [polypeptide binding]; other site 405535011590 putative PBP binding regions; other site 405535011591 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 405535011592 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 405535011593 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405535011594 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405535011595 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405535011596 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 405535011597 endonuclease IV; Provisional; Region: PRK01060 405535011598 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 405535011599 AP (apurinic/apyrimidinic) site pocket; other site 405535011600 DNA interaction; other site 405535011601 Metal-binding active site; metal-binding site 405535011602 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 405535011603 DEAD-like helicases superfamily; Region: DEXDc; smart00487 405535011604 ATP binding site [chemical binding]; other site 405535011605 Mg++ binding site [ion binding]; other site 405535011606 motif III; other site 405535011607 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405535011608 nucleotide binding region [chemical binding]; other site 405535011609 ATP-binding site [chemical binding]; other site 405535011610 YqfQ-like protein; Region: YqfQ; pfam14181 405535011611 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 405535011612 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 405535011613 Uncharacterized conserved protein [Function unknown]; Region: COG0327 405535011614 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 405535011615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 405535011616 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 405535011617 Uncharacterized conserved protein [Function unknown]; Region: COG0327 405535011618 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 405535011619 Family of unknown function (DUF633); Region: DUF633; pfam04816 405535011620 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 405535011621 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 405535011622 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 405535011623 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 405535011624 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 405535011625 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535011626 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 405535011627 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405535011628 DNA binding residues [nucleotide binding] 405535011629 DNA primase; Validated; Region: dnaG; PRK05667 405535011630 CHC2 zinc finger; Region: zf-CHC2; pfam01807 405535011631 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 405535011632 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 405535011633 active site 405535011634 metal binding site [ion binding]; metal-binding site 405535011635 interdomain interaction site; other site 405535011636 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 405535011637 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 405535011638 PEP synthetase regulatory protein; Provisional; Region: PRK05339 405535011639 HTH domain; Region: HTH_11; pfam08279 405535011640 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 405535011641 FOG: CBS domain [General function prediction only]; Region: COG0517 405535011642 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 405535011643 Recombination protein O N terminal; Region: RecO_N; pfam11967 405535011644 Recombination protein O C terminal; Region: RecO_C; pfam02565 405535011645 YqzL-like protein; Region: YqzL; pfam14006 405535011646 GTPase Era; Reviewed; Region: era; PRK00089 405535011647 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 405535011648 G1 box; other site 405535011649 GTP/Mg2+ binding site [chemical binding]; other site 405535011650 Switch I region; other site 405535011651 G2 box; other site 405535011652 Switch II region; other site 405535011653 G3 box; other site 405535011654 G4 box; other site 405535011655 G5 box; other site 405535011656 KH domain; Region: KH_2; pfam07650 405535011657 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 405535011658 active site 405535011659 catalytic motif [active] 405535011660 Zn binding site [ion binding]; other site 405535011661 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 405535011662 metal-binding heat shock protein; Provisional; Region: PRK00016 405535011663 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 405535011664 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 405535011665 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405535011666 Zn2+ binding site [ion binding]; other site 405535011667 Mg2+ binding site [ion binding]; other site 405535011668 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 405535011669 PhoH-like protein; Region: PhoH; pfam02562 405535011670 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 405535011671 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 405535011672 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 405535011673 Yqey-like protein; Region: YqeY; pfam09424 405535011674 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 405535011675 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 405535011676 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 405535011677 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405535011678 FeS/SAM binding site; other site 405535011679 TRAM domain; Region: TRAM; cl01282 405535011680 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 405535011681 RNA methyltransferase, RsmE family; Region: TIGR00046 405535011682 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 405535011683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535011684 S-adenosylmethionine binding site [chemical binding]; other site 405535011685 chaperone protein DnaJ; Provisional; Region: PRK14280 405535011686 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 405535011687 HSP70 interaction site [polypeptide binding]; other site 405535011688 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 405535011689 substrate binding site [polypeptide binding]; other site 405535011690 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 405535011691 Zn binding sites [ion binding]; other site 405535011692 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 405535011693 dimer interface [polypeptide binding]; other site 405535011694 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 405535011695 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 405535011696 nucleotide binding site [chemical binding]; other site 405535011697 NEF interaction site [polypeptide binding]; other site 405535011698 SBD interface [polypeptide binding]; other site 405535011699 GrpE; Region: GrpE; pfam01025 405535011700 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 405535011701 dimer interface [polypeptide binding]; other site 405535011702 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 405535011703 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 405535011704 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 405535011705 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 405535011706 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405535011707 FeS/SAM binding site; other site 405535011708 HemN C-terminal domain; Region: HemN_C; pfam06969 405535011709 Predicted transcriptional regulators [Transcription]; Region: COG1733 405535011710 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 405535011711 GTP-binding protein LepA; Provisional; Region: PRK05433 405535011712 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 405535011713 G1 box; other site 405535011714 putative GEF interaction site [polypeptide binding]; other site 405535011715 GTP/Mg2+ binding site [chemical binding]; other site 405535011716 Switch I region; other site 405535011717 G2 box; other site 405535011718 G3 box; other site 405535011719 Switch II region; other site 405535011720 G4 box; other site 405535011721 G5 box; other site 405535011722 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 405535011723 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 405535011724 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 405535011725 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 405535011726 germination protease; Provisional; Region: PRK02858 405535011727 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 405535011728 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 405535011729 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 405535011730 YqzM-like protein; Region: YqzM; pfam14141 405535011731 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 405535011732 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 405535011733 Competence protein; Region: Competence; pfam03772 405535011734 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 405535011735 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405535011736 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 405535011737 catalytic motif [active] 405535011738 Zn binding site [ion binding]; other site 405535011739 SLBB domain; Region: SLBB; pfam10531 405535011740 comEA protein; Region: comE; TIGR01259 405535011741 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 405535011742 late competence protein ComER; Validated; Region: PRK07680 405535011743 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 405535011744 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 405535011745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535011746 S-adenosylmethionine binding site [chemical binding]; other site 405535011747 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 405535011748 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405535011749 Zn2+ binding site [ion binding]; other site 405535011750 Mg2+ binding site [ion binding]; other site 405535011751 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 405535011752 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 405535011753 active site 405535011754 (T/H)XGH motif; other site 405535011755 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 405535011756 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 405535011757 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 405535011758 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 405535011759 shikimate binding site; other site 405535011760 NAD(P) binding site [chemical binding]; other site 405535011761 GTPase YqeH; Provisional; Region: PRK13796 405535011762 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 405535011763 GTP/Mg2+ binding site [chemical binding]; other site 405535011764 G4 box; other site 405535011765 G5 box; other site 405535011766 G1 box; other site 405535011767 Switch I region; other site 405535011768 G2 box; other site 405535011769 G3 box; other site 405535011770 Switch II region; other site 405535011771 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 405535011772 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535011773 active site 405535011774 motif I; other site 405535011775 motif II; other site 405535011776 Sporulation inhibitor A; Region: Sda; pfam08970 405535011777 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 405535011778 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405535011779 DNA binding residues [nucleotide binding] 405535011780 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 405535011781 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 405535011782 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 405535011783 active site 405535011784 Bacterial SH3 domain; Region: SH3_5; pfam08460 405535011785 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 405535011786 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 405535011787 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 405535011788 active site 405535011789 catalytic residues [active] 405535011790 DNA binding site [nucleotide binding] 405535011791 Int/Topo IB signature motif; other site 405535011792 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 405535011793 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 405535011794 Phage tail protein; Region: Sipho_tail; pfam05709 405535011795 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 405535011796 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 405535011797 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 405535011798 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 405535011799 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 405535011800 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 405535011801 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 405535011802 oligomerization interface [polypeptide binding]; other site 405535011803 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 405535011804 Phage capsid family; Region: Phage_capsid; pfam05065 405535011805 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 405535011806 Phage portal protein; Region: Phage_portal; pfam04860 405535011807 Phage-related protein [Function unknown]; Region: COG4695; cl01923 405535011808 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 405535011809 Phage terminase, small subunit; Region: Terminase_4; pfam05119 405535011810 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 405535011811 active site 405535011812 stage II sporulation protein E; Region: spore_II_E; TIGR02865 405535011813 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405535011814 active site 405535011815 DNA binding site [nucleotide binding] 405535011816 Int/Topo IB signature motif; other site 405535011817 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 405535011818 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 405535011819 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 405535011820 cofactor binding site; other site 405535011821 DNA binding site [nucleotide binding] 405535011822 substrate interaction site [chemical binding]; other site 405535011823 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 405535011824 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 405535011825 replicative DNA helicase; Provisional; Region: PRK06749 405535011826 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 405535011827 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 405535011828 Walker A motif; other site 405535011829 ATP binding site [chemical binding]; other site 405535011830 Walker B motif; other site 405535011831 DNA binding loops [nucleotide binding] 405535011832 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 405535011833 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535011834 non-specific DNA binding site [nucleotide binding]; other site 405535011835 salt bridge; other site 405535011836 sequence-specific DNA binding site [nucleotide binding]; other site 405535011837 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535011838 non-specific DNA binding site [nucleotide binding]; other site 405535011839 salt bridge; other site 405535011840 sequence-specific DNA binding site [nucleotide binding]; other site 405535011841 Domain of unknown function (DUF955); Region: DUF955; cl01076 405535011842 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405535011843 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 405535011844 catalytic residues [active] 405535011845 catalytic nucleophile [active] 405535011846 Recombinase; Region: Recombinase; pfam07508 405535011847 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 405535011848 sporulation sigma factor SigK; Reviewed; Region: PRK05803 405535011849 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535011850 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 405535011851 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 405535011852 dimer interface [polypeptide binding]; other site 405535011853 FMN binding site [chemical binding]; other site 405535011854 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 405535011855 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 405535011856 synthetase active site [active] 405535011857 NTP binding site [chemical binding]; other site 405535011858 metal binding site [ion binding]; metal-binding site 405535011859 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 405535011860 dimer interface [polypeptide binding]; other site 405535011861 Alkaline phosphatase homologues; Region: alkPPc; smart00098 405535011862 active site 405535011863 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535011864 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405535011865 Coenzyme A binding pocket [chemical binding]; other site 405535011866 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 405535011867 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405535011868 CHAT domain; Region: CHAT; cl17868 405535011869 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 405535011870 catalytic core [active] 405535011871 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 405535011872 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 405535011873 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 405535011874 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 405535011875 putative active site [active] 405535011876 catalytic triad [active] 405535011877 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 405535011878 putative integrin binding motif; other site 405535011879 PA/protease domain interface [polypeptide binding]; other site 405535011880 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 405535011881 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 405535011882 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 405535011883 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 405535011884 cofactor binding site; other site 405535011885 metal binding site [ion binding]; metal-binding site 405535011886 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 405535011887 aromatic arch; other site 405535011888 DCoH dimer interaction site [polypeptide binding]; other site 405535011889 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 405535011890 DCoH tetramer interaction site [polypeptide binding]; other site 405535011891 substrate binding site [chemical binding]; other site 405535011892 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 405535011893 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 405535011894 putative metal binding site [ion binding]; other site 405535011895 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405535011896 active site 405535011897 metal binding site [ion binding]; metal-binding site 405535011898 Predicted membrane protein [Function unknown]; Region: COG2259 405535011899 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 405535011900 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535011901 non-specific DNA binding site [nucleotide binding]; other site 405535011902 salt bridge; other site 405535011903 sequence-specific DNA binding site [nucleotide binding]; other site 405535011904 Cupin domain; Region: Cupin_2; pfam07883 405535011905 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 405535011906 dimer interaction site [polypeptide binding]; other site 405535011907 substrate-binding tunnel; other site 405535011908 active site 405535011909 catalytic site [active] 405535011910 substrate binding site [chemical binding]; other site 405535011911 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535011912 Coenzyme A binding pocket [chemical binding]; other site 405535011913 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405535011914 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405535011915 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 405535011916 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405535011917 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405535011918 Walker A/P-loop; other site 405535011919 ATP binding site [chemical binding]; other site 405535011920 Q-loop/lid; other site 405535011921 ABC transporter signature motif; other site 405535011922 Walker B; other site 405535011923 D-loop; other site 405535011924 H-loop/switch region; other site 405535011925 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405535011926 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405535011927 ABC-ATPase subunit interface; other site 405535011928 dimer interface [polypeptide binding]; other site 405535011929 putative PBP binding regions; other site 405535011930 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405535011931 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 405535011932 intersubunit interface [polypeptide binding]; other site 405535011933 YrhC-like protein; Region: YrhC; pfam14143 405535011934 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 405535011935 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 405535011936 putative catalytic cysteine [active] 405535011937 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 405535011938 putative active site [active] 405535011939 metal binding site [ion binding]; metal-binding site 405535011940 cystathionine beta-lyase; Provisional; Region: PRK07671 405535011941 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 405535011942 homodimer interface [polypeptide binding]; other site 405535011943 substrate-cofactor binding pocket; other site 405535011944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535011945 catalytic residue [active] 405535011946 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 405535011947 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 405535011948 dimer interface [polypeptide binding]; other site 405535011949 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535011950 catalytic residue [active] 405535011951 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 405535011952 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 405535011953 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405535011954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535011955 S-adenosylmethionine binding site [chemical binding]; other site 405535011956 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 405535011957 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 405535011958 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405535011959 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405535011960 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405535011961 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 405535011962 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 405535011963 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 405535011964 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 405535011965 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 405535011966 ATP-binding site [chemical binding]; other site 405535011967 Sugar specificity; other site 405535011968 Pyrimidine base specificity; other site 405535011969 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 405535011970 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 405535011971 Peptidase family U32; Region: Peptidase_U32; pfam01136 405535011972 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 405535011973 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 405535011974 Peptidase family U32; Region: Peptidase_U32; pfam01136 405535011975 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 405535011976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535011977 S-adenosylmethionine binding site [chemical binding]; other site 405535011978 YceG-like family; Region: YceG; pfam02618 405535011979 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 405535011980 dimerization interface [polypeptide binding]; other site 405535011981 hypothetical protein; Provisional; Region: PRK13678 405535011982 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 405535011983 hypothetical protein; Provisional; Region: PRK05473 405535011984 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 405535011985 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 405535011986 motif 1; other site 405535011987 active site 405535011988 motif 2; other site 405535011989 motif 3; other site 405535011990 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 405535011991 DHHA1 domain; Region: DHHA1; pfam02272 405535011992 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 405535011993 Domain of unknown function DUF20; Region: UPF0118; pfam01594 405535011994 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 405535011995 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 405535011996 AAA domain; Region: AAA_30; pfam13604 405535011997 Family description; Region: UvrD_C_2; pfam13538 405535011998 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535011999 TPR motif; other site 405535012000 TPR repeat; Region: TPR_11; pfam13414 405535012001 binding surface 405535012002 TPR repeat; Region: TPR_11; pfam13414 405535012003 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535012004 binding surface 405535012005 TPR motif; other site 405535012006 TPR repeat; Region: TPR_11; pfam13414 405535012007 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 405535012008 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 405535012009 Ligand Binding Site [chemical binding]; other site 405535012010 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 405535012011 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 405535012012 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405535012013 catalytic residue [active] 405535012014 Predicted transcriptional regulator [Transcription]; Region: COG1959 405535012015 Transcriptional regulator; Region: Rrf2; pfam02082 405535012016 recombination factor protein RarA; Reviewed; Region: PRK13342 405535012017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535012018 Walker A motif; other site 405535012019 ATP binding site [chemical binding]; other site 405535012020 Walker B motif; other site 405535012021 arginine finger; other site 405535012022 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 405535012023 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 405535012024 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 405535012025 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 405535012026 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 405535012027 putative ATP binding site [chemical binding]; other site 405535012028 putative substrate interface [chemical binding]; other site 405535012029 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 405535012030 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 405535012031 dimer interface [polypeptide binding]; other site 405535012032 anticodon binding site; other site 405535012033 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 405535012034 homodimer interface [polypeptide binding]; other site 405535012035 motif 1; other site 405535012036 active site 405535012037 motif 2; other site 405535012038 GAD domain; Region: GAD; pfam02938 405535012039 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 405535012040 motif 3; other site 405535012041 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 405535012042 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 405535012043 dimer interface [polypeptide binding]; other site 405535012044 motif 1; other site 405535012045 active site 405535012046 motif 2; other site 405535012047 motif 3; other site 405535012048 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 405535012049 anticodon binding site; other site 405535012050 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 405535012051 putative active site [active] 405535012052 dimerization interface [polypeptide binding]; other site 405535012053 putative tRNAtyr binding site [nucleotide binding]; other site 405535012054 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 405535012055 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405535012056 Zn2+ binding site [ion binding]; other site 405535012057 Mg2+ binding site [ion binding]; other site 405535012058 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 405535012059 synthetase active site [active] 405535012060 NTP binding site [chemical binding]; other site 405535012061 metal binding site [ion binding]; metal-binding site 405535012062 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 405535012063 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 405535012064 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405535012065 active site 405535012066 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 405535012067 DHH family; Region: DHH; pfam01368 405535012068 DHHA1 domain; Region: DHHA1; pfam02272 405535012069 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 405535012070 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 405535012071 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 405535012072 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 405535012073 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 405535012074 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 405535012075 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 405535012076 Protein export membrane protein; Region: SecD_SecF; pfam02355 405535012077 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 405535012078 stage V sporulation protein B; Region: spore_V_B; TIGR02900 405535012079 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405535012080 Predicted membrane protein [Function unknown]; Region: COG2323 405535012081 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 405535012082 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 405535012083 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 405535012084 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 405535012085 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 405535012086 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 405535012087 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 405535012088 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 405535012089 RuvA N terminal domain; Region: RuvA_N; pfam01330 405535012090 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 405535012091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535012092 Walker A motif; other site 405535012093 ATP binding site [chemical binding]; other site 405535012094 Walker B motif; other site 405535012095 arginine finger; other site 405535012096 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 405535012097 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405535012098 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 405535012099 putative ligand binding residues [chemical binding]; other site 405535012100 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 405535012101 BofC C-terminal domain; Region: BofC_C; pfam08955 405535012102 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405535012103 EamA-like transporter family; Region: EamA; pfam00892 405535012104 EamA-like transporter family; Region: EamA; pfam00892 405535012105 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535012106 dimerization interface [polypeptide binding]; other site 405535012107 putative DNA binding site [nucleotide binding]; other site 405535012108 putative Zn2+ binding site [ion binding]; other site 405535012109 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 405535012110 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405535012111 quinolinate synthetase; Provisional; Region: PRK09375 405535012112 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 405535012113 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 405535012114 dimerization interface [polypeptide binding]; other site 405535012115 active site 405535012116 L-aspartate oxidase; Provisional; Region: PRK08071 405535012117 L-aspartate oxidase; Provisional; Region: PRK06175 405535012118 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 405535012119 cysteine desulfurase; Provisional; Region: PRK02948 405535012120 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 405535012121 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405535012122 catalytic residue [active] 405535012123 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 405535012124 HTH domain; Region: HTH_11; pfam08279 405535012125 3H domain; Region: 3H; pfam02829 405535012126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 405535012127 MOSC domain; Region: MOSC; pfam03473 405535012128 3-alpha domain; Region: 3-alpha; pfam03475 405535012129 prephenate dehydratase; Provisional; Region: PRK11898 405535012130 Prephenate dehydratase; Region: PDT; pfam00800 405535012131 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 405535012132 putative L-Phe binding site [chemical binding]; other site 405535012133 FtsX-like permease family; Region: FtsX; pfam02687 405535012134 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405535012135 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405535012136 FtsX-like permease family; Region: FtsX; pfam02687 405535012137 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405535012138 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405535012139 Walker A/P-loop; other site 405535012140 ATP binding site [chemical binding]; other site 405535012141 Q-loop/lid; other site 405535012142 ABC transporter signature motif; other site 405535012143 Walker B; other site 405535012144 D-loop; other site 405535012145 H-loop/switch region; other site 405535012146 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535012147 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 405535012148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535012149 ATP binding site [chemical binding]; other site 405535012150 Mg2+ binding site [ion binding]; other site 405535012151 G-X-G motif; other site 405535012152 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535012153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535012154 active site 405535012155 phosphorylation site [posttranslational modification] 405535012156 intermolecular recognition site; other site 405535012157 dimerization interface [polypeptide binding]; other site 405535012158 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535012159 DNA binding site [nucleotide binding] 405535012160 GTPase CgtA; Reviewed; Region: obgE; PRK12297 405535012161 GTP1/OBG; Region: GTP1_OBG; pfam01018 405535012162 Obg GTPase; Region: Obg; cd01898 405535012163 G1 box; other site 405535012164 GTP/Mg2+ binding site [chemical binding]; other site 405535012165 Switch I region; other site 405535012166 G2 box; other site 405535012167 G3 box; other site 405535012168 Switch II region; other site 405535012169 G4 box; other site 405535012170 G5 box; other site 405535012171 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 405535012172 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 405535012173 hypothetical protein; Provisional; Region: PRK14553 405535012174 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 405535012175 Ribosomal protein L21 leader 405535012176 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 405535012177 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 405535012178 homodimer interface [polypeptide binding]; other site 405535012179 oligonucleotide binding site [chemical binding]; other site 405535012180 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 405535012181 Peptidase family M50; Region: Peptidase_M50; pfam02163 405535012182 active site 405535012183 putative substrate binding region [chemical binding]; other site 405535012184 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405535012185 Peptidase family M23; Region: Peptidase_M23; pfam01551 405535012186 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 405535012187 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 405535012188 Switch I; other site 405535012189 Switch II; other site 405535012190 septum formation inhibitor; Reviewed; Region: minC; PRK00513 405535012191 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 405535012192 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 405535012193 rod shape-determining protein MreC; Provisional; Region: PRK13922 405535012194 rod shape-determining protein MreC; Region: MreC; pfam04085 405535012195 rod shape-determining protein MreB; Provisional; Region: PRK13927 405535012196 MreB and similar proteins; Region: MreB_like; cd10225 405535012197 nucleotide binding site [chemical binding]; other site 405535012198 Mg binding site [ion binding]; other site 405535012199 putative protofilament interaction site [polypeptide binding]; other site 405535012200 RodZ interaction site [polypeptide binding]; other site 405535012201 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405535012202 metal-binding site [ion binding] 405535012203 mercuric reductase; Region: MerA; TIGR02053 405535012204 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405535012205 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405535012206 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405535012207 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405535012208 metal-binding site [ion binding] 405535012209 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 405535012210 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 405535012211 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 405535012212 DNA binding residues [nucleotide binding] 405535012213 dimer interface [polypeptide binding]; other site 405535012214 mercury binding site [ion binding]; other site 405535012215 seryl-tRNA synthetase; Provisional; Region: PRK05431 405535012216 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 405535012217 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 405535012218 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405535012219 active site 405535012220 DNA binding site [nucleotide binding] 405535012221 Int/Topo IB signature motif; other site 405535012222 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 405535012223 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 405535012224 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 405535012225 Int/Topo IB signature motif; other site 405535012226 hypothetical protein; Reviewed; Region: PRK00024 405535012227 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 405535012228 MPN+ (JAMM) motif; other site 405535012229 Zinc-binding site [ion binding]; other site 405535012230 Maf-like protein; Region: Maf; pfam02545 405535012231 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 405535012232 active site 405535012233 dimer interface [polypeptide binding]; other site 405535012234 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 405535012235 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405535012236 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405535012237 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 405535012238 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 405535012239 active site 405535012240 HIGH motif; other site 405535012241 nucleotide binding site [chemical binding]; other site 405535012242 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 405535012243 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 405535012244 active site 405535012245 KMSKS motif; other site 405535012246 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 405535012247 tRNA binding surface [nucleotide binding]; other site 405535012248 anticodon binding site; other site 405535012249 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 405535012250 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 405535012251 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 405535012252 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405535012253 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 405535012254 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405535012255 inhibitor-cofactor binding pocket; inhibition site 405535012256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535012257 catalytic residue [active] 405535012258 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 405535012259 dimer interface [polypeptide binding]; other site 405535012260 active site 405535012261 Schiff base residues; other site 405535012262 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 405535012263 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 405535012264 active site 405535012265 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 405535012266 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 405535012267 domain interfaces; other site 405535012268 active site 405535012269 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 405535012270 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 405535012271 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 405535012272 tRNA; other site 405535012273 putative tRNA binding site [nucleotide binding]; other site 405535012274 putative NADP binding site [chemical binding]; other site 405535012275 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 405535012276 Transcriptional regulators [Transcription]; Region: MarR; COG1846 405535012277 MarR family; Region: MarR; pfam01047 405535012278 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 405535012279 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 405535012280 G1 box; other site 405535012281 GTP/Mg2+ binding site [chemical binding]; other site 405535012282 Switch I region; other site 405535012283 G2 box; other site 405535012284 G3 box; other site 405535012285 Switch II region; other site 405535012286 G4 box; other site 405535012287 G5 box; other site 405535012288 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 405535012289 Found in ATP-dependent protease La (LON); Region: LON; smart00464 405535012290 Found in ATP-dependent protease La (LON); Region: LON; smart00464 405535012291 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535012292 Walker A motif; other site 405535012293 ATP binding site [chemical binding]; other site 405535012294 Walker B motif; other site 405535012295 arginine finger; other site 405535012296 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 405535012297 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 405535012298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535012299 Walker A motif; other site 405535012300 ATP binding site [chemical binding]; other site 405535012301 Walker B motif; other site 405535012302 arginine finger; other site 405535012303 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 405535012304 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 405535012305 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 405535012306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535012307 Walker A motif; other site 405535012308 ATP binding site [chemical binding]; other site 405535012309 Walker B motif; other site 405535012310 arginine finger; other site 405535012311 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 405535012312 trigger factor; Provisional; Region: tig; PRK01490 405535012313 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 405535012314 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 405535012315 Protein of unknown function (DUF3257); Region: DUF3257; pfam11645 405535012316 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 405535012317 pentamer interface [polypeptide binding]; other site 405535012318 dodecaamer interface [polypeptide binding]; other site 405535012319 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 405535012320 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 405535012321 active site 405535012322 metal binding site [ion binding]; metal-binding site 405535012323 homotetramer interface [polypeptide binding]; other site 405535012324 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 405535012325 active site 405535012326 dimerization interface [polypeptide binding]; other site 405535012327 ribonuclease PH; Reviewed; Region: rph; PRK00173 405535012328 Ribonuclease PH; Region: RNase_PH_bact; cd11362 405535012329 hexamer interface [polypeptide binding]; other site 405535012330 active site 405535012331 Sporulation and spore germination; Region: Germane; pfam10646 405535012332 Spore germination protein [General function prediction only]; Region: COG5401 405535012333 Sporulation and spore germination; Region: Germane; pfam10646 405535012334 glutamate racemase; Provisional; Region: PRK00865 405535012335 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 405535012336 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 405535012337 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 405535012338 potential catalytic triad [active] 405535012339 conserved cys residue [active] 405535012340 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535012341 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535012342 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 405535012343 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 405535012344 potential catalytic triad [active] 405535012345 conserved cys residue [active] 405535012346 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405535012347 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 405535012348 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405535012349 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 405535012350 catalytic residues [active] 405535012351 catalytic nucleophile [active] 405535012352 Recombinase; Region: Recombinase; pfam07508 405535012353 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 405535012354 AAA domain; Region: AAA_23; pfam13476 405535012355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535012356 Walker A/P-loop; other site 405535012357 ATP binding site [chemical binding]; other site 405535012358 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405535012359 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 405535012360 catalytic residues [active] 405535012361 catalytic nucleophile [active] 405535012362 Recombinase; Region: Recombinase; pfam07508 405535012363 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405535012364 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 405535012365 catalytic residues [active] 405535012366 Recombinase; Region: Recombinase; pfam07508 405535012367 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405535012368 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535012369 non-specific DNA binding site [nucleotide binding]; other site 405535012370 salt bridge; other site 405535012371 sequence-specific DNA binding site [nucleotide binding]; other site 405535012372 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 405535012373 DHH family; Region: DHH; pfam01368 405535012374 DHHA1 domain; Region: DHHA1; pfam02272 405535012375 Helix-turn-helix domain; Region: HTH_17; pfam12728 405535012376 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405535012377 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535012378 non-specific DNA binding site [nucleotide binding]; other site 405535012379 salt bridge; other site 405535012380 sequence-specific DNA binding site [nucleotide binding]; other site 405535012381 PemK-like protein; Region: PemK; pfam02452 405535012382 Helix-turn-helix domain; Region: HTH_19; pfam12844 405535012383 non-specific DNA binding site [nucleotide binding]; other site 405535012384 salt bridge; other site 405535012385 sequence-specific DNA binding site [nucleotide binding]; other site 405535012386 Domain of unknown function (DUF955); Region: DUF955; pfam06114 405535012387 putative uracil/xanthine transporter; Provisional; Region: PRK11412 405535012388 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405535012389 EamA-like transporter family; Region: EamA; pfam00892 405535012390 EamA-like transporter family; Region: EamA; pfam00892 405535012391 putative deaminase; Validated; Region: PRK06846 405535012392 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 405535012393 active site 405535012394 putative deaminase; Validated; Region: PRK06846 405535012395 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 405535012396 active site 405535012397 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 405535012398 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 405535012399 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405535012400 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 405535012401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535012402 dimer interface [polypeptide binding]; other site 405535012403 conserved gate region; other site 405535012404 ABC-ATPase subunit interface; other site 405535012405 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405535012406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535012407 dimer interface [polypeptide binding]; other site 405535012408 conserved gate region; other site 405535012409 putative PBP binding loops; other site 405535012410 ABC-ATPase subunit interface; other site 405535012411 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 405535012412 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405535012413 Walker A/P-loop; other site 405535012414 ATP binding site [chemical binding]; other site 405535012415 Q-loop/lid; other site 405535012416 ABC transporter signature motif; other site 405535012417 Walker B; other site 405535012418 D-loop; other site 405535012419 H-loop/switch region; other site 405535012420 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 405535012421 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 405535012422 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405535012423 Walker A/P-loop; other site 405535012424 ATP binding site [chemical binding]; other site 405535012425 Q-loop/lid; other site 405535012426 ABC transporter signature motif; other site 405535012427 Walker B; other site 405535012428 D-loop; other site 405535012429 H-loop/switch region; other site 405535012430 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 405535012431 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 405535012432 Histidine kinase; Region: His_kinase; pfam06580 405535012433 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 405535012434 ATP binding site [chemical binding]; other site 405535012435 Mg2+ binding site [ion binding]; other site 405535012436 G-X-G motif; other site 405535012437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535012438 Response regulator receiver domain; Region: Response_reg; pfam00072 405535012439 active site 405535012440 phosphorylation site [posttranslational modification] 405535012441 intermolecular recognition site; other site 405535012442 dimerization interface [polypeptide binding]; other site 405535012443 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405535012444 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405535012445 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405535012446 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 405535012447 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 405535012448 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 405535012449 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535012450 non-specific DNA binding site [nucleotide binding]; other site 405535012451 salt bridge; other site 405535012452 sequence-specific DNA binding site [nucleotide binding]; other site 405535012453 Cupin domain; Region: Cupin_2; pfam07883 405535012454 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 405535012455 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 405535012456 amphipathic channel; other site 405535012457 Asn-Pro-Ala signature motifs; other site 405535012458 Predicted transcriptional regulator [Transcription]; Region: COG1959 405535012459 Transcriptional regulator; Region: Rrf2; pfam02082 405535012460 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 405535012461 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 405535012462 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535012463 Walker A/P-loop; other site 405535012464 ATP binding site [chemical binding]; other site 405535012465 Q-loop/lid; other site 405535012466 ABC transporter signature motif; other site 405535012467 Walker B; other site 405535012468 D-loop; other site 405535012469 H-loop/switch region; other site 405535012470 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 405535012471 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 405535012472 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 405535012473 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 405535012474 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 405535012475 ligand binding site [chemical binding]; other site 405535012476 flagellar motor protein MotA; Validated; Region: PRK08124 405535012477 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 405535012478 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 405535012479 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 405535012480 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 405535012481 active site 405535012482 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 405535012483 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 405535012484 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 405535012485 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 405535012486 L-aspartate oxidase; Provisional; Region: PRK06175 405535012487 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 405535012488 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 405535012489 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 405535012490 putative Iron-sulfur protein interface [polypeptide binding]; other site 405535012491 proximal heme binding site [chemical binding]; other site 405535012492 distal heme binding site [chemical binding]; other site 405535012493 putative dimer interface [polypeptide binding]; other site 405535012494 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 405535012495 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 405535012496 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 405535012497 GIY-YIG motif/motif A; other site 405535012498 active site 405535012499 catalytic site [active] 405535012500 putative DNA binding site [nucleotide binding]; other site 405535012501 metal binding site [ion binding]; metal-binding site 405535012502 UvrB/uvrC motif; Region: UVR; pfam02151 405535012503 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 405535012504 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405535012505 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 405535012506 catalytic residues [active] 405535012507 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 405535012508 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 405535012509 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 405535012510 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 405535012511 Ligand binding site [chemical binding]; other site 405535012512 Electron transfer flavoprotein domain; Region: ETF; pfam01012 405535012513 enoyl-CoA hydratase; Provisional; Region: PRK07658 405535012514 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405535012515 substrate binding site [chemical binding]; other site 405535012516 oxyanion hole (OAH) forming residues; other site 405535012517 trimer interface [polypeptide binding]; other site 405535012518 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 405535012519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535012520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535012521 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 405535012522 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 405535012523 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 405535012524 acyl-activating enzyme (AAE) consensus motif; other site 405535012525 putative AMP binding site [chemical binding]; other site 405535012526 putative active site [active] 405535012527 putative CoA binding site [chemical binding]; other site 405535012528 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 405535012529 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 405535012530 siderophore binding site; other site 405535012531 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405535012532 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405535012533 ABC-ATPase subunit interface; other site 405535012534 dimer interface [polypeptide binding]; other site 405535012535 putative PBP binding regions; other site 405535012536 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405535012537 ABC-ATPase subunit interface; other site 405535012538 dimer interface [polypeptide binding]; other site 405535012539 putative PBP binding regions; other site 405535012540 DinB family; Region: DinB; pfam05163 405535012541 DinB superfamily; Region: DinB_2; pfam12867 405535012542 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 405535012543 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 405535012544 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 405535012545 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405535012546 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405535012547 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 405535012548 Walker A/P-loop; other site 405535012549 ATP binding site [chemical binding]; other site 405535012550 Q-loop/lid; other site 405535012551 ABC transporter signature motif; other site 405535012552 Walker B; other site 405535012553 D-loop; other site 405535012554 H-loop/switch region; other site 405535012555 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535012556 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535012557 dimer interface [polypeptide binding]; other site 405535012558 phosphorylation site [posttranslational modification] 405535012559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535012560 ATP binding site [chemical binding]; other site 405535012561 Mg2+ binding site [ion binding]; other site 405535012562 G-X-G motif; other site 405535012563 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535012564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535012565 active site 405535012566 phosphorylation site [posttranslational modification] 405535012567 intermolecular recognition site; other site 405535012568 dimerization interface [polypeptide binding]; other site 405535012569 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535012570 DNA binding site [nucleotide binding] 405535012571 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 405535012572 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 405535012573 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 405535012574 putative RNA binding site [nucleotide binding]; other site 405535012575 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 405535012576 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 405535012577 TrkA-N domain; Region: TrkA_N; pfam02254 405535012578 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 405535012579 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 405535012580 active site 405535012581 catalytic site [active] 405535012582 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405535012583 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405535012584 Walker A/P-loop; other site 405535012585 ATP binding site [chemical binding]; other site 405535012586 Q-loop/lid; other site 405535012587 ABC transporter signature motif; other site 405535012588 Walker B; other site 405535012589 D-loop; other site 405535012590 H-loop/switch region; other site 405535012591 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405535012592 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405535012593 ABC-ATPase subunit interface; other site 405535012594 dimer interface [polypeptide binding]; other site 405535012595 putative PBP binding regions; other site 405535012596 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 405535012597 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 405535012598 intersubunit interface [polypeptide binding]; other site 405535012599 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405535012600 heme-binding site [chemical binding]; other site 405535012601 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405535012602 heme-binding site [chemical binding]; other site 405535012603 Repeat of unknown function (DUF1388); Region: DUF1388; pfam07142 405535012604 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405535012605 heme-binding site [chemical binding]; other site 405535012606 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405535012607 heme-binding site [chemical binding]; other site 405535012608 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405535012609 heme-binding site [chemical binding]; other site 405535012610 heme uptake protein IsdC; Region: IsdC; TIGR03656 405535012611 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405535012612 heme-binding site [chemical binding]; other site 405535012613 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 405535012614 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405535012615 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 405535012616 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405535012617 RNA binding surface [nucleotide binding]; other site 405535012618 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 405535012619 probable active site [active] 405535012620 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 405535012621 MutS domain III; Region: MutS_III; pfam05192 405535012622 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 405535012623 Walker A/P-loop; other site 405535012624 ATP binding site [chemical binding]; other site 405535012625 Q-loop/lid; other site 405535012626 ABC transporter signature motif; other site 405535012627 Walker B; other site 405535012628 D-loop; other site 405535012629 H-loop/switch region; other site 405535012630 Smr domain; Region: Smr; pfam01713 405535012631 hypothetical protein; Provisional; Region: PRK08609 405535012632 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 405535012633 active site 405535012634 primer binding site [nucleotide binding]; other site 405535012635 NTP binding site [chemical binding]; other site 405535012636 metal binding triad [ion binding]; metal-binding site 405535012637 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 405535012638 active site 405535012639 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 405535012640 Colicin V production protein; Region: Colicin_V; pfam02674 405535012641 cell division protein ZapA; Provisional; Region: PRK14126 405535012642 potential frameshift: common BLAST hit: gi|49187446|ref|YP_030698.1| ribonuclease HIII 405535012643 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 405535012644 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 405535012645 RNA/DNA hybrid binding site [nucleotide binding]; other site 405535012646 active site 405535012647 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 405535012648 RNA/DNA hybrid binding site [nucleotide binding]; other site 405535012649 active site 405535012650 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 405535012651 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 405535012652 putative dimer interface [polypeptide binding]; other site 405535012653 putative anticodon binding site; other site 405535012654 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 405535012655 homodimer interface [polypeptide binding]; other site 405535012656 motif 1; other site 405535012657 motif 2; other site 405535012658 active site 405535012659 motif 3; other site 405535012660 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 405535012661 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 405535012662 putative tRNA-binding site [nucleotide binding]; other site 405535012663 B3/4 domain; Region: B3_4; pfam03483 405535012664 tRNA synthetase B5 domain; Region: B5; smart00874 405535012665 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 405535012666 dimer interface [polypeptide binding]; other site 405535012667 motif 1; other site 405535012668 motif 3; other site 405535012669 motif 2; other site 405535012670 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 405535012671 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 405535012672 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 405535012673 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 405535012674 dimer interface [polypeptide binding]; other site 405535012675 motif 1; other site 405535012676 active site 405535012677 motif 2; other site 405535012678 motif 3; other site 405535012679 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 405535012680 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 405535012681 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 405535012682 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 405535012683 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405535012684 Zn2+ binding site [ion binding]; other site 405535012685 Mg2+ binding site [ion binding]; other site 405535012686 CAAX protease self-immunity; Region: Abi; pfam02517 405535012687 CAAX protease self-immunity; Region: Abi; pfam02517 405535012688 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 405535012689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535012690 putative substrate translocation pore; other site 405535012691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535012692 HlyD family secretion protein; Region: HlyD_3; pfam13437 405535012693 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535012694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535012695 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 405535012696 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 405535012697 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 405535012698 oligomer interface [polypeptide binding]; other site 405535012699 active site 405535012700 metal binding site [ion binding]; metal-binding site 405535012701 dUTPase; Region: dUTPase_2; pfam08761 405535012702 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 405535012703 active site 405535012704 homodimer interface [polypeptide binding]; other site 405535012705 metal binding site [ion binding]; metal-binding site 405535012706 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 405535012707 23S rRNA binding site [nucleotide binding]; other site 405535012708 L21 binding site [polypeptide binding]; other site 405535012709 L13 binding site [polypeptide binding]; other site 405535012710 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 405535012711 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 405535012712 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 405535012713 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 405535012714 Ribosomal protein L20 leader 405535012715 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 405535012716 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 405535012717 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 405535012718 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 405535012719 active site 405535012720 dimer interface [polypeptide binding]; other site 405535012721 motif 1; other site 405535012722 motif 2; other site 405535012723 motif 3; other site 405535012724 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 405535012725 anticodon binding site; other site 405535012726 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 405535012727 primosomal protein DnaI; Reviewed; Region: PRK08939 405535012728 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 405535012729 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535012730 Walker A motif; other site 405535012731 ATP binding site [chemical binding]; other site 405535012732 Walker B motif; other site 405535012733 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 405535012734 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 405535012735 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 405535012736 ATP cone domain; Region: ATP-cone; pfam03477 405535012737 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 405535012738 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 405535012739 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 405535012740 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 405535012741 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 405535012742 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 405535012743 CoA-binding site [chemical binding]; other site 405535012744 ATP-binding [chemical binding]; other site 405535012745 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 405535012746 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 405535012747 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 405535012748 DNA binding site [nucleotide binding] 405535012749 catalytic residue [active] 405535012750 H2TH interface [polypeptide binding]; other site 405535012751 putative catalytic residues [active] 405535012752 turnover-facilitating residue; other site 405535012753 intercalation triad [nucleotide binding]; other site 405535012754 8OG recognition residue [nucleotide binding]; other site 405535012755 putative reading head residues; other site 405535012756 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 405535012757 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 405535012758 DNA polymerase I; Provisional; Region: PRK05755 405535012759 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 405535012760 active site 405535012761 metal binding site 1 [ion binding]; metal-binding site 405535012762 putative 5' ssDNA interaction site; other site 405535012763 metal binding site 3; metal-binding site 405535012764 metal binding site 2 [ion binding]; metal-binding site 405535012765 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 405535012766 putative DNA binding site [nucleotide binding]; other site 405535012767 putative metal binding site [ion binding]; other site 405535012768 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 405535012769 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 405535012770 active site 405535012771 DNA binding site [nucleotide binding] 405535012772 catalytic site [active] 405535012773 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535012774 dimerization interface [polypeptide binding]; other site 405535012775 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 405535012776 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405535012777 putative active site [active] 405535012778 heme pocket [chemical binding]; other site 405535012779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535012780 dimer interface [polypeptide binding]; other site 405535012781 phosphorylation site [posttranslational modification] 405535012782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535012783 ATP binding site [chemical binding]; other site 405535012784 Mg2+ binding site [ion binding]; other site 405535012785 G-X-G motif; other site 405535012786 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535012787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535012788 active site 405535012789 phosphorylation site [posttranslational modification] 405535012790 intermolecular recognition site; other site 405535012791 dimerization interface [polypeptide binding]; other site 405535012792 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535012793 DNA binding site [nucleotide binding] 405535012794 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 405535012795 active site 2 [active] 405535012796 active site 1 [active] 405535012797 malate dehydrogenase; Reviewed; Region: PRK06223 405535012798 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 405535012799 NAD(P) binding site [chemical binding]; other site 405535012800 dimer interface [polypeptide binding]; other site 405535012801 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405535012802 substrate binding site [chemical binding]; other site 405535012803 isocitrate dehydrogenase; Reviewed; Region: PRK07006 405535012804 isocitrate dehydrogenase; Validated; Region: PRK07362 405535012805 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 405535012806 dimer interface [polypeptide binding]; other site 405535012807 Citrate synthase; Region: Citrate_synt; pfam00285 405535012808 active site 405535012809 citrylCoA binding site [chemical binding]; other site 405535012810 oxalacetate/citrate binding site [chemical binding]; other site 405535012811 coenzyme A binding site [chemical binding]; other site 405535012812 catalytic triad [active] 405535012813 Protein of unknown function (DUF441); Region: DUF441; pfam04284 405535012814 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 405535012815 Domain of unknown function DUF20; Region: UPF0118; pfam01594 405535012816 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 405535012817 pyruvate kinase; Provisional; Region: PRK06354 405535012818 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 405535012819 domain interfaces; other site 405535012820 active site 405535012821 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 405535012822 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 405535012823 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 405535012824 active site 405535012825 ADP/pyrophosphate binding site [chemical binding]; other site 405535012826 dimerization interface [polypeptide binding]; other site 405535012827 allosteric effector site; other site 405535012828 fructose-1,6-bisphosphate binding site; other site 405535012829 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 405535012830 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 405535012831 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 405535012832 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 405535012833 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 405535012834 Transcriptional regulators [Transcription]; Region: FadR; COG2186 405535012835 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535012836 DNA-binding site [nucleotide binding]; DNA binding site 405535012837 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 405535012838 Malic enzyme, N-terminal domain; Region: malic; pfam00390 405535012839 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 405535012840 putative NAD(P) binding site [chemical binding]; other site 405535012841 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 405535012842 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 405535012843 active site 405535012844 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 405535012845 generic binding surface II; other site 405535012846 generic binding surface I; other site 405535012847 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 405535012848 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 405535012849 DHH family; Region: DHH; pfam01368 405535012850 DHHA1 domain; Region: DHHA1; pfam02272 405535012851 YtpI-like protein; Region: YtpI; pfam14007 405535012852 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 405535012853 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 405535012854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535012855 DNA-binding site [nucleotide binding]; DNA binding site 405535012856 DRTGG domain; Region: DRTGG; pfam07085 405535012857 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 405535012858 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 405535012859 active site 2 [active] 405535012860 active site 1 [active] 405535012861 metal-dependent hydrolase; Provisional; Region: PRK00685 405535012862 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 405535012863 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 405535012864 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 405535012865 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 405535012866 active site 405535012867 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 405535012868 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 405535012869 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 405535012870 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 405535012871 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535012872 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405535012873 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535012874 Coenzyme A binding pocket [chemical binding]; other site 405535012875 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 405535012876 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 405535012877 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 405535012878 hexamer interface [polypeptide binding]; other site 405535012879 ligand binding site [chemical binding]; other site 405535012880 putative active site [active] 405535012881 NAD(P) binding site [chemical binding]; other site 405535012882 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 405535012883 classical (c) SDRs; Region: SDR_c; cd05233 405535012884 NAD(P) binding site [chemical binding]; other site 405535012885 active site 405535012886 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 405535012887 Ligand Binding Site [chemical binding]; other site 405535012888 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 405535012889 argininosuccinate lyase; Provisional; Region: PRK00855 405535012890 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 405535012891 active sites [active] 405535012892 tetramer interface [polypeptide binding]; other site 405535012893 argininosuccinate synthase; Provisional; Region: PRK13820 405535012894 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 405535012895 ANP binding site [chemical binding]; other site 405535012896 Substrate Binding Site II [chemical binding]; other site 405535012897 Substrate Binding Site I [chemical binding]; other site 405535012898 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405535012899 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405535012900 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405535012901 EcsC protein family; Region: EcsC; pfam12787 405535012902 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 405535012903 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 405535012904 nudix motif; other site 405535012905 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 405535012906 propionate/acetate kinase; Provisional; Region: PRK12379 405535012907 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 405535012908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535012909 S-adenosylmethionine binding site [chemical binding]; other site 405535012910 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 405535012911 dimer interface [polypeptide binding]; other site 405535012912 catalytic triad [active] 405535012913 peroxidatic and resolving cysteines [active] 405535012914 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 405535012915 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 405535012916 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 405535012917 ATP-NAD kinase; Region: NAD_kinase; pfam01513 405535012918 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 405535012919 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 405535012920 active site 405535012921 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405535012922 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 405535012923 dimer interface [polypeptide binding]; other site 405535012924 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 405535012925 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 405535012926 active site 405535012927 acyl-activating enzyme (AAE) consensus motif; other site 405535012928 putative CoA binding site [chemical binding]; other site 405535012929 AMP binding site [chemical binding]; other site 405535012930 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405535012931 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 405535012932 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 405535012933 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 405535012934 Ligand Binding Site [chemical binding]; other site 405535012935 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 405535012936 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 405535012937 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405535012938 catalytic residue [active] 405535012939 septation ring formation regulator EzrA; Provisional; Region: PRK04778 405535012940 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405535012941 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405535012942 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405535012943 dimerization interface [polypeptide binding]; other site 405535012944 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405535012945 EamA-like transporter family; Region: EamA; pfam00892 405535012946 EamA-like transporter family; Region: EamA; pfam00892 405535012947 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535012948 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535012949 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 405535012950 GAF domain; Region: GAF_2; pfam13185 405535012951 methionine gamma-lyase; Provisional; Region: PRK06767 405535012952 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 405535012953 homodimer interface [polypeptide binding]; other site 405535012954 substrate-cofactor binding pocket; other site 405535012955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535012956 catalytic residue [active] 405535012957 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 405535012958 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 405535012959 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405535012960 RNA binding surface [nucleotide binding]; other site 405535012961 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 405535012962 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 405535012963 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 405535012964 active site 405535012965 HIGH motif; other site 405535012966 dimer interface [polypeptide binding]; other site 405535012967 KMSKS motif; other site 405535012968 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405535012969 RNA binding surface [nucleotide binding]; other site 405535012970 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 405535012971 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535012972 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405535012973 DNA binding residues [nucleotide binding] 405535012974 acetyl-CoA synthetase; Provisional; Region: PRK04319 405535012975 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 405535012976 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 405535012977 active site 405535012978 acyl-activating enzyme (AAE) consensus motif; other site 405535012979 putative CoA binding site [chemical binding]; other site 405535012980 AMP binding site [chemical binding]; other site 405535012981 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405535012982 Coenzyme A binding pocket [chemical binding]; other site 405535012983 FOG: CBS domain [General function prediction only]; Region: COG0517 405535012984 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 405535012985 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 405535012986 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 405535012987 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 405535012988 active site 405535012989 Zn binding site [ion binding]; other site 405535012990 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405535012991 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535012992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535012993 active site 405535012994 phosphorylation site [posttranslational modification] 405535012995 intermolecular recognition site; other site 405535012996 dimerization interface [polypeptide binding]; other site 405535012997 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535012998 DNA binding site [nucleotide binding] 405535012999 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535013000 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535013001 dimerization interface [polypeptide binding]; other site 405535013002 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535013003 dimer interface [polypeptide binding]; other site 405535013004 phosphorylation site [posttranslational modification] 405535013005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535013006 ATP binding site [chemical binding]; other site 405535013007 Mg2+ binding site [ion binding]; other site 405535013008 G-X-G motif; other site 405535013009 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 405535013010 Ankyrin repeat; Region: Ank; pfam00023 405535013011 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 405535013012 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 405535013013 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 405535013014 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 405535013015 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405535013016 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 405535013017 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 405535013018 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 405535013019 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 405535013020 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 405535013021 catabolite control protein A; Region: ccpA; TIGR01481 405535013022 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405535013023 DNA binding site [nucleotide binding] 405535013024 domain linker motif; other site 405535013025 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 405535013026 dimerization interface [polypeptide binding]; other site 405535013027 effector binding site; other site 405535013028 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 405535013029 putative dimer interface [polypeptide binding]; other site 405535013030 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 405535013031 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 405535013032 putative dimer interface [polypeptide binding]; other site 405535013033 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 405535013034 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 405535013035 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 405535013036 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 405535013037 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 405535013038 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405535013039 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405535013040 Coenzyme A binding pocket [chemical binding]; other site 405535013041 Predicted transcriptional regulators [Transcription]; Region: COG1695 405535013042 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405535013043 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 405535013044 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 405535013045 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405535013046 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405535013047 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 405535013048 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 405535013049 active site 405535013050 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 405535013051 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 405535013052 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 405535013053 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 405535013054 putative tRNA-binding site [nucleotide binding]; other site 405535013055 hypothetical protein; Provisional; Region: PRK13668 405535013056 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405535013057 catalytic residues [active] 405535013058 NTPase; Reviewed; Region: PRK03114 405535013059 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 405535013060 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 405535013061 oligomer interface [polypeptide binding]; other site 405535013062 active site 405535013063 metal binding site [ion binding]; metal-binding site 405535013064 Predicted small secreted protein [Function unknown]; Region: COG5584 405535013065 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405535013066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535013067 S-adenosylmethionine binding site [chemical binding]; other site 405535013068 YtzH-like protein; Region: YtzH; pfam14165 405535013069 Phosphotransferase enzyme family; Region: APH; pfam01636 405535013070 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 405535013071 active site 405535013072 substrate binding site [chemical binding]; other site 405535013073 ATP binding site [chemical binding]; other site 405535013074 pullulanase, type I; Region: pulA_typeI; TIGR02104 405535013075 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 405535013076 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 405535013077 Ca binding site [ion binding]; other site 405535013078 active site 405535013079 catalytic site [active] 405535013080 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 405535013081 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 405535013082 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 405535013083 dipeptidase PepV; Reviewed; Region: PRK07318 405535013084 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 405535013085 active site 405535013086 metal binding site [ion binding]; metal-binding site 405535013087 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 405535013088 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 405535013089 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405535013090 RNA binding surface [nucleotide binding]; other site 405535013091 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 405535013092 active site 405535013093 uracil binding [chemical binding]; other site 405535013094 stage V sporulation protein B; Region: spore_V_B; TIGR02900 405535013095 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405535013096 HI0933-like protein; Region: HI0933_like; pfam03486 405535013097 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405535013098 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 405535013099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535013100 putative substrate translocation pore; other site 405535013101 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535013102 dimerization interface [polypeptide binding]; other site 405535013103 putative DNA binding site [nucleotide binding]; other site 405535013104 putative Zn2+ binding site [ion binding]; other site 405535013105 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 405535013106 putative hydrophobic ligand binding site [chemical binding]; other site 405535013107 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 405535013108 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 405535013109 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 405535013110 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 405535013111 glucose-1-dehydrogenase; Provisional; Region: PRK08936 405535013112 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 405535013113 NAD binding site [chemical binding]; other site 405535013114 homodimer interface [polypeptide binding]; other site 405535013115 active site 405535013116 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 405535013117 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 405535013118 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 405535013119 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 405535013120 MoaE interaction surface [polypeptide binding]; other site 405535013121 MoeB interaction surface [polypeptide binding]; other site 405535013122 thiocarboxylated glycine; other site 405535013123 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 405535013124 MoaE homodimer interface [polypeptide binding]; other site 405535013125 MoaD interaction [polypeptide binding]; other site 405535013126 active site residues [active] 405535013127 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 405535013128 Walker A motif; other site 405535013129 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 405535013130 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 405535013131 dimer interface [polypeptide binding]; other site 405535013132 putative functional site; other site 405535013133 putative MPT binding site; other site 405535013134 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 405535013135 trimer interface [polypeptide binding]; other site 405535013136 dimer interface [polypeptide binding]; other site 405535013137 putative active site [active] 405535013138 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 405535013139 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 405535013140 ATP binding site [chemical binding]; other site 405535013141 substrate interface [chemical binding]; other site 405535013142 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 405535013143 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405535013144 FeS/SAM binding site; other site 405535013145 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 405535013146 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 405535013147 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405535013148 active site residue [active] 405535013149 homoserine O-acetyltransferase; Provisional; Region: PRK06765 405535013150 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 405535013151 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405535013152 Spore germination protein; Region: Spore_permease; pfam03845 405535013153 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405535013154 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405535013155 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 405535013156 putative nucleotide binding site [chemical binding]; other site 405535013157 putative metal binding site [ion binding]; other site 405535013158 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 405535013159 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 405535013160 HIGH motif; other site 405535013161 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 405535013162 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 405535013163 active site 405535013164 KMSKS motif; other site 405535013165 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 405535013166 tRNA binding surface [nucleotide binding]; other site 405535013167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535013168 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405535013169 putative substrate translocation pore; other site 405535013170 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 405535013171 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 405535013172 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 405535013173 TrkA-C domain; Region: TrkA_C; pfam02080 405535013174 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 405535013175 Int/Topo IB signature motif; other site 405535013176 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405535013177 FtsX-like permease family; Region: FtsX; pfam02687 405535013178 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405535013179 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405535013180 Walker A/P-loop; other site 405535013181 ATP binding site [chemical binding]; other site 405535013182 Q-loop/lid; other site 405535013183 ABC transporter signature motif; other site 405535013184 Walker B; other site 405535013185 D-loop; other site 405535013186 H-loop/switch region; other site 405535013187 Protein of unknown function (DUF418); Region: DUF418; cl12135 405535013188 Protein of unknown function (DUF418); Region: DUF418; pfam04235 405535013189 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 405535013190 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 405535013191 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405535013192 FeS/SAM binding site; other site 405535013193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535013194 S-adenosylmethionine binding site [chemical binding]; other site 405535013195 aspartate racemase; Region: asp_race; TIGR00035 405535013196 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 405535013197 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 405535013198 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 405535013199 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 405535013200 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 405535013201 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405535013202 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405535013203 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 405535013204 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 405535013205 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 405535013206 trimer interface [polypeptide binding]; other site 405535013207 putative metal binding site [ion binding]; other site 405535013208 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405535013209 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 405535013210 active site 405535013211 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405535013212 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 405535013213 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 405535013214 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 405535013215 GTP binding site; other site 405535013216 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 405535013217 MPT binding site; other site 405535013218 trimer interface [polypeptide binding]; other site 405535013219 S-adenosylmethionine synthetase; Validated; Region: PRK05250 405535013220 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 405535013221 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 405535013222 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 405535013223 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 405535013224 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 405535013225 active site 405535013226 substrate-binding site [chemical binding]; other site 405535013227 metal-binding site [ion binding] 405535013228 ATP binding site [chemical binding]; other site 405535013229 ATP synthase I chain; Region: ATP_synt_I; pfam03899 405535013230 EamA-like transporter family; Region: EamA; pfam00892 405535013231 EamA-like transporter family; Region: EamA; pfam00892 405535013232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 405535013233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535013234 ATP binding site [chemical binding]; other site 405535013235 Mg2+ binding site [ion binding]; other site 405535013236 G-X-G motif; other site 405535013237 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535013238 dimer interface [polypeptide binding]; other site 405535013239 phosphorylation site [posttranslational modification] 405535013240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535013241 ATP binding site [chemical binding]; other site 405535013242 Mg2+ binding site [ion binding]; other site 405535013243 G-X-G motif; other site 405535013244 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405535013245 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405535013246 Secretory lipase; Region: LIP; pfam03583 405535013247 Sulfatase; Region: Sulfatase; pfam00884 405535013248 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 405535013249 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 405535013250 NMT1-like family; Region: NMT1_2; pfam13379 405535013251 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 405535013252 Walker A/P-loop; other site 405535013253 ATP binding site [chemical binding]; other site 405535013254 ABC transporter; Region: ABC_tran; pfam00005 405535013255 Q-loop/lid; other site 405535013256 ABC transporter signature motif; other site 405535013257 Walker B; other site 405535013258 D-loop; other site 405535013259 H-loop/switch region; other site 405535013260 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 405535013261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535013262 dimer interface [polypeptide binding]; other site 405535013263 conserved gate region; other site 405535013264 putative PBP binding loops; other site 405535013265 ABC-ATPase subunit interface; other site 405535013266 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 405535013267 active site 405535013268 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 405535013269 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535013270 motif II; other site 405535013271 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 405535013272 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 405535013273 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 405535013274 nudix motif; other site 405535013275 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 405535013276 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 405535013277 S-ribosylhomocysteinase; Provisional; Region: PRK02260 405535013278 Haemolytic domain; Region: Haemolytic; pfam01809 405535013279 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 405535013280 active site clefts [active] 405535013281 zinc binding site [ion binding]; other site 405535013282 dimer interface [polypeptide binding]; other site 405535013283 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 405535013284 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 405535013285 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 405535013286 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 405535013287 S-layer homology domain; Region: SLH; pfam00395 405535013288 S-layer homology domain; Region: SLH; pfam00395 405535013289 S-layer homology domain; Region: SLH; pfam00395 405535013290 Excalibur calcium-binding domain; Region: Excalibur; smart00894 405535013291 Uncharacterized conserved protein [Function unknown]; Region: COG1434 405535013292 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 405535013293 putative active site [active] 405535013294 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405535013295 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405535013296 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405535013297 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405535013298 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 405535013299 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 405535013300 Predicted membrane protein [Function unknown]; Region: COG3766 405535013301 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 405535013302 hypothetical protein; Provisional; Region: PRK12473 405535013303 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 405535013304 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 405535013305 G1 box; other site 405535013306 GTP/Mg2+ binding site [chemical binding]; other site 405535013307 Switch I region; other site 405535013308 G2 box; other site 405535013309 G3 box; other site 405535013310 Switch II region; other site 405535013311 G4 box; other site 405535013312 G5 box; other site 405535013313 Nucleoside recognition; Region: Gate; pfam07670 405535013314 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 405535013315 Nucleoside recognition; Region: Gate; pfam07670 405535013316 FeoA domain; Region: FeoA; pfam04023 405535013317 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 405535013318 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535013319 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535013320 dimerization interface [polypeptide binding]; other site 405535013321 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535013322 dimer interface [polypeptide binding]; other site 405535013323 phosphorylation site [posttranslational modification] 405535013324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535013325 ATP binding site [chemical binding]; other site 405535013326 Mg2+ binding site [ion binding]; other site 405535013327 G-X-G motif; other site 405535013328 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535013329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535013330 active site 405535013331 phosphorylation site [posttranslational modification] 405535013332 intermolecular recognition site; other site 405535013333 dimerization interface [polypeptide binding]; other site 405535013334 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535013335 DNA binding site [nucleotide binding] 405535013336 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 405535013337 active site 405535013338 catalytic site [active] 405535013339 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405535013340 active site 405535013341 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 405535013342 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 405535013343 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 405535013344 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 405535013345 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405535013346 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 405535013347 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405535013348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535013349 S-adenosylmethionine binding site [chemical binding]; other site 405535013350 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405535013351 FtsX-like permease family; Region: FtsX; pfam02687 405535013352 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405535013353 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405535013354 Walker A/P-loop; other site 405535013355 ATP binding site [chemical binding]; other site 405535013356 Q-loop/lid; other site 405535013357 ABC transporter signature motif; other site 405535013358 Walker B; other site 405535013359 D-loop; other site 405535013360 H-loop/switch region; other site 405535013361 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405535013362 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405535013363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 405535013364 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535013365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535013366 active site 405535013367 phosphorylation site [posttranslational modification] 405535013368 intermolecular recognition site; other site 405535013369 dimerization interface [polypeptide binding]; other site 405535013370 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535013371 DNA binding site [nucleotide binding] 405535013372 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535013373 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 405535013374 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535013375 ATP binding site [chemical binding]; other site 405535013376 Mg2+ binding site [ion binding]; other site 405535013377 G-X-G motif; other site 405535013378 FtsX-like permease family; Region: FtsX; pfam02687 405535013379 FtsX-like permease family; Region: FtsX; pfam02687 405535013380 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405535013381 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405535013382 Walker A/P-loop; other site 405535013383 ATP binding site [chemical binding]; other site 405535013384 Q-loop/lid; other site 405535013385 ABC transporter signature motif; other site 405535013386 Walker B; other site 405535013387 D-loop; other site 405535013388 H-loop/switch region; other site 405535013389 FtsX-like permease family; Region: FtsX; pfam02687 405535013390 GntP family permease; Region: GntP_permease; pfam02447 405535013391 fructuronate transporter; Provisional; Region: PRK10034; cl15264 405535013392 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 405535013393 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405535013394 DNA-binding site [nucleotide binding]; DNA binding site 405535013395 UTRA domain; Region: UTRA; pfam07702 405535013396 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405535013397 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 405535013398 substrate binding site [chemical binding]; other site 405535013399 ATP binding site [chemical binding]; other site 405535013400 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 405535013401 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 405535013402 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405535013403 catalytic residue [active] 405535013404 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 405535013405 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 405535013406 active site 405535013407 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 405535013408 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535013409 dimerization interface [polypeptide binding]; other site 405535013410 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535013411 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535013412 dimer interface [polypeptide binding]; other site 405535013413 phosphorylation site [posttranslational modification] 405535013414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535013415 ATP binding site [chemical binding]; other site 405535013416 Mg2+ binding site [ion binding]; other site 405535013417 G-X-G motif; other site 405535013418 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535013419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535013420 active site 405535013421 phosphorylation site [posttranslational modification] 405535013422 intermolecular recognition site; other site 405535013423 dimerization interface [polypeptide binding]; other site 405535013424 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535013425 DNA binding site [nucleotide binding] 405535013426 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 405535013427 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 405535013428 active site 405535013429 octamer interface [polypeptide binding]; other site 405535013430 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 405535013431 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 405535013432 acyl-activating enzyme (AAE) consensus motif; other site 405535013433 putative AMP binding site [chemical binding]; other site 405535013434 putative active site [active] 405535013435 putative CoA binding site [chemical binding]; other site 405535013436 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405535013437 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 405535013438 substrate binding site [chemical binding]; other site 405535013439 oxyanion hole (OAH) forming residues; other site 405535013440 trimer interface [polypeptide binding]; other site 405535013441 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 405535013442 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 405535013443 nucleophilic elbow; other site 405535013444 catalytic triad; other site 405535013445 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 405535013446 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 405535013447 dimer interface [polypeptide binding]; other site 405535013448 tetramer interface [polypeptide binding]; other site 405535013449 PYR/PP interface [polypeptide binding]; other site 405535013450 TPP binding site [chemical binding]; other site 405535013451 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 405535013452 TPP-binding site; other site 405535013453 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 405535013454 chorismate binding enzyme; Region: Chorismate_bind; cl10555 405535013455 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 405535013456 UbiA prenyltransferase family; Region: UbiA; pfam01040 405535013457 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 405535013458 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405535013459 DNA-binding site [nucleotide binding]; DNA binding site 405535013460 RNA-binding motif; other site 405535013461 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 405535013462 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 405535013463 active site flap/lid [active] 405535013464 nucleophilic elbow; other site 405535013465 catalytic triad [active] 405535013466 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 405535013467 homodimer interface [polypeptide binding]; other site 405535013468 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 405535013469 active site pocket [active] 405535013470 glycogen synthase; Provisional; Region: glgA; PRK00654 405535013471 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 405535013472 ADP-binding pocket [chemical binding]; other site 405535013473 homodimer interface [polypeptide binding]; other site 405535013474 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 405535013475 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 405535013476 ligand binding site; other site 405535013477 oligomer interface; other site 405535013478 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 405535013479 dimer interface [polypeptide binding]; other site 405535013480 N-terminal domain interface [polypeptide binding]; other site 405535013481 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 405535013482 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 405535013483 ligand binding site; other site 405535013484 oligomer interface; other site 405535013485 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 405535013486 dimer interface [polypeptide binding]; other site 405535013487 N-terminal domain interface [polypeptide binding]; other site 405535013488 sulfate 1 binding site; other site 405535013489 glycogen branching enzyme; Provisional; Region: PRK12313 405535013490 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 405535013491 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 405535013492 active site 405535013493 catalytic site [active] 405535013494 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 405535013495 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 405535013496 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 405535013497 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405535013498 NAD binding site [chemical binding]; other site 405535013499 dimer interface [polypeptide binding]; other site 405535013500 substrate binding site [chemical binding]; other site 405535013501 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 405535013502 MgtC family; Region: MgtC; pfam02308 405535013503 Ion channel; Region: Ion_trans_2; pfam07885 405535013504 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 405535013505 TrkA-N domain; Region: TrkA_N; pfam02254 405535013506 YugN-like family; Region: YugN; pfam08868 405535013507 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 405535013508 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 405535013509 active site 405535013510 dimer interface [polypeptide binding]; other site 405535013511 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 405535013512 dimer interface [polypeptide binding]; other site 405535013513 active site 405535013514 Domain of unknown function (DUF378); Region: DUF378; pfam04070 405535013515 general stress protein 13; Validated; Region: PRK08059 405535013516 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 405535013517 RNA binding site [nucleotide binding]; other site 405535013518 hypothetical protein; Validated; Region: PRK07682 405535013519 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405535013520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535013521 homodimer interface [polypeptide binding]; other site 405535013522 catalytic residue [active] 405535013523 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 405535013524 AsnC family; Region: AsnC_trans_reg; pfam01037 405535013525 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 405535013526 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 405535013527 dimerization interface [polypeptide binding]; other site 405535013528 ligand binding site [chemical binding]; other site 405535013529 NADP binding site [chemical binding]; other site 405535013530 catalytic site [active] 405535013531 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 405535013532 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405535013533 nucleophilic elbow; other site 405535013534 catalytic triad; other site 405535013535 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 405535013536 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 405535013537 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405535013538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535013539 homodimer interface [polypeptide binding]; other site 405535013540 catalytic residue [active] 405535013541 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 405535013542 E-class dimer interface [polypeptide binding]; other site 405535013543 P-class dimer interface [polypeptide binding]; other site 405535013544 active site 405535013545 Cu2+ binding site [ion binding]; other site 405535013546 Zn2+ binding site [ion binding]; other site 405535013547 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 405535013548 Kinase associated protein B; Region: KapB; pfam08810 405535013549 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 405535013550 active site 405535013551 catalytic site [active] 405535013552 substrate binding site [chemical binding]; other site 405535013553 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 405535013554 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 405535013555 transmembrane helices; other site 405535013556 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 405535013557 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 405535013558 active site 405535013559 glycyl-tRNA synthetase; Provisional; Region: PRK04173 405535013560 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 405535013561 motif 1; other site 405535013562 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 405535013563 active site 405535013564 motif 2; other site 405535013565 motif 3; other site 405535013566 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 405535013567 anticodon binding site; other site 405535013568 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 405535013569 CoenzymeA binding site [chemical binding]; other site 405535013570 subunit interaction site [polypeptide binding]; other site 405535013571 PHB binding site; other site 405535013572 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 405535013573 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 405535013574 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 405535013575 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 405535013576 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 405535013577 active site 405535013578 tetramer interface; other site 405535013579 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 405535013580 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 405535013581 active site 405535013582 substrate binding site [chemical binding]; other site 405535013583 metal binding site [ion binding]; metal-binding site 405535013584 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 405535013585 Uncharacterized conserved protein [Function unknown]; Region: COG1624 405535013586 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 405535013587 multifunctional aminopeptidase A; Provisional; Region: PRK00913 405535013588 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 405535013589 interface (dimer of trimers) [polypeptide binding]; other site 405535013590 Substrate-binding/catalytic site; other site 405535013591 Zn-binding sites [ion binding]; other site 405535013592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 405535013593 Putative membrane protein; Region: YuiB; pfam14068 405535013594 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405535013595 nudix motif; other site 405535013596 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 405535013597 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405535013598 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 405535013599 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405535013600 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405535013601 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405535013602 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405535013603 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405535013604 Domain of unknown function DUF11; Region: DUF11; cl17728 405535013605 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405535013606 Domain of unknown function DUF11; Region: DUF11; pfam01345 405535013607 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405535013608 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405535013609 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405535013610 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405535013611 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405535013612 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405535013613 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405535013614 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405535013615 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405535013616 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405535013617 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405535013618 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405535013619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 405535013620 H+ Antiporter protein; Region: 2A0121; TIGR00900 405535013621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535013622 putative substrate translocation pore; other site 405535013623 Helix-turn-helix domain; Region: HTH_36; pfam13730 405535013624 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 405535013625 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 405535013626 putative DNA binding site [nucleotide binding]; other site 405535013627 dimerization interface [polypeptide binding]; other site 405535013628 Protein of unknown function (DUF523); Region: DUF523; pfam04463 405535013629 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405535013630 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 405535013631 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 405535013632 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 405535013633 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 405535013634 hypothetical protein; Provisional; Region: PRK13669 405535013635 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 405535013636 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405535013637 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 405535013638 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405535013639 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535013640 Walker A/P-loop; other site 405535013641 ATP binding site [chemical binding]; other site 405535013642 Q-loop/lid; other site 405535013643 ABC transporter signature motif; other site 405535013644 Walker B; other site 405535013645 D-loop; other site 405535013646 H-loop/switch region; other site 405535013647 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 405535013648 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 405535013649 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 405535013650 PhnA protein; Region: PhnA; pfam03831 405535013651 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 405535013652 CAAX protease self-immunity; Region: Abi; pfam02517 405535013653 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 405535013654 active site 405535013655 NTP binding site [chemical binding]; other site 405535013656 metal binding triad [ion binding]; metal-binding site 405535013657 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 405535013658 NifU-like domain; Region: NifU; pfam01106 405535013659 spore coat protein YutH; Region: spore_yutH; TIGR02905 405535013660 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 405535013661 tetramer interfaces [polypeptide binding]; other site 405535013662 binuclear metal-binding site [ion binding]; other site 405535013663 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405535013664 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405535013665 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 405535013666 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405535013667 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 405535013668 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535013669 active site 405535013670 motif I; other site 405535013671 motif II; other site 405535013672 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535013673 Predicted transcriptional regulator [Transcription]; Region: COG2345 405535013674 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535013675 putative Zn2+ binding site [ion binding]; other site 405535013676 putative DNA binding site [nucleotide binding]; other site 405535013677 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 405535013678 Uncharacterized conserved protein [Function unknown]; Region: COG2445 405535013679 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 405535013680 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 405535013681 putative active site [active] 405535013682 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 405535013683 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 405535013684 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405535013685 RNA binding surface [nucleotide binding]; other site 405535013686 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 405535013687 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 405535013688 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405535013689 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 405535013690 DNA binding residues [nucleotide binding] 405535013691 dimer interface [polypeptide binding]; other site 405535013692 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 405535013693 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 405535013694 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405535013695 catalytic core [active] 405535013696 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 405535013697 putative deacylase active site [active] 405535013698 lipoyl synthase; Provisional; Region: PRK05481 405535013699 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405535013700 FeS/SAM binding site; other site 405535013701 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405535013702 Peptidase family M23; Region: Peptidase_M23; pfam01551 405535013703 sporulation protein YunB; Region: spo_yunB; TIGR02832 405535013704 Uncharacterized conserved protein [Function unknown]; Region: COG3377 405535013705 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 405535013706 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 405535013707 active site 405535013708 metal binding site [ion binding]; metal-binding site 405535013709 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405535013710 Predicted transcriptional regulators [Transcription]; Region: COG1695 405535013711 Transcriptional regulator PadR-like family; Region: PadR; cl17335 405535013712 VanZ like family; Region: VanZ; pfam04892 405535013713 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 405535013714 FeS assembly protein SufB; Region: sufB; TIGR01980 405535013715 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 405535013716 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 405535013717 trimerization site [polypeptide binding]; other site 405535013718 active site 405535013719 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 405535013720 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 405535013721 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405535013722 catalytic residue [active] 405535013723 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 405535013724 FeS assembly protein SufD; Region: sufD; TIGR01981 405535013725 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 405535013726 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 405535013727 Walker A/P-loop; other site 405535013728 ATP binding site [chemical binding]; other site 405535013729 Q-loop/lid; other site 405535013730 ABC transporter signature motif; other site 405535013731 Walker B; other site 405535013732 D-loop; other site 405535013733 H-loop/switch region; other site 405535013734 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 405535013735 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 405535013736 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 405535013737 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 405535013738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535013739 ABC-ATPase subunit interface; other site 405535013740 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 405535013741 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 405535013742 Walker A/P-loop; other site 405535013743 ATP binding site [chemical binding]; other site 405535013744 Q-loop/lid; other site 405535013745 ABC transporter signature motif; other site 405535013746 Walker B; other site 405535013747 D-loop; other site 405535013748 H-loop/switch region; other site 405535013749 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 405535013750 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405535013751 catalytic residues [active] 405535013752 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 405535013753 putative active site [active] 405535013754 putative metal binding site [ion binding]; other site 405535013755 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 405535013756 lipoyl attachment site [posttranslational modification]; other site 405535013757 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 405535013758 ArsC family; Region: ArsC; pfam03960 405535013759 putative ArsC-like catalytic residues; other site 405535013760 putative TRX-like catalytic residues [active] 405535013761 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 405535013762 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 405535013763 active site 405535013764 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 405535013765 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 405535013766 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 405535013767 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 405535013768 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405535013769 NAD binding site [chemical binding]; other site 405535013770 dimer interface [polypeptide binding]; other site 405535013771 substrate binding site [chemical binding]; other site 405535013772 Coat F domain; Region: Coat_F; pfam07875 405535013773 CAAX protease self-immunity; Region: Abi; pfam02517 405535013774 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535013775 salt bridge; other site 405535013776 non-specific DNA binding site [nucleotide binding]; other site 405535013777 sequence-specific DNA binding site [nucleotide binding]; other site 405535013778 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535013779 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535013780 WHG domain; Region: WHG; pfam13305 405535013781 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405535013782 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 405535013783 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405535013784 active site 405535013785 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 405535013786 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 405535013787 dimer interface [polypeptide binding]; other site 405535013788 active site 405535013789 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 405535013790 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 405535013791 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 405535013792 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 405535013793 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405535013794 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 405535013795 substrate binding site [chemical binding]; other site 405535013796 oxyanion hole (OAH) forming residues; other site 405535013797 YuzL-like protein; Region: YuzL; pfam14115 405535013798 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405535013799 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 405535013800 Proline dehydrogenase; Region: Pro_dh; cl03282 405535013801 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 405535013802 Domain of unknown function DUF77; Region: DUF77; pfam01910 405535013803 Cache domain; Region: Cache_1; pfam02743 405535013804 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535013805 dimerization interface [polypeptide binding]; other site 405535013806 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405535013807 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405535013808 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405535013809 dimer interface [polypeptide binding]; other site 405535013810 putative CheW interface [polypeptide binding]; other site 405535013811 Predicted transcriptional regulators [Transcription]; Region: COG1378 405535013812 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 405535013813 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 405535013814 C-terminal domain interface [polypeptide binding]; other site 405535013815 sugar binding site [chemical binding]; other site 405535013816 TQXA domain; Region: TQXA_dom; TIGR03934 405535013817 Cna protein B-type domain; Region: Cna_B; pfam05738 405535013818 Cna protein B-type domain; Region: Cna_B; pfam05738 405535013819 Cna protein B-type domain; Region: Cna_B; pfam05738 405535013820 Cna protein B-type domain; Region: Cna_B; pfam05738 405535013821 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 405535013822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535013823 putative substrate translocation pore; other site 405535013824 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 405535013825 Spore germination protein; Region: Spore_permease; cl17796 405535013826 MAEBL; Provisional; Region: PTZ00121 405535013827 OxaA-like protein precursor; Validated; Region: PRK01622 405535013828 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405535013829 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405535013830 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405535013831 hypothetical protein; Provisional; Region: PRK06758 405535013832 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 405535013833 active site 405535013834 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535013835 non-specific DNA binding site [nucleotide binding]; other site 405535013836 salt bridge; other site 405535013837 sequence-specific DNA binding site [nucleotide binding]; other site 405535013838 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405535013839 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405535013840 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 405535013841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 405535013842 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405535013843 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535013844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535013845 active site 405535013846 phosphorylation site [posttranslational modification] 405535013847 intermolecular recognition site; other site 405535013848 dimerization interface [polypeptide binding]; other site 405535013849 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535013850 DNA binding site [nucleotide binding] 405535013851 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535013852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535013853 dimer interface [polypeptide binding]; other site 405535013854 phosphorylation site [posttranslational modification] 405535013855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535013856 ATP binding site [chemical binding]; other site 405535013857 Mg2+ binding site [ion binding]; other site 405535013858 G-X-G motif; other site 405535013859 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405535013860 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 405535013861 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 405535013862 active site 405535013863 HIGH motif; other site 405535013864 KMSKS motif; other site 405535013865 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 405535013866 tRNA binding surface [nucleotide binding]; other site 405535013867 anticodon binding site; other site 405535013868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535013869 S-adenosylmethionine binding site [chemical binding]; other site 405535013870 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535013871 dimerization interface [polypeptide binding]; other site 405535013872 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405535013873 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405535013874 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405535013875 dimer interface [polypeptide binding]; other site 405535013876 putative CheW interface [polypeptide binding]; other site 405535013877 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 405535013878 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535013879 dimerization interface [polypeptide binding]; other site 405535013880 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405535013881 dimer interface [polypeptide binding]; other site 405535013882 putative CheW interface [polypeptide binding]; other site 405535013883 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 405535013884 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405535013885 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405535013886 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 405535013887 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 405535013888 active site 405535013889 Zn binding site [ion binding]; other site 405535013890 Pirin-related protein [General function prediction only]; Region: COG1741 405535013891 Pirin; Region: Pirin; pfam02678 405535013892 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405535013893 MarR family; Region: MarR_2; pfam12802 405535013894 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 405535013895 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 405535013896 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 405535013897 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 405535013898 TrkA-C domain; Region: TrkA_C; pfam02080 405535013899 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405535013900 amino acid carrier protein; Region: agcS; TIGR00835 405535013901 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 405535013902 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 405535013903 dimerization interface [polypeptide binding]; other site 405535013904 DPS ferroxidase diiron center [ion binding]; other site 405535013905 ion pore; other site 405535013906 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 405535013907 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 405535013908 metal binding site [ion binding]; metal-binding site 405535013909 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 405535013910 Ferritin-like domain; Region: Ferritin; pfam00210 405535013911 ferroxidase diiron center [ion binding]; other site 405535013912 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405535013913 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405535013914 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405535013915 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405535013916 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405535013917 Nucleoside recognition; Region: Gate; pfam07670 405535013918 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405535013919 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405535013920 amino acid carrier protein; Region: agcS; TIGR00835 405535013921 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 405535013922 NADH(P)-binding; Region: NAD_binding_10; pfam13460 405535013923 NAD binding site [chemical binding]; other site 405535013924 substrate binding site [chemical binding]; other site 405535013925 putative active site [active] 405535013926 Peptidase M60-like family; Region: M60-like; pfam13402 405535013927 Viral enhancin protein; Region: Enhancin; pfam03272 405535013928 Peptidase M60-like family; Region: M60-like; pfam13402 405535013929 TQXA domain; Region: TQXA_dom; TIGR03934 405535013930 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405535013931 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405535013932 active site 405535013933 catalytic tetrad [active] 405535013934 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 405535013935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535013936 putative substrate translocation pore; other site 405535013937 Predicted transcriptional regulators [Transcription]; Region: COG1733 405535013938 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535013939 dimerization interface [polypeptide binding]; other site 405535013940 putative DNA binding site [nucleotide binding]; other site 405535013941 putative Zn2+ binding site [ion binding]; other site 405535013942 Uncharacterized conserved protein [Function unknown]; Region: COG2427 405535013943 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 405535013944 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405535013945 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 405535013946 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 405535013947 active site 405535013948 HIGH motif; other site 405535013949 dimer interface [polypeptide binding]; other site 405535013950 KMSKS motif; other site 405535013951 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405535013952 RNA binding surface [nucleotide binding]; other site 405535013953 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 405535013954 FAD binding domain; Region: FAD_binding_4; pfam01565 405535013955 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 405535013956 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 405535013957 SET domain; Region: SET; pfam00856 405535013958 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 405535013959 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405535013960 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405535013961 dimer interface [polypeptide binding]; other site 405535013962 putative CheW interface [polypeptide binding]; other site 405535013963 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 405535013964 putative phosphate binding site [ion binding]; other site 405535013965 camphor resistance protein CrcB; Provisional; Region: PRK14219 405535013966 camphor resistance protein CrcB; Provisional; Region: PRK14205 405535013967 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 405535013968 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 405535013969 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405535013970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535013971 Coenzyme A binding pocket [chemical binding]; other site 405535013972 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 405535013973 Nuclease-related domain; Region: NERD; pfam08378 405535013974 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 405535013975 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405535013976 Walker A/P-loop; other site 405535013977 ATP binding site [chemical binding]; other site 405535013978 Q-loop/lid; other site 405535013979 ABC transporter signature motif; other site 405535013980 Walker B; other site 405535013981 D-loop; other site 405535013982 H-loop/switch region; other site 405535013983 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405535013984 ABC-ATPase subunit interface; other site 405535013985 dimer interface [polypeptide binding]; other site 405535013986 putative PBP binding regions; other site 405535013987 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405535013988 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405535013989 ABC-ATPase subunit interface; other site 405535013990 dimer interface [polypeptide binding]; other site 405535013991 putative PBP binding regions; other site 405535013992 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 405535013993 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 405535013994 putative ligand binding residues [chemical binding]; other site 405535013995 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535013996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535013997 active site 405535013998 phosphorylation site [posttranslational modification] 405535013999 intermolecular recognition site; other site 405535014000 dimerization interface [polypeptide binding]; other site 405535014001 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535014002 DNA binding site [nucleotide binding] 405535014003 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535014004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535014005 ATP binding site [chemical binding]; other site 405535014006 Mg2+ binding site [ion binding]; other site 405535014007 G-X-G motif; other site 405535014008 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535014009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535014010 active site 405535014011 phosphorylation site [posttranslational modification] 405535014012 intermolecular recognition site; other site 405535014013 dimerization interface [polypeptide binding]; other site 405535014014 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535014015 DNA binding site [nucleotide binding] 405535014016 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405535014017 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405535014018 Walker A/P-loop; other site 405535014019 ATP binding site [chemical binding]; other site 405535014020 Q-loop/lid; other site 405535014021 ABC transporter signature motif; other site 405535014022 Walker B; other site 405535014023 D-loop; other site 405535014024 H-loop/switch region; other site 405535014025 FtsX-like permease family; Region: FtsX; pfam02687 405535014026 Protein of unknown function (DUF418); Region: DUF418; cl12135 405535014027 Protein of unknown function (DUF418); Region: DUF418; pfam04235 405535014028 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405535014029 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405535014030 Walker A/P-loop; other site 405535014031 ATP binding site [chemical binding]; other site 405535014032 Q-loop/lid; other site 405535014033 ABC transporter signature motif; other site 405535014034 Walker B; other site 405535014035 D-loop; other site 405535014036 H-loop/switch region; other site 405535014037 Protein of unknown function (DUF4027); Region: DUF4027; pfam13219 405535014038 Protein of unknown function (DUF4027); Region: DUF4027; pfam13219 405535014039 Protein of unknown function (DUF4027); Region: DUF4027; pfam13219 405535014040 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405535014041 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535014042 Coenzyme A binding pocket [chemical binding]; other site 405535014043 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 405535014044 SmpB-tmRNA interface; other site 405535014045 ribonuclease R; Region: RNase_R; TIGR02063 405535014046 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 405535014047 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 405535014048 RNB domain; Region: RNB; pfam00773 405535014049 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 405535014050 RNA binding site [nucleotide binding]; other site 405535014051 Esterase/lipase [General function prediction only]; Region: COG1647 405535014052 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 405535014053 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 405535014054 holin-like protein; Validated; Region: PRK01658 405535014055 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 405535014056 active site 405535014057 enolase; Provisional; Region: eno; PRK00077 405535014058 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 405535014059 dimer interface [polypeptide binding]; other site 405535014060 metal binding site [ion binding]; metal-binding site 405535014061 substrate binding pocket [chemical binding]; other site 405535014062 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 405535014063 phosphoglyceromutase; Provisional; Region: PRK05434 405535014064 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 405535014065 triosephosphate isomerase; Provisional; Region: PRK14565 405535014066 substrate binding site [chemical binding]; other site 405535014067 dimer interface [polypeptide binding]; other site 405535014068 catalytic triad [active] 405535014069 Phosphoglycerate kinase; Region: PGK; pfam00162 405535014070 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 405535014071 substrate binding site [chemical binding]; other site 405535014072 hinge regions; other site 405535014073 ADP binding site [chemical binding]; other site 405535014074 catalytic site [active] 405535014075 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 405535014076 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 405535014077 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 405535014078 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 405535014079 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 405535014080 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 405535014081 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 405535014082 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 405535014083 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 405535014084 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 405535014085 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 405535014086 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 405535014087 stage V sporulation protein AD; Provisional; Region: PRK12404 405535014088 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 405535014089 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 405535014090 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 405535014091 Predicted membrane protein [Function unknown]; Region: COG2323 405535014092 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 405535014093 Clp protease; Region: CLP_protease; pfam00574 405535014094 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 405535014095 oligomer interface [polypeptide binding]; other site 405535014096 active site residues [active] 405535014097 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 405535014098 dimerization domain swap beta strand [polypeptide binding]; other site 405535014099 regulatory protein interface [polypeptide binding]; other site 405535014100 active site 405535014101 regulatory phosphorylation site [posttranslational modification]; other site 405535014102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 405535014103 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 405535014104 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 405535014105 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 405535014106 phosphate binding site [ion binding]; other site 405535014107 putative substrate binding pocket [chemical binding]; other site 405535014108 dimer interface [polypeptide binding]; other site 405535014109 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 405535014110 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 405535014111 putative active site [active] 405535014112 nucleotide binding site [chemical binding]; other site 405535014113 nudix motif; other site 405535014114 putative metal binding site [ion binding]; other site 405535014115 Domain of unknown function (DUF368); Region: DUF368; pfam04018 405535014116 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 405535014117 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405535014118 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405535014119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535014120 binding surface 405535014121 TPR motif; other site 405535014122 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405535014123 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535014124 binding surface 405535014125 Tetratricopeptide repeat; Region: TPR_16; pfam13432 405535014126 TPR motif; other site 405535014127 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 405535014128 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 405535014129 trimer interface [polypeptide binding]; other site 405535014130 active site 405535014131 substrate binding site [chemical binding]; other site 405535014132 CoA binding site [chemical binding]; other site 405535014133 pyrophosphatase PpaX; Provisional; Region: PRK13288 405535014134 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535014135 active site 405535014136 motif I; other site 405535014137 motif II; other site 405535014138 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 405535014139 HPr kinase/phosphorylase; Provisional; Region: PRK05428 405535014140 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 405535014141 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 405535014142 Hpr binding site; other site 405535014143 active site 405535014144 homohexamer subunit interaction site [polypeptide binding]; other site 405535014145 Predicted membrane protein [Function unknown]; Region: COG1950 405535014146 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 405535014147 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 405535014148 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 405535014149 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 405535014150 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 405535014151 excinuclease ABC subunit B; Provisional; Region: PRK05298 405535014152 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405535014153 ATP binding site [chemical binding]; other site 405535014154 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405535014155 nucleotide binding region [chemical binding]; other site 405535014156 ATP-binding site [chemical binding]; other site 405535014157 Ultra-violet resistance protein B; Region: UvrB; pfam12344 405535014158 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 405535014159 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 405535014160 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405535014161 DNA binding residues [nucleotide binding] 405535014162 dimer interface [polypeptide binding]; other site 405535014163 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 405535014164 potential frameshift: common BLAST hit: gi|52140393|ref|YP_086437.1| group-specific protein 405535014165 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405535014166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535014167 non-specific DNA binding site [nucleotide binding]; other site 405535014168 salt bridge; other site 405535014169 sequence-specific DNA binding site [nucleotide binding]; other site 405535014170 Predicted membrane protein [Function unknown]; Region: COG2855 405535014171 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405535014172 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405535014173 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 405535014174 putative dimerization interface [polypeptide binding]; other site 405535014175 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 405535014176 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405535014177 DNA binding residues [nucleotide binding] 405535014178 putative dimer interface [polypeptide binding]; other site 405535014179 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 405535014180 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405535014181 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405535014182 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 405535014183 ABC transporter; Region: ABC_tran_2; pfam12848 405535014184 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405535014185 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405535014186 hypothetical protein; Provisional; Region: PRK12855 405535014187 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405535014188 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405535014189 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 405535014190 Walker A/P-loop; other site 405535014191 ATP binding site [chemical binding]; other site 405535014192 Q-loop/lid; other site 405535014193 ABC transporter signature motif; other site 405535014194 Walker B; other site 405535014195 D-loop; other site 405535014196 H-loop/switch region; other site 405535014197 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 405535014198 protein binding site [polypeptide binding]; other site 405535014199 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 405535014200 C-terminal peptidase (prc); Region: prc; TIGR00225 405535014201 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 405535014202 protein binding site [polypeptide binding]; other site 405535014203 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 405535014204 Catalytic dyad [active] 405535014205 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 405535014206 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 405535014207 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 405535014208 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535014209 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 405535014210 Walker A/P-loop; other site 405535014211 ATP binding site [chemical binding]; other site 405535014212 Q-loop/lid; other site 405535014213 ABC transporter signature motif; other site 405535014214 Walker B; other site 405535014215 D-loop; other site 405535014216 H-loop/switch region; other site 405535014217 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 405535014218 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 405535014219 peptide chain release factor 2; Provisional; Region: PRK06746 405535014220 This domain is found in peptide chain release factors; Region: PCRF; smart00937 405535014221 RF-1 domain; Region: RF-1; pfam00472 405535014222 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 405535014223 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 405535014224 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 405535014225 nucleotide binding region [chemical binding]; other site 405535014226 ATP-binding site [chemical binding]; other site 405535014227 SEC-C motif; Region: SEC-C; pfam02810 405535014228 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 405535014229 30S subunit binding site; other site 405535014230 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405535014231 DNA-binding site [nucleotide binding]; DNA binding site 405535014232 RNA-binding motif; other site 405535014233 comF family protein; Region: comF; TIGR00201 405535014234 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405535014235 active site 405535014236 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 405535014237 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405535014238 ATP binding site [chemical binding]; other site 405535014239 putative Mg++ binding site [ion binding]; other site 405535014240 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405535014241 nucleotide binding region [chemical binding]; other site 405535014242 ATP-binding site [chemical binding]; other site 405535014243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 405535014244 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405535014245 NlpC/P60 family; Region: NLPC_P60; pfam00877 405535014246 Predicted transcriptional regulators [Transcription]; Region: COG1733 405535014247 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535014248 dimerization interface [polypeptide binding]; other site 405535014249 putative DNA binding site [nucleotide binding]; other site 405535014250 putative Zn2+ binding site [ion binding]; other site 405535014251 EDD domain protein, DegV family; Region: DegV; TIGR00762 405535014252 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 405535014253 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 405535014254 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 405535014255 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 405535014256 Transcriptional regulator [Transcription]; Region: LytR; COG1316 405535014257 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 405535014258 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 405535014259 active site 405535014260 homodimer interface [polypeptide binding]; other site 405535014261 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 405535014262 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 405535014263 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 405535014264 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 405535014265 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 405535014266 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 405535014267 Mg++ binding site [ion binding]; other site 405535014268 putative catalytic motif [active] 405535014269 substrate binding site [chemical binding]; other site 405535014270 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405535014271 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 405535014272 NodB motif; other site 405535014273 active site 405535014274 catalytic site [active] 405535014275 Zn binding site [ion binding]; other site 405535014276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405535014277 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 405535014278 Walker A motif; other site 405535014279 ATP binding site [chemical binding]; other site 405535014280 Walker B motif; other site 405535014281 arginine finger; other site 405535014282 Transcriptional antiterminator [Transcription]; Region: COG3933 405535014283 PRD domain; Region: PRD; pfam00874 405535014284 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 405535014285 active pocket/dimerization site; other site 405535014286 active site 405535014287 phosphorylation site [posttranslational modification] 405535014288 PRD domain; Region: PRD; pfam00874 405535014289 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 405535014290 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 405535014291 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 405535014292 Chromate transporter; Region: Chromate_transp; pfam02417 405535014293 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 405535014294 putative active site [active] 405535014295 YdjC motif; other site 405535014296 Mg binding site [ion binding]; other site 405535014297 putative homodimer interface [polypeptide binding]; other site 405535014298 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 405535014299 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 405535014300 NAD binding site [chemical binding]; other site 405535014301 sugar binding site [chemical binding]; other site 405535014302 divalent metal binding site [ion binding]; other site 405535014303 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405535014304 dimer interface [polypeptide binding]; other site 405535014305 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 405535014306 active site 405535014307 methionine cluster; other site 405535014308 phosphorylation site [posttranslational modification] 405535014309 metal binding site [ion binding]; metal-binding site 405535014310 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 405535014311 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 405535014312 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 405535014313 spermidine synthase; Provisional; Region: PRK03612 405535014314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535014315 S-adenosylmethionine binding site [chemical binding]; other site 405535014316 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 405535014317 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 405535014318 methionine cluster; other site 405535014319 active site 405535014320 phosphorylation site [posttranslational modification] 405535014321 metal binding site [ion binding]; metal-binding site 405535014322 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 405535014323 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 405535014324 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 405535014325 active site 405535014326 P-loop; other site 405535014327 phosphorylation site [posttranslational modification] 405535014328 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 405535014329 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405535014330 Acyltransferase family; Region: Acyl_transf_3; pfam01757 405535014331 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 405535014332 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405535014333 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 405535014334 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 405535014335 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 405535014336 Predicted membrane protein [Function unknown]; Region: COG1511 405535014337 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 405535014338 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405535014339 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405535014340 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 405535014341 putative dimerization interface [polypeptide binding]; other site 405535014342 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 405535014343 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 405535014344 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 405535014345 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 405535014346 transmembrane helices; other site 405535014347 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 405535014348 ThiC-associated domain; Region: ThiC-associated; pfam13667 405535014349 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 405535014350 L-lactate permease; Region: Lactate_perm; cl00701 405535014351 glycolate transporter; Provisional; Region: PRK09695 405535014352 Tic20-like protein; Region: Tic20; pfam09685 405535014353 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 405535014354 Uncharacterized conserved protein [Function unknown]; Region: COG3339 405535014355 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 405535014356 Sulfatase; Region: Sulfatase; pfam00884 405535014357 putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ; Provisional; Region: PRK09677 405535014358 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 405535014359 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 405535014360 homodimer interface [polypeptide binding]; other site 405535014361 substrate-cofactor binding pocket; other site 405535014362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535014363 catalytic residue [active] 405535014364 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535014365 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535014366 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535014367 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535014368 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535014369 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405535014370 NlpC/P60 family; Region: NLPC_P60; pfam00877 405535014371 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405535014372 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405535014373 Nucleoside recognition; Region: Gate; pfam07670 405535014374 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405535014375 Uncharacterized conserved protein (DUF2215); Region: DUF2215; pfam10225 405535014376 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 405535014377 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 405535014378 DXD motif; other site 405535014379 BCCT family transporter; Region: BCCT; pfam02028 405535014380 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535014381 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535014382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 405535014383 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 405535014384 Predicted membrane protein [Function unknown]; Region: COG4640 405535014385 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 405535014386 Double zinc ribbon; Region: DZR; pfam12773 405535014387 Double zinc ribbon; Region: DZR; pfam12773 405535014388 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 405535014389 SNF2 Helicase protein; Region: DUF3670; pfam12419 405535014390 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 405535014391 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405535014392 ATP binding site [chemical binding]; other site 405535014393 putative Mg++ binding site [ion binding]; other site 405535014394 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 405535014395 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405535014396 nucleotide binding region [chemical binding]; other site 405535014397 ATP-binding site [chemical binding]; other site 405535014398 Predicted integral membrane protein [Function unknown]; Region: COG5652 405535014399 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 405535014400 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 405535014401 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 405535014402 ComK protein; Region: ComK; pfam06338 405535014403 RNA polymerase factor sigma-70; Validated; Region: PRK06759 405535014404 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535014405 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405535014406 DNA binding residues [nucleotide binding] 405535014407 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 405535014408 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 405535014409 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405535014410 FtsX-like permease family; Region: FtsX; pfam02687 405535014411 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405535014412 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405535014413 Walker A/P-loop; other site 405535014414 ATP binding site [chemical binding]; other site 405535014415 Q-loop/lid; other site 405535014416 ABC transporter signature motif; other site 405535014417 Walker B; other site 405535014418 D-loop; other site 405535014419 H-loop/switch region; other site 405535014420 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 405535014421 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 405535014422 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 405535014423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535014424 putative substrate translocation pore; other site 405535014425 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 405535014426 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 405535014427 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 405535014428 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 405535014429 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405535014430 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535014431 dimerization interface [polypeptide binding]; other site 405535014432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535014433 dimer interface [polypeptide binding]; other site 405535014434 phosphorylation site [posttranslational modification] 405535014435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535014436 ATP binding site [chemical binding]; other site 405535014437 Mg2+ binding site [ion binding]; other site 405535014438 G-X-G motif; other site 405535014439 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535014440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535014441 active site 405535014442 phosphorylation site [posttranslational modification] 405535014443 intermolecular recognition site; other site 405535014444 dimerization interface [polypeptide binding]; other site 405535014445 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535014446 DNA binding site [nucleotide binding] 405535014447 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 405535014448 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 405535014449 NAD binding site [chemical binding]; other site 405535014450 homodimer interface [polypeptide binding]; other site 405535014451 active site 405535014452 substrate binding site [chemical binding]; other site 405535014453 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 405535014454 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 405535014455 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 405535014456 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 405535014457 active site 405535014458 homodimer interface [polypeptide binding]; other site 405535014459 teichoic acids export protein ATP-binding subunit; Provisional; Region: tagH; PRK13545 405535014460 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 405535014461 Walker A/P-loop; other site 405535014462 ATP binding site [chemical binding]; other site 405535014463 Q-loop/lid; other site 405535014464 ABC transporter signature motif; other site 405535014465 Walker B; other site 405535014466 D-loop; other site 405535014467 H-loop/switch region; other site 405535014468 Bacterial SH3 domain homologues; Region: SH3b; smart00287 405535014469 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 405535014470 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 405535014471 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 405535014472 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 405535014473 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 405535014474 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 405535014475 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405535014476 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 405535014477 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 405535014478 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405535014479 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 405535014480 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 405535014481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 405535014482 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 405535014483 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 405535014484 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405535014485 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 405535014486 putative glycosyl transferase; Provisional; Region: PRK10307 405535014487 rod shape-determining protein Mbl; Provisional; Region: PRK13928 405535014488 MreB and similar proteins; Region: MreB_like; cd10225 405535014489 nucleotide binding site [chemical binding]; other site 405535014490 Mg binding site [ion binding]; other site 405535014491 putative protofilament interaction site [polypeptide binding]; other site 405535014492 RodZ interaction site [polypeptide binding]; other site 405535014493 Stage III sporulation protein D; Region: SpoIIID; cl17560 405535014494 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 405535014495 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405535014496 Peptidase family M23; Region: Peptidase_M23; pfam01551 405535014497 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 405535014498 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 405535014499 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405535014500 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405535014501 Walker A/P-loop; other site 405535014502 ATP binding site [chemical binding]; other site 405535014503 Q-loop/lid; other site 405535014504 ABC transporter signature motif; other site 405535014505 Walker B; other site 405535014506 D-loop; other site 405535014507 H-loop/switch region; other site 405535014508 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405535014509 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405535014510 Walker A/P-loop; other site 405535014511 ATP binding site [chemical binding]; other site 405535014512 Q-loop/lid; other site 405535014513 ABC transporter signature motif; other site 405535014514 Walker B; other site 405535014515 D-loop; other site 405535014516 H-loop/switch region; other site 405535014517 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 405535014518 LytTr DNA-binding domain; Region: LytTR; pfam04397 405535014519 Stage II sporulation protein; Region: SpoIID; pfam08486 405535014520 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 405535014521 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 405535014522 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 405535014523 hinge; other site 405535014524 active site 405535014525 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 405535014526 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 405535014527 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 405535014528 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 405535014529 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 405535014530 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 405535014531 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 405535014532 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 405535014533 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 405535014534 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 405535014535 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 405535014536 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 405535014537 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 405535014538 4Fe-4S binding domain; Region: Fer4; cl02805 405535014539 4Fe-4S binding domain; Region: Fer4; pfam00037 405535014540 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 405535014541 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 405535014542 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 405535014543 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 405535014544 NADH dehydrogenase subunit C; Validated; Region: PRK07735 405535014545 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 405535014546 NADH dehydrogenase subunit B; Validated; Region: PRK06411 405535014547 NADH dehydrogenase subunit A; Validated; Region: PRK07756 405535014548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405535014549 PAS domain; Region: PAS_9; pfam13426 405535014550 putative active site [active] 405535014551 heme pocket [chemical binding]; other site 405535014552 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405535014553 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405535014554 metal binding site [ion binding]; metal-binding site 405535014555 active site 405535014556 I-site; other site 405535014557 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405535014558 Protein of unknown function (DUF975); Region: DUF975; cl10504 405535014559 Protein of unknown function (DUF975); Region: DUF975; cl10504 405535014560 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 405535014561 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 405535014562 gamma subunit interface [polypeptide binding]; other site 405535014563 epsilon subunit interface [polypeptide binding]; other site 405535014564 LBP interface [polypeptide binding]; other site 405535014565 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 405535014566 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 405535014567 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 405535014568 alpha subunit interaction interface [polypeptide binding]; other site 405535014569 Walker A motif; other site 405535014570 ATP binding site [chemical binding]; other site 405535014571 Walker B motif; other site 405535014572 inhibitor binding site; inhibition site 405535014573 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 405535014574 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 405535014575 core domain interface [polypeptide binding]; other site 405535014576 delta subunit interface [polypeptide binding]; other site 405535014577 epsilon subunit interface [polypeptide binding]; other site 405535014578 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 405535014579 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 405535014580 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 405535014581 beta subunit interaction interface [polypeptide binding]; other site 405535014582 Walker A motif; other site 405535014583 ATP binding site [chemical binding]; other site 405535014584 Walker B motif; other site 405535014585 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 405535014586 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 405535014587 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 405535014588 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 405535014589 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 405535014590 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 405535014591 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 405535014592 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 405535014593 ATP synthase I chain; Region: ATP_synt_I; pfam03899 405535014594 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 405535014595 Protein of unknown function (DUF4024); Region: DUF4024; pfam13216 405535014596 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405535014597 active site 405535014598 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 405535014599 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 405535014600 dimer interface [polypeptide binding]; other site 405535014601 active site 405535014602 glycine-pyridoxal phosphate binding site [chemical binding]; other site 405535014603 folate binding site [chemical binding]; other site 405535014604 hypothetical protein; Provisional; Region: PRK13690 405535014605 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 405535014606 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 405535014607 Low molecular weight phosphatase family; Region: LMWPc; cd00115 405535014608 active site 405535014609 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 405535014610 HPr interaction site; other site 405535014611 glycerol kinase (GK) interaction site [polypeptide binding]; other site 405535014612 active site 405535014613 phosphorylation site [posttranslational modification] 405535014614 Predicted membrane protein [Function unknown]; Region: COG2259 405535014615 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 405535014616 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 405535014617 Predicted membrane protein [Function unknown]; Region: COG1971 405535014618 Domain of unknown function DUF; Region: DUF204; pfam02659 405535014619 Domain of unknown function DUF; Region: DUF204; pfam02659 405535014620 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 405535014621 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 405535014622 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405535014623 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 405535014624 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 405535014625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535014626 S-adenosylmethionine binding site [chemical binding]; other site 405535014627 peptide chain release factor 1; Validated; Region: prfA; PRK00591 405535014628 This domain is found in peptide chain release factors; Region: PCRF; smart00937 405535014629 RF-1 domain; Region: RF-1; pfam00472 405535014630 thymidine kinase; Provisional; Region: PRK04296 405535014631 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 405535014632 transcription termination factor Rho; Provisional; Region: rho; PRK09376 405535014633 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 405535014634 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 405535014635 RNA binding site [nucleotide binding]; other site 405535014636 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 405535014637 multimer interface [polypeptide binding]; other site 405535014638 Walker A motif; other site 405535014639 ATP binding site [chemical binding]; other site 405535014640 Walker B motif; other site 405535014641 potential frameshift: common BLAST hit: gi|118480367|ref|YP_897518.1| fructose 1,6-bisphosphatase II 405535014642 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 405535014643 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 405535014644 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 405535014645 putative active site [active] 405535014646 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 405535014647 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 405535014648 hinge; other site 405535014649 active site 405535014650 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 405535014651 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 405535014652 intersubunit interface [polypeptide binding]; other site 405535014653 active site 405535014654 zinc binding site [ion binding]; other site 405535014655 Na+ binding site [ion binding]; other site 405535014656 Response regulator receiver domain; Region: Response_reg; pfam00072 405535014657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535014658 active site 405535014659 phosphorylation site [posttranslational modification] 405535014660 intermolecular recognition site; other site 405535014661 dimerization interface [polypeptide binding]; other site 405535014662 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 405535014663 CTP synthetase; Validated; Region: pyrG; PRK05380 405535014664 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 405535014665 Catalytic site [active] 405535014666 active site 405535014667 UTP binding site [chemical binding]; other site 405535014668 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 405535014669 active site 405535014670 putative oxyanion hole; other site 405535014671 catalytic triad [active] 405535014672 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 405535014673 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535014674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535014675 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405535014676 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 405535014677 FAD binding site [chemical binding]; other site 405535014678 homotetramer interface [polypeptide binding]; other site 405535014679 substrate binding pocket [chemical binding]; other site 405535014680 catalytic base [active] 405535014681 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405535014682 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 405535014683 FAD binding site [chemical binding]; other site 405535014684 homotetramer interface [polypeptide binding]; other site 405535014685 substrate binding pocket [chemical binding]; other site 405535014686 catalytic base [active] 405535014687 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 405535014688 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 405535014689 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 405535014690 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 405535014691 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 405535014692 dimer interface [polypeptide binding]; other site 405535014693 active site 405535014694 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 405535014695 4Fe-4S binding domain; Region: Fer4; cl02805 405535014696 Cysteine-rich domain; Region: CCG; pfam02754 405535014697 Cysteine-rich domain; Region: CCG; pfam02754 405535014698 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405535014699 PLD-like domain; Region: PLDc_2; pfam13091 405535014700 putative active site [active] 405535014701 catalytic site [active] 405535014702 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 405535014703 PLD-like domain; Region: PLDc_2; pfam13091 405535014704 putative active site [active] 405535014705 catalytic site [active] 405535014706 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 405535014707 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 405535014708 PAS domain S-box; Region: sensory_box; TIGR00229 405535014709 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405535014710 putative active site [active] 405535014711 heme pocket [chemical binding]; other site 405535014712 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405535014713 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405535014714 metal binding site [ion binding]; metal-binding site 405535014715 active site 405535014716 I-site; other site 405535014717 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405535014718 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 405535014719 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535014720 non-specific DNA binding site [nucleotide binding]; other site 405535014721 salt bridge; other site 405535014722 sequence-specific DNA binding site [nucleotide binding]; other site 405535014723 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405535014724 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405535014725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535014726 active site 405535014727 phosphorylation site [posttranslational modification] 405535014728 intermolecular recognition site; other site 405535014729 dimerization interface [polypeptide binding]; other site 405535014730 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405535014731 DNA binding residues [nucleotide binding] 405535014732 dimerization interface [polypeptide binding]; other site 405535014733 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405535014734 Q-cell neuroblast polarisation; Region: Dpy19; pfam10034 405535014735 Histidine kinase; Region: HisKA_3; pfam07730 405535014736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535014737 ATP binding site [chemical binding]; other site 405535014738 Mg2+ binding site [ion binding]; other site 405535014739 G-X-G motif; other site 405535014740 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 405535014741 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 405535014742 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405535014743 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405535014744 Walker A/P-loop; other site 405535014745 ATP binding site [chemical binding]; other site 405535014746 Q-loop/lid; other site 405535014747 ABC transporter signature motif; other site 405535014748 Walker B; other site 405535014749 D-loop; other site 405535014750 H-loop/switch region; other site 405535014751 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 405535014752 active site 405535014753 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 405535014754 Collagen binding domain; Region: Collagen_bind; pfam05737 405535014755 Collagen binding domain; Region: Collagen_bind; pfam05737 405535014756 Collagen binding domain; Region: Collagen_bind; pfam05737 405535014757 Collagen binding domain; Region: Collagen_bind; pfam05737 405535014758 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014759 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014760 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014761 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014762 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014763 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014764 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014765 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 405535014766 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014767 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014768 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014769 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014770 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 405535014771 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014772 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014773 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014774 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014775 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 405535014776 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014777 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014778 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014779 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014780 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 405535014781 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014782 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014783 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014784 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014785 Cna protein B-type domain; Region: Cna_B; pfam05738 405535014786 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 405535014787 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 405535014788 PA/protease or protease-like domain interface [polypeptide binding]; other site 405535014789 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 405535014790 Peptidase family M28; Region: Peptidase_M28; pfam04389 405535014791 metal binding site [ion binding]; metal-binding site 405535014792 RNA polymerase sigma factor; Provisional; Region: PRK12522 405535014793 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405535014794 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405535014795 DNA binding residues [nucleotide binding] 405535014796 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 405535014797 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 405535014798 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 405535014799 active site 405535014800 HIGH motif; other site 405535014801 KMSK motif region; other site 405535014802 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 405535014803 tRNA binding surface [nucleotide binding]; other site 405535014804 anticodon binding site; other site 405535014805 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 405535014806 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 405535014807 putative dimer interface [polypeptide binding]; other site 405535014808 catalytic triad [active] 405535014809 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405535014810 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 405535014811 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 405535014812 agmatinase; Region: agmatinase; TIGR01230 405535014813 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 405535014814 putative active site [active] 405535014815 Mn binding site [ion binding]; other site 405535014816 spermidine synthase; Provisional; Region: PRK00811 405535014817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535014818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535014819 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405535014820 putative substrate translocation pore; other site 405535014821 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405535014822 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 405535014823 DNA binding residues [nucleotide binding] 405535014824 putative dimer interface [polypeptide binding]; other site 405535014825 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 405535014826 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 405535014827 active site 405535014828 catalytic site [active] 405535014829 metal binding site [ion binding]; metal-binding site 405535014830 dimer interface [polypeptide binding]; other site 405535014831 Transglycosylase; Region: Transgly; pfam00912 405535014832 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 405535014833 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405535014834 YwhD family; Region: YwhD; pfam08741 405535014835 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 405535014836 Peptidase family M50; Region: Peptidase_M50; pfam02163 405535014837 active site 405535014838 putative substrate binding region [chemical binding]; other site 405535014839 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 405535014840 active site 1 [active] 405535014841 dimer interface [polypeptide binding]; other site 405535014842 hexamer interface [polypeptide binding]; other site 405535014843 active site 2 [active] 405535014844 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 405535014845 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405535014846 Zn2+ binding site [ion binding]; other site 405535014847 Mg2+ binding site [ion binding]; other site 405535014848 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405535014849 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 405535014850 intersubunit interface [polypeptide binding]; other site 405535014851 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405535014852 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405535014853 Walker A/P-loop; other site 405535014854 ATP binding site [chemical binding]; other site 405535014855 Q-loop/lid; other site 405535014856 ABC transporter signature motif; other site 405535014857 Walker B; other site 405535014858 D-loop; other site 405535014859 H-loop/switch region; other site 405535014860 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405535014861 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405535014862 ABC-ATPase subunit interface; other site 405535014863 dimer interface [polypeptide binding]; other site 405535014864 putative PBP binding regions; other site 405535014865 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405535014866 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405535014867 ABC-ATPase subunit interface; other site 405535014868 dimer interface [polypeptide binding]; other site 405535014869 putative PBP binding regions; other site 405535014870 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 405535014871 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 405535014872 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 405535014873 hypothetical protein; Provisional; Region: PRK12473 405535014874 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 405535014875 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 405535014876 putative heme peroxidase; Provisional; Region: PRK12276 405535014877 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 405535014878 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405535014879 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 405535014880 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 405535014881 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 405535014882 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 405535014883 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 405535014884 Ion channel; Region: Ion_trans_2; pfam07885 405535014885 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 405535014886 TrkA-N domain; Region: TrkA_N; pfam02254 405535014887 TrkA-C domain; Region: TrkA_C; pfam02080 405535014888 putative uracil/xanthine transporter; Provisional; Region: PRK11412 405535014889 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405535014890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535014891 motif II; other site 405535014892 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535014893 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 405535014894 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 405535014895 ligand binding site [chemical binding]; other site 405535014896 active site 405535014897 UGI interface [polypeptide binding]; other site 405535014898 catalytic site [active] 405535014899 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 405535014900 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 405535014901 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 405535014902 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405535014903 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 405535014904 Walker A/P-loop; other site 405535014905 ATP binding site [chemical binding]; other site 405535014906 Q-loop/lid; other site 405535014907 ABC transporter signature motif; other site 405535014908 Walker B; other site 405535014909 D-loop; other site 405535014910 H-loop/switch region; other site 405535014911 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 405535014912 active site 405535014913 catalytic triad [active] 405535014914 oxyanion hole [active] 405535014915 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405535014916 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405535014917 DNA binding site [nucleotide binding] 405535014918 domain linker motif; other site 405535014919 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 405535014920 putative dimerization interface [polypeptide binding]; other site 405535014921 putative ligand binding site [chemical binding]; other site 405535014922 Predicted membrane protein [Function unknown]; Region: COG2364 405535014923 homoserine dehydrogenase; Provisional; Region: PRK06349 405535014924 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 405535014925 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 405535014926 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 405535014927 homoserine O-succinyltransferase; Provisional; Region: PRK05368 405535014928 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 405535014929 proposed active site lysine [active] 405535014930 conserved cys residue [active] 405535014931 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 405535014932 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 405535014933 homodimer interface [polypeptide binding]; other site 405535014934 substrate-cofactor binding pocket; other site 405535014935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405535014936 catalytic residue [active] 405535014937 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 405535014938 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 405535014939 Cl- selectivity filter; other site 405535014940 Cl- binding residues [ion binding]; other site 405535014941 pore gating glutamate residue; other site 405535014942 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 405535014943 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535014944 active site 405535014945 motif I; other site 405535014946 motif II; other site 405535014947 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 405535014948 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405535014949 ligand binding site [chemical binding]; other site 405535014950 flexible hinge region; other site 405535014951 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 405535014952 azoreductase; Provisional; Region: PRK13556 405535014953 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405535014954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535014955 active site 405535014956 phosphorylation site [posttranslational modification] 405535014957 intermolecular recognition site; other site 405535014958 dimerization interface [polypeptide binding]; other site 405535014959 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405535014960 DNA binding residues [nucleotide binding] 405535014961 dimerization interface [polypeptide binding]; other site 405535014962 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 405535014963 GAF domain; Region: GAF; pfam01590 405535014964 GAF domain; Region: GAF_3; pfam13492 405535014965 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 405535014966 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405535014967 Histidine kinase; Region: HisKA_3; pfam07730 405535014968 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 405535014969 ATP binding site [chemical binding]; other site 405535014970 Mg2+ binding site [ion binding]; other site 405535014971 G-X-G motif; other site 405535014972 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 405535014973 dimer interface [polypeptide binding]; other site 405535014974 substrate binding site [chemical binding]; other site 405535014975 ATP binding site [chemical binding]; other site 405535014976 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 405535014977 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405535014978 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405535014979 metal binding site [ion binding]; metal-binding site 405535014980 active site 405535014981 I-site; other site 405535014982 Protein of unknown function (DUF466); Region: DUF466; pfam04328 405535014983 carbon starvation protein A; Provisional; Region: PRK15015 405535014984 Carbon starvation protein CstA; Region: CstA; pfam02554 405535014985 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 405535014986 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 405535014987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535014988 active site 405535014989 phosphorylation site [posttranslational modification] 405535014990 intermolecular recognition site; other site 405535014991 dimerization interface [polypeptide binding]; other site 405535014992 LytTr DNA-binding domain; Region: LytTR; pfam04397 405535014993 benzoate transport; Region: 2A0115; TIGR00895 405535014994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535014995 putative substrate translocation pore; other site 405535014996 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 405535014997 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 405535014998 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405535014999 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 405535015000 Predicted membrane protein [Function unknown]; Region: COG2860 405535015001 UPF0126 domain; Region: UPF0126; pfam03458 405535015002 UPF0126 domain; Region: UPF0126; pfam03458 405535015003 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 405535015004 heme-binding site [chemical binding]; other site 405535015005 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405535015006 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405535015007 dimer interface [polypeptide binding]; other site 405535015008 putative CheW interface [polypeptide binding]; other site 405535015009 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 405535015010 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 405535015011 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 405535015012 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 405535015013 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 405535015014 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 405535015015 active site 405535015016 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405535015017 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405535015018 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405535015019 ABC transporter; Region: ABC_tran_2; pfam12848 405535015020 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405535015021 conserved hypothetical integral membrane protein; Region: TIGR03766 405535015022 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 405535015023 Predicted membrane protein [Function unknown]; Region: COG2246 405535015024 GtrA-like protein; Region: GtrA; pfam04138 405535015025 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 405535015026 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 405535015027 Ligand binding site; other site 405535015028 Putative Catalytic site; other site 405535015029 DXD motif; other site 405535015030 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405535015031 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405535015032 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 405535015033 Protein export membrane protein; Region: SecD_SecF; cl14618 405535015034 methionine sulfoxide reductase A; Provisional; Region: PRK14054 405535015035 methionine sulfoxide reductase B; Provisional; Region: PRK00222 405535015036 SelR domain; Region: SelR; pfam01641 405535015037 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 405535015038 antiholin-like protein LrgB; Provisional; Region: PRK04288 405535015039 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 405535015040 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 405535015041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535015042 active site 405535015043 phosphorylation site [posttranslational modification] 405535015044 intermolecular recognition site; other site 405535015045 dimerization interface [polypeptide binding]; other site 405535015046 LytTr DNA-binding domain; Region: LytTR; pfam04397 405535015047 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 405535015048 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 405535015049 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 405535015050 Histidine kinase; Region: His_kinase; pfam06580 405535015051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535015052 ATP binding site [chemical binding]; other site 405535015053 Mg2+ binding site [ion binding]; other site 405535015054 G-X-G motif; other site 405535015055 PyrR binding site 405535015056 benzoate transport; Region: 2A0115; TIGR00895 405535015057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405535015058 putative substrate translocation pore; other site 405535015059 BCCT family transporter; Region: BCCT; pfam02028 405535015060 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 405535015061 active site 405535015062 dimer interface [polypeptide binding]; other site 405535015063 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 405535015064 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 405535015065 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 405535015066 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405535015067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405535015068 NAD(P) binding site [chemical binding]; other site 405535015069 active site 405535015070 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 405535015071 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 405535015072 UDP-glucose 4-epimerase; Region: PLN02240 405535015073 NAD binding site [chemical binding]; other site 405535015074 homodimer interface [polypeptide binding]; other site 405535015075 active site 405535015076 substrate binding site [chemical binding]; other site 405535015077 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 405535015078 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 405535015079 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 405535015080 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 405535015081 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 405535015082 ATP binding site [chemical binding]; other site 405535015083 Mg++ binding site [ion binding]; other site 405535015084 motif III; other site 405535015085 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405535015086 nucleotide binding region [chemical binding]; other site 405535015087 ATP-binding site [chemical binding]; other site 405535015088 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 405535015089 RNA binding site [nucleotide binding]; other site 405535015090 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 405535015091 Acyltransferase family; Region: Acyl_transf_3; pfam01757 405535015092 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 405535015093 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 405535015094 active site 405535015095 oligoendopeptidase F; Region: pepF; TIGR00181 405535015096 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 405535015097 active site 405535015098 Zn binding site [ion binding]; other site 405535015099 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 405535015100 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405535015101 FeS/SAM binding site; other site 405535015102 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 405535015103 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405535015104 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 405535015105 catalytic residues [active] 405535015106 catalytic nucleophile [active] 405535015107 Recombinase; Region: Recombinase; pfam07508 405535015108 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 405535015109 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 405535015110 GIY-YIG motif/motif A; other site 405535015111 active site 405535015112 catalytic site [active] 405535015113 metal binding site [ion binding]; metal-binding site 405535015114 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405535015115 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 405535015116 catalytic residues [active] 405535015117 catalytic nucleophile [active] 405535015118 Recombinase; Region: Recombinase; pfam07508 405535015119 Replication initiation factor; Region: Rep_trans; pfam02486 405535015120 Caspase domain; Region: Peptidase_C14; pfam00656 405535015121 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405535015122 Radical SAM superfamily; Region: Radical_SAM; pfam04055 405535015123 FeS/SAM binding site; other site 405535015124 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 405535015125 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 405535015126 TMP-binding site; other site 405535015127 ATP-binding site [chemical binding]; other site 405535015128 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 405535015129 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 405535015130 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 405535015131 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 405535015132 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 405535015133 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 405535015134 protein binding site [polypeptide binding]; other site 405535015135 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 405535015136 YycH protein; Region: YycI; pfam09648 405535015137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 405535015138 YycH protein; Region: YycH; pfam07435 405535015139 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 405535015140 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 405535015141 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535015142 dimerization interface [polypeptide binding]; other site 405535015143 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405535015144 putative active site [active] 405535015145 heme pocket [chemical binding]; other site 405535015146 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535015147 dimer interface [polypeptide binding]; other site 405535015148 phosphorylation site [posttranslational modification] 405535015149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535015150 ATP binding site [chemical binding]; other site 405535015151 Mg2+ binding site [ion binding]; other site 405535015152 G-X-G motif; other site 405535015153 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535015154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535015155 active site 405535015156 phosphorylation site [posttranslational modification] 405535015157 intermolecular recognition site; other site 405535015158 dimerization interface [polypeptide binding]; other site 405535015159 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535015160 DNA binding site [nucleotide binding] 405535015161 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 405535015162 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 405535015163 GDP-binding site [chemical binding]; other site 405535015164 ACT binding site; other site 405535015165 IMP binding site; other site 405535015166 replicative DNA helicase; Provisional; Region: PRK05748 405535015167 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 405535015168 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 405535015169 Walker A motif; other site 405535015170 ATP binding site [chemical binding]; other site 405535015171 Walker B motif; other site 405535015172 DNA binding loops [nucleotide binding] 405535015173 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 405535015174 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 405535015175 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 405535015176 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 405535015177 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 405535015178 DHH family; Region: DHH; pfam01368 405535015179 DHHA1 domain; Region: DHHA1; pfam02272 405535015180 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 405535015181 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 405535015182 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 405535015183 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 405535015184 dimer interface [polypeptide binding]; other site 405535015185 ssDNA binding site [nucleotide binding]; other site 405535015186 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405535015187 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 405535015188 GTP-binding protein YchF; Reviewed; Region: PRK09601 405535015189 YchF GTPase; Region: YchF; cd01900 405535015190 G1 box; other site 405535015191 GTP/Mg2+ binding site [chemical binding]; other site 405535015192 Switch I region; other site 405535015193 G2 box; other site 405535015194 Switch II region; other site 405535015195 G3 box; other site 405535015196 G4 box; other site 405535015197 G5 box; other site 405535015198 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 405535015199 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 405535015200 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 405535015201 Mechanosensitive ion channel; Region: MS_channel; pfam00924 405535015202 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 405535015203 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 405535015204 ParB-like nuclease domain; Region: ParB; smart00470 405535015205 KorB domain; Region: KorB; pfam08535 405535015206 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 405535015207 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 405535015208 P-loop; other site 405535015209 Magnesium ion binding site [ion binding]; other site 405535015210 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 405535015211 Magnesium ion binding site [ion binding]; other site 405535015212 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 405535015213 ParB-like nuclease domain; Region: ParBc; pfam02195 405535015214 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 405535015215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535015216 S-adenosylmethionine binding site [chemical binding]; other site 405535015217 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 405535015218 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 405535015219 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 405535015220 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 405535015221 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 405535015222 trmE is a tRNA modification GTPase; Region: trmE; cd04164 405535015223 G1 box; other site 405535015224 GTP/Mg2+ binding site [chemical binding]; other site 405535015225 Switch I region; other site 405535015226 G2 box; other site 405535015227 Switch II region; other site 405535015228 G3 box; other site 405535015229 G4 box; other site 405535015230 G5 box; other site 405535015231 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 405535015232 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 405535015233 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 405535015234 G-X-X-G motif; other site 405535015235 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 405535015236 RxxxH motif; other site 405535015237 OxaA-like protein precursor; Validated; Region: PRK02944 405535015238 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 405535015239 ribonuclease P; Reviewed; Region: rnpA; PRK00499 405535015240 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 405535015241 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 405535015242 DNA protecting protein DprA; Region: dprA; TIGR00732 405535015243 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 405535015244 Nuclease-related domain; Region: NERD; pfam08378 405535015245 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405535015246 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 405535015247 Probable transposase; Region: OrfB_IS605; pfam01385 405535015248 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405535015249 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405535015250 nucleotide binding region [chemical binding]; other site 405535015251 ATP-binding site [chemical binding]; other site 405535015252 Group II catalytic intron 405535015253 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 405535015254 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 405535015255 putative active site [active] 405535015256 putative NTP binding site [chemical binding]; other site 405535015257 putative nucleic acid binding site [nucleotide binding]; other site 405535015258 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 405535015259 active site 405535015260 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 405535015261 ATP binding site [chemical binding]; other site 405535015262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405535015263 S-adenosylmethionine binding site [chemical binding]; other site 405535015264 Group II catalytic intron 405535015265 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 405535015266 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 405535015267 putative active site [active] 405535015268 putative NTP binding site [chemical binding]; other site 405535015269 putative nucleic acid binding site [nucleotide binding]; other site 405535015270 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 405535015271 active site 405535015272 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 405535015273 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 405535015274 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535015275 non-specific DNA binding site [nucleotide binding]; other site 405535015276 sequence-specific DNA binding site [nucleotide binding]; other site 405535015277 salt bridge; other site 405535015278 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 405535015279 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 405535015280 active site 405535015281 catalytic residues [active] 405535015282 DNA binding site [nucleotide binding] 405535015283 Int/Topo IB signature motif; other site 405535015284 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 405535015285 Active Sites [active] 405535015286 HEPN domain; Region: HEPN; pfam05168 405535015287 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 405535015288 active site 405535015289 NTP binding site [chemical binding]; other site 405535015290 metal binding triad [ion binding]; metal-binding site 405535015291 antibiotic binding site [chemical binding]; other site 405535015292 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 405535015293 ATP binding site [chemical binding]; other site 405535015294 substrate interface [chemical binding]; other site 405535015295 PRTRC system protein A; Region: PRTRC_A; TIGR03735 405535015296 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 405535015297 Prokaryotic E2 family D; Region: Prok-E2_D; cl14019 405535015298 DNA polymerase III subunit beta; Validated; Region: PRK05643 405535015299 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 405535015300 putative DNA binding surface [nucleotide binding]; other site 405535015301 dimer interface [polypeptide binding]; other site 405535015302 beta-clamp/clamp loader binding surface; other site 405535015303 beta-clamp/translesion DNA polymerase binding surface; other site 405535015304 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 405535015305 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 405535015306 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 405535015307 active site 405535015308 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 405535015309 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 405535015310 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 405535015311 putative active site [active] 405535015312 putative NTP binding site [chemical binding]; other site 405535015313 putative nucleic acid binding site [nucleotide binding]; other site 405535015314 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 405535015315 Group II catalytic intron 405535015316 Domain of unknown function (DUF373); Region: DUF373; cl12079 405535015317 AAA-like domain; Region: AAA_10; pfam12846 405535015318 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 405535015319 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 405535015320 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 405535015321 Replication-relaxation; Region: Replic_Relax; pfam13814 405535015322 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 405535015323 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 405535015324 DNA binding residues [nucleotide binding] 405535015325 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 405535015326 S-layer homology domain; Region: SLH; pfam00395 405535015327 S-layer homology domain; Region: SLH; pfam00395 405535015328 S-layer homology domain; Region: SLH; pfam00395 405535015329 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 405535015330 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 405535015331 AAA domain; Region: AAA_31; pfam13614 405535015332 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 405535015333 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 405535015334 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 405535015335 Walker A motif; other site 405535015336 ATP binding site [chemical binding]; other site 405535015337 Walker B motif; other site 405535015338 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405535015339 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 405535015340 Probable transposase; Region: OrfB_IS605; pfam01385 405535015341 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405535015342 WxL domain surface cell wall-binding; Region: WxL; pfam13731 405535015343 Recombination protein U; Region: RecU; cl01314 405535015344 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 405535015345 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405535015346 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405535015347 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 405535015348 catalytic residues [active] 405535015349 catalytic nucleophile [active] 405535015350 Presynaptic Site I dimer interface [polypeptide binding]; other site 405535015351 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 405535015352 Synaptic Flat tetramer interface [polypeptide binding]; other site 405535015353 Synaptic Site I dimer interface [polypeptide binding]; other site 405535015354 DNA binding site [nucleotide binding] 405535015355 S-layer homology domain; Region: SLH; pfam00395 405535015356 S-layer homology domain; Region: SLH; pfam00395 405535015357 S-layer homology domain; Region: SLH; pfam00395 405535015358 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 405535015359 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 405535015360 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 405535015361 active site 405535015362 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 405535015363 RNAase interaction site [polypeptide binding]; other site 405535015364 oxo-acid-lyase/anthranilate synthase; Region: PLN02889 405535015365 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 405535015366 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 405535015367 active site 405535015368 metal binding site [ion binding]; metal-binding site 405535015369 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 405535015370 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 405535015371 PrgI family protein; Region: PrgI; pfam12666 405535015372 AAA-like domain; Region: AAA_10; pfam12846 405535015373 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 405535015374 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 405535015375 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405535015376 catalytic residue [active] 405535015377 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405535015378 Peptidase family M23; Region: Peptidase_M23; pfam01551 405535015379 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405535015380 NlpC/P60 family; Region: NLPC_P60; pfam00877 405535015381 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 405535015382 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 405535015383 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 405535015384 CAAX protease self-immunity; Region: Abi; pfam02517 405535015385 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 405535015386 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535015387 active site 405535015388 motif I; other site 405535015389 motif II; other site 405535015390 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 405535015391 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 405535015392 multiple promoter invertase; Provisional; Region: mpi; PRK13413 405535015393 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 405535015394 catalytic residues [active] 405535015395 catalytic nucleophile [active] 405535015396 Presynaptic Site I dimer interface [polypeptide binding]; other site 405535015397 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 405535015398 Synaptic Flat tetramer interface [polypeptide binding]; other site 405535015399 Synaptic Site I dimer interface [polypeptide binding]; other site 405535015400 DNA binding site [nucleotide binding] 405535015401 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405535015402 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405535015403 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405535015404 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405535015405 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405535015406 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535015407 non-specific DNA binding site [nucleotide binding]; other site 405535015408 salt bridge; other site 405535015409 sequence-specific DNA binding site [nucleotide binding]; other site 405535015410 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405535015411 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405535015412 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405535015413 Predicted membrane protein [Function unknown]; Region: COG2323 405535015414 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535015415 dimerization interface [polypeptide binding]; other site 405535015416 putative DNA binding site [nucleotide binding]; other site 405535015417 putative Zn2+ binding site [ion binding]; other site 405535015418 Sm and related proteins; Region: Sm_like; cl00259 405535015419 heptamer interface [polypeptide binding]; other site 405535015420 Sm1 motif; other site 405535015421 hexamer interface [polypeptide binding]; other site 405535015422 RNA binding site [nucleotide binding]; other site 405535015423 Sm2 motif; other site 405535015424 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 405535015425 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405535015426 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 405535015427 catalytic residues [active] 405535015428 catalytic nucleophile [active] 405535015429 Presynaptic Site I dimer interface [polypeptide binding]; other site 405535015430 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 405535015431 Synaptic Flat tetramer interface [polypeptide binding]; other site 405535015432 Synaptic Site I dimer interface [polypeptide binding]; other site 405535015433 DNA binding site [nucleotide binding] 405535015434 Predicted transcriptional regulators [Transcription]; Region: COG1733 405535015435 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 405535015436 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 405535015437 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 405535015438 substrate binding site [chemical binding]; other site 405535015439 catalytic Zn binding site [ion binding]; other site 405535015440 NAD binding site [chemical binding]; other site 405535015441 structural Zn binding site [ion binding]; other site 405535015442 dimer interface [polypeptide binding]; other site 405535015443 S-formylglutathione hydrolase; Region: PLN02442 405535015444 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 405535015445 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 405535015446 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 405535015447 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 405535015448 ATP-grasp domain; Region: ATP-grasp_4; cl17255 405535015449 Predicted membrane protein [Function unknown]; Region: COG2311 405535015450 Protein of unknown function (DUF418); Region: DUF418; cl12135 405535015451 Protein of unknown function (DUF418); Region: DUF418; pfam04235 405535015452 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405535015453 catalytic residues [active] 405535015454 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 405535015455 GIY-YIG motif/motif A; other site 405535015456 putative active site [active] 405535015457 putative metal binding site [ion binding]; other site 405535015458 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 405535015459 IHF dimer interface [polypeptide binding]; other site 405535015460 IHF - DNA interface [nucleotide binding]; other site 405535015461 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 405535015462 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 405535015463 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 405535015464 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 405535015465 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 405535015466 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 405535015467 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 405535015468 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 405535015469 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405535015470 Spore germination protein; Region: Spore_permease; cl17796 405535015471 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405535015472 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405535015473 multiple promoter invertase; Provisional; Region: mpi; PRK13413 405535015474 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 405535015475 catalytic residues [active] 405535015476 catalytic nucleophile [active] 405535015477 Presynaptic Site I dimer interface [polypeptide binding]; other site 405535015478 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 405535015479 Synaptic Flat tetramer interface [polypeptide binding]; other site 405535015480 Synaptic Site I dimer interface [polypeptide binding]; other site 405535015481 DNA binding site [nucleotide binding] 405535015482 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 405535015483 DNA-binding interface [nucleotide binding]; DNA binding site 405535015484 Clp protease; Region: CLP_protease; pfam00574 405535015485 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 405535015486 oligomer interface [polypeptide binding]; other site 405535015487 active site residues [active] 405535015488 Predicted membrane protein [Function unknown]; Region: COG2323 405535015489 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 405535015490 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 405535015491 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 405535015492 stage V sporulation protein AD; Provisional; Region: PRK12404 405535015493 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 405535015494 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 405535015495 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 405535015496 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405535015497 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405535015498 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405535015499 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 405535015500 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405535015501 active site 405535015502 metal binding site [ion binding]; metal-binding site 405535015503 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405535015504 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 405535015505 catalytic residues [active] 405535015506 catalytic nucleophile [active] 405535015507 Presynaptic Site I dimer interface [polypeptide binding]; other site 405535015508 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 405535015509 Synaptic Flat tetramer interface [polypeptide binding]; other site 405535015510 Synaptic Site I dimer interface [polypeptide binding]; other site 405535015511 DNA binding site [nucleotide binding] 405535015512 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 405535015513 DNA-binding interface [nucleotide binding]; DNA binding site 405535015514 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405535015515 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405535015516 multiple promoter invertase; Provisional; Region: mpi; PRK13413 405535015517 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 405535015518 catalytic residues [active] 405535015519 catalytic nucleophile [active] 405535015520 Presynaptic Site I dimer interface [polypeptide binding]; other site 405535015521 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 405535015522 Synaptic Flat tetramer interface [polypeptide binding]; other site 405535015523 Synaptic Site I dimer interface [polypeptide binding]; other site 405535015524 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 405535015525 DNA-binding interface [nucleotide binding]; DNA binding site 405535015526 Helix-turn-helix domain; Region: HTH_28; pfam13518 405535015527 Winged helix-turn helix; Region: HTH_29; pfam13551 405535015528 Homeodomain-like domain; Region: HTH_32; pfam13565 405535015529 Integrase core domain; Region: rve; pfam00665 405535015530 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 405535015531 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 405535015532 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 405535015533 multiple promoter invertase; Provisional; Region: mpi; PRK13413 405535015534 catalytic residues [active] 405535015535 catalytic nucleophile [active] 405535015536 Presynaptic Site I dimer interface [polypeptide binding]; other site 405535015537 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 405535015538 Synaptic Flat tetramer interface [polypeptide binding]; other site 405535015539 Synaptic Site I dimer interface [polypeptide binding]; other site 405535015540 DNA binding site [nucleotide binding] 405535015541 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 405535015542 DNA-binding interface [nucleotide binding]; DNA binding site 405535015543 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405535015544 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405535015545 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 405535015546 Spore germination protein; Region: Spore_permease; cl17796 405535015547 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405535015548 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405535015549 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405535015550 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405535015551 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405535015552 peptide binding site [polypeptide binding]; other site 405535015553 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405535015554 active site 405535015555 Int/Topo IB signature motif; other site 405535015556 DNA binding site [nucleotide binding] 405535015557 Helix-turn-helix domain; Region: HTH_17; pfam12728 405535015558 Double zinc ribbon; Region: DZR; pfam12773 405535015559 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 405535015560 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 405535015561 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 405535015562 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 405535015563 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535015564 dimerization interface [polypeptide binding]; other site 405535015565 putative DNA binding site [nucleotide binding]; other site 405535015566 putative Zn2+ binding site [ion binding]; other site 405535015567 HNH endonuclease; Region: HNH_5; pfam14279 405535015568 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 405535015569 stage II sporulation protein P; Region: spore_II_P; TIGR02867 405535015570 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 405535015571 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405535015572 dimerization interface [polypeptide binding]; other site 405535015573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405535015574 dimer interface [polypeptide binding]; other site 405535015575 phosphorylation site [posttranslational modification] 405535015576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405535015577 ATP binding site [chemical binding]; other site 405535015578 Mg2+ binding site [ion binding]; other site 405535015579 G-X-G motif; other site 405535015580 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405535015581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405535015582 active site 405535015583 phosphorylation site [posttranslational modification] 405535015584 intermolecular recognition site; other site 405535015585 dimerization interface [polypeptide binding]; other site 405535015586 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405535015587 DNA binding site [nucleotide binding] 405535015588 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 405535015589 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 405535015590 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 405535015591 Multicopper oxidase; Region: Cu-oxidase; pfam00394 405535015592 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 405535015593 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 405535015594 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405535015595 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405535015596 Walker A/P-loop; other site 405535015597 ATP binding site [chemical binding]; other site 405535015598 Q-loop/lid; other site 405535015599 ABC transporter signature motif; other site 405535015600 Walker B; other site 405535015601 D-loop; other site 405535015602 H-loop/switch region; other site 405535015603 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 405535015604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405535015605 dimer interface [polypeptide binding]; other site 405535015606 conserved gate region; other site 405535015607 putative PBP binding loops; other site 405535015608 ABC-ATPase subunit interface; other site 405535015609 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 405535015610 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405535015611 substrate binding pocket [chemical binding]; other site 405535015612 membrane-bound complex binding site; other site 405535015613 hinge residues; other site 405535015614 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 405535015615 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405535015616 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 405535015617 catalytic residues [active] 405535015618 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535015619 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535015620 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535015621 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 405535015622 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535015623 Bacterial SH3 domain; Region: SH3_3; pfam08239 405535015624 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405535015625 Peptidase family M23; Region: Peptidase_M23; pfam01551 405535015626 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 405535015627 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 405535015628 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 405535015629 Family description; Region: DsbD_2; pfam13386 405535015630 VPS10 domain; Region: VPS10; smart00602 405535015631 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 405535015632 dimerization interface [polypeptide binding]; other site 405535015633 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 405535015634 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 405535015635 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 405535015636 catalytic residues [active] 405535015637 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 405535015638 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 405535015639 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 405535015640 metal binding site [ion binding]; metal-binding site 405535015641 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 405535015642 putative homodimer interface [polypeptide binding]; other site 405535015643 putative homotetramer interface [polypeptide binding]; other site 405535015644 putative allosteric switch controlling residues; other site 405535015645 putative metal binding site [ion binding]; other site 405535015646 putative homodimer-homodimer interface [polypeptide binding]; other site 405535015647 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 405535015648 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405535015649 metal-binding site [ion binding] 405535015650 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 405535015651 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405535015652 metal-binding site [ion binding] 405535015653 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405535015654 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405535015655 motif II; other site 405535015656 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405535015657 metal-binding site [ion binding] 405535015658 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 405535015659 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 405535015660 AAA ATPase domain; Region: AAA_16; pfam13191 405535015661 AAA domain; Region: AAA_22; pfam13401 405535015662 Predicted permeases [General function prediction only]; Region: COG0701 405535015663 MarR family; Region: MarR_2; pfam12802 405535015664 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405535015665 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 405535015666 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 405535015667 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535015668 dimerization interface [polypeptide binding]; other site 405535015669 putative Zn2+ binding site [ion binding]; other site 405535015670 Phosphate transporter family; Region: PHO4; pfam01384 405535015671 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405535015672 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405535015673 non-specific DNA binding site [nucleotide binding]; other site 405535015674 salt bridge; other site 405535015675 sequence-specific DNA binding site [nucleotide binding]; other site 405535015676 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405535015677 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535015678 TPR motif; other site 405535015679 binding surface 405535015680 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405535015681 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405535015682 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405535015683 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 405535015684 B12 binding site [chemical binding]; other site 405535015685 Radical SAM superfamily; Region: Radical_SAM; pfam04055 405535015686 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405535015687 FeS/SAM binding site; other site 405535015688 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 405535015689 amphipathic channel; other site 405535015690 Asn-Pro-Ala signature motifs; other site 405535015691 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 405535015692 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 405535015693 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405535015694 Coenzyme A binding pocket [chemical binding]; other site 405535015695 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535015696 dimerization interface [polypeptide binding]; other site 405535015697 putative DNA binding site [nucleotide binding]; other site 405535015698 putative Zn2+ binding site [ion binding]; other site 405535015699 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 405535015700 arsenical-resistance protein; Region: acr3; TIGR00832 405535015701 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 405535015702 Low molecular weight phosphatase family; Region: LMWPc; cd00115 405535015703 active site 405535015704 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 405535015705 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 405535015706 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 405535015707 P loop; other site 405535015708 Nucleotide binding site [chemical binding]; other site 405535015709 DTAP/Switch II; other site 405535015710 Switch I; other site 405535015711 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 405535015712 P loop; other site 405535015713 Nucleotide binding site [chemical binding]; other site 405535015714 DTAP/Switch II; other site 405535015715 Switch I; other site 405535015716 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 405535015717 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 405535015718 active site 405535015719 catalytic residues [active] 405535015720 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 405535015721 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405535015722 active site 405535015723 DNA binding site [nucleotide binding] 405535015724 Int/Topo IB signature motif; other site 405535015725 TIR domain; Region: TIR_2; pfam13676 405535015726 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405535015727 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405535015728 TPR motif; other site 405535015729 binding surface 405535015730 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405535015731 dimerization interface [polypeptide binding]; other site 405535015732 putative DNA binding site [nucleotide binding]; other site 405535015733 putative Zn2+ binding site [ion binding]; other site 405535015734 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 405535015735 Staphylococcal nuclease homologues; Region: SNc; smart00318 405535015736 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 405535015737 Catalytic site; other site 405535015738 DNA topoisomerase III; Provisional; Region: PRK07726 405535015739 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 405535015740 active site 405535015741 putative interdomain interaction site [polypeptide binding]; other site 405535015742 putative metal-binding site [ion binding]; other site 405535015743 putative nucleotide binding site [chemical binding]; other site 405535015744 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 405535015745 domain I; other site 405535015746 DNA binding groove [nucleotide binding] 405535015747 phosphate binding site [ion binding]; other site 405535015748 domain II; other site 405535015749 domain III; other site 405535015750 nucleotide binding site [chemical binding]; other site 405535015751 catalytic site [active] 405535015752 domain IV; other site 405535015753 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 405535015754 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 405535015755 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 405535015756 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342